validation_sample_id,item_type,stratum,evidence_domain,entity_table,entity_id,evidence_grade,benchmark_eligible,molecule_id,canonical_name,modality,target_gene_symbol,evidence_label,source_document_id,pmid,pmcid,doi,source_title,source_url,source_location,matched_terms,original_curator_decision,original_validation_status,original_audit_note,reviewer2_decision,reviewer2_evidence_grade,reviewer2_source_location_verified,reviewer2_error_type,reviewer2_note,adjudication_decision,adjudicator_note,do_not_change_release_until_adjudicated
iv-release-0001,release_accept,release_accept/offtarget_evidence/A/no,offtarget,offtarget_evidence,40,A,no,218,SPC2996; PC3; CaCo2,ASO,,off-target evidence,2845,19854938,PMC2800216,10.1093/nar/gkp841,"Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.",https://pubmed.ncbi.nlm.nih.gov/19854938/,RESULTS AND DISCUSSION > Gene silencing by gymnotic delivery is a general phenomenon; paragraph 15,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide offtarget evidence for off-target evidence; location=RESULTS AND DISCUSSION > Gene silencing by gymnotic delivery is a general phenomenon; paragraph 15.,,,,,,,,TRUE
iv-release-0002,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,7,A,yes,10,ALN-HBV/ALN-HBV02 GalNAc-siRNA panel from PMID 35736224,siRNA,HBV,seed-mediated off-target effect,1411,35736224,PMC9262600,10.1093/nar/gkac539,From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.,https://pubmed.ncbi.nlm.nih.gov/35736224/,RESULTS > Application of ESC+ design to improve the specificity and safety of ALN-HBV; paragraph 46,,accept,curator_verified,"We found that the ESC+ version of ALN-HBV, named ALN-HBV02, with a single GNA substitution at position 6 of the guide strand, and without any further changes in sequence or chemistry, minimizes off-target dysregulation without compromising on-target activity.",,,,,,,,TRUE
iv-release-0003,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,115,A,yes,435,siRNAs,siRNA,,off-target evidence,1788,41373822,PMC12692593,10.3390/ijms262311675,Respiratory Delivery of Highly Conserved Antiviral siRNAs Suppress SARS-CoV-2 Infection.,https://pubmed.ncbi.nlm.nih.gov/41373822/,2. Results > 2.4. Gene Silencing Effect of Chemically Modified siRNAs; paragraph 14,,accept,machine_precurated_v1,Verified full text evidence at 2. Results > 2.4. Gene Silencing Effect of Chemically Modified siRNAs; paragraph 14: primary offtarget support for off-target evidence in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0004,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,63,A,yes,435,siRNAs,siRNA,,seed-mediated off-target effect,12558,33664996,PMC7900643,10.1016/j.omtn.2021.01.018,AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity.,https://pubmed.ncbi.nlm.nih.gov/33664996/,Results > Transcriptome-wide analyses of mi/siRNAs targeting E6/E7; paragraph 17,,accept,machine_precurated_v1,Verified full text evidence at Results > Transcriptome-wide analyses of mi/siRNAs targeting E6/E7; paragraph 17: primary offtarget support for seed-mediated off-target effect in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0005,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,67,A,yes,438,LNA ASO,ASO,,hybridization/mismatch off-target effect,2062,26553810,PMC4797265,10.1093/nar/gkv1210,Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.,https://pubmed.ncbi.nlm.nih.gov/26553810/,RESULTS > Hepatotoxicity of LNA ASOs is RNase H1 dependent; paragraph 35,,accept,machine_precurated_v1,Verified full text evidence at RESULTS > Hepatotoxicity of LNA ASOs is RNase H1 dependent; paragraph 35: primary offtarget support for hybridization/mismatch off-target effect in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0006,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,1,A,yes,4,SNA-modified GalNAc-siRNA panel from PMID 41994868,siRNA,TTR,seed-mediated off-target effect,1031,41994868,PMC13096799,10.1093/nar/gkag345,Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.,https://pubmed.ncbi.nlm.nih.gov/41994868/,Results > Analysis of miRNA-like off-target activity in a luciferase reporter assay; paragraph 3,,accept,curator_verified,"The greatest impact of SNA modification was observed when included at position g7 in si-50, with a relative off-target IC50 increase of ~260-fold over the parent si-47.",,,,,,,,TRUE
iv-release-0007,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,4,A,yes,7,APP-AON/ATXN3-AON/HTT-AON panel from PMID 41066632,ASO,,hybridization/mismatch off-target effect,1442,41066632,PMC12581821,10.1093/hmg/ddaf153,Determining off-target effects of splice-switching antisense oligonucleotides using short read RNAseq in neuronally differentiated human induced pluripotent stem cells.,https://pubmed.ncbi.nlm.nih.gov/41066632/,Results > Hybridization-dependent off-target splicing events do not play a major role after transfection; paragraph 19,,accept,curator_verified,"In this study, we used three different splice-switching AONs targeting three different human transcripts to study their transcriptome-wide, hybridization-dependent off-target effects with short read RNAseq.",,,,,,,,TRUE
iv-release-0008,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,66,A,yes,992,"Sequence 1 (recovered B2 from PMID:28918038, curator:CM)",ASO,,transcriptome-level off-target effect,2064,28918038,PMC5537172,10.1016/j.omtn.2017.07.003,Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.,https://pubmed.ncbi.nlm.nih.gov/28918038/,Results > High Confirmation Rate of In Silico Predicted OTEs in Mouse Liver; paragraph 14,,accept,machine_precurated_v1,Verified full text evidence at Results > High Confirmation Rate of In Silico Predicted OTEs in Mouse Liver; paragraph 14: primary offtarget support for transcriptome-level off-target effect in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0009,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,6,A,yes,9,DM1 ASO panel from PMID 37200862,ASO,DMPK,transcriptome-level off-target effect,1481,37200862,PMC10185704,10.1016/j.omtn.2023.04.010,Block or degrade? Balancing on- and off-target effects of antisense strategies against transcripts with expanded triplet repeats in DM1.,https://pubmed.ncbi.nlm.nih.gov/37200862/,Results > RNA-seq reveals activation of the interferon response by all ASOs and additional off-target effects on gene expression by the repeat gapmer; paragraph 3,,accept,curator_verified,"by performing RNA sequencing (RNA-seq) for cells after ASO treatment, we assessed both on- and off-target effects of the ASOs on a transcriptome-wide level.",,,,,,,,TRUE
iv-release-0010,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,222,A,yes,1004,"FM10 (recovered B2 from PMID:27378237, curator:CM)",PMO,,transcriptome-level off-target effect,15206,27378237,PMC5023379,10.1038/mt.2016.111,Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics.,https://pubmed.ncbi.nlm.nih.gov/27378237/,Results; paragraph 9,,accept,machine_precurated_v1,Verified full text evidence at Results; paragraph 9: primary offtarget support for transcriptome-level off-target effect in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0011,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,116,A,yes,996,unspecified siRNA (PMID:41341748),siRNA,,seed-mediated off-target effect,1789,41341748,PMC12670904,10.1016/j.omtn.2025.102768,A novel bispecific siRNA concept: Efficient dual knockdown of YAP1 and WWTR1 with a single guide strand.,https://pubmed.ncbi.nlm.nih.gov/41341748/,Results > Characterization of off-target activities of bsYW-61; paragraph 14,,accept,machine_precurated_v1,Verified full text evidence at Results > Characterization of off-target activities of bsYW-61; paragraph 14: primary offtarget support for seed-mediated off-target effect in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0012,release_accept,release_accept/offtarget_evidence/A/yes,offtarget,offtarget_evidence,78,A,yes,986,"unspecified ASO (v1 extraction artefact, pending source re-verification)",ASO,,transcriptome-level off-target effect,1035,41918821,PMC13034028,10.1093/narmme/ugag016,Integrating transcriptomics and proteomics to assess antisense oligonucleotide safety and efficacy: a time-resolved approach.,https://pubmed.ncbi.nlm.nih.gov/41918821/,Results > ASO off-target RNA reduction correlates well with off-target protein reduction in HepG2 cells; paragraph 48,,accept,machine_precurated_v1,Verified full text evidence at Results > ASO off-target RNA reduction correlates well with off-target protein reduction in HepG2 cells; paragraph 48: primary offtarget support for transcriptome-level off-target effect in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0013,release_accept,release_accept/offtarget_evidence/B/no,offtarget,offtarget_evidence,73,B,no,441,designated ASO,ASO,,hybridization/mismatch off-target effect,1453,39192097,,10.1007/s10120-024-01548-9,Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer.,https://pubmed.ncbi.nlm.nih.gov/39192097/,PubMed abstract,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary offtarget support for hybridization/mismatch off-target effect in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0014,release_accept,release_accept/offtarget_evidence/B/no,offtarget,offtarget_evidence,229,B,no,1065,"MC3 LNP-siRNA (recovered B2 from PMID:41708903, curator:CM)",siRNA,,off-target evidence,1209,41708903,,10.1007/s13346-026-02076-y,Comparative analysis of clinically approved lipid nanoparticles for intranasal siRNA delivery against SARS-CoV-2.,https://pubmed.ncbi.nlm.nih.gov/41708903/,PubMed abstract,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary offtarget support for off-target evidence in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0015,release_accept,release_accept/offtarget_evidence/B/no,offtarget,offtarget_evidence,33,B,no,212,ADO2,siRNA,,seed-mediated off-target effect,3759,39934917,PMC11816505,10.1186/s13287-025-04151-6,Development and evaluation of siRNA-mediated gene silencing strategies for ADO2 therapy utilizing iPSCs model and DMPC-SPIONs delivery system.,https://pubmed.ncbi.nlm.nih.gov/39934917/,Discussion; paragraph 15,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide offtarget evidence for seed-mediated off-target effect; location=Discussion; paragraph 15.,,,,,,,,TRUE
iv-release-0016,release_accept,release_accept/offtarget_evidence/B/no,offtarget,offtarget_evidence,56,B,no,370,PDIA3; oblimersen,siRNA,,off-target evidence,2270,20544786,,10.1002/cmdc.201000156,Off-target effects related to the phosphorothioate modification of nucleic acids.,https://pubmed.ncbi.nlm.nih.gov/20544786/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide offtarget evidence for off-target evidence; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0017,release_accept,release_accept/offtarget_evidence/B/no,offtarget,offtarget_evidence,47,B,no,186,unspecified antisense oligonucleotide,ASO,,transcriptome-level off-target effect,2216,33314011,,10.1007/s40291-020-00504-4,Using RNA-seq to Assess Off-Target Effects of Antisense Oligonucleotides in Human Cell Lines.,https://pubmed.ncbi.nlm.nih.gov/33314011/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide offtarget evidence for transcriptome-level off-target effect; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0018,release_accept,release_accept/offtarget_evidence/B/no,offtarget,offtarget_evidence,49,B,no,256,siF12; siF12-A; siF12-AC9,siRNA,,hybridization/mismatch off-target effect,12115,31063435,,10.1089/nat.2018.0767,"Use of ""C9/11 Mismatch"" Control siRNA Reveals Sequence-Related Off-Target Effect on Coagulation of an siRNA Targeting Mouse Coagulation Factor XII.",https://pubmed.ncbi.nlm.nih.gov/31063435/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide offtarget evidence for hybridization/mismatch off-target effect; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0019,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,386,B,yes,829,TNFR1,siRNA,,seed-mediated off-target effect,21536,18096615,PMC2275081,10.1093/nar/gkm630,Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect.,https://pubmed.ncbi.nlm.nih.gov/18096615/,RESULTS > 736 SENSE STRAND ACTIVITY IS INHIBITED BY CHEMICAL AND SEQUENCE MODIFICATION; paragraph 30,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as seed-mediated off-target effect for TNFR1.,,,,,,,,TRUE
iv-release-0020,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,473,B,yes,902,UU-3,siRNA,,off-target evidence,3544,40861898,PMC12375242,10.1016/j.omtn.2025.102667,Development of conditional-siRNA programmable riboswitch for targeting adverse cardiac remodeling.,https://pubmed.ncbi.nlm.nih.gov/40861898/,Results > Synthesis of a Cond-siRNA construct based on RNA sensor Nppa and target gene calcineurin; paragraph 11,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as off-target evidence for UU-3.,,,,,,,,TRUE
iv-release-0021,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,370,B,yes,815,60 siRNA,siRNA,,seed-mediated off-target effect,16582,24875475,PMC4081087,10.1093/nar/gku480,siPools: highly complex but accurately defined siRNA pools eliminate off-target effects.,https://pubmed.ncbi.nlm.nih.gov/24875475/,RESULTS > siPools affect global transcript levels less than single siRNAs; Figure 4. caption,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as seed-mediated off-target effect for 60 siRNA.,,,,,,,,TRUE
iv-release-0022,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,331,B,yes,778,F7-1 siRNA,siRNA,,seed-mediated off-target effect,15845,22258146,PMC3342946,10.4161/rna.9.1.18121,Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7.,https://pubmed.ncbi.nlm.nih.gov/22258146/,Results > Enrichment analysis of seed region matches in F7-1 off-target genes; paragraph 13,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as seed-mediated off-target effect for F7-1 siRNA.,,,,,,,,TRUE
iv-release-0023,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,506,B,yes,932,siIGF1R-1,ASO,,hybridization/mismatch off-target effect,14112,37251692,PMC10220282,10.1016/j.omtn.2023.04.028,Modified ASO conjugates encapsulated with cytidinyl/cationic lipids exhibit more potent and longer-lasting anti-HCC effects.,https://pubmed.ncbi.nlm.nih.gov/37251692/,Results > Transcriptomics and proteomics analysis of modified CT102s; paragraph 23,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as hybridization/mismatch off-target effect for siIGF1R-1.,,,,,,,,TRUE
iv-release-0024,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,456,B,yes,886,modified siRNA,siRNA,,hybridization/mismatch off-target effect,3301,41552385,PMC12804371,10.1016/j.omtn.2025.102802,An acyclic nucleic acid-modified siRNA targeting CAG expansions for polyglutamine disease treatment.,https://pubmed.ncbi.nlm.nih.gov/41552385/,Results > Screening of SNA-modified siRNAs targeting CAG repeats; paragraph 8,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as hybridization/mismatch off-target effect for modified siRNA.,,,,,,,,TRUE
iv-release-0025,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,464,B,yes,894,ACTB ASO,ASO,,transcriptome-level off-target effect,1824,40672232,PMC12265680,10.1101/2025.07.11.664364,Targeted RNA editing by direct delivery of an adenosine deaminase-antisense oligo conjugate.,https://pubmed.ncbi.nlm.nih.gov/40672232/,RESULTS > RNP delivery reduces transcriptome-wide off-target editing; paragraph 22,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as transcriptome-level off-target effect for ACTB ASO.,,,,,,,,TRUE
iv-release-0026,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,392,B,yes,438,LNA ASO,ASO,,hybridization/mismatch off-target effect,2062,26553810,PMC4797265,10.1093/nar/gkv1210,Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.,https://pubmed.ncbi.nlm.nih.gov/26553810/,RESULTS > Hepatotoxicity of LNA ASOs is RNase H1 dependent; paragraph 35,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as hybridization/mismatch off-target effect for LNA ASO.,,,,,,,,TRUE
iv-release-0027,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,436,B,yes,869,ASO-001933,ASO,,seed-mediated off-target effect,1615,36090761,PMC9424863,10.1016/j.omtn.2022.07.027,Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.,https://pubmed.ncbi.nlm.nih.gov/36090761/,Results > Initial tiling screen identified a parental ASO targeting the 3′ UTR of MAPT with high cross-species reactivity; paragraph 6,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as seed-mediated off-target effect for ASO-001933.,,,,,,,,TRUE
iv-release-0028,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,340,B,yes,785,GR18-3 ASO,ASO,,hybridization/mismatch off-target effect,28684,34994962,PMC8766371,10.1007/s40291-021-00573-z,Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension.,https://pubmed.ncbi.nlm.nih.gov/34994962/,Results > Comparative Analysis of Off-Target Effects; paragraph 23,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as hybridization/mismatch off-target effect for GR18-3 ASO.,,,,,,,,TRUE
iv-release-0029,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,414,B,yes,850,CD-1,ASO,,off-target evidence,2063,24550163,PMC4005641,10.1093/nar/gku142,Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides.,https://pubmed.ncbi.nlm.nih.gov/24550163/,RESULTS > Evaluation of hepatotoxicity in mice; paragraph 14,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as off-target evidence for CD-1.,,,,,,,,TRUE
iv-release-0030,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,383,B,yes,826,siEGFP1,siRNA,,seed-mediated off-target effect,15558,20453030,PMC2943616,10.1093/nar/gkq341,A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.,https://pubmed.ncbi.nlm.nih.gov/20453030/,RESULTS > siRNA titrations reveal reduced off-targeting by siRNA UNA modification; paragraph 13,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as seed-mediated off-target effect for siEGFP1.,,,,,,,,TRUE
iv-release-0031,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,534,B,yes,956,89E-06,ASO,,hybridization/mismatch off-target effect,2064,28918038,PMC5537172,10.1016/j.omtn.2017.07.003,Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.,https://pubmed.ncbi.nlm.nih.gov/28918038/,Results > High Confirmation Rate of In Silico Predicted OTEs in Mouse Liver; paragraph 14,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as hybridization/mismatch off-target effect for 89E-06.,,,,,,,,TRUE
iv-release-0032,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,334,B,yes,781,modified duplex,siRNA,,seed-mediated off-target effect,1031,41994868,PMC13096799,10.1093/nar/gkag345,Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.,https://pubmed.ncbi.nlm.nih.gov/41994868/,Results > In vitro gene silencing of modified siRNA containing SNA modifications; paragraph 28,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as seed-mediated off-target effect for modified duplex.,,,,,,,,TRUE
iv-release-0033,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,13,B,yes,100,ASO candidate from PMID 36229039,ASO,,hybridization/mismatch off-target effect,2306,36229039,PMC9825163,10.1093/nar/gkac838,INRI-seq enables global cell-free analysis of translation initiation and off-target effects of antisense inhibitors.,https://pubmed.ncbi.nlm.nih.gov/36229039/,RESULTS > INRI-seq identifies direct PNA off-targets; paragraph 50,,accept,machine_precurated_v1,PMC full text checked; verified source supports hybridization/mismatch off-target effect.,,,,,,,,TRUE
iv-release-0034,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,384,B,yes,827,Ago2; Ago1,siRNA,,seed-mediated off-target effect,15470,19767612,PMC2777430,10.1093/nar/gkp735,Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.,https://pubmed.ncbi.nlm.nih.gov/19767612/,RESULTS > Ago2 is not required for PIK3CB off-target and some on-target siRNA activity; paragraph 15,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as seed-mediated off-target effect for Ago2; Ago1.,,,,,,,,TRUE
iv-release-0035,release_accept,release_accept/offtarget_evidence/B/yes,offtarget,offtarget_evidence,339,B,yes,784,BTK siRNA,siRNA,,seed-mediated off-target effect,20894,16091630,PMC1184219,10.1093/nar/gki762,siRNA-mediated off-target gene silencing triggered by a 7 nt complementation.,https://pubmed.ncbi.nlm.nih.gov/16091630/,RESULTS > A 7 nt complementation between the original GRK4(O)/BTK(O) siRNAs and the hif-1α mRNA triggers the degradation of hif-1α mRNA; paragraph 15,,accept,machine_precurated_v1,Human verified PMC full-text anchor; accepted as seed-mediated off-target effect for BTK siRNA.,,,,,,,,TRUE
iv-release-0036,release_accept,release_accept/offtarget_evidence/C/no,offtarget,offtarget_evidence,281,C,no,733,bulge-siRNA,siRNA,,seed-mediated off-target effect,15373,21673662,PMC3182346,10.1038/mt.2011.109,Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing.,https://pubmed.ncbi.nlm.nih.gov/21673662/,PubMed abstract,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary off-target support for seed-mediated off-target effect in a molecule-specific oligonucleotide context.,,,,,,,,TRUE
iv-release-0037,release_accept,release_accept/offtarget_evidence/C/no,offtarget,offtarget_evidence,21,C,no,136,siRNA candidate from PMID 39813044,siRNA,,sequence-specificity/off-target evidence,12147,39813044,PMC12522049manuscript-id: NIHMS2116935,10.1021/acschembio.4c00824,Amide Internucleoside Linkages Suppress the MicroRNA-like Off-Target Activity of Short Interfering RNA.,https://pubmed.ncbi.nlm.nih.gov/39813044/,Results and Discussion; paragraph 13,,accept,machine_precurated_v1,PMC full text checked; verified source supports sequence-specificity/off-target evidence.,,,,,,,,TRUE
iv-release-0038,release_accept,release_accept/offtarget_evidence/C/no,offtarget,offtarget_evidence,20,C,no,135,siRNA candidate from PMID 41646886,siRNA,,seed-mediated off-target effect,1154,41646886,PMC12870468,10.1016/j.omtn.2026.102835,2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs.,https://pubmed.ncbi.nlm.nih.gov/41646886/,Discussion; paragraph 27,,accept,machine_precurated_v1,PMC full text checked; verified source supports seed-mediated off-target effect.,,,,,,,,TRUE
iv-release-0039,release_accept,release_accept/offtarget_evidence/C/no,offtarget,offtarget_evidence,22,C,no,137,siRNA candidate from PMID 39231537,siRNA,,seed-mediated off-target effect,12077,39231537,PMC11472056,10.1093/nar/gkae741,Synthesis of 2'-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs.,https://pubmed.ncbi.nlm.nih.gov/39231537/,Results and discussion > Genome-wide evaluation of off-target activities; paragraph 77,,accept,machine_precurated_v1,PMC full text checked; verified source supports seed-mediated off-target effect.,,,,,,,,TRUE
iv-release-0040,release_accept,release_accept/offtarget_evidence/C/no,offtarget,offtarget_evidence,26,C,no,141,ASO candidate from PMID 34388351,ASO,,hybridization/mismatch off-target effect,2113,34388351,PMC8713556,10.1089/nat.2020.0921,Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides.,https://pubmed.ncbi.nlm.nih.gov/34388351/,Introduction; paragraph 4,,accept,machine_precurated_v1,PMC full text checked; verified source supports hybridization/mismatch off-target effect.,,,,,,,,TRUE
iv-release-0041,release_accept,release_accept/toxicity_endpoint/A/no,toxicity,toxicity_endpoint,203,A,no,185,unspecified siRNA,siRNA,,hepatic: hepatotoxicity,1551,39861693,PMC11769357,10.3390/pharmaceutics17010045,Innovative Lipid Nanoparticles Co-Delivering Hydroxychloroquine and siRNA for Enhanced Rheumatoid Arthritis Therapy.,https://pubmed.ncbi.nlm.nih.gov/39861693/,3. Results and Discussion > 3.2. Cytotoxicity of LNP-siN.C./siTNF-α and LNP-siN.C./siTNF-α-HCQ; paragraph 26,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=3. Results and Discussion > 3.2. Cytotoxicity of LNP-siN.C./siTNF-α and LNP-siN.C./siTNF-α-HCQ; paragraph 26.,,,,,,,,TRUE
iv-release-0042,release_accept,release_accept/toxicity_endpoint/A/no,toxicity,toxicity_endpoint,446,A,no,402,CDs-pDEAEMA/BIRC5 siRNA,siRNA,BIRC5,general safety: cytocompatibility/erythrocompatibility,3695,40347142,PMC12152932,10.1021/acs.biomac.5c00267,Poly(2-(diethylamino)ethyl methacrylate)-Functionalized Carbon Nanodots as Theranostic Platforms for siRNA Delivery and Survivin Silencing in Triple-Negative Breast Cancer.,https://pubmed.ncbi.nlm.nih.gov/40347142/,Results and Discussion > Cell Compatibility; paragraph 50,,accept,machine_precurated_v1,accepted: verified primary cell-compatibility Results for siRNA carbon-nanodot complexes; lower ratios were cytocompatible and erythrocompatibility was also assessed.,,,,,,,,TRUE
iv-release-0043,release_accept,release_accept/toxicity_endpoint/A/no,toxicity,toxicity_endpoint,237,A,no,186,unspecified antisense oligonucleotide,ASO,,hepatic: hepatotoxicity,2768,32260534,PMC7226018,10.3390/biom10040553,Chitosan Nanocomplexes for the Delivery of ENaC Antisense Oligonucleotides to Airway Epithelial Cells.,https://pubmed.ncbi.nlm.nih.gov/32260534/,4. Discussion > 4.2. Supplemented Transfection Medium Stabilizes Nanocomplexes but Harms Human Respiratory Epithelial Cells; paragraph 34,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=4. Discussion > 4.2. Supplemented Transfection Medium Stabilizes Nanocomplexes but Harms Human Respiratory Epithelial Cells; paragraph 34.,,,,,,,,TRUE
iv-release-0044,release_accept,release_accept/toxicity_endpoint/A/no,toxicity,toxicity_endpoint,166,A,no,185,unspecified siRNA,siRNA,,hepatic: hepatotoxicity,1613,36191773,PMC10695009manuscript-id: NIHMS1944143,10.1016/j.actbio.2022.09.065,Development of amino acid-modified biodegradable lipid nanoparticles for siRNA delivery.,https://pubmed.ncbi.nlm.nih.gov/36191773/,"Results and discussion > Characterization of LHHK LNPs for morphology, toxicity, serum stability, and hemolytic assay; paragraph 33",,accept,machine_precurated_v1,"accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Results and discussion > Characterization of LHHK LNPs for morphology, toxicity, serum stability, and hemolytic assay; paragraph 33.",,,,,,,,TRUE
iv-release-0045,release_accept,release_accept/toxicity_endpoint/A/no,toxicity,toxicity_endpoint,423,A,no,379,CaP-siSlc31a1,siRNA,SLC31A1,general safety: cell viability/cytotoxicity,1735,41809386,PMC12969650,10.1016/j.mtbio.2026.102991,Transdermal siRNA delivery via biomineralized nanoparticle-incorporated microneedles modulates cuproptosis-ferroptosis interaction for psoriasis therapy.,https://pubmed.ncbi.nlm.nih.gov/41809386/,Results and discussion > Fabrication of CaP-siSlc31a1 for efficient cellular uptake and gene silencing; paragraph 13,,accept,machine_precurated_v1,accepted: verified Results biocompatibility evidence for CaP-siSlc31a1; formulation showed lower cytotoxicity than liposomal comparator and maintained over 80% cell viability.,,,,,,,,TRUE
iv-release-0046,release_accept,release_accept/toxicity_endpoint/A/no,toxicity,toxicity_endpoint,1297,A,no,986,"unspecified ASO (v1 extraction artefact, pending source re-verification)",ASO,,hepatic: hepatotoxicity,12621,30114557,PMC6092551,10.1016/j.omtn.2018.07.010,Splice-Modulating Oligonucleotide QR-110 Restores CEP290 mRNA and Function in Human c.2991+1655A>G LCA10 Models.,https://pubmed.ncbi.nlm.nih.gov/30114557/,Results > Identification of Lead Oligonucleotide Targeting the CEP290 c.2991+1655A>G Mutation; paragraph 6,,accept,machine_precurated_v1,Verified full text evidence at Results > Identification of Lead Oligonucleotide Targeting the CEP290 c.2991+1655A>G Mutation; paragraph 6: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0047,release_accept,release_accept/toxicity_endpoint/A/no,toxicity,toxicity_endpoint,213,A,no,185,unspecified siRNA,siRNA,,hepatic: hepatotoxicity,3614,40616527,PMC12269356,10.1021/acsnano.5c05395,Reprogramming Immunodeficiency in Lung Metastases via PD-L1 siRNA Delivery and Antigen Capture of Nanosponge-Mediated Dendritic Cell Modulation.,https://pubmed.ncbi.nlm.nih.gov/40616527/,Results and Discussion > In Vivo GFP-pDNA Delivery by TP-SL@PB; paragraph 46,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Results and Discussion > In Vivo GFP-pDNA Delivery by TP-SL@PB; paragraph 46.,,,,,,,,TRUE
iv-release-0048,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,475,A,yes,494,unspecified ASO,ASO,,hepatic: hepatotoxicity,1055,42095135,PMC13140060,10.1016/j.omtn.2026.102930,Development of an exon 27-skipping antisense oligonucleotide as a targeted therapy for refractory skin ulcers in Werner syndrome.,https://pubmed.ncbi.nlm.nih.gov/42095135/,Results > Safety evaluation; paragraph 25,,accept,machine_precurated_v1,Verified full text evidence at Results > Safety evaluation; paragraph 25: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0049,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,660,A,yes,1038,unspecified ASO (PMID:35861704),ASO,,hepatic: hepatotoxicity,1485,35861704,PMC9595634,10.1089/nat.2022.0005,The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs.,https://pubmed.ncbi.nlm.nih.gov/35861704/,"Results > MsPA backbone improves potency, whereas gap2 OMe reduces toxicity in cytotoxic PS ASOs; FIG. 1. caption",,accept,machine_precurated_v1,"Verified full text evidence at Results > MsPA backbone improves potency, whereas gap2 OMe reduces toxicity in cytotoxic PS ASOs; FIG. 1. caption: primary toxicity support for hepatotoxicity in an oligonucleotide context.",,,,,,,,TRUE
iv-release-0050,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,514,A,yes,986,"unspecified ASO (v1 extraction artefact, pending source re-verification)",ASO,,hepatic: hepatotoxicity,1233,40926414,PMC12703169,10.1016/j.ymthe.2025.08.045,Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides.,https://pubmed.ncbi.nlm.nih.gov/40926414/,Results > Subcutaneous administration allows for optimal distribution and is not toxic to mice; paragraph 14,,accept,machine_precurated_v1,Verified full text evidence at Results > Subcutaneous administration allows for optimal distribution and is not toxic to mice; paragraph 14: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0051,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,1244,A,yes,1062,"SMN7D(-10-29) AO (recovered B2 from PMID:35464859, curator:CM)",ASO,,hepatic: hepatotoxicity,2210,35464859,PMC9019733,10.3389/fgene.2022.791416,"Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro.",https://pubmed.ncbi.nlm.nih.gov/35464859/,"Results > PMOs, or Double-Stranded 2′ O-methyl Phosphorothioate AOs, Do Not Form Nuclear Inclusions, Protecting From Cellular Toxicity and Off-Target Transcript Effects; paragraph 53",,accept,machine_precurated_v1,"Verified full text evidence at Results > PMOs, or Double-Stranded 2′ O-methyl Phosphorothioate AOs, Do Not Form Nuclear Inclusions, Protecting From Cellular Toxicity and Off-Target Transcript Effects; paragraph 53: primary toxicity support for hepatotoxicity in an oligonucleotide context.",,,,,,,,TRUE
iv-release-0052,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,2,A,yes,15,tool ASO safety panel from PMID 41918821,ASO,,hepatic: hepatotoxicity,1035,41918821,PMC13034028,10.1093/narmme/ugag016,Integrating transcriptomics and proteomics to assess antisense oligonucleotide safety and efficacy: a time-resolved approach.,https://pubmed.ncbi.nlm.nih.gov/41918821/,Results > Tool ASO safety profile characterization in vitro and in vivo; paragraph 32,,accept,curator_verified,"Safety characterization is based on in vitro, in vivo, and clinical data from literature and an in-house study where ALT levels were measured in an acute tolerability study in male BALB/c mice administered with 150 mg/kg ASO by subcutaneous injection.",,,,,,,,TRUE
iv-release-0053,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,441,A,yes,397,cationic/anionic siRNA lipoplexes,siRNA,,general safety: cell viability/cytotoxicity,12337,41282509,PMC12635908,10.3892/br.2025.2085,Assessment of anionic siRNA lipoplexes prepared via modified ethanol injection for tumor cell delivery.,https://pubmed.ncbi.nlm.nih.gov/41282509/,Results > Cytotoxicity of cationic and anionic siRNA lipoplexes; paragraph 27,,accept,machine_precurated_v1,accepted: verified Results cytotoxicity measurements for cationic and anionic siRNA lipoplex formulations in MCF-7-Luc and HeLa-Luc cells.,,,,,,,,TRUE
iv-release-0054,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,648,A,yes,1033,unspecified ASO (PMID:37704069),ASO,,hepatic: hepatotoxicity,12175,37704069,PMC10591917manuscript-id: NIHMS1931813,10.1016/j.bone.2023.116898,Antisense oligonucleotides targeting a NOTCH3 mutation in male mice ameliorate the cortical osteopenia of lateral meningocele syndrome.,https://pubmed.ncbi.nlm.nih.gov/37704069/,RESULTS > Effect of Notch3 ASOs on Notch3 Expression in Cells of the Osteoblast Lineage; paragraph 17,,accept,machine_precurated_v1,Verified full text evidence at RESULTS > Effect of Notch3 ASOs on Notch3 Expression in Cells of the Osteoblast Lineage; paragraph 17: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0055,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,974,A,yes,994,"S9 (recovered B2 from PMID:41552385, curator:CM)",siRNA,,hepatic: hepatotoxicity,3301,41552385,PMC12804371,10.1016/j.omtn.2025.102802,An acyclic nucleic acid-modified siRNA targeting CAG expansions for polyglutamine disease treatment.,https://pubmed.ncbi.nlm.nih.gov/41552385/,Results > S9-SNA ameliorated the phenotype of SBMA mice; paragraph 12,,accept,machine_precurated_v1,Verified full text evidence at Results > S9-SNA ameliorated the phenotype of SBMA mice; paragraph 12: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0056,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,70,A,yes,85,siRNA candidate from PMID 40692538,siRNA,,hematologic: platelet/bleeding safety,1242,40692538,PMC12277184,10.2147/IJN.S510937,Protective Effects of GalNac-Modified Red Blood Cell-Derived Extracellular Vesicles Against Liver Diseases.,https://pubmed.ncbi.nlm.nih.gov/40692538/,Results > Drugs-Loaded GalNac-RBC-EVs Were Non-Toxic to Mice; paragraph 42,,accept,machine_precurated_v1,PMC full text checked; verified source supports platelet/bleeding safety evidence.,,,,,,,,TRUE
