Web release v1.0.2
Curated evidence for oligonucleotide safety assessment
Explore toxicity and off-target observations for therapeutic oligonucleotides, linked to primary studies, exact source locations, evidence grades, and curation records.
Evidence release
Search the 737 curator-verified toxicity and off-target records.
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| Domain | Molecule | Modality | Evidence | Grade | Study |
|---|---|---|---|---|---|
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Primary studies
Release-linked bibliographic records with PMID, PMCID, DOI, and source URLs.
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| Year | Study | Journal | Identifiers |
|---|---|---|---|
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Downloads
Versioned release files with row counts, byte counts, and SHA-256 checksums.
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Curation and validation
Source-grounded curation with a complete audit trail for every release record.
Release construction
Human adjudication produced 737 release observations: 626 toxicity records and 111 off-target records from 660 primary studies.
Independent re-adjudication
- Stratified sample
- 126
- Machine-accepted subset
- 90
- False accepts
- 66
- False-accept rate
- 0.73
- Wilson 95% CI
- 0.63–0.81
Reproducible reuse
The release includes a data dictionary, source-level provenance, 737 audit rows, 344 fixed Grade A/B benchmark split rows, and checksums for each downloadable file.
Citation and versioned access
The archived snapshot and current web release are identified separately.
Recommended citation
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- Archived snapshot
- v1.0.1 · 10.5281/zenodo.20633779
- Current web release
- v1.0.2 · oligovigil.pages.dev
- Data license
- CC BY 4.0
- Code license
- MIT