{
  "version": "20260604_core_validation_v45",
  "claim_status": "not_claimable",
  "claim_boundary": "Cohen kappa is now claimed from the completed 100-row mixed inter-rater study (KAPPA-2; see kappa_claimed below). This separate 500-row independent second-review packet underwrites the release-row false-accept / false-reject ERROR-RATE estimates, which remain pending until reviewer2_decision is filled and adjudicated; the live agreement/kappa fields in this endpoint are computed from that 500-row packet and are null until it is filled.",
  "kappa_claimed": {
    "status": "claimed",
    "study": "100-row mixed inter-rater study (KAPPA-2), second curator HY (blinded, no manuscript exposure)",
    "cohen_kappa_binary_drop_abstain": 0.42,
    "cohen_kappa_binary_drop_abstain_detail": "moderate (Landis-Koch); drop-abstain convention, n=92 non-abstain rows",
    "cohen_kappa_binary_collapse_abstain": 0.34,
    "cohen_kappa_binary_collapse_abstain_detail": "fair (Landis-Koch); safety-conservative collapse-abstain convention, n=100",
    "cohen_kappa_3class": 0.37,
    "cohen_kappa_grade": 0.39,
    "raw_agreement": 0.66,
    "raw_agreement_detail": "66% (66/100), 3-class accept/reject/abstain",
    "second_curator": "HY, blinded, no manuscript exposure; systematically stricter (92% reject-confirm, 40% accept-confirm) — conservative direction for a safety database",
    "third_adjudicator": "A10 third-adjudicator consensus pass is in progress (not yet returned); will further refine kappa once adjudicated."
  },
  "sample": {
    "sample_rows": 500,
    "reviewed_rows": 0,
    "comparable_rows": 0,
    "release_accept_rows": 250,
    "candidate_reject_control_rows": 250,
    "completion_pct": 0.0
  },
  "metrics": {
    "raw_agreement": null,
    "cohen_kappa": null,
    "false_accept_rate_release_rows": null,
    "false_reject_rate_reject_controls": null,
    "source_location_disagreement_rows": 0
  },
  "sampling_breakdown": [
    {
      "item_type": "candidate_reject_control",
      "rows": 250
    },
    {
      "item_type": "release_accept",
      "rows": 250
    }
  ],
  "top_strata": [
    {
      "stratum": "candidate_reject_control/offtarget/C/siRNA",
      "rows": 93
    },
    {
      "stratum": "release_accept/toxicity_endpoint/C/no",
      "rows": 70
    },
    {
      "stratum": "release_accept/toxicity_endpoint/A/yes",
      "rows": 64
    },
    {
      "stratum": "candidate_reject_control/offtarget/B/siRNA",
      "rows": 48
    },
    {
      "stratum": "release_accept/toxicity_endpoint/B/no",
      "rows": 40
    },
    {
      "stratum": "candidate_reject_control/offtarget/C/ASO",
      "rows": 37
    },
    {
      "stratum": "release_accept/toxicity_endpoint/B/yes",
      "rows": 29
    },
    {
      "stratum": "candidate_reject_control/offtarget/B/ASO",
      "rows": 25
    },
    {
      "stratum": "release_accept/offtarget_evidence/B/yes",
      "rows": 17
    },
    {
      "stratum": "release_accept/offtarget_evidence/A/yes",
      "rows": 11
    },
    {
      "stratum": "candidate_reject_control/toxicity/B/ASO/siRNA",
      "rows": 11
    },
    {
      "stratum": "candidate_reject_control/toxicity/B/ASO",
      "rows": 8
    }
  ],
  "review_fields": [
    {
      "field": "reviewer2_decision",
      "allowed_values": "accept | reject",
      "use": "Independent second reviewer repeats the release/reject decision from source evidence."
    },
    {
      "field": "reviewer2_evidence_grade",
      "allowed_values": "A | B | C | reject",
      "use": "Grade disagreement is counted separately from accept/reject disagreement."
    },
    {
      "field": "reviewer2_source_location_verified",
      "allowed_values": "yes | no",
      "use": "Checks whether the cited source location actually supports the evidence claim."
    },
    {
      "field": "reviewer2_error_type",
      "allowed_values": "scope_error | source_location_error | grade_error | duplicate | extraction_error | none",
      "use": "Feeds the manuscript error-rate estimate after adjudication."
    }
  ],
  "downloads": {
    "independent_validation_template": "/api/download/independent_curation_validation_template.csv",
    "independent_validation_manifest": "/api/manifest/independent_curation_validation_template_v1.csv",
    "curation_audit": "/api/download/curation_audit.csv"
  }
}