iv-release-0057,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,457,A,yes,413,TPNs-siRNA,siRNA,MMP-2/MMP-9,general safety: systemic safety/tolerability,12485,39118143,PMC11308685,10.1186/s12951-024-02756-2,Tea polyphenol nanoparticles enable targeted siRNA delivery and multi-bioactive therapy for abdominal aortic aneurysms.,https://pubmed.ncbi.nlm.nih.gov/39118143/,Results and discussion > Safety assessment of TPNs-siRNA; paragraph 67,,accept,machine_precurated_v1,"Verified full-text Safety assessment: TPNs-siRNA hemolysis remained below 5%, body weight and organ indices were unchanged, and serum chemistry/H&E supported systemic tolerability.",,,,,,,,TRUE
iv-release-0058,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,529,A,yes,1014,"D-siRNA (recovered B2 from PMID:41473322, curator:CM)",siRNA,,hepatic: hepatotoxicity,3402,41473322,PMC12746015,10.64898/2025.12.16.694641,Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system.,https://pubmed.ncbi.nlm.nih.gov/41473322/,"RESULTS > D-siRNA supports safe, potent and durable activity in the CNS; paragraph 24",,accept,machine_precurated_v1,"Verified full text evidence at RESULTS > D-siRNA supports safe, potent and durable activity in the CNS; paragraph 24: primary toxicity support for hepatotoxicity in an oligonucleotide context.",,,,,,,,TRUE
iv-release-0059,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,513,A,yes,1011,"ASO 8–3 (recovered B2 from PMID:40098305, curator:CM)",ASO,,hepatic: hepatotoxicity,1020,40098305,PMC12044654,10.1111/cas.70024,AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds.,https://pubmed.ncbi.nlm.nih.gov/40098305/,Results > ASO 8–3419 Enhances the Therapeutic Effect of Cisplatin in Xenografted HCT116 Tumors in Nude Mice; paragraph 26,,accept,machine_precurated_v1,Verified full text evidence at Results > ASO 8–3419 Enhances the Therapeutic Effect of Cisplatin in Xenografted HCT116 Tumors in Nude Mice; paragraph 26: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0060,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,451,A,yes,407,PLGA-CpG@ID8-M nanovaccine,CpG oligodeoxynucleotide,,general safety: cell viability/cytotoxicity,13359,39985265,PMC12005807,10.1002/advs.202412881,CpG-Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2-Mediated Remodeling of Tumor-Associated Macrophages.,https://pubmed.ncbi.nlm.nih.gov/39985265/,"Results and Discussion > Synthesis, Characterization, and Safety Assessment of PLGA-CpG@ID8-M Nanovaccine; paragraph 9",,accept,machine_precurated_v1,"Verified full-text Safety Assessment: PLGA-CpG@ID8-M and free CpG did not significantly affect RAW264.7 viability at 0-2 uM, and 0.5 uM nanovaccine showed no long-term cytotoxicity in BMDMs.",,,,,,,,TRUE
iv-release-0061,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,84,A,yes,99,Inotersen,ASO/siRNA mixed context,,hematologic: platelet/bleeding safety,1658,32343462,PMC7496583,10.1111/ene.14285,Early data on long-term efficacy and safety of inotersen in patients with hereditary transthyretin amyloidosis: a 2-year update from the open-label extension of the NEURO-TTR trial.,https://pubmed.ncbi.nlm.nih.gov/32343462/,Results > Safety and tolerability > Thrombocytopenia and glomerulonephritis; paragraph 30,,accept,machine_precurated_v1,PMC full text checked; verified source supports platelet/bleeding safety evidence.,,,,,,,,TRUE
iv-release-0062,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,548,A,yes,435,siRNAs,siRNA,,hepatic: hepatotoxicity,3801,39632755,PMC11704396,10.4062/biomolther.2024.071,"Design, Screening and Development of Asymmetric siRNAs Targeting the MYC Oncogene in Triple-Negative Breast Cancer.",https://pubmed.ncbi.nlm.nih.gov/39632755/,RESULTS > Reduced 5’ end- and -2’- fluoro modification design; paragraph 37,,accept,machine_precurated_v1,Verified full text evidence at RESULTS > Reduced 5’ end- and -2’- fluoro modification design; paragraph 37: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0063,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,658,A,yes,1036,"DG9-PMO (recovered B2 from PMID:36719755, curator:CM)",PMO,,immunotoxicity: immune activation,14276,36719755,PMC10077475,10.1172/jci.insight.160516,DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration.,https://pubmed.ncbi.nlm.nih.gov/36719755/,Results > DG9-PMO treatment rescues the SMA phenotype without apparent toxicity.; paragraph 19,,accept,machine_precurated_v1,Verified full text evidence at Results > DG9-PMO treatment rescues the SMA phenotype without apparent toxicity.; paragraph 19: primary toxicity support for immune activation in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0064,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,229,A,yes,244,inclisiran,ASO/siRNA mixed context,,general safety: safety/tolerability,2676,37252442,PMC10209488,10.1016/j.ajpc.2023.100503,"Efficacy and safety of inclisiran in patients with cerebrovascular disease: ORION-9, ORION-10, and ORION-11.",https://pubmed.ncbi.nlm.nih.gov/37252442/,Results > Safety outcomes; paragraph 13,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for safety/tolerability; location=Results > Safety outcomes; paragraph 13.,,,,,,,,TRUE
iv-release-0065,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,453,A,yes,409,Ube3a-AS ASO,ASO,Ube3a-AS,hepatic: hepatotoxicity,2614,38327047,PMC11163203,10.1016/j.ymthe.2024.02.004,Prenatal delivery of a therapeutic antisense oligonucleotide achieves broad biodistribution in the brain and ameliorates Angelman syndrome phenotype in mice.,https://pubmed.ncbi.nlm.nih.gov/38327047/,Results > Analysis of potential toxicities of ASO exposure in dams; paragraph 15,,accept,machine_precurated_v1,"Verified full-text toxicity analysis: blinded liver pathology found no maternal or pup liver pathology, while maternal serum testing detected AST elevation/trend after in utero ASO exposure with other liver markers similar.",,,,,,,,TRUE
iv-release-0066,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,1117,A,yes,986,"unspecified ASO (v1 extraction artefact, pending source re-verification)",ASO,,hepatic: hepatotoxicity,10025,40024534,PMC12022666,10.1016/j.jcmgh.2025.101485,Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular Carcinoma.,https://pubmed.ncbi.nlm.nih.gov/40024534/,Results > Stk25-Targeting ASO Therapy Hinders the Development and Progression of MASH-Related HCC in a Mouse Model; paragraph 16,,accept,machine_precurated_v1,Verified full text evidence at Results > Stk25-Targeting ASO Therapy Hinders the Development and Progression of MASH-Related HCC in a Mouse Model; paragraph 16: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0067,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,1161,A,yes,231,givosiran,siRNA,,hepatic: hepatotoxicity,10566,39597922,PMC11594983,10.3390/jcm13226779,German Real-World Experience of Patients with Diverse Features of Acute Intermittent Porphyria Treated with Givosiran.,https://pubmed.ncbi.nlm.nih.gov/39597922/,3. Results > 3.4. Safety > Adverse Events; paragraph 37,,accept,machine_precurated_v1,Verified full text evidence at 3. Results > 3.4. Safety > Adverse Events; paragraph 37: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0068,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,244,A,yes,252,nusinersen,ASO/siRNA mixed context,,general safety: safety/tolerability,2611,38361750,PMC10864329,10.1016/j.lanepe.2024.100862,Long-term efficacy and safety of nusinersen in adults with 5q spinal muscular atrophy: a prospective European multinational observational study.,https://pubmed.ncbi.nlm.nih.gov/38361750/,Results; paragraph 15,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for safety/tolerability; location=Results; paragraph 15.,,,,,,,,TRUE
iv-release-0069,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,1247,A,yes,1063,"PC-DCA siRNA (recovered B2 from PMID:35847173, curator:CM)",siRNA,,hepatic: hepatotoxicity,4069,35847173,PMC9263991,10.1016/j.omtn.2022.06.009,Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.,https://pubmed.ncbi.nlm.nih.gov/35847173/,Results > Systematic chemical optimization of sFLT1-targeting siRNAs improves placental accumulation and degree of sFLT1 silencing with a better safety profile; paragraph 30,,accept,machine_precurated_v1,Verified full text evidence at Results > Systematic chemical optimization of sFLT1-targeting siRNAs improves placental accumulation and degree of sFLT1 silencing with a better safety profile; paragraph 30: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0070,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,110,A,yes,130,Nedosiran,ASO/siRNA mixed context,,renal: renal safety,10207,39875734,PMC12031765,10.1007/s00467-025-06675-8,"Nedosiran in pediatric patients with PH1 and relatively preserved kidney function, a phase 2 study (PHYOX8).",https://pubmed.ncbi.nlm.nih.gov/39875734/,Results > Safety; paragraph 24,,accept,machine_precurated_v1,PMC full text checked; verified source supports renal safety evidence.,,,,,,,,TRUE
iv-release-0071,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,114,A,yes,132,Viltolarsen,ASO,,general safety: safety/tolerability,1621,35634851,PMC9398057,10.3233/JND-220811,Long-Term Functional Efficacy and Safety of Viltolarsen in Patients with Duchenne Muscular Dystrophy.,https://pubmed.ncbi.nlm.nih.gov/35634851/,RESULTS > Safety; paragraph 21,,accept,machine_precurated_v1,PMC full text checked; verified source supports safety/tolerability evidence.,,,,,,,,TRUE
iv-release-0072,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,450,A,yes,406,PEI/PHD2 siRNA nanocomplexes,siRNA,PHD2,general safety: cell viability/cytotoxicity,12938,41266661,PMC12634668,10.1038/s41598-025-24808-9,Optimized delivery of RNA silencing prolyl hydroxylase domain 2 for enhanced angiogenesis and osteogenesis using bioactive glass scaffolds.,https://pubmed.ncbi.nlm.nih.gov/41266661/,Results > Biological effects of PEI/PHD2 SiRNA complexes on HUVECs; paragraph 36,,accept,machine_precurated_v1,Verified full-text Results: HUVEC viability remained above 90% after exposure to PEI/PHD2 siRNA nanocomplexes and no significant cytotoxicity differences were observed.,,,,,,,,TRUE
iv-release-0073,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,531,A,yes,525,elebsiran,siRNA,,hepatic: hepatotoxicity,3426,41326382,PMC12780110,10.1038/s41467-025-66876-5,An RNA interference therapeutic potentially achieves functional cure of chronic hepatitis B virus infection.,https://pubmed.ncbi.nlm.nih.gov/41326382/,Results > Safety profiles of KC13-M2G2 in SD rats and cynomolgus monkeys; paragraph 19,,accept,machine_precurated_v1,Verified full text evidence at Results > Safety profiles of KC13-M2G2 in SD rats and cynomolgus monkeys; paragraph 19: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0074,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,96,A,yes,114,Angptl4-targeting ASO from PMID 39259836,ASO,,immunotoxicity: immune activation,1565,39259836,PMC11687395,10.1093/cvr/cvae195,Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice.,https://pubmed.ncbi.nlm.nih.gov/39259836/,Results > Short-term liver-targeted Angptl3 and Angptl4 silencing does not induce hepatic inflammation; paragraph 27,,accept,machine_precurated_v1,PMC full text checked; verified source supports immune activation evidence.,,,,,,,,TRUE
iv-release-0075,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,522,A,yes,1013,"iExoKrasG12D (recovered B2 from PMID:41027940, curator:CM)",siRNA,,hepatic: hepatotoxicity,1803,41027940,PMC12485160,10.1038/s41467-025-63718-2,Engineered exosomes with Kras(G12D) specific siRNA in pancreatic cancer: a phase I study with immunological correlates.,https://pubmed.ncbi.nlm.nih.gov/41027940/,Results > GMP grade exosomes for siRNA delivery showed no toxicity in preclinical studies; paragraph 6,,accept,machine_precurated_v1,Verified full text evidence at Results > GMP grade exosomes for siRNA delivery showed no toxicity in preclinical studies; paragraph 6: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0076,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,578,A,yes,1021,"DG9-PMO (recovered B2 from PMID:40368879, curator:CM)",PMO,,hepatic: hepatotoxicity,9560,40368879,PMC12078682,10.1038/s41467-025-59494-8,DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function.,https://pubmed.ncbi.nlm.nih.gov/40368879/,Results > DG9-PMO facilitates enhanced cellular uptake and efficacious nuclear localization; paragraph 9,,accept,machine_precurated_v1,Verified full text evidence at Results > DG9-PMO facilitates enhanced cellular uptake and efficacious nuclear localization; paragraph 9: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0077,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,695,A,yes,1047,"NVP-13 (recovered B2 from PMID:32178467, curator:CM)",ASO,,hepatic: hepatotoxicity,1492,32178467,PMC7139664,10.3390/ijms21061952,Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.,https://pubmed.ncbi.nlm.nih.gov/32178467/,2. Results > 2.1. Discovery Process; paragraph 7,,accept,machine_precurated_v1,Verified full text evidence at 2. Results > 2.1. Discovery Process; paragraph 7: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0078,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,544,A,yes,1018,unspecified siRNA (PMID:40143003),siRNA,,general safety: cell viability/cytotoxicity,3725,40143003,PMC11946471,10.3390/pharmaceutics17030339,Analysis of Polymer/siRNA Nanoparticle Efficacy and Biocompatibility in 3D Air-Liquid Interface Culture Compared to 2D Cell Culture.,https://pubmed.ncbi.nlm.nih.gov/40143003/,2. Materials and Methods > 2.8. Acute Toxicity (LDH Release); paragraph 25,,accept,machine_precurated_v1,Verified full text evidence at 2. Materials and Methods > 2.8. Acute Toxicity (LDH Release); paragraph 25: primary toxicity support for cell viability/cytotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0079,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,12,A,yes,26,RGLS4326 anti-miR-17 ASO,ASO,MIR17,neurological: neurotoxicity,1410,41315228,PMC12663328,10.1038/s41467-025-65799-5,The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity.,https://pubmed.ncbi.nlm.nih.gov/41315228/,Results > CNS toxicity after RGLS4326 treatment in nonclinical toxicity studies; paragraph 7,,accept,machine_precurated_v1,PMC full text checked; Results paragraph reports dose-related CNS toxicity signs and mortality after RGLS4326 administration.,,,,,,,,TRUE
iv-release-0080,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,60,A,yes,74,GalNAc-siRNA hepatotoxicity panel with REVERSIR from PMID 29459660,siRNA,HAO1; TTR,hepatic: hepatotoxicity,2058,29459660,PMC5818625,10.1038/s41467-018-02989-4,Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.,https://pubmed.ncbi.nlm.nih.gov/29459660/,Results > Blocking siRNA-loaded RISC activity mitigates hepatotoxicity; paragraph 12,,accept,machine_precurated_v1,PMC full text checked; Results paragraph shows blocking siRNA-loaded RISC mitigates off-target-driven rat hepatotoxicity.,,,,,,,,TRUE
iv-release-0081,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,543,A,yes,1017,"HSA@ICG/siRNA NPs (recovered B2 from PMID:40259913, curator:CM)",siRNA,,hepatic: hepatotoxicity,3710,40259913,PMC12010081,10.2147/IJN.S511655,NIR-Triggered siRNA Release and Lysosomal Escape for Synergistic Photothermal Tumor Therapy.,https://pubmed.ncbi.nlm.nih.gov/40259913/,Results > Anti-Tumor Efficacy and Safety Evaluation in Vivo; paragraph 63,,accept,machine_precurated_v1,Verified full text evidence at Results > Anti-Tumor Efficacy and Safety Evaluation in Vivo; paragraph 63: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0082,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,640,A,yes,185,unspecified siRNA,siRNA,,general safety: cell viability/cytotoxicity,1292,37834294,PMC10573891,10.3390/ijms241914846,Antiviral Efficacy of RNase H-Dependent Gapmer Antisense Oligonucleotides against Japanese Encephalitis Virus.,https://pubmed.ncbi.nlm.nih.gov/37834294/,4. Materials and Methods > 4.8. Cytotoxicity Assay; paragraph 37,,accept,machine_precurated_v1,Verified full text evidence at 4. Materials and Methods > 4.8. Cytotoxicity Assay; paragraph 37: primary toxicity support for cell viability/cytotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0083,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,461,A,yes,417,MPLN siRNA nanoparticles,siRNA,,general safety: cell viability/cytotoxicity,12533,36755201,PMC10074117,10.1002/advs.202300282,Lymphocyte Membrane- and 12p1-Dual-Functionalized Nanoparticles for Free HIV-1 Trapping and Precise siRNA Delivery into HIV-1-Infected Cells.,https://pubmed.ncbi.nlm.nih.gov/36755201/,Results > Cytotoxicity; paragraph 19,,accept,machine_precurated_v1,"Verified full-text Cytotoxicity Results: MLN/MPLN treatment did not significantly change viability in TZM-bl, MT2, or PBMC cultures compared with control.",,,,,,,,TRUE
iv-release-0084,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,1060,A,yes,652,Single-dose,siRNA,,general safety: systemic safety/tolerability,3717,40196492,PMC11974818,10.1101/2025.03.26.645328,Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model.,https://pubmed.ncbi.nlm.nih.gov/40196492/,RESULTS > Single injection of non-isoform selective 1764_S1 but not E1 selective 112_S1 induces mixed behavioral effects in Tg1 mice; paragraph 36,,accept,machine_precurated_v1,Verified full text evidence at RESULTS > Single injection of non-isoform selective 1764_S1 but not E1 selective 112_S1 induces mixed behavioral effects in Tg1 mice; paragraph 36: primary toxicity support for systemic safety/tolerability in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0085,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,530,A,yes,435,siRNAs,siRNA,,hepatic: hepatotoxicity,3407,41432033,PMC12723224,10.1093/nar/gkaf1374,Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs.,https://pubmed.ncbi.nlm.nih.gov/41432033/,Results > Muscle-optimal siRNA scaffold achieves systemic muscle effects and has a favorable safety profile; Figure 6. caption,,accept,machine_precurated_v1,Verified full text evidence at Results > Muscle-optimal siRNA scaffold achieves systemic muscle effects and has a favorable safety profile; Figure 6. caption: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0086,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,731,A,yes,578,DUX4,PMO,,hepatic: hepatotoxicity,15206,27378237,PMC5023379,10.1038/mt.2016.111,Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics.,https://pubmed.ncbi.nlm.nih.gov/27378237/,Results; paragraph 6,,accept,machine_precurated_v1,Verified full text evidence at Results; paragraph 6: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0087,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,13,A,yes,27,SNS812,siRNA,SARS-CoV-2 RdRP,general safety: safety/tolerability,2286,40116355,PMC11926758,10.1111/cts.70202,"Pharmacokinetics and Safety Profile of SNS812, a First in Human Fully Modified siRNA Targeting Wide-Spectrum SARS-CoV-2, in Healthy Subjects.",https://pubmed.ncbi.nlm.nih.gov/40116355/,Results > Primary Efficacy: Safety; paragraph 27,,accept,machine_precurated_v1,PMC full text checked; Results safety section reports TEAEs after single- and multiple-dose inhaled SNS812 in healthy participants.,,,,,,,,TRUE
iv-release-0088,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,1293,A,yes,435,siRNAs,siRNA,,hepatic: hepatotoxicity,12616,30535404,PMC6379714,10.1093/nar/gky1232,Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.,https://pubmed.ncbi.nlm.nih.gov/30535404/,RESULTS > Lipid-hsiRNAs elicit sustained systemic in vivo gene silencing after a single injection > Liver; paragraph 26,,accept,machine_precurated_v1,Verified full text evidence at RESULTS > Lipid-hsiRNAs elicit sustained systemic in vivo gene silencing after a single injection > Liver; paragraph 26: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0089,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,449,A,yes,405,BE-ST@siBACE1 / BE-ST@siRNA,siRNA,BACE1,immunotoxicity: immune activation,9961,40064874,PMC11893799,10.1038/s41467-025-57488-0,Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics.,https://pubmed.ncbi.nlm.nih.gov/40064874/,Results > Brain-targeted delivery of siBACE1 by BE-ST for AD treatment; paragraph 18,,accept,machine_precurated_v1,"Verified full-text Results: blood biochemistry and histology were unchanged versus PBS and C5b9, C3a, and MCP-1 immunogenicity markers remained stable after BE-ST@siRNA treatment.",,,,,,,,TRUE
iv-release-0090,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,187,A,yes,205,drisapersen,ASO/siRNA mixed context,,hepatic: hepatotoxicity,2328,24321374,PMC4145871manuscript-id: NIHMS592631,10.1016/j.nmd.2013.09.004,Pharmacokinetics and safety of single doses of drisapersen in non-ambulant subjects with Duchenne muscular dystrophy: results of a double-blind randomized clinical trial.,https://pubmed.ncbi.nlm.nih.gov/24321374/,3. Results > 3.2. Safety results; paragraph 15,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=3. Results > 3.2. Safety results; paragraph 15.,,,,,,,,TRUE
iv-release-0091,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,520,A,yes,1012,"Chol-HDO[PMO] (recovered B2 from PMID:41429785, curator:CM)",PMO,,hepatic: hepatotoxicity,1783,41429785,PMC12722745,10.1038/s41467-025-66765-x,"Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection.",https://pubmed.ncbi.nlm.nih.gov/41429785/,Results > Safety evaluation of Chol-HDO[PMO]; paragraph 27,,accept,machine_precurated_v1,Verified full text evidence at Results > Safety evaluation of Chol-HDO[PMO]; paragraph 27: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0092,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,481,A,yes,1008,"siRNA2 (recovered B2 from PMID:42005705, curator:CM)",siRNA,,hepatic: hepatotoxicity,1368,42005705,PMC13091633,10.2147/IJN.S588018,Preparation and Antitumor Activity of METTL3 SiRNA Nanoparticles Carried by Hypoxia Sensitive Polymer (mPEG-Azo-PEI).,https://pubmed.ncbi.nlm.nih.gov/42005705/,Results > Cytotoxicity of mPEG-Azo-PEI; paragraph 50,,accept,machine_precurated_v1,Verified full text evidence at Results > Cytotoxicity of mPEG-Azo-PEI; paragraph 50: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0093,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,463,A,yes,419,CS-OA coated PLGA siRNA nanoparticles,siRNA,,general safety: cell viability/cytotoxicity,4114,34684009,PMC8539707,10.3390/pharmaceutics13101716,Chitosan Oleate Coated PLGA Nanoparticles as siRNA Drug Delivery System.,https://pubmed.ncbi.nlm.nih.gov/34684009/,3. Results and Discussion > 3.4. Cytotoxicity Test on Human CD14+ Monocytes from Peripheral Blood; paragraph 23,,accept,machine_precurated_v1,"Verified full-text Cytotoxicity Results: CS-OA coated nanoparticles did not affect viability of human CD14+ peripheral-blood monocytes, including at the highest tested concentration.",,,,,,,,TRUE
iv-release-0094,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,61,A,yes,75,236-LNA-ASO hepatotoxicity screening panel from PMID 29499955,ASO,,hepatic: hepatotoxicity,2319,29499955,PMC5725219,10.1016/j.omtn.2017.11.004,A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides.,https://pubmed.ncbi.nlm.nih.gov/29499955/,Results > Apoptosis Induction by Hepatotoxic LNA-ASOs In Vitro Is RNase H1 Dependent; paragraph 8,,accept,machine_precurated_v1,PMC full text checked; Results paragraph reports an in vitro apoptosis assay linked to hepatotoxic LNA-ASOs.,,,,,,,,TRUE
iv-release-0095,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,59,A,yes,73,GalNAc AON-B/D/E panel from PMID 30583097,ASO,,renal: renal safety,2059,30583097,PMC6305803,10.1016/j.omtn.2018.11.005,GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.,https://pubmed.ncbi.nlm.nih.gov/30583097/,Results > GalNAc Conjugation Masked the In Vivo Nephrotoxicity Potential of AON Drug Candidates; paragraph 7,,accept,machine_precurated_v1,PMC full text checked; Results paragraph directly demonstrates GalNAc attenuation of AON nephrotoxicity potential.,,,,,,,,TRUE
iv-release-0096,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,24,A,yes,38,G-clamp/BNAP-AEO modified Malat1 ASO panel from PMID 38978695,ASO,MALAT1,neurological: neurotoxicity,1110,38978695,PMC11229412,10.1016/j.omtn.2024.102161,"Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine.",https://pubmed.ncbi.nlm.nih.gov/38978695/,Results > G-clamp modification in ASO targeting Malat1 RNA mitigates acute CNS toxicity of ASO; paragraph 11,,accept,machine_precurated_v1,PMC full text checked; Results paragraph directly reports reduced acute CNS toxicity from ASO chemical modification.,,,,,,,,TRUE
iv-release-0097,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,414,A,yes,371,Inclisiran,siRNA,PCSK9,general safety: clinical laboratory safety,2498,40391436,PMC12180692,10.1161/CIRCULATIONAHA.124.073233,"Efficacy and Safety of Inclisiran in Adolescents With Genetically Confirmed Homozygous Familial Hypercholesterolemia: Results From the Double-Blind, Placebo-Controlled Part of the ORION-13 Randomized Trial.",https://pubmed.ncbi.nlm.nih.gov/40391436/,RESULTS > Safety Analysis; paragraph 36,,accept,machine_precurated_v1,"accepted: verified ORION-13 clinical safety results for inclisiran; no ALT/AST, bilirubin, creatinine, CK, growth, puberty, or hormonal safety abnormalities were reported at the checked Results safety location.",,,,,,,,TRUE
iv-release-0098,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,440,A,yes,396,SANG-siRNA,siRNA,,general safety: systemic toxicity/repeat-dose tolerability,6833,41500988,PMC12780282,10.1038/s41467-025-66788-4,Tumor agnostic drug delivery with dynamic nanohydrogels.,https://pubmed.ncbi.nlm.nih.gov/41500988/,Results > Systemic delivery of SANGs is minimally toxic; paragraph 20,,accept,machine_precurated_v1,accepted: verified Results systemic delivery safety for scrambled miRNA/siRNA-loaded SANGs; high-dose and repeat-dose studies reported no significant toxicity.,,,,,,,,TRUE
iv-release-0099,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,1043,A,yes,986,"unspecified ASO (v1 extraction artefact, pending source re-verification)",ASO,,hematological: thrombocytopenia,1828,40599554,PMC12208382,10.1097/CP9.0000000000000122,Rats subject to extracorporeal membrane oxygenation have improved cardiac function following anticoagulation and reversal with factor IXa aptamer-antidote oligonucleotide pair.,https://pubmed.ncbi.nlm.nih.gov/40599554/,Abstract > Results:; paragraph 3,,accept,machine_precurated_v1,Verified full text evidence at Abstract > Results:; paragraph 3: primary toxicity support for thrombocytopenia in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0100,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,670,A,yes,1043,unspecified siRNA (PMID:36457549),siRNA,,hepatic: hepatotoxicity,4051,36457549,PMC9707323,10.2147/IJN.S383862,Combined Self-Assembled iRGD Polymersomes for Effective Targeted siRNA Anti-Tumor Therapy.,https://pubmed.ncbi.nlm.nih.gov/36457549/,Materials and Methods > The Cytotoxicity Studies of iRGD Functionalized Lipopolysaccharide-Amine Nanopolymersomes to Mesenchymal Stem Cells; paragraph 11,,accept,machine_precurated_v1,Verified full text evidence at Materials and Methods > The Cytotoxicity Studies of iRGD Functionalized Lipopolysaccharide-Amine Nanopolymersomes to Mesenchymal Stem Cells; paragraph 11: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0101,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,600,A,yes,1025,"ION-827359 (recovered B2 from PMID:39286058, curator:CM)",ASO,,hepatic: hepatotoxicity,1562,39286058,PMC11403593,10.1183/23120541.00986-2023,"Randomised, phase 1/2a trial of ION-827359, an antisense oligonucleotide inhibitor of ENaC.",https://pubmed.ncbi.nlm.nih.gov/39286058/,Methods > End-points > Safety; paragraph 13,,accept,machine_precurated_v1,Verified full text evidence at Methods > End-points > Safety; paragraph 13: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0102,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,48,A,yes,62,HsPCSK9-1811-LNA/GalNAc ASO panel from PMID 34760338,ASO,PCSK9,renal; hepatic: renal and hepatic safety,1632,34760338,PMC8560717,10.1016/j.omtn.2021.10.008,Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides.,https://pubmed.ncbi.nlm.nih.gov/34760338/,Results > Evaluating the safety of the GalNAc conjugate in rat; paragraph 15,,accept,machine_precurated_v1,PMC full text checked; Results paragraph reports renal and hepatic safety markers after LNA/GalNAc ASO dosing.,,,,,,,,TRUE
iv-release-0103,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,703,A,yes,563,Site-specific,ASO,,hepatic: hepatotoxicity,3148,31034558,PMC6582325,10.1093/nar/gkz247,Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.,https://pubmed.ncbi.nlm.nih.gov/31034558/,RESULTS > A single MOP linkage at position 2 in the DNA gap reduces toxicity for multiple ASOs; paragraph 46,,accept,machine_precurated_v1,Verified full text evidence at RESULTS > A single MOP linkage at position 2 in the DNA gap reduces toxicity for multiple ASOs; paragraph 46: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0104,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,38,A,yes,52,ASO1-ASO3 modified ASO panel from PMID 36700050,ASO,,neurological: neurotoxicity,12067,36700050,PMC9843489,10.1016/j.omtn.2022.12.010,Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route.,https://pubmed.ncbi.nlm.nih.gov/36700050/,Results > Effect of ASO oligonucleotide sequence and modifications on neurotoxicity; paragraph 16,,accept,machine_precurated_v1,PMC full text checked; Results paragraph directly links ASO sequence/modification to acute neurotoxicity.,,,,,,,,TRUE
iv-release-0105,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,25,A,yes,39,aCSF+-formulated CNS ASO/di-siRNA panel from PMID 39554992,ASO/siRNA mixed context,,neurological: neurotoxicity,1115,39554992,PMC11567125,10.1016/j.omtn.2024.102359,Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca(2+) and Mg(2+) in the formulation.,https://pubmed.ncbi.nlm.nih.gov/39554992/,Results > Using aCSF+ reduces the acute neurotoxicity of CNS-administered ASOs; paragraph 26,,accept,machine_precurated_v1,PMC full text checked; Results paragraph reports formulation-dependent prevention of acute neurotoxicity for CNS-administered oligonucleotides.,,,,,,,,TRUE
iv-release-0106,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,607,A,yes,1026,"aODN-Survivin (recovered B2 from PMID:38672408, curator:CM)",ASO,,hepatic: hepatotoxicity,3903,38672408,PMC11048556,10.3390/biom14040390,Synthesis and Validation of TRIFAPYs as a Family of Transfection Agents for Therapeutic Oligonucleotides.,https://pubmed.ncbi.nlm.nih.gov/38672408/,3. Results > 3.3. Intrinsic Toxicity and Transfection Efficiency of TRIFAPYs; paragraph 31,,accept,machine_precurated_v1,Verified full text evidence at 3. Results > 3.3. Intrinsic Toxicity and Transfection Efficiency of TRIFAPYs; paragraph 31: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0107,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,462,A,yes,418,ZNF416 siRNA-loaded liposomes,siRNA,ZNF416,general safety: systemic safety/tolerability,12545,36371191,PMC9652794,10.1186/s12967-022-03740-w,Targeted delivery of ZNF416 siRNA-loaded liposomes attenuates experimental pulmonary fibrosis.,https://pubmed.ncbi.nlm.nih.gov/36371191/,Results > Administration of ZNF416 siRNA-loaded liposomes attenuates pulmonary fibrosis in experimental mouse models; paragraph 41,,accept,machine_precurated_v1,"Verified full-text Results: ZNF416 siRNA-loaded liposomes entered fibroblasts without cytotoxicity and showed no significant ALT/AST/Scr/BUN/CK-MB, body-weight, or major-organ H&E changes versus controls.",,,,,,,,TRUE
