id,queue_id,pmid,doi,evidence_domain,candidate_modality,source_location,matched_terms,candidate_signal,suggested_evidence_grade,confidence_label,validation_status,curator_decision,redistribution_level,source_title
2,6,41078095,10.1002/cbic.202500584,chemistry,ASO,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Toxicity of Antisense Oligonucleotides is Determined by the Synergistic Interplay of Chemical Modifications and Nucleotide Sequences",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Toxicity of Antisense Oligonucleotides is Determined by the Synergistic Interplay of Chemical Modifications and Nucleotide Sequences
3,7,41078095,10.1002/cbic.202500584,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Toxicity of Antisense Oligonucleotides is Determined by the Synergistic Interplay of Chemical Modifications and Nucleotide Sequences",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Toxicity of Antisense Oligonucleotides is Determined by the Synergistic Interplay of Chemical Modifications and Nucleotide Sequences
6,12,39912803,10.1089/nat.2024.0072,offtarget,ASO,PubMed abstract sentence 1,off-target;hybridization;unintended,"offtarget candidate; matched derived terms: off-target, hybridization, unintended; source title: Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations.
7,13,39912803,10.1089/nat.2024.0072,benchmark,ASO,PubMed abstract sentence 7,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations.
8,16,38192001,10.1093/bioinformatics/btae011,offtarget,siRNA,PubMed abstract sentence 2,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: SeedMatchR: identify off-target effects mediated by siRNA seed regions in RNA-seq experiments.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SeedMatchR: identify off-target effects mediated by siRNA seed regions in RNA-seq experiments.
10,20,41760661,10.1038/s41467-026-69980-2,chemistry,ASO,PubMed abstract sentence 1,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides.
11,21,41760661,10.1038/s41467-026-69980-2,toxicity,ASO,PubMed abstract sentence 6,toxic;dna damage,"toxicity candidate; matched derived terms: toxic, dna damage; source title: Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides.
13,25,40877521,10.1007/978-1-0716-4742-4_24,chemistry,siRNA,PubMed abstract sentence 7,chemical;modification;modified,"chemistry candidate; matched derived terms: chemical, modification, modified; source title: siRMSD: A Structural Parameter to Reduce Sequence-Dependent Off-Target Effects for siRNA Design with Chemical Modifications.",B,high_candidate,curator_verified,accept,derived_annotations_only,siRMSD: A Structural Parameter to Reduce Sequence-Dependent Off-Target Effects for siRNA Design with Chemical Modifications.
14,26,40877521,10.1007/978-1-0716-4742-4_24,offtarget,siRNA,PubMed abstract sentence 4,off-target;seed;unintended,"offtarget candidate; matched derived terms: off-target, seed, unintended; source title: siRMSD: A Structural Parameter to Reduce Sequence-Dependent Off-Target Effects for siRNA Design with Chemical Modifications.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,siRMSD: A Structural Parameter to Reduce Sequence-Dependent Off-Target Effects for siRNA Design with Chemical Modifications.
16,30,37589246,10.1002/jcph.2337,chemistry,siRNA,PubMed abstract sentence 5,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Pharmacokinetics and Pharmacodynamics of GalNAc-Conjugated siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pharmacokinetics and Pharmacodynamics of GalNAc-Conjugated siRNAs.
17,31,37589246,10.1002/jcph.2337,delivery,siRNA,PubMed abstract sentence 5,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Pharmacokinetics and Pharmacodynamics of GalNAc-Conjugated siRNAs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pharmacokinetics and Pharmacodynamics of GalNAc-Conjugated siRNAs.
18,34,38204162,10.1016/j.ymthe.2024.01.005,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: The landscape of nanoparticle-based siRNA delivery and therapeutic development.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The landscape of nanoparticle-based siRNA delivery and therapeutic development.
19,35,38204162,10.1016/j.ymthe.2024.01.005,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: The landscape of nanoparticle-based siRNA delivery and therapeutic development.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The landscape of nanoparticle-based siRNA delivery and therapeutic development.
20,38,38334488,10.1097/MED.0000000000000857,delivery,siRNA,PubMed abstract sentence 8,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: APOC3 siRNA and ASO therapy for dyslipidemia.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,APOC3 siRNA and ASO therapy for dyslipidemia.
21,41,38362953,10.1002/cpt.3204,toxicity,ASO,PubMed abstract sentence 12,safety;risk;proarrhythmic,"toxicity candidate; matched derived terms: safety, risk, proarrhythmic; source title: Scientific Review of the Proarrhythmic Risks of Oligonucleotide Therapeutics: Are Dedicated ICH S7B/E14 Studies Needed for Low-Risk Modalities?",B,high_candidate,curator_rejected,reject,derived_annotations_only,Scientific Review of the Proarrhythmic Risks of Oligonucleotide Therapeutics: Are Dedicated ICH S7B/E14 Studies Needed for Low-Risk Modalities?
23,47,40646322,10.1038/s41591-025-03784-7,assay,ASO,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trial.
24,52,40134378,10.1089/nat.2024.0090,chemistry,siRNA,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates.
25,53,40134378,10.1089/nat.2024.0090,delivery,siRNA,PubMed abstract sentence 1,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates.
26,54,40134378,10.1089/nat.2024.0090,offtarget,siRNA,PubMed abstract sentence 2,off-target;seed;silencing,"offtarget candidate; matched derived terms: off-target, seed, silencing; source title: Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates.
28,58,40721084,10.1016/j.slasd.2025.100254,assay,ASO,PubMed abstract sentence 8,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Off-target effects of oligonucleotides and approaches of preclinical assessments.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Off-target effects of oligonucleotides and approaches of preclinical assessments.
29,59,40721084,10.1016/j.slasd.2025.100254,offtarget,ASO,PubMed abstract sentence 4,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: Off-target effects of oligonucleotides and approaches of preclinical assessments.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Off-target effects of oligonucleotides and approaches of preclinical assessments.
31,67,39829133,10.1002/brb3.70221,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;safety;renal,"toxicity candidate; matched derived terms: toxicity, toxic, safety, renal; source title: Safety and Efficacy of Nusinersen Focusing on Renal and Hematological Parameters in Spinal Muscular Atrophy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Safety and Efficacy of Nusinersen Focusing on Renal and Hematological Parameters in Spinal Muscular Atrophy.
32,70,38954918,10.1016/j.bmc.2024.117825,chemistry,siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Advances in structural-guided modifications of siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in structural-guided modifications of siRNA.
33,73,40877500,10.1007/978-1-0716-4742-4_3,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Chemical Modifications in Nucleic Acid Therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical Modifications in Nucleic Acid Therapeutics.
38,84,40098305,10.1111/cas.70024,chemistry,ASO,PubMed abstract sentence 5,modified;amna,"chemistry candidate; matched derived terms: modified, amna; source title: AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds.
42,96,39214039,10.1016/j.hrtlng.2024.08.015,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic;adverse;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, adverse, hepatotoxicity; source title: Safety and effectiveness of interference RNA (RNAi) based therapeutics in cardiac failure: A systematic review.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety and effectiveness of interference RNA (RNAi) based therapeutics in cardiac failure: A systematic review.
43,105,41467114,10.1016/j.omtn.2025.102692,chemistry,ASO,PubMed abstract sentence 5,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Unraveling and controlling late-onset neurotoxicity of antisense oligonucleotides through strategic chemical modifications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unraveling and controlling late-onset neurotoxicity of antisense oligonucleotides through strategic chemical modifications.
44,106,41467114,10.1016/j.omtn.2025.102692,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Unraveling and controlling late-onset neurotoxicity of antisense oligonucleotides through strategic chemical modifications.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Unraveling and controlling late-onset neurotoxicity of antisense oligonucleotides through strategic chemical modifications.
46,110,41500580,10.2131/jts.51.75,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic;adverse;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, adverse, hepatotoxicity; source title: Predicting nucleic acid drug-induced nephrotoxicity using a 3D human renal proximal tubule spheroid model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Predicting nucleic acid drug-induced nephrotoxicity using a 3D human renal proximal tubule spheroid model.
50,116,41021771,10.1111/cts.70344,toxicity,ASO,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Pharmacokinetics and Safety of Pelacarsen, a GalNAc(3)-Conjugated Antisense Oligonucleotide Targeting Apo(a), in Participants With Mild Hepatic Impairment.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Pharmacokinetics and Safety of Pelacarsen, a GalNAc(3)-Conjugated Antisense Oligonucleotide Targeting Apo(a), in Participants With Mild Hepatic Impairment."
51,119,41994868,10.1093/nar/gkag345,chemistry,siRNA,PubMed abstract sentence 2,modified;galnac;lna;conjugate,"chemistry candidate; matched derived terms: modified, galnac, lna, conjugate; source title: Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.
52,120,41994868,10.1093/nar/gkag345,offtarget,siRNA,PubMed abstract sentence 5,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.
56,128,42172871,10.1016/j.dmd.2026.100304,assay,ASO,PubMed abstract sentence 8,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Peptide-mediated delivery of an α-synuclein-targeting antisense oligonucleotide: Pharmacokinetics, safety, and central nervous system efficacy in a synucleinopathy model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Peptide-mediated delivery of an α-synuclein-targeting antisense oligonucleotide: Pharmacokinetics, safety, and central nervous system efficacy in a synucleinopathy model."
57,129,42172871,10.1016/j.dmd.2026.100304,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Peptide-mediated delivery of an α-synuclein-targeting antisense oligonucleotide: Pharmacokinetics, safety, and central nervous system efficacy in a synucleinopathy model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Peptide-mediated delivery of an α-synuclein-targeting antisense oligonucleotide: Pharmacokinetics, safety, and central nervous system efficacy in a synucleinopathy model."
60,136,41918821,10.1093/narmme/ugag016,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Integrating transcriptomics and proteomics to assess antisense oligonucleotide safety and efficacy: a time-resolved approach.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Integrating transcriptomics and proteomics to assess antisense oligonucleotide safety and efficacy: a time-resolved approach.
67,153,41186228,10.1128/aac.00679-25,toxicity,ASO,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Safety, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide RO7239958 in healthy volunteers and adults with chronic hepatitis B infection.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide RO7239958 in healthy volunteers and adults with chronic hepatitis B infection."
68,156,39850319,10.1016/j.omtn.2024.102387,chemistry,ASO,PubMed abstract sentence 6,modification;modified;phosphorothioate;2'-moe,"chemistry candidate; matched derived terms: modification, modified, phosphorothioate, 2'-moe; source title: In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney.
70,160,42070763,10.1016/j.ejphar.2026.178917,chemistry,siRNA,PubMed abstract sentence 4,modified;galnac;lna,"chemistry candidate; matched derived terms: modified, galnac, lna; source title: Targeted knockdown of hepatic XDH via GalNAc-siRNA alleviates hyperuricaemia and renal injury in UOX(-/-) mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted knockdown of hepatic XDH via GalNAc-siRNA alleviates hyperuricaemia and renal injury in UOX(-/-) mice.
78,174,40685980,10.1177/21593337251361396,chemistry,ASO,PubMed abstract sentence 6,modification;phosphorothioate;2'-moe,"chemistry candidate; matched derived terms: modification, phosphorothioate, 2'-moe; source title: Characterizing Antibodies Targeting Antisense Oligonucleotide Phosphorothioate and 2'-O-Methoxyethyl Modifications for Intracellular Trafficking and Biodistribution Studies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Characterizing Antibodies Targeting Antisense Oligonucleotide Phosphorothioate and 2'-O-Methoxyethyl Modifications for Intracellular Trafficking and Biodistribution Studies.
79,177,38660533,10.1039/d4ra01925c,chemistry,ASO,PubMed abstract sentence 1,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Inhibition of survivin by 2'-O-methyl phosphorothioate-modified steric-blocking antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhibition of survivin by 2'-O-methyl phosphorothioate-modified steric-blocking antisense oligonucleotides.
83,185,40899091,10.1177/21593337251375804,toxicity,siRNA,PubMed abstract sentence 5,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Use of a Transgenic Human PNPLA3(I148M) Knock-in Mouse for Translational Safety Evaluations of siRNA Therapeutics.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Use of a Transgenic Human PNPLA3(I148M) Knock-in Mouse for Translational Safety Evaluations of siRNA Therapeutics.
84,188,40151235,10.1021/jacsau.5c00012,chemistry,siRNA,PubMed abstract sentence 3,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: General Platform for Efficient and Modular Assembly of GalNAc-siRNA Conjugates via Primary Amines and o-Nitrobenzyl Alcohol Cyclization Photoclick Chemistry Enabling Rapid Access to Therapeutic Oligonucleotides.",B,high_candidate,curator_verified,accept,derived_annotations_only,General Platform for Efficient and Modular Assembly of GalNAc-siRNA Conjugates via Primary Amines and o-Nitrobenzyl Alcohol Cyclization Photoclick Chemistry Enabling Rapid Access to Therapeutic Oligonucleotides.
89,199,42169510,10.1093/eurjpc/zwag273,toxicity,ASO/siRNA,PubMed abstract sentence 6,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Efficacy and Safety of Oral PCSK9 Inhibitors: Insights from a Meta-analysis of RCTS.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and Safety of Oral PCSK9 Inhibitors: Insights from a Meta-analysis of RCTS.
90,202,42149053,10.1039/d6tb00003g,chemistry,siRNA,PubMed abstract sentence 5,modified;galnac;lna,"chemistry candidate; matched derived terms: modified, galnac, lna; source title: GalNAc-modified five-component lipid nanoparticles for liver-targeted delivery of p65 siRNA to alleviate cytokine storm in liver injury via NF-κB targeting.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-modified five-component lipid nanoparticles for liver-targeted delivery of p65 siRNA to alleviate cytokine storm in liver injury via NF-κB targeting.
91,203,42149053,10.1039/d6tb00003g,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: GalNAc-modified five-component lipid nanoparticles for liver-targeted delivery of p65 siRNA to alleviate cytokine storm in liver injury via NF-κB targeting.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-modified five-component lipid nanoparticles for liver-targeted delivery of p65 siRNA to alleviate cytokine storm in liver injury via NF-κB targeting.
92,204,42149053,10.1039/d6tb00003g,toxicity,siRNA,PubMed abstract sentence 11,safety;hematological,"toxicity candidate; matched derived terms: safety, hematological; source title: GalNAc-modified five-component lipid nanoparticles for liver-targeted delivery of p65 siRNA to alleviate cytokine storm in liver injury via NF-κB targeting.",B,high_candidate,curator_rejected,reject,derived_annotations_only,GalNAc-modified five-component lipid nanoparticles for liver-targeted delivery of p65 siRNA to alleviate cytokine storm in liver injury via NF-κB targeting.
93,207,42112102,10.1016/j.omtn.2026.102936,chemistry,siRNA,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: A computational model-powered platform to inform the development of GalNAc-conjugated siRNA therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A computational model-powered platform to inform the development of GalNAc-conjugated siRNA therapeutics.
94,208,42112102,10.1016/j.omtn.2026.102936,delivery,siRNA,PubMed abstract sentence 1,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: A computational model-powered platform to inform the development of GalNAc-conjugated siRNA therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A computational model-powered platform to inform the development of GalNAc-conjugated siRNA therapeutics.
100,224,41949334,10.1111/cts.70536,chemistry,siRNA,PubMed abstract sentence 4,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.
101,225,41949334,10.1111/cts.70536,delivery,siRNA,PubMed abstract sentence 4,galnac;conjugated;uptake,"delivery candidate; matched derived terms: galnac, conjugated, uptake; source title: A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.
102,226,41949334,10.1111/cts.70536,assay,siRNA,PubMed abstract sentence 11,screen;preclinical;model,"assay candidate; matched derived terms: screen, preclinical, model; source title: A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.
103,227,41949334,10.1111/cts.70536,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.
110,238,41887560,10.1016/j.amjcard.2026.03.052,toxicity,ASO/siRNA,PubMed abstract sentence 5,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Efficacy and Safety of Olezarsen for the Management of Dyslipidemia: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and Safety of Olezarsen for the Management of Dyslipidemia: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.
113,247,41813449,10.1016/j.nmd.2025.106256,toxicity,ASO/siRNA,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: A prospective, multi-center, observational study of the safety, tolerability and effectiveness of Nusinersen in adult patients with spinal muscular atrophy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"A prospective, multi-center, observational study of the safety, tolerability and effectiveness of Nusinersen in adult patients with spinal muscular atrophy."
114,250,41754970,10.3390/pharmaceutics18020228,delivery,ASO,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Unconventional Lysine-Type Lipid Assemblies Enable Efficient Antisense Oligonucleotide Delivery with Distinct Structural Features.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unconventional Lysine-Type Lipid Assemblies Enable Efficient Antisense Oligonucleotide Delivery with Distinct Structural Features.
115,251,41754970,10.3390/pharmaceutics18020228,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Unconventional Lysine-Type Lipid Assemblies Enable Efficient Antisense Oligonucleotide Delivery with Distinct Structural Features.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Unconventional Lysine-Type Lipid Assemblies Enable Efficient Antisense Oligonucleotide Delivery with Distinct Structural Features.
118,262,41541269,10.1016/j.omtn.2025.102801,chemistry,siRNA,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Ribofuranose-based GalNAc-conjugated siRNA enhances the liver-targeted delivery and elicits robust RNAi-mediated gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ribofuranose-based GalNAc-conjugated siRNA enhances the liver-targeted delivery and elicits robust RNAi-mediated gene silencing.
119,263,41541269,10.1016/j.omtn.2025.102801,delivery,siRNA,PubMed abstract sentence 2,delivery;galnac;conjugated,"delivery candidate; matched derived terms: delivery, galnac, conjugated; source title: Ribofuranose-based GalNAc-conjugated siRNA enhances the liver-targeted delivery and elicits robust RNAi-mediated gene silencing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ribofuranose-based GalNAc-conjugated siRNA enhances the liver-targeted delivery and elicits robust RNAi-mediated gene silencing.
122,270,41388232,10.1007/s40262-025-01606-0,chemistry,siRNA,PubMed abstract sentence 1,chemical;galnac;lna;conjugate,"chemistry candidate; matched derived terms: chemical, galnac, lna, conjugate; source title: Platform Assessment of Concentration-QTc Relationship Across GalNAc-siRNA Molecules.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Platform Assessment of Concentration-QTc Relationship Across GalNAc-siRNA Molecules.
123,271,41388232,10.1007/s40262-025-01606-0,delivery,siRNA,PubMed abstract sentence 1,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Platform Assessment of Concentration-QTc Relationship Across GalNAc-siRNA Molecules.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Platform Assessment of Concentration-QTc Relationship Across GalNAc-siRNA Molecules.
124,274,41314857,10.1177/21593337251399181,chemistry,ASO,PubMed abstract sentence 2,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Unveiling Liver Micro-Distribution: NanoSIMS Imaging Reveals Critical Intracellular Distribution of Chemically Modified Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unveiling Liver Micro-Distribution: NanoSIMS Imaging Reveals Critical Intracellular Distribution of Chemically Modified Antisense Oligonucleotides.
125,275,41314857,10.1177/21593337251399181,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Unveiling Liver Micro-Distribution: NanoSIMS Imaging Reveals Critical Intracellular Distribution of Chemically Modified Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Unveiling Liver Micro-Distribution: NanoSIMS Imaging Reveals Critical Intracellular Distribution of Chemically Modified Antisense Oligonucleotides.
128,284,41085094,10.1002/cpdd.1615,toxicity,ASO/siRNA,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: A Phase 1, Randomized, Open-Label, Parallel Group Study to Evaluate the Relative Bioavailability and Safety of Subcutaneous Bepirovirsen when Delivered from a Vial or Prefilled Syringe Fitted with a Safety Syringe Device in Healthy Adult Participants.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"A Phase 1, Randomized, Open-Label, Parallel Group Study to Evaluate the Relative Bioavailability and Safety of Subcutaneous Bepirovirsen when Delivered from a Vial or Prefilled Syringe Fitted with a Safety Syringe Device in Healthy Adult Participants."
129,289,41457341,10.1177/01926233251404016,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Proceedings of the 2024 Classic Examples in Toxicologic Pathology XXXI.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Proceedings of the 2024 Classic Examples in Toxicologic Pathology XXXI.
136,308,41012491,10.3390/pharmaceutics17091154,chemistry,siRNA,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.
137,309,41012491,10.3390/pharmaceutics17091154,delivery,siRNA,PubMed abstract sentence 1,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.",C,high_candidate,curator_rejected,reject,derived_annotations_only,Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.
138,310,41012491,10.3390/pharmaceutics17091154,assay,siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.
140,314,40962198,10.1016/j.ymeth.2025.09.005,chemistry,ASO,PubMed abstract sentence 2,phosphorothioate;2'-o,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o; source title: Advancing antisense oligonucleotide delivery through click chemistry based chemical conjugation with designed short non-cationic peptides for Duchenne muscular dystrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advancing antisense oligonucleotide delivery through click chemistry based chemical conjugation with designed short non-cationic peptides for Duchenne muscular dystrophy.
141,315,40962198,10.1016/j.ymeth.2025.09.005,delivery,ASO,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Advancing antisense oligonucleotide delivery through click chemistry based chemical conjugation with designed short non-cationic peptides for Duchenne muscular dystrophy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advancing antisense oligonucleotide delivery through click chemistry based chemical conjugation with designed short non-cationic peptides for Duchenne muscular dystrophy.
143,321,40418024,10.1021/acs.analchem.5c01587,chemistry,siRNA,PubMed abstract sentence 3,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Differential Protein Precipitation-Based GalNAc-siRNA Sample Preparation with LC/MS Method Development Workflow in Plasma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Differential Protein Precipitation-Based GalNAc-siRNA Sample Preparation with LC/MS Method Development Workflow in Plasma.
145,325,40317426,10.1007/s40262-025-01513-4,chemistry,siRNA,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Prediction of Interspecies Translation for Targeting Delivery Coefficients of GalNAc-siRNA Silencing Apolipoprotein C-III Using a Mechanistic Minimal Physiologically Based Pharmacokinetic/Pharmacodynamic Model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prediction of Interspecies Translation for Targeting Delivery Coefficients of GalNAc-siRNA Silencing Apolipoprotein C-III Using a Mechanistic Minimal Physiologically Based Pharmacokinetic/Pharmacodynamic Model.
146,326,40317426,10.1007/s40262-025-01513-4,delivery,siRNA,PubMed abstract sentence 7,delivery;galnac;uptake,"delivery candidate; matched derived terms: delivery, galnac, uptake; source title: Prediction of Interspecies Translation for Targeting Delivery Coefficients of GalNAc-siRNA Silencing Apolipoprotein C-III Using a Mechanistic Minimal Physiologically Based Pharmacokinetic/Pharmacodynamic Model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prediction of Interspecies Translation for Targeting Delivery Coefficients of GalNAc-siRNA Silencing Apolipoprotein C-III Using a Mechanistic Minimal Physiologically Based Pharmacokinetic/Pharmacodynamic Model.
150,330,40317426,10.1007/s40262-025-01513-4,benchmark,siRNA,PubMed abstract sentence 5,model;dataset,"benchmark candidate; matched derived terms: model, dataset; source title: Prediction of Interspecies Translation for Targeting Delivery Coefficients of GalNAc-siRNA Silencing Apolipoprotein C-III Using a Mechanistic Minimal Physiologically Based Pharmacokinetic/Pharmacodynamic Model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prediction of Interspecies Translation for Targeting Delivery Coefficients of GalNAc-siRNA Silencing Apolipoprotein C-III Using a Mechanistic Minimal Physiologically Based Pharmacokinetic/Pharmacodynamic Model.