iv-release-0108,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,608,A,yes,1027,unspecified siRNA (PMID:38617800),siRNA,,general safety: cell viability/cytotoxicity,3912,38617800,PMC11015852,10.2147/IJN.S443413,Microdroplets Encapsulated with NFATc1-siRNA and Exosomes-Derived from MSCs Onto 3D Porous PLA Scaffold for Regulating Osteoclastogenesis and Promoting Osteogenesis.,https://pubmed.ncbi.nlm.nih.gov/38617800/,Results > Biocompatibility Test of Different Scaffolds; paragraph 34,,accept,machine_precurated_v1,Verified full text evidence at Results > Biocompatibility Test of Different Scaffolds; paragraph 34: primary toxicity support for cell viability/cytotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0109,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,1141,A,yes,1058,"siTMEM45A (recovered B2 from PMID:39910045, curator:CM)",siRNA,,hepatic: hepatotoxicity,13436,39910045,PMC11799145,10.1038/s41420-025-02336-9,TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer.,https://pubmed.ncbi.nlm.nih.gov/39910045/,Results > Construction and characterization of the BRCA primary cell-derived engineered exosomes; paragraph 14,,accept,machine_precurated_v1,Verified full text evidence at Results > Construction and characterization of the BRCA primary cell-derived engineered exosomes; paragraph 14: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0110,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,1214,A,yes,1061,"si3033 (recovered B2 from PMID:37925520, curator:CM)",siRNA,,hepatic: hepatotoxicity,3979,37925520,PMC10625637,10.1038/s41467-023-42714-4,Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin.,https://pubmed.ncbi.nlm.nih.gov/37925520/,Results > si3033 has a good safety profile and enables JAK1 silencing in mouse skin over 5 weeks; paragraph 11,,accept,machine_precurated_v1,Verified full text evidence at Results > si3033 has a good safety profile and enables JAK1 silencing in mouse skin over 5 weeks; paragraph 11: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0111,release_accept,release_accept/toxicity_endpoint/A/yes,toxicity,toxicity_endpoint,602,A,yes,472,siRNA-mediated,siRNA,,hepatic: hepatotoxicity,2588,38779336,PMC11109470,10.1016/j.omtm.2024.101258,siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles.,https://pubmed.ncbi.nlm.nih.gov/38779336/,Results > siRNA-LNPs displayed a low risk of CARPA and other toxicities; paragraph 9,,accept,machine_precurated_v1,Verified full text evidence at Results > siRNA-LNPs displayed a low risk of CARPA and other toxicities; paragraph 9: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0112,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,905,B,no,985,"unspecified siRNA (v1 extraction artefact, pending source re-verification)",siRNA,,hepatic: hepatotoxicity,4042,36513186,,10.1016/j.jhep.2022.11.025,"A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis.",https://pubmed.ncbi.nlm.nih.gov/36513186/,PubMed abstract,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0113,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,183,B,no,202,RTR3649; RTR5001; RTR4955,ASO,,hepatic: hepatotoxicity,2324,28123102,PMC5414856,10.1093/toxsci/kfx025,From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.,https://pubmed.ncbi.nlm.nih.gov/28123102/,DISCUSSION; paragraph 65,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=DISCUSSION; paragraph 65.,,,,,,,,TRUE
iv-release-0114,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,1401,B,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,chemistry: VHP peptide modification targeted siRNA-exosome delivery,3325,41491215,PMC12781530,10.1186/s12951-025-03954-2,Endothelial-targeted modification of ginseng-derived exosomes for IL-6 SiRNA delivery ameliorates hepatic ischemia-reperfusion injury.,https://pubmed.ncbi.nlm.nih.gov/41491215/,PubMed abstract sentence 4,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for toxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0115,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,819,B,no,986,"unspecified ASO (v1 extraction artefact, pending source re-verification)",ASO,,hepatic: hepatotoxicity,1842,40280496,,10.1016/j.spinee.2025.04.021,NF-kappa B Oligo DNA decoy provides 12 months of pain relief and disc height restoration for patients with chronic discogenic low back pain-a randomized clinical trial.,https://pubmed.ncbi.nlm.nih.gov/40280496/,PubMed abstract,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0116,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,1408,B,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,chemistry: sgc8 aptamer conjugation improves siRNA nanoparticle targeting,12442,39583320,PMC11585994,10.2147/IJN.S477597,Aptamer sgc8-Modified PAMAM Nanoparticles for Targeted siRNA Delivery to Inhibit BCL11B in T-Cell Acute Lymphoblastic Leukemia.,https://pubmed.ncbi.nlm.nih.gov/39583320/,PubMed abstract sentence 5,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0117,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,218,B,no,235,APP36; Iba1,siRNA,,hepatic: hepatotoxicity,7646,41323796,PMC12663631,10.1016/j.omtn.2025.102757,SCAD: A modular platform for efficient delivery of duplex RNA to the CNS and beyond.,https://pubmed.ncbi.nlm.nih.gov/41323796/,Discussion; paragraph 46,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Discussion; paragraph 46.,,,,,,,,TRUE
iv-release-0118,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,325,B,no,311,pelacarsen,ASO,,hepatic: hepatotoxicity,12201,36529659,,10.1016/j.jacl.2022.12.001,Efficacy and safety of pelacarsen in lowering Lp(a) in healthy Japanese subjects.,https://pubmed.ncbi.nlm.nih.gov/36529659/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0119,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,170,B,no,191,SKOV3,siRNA,,hepatic: hepatotoxicity,4105,34382360,PMC11468224,10.1002/adhm.202101202,Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles.,https://pubmed.ncbi.nlm.nih.gov/34382360/,Discussion; paragraph 36,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Discussion; paragraph 36.,,,,,,,,TRUE
iv-release-0120,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,212,B,no,185,unspecified siRNA,siRNA,,hepatic: hepatotoxicity,3595,40681573,PMC12274417,10.1038/s41598-025-10960-9,Peptide dendrimer and hyaluronic acid modified nanovesicles for ocular delivery of timolol maleate and siRNA.,https://pubmed.ncbi.nlm.nih.gov/40681573/,Conclusion; paragraph 65,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Conclusion; paragraph 65.,,,,,,,,TRUE
iv-release-0121,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,304,B,no,299,nusinersen,ASO,,hepatic: hepatotoxicity,2630,37649429,,10.1080/00207454.2023.2251662,"Safety and effectiveness of nusinersen, a treatment for spinal muscular atrophy, in 524 patients: results from an interim analysis of post-marketing surveillance in Japan.",https://pubmed.ncbi.nlm.nih.gov/37649429/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0122,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,185,B,no,203,TLR3; TLR7; TLR8,siRNA,,hepatic: hepatotoxicity,2327,26444021,PMC5058343manuscript-id: NIHMS820714,10.3233/JHD-150163,Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model.,https://pubmed.ncbi.nlm.nih.gov/26444021/,Discussion; paragraph 33,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Discussion; paragraph 33.,,,,,,,,TRUE
iv-release-0123,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,231,B,no,246,lumasiran,ASO/siRNA mixed context,,hepatic: hepatotoxicity,2701,35913563,PMC9925547,10.1007/s00467-022-05684-1,Efficacy and safety of lumasiran for infants and young children with primary hyperoxaluria type 1: 12-month analysis of the phase 3 ILLUMINATE-B trial.,https://pubmed.ncbi.nlm.nih.gov/35913563/,Discussion; paragraph 35,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Discussion; paragraph 35.,,,,,,,,TRUE
iv-release-0124,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,175,B,no,196,Nusinersen,ASO,,hepatic: hepatotoxicity,1643,33899154,PMC8563549,10.1007/s00415-021-10569-8,Nusinersen treatment in adult patients with spinal muscular atrophy: a safety analysis of laboratory parameters.,https://pubmed.ncbi.nlm.nih.gov/33899154/,Discussion; paragraph 36,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Discussion; paragraph 36.,,,,,,,,TRUE
iv-release-0125,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,273,B,no,279,TfR1,ASO,,hepatic: hepatotoxicity,1468,39325927,,10.1002/anie.202415272,Self-Assembled Antibody-Oligonucleotide Conjugates for Targeted Delivery of Complementary Antisense Oligonucleotides.,https://pubmed.ncbi.nlm.nih.gov/39325927/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0126,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,364,B,no,334,MC3; MC3-based,siRNA,,hepatic: hepatotoxicity,1209,41708903,,10.1007/s13346-026-02076-y,Comparative analysis of clinically approved lipid nanoparticles for intranasal siRNA delivery against SARS-CoV-2.,https://pubmed.ncbi.nlm.nih.gov/41708903/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0127,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,398,B,no,206,Inclisiran,siRNA,,hepatic: hepatotoxicity,2301,38057066,,10.1016/j.jacc.2023.10.007,Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials.,https://pubmed.ncbi.nlm.nih.gov/38057066/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0128,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,412,B,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,hepatic: hepatotoxicity,2110,22326642,,10.1016/j.vaccine.2012.01.087,Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adults 18-55 years of age.,https://pubmed.ncbi.nlm.nih.gov/22326642/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0129,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,165,B,no,187,SLN360,siRNA,,hepatic: hepatotoxicity,1486,35737426,PMC9516055,10.1093/toxsci/kfac067,"Preclinical Toxicological Assessment of A Novel siRNA, SLN360, Targeting Elevated Lipoprotein (a) in Cardiovascular Disease.",https://pubmed.ncbi.nlm.nih.gov/35737426/,DISCUSSION; paragraph 52,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=DISCUSSION; paragraph 52.,,,,,,,,TRUE
iv-release-0130,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,378,B,no,346,viltolarsen,ASO,,hepatic: hepatotoxicity,1274,39549635,,10.1016/j.braindev.2024.10.005,Safety and efficacy of viltolarsen treatment in patients with Duchenne muscular dystrophy: A retrospective study with 3-year follow-up.,https://pubmed.ncbi.nlm.nih.gov/39549635/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0131,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,382,B,no,349,PCSK9; NCT05763875; Inclisiran,ASO/siRNA mixed context,,hepatic: hepatotoxicity,2280,40392667,,10.1016/j.jacc.2025.04.049,Safety and Lipid-Lowering Efficacy of Inclisiran Monotherapy in Patients Without ASCVD: The VICTORION-Mono Randomized Clinical Trial.,https://pubmed.ncbi.nlm.nih.gov/40392667/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0132,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,386,B,no,196,Nusinersen,ASO,,hepatic: hepatotoxicity,7632,41337773,,,Real-Time Ultrasound-Guided Intrathecal Delivery of Nusinersen in Adult Patients With Spinal Muscular Atrophy and Complex Spinal Anatomy.,https://pubmed.ncbi.nlm.nih.gov/41337773/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0133,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,251,B,no,264,patisiran; givosiran; vutrisiran,siRNA,,hepatic: hepatotoxicity,1218,41274662,,10.1177/21593337251391029,Class-Specific Adverse Events of Patients Treated with Small Interfering RNA Therapeutics: A Disproportionality Analysis of the United States Food and Drug Administration Adverse Event Reporting System Database Based on the MY FAERS Platform.,https://pubmed.ncbi.nlm.nih.gov/41274662/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0134,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,193,B,no,219,MKK4,siRNA,,hepatic: hepatotoxicity,1152,41970250,PMC13067123,10.1016/j.mtbio.2026.103059,Dual targeted gene delivery strategy mediated by GalNAc-modified lipid nanoparticles enhances liver regeneration through specific knockdown of MKK4.,https://pubmed.ncbi.nlm.nih.gov/41970250/,Discussion; paragraph 52,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Discussion; paragraph 52.,,,,,,,,TRUE
iv-release-0135,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,371,B,no,341,NCT04439539; FUW48; log10IU,siRNA,,hepatic: hepatotoxicity,1775,41193172,,10.1136/gutjnl-2025-336592,Peginterferon alpha-2a add-on to siRNA JNJ-73763989 in untreated patients with HBeAg-positive chronic hepatitis B virus (HBV) infection: the phase 2 REEF-IT study.,https://pubmed.ncbi.nlm.nih.gov/41193172/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0136,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,1403,B,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,chemistry: fluorocarbon/aptamer comodification enhances siRNA delivery,3571,40747059,PMC12308423,10.1021/jacsau.5c00474,Programmable Comodification of DNA Soccer Framework with Fluorocarbon and Aptamer for Efficient siRNA Delivery.,https://pubmed.ncbi.nlm.nih.gov/40747059/,PubMed abstract sentence 4,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract sentence 7: primary toxicity support for toxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0137,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,296,B,no,291,GalNAc3; GalNAc3-conjugated,ASO,,hepatic: hepatotoxicity,1112,38227794,,10.1089/nat.2023.0026,Safety and Tolerability of GalNAc(3)-Conjugated Antisense Drugs Compared to the Same-Sequence 2'-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data.,https://pubmed.ncbi.nlm.nih.gov/38227794/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0138,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,1329,B,no,985,"unspecified siRNA (v1 extraction artefact, pending source re-verification)",siRNA,,hepatic: hepatotoxicity,4516,42173110,,10.1016/S2468-1253(26)00058-0,"The small interfering RNA imdusiran as single and multiple doses in healthy, randomised individuals and non-randomised individuals with chronic hepatitis B (AB-729-001): a phase 1a/b trial.",https://pubmed.ncbi.nlm.nih.gov/42173110/,PubMed abstract,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0139,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,264,B,no,252,nusinersen,ASO/siRNA mixed context,,general safety: safety/tolerability,12078,39690144,,10.1080/14740338.2024.2443796,Adverse events of nusinersen: a real-world drug safety surveillance study based on the FDA adverse event reporting system (FAERS) database.,https://pubmed.ncbi.nlm.nih.gov/39690144/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for safety/tolerability; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0140,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,401,B,no,361,PCSK9; NCT03060577; inclisiran,siRNA,,hepatic: hepatotoxicity,2697,36620965,,10.1016/S2213-8587(22)00353-9,Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial.,https://pubmed.ncbi.nlm.nih.gov/36620965/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0141,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,1410,B,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,chemistry: 5'-vinylphosphonate improves siRNA accumulation/silencing,12652,28591791,PMC5570069,10.1093/nar/gkx507,5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.,https://pubmed.ncbi.nlm.nih.gov/28591791/,PubMed abstract sentence 4,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0142,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,474,B,no,430,ISIS 405879 2'-MOE ASO,ASO,,hematological: thrombocytopenia,2090,37093125,,10.1089/nat.2022.0042,Complement C3d/C4d Deposition on Platelets Correlates with 2'-O-Methoxyethyl Antisense Oligonucleotide-Induced Thrombocytopenia in Monkeys.,https://pubmed.ncbi.nlm.nih.gov/37093125/,PubMed abstract,,accept,machine_precurated_v1,"Verified PubMed abstract: ISIS 405879, a 2'-MOE ASO, induced severe thrombocytopenia in susceptible cynomolgus monkeys with platelet-bound C3d/C4d and antibody-marker changes.",,,,,,,,TRUE
iv-release-0143,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,372,B,no,342,NCT05618379; Nusinersen,ASO/siRNA mixed context,,hepatic: hepatotoxicity,2417,41461996,,10.1007/s12325-025-03475-2,Effectiveness and Safety of Nusinersen Among Adults with 5q-Spinal Muscular Atrophy: A Multicenter Disease Registry in China.,https://pubmed.ncbi.nlm.nih.gov/41461996/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0144,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,365,B,no,335,NCT04014335; RO7434656; sefaxersen,ASO,,hepatic: hepatotoxicity,1308,41443406,,10.1016/j.kint.2025.11.017,A single-arm phase 2 trial of an investigational RNA therapeutic to complement factor B sefaxersen for treatment of IgA nephropathy.,https://pubmed.ncbi.nlm.nih.gov/41443406/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0145,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,363,B,no,93,Inclisiran,ASO/siRNA mixed context,,general safety: safety/tolerability,1201,41860775,,10.2459/JCM.0000000000001852,Inclisiran safety and efficacy in real-world clinical practice: results of a retrospective observational investigation.,https://pubmed.ncbi.nlm.nih.gov/41860775/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for safety/tolerability; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0146,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,355,B,no,186,unspecified antisense oligonucleotide,ASO,,renal: renal safety,2839,21540336,,10.1177/1091581811403505,"Repeat-dose toxicology evaluation in cynomolgus monkeys of AVI-4658, a phosphorodiamidate morpholino oligomer (PMO) drug for the treatment of duchenne muscular dystrophy.",https://pubmed.ncbi.nlm.nih.gov/21540336/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for renal safety; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0147,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,208,B,no,230,Tofersen,ASO,,neurological: neurotoxicity,2347,40017137,PMC12060635,10.1002/mus.28372,Serious Neurologic Adverse Events in Tofersen Clinical Trials for Amyotrophic Lateral Sclerosis.,https://pubmed.ncbi.nlm.nih.gov/40017137/,Discussion; paragraph 30,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for neurotoxicity; location=Discussion; paragraph 30.,,,,,,,,TRUE
iv-release-0148,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,238,B,no,251,revusiran,siRNA,,hepatic: hepatotoxicity,2105,30820542,PMC6468299,10.1093/nar/gkz140,Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.,https://pubmed.ncbi.nlm.nih.gov/30820542/,DISCUSSION; paragraph 57,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=DISCUSSION; paragraph 57.,,,,,,,,TRUE
iv-release-0149,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,376,B,no,345,CORE2-TIMI; NCT05079919; NCT05552326,ASO,,hepatic: hepatotoxicity,7173,41211918,,10.1056/NEJMoa2512761,Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk.,https://pubmed.ncbi.nlm.nih.gov/41211918/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0150,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,362,B,no,333,AUC0-inf; Zerlasiran,siRNA,,hepatic: hepatotoxicity,1182,42108101,,10.5551/jat.66214,"A Phase 1 Study Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Zerlasiran in Japanese Participants.",https://pubmed.ncbi.nlm.nih.gov/42108101/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0151,release_accept,release_accept/toxicity_endpoint/B/no,toxicity,toxicity_endpoint,359,B,no,330,PCSK9; NCT04652726; inclisiran,siRNA,,hepatic: hepatotoxicity,1155,41616799,,10.1016/S2213-8587(25)00351-1,"Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial.",https://pubmed.ncbi.nlm.nih.gov/41616799/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0152,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,54,B,yes,68,PMO-P6 conjugate from PMID 34841414,ASO,DMD,renal: renal safety,4112,34841414,PMC8611673,10.1021/jacsau.1c00327,Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers.,https://pubmed.ncbi.nlm.nih.gov/34841414/,Results > In Vivo Studies; paragraph 30,,accept,machine_precurated_v1,PMC full text checked; Results paragraph reports no kidney biomarker elevation for PMO-P6 up to tested doses.,,,,,,,,TRUE
iv-release-0153,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,17,B,yes,31,scFv-MML@LPCAT1si from PMID 40898177,siRNA,LPCAT1,general safety: systemic safety,3529,40898177,PMC12406594,10.1186/s12896-025-01000-5,Biomimetic nanoparticles coated with ScFv-modified macrophage membranes for siRNA delivery to relieve brain metastases of lung cancer.,https://pubmed.ncbi.nlm.nih.gov/40898177/,Results > In vivo safety access; paragraph 30,,accept,machine_precurated_v1,PMC full text checked; Results section reports H&E organ histology and ALT/AST/creatinine/BUN safety after siRNA nanoparticle dosing.,,,,,,,,TRUE
iv-release-0154,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,574,B,yes,986,"unspecified ASO (v1 extraction artefact, pending source re-verification)",ASO,,hepatic: hepatotoxicity,9180,40574101,PMC12196915,10.3390/pharmaceutics17060789,Intravenous Administration of sRNA Nanoparticles for Treatment of Osteoporosis in Mice.,https://pubmed.ncbi.nlm.nih.gov/40574101/,Abstract; paragraph 1,,accept,machine_precurated_v1,Verified full text evidence at Abstract; paragraph 1: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0155,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,512,B,yes,1066,"elsunersen (recovered B2 from PMID:40263630, curator:CM)",ASO,,hepatic: hepatotoxicity,1013,40263630,PMC12283366,10.1038/s41591-025-03656-0,Antisense oligonucleotide treatment in a preterm infant with early-onset SCN2A developmental and epileptic encephalopathy.,https://pubmed.ncbi.nlm.nih.gov/40263630/,Methods > Patient eligibility; paragraph 16,,accept,machine_precurated_v1,Verified full text evidence at Methods > Patient eligibility; paragraph 16: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0156,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,94,B,yes,112,CD11b-modified-targeting siRNA from PMID 40977834,siRNA,,renal: renal safety,3501,40977834,PMC12446780,10.1016/j.mtbio.2025.102226,CD11b-modified ROS/pH-responsive nanoparticles co-deliver Dioscin and siRNA to improve cardiac repair after myocardial infarction by reducing neutrophil recruitment.,https://pubmed.ncbi.nlm.nih.gov/40977834/,Results > In vivo biosafety assessment; paragraph 50,,accept,machine_precurated_v1,PMC full text checked; verified source supports renal safety evidence.,,,,,,,,TRUE
iv-release-0157,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,678,B,yes,563,Site-specific,ASO,,hepatic: hepatotoxicity,1638,34141070,PMC8201499,10.1021/acsmedchemlett.1c00072,"Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides.",https://pubmed.ncbi.nlm.nih.gov/34141070/,Abstract; paragraph 1,,accept,machine_precurated_v1,Verified full text evidence at Abstract; paragraph 1: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0158,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,136,B,yes,163,Fitusiran,ASO,,hepatic: hepatotoxicity,2538,39642315,PMC11914172,10.1182/bloodadvances.2024013900,"Long-term safety and efficacy of fitusiran prophylaxis, and perioperative management, in people with hemophilia A or B.",https://pubmed.ncbi.nlm.nih.gov/39642315/,Results > Safety; paragraph 20,,accept,machine_precurated_v1,PMC full text checked; verified source supports hepatotoxicity evidence.,,,,,,,,TRUE
iv-release-0159,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,736,B,yes,494,unspecified ASO,ASO,,general toxicity: toxicity,4256,24586944,PMC3931823,10.1371/journal.pone.0089659,In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.,https://pubmed.ncbi.nlm.nih.gov/24586944/,Abstract > Methods; paragraph 2,,accept,machine_precurated_v1,Verified full text evidence at Abstract > Methods; paragraph 2: primary toxicity support for toxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0160,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,47,B,yes,61,CYP3A5 PMO/PSO panel from PMID 33633318,ASO,CYP3A5,renal: renal safety,1471,33633318,PMC7907328,10.1038/s41598-021-84194-w,Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease.,https://pubmed.ncbi.nlm.nih.gov/33633318/,Results; paragraph 14,,accept,machine_precurated_v1,PMC full text checked; Results paragraph evaluates CYP3A5 ASO renal safety markers in a proximal tubule microphysiological system.,,,,,,,,TRUE
iv-release-0161,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,35,B,yes,49,miR-125a-5p agomir from PMID 36632217,miRNA agomir,MIR125A,general safety: cardiac and systemic safety,1960,36632217,PMC9830430,10.7150/thno.73568,Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia/reperfusion injury in mice and swine.,https://pubmed.ncbi.nlm.nih.gov/36632217/,Results > Myocardial I/R swine receiving miR-125a-5p agomir show no alterations in arrhythmic occurrences and serum chemistries; paragraph 23,,accept,machine_precurated_v1,PMC full text checked; Results paragraph reports arrhythmia monitoring and serum chemistry after miR-125a-5p agomir treatment.,,,,,,,,TRUE
iv-release-0162,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,243,B,yes,186,unspecified antisense oligonucleotide,ASO,,hepatic: hepatotoxicity,2329,23952551,PMC3760025,10.1089/nat.2013.0436,Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern.,https://pubmed.ncbi.nlm.nih.gov/23952551/,Abstract; paragraph 1,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Abstract; paragraph 1.,,,,,,,,TRUE
iv-release-0163,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,90,B,yes,108,TLR9-targeted; STAT3; PD1-targeting ASO from PMID 40214214,ASO,,immunotoxicity: immune activation,1843,40214214,PMC12526143,10.1093/neuonc/noaf099,Multimodal glioma immunotherapy combining TLR9-targeted STAT3 antisense oligodeoxynucleotides with PD1 immune checkpoint blockade.,https://pubmed.ncbi.nlm.nih.gov/40214214/,Results > Reduced IFN-I-Related Neurotoxicities after Intracranial Administration of CpG-STAT3dsASO; paragraph 29,,accept,machine_precurated_v1,PMC full text checked; verified source supports immune activation evidence.,,,,,,,,TRUE
iv-release-0164,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,568,B,yes,1070,unspecified siRNA (PMID:40848064),siRNA,,general safety: cell viability/cytotoxicity,8603,40848064,PMC12374930,10.1007/s00262-025-04148-3,"Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermia.",https://pubmed.ncbi.nlm.nih.gov/40848064/,Materials and methods > Cell viability assay; paragraph 25,,accept,machine_precurated_v1,Verified full text evidence at Materials and methods > Cell viability assay; paragraph 25: primary toxicity support for cell viability/cytotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0165,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,177,B,yes,198,Revusiran,siRNA,,hepatic: hepatotoxicity,1430,31821125,PMC6987735,10.1089/nat.2019.0796,"Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis.",https://pubmed.ncbi.nlm.nih.gov/31821125/,Abstract; paragraph 1,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Abstract; paragraph 1.,,,,,,,,TRUE
iv-release-0166,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,1240,B,yes,986,"unspecified ASO (v1 extraction artefact, pending source re-verification)",ASO,,hepatic: hepatotoxicity,1619,35667416,PMC9270256,10.1016/j.jlr.2022.100237,ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy.,https://pubmed.ncbi.nlm.nih.gov/35667416/,Materials and methods > Animal studies > Study 1; paragraph 15,,accept,machine_precurated_v1,Verified full text evidence at Materials and methods > Animal studies > Study 1; paragraph 15: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0167,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,34,B,yes,48,OligoA-11/Skeen-11 phosphorothioate oligonucleotide panel from PMID 37185731,ASO,G6PD,hepatic; renal: hepatic and renal toxicity,1138,37185731,PMC10137061,10.3390/cimb45040207,Inhibitory Effect of Phosphorothioate Oligonucleotide Complementary to G6PD mRNA on Murine Melanoma.,https://pubmed.ncbi.nlm.nih.gov/37185731/,2. Results; paragraph 20,,accept,machine_precurated_v1,PMC full text checked; Results paragraph reports liver and kidney pathology after phosphorothioate oligonucleotide dosing.,,,,,,,,TRUE
iv-release-0168,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,56,B,yes,70,stereocontrolled cEt gapmer ASO panel from PMID 31980820,ASO,MALAT1,general safety: cytotoxicity,1423,31980820,PMC7038945,10.1093/nar/gkaa031,Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.,https://pubmed.ncbi.nlm.nih.gov/31980820/,RESULTS > Biological evaluation of fully Rp and Sp gap modified ASOs; paragraph 18,,accept,machine_precurated_v1,PMC full text checked; Results paragraph evaluates stereochemistry-dependent gapmer toxicity markers.,,,,,,,,TRUE
iv-release-0169,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,442,B,yes,398,ISIS 405879,ASO,,hematological: thrombocytopenia,1131,40101742,PMC12043408manuscript-id: NIHMS2042395,10.1093/jimmun/vkae055,Cellular immune changes during severe antisense oligonucleotide-associated thrombocytopenia in a nonhuman primate model.,https://pubmed.ncbi.nlm.nih.gov/40101742/,Abstract; paragraph 1,,accept,machine_precurated_v1,accepted: verified ASO-associated thrombocytopenia evidence in NHPs; ISIS 405879 treatment was linked to severe platelet-count reduction and immune-cell changes.,,,,,,,,TRUE
iv-release-0170,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,105,B,yes,122,ASO candidate from PMID 33567808,ASO,,hematologic: platelet/bleeding safety,2730,33567808,PMC8804562,10.3324/haematol.2020.260059,"Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates.",https://pubmed.ncbi.nlm.nih.gov/33567808/,Results > 2’MOE ASO (104838 and 501861) and CpG ASO increase platelet P-selectin expression in platelet-rich plasma and whole blood; Figure 1. caption,,accept,machine_precurated_v1,PMC full text checked; verified source supports platelet/bleeding safety evidence.,,,,,,,,TRUE
iv-release-0171,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,634,B,yes,1075,"siIRF1 (recovered B2 from PMID:39629104, curator:CM)",siRNA,,general safety: cell viability/cytotoxicity,13678,39629104,PMC11614587,10.2147/IJN.S487598,T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing.,https://pubmed.ncbi.nlm.nih.gov/39629104/,Abstract > Methods; paragraph 2,,accept,machine_precurated_v1,Verified full text evidence at Abstract > Methods; paragraph 2: primary toxicity support for cell viability/cytotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0172,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,209,B,yes,231,givosiran,siRNA,,hepatic: hepatotoxicity,2503,40312531,PMC12045942,10.1038/s41598-025-99526-3,Efficacy and safety of givosiran in Japanese patients with acute hepatic porphyria: clinical findings from an expanded access study.,https://pubmed.ncbi.nlm.nih.gov/40312531/,Abstract; paragraph 1,,accept,machine_precurated_v1,accepted: full text source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=Abstract; paragraph 1.,,,,,,,,TRUE
iv-release-0173,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,55,B,yes,69,PM1(GT/siMMP-9) hydrogel from PMID 33952251,siRNA,MMP9,general safety: local and systemic safety,4145,33952251,PMC8097905,10.1186/s12951-021-00869-6,Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing.,https://pubmed.ncbi.nlm.nih.gov/33952251/,Results > In vivo biocompatibility of PM1(GT/siMMP-910) hydrogel; paragraph 60,,accept,machine_precurated_v1,PMC full text checked; Results paragraph reports no skin allergy or systemic toxicity for sustained siMMP-9 hydrogel delivery.,,,,,,,,TRUE
iv-release-0174,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,437,B,yes,393,LNP-SNORA49 RNA/SOX9 ASO,ASO/RNA mixed context,SOX9,general safety: organ morphology/body weight/cytokine safety,6668,41565615,PMC12824223,10.1038/s41467-025-66486-1,SNORA49 negatively regulates self-renewal of liver cancer stem cells and hepatocarcinogenesis via suppressing SOX9 transcription.,https://pubmed.ncbi.nlm.nih.gov/41565615/,Results > Lipid nanoparticle delivery of SNORA49 and ASOs against SOX9 exerts synergistic antitumor effect on HCC tumors; paragraph 25,,accept,machine_precurated_v1,"accepted: verified Results side-effect assessment for LNP-delivered SNORA49 RNA/SOX9 ASO treatment; treated mice had normal liver/kidney/spleen morphology, comparable body weight/organ size, and no significant cytokine increase.",,,,,,,,TRUE
iv-release-0175,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,89,B,yes,107,ASO candidate from PMID 40243849,ASO,,renal: renal safety,1262,40243849,PMC11988723,10.3390/ijms26073098,Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model.,https://pubmed.ncbi.nlm.nih.gov/40243849/,2. Results > 2.4. MSTN-ASO Treatment Does Not Affect Kidney Functions; paragraph 15,,accept,machine_precurated_v1,PMC full text checked; verified source supports renal safety evidence.,,,,,,,,TRUE
iv-release-0176,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,418,B,yes,374,AVI-6002/AVI-6003 PMOplus,PMOplus,,general safety: clinical safety and pharmacokinetics,2822,25155593,PMC4249403,10.1128/AAC.03442-14,Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies.,https://pubmed.ncbi.nlm.nih.gov/25155593/,Abstract; paragraph 1,,accept,machine_precurated_v1,accepted: verified single-ascending-dose clinical safety/PK evidence for AVI-6002 and AVI-6003 phosphorodiamidate morpholino oligomer combinations at the checked abstract/full-text location.,,,,,,,,TRUE
iv-release-0177,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,16,B,yes,30,JNJ-3989/JNJ-73763989 GalNAc-siRNA regimen from PMID 40919077,siRNA,HBV,general safety: safety/tolerability,3517,40919077,PMC12409438,10.1016/j.jhepr.2025.101516,Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: The phase II PENGUIN study.,https://pubmed.ncbi.nlm.nih.gov/40919077/,Results > Safety; paragraph 22,,accept,machine_precurated_v1,PMC full text checked; Results safety section reports adverse events during siRNA plus peginterferon clinical treatment.,,,,,,,,TRUE