156,344,39861717,10.3390/pharmaceutics17010069,delivery,siRNA,PubMed abstract sentence 2,galnac;uptake,"delivery candidate; matched derived terms: galnac, uptake; source title: Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs.
159,351,39911828,10.3389/fphar.2024.1481937,chemistry,ASO,PubMed abstract sentence 2,modified;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: modified, phosphorothioate, 2'-o; source title: Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method.
160,354,39168524,10.1124/dmd.124.001805,chemistry,siRNA,PubMed abstract sentence 2,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Nonclinical Pharmacokinetics Study of OLX702A-075-16, N-Acetylgalactosamine Conjugated Asymmetric Small Interfering RNA (GalNAc-asiRNA).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Nonclinical Pharmacokinetics Study of OLX702A-075-16, N-Acetylgalactosamine Conjugated Asymmetric Small Interfering RNA (GalNAc-asiRNA)."
161,355,39168524,10.1124/dmd.124.001805,delivery,siRNA,PubMed abstract sentence 2,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Nonclinical Pharmacokinetics Study of OLX702A-075-16, N-Acetylgalactosamine Conjugated Asymmetric Small Interfering RNA (GalNAc-asiRNA).",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Nonclinical Pharmacokinetics Study of OLX702A-075-16, N-Acetylgalactosamine Conjugated Asymmetric Small Interfering RNA (GalNAc-asiRNA)."
163,359,39128879,10.1002/anie.202409440,chemistry,ASO,PubMed abstract sentence 4,chemical;modification;phosphorothioate;conjugate,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate, conjugate; source title: Accessing Therapeutically-Relevant Multifunctional Antisense Oligonucleotide Conjugates Using Native Chemical Ligation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Accessing Therapeutically-Relevant Multifunctional Antisense Oligonucleotide Conjugates Using Native Chemical Ligation.
166,368,38981217,10.1016/j.bmc.2024.117814,chemistry,ASO,PubMed abstract sentence 3,chemical;modified;conjugate,"chemistry candidate; matched derived terms: chemical, modified, conjugate; source title: In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity.
169,373,38841435,10.1016/j.heliyon.2024.e31924,chemistry,siRNA,PubMed abstract sentence 7,galnac;lna,"chemistry candidate; matched derived terms: galnac, lna; source title: Analysis of the pharmacokinetics and efficacy of RBD1016 - A GalNAc-siRNA targeting Hepatitis B Virus X gene using semi-mechanistic PK/PD model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Analysis of the pharmacokinetics and efficacy of RBD1016 - A GalNAc-siRNA targeting Hepatitis B Virus X gene using semi-mechanistic PK/PD model.
170,374,38841435,10.1016/j.heliyon.2024.e31924,delivery,siRNA,PubMed abstract sentence 2,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Analysis of the pharmacokinetics and efficacy of RBD1016 - A GalNAc-siRNA targeting Hepatitis B Virus X gene using semi-mechanistic PK/PD model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Analysis of the pharmacokinetics and efficacy of RBD1016 - A GalNAc-siRNA targeting Hepatitis B Virus X gene using semi-mechanistic PK/PD model.
173,379,38773176,10.1038/s41598-024-61666-3,chemistry,ASO,PubMed abstract sentence 4,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation.
176,386,38742636,10.1093/nar/gkae350,chemistry,siRNA,PubMed abstract sentence 5,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.
177,387,38742636,10.1093/nar/gkae350,delivery,siRNA,PubMed abstract sentence 8,delivery;galnac;conjugated,"delivery candidate; matched derived terms: delivery, galnac, conjugated; source title: Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.
181,395,38155279,10.1007/s11427-023-2434-8,chemistry,siRNA,PubMed abstract sentence 8,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway.
182,396,38155279,10.1007/s11427-023-2434-8,delivery,siRNA,PubMed abstract sentence 8,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway.
183,399,37980543,10.1016/j.ymthe.2023.11.012,chemistry,siRNA,PubMed abstract sentence 6,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: GalNAc-conjugated siRNA targeting the DNAJB1-PRKACA fusion junction in fibrolamellar hepatocellular carcinoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-conjugated siRNA targeting the DNAJB1-PRKACA fusion junction in fibrolamellar hepatocellular carcinoma.
184,400,37980543,10.1016/j.ymthe.2023.11.012,delivery,siRNA,PubMed abstract sentence 6,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: GalNAc-conjugated siRNA targeting the DNAJB1-PRKACA fusion junction in fibrolamellar hepatocellular carcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-conjugated siRNA targeting the DNAJB1-PRKACA fusion junction in fibrolamellar hepatocellular carcinoma.
185,403,37871778,10.1016/j.xphs.2023.10.026,chemistry,siRNA,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.
186,404,37871778,10.1016/j.xphs.2023.10.026,delivery,siRNA,PubMed abstract sentence 1,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.
187,405,37871778,10.1016/j.xphs.2023.10.026,assay,siRNA,PubMed abstract sentence 3,preclinical;model;experiment,"assay candidate; matched derived terms: preclinical, model, experiment; source title: Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.
189,407,37871778,10.1016/j.xphs.2023.10.026,benchmark,siRNA,PubMed abstract sentence 3,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mechanistic Pharmacokinetics and Pharmacodynamics of GalNAc-siRNA: Translational Model Involving Competitive Receptor-Mediated Disposition and RISC-Dependent Gene Silencing Applied to Givosiran.
190,410,42205867,10.2147/IJN.S596277,delivery,ASO/siRNA,PubMed abstract sentence 7,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: CA9-Targeted Liposomal Delivery of siETS1 Inhibits Clear Cell Renal Cell Carcinoma Progression by Disrupting the ETS1/MYC Regulatory Axis.",C,high_candidate,curator_rejected,reject,derived_annotations_only,CA9-Targeted Liposomal Delivery of siETS1 Inhibits Clear Cell Renal Cell Carcinoma Progression by Disrupting the ETS1/MYC Regulatory Axis.
192,414,40134366,10.1089/nat.2024.0047,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Hepatotoxicity Reduction Profiles of Antisense Oligonucleotides Containing Amido-Bridged Nucleic Acid and 2'-O,4'-C-Spirocyclopropylene Bridged Nucleic Acid.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Hepatotoxicity Reduction Profiles of Antisense Oligonucleotides Containing Amido-Bridged Nucleic Acid and 2'-O,4'-C-Spirocyclopropylene Bridged Nucleic Acid."
193,417,38648015,10.1089/nat.2023.0056,chemistry,ASO,PubMed abstract sentence 2,chemical;modification;phosphorothioate,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate; source title: Sequence- and Structure-Dependent Cytotoxicity of Phosphorothioate and 2'-O-Methyl Modified Single-Stranded Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Sequence- and Structure-Dependent Cytotoxicity of Phosphorothioate and 2'-O-Methyl Modified Single-Stranded Oligonucleotides.
194,418,38648015,10.1089/nat.2023.0056,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sequence- and Structure-Dependent Cytotoxicity of Phosphorothioate and 2'-O-Methyl Modified Single-Stranded Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sequence- and Structure-Dependent Cytotoxicity of Phosphorothioate and 2'-O-Methyl Modified Single-Stranded Oligonucleotides.
196,422,38978695,10.1016/j.omtn.2024.102161,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine."
198,426,39585752,10.1089/nat.2024.0057,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Combined Fertility and Developmental Toxicity Study with an Antisense Oligonucleotide Targeting Murine Apolipoprotein C-III mRNA in Mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Combined Fertility and Developmental Toxicity Study with an Antisense Oligonucleotide Targeting Murine Apolipoprotein C-III mRNA in Mice.
199,429,38227794,10.1089/nat.2023.0026,chemistry,ASO,PubMed abstract sentence 2,modified;galnac;lna;conjugate,"chemistry candidate; matched derived terms: modified, galnac, lna, conjugate; source title: Safety and Tolerability of GalNAc(3)-Conjugated Antisense Drugs Compared to the Same-Sequence 2'-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Safety and Tolerability of GalNAc(3)-Conjugated Antisense Drugs Compared to the Same-Sequence 2'-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data.
200,430,38227794,10.1089/nat.2023.0026,delivery,ASO,PubMed abstract sentence 1,galnac;conjugated;uptake,"delivery candidate; matched derived terms: galnac, conjugated, uptake; source title: Safety and Tolerability of GalNAc(3)-Conjugated Antisense Drugs Compared to the Same-Sequence 2'-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Safety and Tolerability of GalNAc(3)-Conjugated Antisense Drugs Compared to the Same-Sequence 2'-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data.
202,432,38227794,10.1089/nat.2023.0026,toxicity,ASO,PubMed abstract sentence 11,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Safety and Tolerability of GalNAc(3)-Conjugated Antisense Drugs Compared to the Same-Sequence 2'-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Safety and Tolerability of GalNAc(3)-Conjugated Antisense Drugs Compared to the Same-Sequence 2'-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data.
203,435,41820295,10.1177/21593337261429852,chemistry,ASO,PubMed abstract sentence 7,chemical;modification;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate, 2'-o; source title: Reduced Genotoxicity Testing Is Possible for Noncoding Oligonucleotide-Based Therapeutics Containing Well-Characterized Modifications: A European Regulatory Perspective.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Reduced Genotoxicity Testing Is Possible for Noncoding Oligonucleotide-Based Therapeutics Containing Well-Characterized Modifications: A European Regulatory Perspective.
204,436,41820295,10.1177/21593337261429852,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Reduced Genotoxicity Testing Is Possible for Noncoding Oligonucleotide-Based Therapeutics Containing Well-Characterized Modifications: A European Regulatory Perspective.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Reduced Genotoxicity Testing Is Possible for Noncoding Oligonucleotide-Based Therapeutics Containing Well-Characterized Modifications: A European Regulatory Perspective.
205,439,39846858,10.1089/nat.2024.0075,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Opportunities for More Tailored Approaches to Genotoxicity Testing and Carcinogenicity Strategy for Oligonucleotide Therapeutics: Outcome of an Industry Survey.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Opportunities for More Tailored Approaches to Genotoxicity Testing and Carcinogenicity Strategy for Oligonucleotide Therapeutics: Outcome of an Industry Survey.
207,443,39554992,10.1016/j.omtn.2024.102359,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca(2+) and Mg(2+) in the formulation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca(2+) and Mg(2+) in the formulation.
209,447,38895198,10.1101/2024.06.06.597639,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca(2+) and Mg(2+) in the formulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca(2+) and Mg(2+) in the formulation.
212,454,37567502,10.1016/j.addr.2023.115052,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics.
214,458,41950836,10.1016/j.jhazmat.2026.141957,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: Combined toxicity prediction of deoxynivalenol and fumonisin B(1) by physiologically based toxicokinetic modelling and in vitro toxicity mechanism study on astrocyte-like C6 cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Combined toxicity prediction of deoxynivalenol and fumonisin B(1) by physiologically based toxicokinetic modelling and in vitro toxicity mechanism study on astrocyte-like C6 cells.
216,462,42102394,10.1158/2767-9764.CRC-25-0511,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Novel Mechanism of and Therapeutic Approach for Anthracycline-Induced Cardiotoxicity (AIC).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Novel Mechanism of and Therapeutic Approach for Anthracycline-Induced Cardiotoxicity (AIC).
217,465,42067012,10.1016/j.cbi.2026.112104,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: GPD1-mediated neuronal lipotoxicity drives aconitine-induced mitochondrial collapse and lethality.",B,high_candidate,curator_rejected,reject,derived_annotations_only,GPD1-mediated neuronal lipotoxicity drives aconitine-induced mitochondrial collapse and lethality.
218,468,42049637,10.1177/15230864261443785,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Clotrimazole-Mediated Autophagy to Protect Against Cisplatin-Induced Ototoxicity via the AMPK/mTOR/TFEB Pathway in Mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Clotrimazole-Mediated Autophagy to Protect Against Cisplatin-Induced Ototoxicity via the AMPK/mTOR/TFEB Pathway in Mice.