iv-release-0178,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,19,B,yes,33,EM/siKEAP1@Fe-MOF@HA from PMID 40688667,siRNA,KEAP1,general safety: systemic safety,3590,40688667,PMC12274865,10.1016/j.mtbio.2025.102074,Hyaluronic acid-anchored nanoparticles co-delivering emodin and siRNA confers protection against rheumatoid arthritis via macrophage polarization.,https://pubmed.ncbi.nlm.nih.gov/40688667/,Results > Assessment of biosafety in vivo; paragraph 42,,accept,machine_precurated_v1,PMC full text checked; Results biosafety section reports histology and liver/kidney function tests for siRNA nanoparticles.,,,,,,,,TRUE
iv-release-0179,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,605,B,yes,1073,unspecified siRNA (PMID:39296267),siRNA,,hepatic: hepatotoxicity,3848,39296267,PMC11406681,10.1021/acsptsci.4c00336,Lipopolymer/siRNA Nanoparticles Targeting the Signal Transducer and Activator of Transcription 5A Disrupts Proliferation of Acute Lymphoblastic Leukemia.,https://pubmed.ncbi.nlm.nih.gov/39296267/,Abstract; paragraph 1,,accept,machine_precurated_v1,Verified full text evidence at Abstract; paragraph 1: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0180,release_accept,release_accept/toxicity_endpoint/B/yes,toxicity,toxicity_endpoint,93,B,yes,111,siRNA candidate from PMID 41360814,siRNA,,renal: renal safety,3423,41360814,PMC12804779,10.1038/s41467-025-67183-9,Inflammation-specific DNA origami nanodevice for delivery of siRNAs to treat ulcerative colitis.,https://pubmed.ncbi.nlm.nih.gov/41360814/,Results > Biodistribution of the nanodevice; paragraph 11,,accept,machine_precurated_v1,PMC full text checked; verified source supports renal safety evidence.,,,,,,,,TRUE
iv-release-0181,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,408,C,no,365,antiPF4,ASO,,hepatic: hepatotoxicity,2318,29846725,,10.1093/toxsci/kfy119,"Investigation into the Mechanism(s) That Leads to Platelet Decreases in Cynomolgus Monkeys During Administration of ISIS 104838, a 2'-MOE-Modified Antisense Oligonucleotide.",https://pubmed.ncbi.nlm.nih.gov/29846725/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0182,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,249,C,no,262,RyR2; Cy5-labeled; RyR2-targeting,siRNA,,hepatic: hepatotoxicity,1151,41984094,,10.1007/s00204-026-04370-7,Imaging and safety profiling of inhaled siRNA RyR2 in human respiratory models.,https://pubmed.ncbi.nlm.nih.gov/41984094/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0183,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,315,C,no,185,unspecified siRNA,siRNA,,hepatic: hepatotoxicity,13711,39521158,,10.1016/j.ijpharm.2024.124928,Cysteamine functionalized gold nanoparticles exhibit high efficiency delivery of genetic materials in embryonic stem cells majorly via clathrin mediated endocytosis.,https://pubmed.ncbi.nlm.nih.gov/39521158/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0184,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,615,C,no,1090,"HNP-siHOXB7 (recovered B2 from PMID:39458966, curator:CM)",siRNA,,hepatic: hepatotoxicity,10648,39458966,PMC11509954,10.3390/ph17101325,In Vivo HOXB7 Gene Silencing and Cotreatment with Tamoxifen for Luminal A Breast Cancer Therapy.,https://pubmed.ncbi.nlm.nih.gov/39458966/,5. Conclusions; paragraph 51,,accept,machine_precurated_v1,Verified full text evidence at 5. Conclusions; paragraph 51: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0185,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,291,C,no,287,siG12Ss; siG12S; KRASG12S,siRNA,,hepatic: hepatotoxicity,9951,40073943,,10.1016/j.jconrel.2025.113624,A Mannosylated peptidyl lipid CManDA doped into cytidinyl/cationic lipids efficiently delivers siG12Ss to lung cancer in vivo.,https://pubmed.ncbi.nlm.nih.gov/40073943/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0186,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,622,C,no,493,patisiran,siRNA,,immunotoxicity: immune activation,11357,38532802,PMC10964446,10.1177/17562864241239755,Patisiran exposure in early pregnancy: a case report.,https://pubmed.ncbi.nlm.nih.gov/38532802/,Discussion; paragraph 9,,accept,machine_precurated_v1,Verified full text evidence at Discussion; paragraph 9: primary toxicity support for immune activation in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0187,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,385,C,no,185,unspecified siRNA,siRNA,,hepatic: hepatotoxicity,3747,40010411,,10.1016/j.jconrel.2025.02.067,Surfactant protein B-derived peptides as endosomal escape enhancers for pulmonary delivery of siRNA.,https://pubmed.ncbi.nlm.nih.gov/40010411/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0188,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,447,C,no,403,NLP-exosome complex STAT3 siRNA,siRNA,STAT3,general safety: cell viability/cytotoxicity,9471,40427146,PMC12109797,10.3390/cancers17101648,Exosome Enveloped by Nano Lipid Particle a New Model for Signal Transducer and Activator of Transcription 3 Silencer Ribonucleic Acid Delivery System to a Glioblastoma Mice Model.,https://pubmed.ncbi.nlm.nih.gov/40427146/,3. Results > 3.1. The Use of NLP-EXOSOME COMPLEX Nanoparticles Results in the Production of Reliable and Efficient Formulations for Delivering siRNA; paragraph 29,,accept,machine_precurated_v1,Verified full-text Results: NLP-exosome STAT3-siRNA complex showed in vitro biocompatibility by LDH release assay with no cell damage during transfection; graded C because safety evidence is brief.,,,,,,,,TRUE
iv-release-0189,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,124,C,no,151,siRNA candidate from PMID 41896932,siRNA,,renal: renal safety,5624,41896932,PMC13151111,10.1186/s12951-026-04311-7,Overcoming lysosomal barrier via V-ATPase: an exosome-based co-delivery platform for combined chemo/RNAi therapy against breast cancer.,https://pubmed.ncbi.nlm.nih.gov/41896932/,Result and discussion > In vivo safety assessment; paragraph 61,,accept,machine_precurated_v1,PMC full text checked; verified source supports renal safety evidence.,,,,,,,,TRUE
iv-release-0190,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,627,C,no,472,siRNA-mediated,siRNA,,hepatic: hepatotoxicity,12444,39553720,PMC11566511,10.7717/peerj.18214,Investigation of the efficacy of siRNA-mediated KRAS gene silencing in pancreatic cancer therapy.,https://pubmed.ncbi.nlm.nih.gov/39553720/,RESULTS AND DISCUSSION > Evaluation of the efficacy of gene silencing with in vitro RT-PCR; paragraph 45,,accept,machine_precurated_v1,Verified full text evidence at RESULTS AND DISCUSSION > Evaluation of the efficacy of gene silencing with in vitro RT-PCR; paragraph 45: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0191,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,551,C,no,528,Silica,siRNA,,hepatic: hepatotoxicity,7559,41392621,PMC12754758manuscript-id: NIHMS2132376,10.1021/acsami.5c15253,"Modular Design of Mesoporous Silica Nanoparticles Enables Bioimaging, Dual Chemotherapy, and Combinatorial Gene Silencing in Triple-Negative Breast Cancer.",https://pubmed.ncbi.nlm.nih.gov/41392621/,Results and Discussion > Specific Gene Silencing Studies; paragraph 21,,accept,machine_precurated_v1,Verified full text evidence at Results and Discussion > Specific Gene Silencing Studies; paragraph 21: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0192,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,629,C,no,1091,"cRGD-PEG-siRNA (recovered B2 from PMID:39431993, curator:CM)",siRNA,,hepatic: hepatotoxicity,12453,39431993,PMC11583972,10.1021/acs.bioconjchem.4c00255,A pH-Sensitive cRGD-PEG-siRNA Conjugated Compound Targeting Glioblastoma.,https://pubmed.ncbi.nlm.nih.gov/39431993/,Results and Discussion > Toxicity of cRGD-PEG-siRNA to Renal Tubular Epithelial Cells; paragraph 11,,accept,machine_precurated_v1,Verified full text evidence at Results and Discussion > Toxicity of cRGD-PEG-siRNA to Renal Tubular Epithelial Cells; paragraph 11: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0193,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,11,C,no,25,nebulized siIL-1beta.2 from PMID 41898774,siRNA,IL1B,general safety: cytotoxicity,3211,41898774,PMC13026121,10.3390/ijms27062915,Functional siRNA Delivery via Jet Nebulization: Proof-of-Concept IL-1ß Silencing in Macrophage-like THP-1 Cells.,https://pubmed.ncbi.nlm.nih.gov/41898774/,2. Results > 2.6. Knockdown of Endogenously Expressed IL-1β by Nebulized siRNA; paragraph 27,,accept,machine_precurated_v1,PMC full text checked; Results paragraph reports nebulized siRNA knockdown with minimal cytotoxicity in THP-1 macrophage-like cells.,,,,,,,,TRUE
iv-release-0194,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,413,C,no,186,unspecified antisense oligonucleotide,ASO,,renal: renal safety,2269,22709826,,10.1016/j.tox.2012.06.005,Renal uptake and tolerability of a 2'-O-methoxyethyl modified antisense oligonucleotide (ISIS 113715) in monkey.,https://pubmed.ncbi.nlm.nih.gov/22709826/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for renal safety; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0195,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,1426,C,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,delivery: modified PEI nanoparticle siRNA transfection efficacy,12538,36541426,,10.1002/biot.202200415,Analysis of polymeric nanoparticle properties for siRNA/DNA delivery in a tumor xenograft tissue slice air-liquid interface model.,https://pubmed.ncbi.nlm.nih.gov/36541426/,PubMed title,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0196,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,83,C,no,98,Imetelstat,ASO/siRNA mixed context,,hematologic: platelet/bleeding safety,8005,41135032,PMC12614338manuscript-id: NIHMS2109501,10.1200/JCO-25-01369,US Food and Drug Administration Approval Summary: Imetelstat for Selected Patients With Low- to Intermediate-1 Risk Myelodysplastic Syndromes With Transfusion-Dependent Anemia.,https://pubmed.ncbi.nlm.nih.gov/41135032/,Abstract; paragraph 1,,accept,machine_precurated_v1,PMC full text checked; verified source supports platelet/bleeding safety evidence.,,,,,,,,TRUE
iv-release-0197,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,656,C,no,443,inclisiran,siRNA,,hepatic: hepatotoxicity,14195,37021909,PMC10077952,10.1002/prp2.1080,The N-Acetylgalactosamine-conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low-density lipoprotein cholesterol reductions.,https://pubmed.ncbi.nlm.nih.gov/37021909/,DISCUSSION; paragraph 60,,accept,machine_precurated_v1,Verified full text evidence at DISCUSSION; paragraph 60: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0198,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,1393,C,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,chemistry: seed-region modification reduces off-target binding,1157,41467115,PMC12744844,10.1016/j.omtn.2025.102693,An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA.,https://pubmed.ncbi.nlm.nih.gov/41467115/,PubMed abstract sentence 1,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0199,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,324,C,no,310,CpG55; rH7HA,ASO/siRNA mixed context,,hepatic: hepatotoxicity,12177,37659896,,10.1016/j.vaccine.2023.08.053,Developmental and reproductive safety of Advax-CpG55.2™ adjuvanted COVID-19 and influenza vaccines in mice.,https://pubmed.ncbi.nlm.nih.gov/37659896/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0200,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,118,C,no,145,ASO candidate from PMID 41754970,ASO,,hepatic: hepatotoxicity,1065,41754970,PMC12944301,10.3390/pharmaceutics18020228,Unconventional Lysine-Type Lipid Assemblies Enable Efficient Antisense Oligonucleotide Delivery with Distinct Structural Features.,https://pubmed.ncbi.nlm.nih.gov/41754970/,3. Results and Discussions > 3.3. In Vitro Delivery of Splice-Switch ASO; paragraph 26,,accept,machine_precurated_v1,PMC full text checked; verified source supports hepatotoxicity evidence.,,,,,,,,TRUE
iv-release-0201,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,127,C,no,154,RO7239958,ASO,,neurological: neurotoxicity,1040,41186228,PMC12691668,10.1128/aac.00679-25,"Safety, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide RO7239958 in healthy volunteers and adults with chronic hepatitis B infection.",https://pubmed.ncbi.nlm.nih.gov/41186228/,INTRODUCTION; paragraph 4,,accept,machine_precurated_v1,PMC full text checked; verified source supports neurotoxicity evidence.,,,,,,,,TRUE
iv-release-0202,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,115,C,no,133,ASO candidate from PMID 32530964,ASO,,hepatic: hepatotoxicity,1431,32530964,PMC7292364,10.1371/journal.pone.0232603,Refining LNA safety profile by controlling phosphorothioate stereochemistry.,https://pubmed.ncbi.nlm.nih.gov/32530964/,Conclusion; paragraph 41,,accept,machine_precurated_v1,PMC full text checked; verified source supports hepatotoxicity evidence.,,,,,,,,TRUE
iv-release-0203,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,671,C,no,1093,"HA-SeSe-COOH/siR-93C@PAMAM (recovered B2 from PMID:35156491, curator:CM)",siRNA,,hepatic: hepatotoxicity,4091,35156491,PMC8856077,10.1080/10717544.2022.2032874,Hyaluronic acid-modified redox-sensitive hybrid nanocomplex loading with siRNA for non-small-cell lung carcinoma therapy.,https://pubmed.ncbi.nlm.nih.gov/35156491/,Results and discussion > In vivo anticancer activity and safety evaluation; paragraph 49,,accept,machine_precurated_v1,Verified full text evidence at Results and discussion > In vivo anticancer activity and safety evaluation; paragraph 49: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0204,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,290,C,no,286,miRNA34a; LNA34a; NOTCH1,ASO/siRNA mixed context,,hepatic: hepatotoxicity,9647,40306578,,10.1016/j.jconrel.2025.113791,Gemcitabine and miRNA34a mimic codelivery with magnetic nanoparticles enhanced anti-tumor effect against pancreatic cancer.,https://pubmed.ncbi.nlm.nih.gov/40306578/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0205,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,26,C,no,40,pVEC-ASO panel from PMID 38391508,ASO,,general safety: cytotoxicity,1417,38391508,PMC10885958,10.3390/antibiotics13020122,General and Specific Cytotoxicity of Chimeric Antisense Oligonucleotides in Bacterial Cells and Human Cell Lines.,https://pubmed.ncbi.nlm.nih.gov/38391508/,3. Results > 3.3. Cell Growth Inhibition by Antisense Oligonucleotides; paragraph 21,,accept,machine_precurated_v1,PMC full text checked; Results paragraph reports ASO cytotoxicity testing in non-tumor fibroblasts and human cancer cell lines.,,,,,,,,TRUE
iv-release-0206,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,539,C,no,985,"unspecified siRNA (v1 extraction artefact, pending source re-verification)",siRNA,,general safety: cell viability/cytotoxicity,3596,40679089,PMC12344721,10.1021/acs.biomac.5c00344,Cleavable Cationic Carbosilane Dendrimers with pH-Tunable Charge as siRNA Carriers.,https://pubmed.ncbi.nlm.nih.gov/40679089/,Results and Discussion > Biocompatibility of Cleavable Dendrimers; paragraph 51,,accept,machine_precurated_v1,Verified full text evidence at Results and Discussion > Biocompatibility of Cleavable Dendrimers; paragraph 51: primary toxicity support for cell viability/cytotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0207,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,1415,C,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,delivery: PLGA/GelMA hydrogel siRNA cytoplasmic delivery,3276,41647289,PMC12869795,10.1093/rb/rbaf115,A smart nanocomposite bioactive ink for controlled siRNA delivery in calvarial mesenchymal stromal cells as a minimally invasive treatment for craniosynostosis.,https://pubmed.ncbi.nlm.nih.gov/41647289/,PubMed abstract sentence 4,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0208,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,92,C,no,110,siRNA candidate from PMID 41625362,siRNA,,immunotoxicity: immune activation,3396,41625362,PMC12859616,10.1016/j.mtbio.2025.102267,Tumor-homing exosomes enable targeted delivery of siRNA and isoimperatorin for overcoming BTK inhibitor resistance in DLBCL.,https://pubmed.ncbi.nlm.nih.gov/41625362/,Discussion; paragraph 29,,accept,machine_precurated_v1,PMC full text checked; verified source supports immune activation evidence.,,,,,,,,TRUE
iv-release-0209,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,509,C,no,985,"unspecified siRNA (v1 extraction artefact, pending source re-verification)",siRNA,,hepatic: hepatotoxicity,7065,41334811,PMC12801319,10.1021/acs.biomac.5c01202,Hydrolytically Stable Cationic Bis-MPA Dendrimers as Efficient Transfectants for Glioblastoma Cells and Primary Astrocytes.,https://pubmed.ncbi.nlm.nih.gov/41334811/,Results and Discussion > Cytotoxicity Assessment of Dendrimers; paragraph 43,,accept,machine_precurated_v1,Verified full text evidence at Results and Discussion > Cytotoxicity Assessment of Dendrimers; paragraph 43: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0210,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,140,C,no,167,siRNA candidate from PMID 40433119,siRNA,,renal: renal safety,3666,40433119,PMC12106909,10.2147/IJN.S510514,Lipid-Coated Ag@MnO(2) Core-Shell Nanoparticles for Co-Delivery of Survivin siRNA in Breast Tumor Therapy.,https://pubmed.ncbi.nlm.nih.gov/40433119/,Results and Discussion > Biochemical Parameter Determination; paragraph 50,,accept,machine_precurated_v1,PMC full text checked; verified source supports renal safety evidence.,,,,,,,,TRUE
iv-release-0211,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,1390,C,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,chemistry: chemical-modification off-target reduction,1003,40877521,,10.1007/978-1-0716-4742-4_24,siRMSD: A Structural Parameter to Reduce Sequence-Dependent Off-Target Effects for siRNA Design with Chemical Modifications.,https://pubmed.ncbi.nlm.nih.gov/40877521/,PubMed abstract sentence 7,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0212,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,331,C,no,315,TPPS2a; TPPS2a-,siRNA,,hepatic: hepatotoxicity,4126,34437914,,10.1016/j.jconrel.2021.08.039,TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy.,https://pubmed.ncbi.nlm.nih.gov/34437914/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0213,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,1428,C,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,delivery: pH-responsive NP siRNA-prodrug tumor release,12601,31381852,,10.1021/acs.nanolett.9b01660,Stimuli-Responsive Polymer-Prodrug Hybrid Nanoplatform for Multistage siRNA Delivery and Combination Cancer Therapy.,https://pubmed.ncbi.nlm.nih.gov/31381852/,PubMed abstract sentence 1,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for renal safety in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0214,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,153,C,no,177,Fesomersen,ASO,,hematologic: platelet/bleeding safety,2297,38563414,PMC10985948,10.1111/cts.13784,"Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers.",https://pubmed.ncbi.nlm.nih.gov/38563414/,Abstract; paragraph 1,,accept,machine_precurated_v1,PMC full text checked; verified source supports platelet/bleeding safety evidence.,,,,,,,,TRUE
iv-release-0215,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,288,C,no,185,unspecified siRNA,siRNA,,hepatic: hepatotoxicity,3764,39907973,,10.1007/s13346-025-01800-4,Topical delivery of siRNA to psoriatic skin model using high molecular weight chitosan derivatives: In vitro and in vivo studies.,https://pubmed.ncbi.nlm.nih.gov/39907973/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0216,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,360,C,no,331,DUX4; iDUX4pA,ASO,,hepatic: hepatotoxicity,1176,42198843,,10.1016/j.ymthe.2026.05.010,Lipid nanoparticle delivery of antisense gapmers attenuates pathology in a mouse model of facioscapulohumeral muscular dystrophy.,https://pubmed.ncbi.nlm.nih.gov/42198843/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0217,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,829,C,no,985,"unspecified siRNA (v1 extraction artefact, pending source re-verification)",siRNA,,hepatic: hepatotoxicity,3789,39733890,,10.1016/j.ijbiomac.2024.139219,Shielding siRNA by peptide-based nanofibers: An efficient approach for turning off EGFR gene in breast cancer.,https://pubmed.ncbi.nlm.nih.gov/39733890/,PubMed abstract,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0218,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,30,C,no,44,GxS5/siRNA polyplexes from PMID 39263399,siRNA,tdTomato,general safety: cytotoxicity,3851,39263399,PMC11386170,10.1039/d4na00363b,Efficient siRNA delivery to murine melanoma cells via a novel genipin-based nano-polymer.,https://pubmed.ncbi.nlm.nih.gov/39263399/,Results > Efficacy as siRNA carrier for RNA interference; paragraph 52,,accept,machine_precurated_v1,PMC full text checked; Results paragraph states siRNA polyplex conditions were below the cytotoxicity threshold.,,,,,,,,TRUE
iv-release-0219,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,625,C,no,435,siRNAs,siRNA,,hepatic: hepatotoxicity,11479,38383439,PMC10882889,10.1186/s12943-024-01955-7,The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.,https://pubmed.ncbi.nlm.nih.gov/38383439/,Discussion; paragraph 62,,accept,machine_precurated_v1,Verified full text evidence at Discussion; paragraph 62: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0220,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,129,C,no,156,ASO candidate from PMID 41169576,ASO,,renal: renal safety,1408,41169576,PMC12569656,10.1021/jacsau.5c01005,"Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides.",https://pubmed.ncbi.nlm.nih.gov/41169576/,Results and Discussion > Reduction of Hepatotoxicity by scpBNA Series; paragraph 23,,accept,machine_precurated_v1,PMC full text checked; verified source supports renal safety evidence.,,,,,,,,TRUE
iv-release-0221,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,104,C,no,82,Bepirovirsen,ASO,,hepatic: hepatotoxicity,1460,35971951,PMC9804925,10.1002/cpdd.1154,"Preclinical and Phase 1 Assessment of Antisense Oligonucleotide Bepirovirsen in Hepatitis B Virus-Transgenic Mice and Healthy Human Volunteers: Support for Clinical Dose Selection and Evaluation of Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses.",https://pubmed.ncbi.nlm.nih.gov/35971951/,Discussion; paragraph 52,,accept,machine_precurated_v1,PMC full text checked; verified source supports hepatotoxicity evidence.,,,,,,,,TRUE
iv-release-0222,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,253,C,no,6,RGLS4326,ASO,,hepatic: hepatotoxicity,1472,42132413,,10.1002/jcph.70207,"Pharmacokinetics, Safety, and Tolerability of Anti-miR-17 Oligonucleotide RGLS4326 in Healthy Adult Subjects.",https://pubmed.ncbi.nlm.nih.gov/42132413/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0223,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,410,C,no,366,SGLT2,ASO,,renal: renal safety,2086,22915769,,10.1124/jpet.112.197426,"Pharmacodynamics and subchronic toxicity in mice and monkeys of ISIS 388626, a second-generation antisense oligonucleotide that targets human sodium glucose cotransporter 2.",https://pubmed.ncbi.nlm.nih.gov/22915769/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for renal safety; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0224,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,43,C,no,57,PEG-SSN/siRNA nanoparticle formulation from PMID 36412852,siRNA,EGFR,general safety: cytotoxicity and hemolysis,2305,36412852,PMC9680366,10.3390/jfb13040211,PEGylated Strontium Sulfite Nanoparticles with Spontaneously Formed Surface-Embedded Protein Corona Restrict Off-Target Distribution and Accelerate Breast Tumour-Selective Delivery of siRNA.,https://pubmed.ncbi.nlm.nih.gov/36412852/,3. Results > 3.8. Biocompatibility Assay; paragraph 41,,accept,machine_precurated_v1,PMC full text checked; Results biocompatibility section reports cytotoxicity and hemolysis testing for siRNA nanoparticles.,,,,,,,,TRUE
iv-release-0225,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,271,C,no,277,NS102; ED50,siRNA,,hepatic: hepatotoxicity,1425,41167339,,10.1016/j.jconrel.2025.114366,Incorporation of a polyamine into lipid nanoparticles increases the endosomal release and transfection of nucleic acids without toxicity.,https://pubmed.ncbi.nlm.nih.gov/41167339/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0226,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,31,C,no,45,GBE-PLL/H2O-PLL solid lipid nanoparticle siRNA carriers from PMID 39684010,siRNA,,general safety: apoptosis/cytotoxicity,12064,39684010,PMC11644305,10.3390/polym16233265,Bio-Inspired Polymeric Solid Lipid Nanoparticles for siRNA Delivery: Cytotoxicity and Cellular Uptake In Vitro.,https://pubmed.ncbi.nlm.nih.gov/39684010/,3. Results > 3.6. Caspase 3/7 Activity; paragraph 35,,accept,machine_precurated_v1,PMC full text checked; Results section measures apoptosis/cytotoxicity for polymeric solid-lipid siRNA nanoparticles.,,,,,,,,TRUE
iv-release-0227,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,87,C,no,105,Alox15-targeting siRNA from PMID 41847300,siRNA,,renal: renal safety,1202,41847300,PMC12990253,10.1016/j.bbrep.2026.102534,Dual knockdown of Alox15 and TGF-β1 by lipid nanoparticle-delivered siRNA in bleomycin-induced pulmonary fibrosis.,https://pubmed.ncbi.nlm.nih.gov/41847300/,Results > Assessing in vivo LNP safety: biochemical indicators and vital organ health; paragraph 29,,accept,machine_precurated_v1,PMC full text checked; verified source supports renal safety evidence.,,,,,,,,TRUE
iv-release-0228,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,313,C,no,302,PCSK9; GN3; MC3-LNP,siRNA,,hepatic: hepatotoxicity,11712,37951519,,10.1016/j.actbio.2023.10.038,Engineering a biomimetic system for hepatocyte-specific RNAi treatment of non-alcoholic fatty liver disease.,https://pubmed.ncbi.nlm.nih.gov/37951519/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0229,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,74,C,no,89,siRNA candidate from PMID 40314193,siRNA,,immunotoxicity: immune activation,3700,40314193,PMC12051533,10.1080/13880209.2025.2498169,Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection.,https://pubmed.ncbi.nlm.nih.gov/40314193/,Introduction; paragraph 7,,accept,machine_precurated_v1,PMC full text checked; verified source supports immune activation evidence.,,,,,,,,TRUE
iv-release-0230,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,1429,C,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,delivery: cysteamine gold nanoparticle siRNA delivery,13711,39521158,,10.1016/j.ijpharm.2024.124928,Cysteamine functionalized gold nanoparticles exhibit high efficiency delivery of genetic materials in embryonic stem cells majorly via clathrin mediated endocytosis.,https://pubmed.ncbi.nlm.nih.gov/39521158/,PubMed abstract sentence 7,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for thrombocytopenia in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0231,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,643,C,no,435,siRNAs,siRNA,,hepatic: hepatotoxicity,11811,38077055,PMC10705697,10.21203/rs.3.rs-1297358/v3,The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.,https://pubmed.ncbi.nlm.nih.gov/38077055/,Discussion; paragraph 24,,accept,machine_precurated_v1,Verified full text evidence at Discussion; paragraph 24: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0232,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,1124,C,no,600,the ASO,ASO,,hepatic: hepatotoxicity,10126,39950874,PMC11967816,10.1002/advs.202415169,Nanodot-Inspired Precise Bacterial Gene Suppression in a Smart Hydrogel Bandage for Underwater Wound Healing.,https://pubmed.ncbi.nlm.nih.gov/39950874/,Results and Discussion > Gene Silencing Effects of the ASO/CDs; paragraph 39,,accept,machine_precurated_v1,Verified full text evidence at Results and Discussion > Gene Silencing Effects of the ASO/CDs; paragraph 39: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0233,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,631,C,no,985,"unspecified siRNA (v1 extraction artefact, pending source re-verification)",siRNA,,hepatic: hepatotoxicity,12500,39006767,PMC11240087,10.1039/d4ra01965b,"Carboxymethylcellulose encapsulated fingolimod, siRNA@ZnO hybrid nanocomposite as a new anti-Alzheimer's material.",https://pubmed.ncbi.nlm.nih.gov/39006767/,Results and discussion > Inflammatory inhibition effect of the hybrid nanocomposite; paragraph 40,,accept,machine_precurated_v1,Verified full text evidence at Results and discussion > Inflammatory inhibition effect of the hybrid nanocomposite; paragraph 40: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0234,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,268,C,no,275,Atp5o,ASO,,hepatic: hepatotoxicity,1108,40134366,,10.1089/nat.2024.0047,"Hepatotoxicity Reduction Profiles of Antisense Oligonucleotides Containing Amido-Bridged Nucleic Acid and 2'-O,4'-C-Spirocyclopropylene Bridged Nucleic Acid.",https://pubmed.ncbi.nlm.nih.gov/40134366/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0235,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,1399,C,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,chemistry: GNA isonucleotides improve activity/off-target profile,2309,34648028,PMC8565336,10.1093/nar/gkab916,Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.,https://pubmed.ncbi.nlm.nih.gov/34648028/,PubMed abstract sentence 1,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0236,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,344,C,no,321,KL4,siRNA,,hepatic: hepatotoxicity,12641,29121767,,10.1021/acs.molpharmaceut.7b00725,"From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery.",https://pubmed.ncbi.nlm.nih.gov/29121767/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0237,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,677,C,no,485,siRNA-Loaded,siRNA,,hepatic: hepatotoxicity,1635,34683974,PMC8539450,10.3390/pharmaceutics13101681,Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia.,https://pubmed.ncbi.nlm.nih.gov/34683974/,4. Discussion; paragraph 36,,accept,machine_precurated_v1,Verified full text evidence at 4. Discussion; paragraph 36: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0238,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,350,C,no,325,STAT3,ASO,,hepatic: hepatotoxicity,2331,23692080,,10.1089/nat.2013.0422,Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.,https://pubmed.ncbi.nlm.nih.gov/23692080/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0239,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,1412,C,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,delivery: PEG-(GK)10 ASO polyplex sentinel lymph node delivery,1246,40540297,,10.1021/jacs.5c04234,Structurally Dynamic Polyplexes Enhance Sentinel Lymph Node Delivery of Antisense Oligonucleotides to Inhibit Breast Cancer Recurrence and Metastasis.,https://pubmed.ncbi.nlm.nih.gov/40540297/,PubMed abstract sentence 3,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0240,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,680,C,no,1094,"IONIS-AGT-LRx (recovered B2 from PMID:34222719, curator:CM)",ASO,,hepatic: hepatotoxicity,1992,34222719,PMC8246029,10.1016/j.jacbts.2021.04.004,Antisense Inhibition of Angiotensinogen With IONIS-AGT-L(Rx): Results of Phase 1 and Phase 2 Studies.,https://pubmed.ncbi.nlm.nih.gov/34222719/,Discussion; paragraph 25,,accept,machine_precurated_v1,Verified full text evidence at Discussion; paragraph 25: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0241,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,91,C,no,109,Imetelstat,ASO,,immunotoxicity: immune activation,2111,41390988,PMC12702135,10.1111/cts.70431,"No Effect of Immunogenicity on Pharmacokinetics, Efficacy, and Safety of the Oligonucleotide Telomerase Inhibitor Imetelstat in Lower-Risk Myelodysplastic Syndromes.",https://pubmed.ncbi.nlm.nih.gov/41390988/,Abstract; paragraph 1,,accept,machine_precurated_v1,PMC full text checked; verified source supports immune activation evidence.,,,,,,,,TRUE
iv-release-0242,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,510,C,no,988,"unspecified CpG oligodeoxynucleotide (v1 extraction artefact, pending source re-verification)",CpG oligodeoxynucleotide,,hepatic: hepatotoxicity,7129,41270206,PMC12866702,10.1002/advs.202515052,Spatiotemporally Controlled Tumor Photodynamic/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem.,https://pubmed.ncbi.nlm.nih.gov/41270206/,Results and Discussion > In Vitro Photo‐Controlled Activation and Cytotoxicity of PURH; paragraph 13,,accept,machine_precurated_v1,Verified full text evidence at Results and Discussion > In Vitro Photo‐Controlled Activation and Cytotoxicity of PURH; paragraph 13: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0243,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,119,C,no,146,Vutrisiran,ASO/siRNA mixed context,,neurological: neurotoxicity,1173,41984862,PMC13082648,10.1371/journal.pone.0347417,Assessing the real-world safety of vutrisiran for transthyretin-mediated amyloidosis with polyneuropathy: Based on WHO-VigiAccess and FAERS databases.,https://pubmed.ncbi.nlm.nih.gov/41984862/,Discussion; paragraph 43,,accept,machine_precurated_v1,PMC full text checked; verified source supports neurotoxicity evidence.,,,,,,,,TRUE