220,472,42044856,10.1016/j.ibmb.2026.104562,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cold-induced Cpt1 repression uncouples lipid mobilization from oxidation and drives lipotoxicity during honeybee metamorphosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cold-induced Cpt1 repression uncouples lipid mobilization from oxidation and drives lipotoxicity during honeybee metamorphosis.
221,475,42031540,10.1002/tox.70108,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Prosopis africana Pod Methanolic Extract Attenuates Multi-Metal Oxidative Injury in Thyroid and Thymus: Evidence for Nrf2/NF-κB Modulation and Implications for Environmental Toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Prosopis africana Pod Methanolic Extract Attenuates Multi-Metal Oxidative Injury in Thyroid and Thymus: Evidence for Nrf2/NF-κB Modulation and Implications for Environmental Toxicity.
222,478,41979221,10.1080/17425247.2026.2659926,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology.
224,482,41948821,10.1161/CIRCRESAHA.125.327827,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: EV-Mediated Intracardiac Crosstalk Mitigates Doxorubicin-Induced Cardiotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,EV-Mediated Intracardiac Crosstalk Mitigates Doxorubicin-Induced Cardiotoxicity.
231,497,40119340,10.1186/s12944-024-02389-2,assay,ASO,PubMed abstract sentence 11,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Safety and efficacy of antisense oligonucleotides on triglyceride, apolipoprotein C-III, and other lipid parameters levels in hypertriglyceridemia; a network meta-analysis of randomized controlled trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Safety and efficacy of antisense oligonucleotides on triglyceride, apolipoprotein C-III, and other lipid parameters levels in hypertriglyceridemia; a network meta-analysis of randomized controlled trials."
236,506,39569667,10.1039/d4ob01350f,chemistry,ASO/siRNA,PubMed abstract sentence 2,modification;modified;lna,"chemistry candidate; matched derived terms: modification, modified, lna; source title: Synthesis of LNA gapmers that replace a phosphorothioate linkage with a sulfonamide in the gap region, and their ability to form duplexes with complementary RNA targets.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Synthesis of LNA gapmers that replace a phosphorothioate linkage with a sulfonamide in the gap region, and their ability to form duplexes with complementary RNA targets."
237,507,39569667,10.1039/d4ob01350f,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synthesis of LNA gapmers that replace a phosphorothioate linkage with a sulfonamide in the gap region, and their ability to form duplexes with complementary RNA targets.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Synthesis of LNA gapmers that replace a phosphorothioate linkage with a sulfonamide in the gap region, and their ability to form duplexes with complementary RNA targets."
239,511,39500647,10.1016/j.jcf.2024.10.004,toxicity,ASO,PubMed abstract sentence 7,safety;adverse;tolerability,"toxicity candidate; matched derived terms: safety, adverse, tolerability; source title: A phase I study assessing the safety and tolerability of SPL84, an inhaled antisense oligonucleotide for treatment of cystic fibrosis patients with the 3849 +10kb C->T.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"A phase I study assessing the safety and tolerability of SPL84, an inhaled antisense oligonucleotide for treatment of cystic fibrosis patients with the 3849 +10kb C->T."
240,514,39164364,10.1038/s41598-024-70294-w,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Molsidomine provides neuroprotection against vincristine-induced peripheral neurotoxicity through soluble guanylyl cyclase activation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Molsidomine provides neuroprotection against vincristine-induced peripheral neurotoxicity through soluble guanylyl cyclase activation.
241,517,39119918,10.1093/nar/gkae686,chemistry,ASO,PubMed abstract sentence 3,chemical;modification;phosphorothioate,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate; source title: Efficacy, biodistribution and safety comparison of chemically modified antisense oligonucleotides in the retina.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Efficacy, biodistribution and safety comparison of chemically modified antisense oligonucleotides in the retina."
242,518,39119918,10.1093/nar/gkae686,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Efficacy, biodistribution and safety comparison of chemically modified antisense oligonucleotides in the retina.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Efficacy, biodistribution and safety comparison of chemically modified antisense oligonucleotides in the retina."
244,522,38042877,10.1038/s41467-023-43714-0,offtarget,ASO,PubMed abstract sentence 4,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry.
245,525,37638886,10.1021/jacs.3c04744,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs."
249,531,37185731,10.3390/cimb45040207,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibitory Effect of Phosphorothioate Oligonucleotide Complementary to G6PD mRNA on Murine Melanoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Inhibitory Effect of Phosphorothioate Oligonucleotide Complementary to G6PD mRNA on Murine Melanoma.
250,534,37021418,10.2174/1570159X21666230404103914,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MiR-142-3p is a Critical Modulator of TNF-mediated Neuronal Toxicity in Multiple Sclerosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,MiR-142-3p is a Critical Modulator of TNF-mediated Neuronal Toxicity in Multiple Sclerosis.
251,537,36454263,10.1089/nat.2022.0044,chemistry,ASO,PubMed abstract sentence 3,modified;galnac;lna;conjugate,"chemistry candidate; matched derived terms: modified, galnac, lna, conjugate; source title: Integrated Assessment of Phase 2 Data on GalNAc(3)-Conjugated 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Integrated Assessment of Phase 2 Data on GalNAc(3)-Conjugated 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides.
252,538,36454263,10.1089/nat.2022.0044,delivery,ASO,PubMed abstract sentence 1,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Integrated Assessment of Phase 2 Data on GalNAc(3)-Conjugated 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Integrated Assessment of Phase 2 Data on GalNAc(3)-Conjugated 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides.
254,542,42042810,10.3390/vaccines14040334,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CTLA-4 Antisense Oligonucleotide Contributes to Enhanced Immunogenicity of an Adjuvanted Recombinant Sporothrix spp. Enolase Antigen.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CTLA-4 Antisense Oligonucleotide Contributes to Enhanced Immunogenicity of an Adjuvanted Recombinant Sporothrix spp. Enolase Antigen.
255,545,41551726,10.1093/narmme/ugag002,chemistry,ASO,PubMed abstract sentence 1,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: A therapeutic antisense oligonucleotide encompassing 2'-O-methoxyethyl modification triggers unique perturbation of the transcriptome.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A therapeutic antisense oligonucleotide encompassing 2'-O-methoxyethyl modification triggers unique perturbation of the transcriptome.
258,552,41204722,10.1177/21593337251387423,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Immunogenicity Risk Assessment for Nucleic Acid Therapeutics: A Comprehensive Evaluation for ASO, siRNA, and Nonvaccine mRNA/LNP Therapies by the IQ Consortium.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Immunogenicity Risk Assessment for Nucleic Acid Therapeutics: A Comprehensive Evaluation for ASO, siRNA, and Nonvaccine mRNA/LNP Therapies by the IQ Consortium."
259,553,41204722,10.1177/21593337251387423,toxicity,siRNA,PubMed abstract sentence 2,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Immunogenicity Risk Assessment for Nucleic Acid Therapeutics: A Comprehensive Evaluation for ASO, siRNA, and Nonvaccine mRNA/LNP Therapies by the IQ Consortium.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Immunogenicity Risk Assessment for Nucleic Acid Therapeutics: A Comprehensive Evaluation for ASO, siRNA, and Nonvaccine mRNA/LNP Therapies by the IQ Consortium."
261,559,40034209,10.1016/j.omtn.2025.102476,chemistry,ASO,PubMed abstract sentence 4,modified;2'-moe,"chemistry candidate; matched derived terms: modified, 2'-moe; source title: SNA-modified antisense oligonucleotides: A new pathway for renal targeting?",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,SNA-modified antisense oligonucleotides: A new pathway for renal targeting?
262,560,40034209,10.1016/j.omtn.2025.102476,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic;renal;tolerability,"toxicity candidate; matched derived terms: toxicity, toxic, renal, tolerability; source title: SNA-modified antisense oligonucleotides: A new pathway for renal targeting?",B,high_candidate,curator_rejected,reject,derived_annotations_only,SNA-modified antisense oligonucleotides: A new pathway for renal targeting?
263,563,39772540,10.1021/acs.jpcb.4c07517,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Influence of Length and Sequence of Complementary Oligonucleotides on the Spectral and Time-Resolved Fluorescence Properties of an H-Type Excitonic Dimer-Bearing Antisense Oligonucleotide.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Influence of Length and Sequence of Complementary Oligonucleotides on the Spectral and Time-Resolved Fluorescence Properties of an H-Type Excitonic Dimer-Bearing Antisense Oligonucleotide.
267,573,42030965,10.1016/S0140-6736(26)00690-2,assay,siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Efficacy and safety of cemdisiran siRNA in myasthenia gravis (NIMBLE): a double-blind, randomised, placebo-controlled, phase 3 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Efficacy and safety of cemdisiran siRNA in myasthenia gravis (NIMBLE): a double-blind, randomised, placebo-controlled, phase 3 trial."
268,574,42030965,10.1016/S0140-6736(26)00690-2,toxicity,siRNA,PubMed abstract sentence 9,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Efficacy and safety of cemdisiran siRNA in myasthenia gravis (NIMBLE): a double-blind, randomised, placebo-controlled, phase 3 trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Efficacy and safety of cemdisiran siRNA in myasthenia gravis (NIMBLE): a double-blind, randomised, placebo-controlled, phase 3 trial."
269,577,41984094,10.1007/s00204-026-04370-7,assay,siRNA,PubMed abstract sentence 3,model;phase,"assay candidate; matched derived terms: model, phase; source title: Imaging and safety profiling of inhaled siRNA RyR2 in human respiratory models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Imaging and safety profiling of inhaled siRNA RyR2 in human respiratory models.
270,578,41984094,10.1007/s00204-026-04370-7,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Imaging and safety profiling of inhaled siRNA RyR2 in human respiratory models.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Imaging and safety profiling of inhaled siRNA RyR2 in human respiratory models.
272,582,41970250,10.1016/j.mtbio.2026.103059,chemistry,ASO/siRNA,PubMed abstract sentence 6,modified;galnac;lna,"chemistry candidate; matched derived terms: modified, galnac, lna; source title: Dual targeted gene delivery strategy mediated by GalNAc-modified lipid nanoparticles enhances liver regeneration through specific knockdown of MKK4.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dual targeted gene delivery strategy mediated by GalNAc-modified lipid nanoparticles enhances liver regeneration through specific knockdown of MKK4.
273,583,41970250,10.1016/j.mtbio.2026.103059,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle;galnac;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, galnac, lnp; source title: Dual targeted gene delivery strategy mediated by GalNAc-modified lipid nanoparticles enhances liver regeneration through specific knockdown of MKK4.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dual targeted gene delivery strategy mediated by GalNAc-modified lipid nanoparticles enhances liver regeneration through specific knockdown of MKK4.
276,588,41669684,10.3389/fphar.2026.1736821,toxicity,siRNA,PubMed abstract sentence 12,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis.
277,591,41646886,10.1016/j.omtn.2026.102835,chemistry,ASO,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: 2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs.",B,high_candidate,curator_verified,accept,derived_annotations_only,2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs.
278,592,41646886,10.1016/j.omtn.2026.102835,offtarget,ASO,PubMed abstract sentence 4,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: 2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs.
279,595,41616799,10.1016/S2213-8587(25)00351-1,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial."
282,600,41565351,10.1177/10915818261417235,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: An Industry Perspective on Key Considerations for the ICH S13 Guidance: Nonclinical Safety Evaluations of Oligonucleotide-Based Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,An Industry Perspective on Key Considerations for the ICH S13 Guidance: Nonclinical Safety Evaluations of Oligonucleotide-Based Therapeutics.
283,603,41467115,10.1016/j.omtn.2025.102693,chemistry,siRNA,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA.",B,high_candidate,curator_verified,accept,derived_annotations_only,An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA.
284,604,41467115,10.1016/j.omtn.2025.102693,offtarget,siRNA,PubMed abstract sentence 3,off-target;unintended,"offtarget candidate; matched derived terms: off-target, unintended; source title: An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA.
285,609,41303530,10.3390/ijms262211047,chemistry,ASO,PubMed abstract sentence 7,modified;lna,"chemistry candidate; matched derived terms: modified, lna; source title: Structural Characterization of DDX23 5' UTR Regulatory Elements and Their Targeting by LNA-Modified Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structural Characterization of DDX23 5' UTR Regulatory Elements and Their Targeting by LNA-Modified Antisense Oligonucleotides.
286,612,40654713,10.1101/2025.05.01.651722,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Anti-Sense Oligonucleotide as a Therapeutic for Synucleinopathies: Pharmacokinetic, Safety and Efficacy Evaluation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Anti-Sense Oligonucleotide as a Therapeutic for Synucleinopathies: Pharmacokinetic, Safety and Efficacy Evaluation."
287,615,39580013,10.1016/j.yrtph.2024.105743,chemistry,ASO,PubMed abstract sentence 1,modified;2'-o;2'-moe,"chemistry candidate; matched derived terms: modified, 2'-o, 2'-moe; source title: Carcinogenicity assessment of inotersen in Tg.rasH2 mice and Sprague-Dawley rats: Implications for 2'-MOE antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Carcinogenicity assessment of inotersen in Tg.rasH2 mice and Sprague-Dawley rats: Implications for 2'-MOE antisense oligonucleotides.
290,622,38570436,10.1208/s12248-024-00914-w,chemistry,siRNA,PubMed abstract sentence 5,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Cross-Reactive Polyclonal Antibodies Raised Against GalNAc-Conjugated siRNA Recognize Mostly the GalNAc Moiety.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cross-Reactive Polyclonal Antibodies Raised Against GalNAc-Conjugated siRNA Recognize Mostly the GalNAc Moiety.
291,623,38570436,10.1208/s12248-024-00914-w,delivery,siRNA,PubMed abstract sentence 5,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Cross-Reactive Polyclonal Antibodies Raised Against GalNAc-Conjugated siRNA Recognize Mostly the GalNAc Moiety.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cross-Reactive Polyclonal Antibodies Raised Against GalNAc-Conjugated siRNA Recognize Mostly the GalNAc Moiety.
294,628,37920238,10.1016/j.omtm.2023.101122,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Awake intracerebroventricular delivery and safety assessment of oligonucleotides in a large animal model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Awake intracerebroventricular delivery and safety assessment of oligonucleotides in a large animal model.
296,632,37824025,10.1007/s40262-023-01314-7,chemistry,siRNA,PubMed abstract sentence 5,chemical;galnac;lna,"chemistry candidate; matched derived terms: chemical, galnac, lna; source title: Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs).
297,633,37824025,10.1007/s40262-023-01314-7,delivery,siRNA,PubMed abstract sentence 1,galnac;uptake,"delivery candidate; matched derived terms: galnac, uptake; source title: Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs).",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs).
300,640,37365583,10.1186/s13045-023-01468-8,chemistry,ASO/siRNA,PubMed abstract sentence 1,modified;phosphorothioate;lna,"chemistry candidate; matched derived terms: modified, phosphorothioate, lna; source title: Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study."
301,641,37365583,10.1186/s13045-023-01468-8,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study."
302,642,37365583,10.1186/s13045-023-01468-8,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study."
303,645,36725319,10.1261/rna.079526.122,chemistry,siRNA,PubMed abstract sentence 7,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency.
305,649,42156611,10.1208/s12248-026-01260-9,toxicity,siRNA,PubMed abstract sentence 9,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Immunogenicity Assessment for siRNA Therapeutics: A Risk-Based Proposal for Event-Driven Testing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Immunogenicity Assessment for siRNA Therapeutics: A Risk-Based Proposal for Event-Driven Testing.
309,659,42013287,10.1021/acs.jcim.5c02975,chemistry,siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Probing the hAGO2-siRNA Interactions: A Molecular Dynamics Study on the Impact of Chemical Modifications in the Seed Region.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Probing the hAGO2-siRNA Interactions: A Molecular Dynamics Study on the Impact of Chemical Modifications in the Seed Region.
311,661,42013287,10.1021/acs.jcim.5c02975,offtarget,siRNA,PubMed abstract sentence 1,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: Probing the hAGO2-siRNA Interactions: A Molecular Dynamics Study on the Impact of Chemical Modifications in the Seed Region.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Probing the hAGO2-siRNA Interactions: A Molecular Dynamics Study on the Impact of Chemical Modifications in the Seed Region.
312,664,41984862,10.1371/journal.pone.0347417,toxicity,ASO/siRNA,PubMed abstract sentence 7,safety;risk;adverse,"toxicity candidate; matched derived terms: safety, risk, adverse; source title: Assessing the real-world safety of vutrisiran for transthyretin-mediated amyloidosis with polyneuropathy: Based on WHO-VigiAccess and FAERS databases.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Assessing the real-world safety of vutrisiran for transthyretin-mediated amyloidosis with polyneuropathy: Based on WHO-VigiAccess and FAERS databases.
315,671,42211065,10.1016/j.mtbio.2026.103260,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: CXCR4 antagonistic lipid nanoparticles loading siRNA combat refractory AML through AML1-ETO depletion and homoharringtonine sensitization.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CXCR4 antagonistic lipid nanoparticles loading siRNA combat refractory AML through AML1-ETO depletion and homoharringtonine sensitization.
316,674,42198843,10.1016/j.ymthe.2026.05.010,delivery,ASO,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticle delivery of antisense gapmers attenuates pathology in a mouse model of facioscapulohumeral muscular dystrophy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle delivery of antisense gapmers attenuates pathology in a mouse model of facioscapulohumeral muscular dystrophy.
321,681,42152976,10.2147/IJN.S604443,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Prenatal Delivery of HIF-1α siRNA Using Transferrin-Modified Lipid Nanoparticles Alleviates Hypoxia-Induced Neurodevelopmental Abnormalities via PTEN/PI3K/AKT Signaling.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prenatal Delivery of HIF-1α siRNA Using Transferrin-Modified Lipid Nanoparticles Alleviates Hypoxia-Induced Neurodevelopmental Abnormalities via PTEN/PI3K/AKT Signaling.
330,702,42055150,10.1016/j.ijpharm.2026.126917,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Peptide modified lipid nanoparticles Co-Delivering IL-12 mRNA and PD-L1 siRNA for glioblastoma immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Peptide modified lipid nanoparticles Co-Delivering IL-12 mRNA and PD-L1 siRNA for glioblastoma immunotherapy.
332,706,42036929,10.1002/ps.70837,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chitosan-protected dsRNA increases efficacy against Helicoverpa armigera without compromising biosafety for pollinators.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Chitosan-protected dsRNA increases efficacy against Helicoverpa armigera without compromising biosafety for pollinators.
334,714,41977221,10.3390/ijms27073032,delivery,siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: siRNA Nanoparticle Delivery Strategies and Clinical Trial Advances in Tumor Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA Nanoparticle Delivery Strategies and Clinical Trial Advances in Tumor Therapy.
336,716,41977221,10.3390/ijms27073032,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: siRNA Nanoparticle Delivery Strategies and Clinical Trial Advances in Tumor Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA Nanoparticle Delivery Strategies and Clinical Trial Advances in Tumor Therapy.
340,726,41957800,10.1186/s12985-026-03155-9,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: An LNP antiviral siRNA drug cocktail delivered intranasally is effective against a range of respiratory viruses.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,An LNP antiviral siRNA drug cocktail delivered intranasally is effective against a range of respiratory viruses.
343,731,41938534,10.3389/fcell.2026.1788805,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Integrating multi-omics and network toxicology to identify FIS1 as a key target of environmental pollutants in male infertility.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Integrating multi-omics and network toxicology to identify FIS1 as a key target of environmental pollutants in male infertility.
344,734,41923247,10.1186/s12951-026-04312-6,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Dual-targeted lipid nanoparticles for TET3 siRNA delivery: nanobiotechnology strategy to remodel tumor immune microenvironment in hepatocellular carcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dual-targeted lipid nanoparticles for TET3 siRNA delivery: nanobiotechnology strategy to remodel tumor immune microenvironment in hepatocellular carcinoma.
348,740,41919978,10.1021/acsnano.5c21452,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles.
349,743,41917970,10.1186/s13045-026-01785-8,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: CXCR4-antagonistic peptide-decorated lipid nanoparticles for co- delivery of AML1-ETO siRNA to enhance chemotherapy in refractory AML.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CXCR4-antagonistic peptide-decorated lipid nanoparticles for co- delivery of AML1-ETO siRNA to enhance chemotherapy in refractory AML.
352,748,41917770,10.1111/dom.70717,toxicity,ASO/siRNA,PubMed abstract sentence 10,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Efficacy and Safety of Apolipoprotein C-III Inhibitors in Hypertriglyceridemia: A Network Meta-Analysis of Randomised Controlled Trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and Safety of Apolipoprotein C-III Inhibitors in Hypertriglyceridemia: A Network Meta-Analysis of Randomised Controlled Trials.
353,751,41907143,10.3389/fmolb.2026.1785592,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Efficiency and safety of five different agents for in vivo delivery of novel bioengineered RNAi molecules.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficiency and safety of five different agents for in vivo delivery of novel bioengineered RNAi molecules.
356,762,41869536,10.3389/fcvm.2026.1758366,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Efficacy and safety of lipoprotein(a)-targeted therapeutics: a systematic review and network meta-analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and safety of lipoprotein(a)-targeted therapeutics: a systematic review and network meta-analysis.
359,769,41847300,10.1016/j.bbrep.2026.102534,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Dual knockdown of Alox15 and TGF-β1 by lipid nanoparticle-delivered siRNA in bleomycin-induced pulmonary fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dual knockdown of Alox15 and TGF-β1 by lipid nanoparticle-delivered siRNA in bleomycin-induced pulmonary fibrosis.
361,775,41814159,10.1177/21593337251405312,chemistry,ASO,PubMed abstract sentence 2,phosphorothioate;conjugate,"chemistry candidate; matched derived terms: phosphorothioate, conjugate; source title: Conjugated Antisense Oligonucleotides for Skipping of Duchenne Muscular Dystrophy Exon 53: A Cautionary Study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Conjugated Antisense Oligonucleotides for Skipping of Duchenne Muscular Dystrophy Exon 53: A Cautionary Study.
364,780,41810141,10.1016/j.omtn.2026.102871,chemistry,ASO/siRNA,PubMed abstract sentence 7,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Enhanced liver-targeted delivery with ribofuranose-based GalNAc conjugates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced liver-targeted delivery with ribofuranose-based GalNAc conjugates.
365,781,41810141,10.1016/j.omtn.2026.102871,delivery,ASO/siRNA,PubMed abstract sentence 8,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: Enhanced liver-targeted delivery with ribofuranose-based GalNAc conjugates.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced liver-targeted delivery with ribofuranose-based GalNAc conjugates.
367,785,41802273,10.1080/15257770.2026.2640829,chemistry,siRNA,PubMed abstract sentence 4,chemical;modification;2'-o,"chemistry candidate; matched derived terms: chemical, modification, 2'-o; source title: Improve the efficiency of gene silencing through 2'-O-methyl modification of the bases in siRNA terminus.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Improve the efficiency of gene silencing through 2'-O-methyl modification of the bases in siRNA terminus.
373,797,41708903,10.1007/s13346-026-02076-y,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Comparative analysis of clinically approved lipid nanoparticles for intranasal siRNA delivery against SARS-CoV-2.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comparative analysis of clinically approved lipid nanoparticles for intranasal siRNA delivery against SARS-CoV-2.