iv-release-0244,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,571,C,no,443,inclisiran,siRNA,,hepatic: hepatotoxicity,9021,40645721,PMC12441398,10.1016/j.jaccas.2025.103897,Treatment With Inclisiran During Peritoneal Dialysis.,https://pubmed.ncbi.nlm.nih.gov/40645721/,Discussion; paragraph 11,,accept,machine_precurated_v1,Verified full text evidence at Discussion; paragraph 11: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0245,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,322,C,no,308,BldA50M50; MixA50; MixD50,ASO,,hepatic: hepatotoxicity,2669,37437196,,10.1021/acs.bioconjchem.3c00186,Blended Block Polycation Micelles Enhance Antisense Oligonucleotide Delivery.,https://pubmed.ncbi.nlm.nih.gov/37437196/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0246,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,665,C,no,1092,"PNA4986 (recovered B2 from PMID:35436109, curator:CM)",ASO,,hepatic: hepatotoxicity,1980,35436109,PMC9112330,10.1021/acsinfecdis.2c00089,Antisense Peptide Nucleic Acid-Diaminobutanoic Acid Dendron Conjugates with SbmA-Independent Antimicrobial Activity against Gram-Negative Bacteria.,https://pubmed.ncbi.nlm.nih.gov/35436109/,Results and Discussion > Cell Toxicity of Dendron–PNAs; paragraph 13,,accept,machine_precurated_v1,Verified full text evidence at Results and Discussion > Cell Toxicity of Dendron–PNAs; paragraph 13: primary toxicity support for hepatotoxicity in an oligonucleotide context.,,,,,,,,TRUE
iv-release-0247,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,32,C,no,46,P-E/S Lip PD-L1 siRNA nanovesicle from PMID 39068444,siRNA,CD274,general safety: cytotoxicity,12122,39068444,PMC11282766,10.1186/s12951-024-02700-4,PD-L1 siRNA hitched polyethyleneimine-elastase constituting nanovesicle induces tumor immunogenicity and PD-L1 silencing for synergistic antitumor immunotherapy.,https://pubmed.ncbi.nlm.nih.gov/39068444/,Results > Synthesis and functional validation of P-E/S lip in vitro; paragraph 26,,accept,machine_precurated_v1,PMC full text checked; Results figure caption reports synthesis and cytotoxicity assays for PD-L1 siRNA nanovesicles.,,,,,,,,TRUE
iv-release-0248,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,377,C,no,186,unspecified antisense oligonucleotide,ASO,,hepatic: hepatotoxicity,1127,40967408,,10.1016/j.jconrel.2025.114239,Safety and efficacy of KRAS antisense oligonucleotides and RIG-I agonists delivered by extracellular vesicles for pancreatic cancer peritoneal metastasis treatment.,https://pubmed.ncbi.nlm.nih.gov/40967408/,PubMed abstract,,accept,machine_precurated_v1,accepted: PubMed abstract source supports primary oligonucleotide toxicity evidence for hepatotoxicity; location=PubMed abstract.,,,,,,,,TRUE
iv-release-0249,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,149,C,no,173,PMO candidate from PMID 39119918,PMO,,neurological: neurotoxicity,1135,39119918,PMC11417397,10.1093/nar/gkae686,"Efficacy, biodistribution and safety comparison of chemically modified antisense oligonucleotides in the retina.",https://pubmed.ncbi.nlm.nih.gov/39119918/,Discussion; paragraph 46,,accept,machine_precurated_v1,PMC full text checked; verified source supports neurotoxicity evidence.,,,,,,,,TRUE
iv-release-0250,release_accept,release_accept/toxicity_endpoint/C/no,toxicity,toxicity_endpoint,1430,C,no,208,unspecified oligonucleotide,ASO/siRNA mixed context,,delivery: magnetic hyperthermia siRNA transfection,13877,39052238,,10.1039/d4nr01955e,Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes.,https://pubmed.ncbi.nlm.nih.gov/39052238/,PubMed abstract sentence 2,,accept,machine_precurated_v1,Verified PubMed abstract evidence at PubMed abstract: primary toxicity support for systemic safety/tolerability in an oligonucleotide context.,,,,,,,,TRUE
iv-reject-0001,candidate_reject_control,candidate_reject_control/chemistry/B/ASO,chemistry,curation_candidate,9583,B,no,,,ASO,,"chemistry candidate; matched derived terms: chemical, modification; source title: The chemical evolution of oligonucleotide therapies of clinical utility.",12656,28244990,PMC5517098manuscript-id: NIHMS874289,10.1038/nbt.3765,The chemical evolution of oligonucleotide therapies of clinical utility.,https://pubmed.ncbi.nlm.nih.gov/28244990/,PubMed abstract sentence 4,chemical;modification,reject,curator_rejected,"{""reason"": ""GATE 2 fail: review/background on oligonucleotide chemistry; no observed primary result in the excerpt."", ""grounding_quote"": """", ""source_pmid"": ""28244990"", ""candidate_domain"": ""chemistry""}",,,,,,,,TRUE
iv-reject-0002,candidate_reject_control,candidate_reject_control/chemistry/B/ASO,chemistry,curation_candidate,756,B,no,,,ASO,,chemistry candidate; matched derived terms: lna; source title: Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders.,1487,35057094,PMC8780845,10.3390/pharmaceutics14010200,Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders.,https://pubmed.ncbi.nlm.nih.gov/35057094/,PubMed abstract sentence 4,lna,reject,curator_rejected,"{""reason"": ""GATE 3 fail: passage reports pharmacology/safety of an LNA gapmer, not a chemistry modification-vs-property comparison."", ""grounding_quote"": """", ""source_pmid"": ""35057094"", ""candidate_domain"": ""chemistry""}",,,,,,,,TRUE
iv-reject-0003,candidate_reject_control,candidate_reject_control/chemistry/B/ASO,chemistry,curation_candidate,687,B,no,,,ASO,,chemistry candidate; matched derived terms: modified; source title: Erratum: In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney.,1450,40083647,PMC11905888,10.1016/j.omtn.2025.102497,Erratum: In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney.,https://pubmed.ncbi.nlm.nih.gov/40083647/,PubMed title,modified,reject,curator_rejected,"{""reason"": ""GATE 2 fail: erratum fragment reports omitted urinary-glucose table data only; no chemistry-vs-effect oligo result is judgeable."", ""grounding_quote"": """", ""source_pmid"": ""40083647"", ""candidate_domain"": ""chemistry""}",,,,,,,,TRUE
iv-reject-0004,candidate_reject_control,candidate_reject_control/chemistry/B/ASO/siRNA,chemistry,curation_candidate,1248,B,no,,,ASO/siRNA,,chemistry candidate; matched derived terms: chemical; source title: Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System.,1871,39771501,PMC11728546,10.3390/pharmaceutics16121521,Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System.,https://pubmed.ncbi.nlm.nih.gov/39771501/,PubMed abstract sentence 9,chemical,reject,curator_rejected,"{""reason"": ""GATE 2 fail: passage is review-style discussion of LNP immune responses, not primary chemistry-vs-effect evidence."", ""grounding_quote"": """", ""source_pmid"": ""39771501"", ""candidate_domain"": ""chemistry""}",,,,,,,,TRUE
iv-reject-0005,candidate_reject_control,candidate_reject_control/chemistry/B/ASO/siRNA,chemistry,curation_candidate,7476,B,no,,,ASO/siRNA,,chemistry candidate; matched derived terms: chemical; source title: A colorimetric and electrochemical dual-modal ochratoxin a aptasensor based on branched hybridization chain reaction signal amplification.,9807,40198995,,10.1016/j.bioelechem.2025.108984,A colorimetric and electrochemical dual-modal ochratoxin a aptasensor based on branched hybridization chain reaction signal amplification.,https://pubmed.ncbi.nlm.nih.gov/40198995/,PubMed abstract sentence 7,chemical,reject,curator_rejected,"{""reason"": ""GATE 1 fail: aptamer is used for ochratoxin biosensing, not as a therapeutic oligonucleotide."", ""grounding_quote"": """", ""source_pmid"": ""40198995"", ""candidate_domain"": ""chemistry""}",,,,,,,,TRUE
iv-reject-0006,candidate_reject_control,candidate_reject_control/chemistry/B/ASO/siRNA,chemistry,curation_candidate,2086,B,no,,,ASO/siRNA,,chemistry candidate; matched derived terms: chemical; source title: Improving electrochemical aptasensor sensitivity for Bacillus cereus spore detection in food safety applications.,2427,41289776,,10.1016/j.talanta.2025.129147,Improving electrochemical aptasensor sensitivity for Bacillus cereus spore detection in food safety applications.,https://pubmed.ncbi.nlm.nih.gov/41289776/,PubMed abstract sentence 5,chemical,reject,curator_rejected,"{""reason"": ""GATE 1 fail: aptamer is used for food-safety sensing, not as a therapeutic oligonucleotide."", ""grounding_quote"": """", ""source_pmid"": ""41289776"", ""candidate_domain"": ""chemistry""}",,,,,,,,TRUE
iv-reject-0007,candidate_reject_control,candidate_reject_control/chemistry/B/siRNA,chemistry,curation_candidate,4372,B,no,,,siRNA,,chemistry candidate; matched derived terms: chemical; source title: TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy.,4126,34437914,,10.1016/j.jconrel.2021.08.039,TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy.,https://pubmed.ncbi.nlm.nih.gov/34437914/,PubMed abstract sentence 4,chemical,reject,curator_rejected,"{""reason"": ""GATE 3 fail: excerpt describes a delivery formulation/photochemical internalization system, not a chemistry modification-vs-property result."", ""grounding_quote"": """", ""source_pmid"": ""34437914"", ""candidate_domain"": ""chemistry""}",,,,,,,,TRUE
iv-reject-0008,candidate_reject_control,candidate_reject_control/chemistry/B/siRNA,chemistry,curation_candidate,4163,B,no,,,siRNA,,"chemistry candidate; matched derived terms: conjugate; source title: Silencing of ocular transthyretin, a gene responsible for hereditary transthyretin amyloidosis, by intravitreal injection of an siRNA conjugate into rabbit eyes.",3960,38157582,,10.1016/j.bbrc.2023.149397,"Silencing of ocular transthyretin, a gene responsible for hereditary transthyretin amyloidosis, by intravitreal injection of an siRNA conjugate into rabbit eyes.",https://pubmed.ncbi.nlm.nih.gov/38157582/,PubMed abstract sentence 3,conjugate,reject,curator_rejected,"{""reason"": ""GATE 3 fail: excerpt reports efficacy/safety of a TTR siRNA conjugate injection, not a chemistry modification-vs-property comparison."", ""grounding_quote"": """", ""source_pmid"": ""38157582"", ""candidate_domain"": ""chemistry""}",,,,,,,,TRUE
iv-reject-0009,candidate_reject_control,candidate_reject_control/chemistry/B/siRNA,chemistry,curation_candidate,185,B,no,,,siRNA,,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.",1106,37871778,,10.1016/j.xphs.2023.10.026,Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.,https://pubmed.ncbi.nlm.nih.gov/37871778/,PubMed abstract sentence 1,galnac;lna;conjugate,reject,curator_rejected,"{""reason"": ""GATE 3 fail: passage describes PK-PD modeling of GalNAc-siRNA disposition/pharmacology, not an observed chemistry modification-vs-property comparison."", ""grounding_quote"": """", ""source_pmid"": ""37871778"", ""candidate_domain"": ""chemistry""}",,,,,,,,TRUE
iv-reject-0010,candidate_reject_control,candidate_reject_control/delivery/C/ASO,delivery,curation_candidate,4338,C,no,,,ASO,,delivery candidate; matched derived terms: delivery; source title: Functionalizing Fibrin Hydrogels with Thermally Responsive Oligonucleotide Tethers for On-Demand Delivery.,4095,35049734,PMC8773154,10.3390/bioengineering9010025,Functionalizing Fibrin Hydrogels with Thermally Responsive Oligonucleotide Tethers for On-Demand Delivery.,https://pubmed.ncbi.nlm.nih.gov/35049734/,PubMed abstract sentence 3,delivery,reject,curator_rejected,"{""reason"": ""GATE 2 fail: scaffold/tether design passage lacks a measured therapeutic oligo delivery effect."", ""grounding_quote"": """", ""source_pmid"": ""35049734"", ""candidate_domain"": ""delivery""}",,,,,,,,TRUE
iv-reject-0011,candidate_reject_control,candidate_reject_control/delivery/C/ASO,delivery,curation_candidate,1143,C,no,,,ASO,,"delivery candidate from queue only; source title: Antibody-oligonucleotide conjugates for spatial proteomics: principles, applications, and challenges.",1790,41311216,PMC13191458,10.3724/abbs.2025212,"Antibody-oligonucleotide conjugates for spatial proteomics: principles, applications, and challenges.",https://pubmed.ncbi.nlm.nih.gov/41311216/,source title,,reject,curator_rejected,"{""reason"": ""GATE 1 fail: antibody-oligonucleotide conjugates are spatial-proteomics detection reagents, not therapeutic delivery products."", ""grounding_quote"": """", ""source_pmid"": ""41311216"", ""candidate_domain"": ""delivery""}",,,,,,,,TRUE
iv-reject-0012,candidate_reject_control,candidate_reject_control/delivery/C/ASO,delivery,curation_candidate,6630,C,no,,,ASO,,delivery candidate; matched derived terms: delivery; source title: Ultrasound-Enhanced Delivery of Salvianolic Acid F Targets CXCL5 to Suppress Lung Cancer Progression: Insights from In Vitro PC9 and H1299 Models.,8412,40928959,,10.1177/10849785251367313,Ultrasound-Enhanced Delivery of Salvianolic Acid F Targets CXCL5 to Suppress Lung Cancer Progression: Insights from In Vitro PC9 and H1299 Models.,https://pubmed.ncbi.nlm.nih.gov/40928959/,PubMed abstract sentence 13,delivery,reject,curator_rejected,"{""reason"": ""GATE 1 fail: salvianolic acid F/ultrasound study is small-molecule delivery with no therapeutic oligo."", ""grounding_quote"": """", ""source_pmid"": ""40928959"", ""candidate_domain"": ""delivery""}",,,,,,,,TRUE
iv-reject-0013,candidate_reject_control,candidate_reject_control/delivery/C/ASO/siRNA,delivery,curation_candidate,7786,C,no,,,ASO/siRNA,,delivery candidate; matched derived terms: delivery; source title: Precision Oncology: Advances in Drug Delivery and Imaging.,10310,39757607,,10.2174/0126673878332787241210102302,Precision Oncology: Advances in Drug Delivery and Imaging.,https://pubmed.ncbi.nlm.nih.gov/39757607/,PubMed abstract sentence 3,delivery,reject,curator_rejected,"{""reason"": ""GATE 1 fail: generic smart drug delivery/imaging overview has no therapeutic oligonucleotide primary result."", ""grounding_quote"": """", ""source_pmid"": ""39757607"", ""candidate_domain"": ""delivery""}",,,,,,,,TRUE
iv-reject-0014,candidate_reject_control,candidate_reject_control/delivery/C/ASO/siRNA,delivery,curation_candidate,6246,C,no,,,ASO/siRNA,,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Chemical strategies for brain delivery of genomic therapy.",7715,41291238,PMC12831201manuscript-id: NIHMS2139102,10.1038/s41570-025-00770-y,Chemical strategies for brain delivery of genomic therapy.,https://pubmed.ncbi.nlm.nih.gov/41291238/,PubMed abstract sentence 3,delivery;nanoparticle,reject,curator_rejected,"{""reason"": ""GATE 2 fail: review of chemical brain-delivery strategies; no primary result in the excerpt."", ""grounding_quote"": """", ""source_pmid"": ""41291238"", ""candidate_domain"": ""delivery""}",,,,,,,,TRUE
iv-reject-0015,candidate_reject_control,candidate_reject_control/delivery/C/ASO/siRNA,delivery,curation_candidate,4655,C,no,,,ASO/siRNA,,delivery candidate from queue only; source title: Targeted Metabolomics Uncovers NorCA's Role as a Potent Immunomodulator in Acute Pancreatitis by Promoting Macrophage Reprogramming and Efferocytosis.,4407,42196402,PMC13207563,10.3390/ijms27104421,Targeted Metabolomics Uncovers NorCA's Role as a Potent Immunomodulator in Acute Pancreatitis by Promoting Macrophage Reprogramming and Efferocytosis.,https://pubmed.ncbi.nlm.nih.gov/42196402/,source title,,reject,curator_rejected,"{""reason"": ""GATE 1 fail: NorCA is a bile-acid small molecule; no therapeutic oligonucleotide agent is present."", ""grounding_quote"": """", ""source_pmid"": ""42196402"", ""candidate_domain"": ""delivery""}",,,,,,,,TRUE
iv-reject-0016,candidate_reject_control,candidate_reject_control/delivery/C/siRNA,delivery,curation_candidate,585,C,no,,,siRNA,,delivery candidate; matched derived terms: delivery; source title: Overcoming Chemotherapy Resistance in Triple-Negative Breast Cancer with Nanocarrier-Delivered siRNA Therapeutics.,1389,41899235,PMC13027210,10.3390/jcm15062311,Overcoming Chemotherapy Resistance in Triple-Negative Breast Cancer with Nanocarrier-Delivered siRNA Therapeutics.,https://pubmed.ncbi.nlm.nih.gov/41899235/,PubMed abstract sentence 4,delivery,reject,curator_rejected,"{""reason"": ""GATE 2 fail: narrative review of TNBC nanocarriers; no primary delivery result in the excerpt."", ""grounding_quote"": """", ""source_pmid"": ""41899235"", ""candidate_domain"": ""delivery""}",,,,,,,,TRUE
iv-reject-0017,candidate_reject_control,candidate_reject_control/delivery/C/siRNA,delivery,curation_candidate,9349,C,no,,,siRNA,,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Delivery of siRNAs Against Selective Ion Channels and Transporter Genes Using Hyaluronic Acid-coupled Carbonate Apatite Nanoparticles Synergistically Inhibits Growth and Survival of Breast Cancer Cells.",12487,39099788,PMC11297548,10.2147/IJN.S440419,Delivery of siRNAs Against Selective Ion Channels and Transporter Genes Using Hyaluronic Acid-coupled Carbonate Apatite Nanoparticles Synergistically Inhibits Growth and Survival of Breast Cancer Cells.,https://pubmed.ncbi.nlm.nih.gov/39099788/,PubMed title,delivery;nanoparticle,reject,curator_rejected,"{""reason"": ""GATE 2 fail: background/methods for nanoparticle siRNA delivery; no observed result in the excerpt."", ""grounding_quote"": """", ""source_pmid"": ""39099788"", ""candidate_domain"": ""delivery""}",,,,,,,,TRUE
iv-reject-0018,candidate_reject_control,candidate_reject_control/delivery/C/siRNA,delivery,curation_candidate,137,C,no,,,siRNA,,"delivery candidate; matched derived terms: galnac, conjugated; source title: Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.",1083,41012491,PMC12472881,10.3390/pharmaceutics17091154,Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.,https://pubmed.ncbi.nlm.nih.gov/41012491/,PubMed abstract sentence 1,galnac;conjugated,reject,curator_rejected,"{""reason"": ""GATE 2 fail: background/PBPK setup on siRNA properties; no measured delivery result is reported in the excerpt."", ""grounding_quote"": """", ""source_pmid"": ""41012491"", ""candidate_domain"": ""delivery""}",,,,,,,,TRUE
iv-reject-0019,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,15797,B,no,,,ASO,,offtarget candidate; matched derived terms: hybridization; source title: Mesoporous Polydopamine-Encapsulated Fluorescent Nanodiamonds: A Versatile Platform for Biomedical Applications.,14090,37341540,PMC10361080,10.1021/acsami.3c05443,Mesoporous Polydopamine-Encapsulated Fluorescent Nanodiamonds: A Versatile Platform for Biomedical Applications.,https://pubmed.ncbi.nlm.nih.gov/37341540/,PubMed abstract sentence 7,hybridization,reject,curator_rejected,reject reason: off-target mention is not supported by primary analysis,,,,,,,,TRUE
iv-reject-0020,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,40059,B,no,,,ASO,,"full-text off-target candidate; title/source terms=aso; source title: ASO Author Reflections: ICG Fluorescent-Guided Surgery for Sentinel Lymph Node Biopsy Used as a Single Tracer Shown Sensitivity, Safety, and Efficacy in Early Breast Cancer Surgery.",2558,39313728,PMC11549143,10.1245/s10434-024-16266-w,"ASO Author Reflections: ICG Fluorescent-Guided Surgery for Sentinel Lymph Node Biopsy Used as a Single Tracer Shown Sensitivity, Safety, and Efficacy in Early Breast Cancer Surgery.",https://pubmed.ncbi.nlm.nih.gov/39313728/,PMC full text high-precision preselection,aso,reject,curator_rejected,"{""reason"": ""GATE 1 fail: ASO is a journal/article-series acronym in a sentinel lymph node surgery reflection, not antisense oligonucleotide evidence."", ""grounding_quote"": """", ""source_pmid"": ""39313728"", ""candidate_domain"": ""offtarget""}",,,,,,,,TRUE
iv-reject-0021,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,34534,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=mismatch; source title: Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements.,33449,15781865,PMC555698,10.1073/pnas.0407069102,Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements.,https://pubmed.ncbi.nlm.nih.gov/15781865/,PubMed title,mismatch,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0022,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,39025,B,no,,,ASO,,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine.",1110,38978695,PMC11229412,10.1016/j.omtn.2024.102161,"Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine.",https://pubmed.ncbi.nlm.nih.gov/38978695/,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,reject,curator_rejected,reject reason: anchor text lacks specific off-target evidence,,,,,,,,TRUE
iv-reject-0023,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,31559,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=specificity; source title: RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers.,30474,21831278,PMC3224242,10.1186/1472-6750-11-80,RNase H-dependent PCR (rhPCR): improved specificity and single nucleotide polymorphism detection using blocked cleavable primers.,https://pubmed.ncbi.nlm.nih.gov/21831278/,PubMed title,specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0024,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,13416,B,no,,,ASO,,offtarget candidate; matched derived terms: transcriptome; source title: Single-cell mRNA analysis and surface marker expression profiling of circulating immune cells in humans with alpha-gal syndrome.,8073,41098729,PMC12518106,10.3389/fimmu.2025.1629310,Single-cell mRNA analysis and surface marker expression profiling of circulating immune cells in humans with alpha-gal syndrome.,https://pubmed.ncbi.nlm.nih.gov/41098729/,PubMed abstract sentence 9,transcriptome,reject,curator_rejected,"reject reason: mRNA-only source, not ASO/siRNA/oligonucleotide safety or off-target evidence",,,,,,,,TRUE
iv-reject-0025,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,35479,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: Y-SNP typing of U.S. African American and Caucasian samples using allele-specific hybridization and primer extension.,34394,15317186,,,Y-SNP typing of U.S. African American and Caucasian samples using allele-specific hybridization and primer extension.,https://pubmed.ncbi.nlm.nih.gov/15317186/,PubMed title,hybridization,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0026,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,31532,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors.,30447,16418278,PMC1347966,10.1073/pnas.0504146103,Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors.,https://pubmed.ncbi.nlm.nih.gov/16418278/,PubMed title,hybridization,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0027,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,30404,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: Analysis of in Situ LNA and DNA Hybridization Events on Microspheres.,29319,28233983,,10.1021/acs.biomac.6b01373,Analysis of in Situ LNA and DNA Hybridization Events on Microspheres.,https://pubmed.ncbi.nlm.nih.gov/28233983/,PubMed title,hybridization,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0028,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,30300,B,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: In situ hybridization for rRNA sequences in anatomic pathology specimens, applications for fungal pathogen detection: a review.",29215,23574773,,10.1097/PAP.0b013e31828d187d,"In situ hybridization for rRNA sequences in anatomic pathology specimens, applications for fungal pathogen detection: a review.",https://pubmed.ncbi.nlm.nih.gov/23574773/,PubMed title,hybridization,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0029,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,33921,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing.,32836,26121314,,10.1038/labinvest.2015.83,Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing.,https://pubmed.ncbi.nlm.nih.gov/26121314/,PubMed title,hybridization,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0030,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,29917,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=transcriptome; source title: Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure.,28832,30521666,,10.1167/iovs.18-23962,Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure.,https://pubmed.ncbi.nlm.nih.gov/30521666/,PubMed title,transcriptome,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0031,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,32467,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: Post-injection hybridization of complementary DNA strands on capillary electrophoresis platforms: a novel solution for dsDNA artifacts.,31382,19083835,,10.1016/j.fsigen.2008.03.005,Post-injection hybridization of complementary DNA strands on capillary electrophoresis platforms: a novel solution for dsDNA artifacts.,https://pubmed.ncbi.nlm.nih.gov/19083835/,PubMed title,hybridization,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0032,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,30067,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=microarray; source title: Genome-wide oligonucleotide microarray analysis of gene-expression profiles of Taiwanese patients with anaplastic astrocytoma and glioblastoma multiforme.,28982,18812569,,10.1177/1087057108323908,Genome-wide oligonucleotide microarray analysis of gene-expression profiles of Taiwanese patients with anaplastic astrocytoma and glioblastoma multiforme.,https://pubmed.ncbi.nlm.nih.gov/18812569/,PubMed title,microarray,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0033,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,38525,B,no,,,ASO,,"full-text off-target candidate; title/source terms=silencing, antisense; source title: A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer.",12346,41190324,PMC12582551,10.3389/fgene.2025.1552009,A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer.,https://pubmed.ncbi.nlm.nih.gov/41190324/,PMC full text high-precision preselection,silencing;antisense,reject,curator_rejected,reject reason: anchor text lacks specific off-target evidence,,,,,,,,TRUE
iv-reject-0034,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,33213,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: Neuroanatomical tracing combined with in situ hybridization: analysis of gene expression patterns within brain circuits of interest.,32128,19961877,,10.1016/j.jneumeth.2009.11.021,Neuroanatomical tracing combined with in situ hybridization: analysis of gene expression patterns within brain circuits of interest.,https://pubmed.ncbi.nlm.nih.gov/19961877/,PubMed title,hybridization,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0035,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,37290,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=mismatch; source title: Self-assembled nucleic acid nanoparticles capable of controlled disassembly in response to a single nucleotide mismatch.,36205,20527811,,10.1021/bm100368d,Self-assembled nucleic acid nanoparticles capable of controlled disassembly in response to a single nucleotide mismatch.,https://pubmed.ncbi.nlm.nih.gov/20527811/,PubMed title,mismatch,reject,curator_rejected,"reject reason: no explicit molecule, target, or cohort for verified release evidence",,,,,,,,TRUE
iv-reject-0036,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,32758,B,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: Sequenced RAPD markers to detect hybridization in the barbary partridge (Alectoris barbara, Phasianidae).",31673,21429120,,10.1111/j.1755-0998.2010.02880.x,"Sequenced RAPD markers to detect hybridization in the barbary partridge (Alectoris barbara, Phasianidae).",https://pubmed.ncbi.nlm.nih.gov/21429120/,PubMed title,hybridization,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0037,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,34116,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: A new class of homogeneous nucleic acid probes based on specific displacement hybridization.,33031,11788731,PMC99844,10.1093/nar/30.2.e5,A new class of homogeneous nucleic acid probes based on specific displacement hybridization.,https://pubmed.ncbi.nlm.nih.gov/11788731/,PubMed title,hybridization,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0038,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,37374,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: Demonstration of human telomerase reverse transcriptase in human colorectal carcinomas by in situ hybridization.,36289,11743637,,,Demonstration of human telomerase reverse transcriptase in human colorectal carcinomas by in situ hybridization.,https://pubmed.ncbi.nlm.nih.gov/11743637/,PubMed title,hybridization,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0039,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,29774,B,no,,,ASO,,offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=hybridization; source title: Purification of DNA oligonucleotides to improve hybridization chain reaction performance.,28689,37059331,,10.1016/j.nbt.2023.04.004,Purification of DNA oligonucleotides to improve hybridization chain reaction performance.,https://pubmed.ncbi.nlm.nih.gov/37059331/,PubMed title,hybridization,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0040,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,38970,B,no,,,ASO,,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Delivery of Antisense Oligonucleotides Using the Nano-Cell Vesicle Technology System (nCVTs) for Targeted Cancer Therapy.",1215,41399312,PMC12877987,10.1002/smll.202509094,Delivery of Antisense Oligonucleotides Using the Nano-Cell Vesicle Technology System (nCVTs) for Targeted Cancer Therapy.,https://pubmed.ncbi.nlm.nih.gov/41399312/,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,reject,curator_rejected,"{""reason"": ""GATE 3 fail: passage reports ASO delivery and antitumor efficacy with nCVTs, not an unintended off-target result."", ""grounding_quote"": """", ""source_pmid"": ""41399312"", ""candidate_domain"": ""offtarget""}",,,,,,,,TRUE
iv-reject-0041,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,39024,B,no,,,ASO,,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Structure-activity relationship study of mesyl and busyl phosphoramidate antisense oligonucleotides for unaided and PSMA-mediated uptake into prostate cancer cells.",1103,38501046,PMC10944894,10.3389/fchem.2024.1342178,Structure-activity relationship study of mesyl and busyl phosphoramidate antisense oligonucleotides for unaided and PSMA-mediated uptake into prostate cancer cells.,https://pubmed.ncbi.nlm.nih.gov/38501046/,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,reject,curator_rejected,reject reason: anchor text lacks specific off-target evidence,,,,,,,,TRUE
iv-reject-0042,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,416,B,no,,,ASO,,offtarget candidate; matched derived terms: hybridization; source title: Quantitative Determination of Click-Reactive Antisense Oligonucleotide and Its Reactivity in Rat Brains by Hybridization LC-MS/MS to Support Pretargeted PET Imaging.,1250,40464260,PMC12177869,10.1021/acs.analchem.5c00644,Quantitative Determination of Click-Reactive Antisense Oligonucleotide and Its Reactivity in Rat Brains by Hybridization LC-MS/MS to Support Pretargeted PET Imaging.,https://pubmed.ncbi.nlm.nih.gov/40464260/,PubMed abstract sentence 8,hybridization,reject,curator_rejected,"reject reason: imaging/theranostic delivery study, not primary safety/off-target evidence",,,,,,,,TRUE
iv-reject-0043,candidate_reject_control,candidate_reject_control/offtarget/B/ASO,offtarget,curation_candidate,14313,B,no,,,ASO,,offtarget candidate; matched derived terms: transcriptome; source title: Combined genomics and proteomics unveils elusive variants and vast aetiologic heterogeneity in dystonia.,10139,39937650,PMC12316014,10.1093/brain/awaf059,Combined genomics and proteomics unveils elusive variants and vast aetiologic heterogeneity in dystonia.,https://pubmed.ncbi.nlm.nih.gov/39937650/,PubMed abstract sentence 12,transcriptome,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0044,candidate_reject_control,candidate_reject_control/offtarget/B/ASO/siRNA,offtarget,curation_candidate,5169,B,no,,,ASO/siRNA,,offtarget candidate; matched derived terms: silencing; source title: piRNA: Molecular Mechanisms from Germline Silencing to Somatic Regulation and Roles in Disease.,5610,41898544,PMC13026993,10.3390/ijms27062685,piRNA: Molecular Mechanisms from Germline Silencing to Somatic Regulation and Roles in Disease.,https://pubmed.ncbi.nlm.nih.gov/41898544/,PubMed title,silencing,reject,curator_rejected,"reject reason: review or systematic review, not primary evidence",,,,,,,,TRUE