376,802,41704705,10.3389/fmed.2026.1719202,chemistry,ASO,PubMed abstract sentence 10,modification;modified;lna,"chemistry candidate; matched derived terms: modification, modified, lna; source title: Investigation of the activity of phosphothioate and phosphothioate-LNA-modified oligonucleotides against HIV-1.",B,high_candidate,curator_verified,accept,derived_annotations_only,Investigation of the activity of phosphothioate and phosphothioate-LNA-modified oligonucleotides against HIV-1.
382,818,41399312,10.1002/smll.202509094,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery of Antisense Oligonucleotides Using the Nano-Cell Vesicle Technology System (nCVTs) for Targeted Cancer Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Delivery of Antisense Oligonucleotides Using the Nano-Cell Vesicle Technology System (nCVTs) for Targeted Cancer Therapy.
383,821,41365067,10.1016/j.bioorg.2025.109342,chemistry,ASO,PubMed abstract sentence 3,modification;2'-o;lna,"chemistry candidate; matched derived terms: modification, 2'-o, lna; source title: Structural and functional characterization of chemically modified antisense oligonucleotides targeting miR-214-3p in endothelial cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structural and functional characterization of chemically modified antisense oligonucleotides targeting miR-214-3p in endothelial cells.
384,824,41289434,10.1097/FJC.0000000000001778,toxicity,ASO/siRNA,PubMed abstract sentence 1,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Muscle Adverse Events Associated With Inclisiran: Data Mining of FAERS Database and Mendelian Randomization Analysis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Muscle Adverse Events Associated With Inclisiran: Data Mining of FAERS Database and Mendelian Randomization Analysis.
387,829,41274662,10.1177/21593337251391029,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Class-Specific Adverse Events of Patients Treated with Small Interfering RNA Therapeutics: A Disproportionality Analysis of the United States Food and Drug Administration Adverse Event Reporting System Database Based on the MY FAERS Platform.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Class-Specific Adverse Events of Patients Treated with Small Interfering RNA Therapeutics: A Disproportionality Analysis of the United States Food and Drug Administration Adverse Event Reporting System Database Based on the MY FAERS Platform.
390,836,40169808,10.1038/s41434-025-00529-6,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Early life safety profiling of gene therapy for spinal muscular atrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Early life safety profiling of gene therapy for spinal muscular atrophy.
397,855,41222242,10.1177/17539447251390782,toxicity,ASO/siRNA,PubMed abstract sentence 9,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Neurological efficacy and safety of RNA therapeutics in hereditary transthyretin amyloidosis: a systematic review and meta-analysis of randomized controlled trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Neurological efficacy and safety of RNA therapeutics in hereditary transthyretin amyloidosis: a systematic review and meta-analysis of randomized controlled trials.
404,884,40849139,10.1016/S0140-6736(25)00979-1,assay,ASO,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Antisense oligonucleotide DGAT-2 inhibitor, ION224, for metabolic dysfunction-associated steatohepatitis (ION224-CS2): results of a 51-week, multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Antisense oligonucleotide DGAT-2 inhibitor, ION224, for metabolic dysfunction-associated steatohepatitis (ION224-CS2): results of a 51-week, multicentre, randomised, double-blind, placebo-controlled, phase 2 trial."
405,887,40763041,10.1002/psp4.70076,assay,ASO,PubMed abstract sentence 1,model;phase,"assay candidate; matched derived terms: model, phase; source title: A Case Study of Model-Informed Drug Development of a Novel PCSK9 Antisense Oligonucleotide. Part 2: Phase 2 to Phase 3.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Case Study of Model-Informed Drug Development of a Novel PCSK9 Antisense Oligonucleotide. Part 2: Phase 2 to Phase 3.
408,898,40692538,10.2147/IJN.S510937,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;galnac;lna,"chemistry candidate; matched derived terms: modified, galnac, lna; source title: Protective Effects of GalNac-Modified Red Blood Cell-Derived Extracellular Vesicles Against Liver Diseases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Protective Effects of GalNac-Modified Red Blood Cell-Derived Extracellular Vesicles Against Liver Diseases.
409,899,40692538,10.2147/IJN.S510937,delivery,ASO/siRNA,PubMed abstract sentence 5,galnac;uptake,"delivery candidate; matched derived terms: galnac, uptake; source title: Protective Effects of GalNac-Modified Red Blood Cell-Derived Extracellular Vesicles Against Liver Diseases.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Protective Effects of GalNac-Modified Red Blood Cell-Derived Extracellular Vesicles Against Liver Diseases.
410,900,40692538,10.2147/IJN.S510937,toxicity,ASO/siRNA,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Protective Effects of GalNac-Modified Red Blood Cell-Derived Extracellular Vesicles Against Liver Diseases.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Protective Effects of GalNac-Modified Red Blood Cell-Derived Extracellular Vesicles Against Liver Diseases.
414,916,40496001,10.1016/j.omtm.2025.101489,delivery,ASO,PubMed abstract sentence 4,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Anti-TNF-α antisense-oligonucleotide-conjugated PLG nanoparticles protect transplanted islets.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Anti-TNF-α antisense-oligonucleotide-conjugated PLG nanoparticles protect transplanted islets.
419,935,40412657,10.1016/j.jconrel.2025.113865,delivery,ASO,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: VPS9D1-AS1 antisense therapy via lipid nanoparticles reprograms cold tumors and enhances immunotherapy in colorectal cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,VPS9D1-AS1 antisense therapy via lipid nanoparticles reprograms cold tumors and enhances immunotherapy in colorectal cancer.
424,946,40324532,10.1016/j.jconrel.2025.113811,chemistry,siRNA,PubMed abstract sentence 9,modified;conjugate,"chemistry candidate; matched derived terms: modified, conjugate; source title: Delivery of Itgb1-siRNA by triptolide-modified and anti-Flt1 peptide-guided ionizable cationic LNPs for targeted therapy of corneal neovascularization.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of Itgb1-siRNA by triptolide-modified and anti-Flt1 peptide-guided ionizable cationic LNPs for targeted therapy of corneal neovascularization.
425,947,40324532,10.1016/j.jconrel.2025.113811,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Delivery of Itgb1-siRNA by triptolide-modified and anti-Flt1 peptide-guided ionizable cationic LNPs for targeted therapy of corneal neovascularization.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of Itgb1-siRNA by triptolide-modified and anti-Flt1 peptide-guided ionizable cationic LNPs for targeted therapy of corneal neovascularization.
426,948,40324532,10.1016/j.jconrel.2025.113811,toxicity,siRNA,PubMed abstract sentence 11,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Delivery of Itgb1-siRNA by triptolide-modified and anti-Flt1 peptide-guided ionizable cationic LNPs for targeted therapy of corneal neovascularization.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery of Itgb1-siRNA by triptolide-modified and anti-Flt1 peptide-guided ionizable cationic LNPs for targeted therapy of corneal neovascularization.
437,987,39793573,10.1016/j.xcrm.2024.101901,assay,ASO,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Phase 1/2 trial of brogidirsen: Dual-targeting antisense oligonucleotides for exon 44 skipping in Duchenne muscular dystrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phase 1/2 trial of brogidirsen: Dual-targeting antisense oligonucleotides for exon 44 skipping in Duchenne muscular dystrophy.
438,990,39653607,10.1080/17460441.2024.2440095,chemistry,ASO,PubMed abstract sentence 5,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Evolution of antisense oligonucleotides: navigating nucleic acid chemistry and delivery challenges.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evolution of antisense oligonucleotides: navigating nucleic acid chemistry and delivery challenges.
443,1001,39886125,10.1136/bmjonc-2023-000133,assay,ASO,PubMed abstract sentence 1,preclinical;experiment;trial,"assay candidate; matched derived terms: preclinical, experiment, trial; source title: Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch repair-deficient colorectal cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch repair-deficient colorectal cancer."
448,1026,39363329,10.1186/s12944-024-02297-5,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Efficacy and safety of olezarsen in lowering apolipoprotein C-III and triglycerides in healthy Japanese Americans.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficacy and safety of olezarsen in lowering apolipoprotein C-III and triglycerides in healthy Japanese Americans.
449,1029,39335447,10.3390/biomedicines12091933,delivery,ASO,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Calcium-Enhanced Medium-Based Delivery of Splice Modulating Antisense Oligonucleotides in 2D and 3D hiPSC-Derived Neuronal Models.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Calcium-Enhanced Medium-Based Delivery of Splice Modulating Antisense Oligonucleotides in 2D and 3D hiPSC-Derived Neuronal Models.
451,1031,39335447,10.3390/biomedicines12091933,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Calcium-Enhanced Medium-Based Delivery of Splice Modulating Antisense Oligonucleotides in 2D and 3D hiPSC-Derived Neuronal Models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Calcium-Enhanced Medium-Based Delivery of Splice Modulating Antisense Oligonucleotides in 2D and 3D hiPSC-Derived Neuronal Models.
452,1032,39335447,10.3390/biomedicines12091933,benchmark,ASO,PubMed abstract sentence 3,model;challenge,"benchmark candidate; matched derived terms: model, challenge; source title: Calcium-Enhanced Medium-Based Delivery of Splice Modulating Antisense Oligonucleotides in 2D and 3D hiPSC-Derived Neuronal Models.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Calcium-Enhanced Medium-Based Delivery of Splice Modulating Antisense Oligonucleotides in 2D and 3D hiPSC-Derived Neuronal Models.
453,1035,39126066,10.3390/ijms25158495,chemistry,ASO,PubMed abstract sentence 9,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Allele-Selective Thiomorpholino Antisense Oligonucleotides as a Therapeutic Approach for Fused-in-Sarcoma Amyotrophic Lateral Sclerosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Allele-Selective Thiomorpholino Antisense Oligonucleotides as a Therapeutic Approach for Fused-in-Sarcoma Amyotrophic Lateral Sclerosis.
456,1042,38271438,10.1371/journal.pone.0294847,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: A phase 2 open-label study of the safety and efficacy of weekly dosing of ATL1102 in patients with non-ambulatory Duchenne muscular dystrophy and pharmacology in mdx mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A phase 2 open-label study of the safety and efficacy of weekly dosing of ATL1102 in patients with non-ambulatory Duchenne muscular dystrophy and pharmacology in mdx mice.
457,1053,42166976,10.1016/j.phymed.2026.158282,toxicity,ASO/siRNA,PubMed abstract sentence 16,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: 5-O-Methylembelin disrupts the ACO1-TPI1 interaction to promote ferroptosis in clear cell renal cell carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,5-O-Methylembelin disrupts the ACO1-TPI1 interaction to promote ferroptosis in clear cell renal cell carcinoma.
458,1056,42142608,10.1016/j.cbi.2026.112146,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxic;renal,"toxicity candidate; matched derived terms: toxic, renal; source title: Forest-cultivated Epimedium koreanum Nakai mitigates organotin-induced renal injury and the exacerbation of diabetic nephropathy via the SIRT1/NRF2/PPARγ signaling pathways.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Forest-cultivated Epimedium koreanum Nakai mitigates organotin-induced renal injury and the exacerbation of diabetic nephropathy via the SIRT1/NRF2/PPARγ signaling pathways.
459,1059,42128249,10.1111/tpj.70924,offtarget,ASO/siRNA,PubMed abstract sentence 7,seed;transcriptome,"offtarget candidate; matched derived terms: seed, transcriptome; source title: The nucleotidyl transferase URT1-directed mRNA surveillance is critical for embryo and seedling development in Arabidopsis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The nucleotidyl transferase URT1-directed mRNA surveillance is critical for embryo and seedling development in Arabidopsis.
473,1093,41474128,10.1021/acsnano.5c17740,chemistry,ASO/siRNA,PubMed abstract sentence 10,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Phosphorothioate and 2'-Fluoro Ribose Substitution-Mediated Hydrophobic Effect Empowers RNA Probes for Highly Sensitive and Subtype-Selective miRNA Imaging.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phosphorothioate and 2'-Fluoro Ribose Substitution-Mediated Hydrophobic Effect Empowers RNA Probes for Highly Sensitive and Subtype-Selective miRNA Imaging.
474,1096,41443406,10.1016/j.kint.2025.11.017,assay,ASO/siRNA,PubMed abstract sentence 14,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: A single-arm phase 2 trial of an investigational RNA therapeutic to complement factor B sefaxersen for treatment of IgA nephropathy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A single-arm phase 2 trial of an investigational RNA therapeutic to complement factor B sefaxersen for treatment of IgA nephropathy.
479,1105,40848498,10.1016/j.saa.2025.126840,chemistry,ASO/siRNA,PubMed abstract sentence 2,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: A fluorescent aptasensor for accurate and sensitive detection of glyphosate based on asymmetrically competitive CRISPR/Cas12a with phosphorothioate-modified G-quadruplex.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A fluorescent aptasensor for accurate and sensitive detection of glyphosate based on asymmetrically competitive CRISPR/Cas12a with phosphorothioate-modified G-quadruplex.
481,1111,41399434,10.1016/j.omtm.2025.101632,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Leveraging the active conformation of LFA-1 as a potential target for hematological malignancies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Leveraging the active conformation of LFA-1 as a potential target for hematological malignancies.
488,1130,38800826,10.1093/nargab/lqae058,chemistry,ASO/siRNA,PubMed abstract sentence 5,modification;modified;phosphorothioate,"chemistry candidate; matched derived terms: modification, modified, phosphorothioate; source title: Structural dynamics of therapeutic nucleic acids with phosphorothioate backbone modifications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structural dynamics of therapeutic nucleic acids with phosphorothioate backbone modifications.
489,1133,36694259,10.1186/s12951-022-01764-4,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;phosphorothioate;conjugate,"chemistry candidate; matched derived terms: modified, phosphorothioate, conjugate; source title: Phosphorothioated amino-AS1411 aptamer functionalized stealth nanoliposome accelerates bio-therapeutic threshold of apigenin in neoplastic rat liver: a mechanistic approach.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phosphorothioated amino-AS1411 aptamer functionalized stealth nanoliposome accelerates bio-therapeutic threshold of apigenin in neoplastic rat liver: a mechanistic approach.
492,1140,42218144,10.1038/s41420-026-03119-6,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Targeted silencing of CLYBL with platelet-mimetic siRNA nanoparticles drives itaconate-mediated macrophage reprogramming and protects against sepsis-triggered lung cell death.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted silencing of CLYBL with platelet-mimetic siRNA nanoparticles drives itaconate-mediated macrophage reprogramming and protects against sepsis-triggered lung cell death.
495,1145,42216305,10.1002/psc.70105,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Structure-Guided Engineering of Histidine-Rich pH-Switchable Endosomolytic Peptides for Spleen-Selective siRNA Delivery to Inflammatory Macrophages.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Structure-Guided Engineering of Histidine-Rich pH-Switchable Endosomolytic Peptides for Spleen-Selective siRNA Delivery to Inflammatory Macrophages.
496,1148,42216038,10.1186/s13036-026-00701-5,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Tunable PEGylation platform for efficient siRNA delivery using mesoporous silica nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tunable PEGylation platform for efficient siRNA delivery using mesoporous silica nanoparticles.
498,1154,42208109,10.1016/j.phymed.2026.158327,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Ginseng-derived cholesterol analogues enhance pulmonary siRNA delivery and alleviate allergic asthma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ginseng-derived cholesterol analogues enhance pulmonary siRNA delivery and alleviate allergic asthma.
501,1161,42198221,10.3390/pharmaceutics18050527,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Emerging Non-Conventional Approaches in mRNA-LNP Formulation for Therapeutic Applications.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Emerging Non-Conventional Approaches in mRNA-LNP Formulation for Therapeutic Applications.
502,1164,42193329,10.3390/biomedicines14051002,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Effect of Short-Anchored PEGylated Lipids on Lipid Nanoparticle Characterization Profiles, Stability, and Efficacy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Effect of Short-Anchored PEGylated Lipids on Lipid Nanoparticle Characterization Profiles, Stability, and Efficacy."
503,1167,42193283,10.3390/biomedicines14050957,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Functionalized Lipid Nanoparticles for Targeted RNA Delivery in Immune and Inflammatory Diseases.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Functionalized Lipid Nanoparticles for Targeted RNA Delivery in Immune and Inflammatory Diseases.
507,1175,42184701,10.1016/j.dmd.2026.100305,chemistry,ASO,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Rapid assessment of metabolism and disposition of conjugated oligonucleotide vutrisiran in rats using a sensitive LC-HRMS platform.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rapid assessment of metabolism and disposition of conjugated oligonucleotide vutrisiran in rats using a sensitive LC-HRMS platform.
508,1176,42184701,10.1016/j.dmd.2026.100305,delivery,ASO,PubMed abstract sentence 1,delivery;galnac;conjugated,"delivery candidate; matched derived terms: delivery, galnac, conjugated; source title: Rapid assessment of metabolism and disposition of conjugated oligonucleotide vutrisiran in rats using a sensitive LC-HRMS platform.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rapid assessment of metabolism and disposition of conjugated oligonucleotide vutrisiran in rats using a sensitive LC-HRMS platform.
511,1183,42181752,10.1016/j.bonr.2026.101921,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticles for nucleic acid delivery to osteoblasts and osteoblast-lineage cells: A systematic review.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles for nucleic acid delivery to osteoblasts and osteoblast-lineage cells: A systematic review.
512,1184,42181752,10.1016/j.bonr.2026.101921,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Lipid nanoparticles for nucleic acid delivery to osteoblasts and osteoblast-lineage cells: A systematic review.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid nanoparticles for nucleic acid delivery to osteoblasts and osteoblast-lineage cells: A systematic review.
513,1187,42180053,10.3389/fonc.2026.1779803,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: A novel auto-fluorescent porphyrin-lipid nanoparticle strategy for CTNNB1 gene silencing in hepatocellular carcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A novel auto-fluorescent porphyrin-lipid nanoparticle strategy for CTNNB1 gene silencing in hepatocellular carcinoma.
515,1193,42177899,10.1016/j.colsurfb.2026.115816,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Multifunctional hybrid lipid-polymeric nanoparticle enabling resveratrol and siRNA co-delivery for enhanced cutaneous wound repair.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multifunctional hybrid lipid-polymeric nanoparticle enabling resveratrol and siRNA co-delivery for enhanced cutaneous wound repair.
517,1197,42173448,10.1016/j.jconrel.2026.115039,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Biomimetic lipid nanoparticles for macrophage reprogramming in cancer immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Biomimetic lipid nanoparticles for macrophage reprogramming in cancer immunotherapy.
518,1200,42167744,10.1021/acs.nanolett.6c00782,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Meta-Learning as a Promising Strategy for Lipid Nanoparticle Optimization and Ionizable Lipid Discovery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Meta-Learning as a Promising Strategy for Lipid Nanoparticle Optimization and Ionizable Lipid Discovery.
519,1203,42162746,10.1016/j.jbiotec.2026.05.009,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Dual-functional chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted Bcl-2 siRNA delivery and photothermal therapy in bladder cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dual-functional chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted Bcl-2 siRNA delivery and photothermal therapy in bladder cancer.
521,1207,42155236,10.1016/j.jcis.2026.140735,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: PEG-lipid structure controls in vitro PEG shedding, surface remodeling, and timing of lipid nanoparticle-mediated silencing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"PEG-lipid structure controls in vitro PEG shedding, surface remodeling, and timing of lipid nanoparticle-mediated silencing."
522,1208,42155236,10.1016/j.jcis.2026.140735,assay,ASO/siRNA,PubMed abstract sentence 10,screen;model,"assay candidate; matched derived terms: screen, model; source title: PEG-lipid structure controls in vitro PEG shedding, surface remodeling, and timing of lipid nanoparticle-mediated silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"PEG-lipid structure controls in vitro PEG shedding, surface remodeling, and timing of lipid nanoparticle-mediated silencing."
527,1217,42150356,10.1016/j.jcis.2026.140683,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipid@polymer hybrid nanoparticles for efficient siRNA transport across the lung barriers: Mechanistic insights into the role of Ionizable lipids.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid@polymer hybrid nanoparticles for efficient siRNA transport across the lung barriers: Mechanistic insights into the role of Ionizable lipids.
530,1226,42142676,10.1016/j.ijpharm.2026.126988,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Effect of vascular disrupting therapy by lipid nanoparticles on the tumor microenvironment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of vascular disrupting therapy by lipid nanoparticles on the tumor microenvironment.
531,1229,42138142,10.1021/acsnano.6c03013,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Optimization of Lipid Nanoparticles for Safe and Versatile Lung-Targeted RNA Delivery and Disease Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimization of Lipid Nanoparticles for Safe and Versatile Lung-Targeted RNA Delivery and Disease Therapy.
533,1233,42135712,10.1186/s12951-026-04511-1,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Galactosylated LNP-mediated hepatic Sam68 silencing improves glucose homeostasis in diabetes by suppressing gluconeogenesis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Galactosylated LNP-mediated hepatic Sam68 silencing improves glucose homeostasis in diabetes by suppressing gluconeogenesis.
537,1247,42117503,10.1021/acsami.6c04961,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Aptamer-Loaded Cubosome Lipid Nanoparticles for the Treatment of Tuberculosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-Loaded Cubosome Lipid Nanoparticles for the Treatment of Tuberculosis.
538,1250,42112626,10.1080/17435889.2026.2671280,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Pulmonary delivery of gene-loaded lipid nanoparticles for targeting TGF-β signaling in idiopathic pulmonary fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pulmonary delivery of gene-loaded lipid nanoparticles for targeting TGF-β signaling in idiopathic pulmonary fibrosis.
539,1251,42112626,10.1080/17435889.2026.2671280,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pulmonary delivery of gene-loaded lipid nanoparticles for targeting TGF-β signaling in idiopathic pulmonary fibrosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pulmonary delivery of gene-loaded lipid nanoparticles for targeting TGF-β signaling in idiopathic pulmonary fibrosis.
540,1254,42111825,10.7717/peerj.21147,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A biomimetic membrane platform for predictive screening and rational engineering of endosomally escaped lipid nanoparticle-CpG oligodeoxynucleotides delivery systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A biomimetic membrane platform for predictive screening and rational engineering of endosomally escaped lipid nanoparticle-CpG oligodeoxynucleotides delivery systems.
544,1262,42104082,10.1007/s13346-026-02115-8,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Double-coated PLGA nanoparticles with hierarchical surface architecture for CD44-targeted siRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Double-coated PLGA nanoparticles with hierarchical surface architecture for CD44-targeted siRNA delivery.
547,1269,42083118,10.1111/cts.70570,benchmark,ASO,PubMed abstract sentence 4,model;challenge,"benchmark candidate; matched derived terms: model, challenge; source title: Optimizing Oligonucleotide Therapeutics: A Model-Informed Drug Development Perspective.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimizing Oligonucleotide Therapeutics: A Model-Informed Drug Development Perspective.
549,1279,42060243,10.1007/s40259-026-00782-0,delivery,ASO/siRNA,PubMed abstract sentence 6,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Recent Developments in Lipid Nanoparticle-Mediated Delivery of Biotherapeutics and Gene Therapy Across the Blood-Brain Barrier.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent Developments in Lipid Nanoparticle-Mediated Delivery of Biotherapeutics and Gene Therapy Across the Blood-Brain Barrier.
556,1298,42005705,10.2147/IJN.S588018,delivery,siRNA,PubMed abstract sentence 5,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Preparation and Antitumor Activity of METTL3 SiRNA Nanoparticles Carried by Hypoxia Sensitive Polymer (mPEG-Azo-PEI).",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preparation and Antitumor Activity of METTL3 SiRNA Nanoparticles Carried by Hypoxia Sensitive Polymer (mPEG-Azo-PEI).
557,1301,42003109,10.1021/acsami.5c26100,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy.