iv-reject-0045,candidate_reject_control,candidate_reject_control/offtarget/B/ASO/siRNA,offtarget,curation_candidate,12136,B,no,,,ASO/siRNA,,offtarget candidate; matched derived terms: silencing; source title: Overexpression and knockdown of 5-lipoxygenase regulates the migration and invasion of colorectal cancer cells.,5128,42027647,PMC13101042,10.3892/ol.2026.15575,Overexpression and knockdown of 5-lipoxygenase regulates the migration and invasion of colorectal cancer cells.,https://pubmed.ncbi.nlm.nih.gov/42027647/,PubMed abstract sentence 3,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0046,candidate_reject_control,candidate_reject_control/offtarget/B/ASO/siRNA,offtarget,curation_candidate,11147,B,no,,,ASO/siRNA,,offtarget candidate; matched derived terms: off-target; source title: A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery.,3185,42050330,,10.1038/s41587-026-03109-0,A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery.,https://pubmed.ncbi.nlm.nih.gov/42050330/,PubMed abstract sentence 1,off-target,reject,curator_rejected,"reject reason: mRNA-only source, not ASO/siRNA/oligonucleotide safety or off-target evidence",,,,,,,,TRUE
iv-reject-0047,candidate_reject_control,candidate_reject_control/offtarget/B/ASO/siRNA,offtarget,curation_candidate,12304,B,no,,,ASO/siRNA,,"offtarget candidate; matched derived terms: silencing; source title: AGO2, RDR2, and HEN1 comprise a non-canonical DCL4-mediated antiviral pathway independent of DRB4.",5495,41926706,,10.1093/plphys/kiag175,"AGO2, RDR2, and HEN1 comprise a non-canonical DCL4-mediated antiviral pathway independent of DRB4.",https://pubmed.ncbi.nlm.nih.gov/41926706/,PubMed abstract sentence 7,silencing,reject,curator_rejected,reject reason: no oligonucleotide modality linked to off-target evidence,,,,,,,,TRUE
iv-reject-0048,candidate_reject_control,candidate_reject_control/offtarget/B/ASO/siRNA,offtarget,curation_candidate,2945,B,no,,,ASO/siRNA,,offtarget candidate; matched derived terms: seed; source title: Interference of Arabidopsis N-Acetylglucosamine-1-P Uridylyltransferase Expression Impairs Protein N-Glycosylation and Induces ABA-Mediated Salt Sensitivity During Seed Germination and Early Seedling Development.,3082,35747876,PMC9210984,10.3389/fpls.2022.903272,Interference of Arabidopsis N-Acetylglucosamine-1-P Uridylyltransferase Expression Impairs Protein N-Glycosylation and Induces ABA-Mediated Salt Sensitivity During Seed Germination and Early Seedling Development.,https://pubmed.ncbi.nlm.nih.gov/35747876/,PubMed abstract sentence 6,seed,reject,curator_rejected,reject reason: out-of-scope modality/model; not therapeutic ASO/siRNA/oligonucleotide safety or off-target evidence,,,,,,,,TRUE
iv-reject-0049,candidate_reject_control,candidate_reject_control/offtarget/B/ASO/siRNA,offtarget,curation_candidate,15416,B,no,,,ASO/siRNA,,offtarget candidate; matched derived terms: silencing; source title: MZT2B promotes malignant phenotypes in NSCLC cells by enhancing mitochondrial function and COX5B expression.,12953,41213905,PMC12603160,10.1038/s41419-025-08182-y,MZT2B promotes malignant phenotypes in NSCLC cells by enhancing mitochondrial function and COX5B expression.,https://pubmed.ncbi.nlm.nih.gov/41213905/,PubMed abstract sentence 7,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0050,candidate_reject_control,candidate_reject_control/offtarget/B/ASO/siRNA,offtarget,curation_candidate,13421,B,no,,,ASO/siRNA,,"offtarget candidate; matched derived terms: hybridization; source title: Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish.",8079,41090799,PMC12523338,10.3390/cells14191572,"Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish.",https://pubmed.ncbi.nlm.nih.gov/41090799/,PubMed abstract sentence 5,hybridization,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0051,candidate_reject_control,candidate_reject_control/offtarget/B/ASO/siRNA mixed context,offtarget,curation_candidate,39483,B,no,,,ASO/siRNA mixed context,,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Gene knockdown by morpholino-modified oligonucleotides in the zebrafish (Danio rerio) model: applications for developmental toxicology.",2333,22669659,PMC4218736manuscript-id: NIHMS495918,10.1007/978-1-61779-867-2_5,Gene knockdown by morpholino-modified oligonucleotides in the zebrafish (Danio rerio) model: applications for developmental toxicology.,https://pubmed.ncbi.nlm.nih.gov/22669659/,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,reject,curator_rejected,"{""reason"": ""GATE 1 fail: morpholino oligos are used as zebrafish research knockdown tools for developmental toxicology, not as therapeutic oligonucleotides under off-target characterization."", ""grounding_quote"": """", ""source_pmid"": ""22669659"", ""candidate_domain"": ""offtarget""}",,,,,,,,TRUE
iv-reject-0052,candidate_reject_control,candidate_reject_control/offtarget/B/ASO/siRNA mixed context,offtarget,curation_candidate,40456,B,no,,,ASO/siRNA mixed context,,full-text off-target candidate; title/source terms=oligonucleotide; source title: Highly multiplexed tissue imaging using repeated oligonucleotide exchange reaction.,29704,33548142,PMC8251877,10.1002/eji.202048891,Highly multiplexed tissue imaging using repeated oligonucleotide exchange reaction.,https://pubmed.ncbi.nlm.nih.gov/33548142/,PMC full text high-precision preselection,oligonucleotide,reject,curator_rejected,reject reason: anchor text lacks specific off-target evidence,,,,,,,,TRUE
iv-reject-0053,candidate_reject_control,candidate_reject_control/offtarget/B/ASO/siRNA mixed context,offtarget,curation_candidate,39176,B,no,,,ASO/siRNA mixed context,,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: HIV-1 derived oligonucleotides induce a type I IFN/STING dependent immune suppression reversible by targeting IFNARI.",3310,41529066,PMC12826489,10.1371/journal.ppat.1013868,HIV-1 derived oligonucleotides induce a type I IFN/STING dependent immune suppression reversible by targeting IFNARI.,https://pubmed.ncbi.nlm.nih.gov/41529066/,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,reject,curator_rejected,reject reason: full-text anchor is background/discussion rather than primary evidence,,,,,,,,TRUE
iv-reject-0054,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,16511,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=specificity; source title: A protocol for designing siRNAs with high functionality and specificity.,15426,17853862,,10.1038/nprot.2007.278,A protocol for designing siRNAs with high functionality and specificity.,https://pubmed.ncbi.nlm.nih.gov/17853862/,PubMed title,specificity,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0055,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,15393,B,no,,,siRNA,,"offtarget candidate; matched derived terms: silencing; source title: Targeting vacuolar ATPase in tobacco whitefly, Bemisia tabaci (Gennadius): Insights and implications for integrated whitefly management strategies.",12913,41410149,,,"Targeting vacuolar ATPase in tobacco whitefly, Bemisia tabaci (Gennadius): Insights and implications for integrated whitefly management strategies.",https://pubmed.ncbi.nlm.nih.gov/41410149/,PubMed abstract sentence 2,silencing,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0056,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,15574,B,no,,,siRNA,,offtarget candidate; matched derived terms: transcriptome; source title: Diel modulation of perireceptor activity influences olfactory sensitivity in diurnal and nocturnal mosquitoes.,13445,39887616,,10.1111/febs.17418,Diel modulation of perireceptor activity influences olfactory sensitivity in diurnal and nocturnal mosquitoes.,https://pubmed.ncbi.nlm.nih.gov/39887616/,PubMed abstract sentence 6,transcriptome,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0057,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,12720,B,no,,,siRNA,,offtarget candidate; matched derived terms: transcriptome; source title: Genome-wide identification of the phospholipase gene family in Panax notoginseng and functional analysis of PnPLA1-8 response to Fusarium oxysporum infection.,6405,41655508,,10.1016/j.plaphy.2026.111105,Genome-wide identification of the phospholipase gene family in Panax notoginseng and functional analysis of PnPLA1-8 response to Fusarium oxysporum infection.,https://pubmed.ncbi.nlm.nih.gov/41655508/,PubMed abstract sentence 7,transcriptome,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0058,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,11263,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: siRNA-mediated inhibition of NTT-MMP-2 reduces oxidative stress and apoptotic signaling in an ex vivo model of ischemia/reperfusion injury.,3410,41423636,PMC12830612,10.1038/s41598-025-32875-1,siRNA-mediated inhibition of NTT-MMP-2 reduces oxidative stress and apoptotic signaling in an ex vivo model of ischemia/reperfusion injury.,https://pubmed.ncbi.nlm.nih.gov/41423636/,PubMed abstract sentence 8,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0059,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,13400,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: TAK-242 inhibits toll-like receptor-4 signaling and attenuates cancer-associated muscle atrophy via the p38-C/EBPβ pathway.,8030,41123701,,10.1007/s10735-025-10587-0,TAK-242 inhibits toll-like receptor-4 signaling and attenuates cancer-associated muscle atrophy via the p38-C/EBPβ pathway.,https://pubmed.ncbi.nlm.nih.gov/41123701/,PubMed abstract sentence 10,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0060,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,13512,B,no,,,siRNA,,offtarget candidate; matched derived terms: seed; source title: Overexpression of the Wild Soybean Expansin Gene GsEXPB1 Enhances Salt Stress Tolerance in Transgenic Soybeans.,8245,41012003,PMC12473410,10.3390/plants14182851,Overexpression of the Wild Soybean Expansin Gene GsEXPB1 Enhances Salt Stress Tolerance in Transgenic Soybeans.,https://pubmed.ncbi.nlm.nih.gov/41012003/,PubMed abstract sentence 8,seed,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0061,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,12393,B,no,,,siRNA,,offtarget candidate; matched derived terms: off-target; source title: Programmable Lipid Functionalization of Nucleic Acid Nanoparticles Modulates Liver Cell-Type Targeting.,5685,41881029,PMC13067242,10.1021/acsami.5c24581,Programmable Lipid Functionalization of Nucleic Acid Nanoparticles Modulates Liver Cell-Type Targeting.,https://pubmed.ncbi.nlm.nih.gov/41881029/,PubMed abstract sentence 5,off-target,reject,curator_rejected,reject reason: methods source location is not an off-target assay result,,,,,,,,TRUE
iv-reject-0062,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,11826,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: Structural basis for RISC assembly of human Argonaute2.,4436,42190652,,10.1016/j.molcel.2026.04.029,Structural basis for RISC assembly of human Argonaute2.,https://pubmed.ncbi.nlm.nih.gov/42190652/,PubMed abstract sentence 1,silencing,reject,curator_rejected,reject reason: off-target mention is not supported by primary analysis,,,,,,,,TRUE
iv-reject-0063,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,40625,B,no,,,siRNA,,full-text off-target candidate; title/source terms=shrna; source title: A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation.,24882,29099486,PMC5762845,10.1038/cdd.2017.158,A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation.,https://pubmed.ncbi.nlm.nih.gov/29099486/,PMC full text high-precision preselection,shrna,reject,curator_rejected,reject reason: no explicit molecule name in verified source context,,,,,,,,TRUE
iv-reject-0064,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,25355,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=silencing; source title: Robust hepatic gene silencing for functional studies using helper-dependent adenoviral vectors.,24270,18828727,PMC2855247,10.1089/hum.2008.081,Robust hepatic gene silencing for functional studies using helper-dependent adenoviral vectors.,https://pubmed.ncbi.nlm.nih.gov/18828727/,PubMed title,silencing,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0065,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,29393,B,no,,,siRNA,,offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=silencing; source title: MicroRNA-dependent development revealed by RNA interference-mediated gene silencing of LmDicer1 in the migratory locust.,28308,23955825,,10.1111/j.1744-7917.2012.01542.x,MicroRNA-dependent development revealed by RNA interference-mediated gene silencing of LmDicer1 in the migratory locust.,https://pubmed.ncbi.nlm.nih.gov/23955825/,PubMed title,silencing,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0066,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,15172,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: Ionizable polymeric micelles (IPMs) for efficient siRNA delivery.,12405,39753560,PMC11699125,10.1038/s41467-024-55721-w,Ionizable polymeric micelles (IPMs) for efficient siRNA delivery.,https://pubmed.ncbi.nlm.nih.gov/39753560/,PubMed abstract sentence 4,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0067,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,11791,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: Semaglutide Inhibits Osteoblast Ferroptosis Induced by Diabetic Periodontitis via Modulating the Wnt5a/Ror2/p38 MAPK Signaling Pathway.,4373,42206237,PMC13209148,10.2147/DDDT.S599539,Semaglutide Inhibits Osteoblast Ferroptosis Induced by Diabetic Periodontitis via Modulating the Wnt5a/Ror2/p38 MAPK Signaling Pathway.,https://pubmed.ncbi.nlm.nih.gov/42206237/,PubMed abstract sentence 11,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0068,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,27257,B,no,,,siRNA,,offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=microarray; source title: Microarray analyses of gene expression during the Tetrahymena thermophila life cycle.,26172,19204800,PMC2636879,10.1371/journal.pone.0004429,Microarray analyses of gene expression during the Tetrahymena thermophila life cycle.,https://pubmed.ncbi.nlm.nih.gov/19204800/,PubMed title,microarray,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0069,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,12943,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: Adenylate Kinase 2 Promotes Tumor Progression in Small-cell Lung Cancer via PI3K/AKT/mTOR Signaling.,6898,41469111,,10.21873/anticanres.17935,Adenylate Kinase 2 Promotes Tumor Progression in Small-cell Lung Cancer via PI3K/AKT/mTOR Signaling.,https://pubmed.ncbi.nlm.nih.gov/41469111/,PubMed abstract sentence 9,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0070,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,25219,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=silencing; source title: Adeno-associated virus-delivered short hairpin-structured RNA for androgen receptor gene silencing induces tumor eradication of prostate cancer xenografts in nude mice: a preclinical study.,24134,19642108,,10.1002/ijc.24778,Adeno-associated virus-delivered short hairpin-structured RNA for androgen receptor gene silencing induces tumor eradication of prostate cancer xenografts in nude mice: a preclinical study.,https://pubmed.ncbi.nlm.nih.gov/19642108/,PubMed title,silencing,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0071,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,10770,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: Predicting Clinical Pharmacokinetics/Pharmacodynamics and Impact of Organ Impairment on siRNA-Based Therapeutics Using a Mechanistic Physiologically-Based Pharmacokinetic-Pharmacodynamic Model.,1918,38282246,,10.1002/cpt.3160,Predicting Clinical Pharmacokinetics/Pharmacodynamics and Impact of Organ Impairment on siRNA-Based Therapeutics Using a Mechanistic Physiologically-Based Pharmacokinetic-Pharmacodynamic Model.,https://pubmed.ncbi.nlm.nih.gov/38282246/,PubMed abstract sentence 1,silencing,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0072,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,23179,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=silencing; source title: RNAi prodrugs targeting Plk1 induce specific gene silencing in primary cells from pediatric T-acute lymphoblastic leukemia patients.,22094,28684168,,10.1016/j.jconrel.2017.07.002,RNAi prodrugs targeting Plk1 induce specific gene silencing in primary cells from pediatric T-acute lymphoblastic leukemia patients.,https://pubmed.ncbi.nlm.nih.gov/28684168/,PubMed title,silencing,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0073,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,24067,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=silencing; source title: Varying the nucleic acid composition of siRNA molecules dramatically varies the duration and degree of gene silencing.,22982,12746552,,10.1385/MB:24:2:111,Varying the nucleic acid composition of siRNA molecules dramatically varies the duration and degree of gene silencing.,https://pubmed.ncbi.nlm.nih.gov/12746552/,PubMed title,silencing,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0074,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,27722,B,no,,,siRNA,,offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=transcriptome; source title: Transcriptome analysis in cotton boll weevil (Anthonomus grandis) and RNA interference in insect pests.,26637,24386449,PMC3874031,10.1371/journal.pone.0085079,Transcriptome analysis in cotton boll weevil (Anthonomus grandis) and RNA interference in insect pests.,https://pubmed.ncbi.nlm.nih.gov/24386449/,PubMed title,transcriptome,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0075,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,12480,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: Sspdhx Related to the Development and Virulence of Sclerotinia sclerotiorum Represents a Potential RNAi Target for Controlling Sclerotinia Disease.,5859,41839654,PMC13097459,10.1111/mpp.70244,Sspdhx Related to the Development and Virulence of Sclerotinia sclerotiorum Represents a Potential RNAi Target for Controlling Sclerotinia Disease.,https://pubmed.ncbi.nlm.nih.gov/41839654/,PubMed abstract sentence 2,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0076,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,40756,B,no,,,siRNA,,full-text off-target candidate; title/source terms=rnai; source title: Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.,22622,27033334,PMC4898164,10.3109/13506129.2016.1160882,Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.,https://pubmed.ncbi.nlm.nih.gov/27033334/,PMC full text high-precision preselection,rnai,reject,curator_rejected,reject reason: anchor text lacks specific off-target evidence,,,,,,,,TRUE
iv-reject-0077,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,11723,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells.,4242,26944796,,10.1016/j.biochi.2016.02.015,Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells.,https://pubmed.ncbi.nlm.nih.gov/26944796/,PubMed abstract sentence 5,silencing,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0078,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,12748,B,no,,,siRNA,,offtarget candidate; matched derived terms: transcriptome; source title: Tomato spotted wilt virus exploits Halloween genes to accelerate development of Frankliniella occidentalis.,6477,41630458,,10.1002/ps.70600,Tomato spotted wilt virus exploits Halloween genes to accelerate development of Frankliniella occidentalis.,https://pubmed.ncbi.nlm.nih.gov/41630458/,PubMed abstract sentence 4,transcriptome,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0079,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,20044,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=silencing; source title: Silencing of GmFAD3 gene by siRNA leads to low alpha-linolenic acids (18:3) of fad3-mutant phenotype in soybean [Glycine max (Merr.)].,18959,18256901,,10.1007/s11248-008-9167-6,Silencing of GmFAD3 gene by siRNA leads to low alpha-linolenic acids (18:3) of fad3-mutant phenotype in soybean [Glycine max (Merr.)].,https://pubmed.ncbi.nlm.nih.gov/18256901/,PubMed title,silencing,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0080,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,40956,B,no,,,siRNA,,full-text off-target candidate; title/source terms=sirna; source title: Enhanced intrapulmonary delivery of anticancer siRNA for lung cancer therapy using cationic ethylphosphocholine-based nanolipoplexes.,22115,23380818,PMC3616525,10.1038/mt.2013.10,Enhanced intrapulmonary delivery of anticancer siRNA for lung cancer therapy using cationic ethylphosphocholine-based nanolipoplexes.,https://pubmed.ncbi.nlm.nih.gov/23380818/,PMC full text high-precision preselection,sirna,reject,curator_rejected,reject reason: anchor text lacks specific off-target evidence,,,,,,,,TRUE
iv-reject-0081,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,20026,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=mirna; source title: High-throughput approaches for miRNA expression analysis.,18941,19802592,,10.1007/978-1-60327-005-2_8,High-throughput approaches for miRNA expression analysis.,https://pubmed.ncbi.nlm.nih.gov/19802592/,PubMed title,mirna,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0082,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,16459,B,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=off-target, seed; source title: siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect.",15374,19948054,PMC2791777,10.1186/1471-2105-10-392,siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect.,https://pubmed.ncbi.nlm.nih.gov/19948054/,PubMed title,off-target;seed,reject,curator_rejected,reject reason: non-therapeutic oligonucleotide method/tool source,,,,,,,,TRUE
iv-reject-0083,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,23551,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=silencing; source title: Gene silencing by systemic delivery of synthetic siRNAs in adult mice.,22466,12654261,,10.1016/s0022-2836(03)00181-5,Gene silencing by systemic delivery of synthetic siRNAs in adult mice.,https://pubmed.ncbi.nlm.nih.gov/12654261/,PubMed title,silencing,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0084,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,11246,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: ASGPR-targeted micelles co-delivering lenvatinib and COP1 siRNA for hepatocellular carcinoma via dual-targeting.,3379,41046080,,10.1016/j.ejps.2025.107308,ASGPR-targeted micelles co-delivering lenvatinib and COP1 siRNA for hepatocellular carcinoma via dual-targeting.,https://pubmed.ncbi.nlm.nih.gov/41046080/,PubMed abstract sentence 3,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0085,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,26728,B,no,,,siRNA,,offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=transcriptome; source title: Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts.,25643,28698228,,10.1152/physiolgenomics.00026.2017,Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts.,https://pubmed.ncbi.nlm.nih.gov/28698228/,PubMed title,transcriptome,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0086,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,24471,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=mirna; source title: siRNA and miRNA for the treatment of cancer.,23386,19785069,,,siRNA and miRNA for the treatment of cancer.,https://pubmed.ncbi.nlm.nih.gov/19785069/,PubMed title,mirna,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0087,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,17861,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=microarray; source title: Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects.,16776,19732285,,10.1111/j.1471-4159.2009.06373.x,Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects.,https://pubmed.ncbi.nlm.nih.gov/19732285/,PubMed title,microarray,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0088,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,12369,B,no,,,siRNA,,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: SIREN: suite for intelligent RNAi design and evaluation of nucleotide sequences.",5640,41890811,PMC13012889,10.1093/bioadv/vbag075,SIREN: suite for intelligent RNAi design and evaluation of nucleotide sequences.,https://pubmed.ncbi.nlm.nih.gov/41890811/,PubMed abstract sentence 3,off-target;transcriptome,reject,curator_rejected,reject reason: non-therapeutic oligonucleotide method/tool source,,,,,,,,TRUE
iv-reject-0089,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,25507,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=silencing; source title: Silencing of VAMP3 inhibits cell migration and integrin-mediated adhesion.,24422,19159614,PMC2716655manuscript-id: NIHMS97507,10.1016/j.bbrc.2009.01.036,Silencing of VAMP3 inhibits cell migration and integrin-mediated adhesion.,https://pubmed.ncbi.nlm.nih.gov/19159614/,PubMed title,silencing,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0090,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,15398,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: Ferritin Mitochondrial (FTMT)-Driven Mitochondrial Ferroptosis in Vascular Smooth Muscle Cells: A Role of NCOA4 in Atherosclerosis Pathogenesis and Modulation by Gualou-Xiebai.,12921,41374003,PMC12694305,10.3390/nu17233713,Ferritin Mitochondrial (FTMT)-Driven Mitochondrial Ferroptosis in Vascular Smooth Muscle Cells: A Role of NCOA4 in Atherosclerosis Pathogenesis and Modulation by Gualou-Xiebai.,https://pubmed.ncbi.nlm.nih.gov/41374003/,PubMed abstract sentence 13,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0091,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,18023,B,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=seed; source title: Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells.",16938,24561616,PMC4005638,10.1093/nar/gku153,"Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells.",https://pubmed.ncbi.nlm.nih.gov/24561616/,PubMed title,seed,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0092,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,39672,B,no,,,siRNA,,full-text off-target candidate; title/source terms=rnai; source title: Comparison of T7 In Vitro Transcription and E. coli Expression Systems for RNAi-Based Control of Euproctis pseudoconspersa by Targeting EpCHSA.,4448,42188119,PMC13207690,10.3390/insects17050453,Comparison of T7 In Vitro Transcription and E. coli Expression Systems for RNAi-Based Control of Euproctis pseudoconspersa by Targeting EpCHSA.,https://pubmed.ncbi.nlm.nih.gov/42188119/,PMC full text high-precision preselection,rnai,reject,curator_rejected,"{""reason"": ""GATE 1 fail: dsRNA production is for agricultural RNAi-based biopesticide development in an insect pest, outside therapeutic oligonucleotide scope."", ""grounding_quote"": """", ""source_pmid"": ""42188119"", ""candidate_domain"": ""offtarget""}",,,,,,,,TRUE
iv-reject-0093,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,15181,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: Capturing Hydrophilic Chemotherapeutics Agents Into siRNA-Encapsulated Vesicle-Like Nanoparticles for Convenient ICB-Chemo Combination Therapy.,12424,39498748,,10.1002/smll.202404073,Capturing Hydrophilic Chemotherapeutics Agents Into siRNA-Encapsulated Vesicle-Like Nanoparticles for Convenient ICB-Chemo Combination Therapy.,https://pubmed.ncbi.nlm.nih.gov/39498748/,PubMed abstract sentence 5,silencing,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0094,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,25610,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=silencing; source title: BARF1 gene silencing triggers caspase-dependent mitochondrial apoptosis in Epstein-Barr virus-positive malignant cells.,24525,25740140,,10.1007/s12038-015-9502-z,BARF1 gene silencing triggers caspase-dependent mitochondrial apoptosis in Epstein-Barr virus-positive malignant cells.,https://pubmed.ncbi.nlm.nih.gov/25740140/,PubMed title,silencing,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0095,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,25040,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=silencing; source title: Silencing calcineurin A subunit reduces SERCA2 expression in cardiac myocytes.,23955,21057045,PMC3023267,10.1152/ajpheart.00841.2010,Silencing calcineurin A subunit reduces SERCA2 expression in cardiac myocytes.,https://pubmed.ncbi.nlm.nih.gov/21057045/,PubMed title,silencing,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0096,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,12928,B,no,,,siRNA,,offtarget candidate; matched derived terms: transcriptome; source title: Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton.,6864,41486675,PMC12970271,10.1002/advs.202507766,Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton.,https://pubmed.ncbi.nlm.nih.gov/41486675/,PubMed abstract sentence 2,transcriptome,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0097,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,14045,B,no,,,siRNA,,offtarget candidate; matched derived terms: transcriptome; source title: DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway.,9538,40380281,PMC12085079,10.1186/s13148-025-01874-4,DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway.,https://pubmed.ncbi.nlm.nih.gov/40380281/,PubMed abstract sentence 5,transcriptome,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0098,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,24778,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=silencing; source title: Sticky overhangs enhance siRNA-mediated gene silencing.,23693,17913877,PMC2042160,10.1073/pnas.0707831104,Sticky overhangs enhance siRNA-mediated gene silencing.,https://pubmed.ncbi.nlm.nih.gov/17913877/,PubMed title,silencing,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0099,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,20022,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=transcriptome; source title: Transcriptome profiling of human FoxP3+ regulatory T cells.,18937,26686412,PMC4761514manuscript-id: NIHMS744399,10.1016/j.humimm.2015.12.004,Transcriptome profiling of human FoxP3+ regulatory T cells.,https://pubmed.ncbi.nlm.nih.gov/26686412/,PubMed title,transcriptome,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0100,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,11765,B,no,,,siRNA,,offtarget candidate; matched derived terms: silencing; source title: MicroRNA Lse-novel_mir63 regulates metamorphosis and fumigant tolerance by targeting CYP4G249 in Lasioderma serricorne.,4326,42219662,,10.1002/ps.70977,MicroRNA Lse-novel_mir63 regulates metamorphosis and fumigant tolerance by targeting CYP4G249 in Lasioderma serricorne.,https://pubmed.ncbi.nlm.nih.gov/42219662/,PubMed abstract sentence 7,silencing,reject,curator_rejected,reject reason: source location does not support specific off-target evidence,,,,,,,,TRUE
iv-reject-0101,candidate_reject_control,candidate_reject_control/offtarget/B/siRNA,offtarget,curation_candidate,16436,B,no,,,siRNA,,offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=off-target; source title: Detecting microRNA binding and siRNA off-target effects from expression data.,15351,18978784,PMC2635553manuscript-id: UKMS2618,10.1038/nmeth.1267,Detecting microRNA binding and siRNA off-target effects from expression data.,https://pubmed.ncbi.nlm.nih.gov/18978784/,PubMed title,off-target,reject,curator_rejected,"reject reason: no explicit molecule, target, or cohort for verified release evidence",,,,,,,,TRUE
iv-reject-0102,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,31460,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Molecular characterisation of the t(1;15)(p22;q22) translocation in the prostate cancer cell line LNCaP.",30375,16276089,,10.1159/000087512,Molecular characterisation of the t(1;15)(p22;q22) translocation in the prostate cancer cell line LNCaP.,https://pubmed.ncbi.nlm.nih.gov/16276089/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0103,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,33199,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Morpholino knockdown of lysyl oxidase impairs zebrafish development, and reflects some aspects of copper metabolism disorders.",32114,18467084,,10.1016/j.matbio.2008.03.002,"Morpholino knockdown of lysyl oxidase impairs zebrafish development, and reflects some aspects of copper metabolism disorders.",https://pubmed.ncbi.nlm.nih.gov/18467084/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0104,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,34977,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Phylogenetic characterization and prevalence of ""Spirobacillus cienkowskii,"" a red-pigmented, spiral-shaped bacterial pathogen of freshwater Daphnia species.",33892,18192404,PMC2258617,10.1128/AEM.02438-07,"Phylogenetic characterization and prevalence of ""Spirobacillus cienkowskii,"" a red-pigmented, spiral-shaped bacterial pathogen of freshwater Daphnia species.",https://pubmed.ncbi.nlm.nih.gov/18192404/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0105,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,34367,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Underexpression of the plant NOTCHLESS gene, encoding a WD-repeat protein, causes pleitropic phenotype during plant development.",33282,17086402,,10.1007/s00425-006-0420-z,"Underexpression of the plant NOTCHLESS gene, encoding a WD-repeat protein, causes pleitropic phenotype during plant development.",https://pubmed.ncbi.nlm.nih.gov/17086402/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0106,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,31617,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Inter-genus gene expression analysis in livestock fibroblasts using reference gene validation based upon a multi-species primer set.",30532,31412093,PMC6693880,10.1371/journal.pone.0221170,Inter-genus gene expression analysis in livestock fibroblasts using reference gene validation based upon a multi-species primer set.,https://pubmed.ncbi.nlm.nih.gov/31412093/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0107,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,36925,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage.",35840,27430048,PMC5329897,10.4161/1949095X.2014.992181,Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage.,https://pubmed.ncbi.nlm.nih.gov/27430048/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0108,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,34829,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Luminescent chemical sensing, biosensing, and screening using upconverting nanoparticles.",33744,21516435,,10.1007/128_2010_98,"Luminescent chemical sensing, biosensing, and screening using upconverting nanoparticles.",https://pubmed.ncbi.nlm.nih.gov/21516435/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0109,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,36339,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.",35254,15466481,PMC2172518,10.1083/jcb.200403067,Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.,https://pubmed.ncbi.nlm.nih.gov/15466481/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0110,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,33246,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Overexpression of immunoglobulin G prompts cell proliferation and inhibits cell apoptosis in human urothelial carcinoma.",32161,23483488,PMC3661916,10.1007/s13277-013-0717-z,Overexpression of immunoglobulin G prompts cell proliferation and inhibits cell apoptosis in human urothelial carcinoma.,https://pubmed.ncbi.nlm.nih.gov/23483488/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0111,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,32379,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Solid-phase synthesis of oligopurine deoxynucleic guanidine (DNG) and analysis of binding with DNA oligomers.",31294,11376155,PMC55709,10.1093/nar/29.11.2370,Solid-phase synthesis of oligopurine deoxynucleic guanidine (DNG) and analysis of binding with DNA oligomers.,https://pubmed.ncbi.nlm.nih.gov/11376155/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0112,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,31184,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Abated microRNA-195 expression protected mesangial cells from apoptosis in early diabetic renal injury in mice.",30099,21983986,,10.5301/jn.5000034,Abated microRNA-195 expression protected mesangial cells from apoptosis in early diabetic renal injury in mice.,https://pubmed.ncbi.nlm.nih.gov/21983986/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0113,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,30532,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Zygotic expression of Exostosin1 (Ext1) is required for BMP signaling and establishment of dorsal-ventral pattern in Xenopus.",29447,24860992,,10.1387/ijdb.130257as,Zygotic expression of Exostosin1 (Ext1) is required for BMP signaling and establishment of dorsal-ventral pattern in Xenopus.,https://pubmed.ncbi.nlm.nih.gov/24860992/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0114,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,30030,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Leveraging human genomic information to identify nonhuman primate sequences for expression array development.",28945,16288651,PMC1314899,10.1186/1471-2164-6-160,Leveraging human genomic information to identify nonhuman primate sequences for expression array development.,https://pubmed.ncbi.nlm.nih.gov/16288651/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0115,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,37330,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Comparative analysis of gene expression profiles in normal hip human cartilage and cartilage from patients with necrosis of the femoral head.",36245,27146865,PMC4857375,10.1186/s13075-016-0991-4,Comparative analysis of gene expression profiles in normal hip human cartilage and cartilage from patients with necrosis of the femoral head.,https://pubmed.ncbi.nlm.nih.gov/27146865/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0116,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,37588,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: prox1b Activity is essential in zebrafish lymphangiogenesis.",36503,20976189,PMC2956630,10.1371/journal.pone.0013170,prox1b Activity is essential in zebrafish lymphangiogenesis.,https://pubmed.ncbi.nlm.nih.gov/20976189/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0117,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,33808,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Ordered differential display.",32723,16264221,,10.1385/1-59259-968-0:059,Ordered differential display.,https://pubmed.ncbi.nlm.nih.gov/16264221/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0118,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,30767,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: A comparative fluorescent beacon-based method for serum microRNA quantification.",29682,25765279,,10.2116/analsci.31.231,A comparative fluorescent beacon-based method for serum microRNA quantification.,https://pubmed.ncbi.nlm.nih.gov/25765279/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0119,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,31596,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Combinational synthesis of oligonucleotides and assembly fabrication of oligonucleotide array.",30511,15708507,,10.1016/j.colsurfb.2004.10.018,Combinational synthesis of oligonucleotides and assembly fabrication of oligonucleotide array.,https://pubmed.ncbi.nlm.nih.gov/15708507/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0120,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,31111,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Sub-femtomolar detection of DNA and discrimination of mutant strands using microwell-array assisted digital enzyme-linked oligonucleotide assay.",30026,30340684,,10.1016/j.aca.2018.08.056,Sub-femtomolar detection of DNA and discrimination of mutant strands using microwell-array assisted digital enzyme-linked oligonucleotide assay.,https://pubmed.ncbi.nlm.nih.gov/30340684/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0121,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,35191,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features.",34106,10980135,PMC1885704,10.1016/S0002-9440(10)64609-3,Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features.,https://pubmed.ncbi.nlm.nih.gov/10980135/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0122,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,33067,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Development of a molecular cytogenetic recombination assay for barley.",31982,20551612,,10.1159/000314335,Development of a molecular cytogenetic recombination assay for barley.,https://pubmed.ncbi.nlm.nih.gov/20551612/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0123,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,31166,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Uncovering gene regulatory networks during mouse fetal germ cell development.",30081,21148109,PMC3062041,10.1095/biolreprod.110.088443,Uncovering gene regulatory networks during mouse fetal germ cell development.,https://pubmed.ncbi.nlm.nih.gov/21148109/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0124,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,36524,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Cofactome analyses reveal enhanced flux of carbon into oil for potential biofuel production.",35439,21615570,,10.1111/j.1365-313X.2011.04654.x,Cofactome analyses reveal enhanced flux of carbon into oil for potential biofuel production.,https://pubmed.ncbi.nlm.nih.gov/21615570/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0125,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,31410,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: A novel type of hemocytes localizing melanization with high-spreading behavior in Mythimna separata.",30325,24986040,,10.1002/arch.21173,A novel type of hemocytes localizing melanization with high-spreading behavior in Mythimna separata.,https://pubmed.ncbi.nlm.nih.gov/24986040/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0126,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,37853,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Gene expression analysis in response to low and high temperature and oxidative stresses in rice: combination of stresses evokes different transcriptional changes as against stresses applied individually.",36768,23116677,,10.1016/j.plantsci.2012.09.008,Gene expression analysis in response to low and high temperature and oxidative stresses in rice: combination of stresses evokes different transcriptional changes as against stresses applied individually.,https://pubmed.ncbi.nlm.nih.gov/23116677/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0127,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,34170,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Development and Molecular Cytogenetic Identification of a Novel Wheat-Leymus mollis Lm#7Ns (7D) Disomic Substitution Line with Stripe Rust Resistance.",33085,26465140,PMC4605682,10.1371/journal.pone.0140227,Development and Molecular Cytogenetic Identification of a Novel Wheat-Leymus mollis Lm#7Ns (7D) Disomic Substitution Line with Stripe Rust Resistance.,https://pubmed.ncbi.nlm.nih.gov/26465140/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0128,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,31982,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Rapid analysis of chromosome aberrations in mouse B lymphocytes by PNA-FISH.",30897,25177909,PMC4540087,10.3791/51806,Rapid analysis of chromosome aberrations in mouse B lymphocytes by PNA-FISH.,https://pubmed.ncbi.nlm.nih.gov/25177909/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0129,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,29815,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Biophysical and cellular-uptake properties of mixed-sequence pyrrolidine-amide oligonucleotide mimics.",28730,22076794,,10.1002/chem.201101950,Biophysical and cellular-uptake properties of mixed-sequence pyrrolidine-amide oligonucleotide mimics.,https://pubmed.ncbi.nlm.nih.gov/22076794/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0130,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,30921,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis.",29836,16696860,PMC1475625,10.1186/1742-4690-3-26,Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis.,https://pubmed.ncbi.nlm.nih.gov/16696860/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0131,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,36741,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Development of a method for recovering rickettsial RNA from infected cells to analyze gene expression profiling of obligate intracellular bacteria.",35656,17964675,,10.1016/j.mimet.2007.09.017,Development of a method for recovering rickettsial RNA from infected cells to analyze gene expression profiling of obligate intracellular bacteria.,https://pubmed.ncbi.nlm.nih.gov/17964675/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0132,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,34356,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Transcriptomic responses to salinity stress in invasive and native blue mussels (genus Mytilus).",33271,21199031,,10.1111/j.1365-294X.2010.04973.x,Transcriptomic responses to salinity stress in invasive and native blue mussels (genus Mytilus).,https://pubmed.ncbi.nlm.nih.gov/21199031/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0133,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,31063,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Research Techniques Made Simple: Methodology and Clinical Applications of RNA Sequencing.",29978,27450500,,10.1016/j.jid.2016.06.003,Research Techniques Made Simple: Methodology and Clinical Applications of RNA Sequencing.,https://pubmed.ncbi.nlm.nih.gov/27450500/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0134,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,35206,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Initiation of DNA replication at the Chinese hamster origin oriGNAI3 relies on local sequences and/or chromatin structures, but not on transcription of the nearby GNAI3 gene.",34121,10075990,PMC148362,10.1093/nar/27.7.1600,"Initiation of DNA replication at the Chinese hamster origin oriGNAI3 relies on local sequences and/or chromatin structures, but not on transcription of the nearby GNAI3 gene.",https://pubmed.ncbi.nlm.nih.gov/10075990/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0135,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,35405,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Benzo(a)pyrene decreases brain and ovarian aromatase mRNA expression in Fundulus heteroclitus.",34320,18571745,PMC2530897manuscript-id: NIHMS63869,10.1016/j.aquatox.2008.05.006,Benzo(a)pyrene decreases brain and ovarian aromatase mRNA expression in Fundulus heteroclitus.,https://pubmed.ncbi.nlm.nih.gov/18571745/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0136,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,33804,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy.",32719,9811345,PMC1853410,10.1016/s0002-9440(10)65741-0,Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy.,https://pubmed.ncbi.nlm.nih.gov/9811345/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0137,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,31251,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: C5-functionalized DNA, LNA, and α-L-LNA: positional control of polarity-sensitive fluorophores leads to improved SNP-typing.",30166,21328492,,10.1002/chem.201002109,"C5-functionalized DNA, LNA, and α-L-LNA: positional control of polarity-sensitive fluorophores leads to improved SNP-typing.",https://pubmed.ncbi.nlm.nih.gov/21328492/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0138,candidate_reject_control,candidate_reject_control/offtarget/C/ASO,offtarget,curation_candidate,37959,C,no,,,ASO,,"offtarget candidate; derived PubMed query=aso_oligo_offtarget; terms=aso, oligonucleotide, off-target; source title: Transcriptomics and proteomics analyses of the PACAP38 influenced ischemic brain in permanent middle cerebral artery occlusion model mice.",36874,23176072,PMC3526409,10.1186/1742-2094-9-256,Transcriptomics and proteomics analyses of the PACAP38 influenced ischemic brain in permanent middle cerebral artery occlusion model mice.,https://pubmed.ncbi.nlm.nih.gov/23176072/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,aso;oligonucleotide;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0139,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,21582,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Characterization of a dual-action adulticidal and larvicidal interfering RNA pesticide targeting the Shaker gene of multiple disease vector mosquitoes.",20497,32687496,PMC7392347,10.1371/journal.pntd.0008479,Characterization of a dual-action adulticidal and larvicidal interfering RNA pesticide targeting the Shaker gene of multiple disease vector mosquitoes.,https://pubmed.ncbi.nlm.nih.gov/32687496/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0140,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,25347,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: beta-Catenin promotes self-renewal of skeletal-muscle satellite cells.",24262,18397993,,10.1242/jcs.024885,beta-Catenin promotes self-renewal of skeletal-muscle satellite cells.,https://pubmed.ncbi.nlm.nih.gov/18397993/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0141,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28469,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Functional genomics screen with pooled shRNA library and gene expression profiling with extracts of Azadirachta indica identify potential pathways for therapeutic targets in head and neck squamous cell carcinoma.",27384,30842898,PMC6398373,10.7717/peerj.6464,Functional genomics screen with pooled shRNA library and gene expression profiling with extracts of Azadirachta indica identify potential pathways for therapeutic targets in head and neck squamous cell carcinoma.,https://pubmed.ncbi.nlm.nih.gov/30842898/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0142,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,21745,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Recent attempts at RNAi-mediated P-glycoprotein downregulation for reversal of multidrug resistance in cancer.",20660,21523793,,10.1002/med.20244,Recent attempts at RNAi-mediated P-glycoprotein downregulation for reversal of multidrug resistance in cancer.,https://pubmed.ncbi.nlm.nih.gov/21523793/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0143,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,21106,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: AIE Featured Inorganic-Organic Core@Shell Nanoparticles for High-Efficiency siRNA Delivery and Real-Time Monitoring.",20021,30829039,,10.1021/acs.nanolett.8b04677,AIE Featured Inorganic-Organic Core@Shell Nanoparticles for High-Efficiency siRNA Delivery and Real-Time Monitoring.,https://pubmed.ncbi.nlm.nih.gov/30829039/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0144,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,20588,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Folate-targeted star-shaped cationic copolymer co-delivering docetaxel and MMP-9 siRNA for nasopharyngeal carcinoma therapy.",19503,27259274,PMC5173113,10.18632/oncotarget.9771,Folate-targeted star-shaped cationic copolymer co-delivering docetaxel and MMP-9 siRNA for nasopharyngeal carcinoma therapy.,https://pubmed.ncbi.nlm.nih.gov/27259274/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0145,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,25530,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: siRNA-mediated suppression of collagen type iv alpha 2 (COL4A2) mRNA inhibits triple-negative breast cancer cell proliferation and migration.",24445,27906681,PMC5356825,10.18632/oncotarget.13716,siRNA-mediated suppression of collagen type iv alpha 2 (COL4A2) mRNA inhibits triple-negative breast cancer cell proliferation and migration.,https://pubmed.ncbi.nlm.nih.gov/27906681/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0146,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,19545,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: [The impact of cyclophilin A small interfering RNA on the formation of atherosclerotic plaque in apolipoprotein E-deficient mice].",18460,25327603,,,[The impact of cyclophilin A small interfering RNA on the formation of atherosclerotic plaque in apolipoprotein E-deficient mice].,https://pubmed.ncbi.nlm.nih.gov/25327603/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0147,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,17491,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Homeodomain-only protein HOP is a novel modulator of late differentiation in keratinocytes.",16406,21256618,,10.1016/j.ejcb.2010.11.001,Homeodomain-only protein HOP is a novel modulator of late differentiation in keratinocytes.,https://pubmed.ncbi.nlm.nih.gov/21256618/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0148,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,26158,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer.",25073,36289544,PMC9609288,10.1186/s13046-022-02516-w,LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer.,https://pubmed.ncbi.nlm.nih.gov/36289544/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0149,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,19604,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification.",18519,19350388,,10.1007/s10549-009-0380-7,CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification.,https://pubmed.ncbi.nlm.nih.gov/19350388/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0150,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,24660,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Optimization of PEGylated KL4 Peptide for siRNA Delivery with Improved Pulmonary Tolerance.",23575,34014665,,10.1021/acs.molpharmaceut.0c01242,Optimization of PEGylated KL4 Peptide for siRNA Delivery with Improved Pulmonary Tolerance.,https://pubmed.ncbi.nlm.nih.gov/34014665/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0151,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,17472,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: An enhanced U6 promoter for synthesis of short hairpin RNA.",16387,12930974,PMC212820,10.1093/nar/gng098,An enhanced U6 promoter for synthesis of short hairpin RNA.,https://pubmed.ncbi.nlm.nih.gov/12930974/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0152,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,25799,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Enhanced therapeutic effect of Adriamycin on multidrug resistant breast cancer by the ABCG2-siRNA loaded polymeric nanoparticles assisted with ultrasound.",24714,26575421,PMC4791266,10.18632/oncotarget.6085,Enhanced therapeutic effect of Adriamycin on multidrug resistant breast cancer by the ABCG2-siRNA loaded polymeric nanoparticles assisted with ultrasound.,https://pubmed.ncbi.nlm.nih.gov/26575421/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0153,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,26178,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Pathway-specific profiling identifies the NF-kappa B-dependent tumor necrosis factor alpha-regulated genes in epidermal keratinocytes.",25093,15722350,,10.1074/jbc.M411758200,Pathway-specific profiling identifies the NF-kappa B-dependent tumor necrosis factor alpha-regulated genes in epidermal keratinocytes.,https://pubmed.ncbi.nlm.nih.gov/15722350/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0154,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28256,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways.",27171,23637932,PMC3630140,10.1371/journal.pone.0061934,Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways.,https://pubmed.ncbi.nlm.nih.gov/23637932/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0155,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,22994,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: [Effect of RNA interference of CD59 gene on proliferation of non-small cell lung cancer cell line GLC-P in vitro].",21909,26111694,,,[Effect of RNA interference of CD59 gene on proliferation of non-small cell lung cancer cell line GLC-P in vitro].,https://pubmed.ncbi.nlm.nih.gov/26111694/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0156,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,27484,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Reduced expression of FXYD domain containing ion transport regulator 5 in association with hypertension.",26399,22085977,,10.3892/ijmm.2011.837,Reduced expression of FXYD domain containing ion transport regulator 5 in association with hypertension.,https://pubmed.ncbi.nlm.nih.gov/22085977/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0157,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,24441,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Quantitative analysis of topoisomerase II alpha and evaluation of its effects on cell proliferation and apoptosis in glioblastoma cancer stem cells.",23356,22569122,,10.1016/j.neulet.2012.04.071,Quantitative analysis of topoisomerase II alpha and evaluation of its effects on cell proliferation and apoptosis in glioblastoma cancer stem cells.,https://pubmed.ncbi.nlm.nih.gov/22569122/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0158,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,25637,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Edible and cation-free kiwi fruit derived vesicles mediated EGFR-targeted siRNA delivery to inhibit multidrug resistant lung cancer.",24552,36740689,PMC9901103,10.1186/s12951-023-01766-w,Edible and cation-free kiwi fruit derived vesicles mediated EGFR-targeted siRNA delivery to inhibit multidrug resistant lung cancer.,https://pubmed.ncbi.nlm.nih.gov/36740689/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0159,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,20748,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Generation of variable and fixed length siRNA from a novel siRNA expression vector.",19663,16677603,,10.1016/j.bbrc.2006.04.061,Generation of variable and fixed length siRNA from a novel siRNA expression vector.,https://pubmed.ncbi.nlm.nih.gov/16677603/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0160,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,29432,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation.",28347,28205605,PMC5436121,10.1038/npp.2017.31,The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation.,https://pubmed.ncbi.nlm.nih.gov/28205605/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0161,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28353,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Retrotransposon addiction promotes centromere function via epigenetically activated small RNAs.",27268,37577592,PMC10418216,10.1101/2023.08.02.551486,Retrotransposon addiction promotes centromere function via epigenetically activated small RNAs.,https://pubmed.ncbi.nlm.nih.gov/37577592/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0162,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28442,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Non-syndromic mild mental retardation candidate gene CDKL3 regulates neuronal morphogenesis.",27357,20347982,,10.1016/j.nbd.2010.03.015,Non-syndromic mild mental retardation candidate gene CDKL3 regulates neuronal morphogenesis.,https://pubmed.ncbi.nlm.nih.gov/20347982/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0163,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,17545,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Gene regulation by BCL3 in a cervical cancer cell line.",16460,20974051,,10.14712/fb2010056040183,Gene regulation by BCL3 in a cervical cancer cell line.,https://pubmed.ncbi.nlm.nih.gov/20974051/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0164,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,26218,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Synaptotagmin 11 scaffolds MKK7-JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis.",25133,35768842,PMC9241269,10.1186/s13046-022-02420-3,Synaptotagmin 11 scaffolds MKK7-JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis.,https://pubmed.ncbi.nlm.nih.gov/35768842/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0165,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,21897,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass.",20812,18323791,,10.1038/gt.2008.24,Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass.,https://pubmed.ncbi.nlm.nih.gov/18323791/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0166,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,29759,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Isogenic Human-Induced Pluripotent Stem-Cell-Derived Cardiomyocytes Reveal Activation of Wnt Signaling Pathways Underlying Intrinsic Cardiac Abnormalities in Rett Syndrome.",28674,36555252,PMC9779632,10.3390/ijms232415609,Isogenic Human-Induced Pluripotent Stem-Cell-Derived Cardiomyocytes Reveal Activation of Wnt Signaling Pathways Underlying Intrinsic Cardiac Abnormalities in Rett Syndrome.,https://pubmed.ncbi.nlm.nih.gov/36555252/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0167,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,27644,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: NF90/ILF3 is a transcription factor that promotes proliferation over differentiation by hierarchical regulation in K562 erythroleukemia cells.",26559,29590119,PMC5873942,10.1371/journal.pone.0193126,NF90/ILF3 is a transcription factor that promotes proliferation over differentiation by hierarchical regulation in K562 erythroleukemia cells.,https://pubmed.ncbi.nlm.nih.gov/29590119/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0168,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,20229,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Identification of small RNAs in late developmental stage of rice anthers.",19144,18670140,,10.1266/ggs.83.281,Identification of small RNAs in late developmental stage of rice anthers.,https://pubmed.ncbi.nlm.nih.gov/18670140/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0169,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,18717,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Design and evaluation of histidine-rich amphipathic peptides for siRNA delivery.",17632,20393870,,10.1007/s11095-010-0138-2,Design and evaluation of histidine-rich amphipathic peptides for siRNA delivery.,https://pubmed.ncbi.nlm.nih.gov/20393870/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0170,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,16797,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling.",15712,30012564,,10.1158/1078-0432.CCR-17-3125,Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling.,https://pubmed.ncbi.nlm.nih.gov/30012564/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0171,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,17827,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.",16742,22984288,PMC3518139,10.1074/mcp.M112.020255,Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.,https://pubmed.ncbi.nlm.nih.gov/22984288/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0172,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,27716,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Immune competence in insect eggs depends on the extraembryonic serosa.",26631,23732406,,10.1016/j.dci.2013.05.017,Immune competence in insect eggs depends on the extraembryonic serosa.,https://pubmed.ncbi.nlm.nih.gov/23732406/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0173,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,27673,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma.",26588,19155088,,10.1016/j.jhep.2008.10.025,LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma.,https://pubmed.ncbi.nlm.nih.gov/19155088/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0174,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,29741,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains.",28656,32970778,PMC7513999,10.1371/journal.ppat.1008826,The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains.,https://pubmed.ncbi.nlm.nih.gov/32970778/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0175,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,23994,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Recombinant fungal entomopathogen RNAi target insect gene.",22909,27715447,PMC5153893,10.1080/21655979.2016.1146833,Recombinant fungal entomopathogen RNAi target insect gene.,https://pubmed.ncbi.nlm.nih.gov/27715447/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0176,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,22169,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: The Requirement for GW182 Scaffolding Protein Depends on Whether Argonaute Is Mediating Translation, Transcription, or Splicing.",21084,30086238,PMC6124307manuscript-id: NIHMS985687,10.1021/acs.biochem.8b00602,"The Requirement for GW182 Scaffolding Protein Depends on Whether Argonaute Is Mediating Translation, Transcription, or Splicing.",https://pubmed.ncbi.nlm.nih.gov/30086238/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0177,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,19094,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Transcription factor GATA4 associates with mesenchymal-like gene expression in human hepatoblastoma cells.",18009,30074440,,10.1177/1010428318785498,Transcription factor GATA4 associates with mesenchymal-like gene expression in human hepatoblastoma cells.,https://pubmed.ncbi.nlm.nih.gov/30074440/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0178,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,21871,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Cell-penetrating peptides for siRNA delivery to glioblastomas.",20786,29684592,,10.1016/j.peptides.2018.04.015,Cell-penetrating peptides for siRNA delivery to glioblastomas.,https://pubmed.ncbi.nlm.nih.gov/29684592/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0179,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,17321,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.",16236,21505458,PMC3101910,10.1038/bjc.2011.133,Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.,https://pubmed.ncbi.nlm.nih.gov/21505458/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0180,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,26983,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Identification of G protein-coupled receptors required for vitellogenesis and egg development in an insect with panoistic ovary.",25898,32537938,,10.1111/1744-7917.12841,Identification of G protein-coupled receptors required for vitellogenesis and egg development in an insect with panoistic ovary.,https://pubmed.ncbi.nlm.nih.gov/32537938/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0181,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,21825,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Identification of differentially expressed transcripts and translatants targeted by knock-down of endogenous PCBP1.",20740,20624489,,10.1016/j.bbapap.2010.07.002,Identification of differentially expressed transcripts and translatants targeted by knock-down of endogenous PCBP1.,https://pubmed.ncbi.nlm.nih.gov/20624489/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0182,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28160,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy.",27075,23341935,PMC3544824,10.1371/journal.pone.0053287,Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy.,https://pubmed.ncbi.nlm.nih.gov/23341935/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0183,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,25562,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Transcriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration.",24477,25477501,PMC4344930manuscript-id: NIHMS647083,10.1161/CIRCRESAHA.116.304269,Transcriptional reversion of cardiac myocyte fate during mammalian cardiac regeneration.,https://pubmed.ncbi.nlm.nih.gov/25477501/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0184,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,17364,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc.",16279,24317511,,10.1038/onc.2013.505,ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc.,https://pubmed.ncbi.nlm.nih.gov/24317511/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0185,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,22669,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila.",21584,24067655,PMC3799365,10.1073/pnas.1315803110,Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila.,https://pubmed.ncbi.nlm.nih.gov/24067655/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0186,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,18680,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Cloning, expression analysis and functional characterization of an interleukin-1 receptor-associated kinase 4 from Apostichopus japonicus.",17595,30121020,,10.1016/j.molimm.2018.08.006,"Cloning, expression analysis and functional characterization of an interleukin-1 receptor-associated kinase 4 from Apostichopus japonicus.",https://pubmed.ncbi.nlm.nih.gov/30121020/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0187,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28858,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Knockdown of RAD18 inhibits glioblastoma development.",27773,31081138,,10.1002/jcp.28713,Knockdown of RAD18 inhibits glioblastoma development.,https://pubmed.ncbi.nlm.nih.gov/31081138/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0188,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,20678,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells.",19593,12594341,PMC151418,10.1073/pnas.252758799,RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells.,https://pubmed.ncbi.nlm.nih.gov/12594341/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0189,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,22926,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: MicroRNA-146a protects against myocardial ischaemia reperfusion injury by targeting Med1.",21841,31798643,PMC6882197,10.1186/s11658-019-0186-5,MicroRNA-146a protects against myocardial ischaemia reperfusion injury by targeting Med1.,https://pubmed.ncbi.nlm.nih.gov/31798643/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0190,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28271,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.",27186,21931660,PMC3169580,10.1371/journal.pone.0024168,In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.,https://pubmed.ncbi.nlm.nih.gov/21931660/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0191,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,26836,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: New technology and resources for cryptococcal research.",25751,25460849,PMC4433448manuscript-id: NIHMS642991,10.1016/j.fgb.2014.11.001,New technology and resources for cryptococcal research.,https://pubmed.ncbi.nlm.nih.gov/25460849/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0192,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,29471,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: OsASR6 Alleviates Rice Resistance to Xanthomonas oryzae via Transcriptional Suppression of OsCIPK15.",28386,35743079,PMC9223573,10.3390/ijms23126622,OsASR6 Alleviates Rice Resistance to Xanthomonas oryzae via Transcriptional Suppression of OsCIPK15.,https://pubmed.ncbi.nlm.nih.gov/35743079/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0193,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,27226,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Reciprocal regulation of p63 by C/EBP delta in human keratinocytes.",26141,17903252,PMC2148061,10.1186/1471-2199-8-85,Reciprocal regulation of p63 by C/EBP delta in human keratinocytes.,https://pubmed.ncbi.nlm.nih.gov/17903252/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0194,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28222,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma.",27137,25576913,PMC4413612,10.18632/oncotarget.2779,A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma.,https://pubmed.ncbi.nlm.nih.gov/25576913/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0195,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,29323,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Prostaglandin catabolism in Spodoptera exigua, a lepidopteran insect.",28238,32978320,,10.1242/jeb.233221,"Prostaglandin catabolism in Spodoptera exigua, a lepidopteran insect.",https://pubmed.ncbi.nlm.nih.gov/32978320/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0196,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,19595,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.",18510,32194851,PMC7053186,10.7150/thno.40798,CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.,https://pubmed.ncbi.nlm.nih.gov/32194851/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0197,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28699,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: An eye on RNAi in nematode parasites.",27614,21885343,,10.1016/j.pt.2011.07.004,An eye on RNAi in nematode parasites.,https://pubmed.ncbi.nlm.nih.gov/21885343/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0198,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28066,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Evaluation of hepatitis B viral replication and proteomic analysis of HepG2.2.15 cell line after knockdown of HBx.",26981,21669574,,10.1016/s1499-3872(11)60049-0,Evaluation of hepatitis B viral replication and proteomic analysis of HepG2.2.15 cell line after knockdown of HBx.,https://pubmed.ncbi.nlm.nih.gov/21669574/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0199,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,26687,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells.",25602,12875974,PMC1868227,10.1016/S0002-9440(10)63682-6,Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells.,https://pubmed.ncbi.nlm.nih.gov/12875974/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0200,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,21585,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.",20500,19826040,PMC2763324manuscript-id: NIHMS143917,10.1158/0008-5472.CAN-09-1996,microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.,https://pubmed.ncbi.nlm.nih.gov/19826040/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0201,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,18159,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Influence of the loop size and nucleotide composition on AgoshRNA biogenesis and activity.",17074,28569591,PMC5785215,10.1080/15476286.2017.1328349,Influence of the loop size and nucleotide composition on AgoshRNA biogenesis and activity.,https://pubmed.ncbi.nlm.nih.gov/28569591/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0202,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28603,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Optimized reduced representation bisulfite sequencing reveals tissue-specific mCHH islands in maize.",27518,28854962,PMC5577757,10.1186/s13072-017-0148-y,Optimized reduced representation bisulfite sequencing reveals tissue-specific mCHH islands in maize.,https://pubmed.ncbi.nlm.nih.gov/28854962/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0203,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,21456,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation.",20371,20964335,PMC2998752manuscript-id: NIHMS247713,10.1021/bc100346n,Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation.,https://pubmed.ncbi.nlm.nih.gov/20964335/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0204,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,26179,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Specialization and evolution of endogenous small RNA pathways.",25094,17943195,,10.1038/nrg2179,Specialization and evolution of endogenous small RNA pathways.,https://pubmed.ncbi.nlm.nih.gov/17943195/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0205,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,25736,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival.",24651,18829536,PMC4429896manuscript-id: NIHMS675296,10.1158/0008-5472.CAN-08-1320,Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival.,https://pubmed.ncbi.nlm.nih.gov/18829536/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0206,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,27175,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: GmGPA3 is involved in post-Golgi trafficking of storage proteins and cell growth in soybean cotyledons.",26090,32234217,,10.1016/j.plantsci.2020.110423,GmGPA3 is involved in post-Golgi trafficking of storage proteins and cell growth in soybean cotyledons.,https://pubmed.ncbi.nlm.nih.gov/32234217/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0207,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,24420,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Intersection of small RNA pathways in Arabidopsis thaliana sub-nuclear domains.",23335,23776518,PMC3680462,10.1371/journal.pone.0065652,Intersection of small RNA pathways in Arabidopsis thaliana sub-nuclear domains.,https://pubmed.ncbi.nlm.nih.gov/23776518/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0208,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,23312,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancer.",22227,23938591,,10.1016/j.bbadis.2013.08.001,Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancer.,https://pubmed.ncbi.nlm.nih.gov/23938591/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0209,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,21556,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Biogenesis and function of endogenous and exogenous siRNAs.",20471,21956909,,10.1002/wrna.14,Biogenesis and function of endogenous and exogenous siRNAs.,https://pubmed.ncbi.nlm.nih.gov/21956909/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0210,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,24689,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Percutaneous gene therapy heals cranial defects.",23604,23594990,,10.1038/gt.2013.15,Percutaneous gene therapy heals cranial defects.,https://pubmed.ncbi.nlm.nih.gov/23594990/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0211,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,23096,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: A low-abundance class of Dicer-dependent siRNAs produced from a variety of features in C. elegans.",22011,39622635,PMC11694761,10.1101/gr.279083.124,A low-abundance class of Dicer-dependent siRNAs produced from a variety of features in C. elegans.,https://pubmed.ncbi.nlm.nih.gov/39622635/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0212,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,22386,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal.",21301,27239797,,10.1038/nsmb.3235,lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal.,https://pubmed.ncbi.nlm.nih.gov/27239797/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0213,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28701,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: A phylogenomics approach to characterizing sensory neuron membrane proteins (SNMPs) in Lepidoptera.",27616,31911087,,10.1016/j.ibmb.2020.103313,A phylogenomics approach to characterizing sensory neuron membrane proteins (SNMPs) in Lepidoptera.,https://pubmed.ncbi.nlm.nih.gov/31911087/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0214,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,28244,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth.",27159,31022357,PMC6662966,10.1096/fj.201802213RR,Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth.,https://pubmed.ncbi.nlm.nih.gov/31022357/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: non-oligonucleotide editing/silencing modality,,,,,,,,TRUE
iv-reject-0215,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,25663,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi.",24578,28541282,PMC5458512,10.1038/ncomms15332,Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi.,https://pubmed.ncbi.nlm.nih.gov/28541282/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0216,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,18658,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Regulation of allergy with RNA interference.",17573,20121695,,10.1615/critrevimmunol.v29.i6.10,Regulation of allergy with RNA interference.,https://pubmed.ncbi.nlm.nih.gov/20121695/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0217,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,22821,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.",21736,15831707,PMC1895148,10.1182/blood-2004-10-3959,Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.,https://pubmed.ncbi.nlm.nih.gov/15831707/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: delivery/PK source without title-level off-target assay,,,,,,,,TRUE
iv-reject-0218,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,23496,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.",22411,27424208,,10.1016/j.cellsig.2016.07.001,The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.,https://pubmed.ncbi.nlm.nih.gov/27424208/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0219,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,27401,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Long non-coding RNA PVT1 promotes osteosarcoma development by acting as a molecular sponge to regulate miR-195.",26316,27813492,PMC5347719,10.18632/oncotarget.13012,Long non-coding RNA PVT1 promotes osteosarcoma development by acting as a molecular sponge to regulate miR-195.,https://pubmed.ncbi.nlm.nih.gov/27813492/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0220,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,21251,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Overcoming the innate immune response to small interfering RNA.",20166,18230025,,10.1089/hum.2007.179,Overcoming the innate immune response to small interfering RNA.,https://pubmed.ncbi.nlm.nih.gov/18230025/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,"reject reason: review/background article, not primary off-target evidence",,,,,,,,TRUE
iv-reject-0221,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,22982,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo.",21897,15647371,PMC551499,10.1091/mbc.e04-11-1034,"Human splicing factor SF3a, but not SF1, is essential for pre-mRNA splicing in vivo.",https://pubmed.ncbi.nlm.nih.gov/15647371/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0222,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,22661,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Preliminary evaluation of a small interfering RNA molecular probe targeting murine double minute 2 in breast cancer.",21576,35582848,PMC9278711,10.1097/MNM.0000000000001582,Preliminary evaluation of a small interfering RNA molecular probe targeting murine double minute 2 in breast cancer.,https://pubmed.ncbi.nlm.nih.gov/35582848/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0223,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,25538,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Apolipoprotein E but not B is required for the formation of infectious hepatitis C virus particles.",24453,19793818,PMC2786834,10.1128/JVI.01476-09,Apolipoprotein E but not B is required for the formation of infectious hepatitis C virus particles.,https://pubmed.ncbi.nlm.nih.gov/19793818/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0224,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,20381,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Novel small noncoding RNAs in mouse spermatozoa, zygotes and early embryos.",19296,22984523,PMC3440372,10.1371/journal.pone.0044542,"Novel small noncoding RNAs in mouse spermatozoa, zygotes and early embryos.",https://pubmed.ncbi.nlm.nih.gov/22984523/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0225,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,20732,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells.",19647,15235125,PMC490000,10.1073/pnas.0403390101,Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells.,https://pubmed.ncbi.nlm.nih.gov/15235125/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0226,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,18189,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Construction of a CTGF and RFP-coexpressed renal tubular epithelial cell and its application on evaluation of CTGF-specific siRNAs on epithelial-mesenchymal transition.",17104,24703458,,10.1016/j.urology.2013.12.053,Construction of a CTGF and RFP-coexpressed renal tubular epithelial cell and its application on evaluation of CTGF-specific siRNAs on epithelial-mesenchymal transition.,https://pubmed.ncbi.nlm.nih.gov/24703458/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0227,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,24175,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: H3K79 methylation profiles define murine and human MLL-AF4 leukemias.",23090,18977325,PMC2591932manuscript-id: NIHMS78512,10.1016/j.ccr.2008.10.001,H3K79 methylation profiles define murine and human MLL-AF4 leukemias.,https://pubmed.ncbi.nlm.nih.gov/18977325/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0228,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,25859,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer.",24774,32705259,PMC7388243,10.3892/or.2020.7673,Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer.,https://pubmed.ncbi.nlm.nih.gov/32705259/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0229,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,25434,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Long non-coding RNA AFAP1-AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1.",24349,30506548,,10.1111/aji.13074,Long non-coding RNA AFAP1-AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1.,https://pubmed.ncbi.nlm.nih.gov/30506548/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0230,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,29055,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=rnai_screen_specificity; terms=rnai, screen, specificity; source title: Global identification of metal ion transporters in chickpea and delineating the role of CaYSL4 in orchestrating iron content.",27970,39626526,,10.1016/j.plaphy.2024.109292,Global identification of metal ion transporters in chickpea and delineating the role of CaYSL4 in orchestrating iron content.,https://pubmed.ncbi.nlm.nih.gov/39626526/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,rnai;screen;specificity,reject,curator_rejected,reject reason: out-of-scope organism or non-therapeutic oligonucleotide context,,,,,,,,TRUE
iv-reject-0231,candidate_reject_control,candidate_reject_control/offtarget/C/siRNA,offtarget,curation_candidate,19510,C,no,,,siRNA,,"offtarget candidate; derived PubMed query=sirna_rnai_offtarget; terms=sirna, rnai, off-target; source title: Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness.",18425,18305576,,10.1038/gt.2008.15,Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness.,https://pubmed.ncbi.nlm.nih.gov/18305576/,PubMed query-level off-target/specificity candidate; exact source location requires curator check,sirna;rnai;off-target,reject,curator_rejected,reject reason: source text lacks concrete off-target evidence,,,,,,,,TRUE
iv-reject-0232,candidate_reject_control,candidate_reject_control/toxicity/B/ASO,toxicity,curation_candidate,10775,B,no,,,ASO,,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enabling safer, more potent oligonucleotide therapeutics with bottlebrush polymer conjugates.",1923,38145661,PMC10922259manuscript-id: NIHMS1955453,10.1016/j.jconrel.2023.12.035,"Enabling safer, more potent oligonucleotide therapeutics with bottlebrush polymer conjugates.",https://pubmed.ncbi.nlm.nih.gov/38145661/,PubMed abstract sentence 2,toxicity;toxic,reject,curator_rejected,reject reason: safety-like term is part of disease efficacy/cell-killing readout,,,,,,,,TRUE
iv-reject-0233,candidate_reject_control,candidate_reject_control/toxicity/B/ASO,toxicity,curation_candidate,14220,B,no,,,ASO,,toxicity candidate; matched derived terms: renal; source title: Albumin-conjugation enables improved tumor targeting of aptamers via SPECT imaging.,9936,40083648,PMC11904533,10.1016/j.omtn.2025.102483,Albumin-conjugation enables improved tumor targeting of aptamers via SPECT imaging.,https://pubmed.ncbi.nlm.nih.gov/40083648/,PubMed abstract sentence 4,renal,reject,curator_rejected,reject reason: no therapeutic oligonucleotide/siRNA/ASO safety modality supported by source context,,,,,,,,TRUE
iv-reject-0234,candidate_reject_control,candidate_reject_control/toxicity/B/ASO,toxicity,curation_candidate,13313,B,no,,,ASO,,toxicity candidate; matched derived terms: adverse; source title: The Heart's Small Molecules: The Importance of MicroRNAs in Cardiovascular Health.,7833,41226851,PMC12608254,10.3390/jcm14217454,The Heart's Small Molecules: The Importance of MicroRNAs in Cardiovascular Health.,https://pubmed.ncbi.nlm.nih.gov/41226851/,PubMed abstract sentence 9,adverse,reject,curator_rejected,"reject reason: review/background article, not primary release evidence",,,,,,,,TRUE
iv-reject-0235,candidate_reject_control,candidate_reject_control/toxicity/B/ASO,toxicity,curation_candidate,10928,B,no,,,ASO,,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Phosphorothioated antisense oligodeoxynucleotide suppressing interleukin-10 is a safe and potent vaccine adjuvant.",2370,31164303,,10.1016/j.vaccine.2019.05.076,Phosphorothioated antisense oligodeoxynucleotide suppressing interleukin-10 is a safe and potent vaccine adjuvant.,https://pubmed.ncbi.nlm.nih.gov/31164303/,PubMed abstract sentence 3,toxicity;toxic,reject,curator_rejected,reject reason: safety endpoint is too generic or unsupported,,,,,,,,TRUE
iv-reject-0236,candidate_reject_control,candidate_reject_control/toxicity/B/ASO,toxicity,curation_candidate,590,B,no,,,ASO,,toxicity candidate from queue only; source title: Quantitative analysis of oligonucleotide delivery into isolated mitochondria: a proof-of-concept method.,1391,41884956,,10.1080/07366205.2026.2635461,Quantitative analysis of oligonucleotide delivery into isolated mitochondria: a proof-of-concept method.,https://pubmed.ncbi.nlm.nih.gov/41884956/,source title,,reject,curator_rejected,reject reason: source location does not support primary oligonucleotide toxicity evidence,,,,,,,,TRUE
iv-reject-0237,candidate_reject_control,candidate_reject_control/toxicity/B/ASO,toxicity,curation_candidate,14922,B,no,,,ASO,,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A novel ratiometric electrochemical aptasensor based on M-shaped functional DNA complexes for simultaneous detection of trace lead and mercury ions in series aquatic edible vegetables.",11681,38070266,,10.1016/j.jhazmat.2023.133169,A novel ratiometric electrochemical aptasensor based on M-shaped functional DNA complexes for simultaneous detection of trace lead and mercury ions in series aquatic edible vegetables.,https://pubmed.ncbi.nlm.nih.gov/38070266/,PubMed abstract sentence 1,toxicity;toxic,reject,curator_rejected,reject reason: non-therapeutic oligonucleotide method/tool source,,,,,,,,TRUE
iv-reject-0238,candidate_reject_control,candidate_reject_control/toxicity/B/ASO,toxicity,curation_candidate,10688,B,no,,,ASO,,toxicity candidate; matched derived terms: safety; source title: Update on Gene Therapy Clinical Trials for Eye Diseases.,1807,40965251,PMC13089423embargo-date: 2026/10/08,10.1177/10430342251379824,Update on Gene Therapy Clinical Trials for Eye Diseases.,https://pubmed.ncbi.nlm.nih.gov/40965251/,PubMed abstract sentence 6,safety,reject,curator_rejected,"reject reason: review/background article, not primary release evidence",,,,,,,,TRUE
iv-reject-0239,candidate_reject_control,candidate_reject_control/toxicity/B/ASO,toxicity,curation_candidate,12290,B,no,,,ASO,,"toxicity candidate; matched derived terms: risk; source title: Aptamers as therapeutic tool against oxidative and inflammatory intermediaries of astrocytes in neurological disorders: Current paradigms, perspective, future directions and challenges.",5469,41933686,,10.1016/j.biochi.2026.03.015,"Aptamers as therapeutic tool against oxidative and inflammatory intermediaries of astrocytes in neurological disorders: Current paradigms, perspective, future directions and challenges.",https://pubmed.ncbi.nlm.nih.gov/41933686/,PubMed abstract sentence 5,risk,reject,curator_rejected,"reject reason: review/background article, not primary release evidence",,,,,,,,TRUE
iv-reject-0240,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,886,B,no,,,ASO/siRNA,,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Perfluorooctane Sulfonamide Induced Autotoxic Effects on the Zebrafish Immune System.",1576,38976350,,10.1021/acs.est.4c01153,Perfluorooctane Sulfonamide Induced Autotoxic Effects on the Zebrafish Immune System.,https://pubmed.ncbi.nlm.nih.gov/38976350/,PubMed abstract sentence 3,toxicity;toxic,reject,curator_rejected,reject reason: no ASO/siRNA/oligonucleotide molecule support in source text,,,,,,,,TRUE
iv-reject-0241,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,2669,B,no,,,ASO/siRNA,,toxicity candidate; matched derived terms: renal; source title: Carnosine alleviates high glucose-induced renal tubular cell pyroptosis by activating the AMPK/SIRT3/SOD2 pathway.,2876,41796057,,10.1080/10715762.2026.2640501,Carnosine alleviates high glucose-induced renal tubular cell pyroptosis by activating the AMPK/SIRT3/SOD2 pathway.,https://pubmed.ncbi.nlm.nih.gov/41796057/,PubMed abstract sentence 13,renal,reject,curator_rejected,"reject reason: cytotoxicity appears to be efficacy/cancer-killing readout, not safety evidence",,,,,,,,TRUE
iv-reject-0242,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,11144,B,no,,,ASO/siRNA,,toxicity candidate; matched derived terms: adverse; source title: Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice.,3180,42105437,PMC13185993,10.1016/j.neurot.2026.e00917,Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice.,https://pubmed.ncbi.nlm.nih.gov/42105437/,PubMed abstract sentence 10,adverse,reject,curator_rejected,"reject reason: mRNA-only source, not ASO/siRNA/oligonucleotide safety or off-target evidence",,,,,,,,TRUE
iv-reject-0243,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,584,B,no,,,ASO/siRNA,,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Baiting-enhanced extravasation of lipid nanoparticles for targeted co-delivery of decitabine and siTNF-α to the bone marrow niche in leukemia therapy.",1388,41905408,,10.1016/j.jconrel.2026.114874,Baiting-enhanced extravasation of lipid nanoparticles for targeted co-delivery of decitabine and siTNF-α to the bone marrow niche in leukemia therapy.,https://pubmed.ncbi.nlm.nih.gov/41905408/,PubMed abstract sentence 5,toxicity;toxic,reject,curator_rejected,reject reason: source text is background/narrative rather than primary result,,,,,,,,TRUE
iv-reject-0244,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,8824,B,no,,,ASO/siRNA,,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells.",12100,36087010,,10.1093/toxsci/kfac091,"Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells.",https://pubmed.ncbi.nlm.nih.gov/36087010/,PubMed abstract sentence 2,toxicity;toxic,reject,curator_rejected,reject reason: toxicity belongs to disease/toxin model where oligo is a perturbation tool,,,,,,,,TRUE
iv-reject-0245,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,6138,B,no,,,ASO/siRNA,,toxicity candidate from queue only; source title: The innate immune IMD pathway is a key regulator of gut microbiome and metabolic homeostasis in the black tiger shrimp (Penaeus monodon).,7546,41401155,PMC12707661,10.1371/journal.pone.0338796,The innate immune IMD pathway is a key regulator of gut microbiome and metabolic homeostasis in the black tiger shrimp (Penaeus monodon).,https://pubmed.ncbi.nlm.nih.gov/41401155/,source title,,reject,curator_rejected,reject reason: no primary safety/toxicity endpoint in verified source text,,,,,,,,TRUE
iv-reject-0246,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,9890,B,no,,,ASO/siRNA,,toxicity candidate from queue only; source title: SAA1 as a key mediator of immune inflammatory pathways in fungal keratitis through FOXO3a phosphorylation regulation.,13324,40020519,,10.1016/j.cyto.2025.156898,SAA1 as a key mediator of immune inflammatory pathways in fungal keratitis through FOXO3a phosphorylation regulation.,https://pubmed.ncbi.nlm.nih.gov/40020519/,source title,,reject,curator_rejected,reject reason: out-of-scope non-therapeutic or non-human oligonucleotide context,,,,,,,,TRUE
iv-reject-0247,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,7800,B,no,,,ASO/siRNA,,toxicity candidate from queue only; source title: Nanocarrier-Mediated RNA Delivery Platform as a Frontier Strategy for Hepatic Disease Treatment: Challenges and Opportunities.,10334,39723654,,10.1002/adhm.202402933,Nanocarrier-Mediated RNA Delivery Platform as a Frontier Strategy for Hepatic Disease Treatment: Challenges and Opportunities.,https://pubmed.ncbi.nlm.nih.gov/39723654/,source title,,reject,curator_rejected,reject reason: source location does not support primary oligonucleotide toxicity evidence,,,,,,,,TRUE
iv-reject-0248,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,2707,B,no,,,ASO/siRNA,,toxicity candidate; matched derived terms: renal; source title: Fu Zheng Xiao Yu San Jie Decoction affects the proliferation of renal cell carcinoma via regulating E2F5 gene.,2907,41522321,PMC12779431,10.21037/tau-2025-aw-739,Fu Zheng Xiao Yu San Jie Decoction affects the proliferation of renal cell carcinoma via regulating E2F5 gene.,https://pubmed.ncbi.nlm.nih.gov/41522321/,PubMed abstract sentence 1,renal,reject,curator_rejected,reject reason: no primary ASO/siRNA/oligonucleotide safety evidence at source anchor,,,,,,,,TRUE
iv-reject-0249,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,1667,B,no,,,ASO/siRNA,,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synergistic RNA particles for spontaneous and specific cancer targeting but low toxicity due to motility and deformation.",2174,40196906,PMC12233875,10.1080/17435889.2025.2488727,Synergistic RNA particles for spontaneous and specific cancer targeting but low toxicity due to motility and deformation.,https://pubmed.ncbi.nlm.nih.gov/40196906/,PubMed title,toxicity;toxic,reject,curator_rejected,reject reason: source location unsupported; no full-text anchor or PubMed abstract evidence,,,,,,,,TRUE
iv-reject-0250,candidate_reject_control,candidate_reject_control/toxicity/B/ASO/siRNA,toxicity,curation_candidate,6079,B,no,,,ASO/siRNA,,toxicity candidate from queue only; source title: Hypoxia-induced immunosuppression in uveal melanoma is mediated by CD63(+) exosomes delivering lactate to reprogram immune cells.,7416,41573746,PMC12819323,10.3389/fmolb.2025.1743009,Hypoxia-induced immunosuppression in uveal melanoma is mediated by CD63(+) exosomes delivering lactate to reprogram immune cells.,https://pubmed.ncbi.nlm.nih.gov/41573746/,source title,,reject,curator_rejected,reject reason: source text is background/narrative rather than primary result,,,,,,,,TRUE