559,1305,42001054,10.1186/s12951-026-04430-1,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Turmeric-derived exosome-coated ZIF-8 nanoplatform for targeted delivery of TGF-β1 siRNA in the treatment of liver fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Turmeric-derived exosome-coated ZIF-8 nanoplatform for targeted delivery of TGF-β1 siRNA in the treatment of liver fibrosis.
561,1309,42000178,10.1016/j.cis.2026.103897,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Advances in lipids design for LNP-mediated DNA and RNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in lipids design for LNP-mediated DNA and RNA delivery.
562,1310,42000178,10.1016/j.cis.2026.103897,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Advances in lipids design for LNP-mediated DNA and RNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in lipids design for LNP-mediated DNA and RNA delivery.
566,1320,41994867,10.1093/nar/gkag301,delivery,ASO,PubMed abstract sentence 4,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Development of a DUX4-targeting antibody oligonucleotide conjugate as a therapy for FSHD.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of a DUX4-targeting antibody oligonucleotide conjugate as a therapy for FSHD.
567,1323,41985596,10.1016/j.ijpharm.2026.126878,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Mucus-penetrating lipid nanoparticles overcome lung barriers for pulmonary co-delivery of siGSDMD and pDNA-SAP in idiopathic pulmonary fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mucus-penetrating lipid nanoparticles overcome lung barriers for pulmonary co-delivery of siGSDMD and pDNA-SAP in idiopathic pulmonary fibrosis.
569,1327,41970227,10.3389/finsc.2026.1770055,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Enhancing the delivery and stability of lipid nanoparticle-dsRNA formulations in the RNAi-recalcitrant fall armyworm (Spodoptera frugiperda).",C,high_candidate,curator_rejected,reject,derived_annotations_only,Enhancing the delivery and stability of lipid nanoparticle-dsRNA formulations in the RNAi-recalcitrant fall armyworm (Spodoptera frugiperda).
571,1333,41958534,10.1002/adfm.202526278,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Controlling Payload Heterogeneity in Lipid Nanoparticles for RNA-Based Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Controlling Payload Heterogeneity in Lipid Nanoparticles for RNA-Based Therapeutics.
572,1338,41950645,10.1016/j.biomaterials.2026.124202,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms.
573,1339,41950645,10.1016/j.biomaterials.2026.124202,assay,ASO/siRNA,PubMed abstract sentence 7,screen;model,"assay candidate; matched derived terms: screen, model; source title: Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms.
574,1340,41950645,10.1016/j.biomaterials.2026.124202,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms.
575,1341,41950645,10.1016/j.biomaterials.2026.124202,benchmark,ASO/siRNA,PubMed abstract sentence 7,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Human blood-brain barrier tissue model to characterize lipid nanoparticle delivery and transport mechanisms.
579,1357,41922680,10.1038/s41598-026-46162-0,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Co-delivery of cisplatin and Bmi1 siRNA via nanocapsules overcomes chemoresistance in ovarian cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Co-delivery of cisplatin and Bmi1 siRNA via nanocapsules overcomes chemoresistance in ovarian cancer.
581,1361,41911333,10.1002/advs.202515482,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: β-Triketone-Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,β-Triketone-Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery.
583,1365,41905408,10.1016/j.jconrel.2026.114874,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Baiting-enhanced extravasation of lipid nanoparticles for targeted co-delivery of decitabine and siTNF-α to the bone marrow niche in leukemia therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Baiting-enhanced extravasation of lipid nanoparticles for targeted co-delivery of decitabine and siTNF-α to the bone marrow niche in leukemia therapy.
584,1366,41905408,10.1016/j.jconrel.2026.114874,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Baiting-enhanced extravasation of lipid nanoparticles for targeted co-delivery of decitabine and siTNF-α to the bone marrow niche in leukemia therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Baiting-enhanced extravasation of lipid nanoparticles for targeted co-delivery of decitabine and siTNF-α to the bone marrow niche in leukemia therapy.
587,1373,41896658,10.1038/s41417-026-01020-z,delivery,siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: The application of nanoparticle-mediated siRNA delivery systems in ovarian cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The application of nanoparticle-mediated siRNA delivery systems in ovarian cancer.
588,1374,41896658,10.1038/s41417-026-01020-z,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The application of nanoparticle-mediated siRNA delivery systems in ovarian cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The application of nanoparticle-mediated siRNA delivery systems in ovarian cancer.
594,1386,41865046,10.1038/s41598-026-44095-2,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Microfluidic process-property correlations of dsRNA lipid nanoparticle formulations.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Microfluidic process-property correlations of dsRNA lipid nanoparticle formulations.
595,1389,41864150,10.1016/j.biomaterials.2026.124145,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A Calixsalan-based ionizable lipid for macrophage-targeted Trem2 siRNA delivery attenuates atherosclerosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Calixsalan-based ionizable lipid for macrophage-targeted Trem2 siRNA delivery attenuates atherosclerosis.
598,1396,41841193,10.1021/acs.molpharmaceut.5c01718,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Cytidinyl/Cationic Lipids-siRNA Delivery Silences MYC to Reprogram Macrophages and Circadian Rhythm for Cancer Treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cytidinyl/Cationic Lipids-siRNA Delivery Silences MYC to Reprogram Macrophages and Circadian Rhythm for Cancer Treatment.
605,1417,41625776,10.1016/j.ijpx.2026.100484,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;lnp;uptake,"delivery candidate; matched derived terms: delivery, lnp, uptake; source title: Recent advances in lipid nanoparticles for cancer vaccine delivery: Challenges and future perspectives.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent advances in lipid nanoparticles for cancer vaccine delivery: Challenges and future perspectives.
607,1421,41624517,10.1016/j.mtbio.2026.102774,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Programmable lipid nanoparticles for RNA therapeutics: Design principles and clinical translation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Programmable lipid nanoparticles for RNA therapeutics: Design principles and clinical translation.
610,1430,41611213,10.1021/acs.biomac.5c02041,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bifunctional Silk Nanospheres for Targeted Delivery of Oligonucleotide Therapeutics to VEGFR-Positive Cells in the Tumor Microenvironment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bifunctional Silk Nanospheres for Targeted Delivery of Oligonucleotide Therapeutics to VEGFR-Positive Cells in the Tumor Microenvironment.
611,1433,41169576,10.1021/jacsau.5c01005,chemistry,ASO,PubMed abstract sentence 2,modification;phosphorothioate;lna,"chemistry candidate; matched derived terms: modification, phosphorothioate, lna; source title: Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides.",B,high_candidate,curator_verified,accept,derived_annotations_only,"Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides."
612,1434,41169576,10.1021/jacsau.5c01005,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides."
613,1437,35801870,10.1093/nar/gkac562,chemistry,ASO,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides.",B,high_candidate,curator_verified,accept,derived_annotations_only,Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides.
614,1438,35801870,10.1093/nar/gkac562,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides.
615,1441,41315228,10.1038/s41467-025-65799-5,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity.
616,1442,41315228,10.1038/s41467-025-65799-5,offtarget,ASO,PubMed abstract sentence 1,off-target;unintended,"offtarget candidate; matched derived terms: off-target, unintended; source title: The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity.
617,1445,35736224,10.1093/nar/gkac539,chemistry,siRNA,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.
620,1448,35736224,10.1093/nar/gkac539,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.
621,1449,35736224,10.1093/nar/gkac539,offtarget,siRNA,PubMed abstract sentence 2,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.
622,1452,35213032,10.1007/978-1-0716-2010-6_26,assay,ASO,PubMed abstract sentence 4,screen;preclinical;phase,"assay candidate; matched derived terms: screen, preclinical, phase; source title: Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice.
623,1453,35213032,10.1007/978-1-0716-2010-6_26,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice.
624,1456,41928909,10.1039/d5cb00316d,chemistry,ASO,PubMed abstract sentence 3,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity.
625,1457,41928909,10.1039/d5cb00316d,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity.
626,1460,41916443,10.1016/j.cbi.2026.112058,toxicity,ASO/siRNA,PubMed abstract sentence 15,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: GSTA1 depletes glutathione and exacerbates oxidative stress in α-Amanitin-induced hepatotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,GSTA1 depletes glutathione and exacerbates oxidative stress in α-Amanitin-induced hepatotoxicity.
629,1469,38391508,10.3390/antibiotics13020122,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: General and Specific Cytotoxicity of Chimeric Antisense Oligonucleotides in Bacterial Cells and Human Cell Lines.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,General and Specific Cytotoxicity of Chimeric Antisense Oligonucleotides in Bacterial Cells and Human Cell Lines.
632,1474,37454775,10.1016/j.toxlet.2023.07.011,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Off target toxicities and links with physicochemical properties of medicinal products, including antibiotics, oligonucleotides, lipid nanoparticles (with cationic and/or anionic charges). Data review suggests an emerging pattern.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Off target toxicities and links with physicochemical properties of medicinal products, including antibiotics, oligonucleotides, lipid nanoparticles (with cationic and/or anionic charges). Data review suggests an emerging pattern."
634,1478,37193356,10.1016/j.cotox.2022.100373,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Nephrotoxicity of marketed antisense oligonucleotide drugs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nephrotoxicity of marketed antisense oligonucleotide drugs.
635,1481,35221289,10.1124/dmd.121.000418,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic;risk;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, risk, hepatotoxicity; source title: Adverse Drug Reactions and Toxicity of the Food and Drug Administration-Approved Antisense Oligonucleotide Drugs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Adverse Drug Reactions and Toxicity of the Food and Drug Administration-Approved Antisense Oligonucleotide Drugs.
637,1485,33084520,10.1177/0192623320964391,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Urinary Kidney Biomarker Panel Detects Preclinical Antisense Oligonucleotide-Induced Tubular Toxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Urinary Kidney Biomarker Panel Detects Preclinical Antisense Oligonucleotide-Induced Tubular Toxicity.
638,1488,32833564,10.1089/nat.2020.0867,toxicity,ASO,PubMed abstract sentence 15,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Immunogenicity Assessment of Inotersen, a 2'-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Immunogenicity Assessment of Inotersen, a 2'-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety."
639,1491,31980820,10.1093/nar/gkaa031,chemistry,ASO,PubMed abstract sentence 1,modification;modified;phosphorothioate,"chemistry candidate; matched derived terms: modification, modified, phosphorothioate; source title: Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.
640,1492,31980820,10.1093/nar/gkaa031,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.
642,1496,41879506,10.1177/01926233261430687,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic;risk;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, risk, adverse; source title: Toxicologic Pathology Forum: Opinion on Considerations for Determination of Adverse Versus Nonadverse Nerve Fiber Degeneration in Nonclinical Toxicity Studies of Oligonucleotides Delivered Directly Into the Intrathecal Space.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Toxicologic Pathology Forum: Opinion on Considerations for Determination of Adverse Versus Nonadverse Nerve Fiber Degeneration in Nonclinical Toxicity Studies of Oligonucleotides Delivered Directly Into the Intrathecal Space.
643,1499,41167339,10.1016/j.jconrel.2025.114366,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Incorporation of a polyamine into lipid nanoparticles increases the endosomal release and transfection of nucleic acids without toxicity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Incorporation of a polyamine into lipid nanoparticles increases the endosomal release and transfection of nucleic acids without toxicity.
644,1500,41167339,10.1016/j.jconrel.2025.114366,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Incorporation of a polyamine into lipid nanoparticles increases the endosomal release and transfection of nucleic acids without toxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Incorporation of a polyamine into lipid nanoparticles increases the endosomal release and transfection of nucleic acids without toxicity.
646,1504,40616935,10.1016/j.aquatox.2025.107479,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Vps34 knockdown attenuated AlNPs-induced neurodevelopmental toxicity in zebrafish larvae and adults by inhibiting mitophagy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Vps34 knockdown attenuated AlNPs-induced neurodevelopmental toxicity in zebrafish larvae and adults by inhibiting mitophagy.
648,1508,35917865,10.1016/j.jconrel.2022.07.041,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo.
649,1509,35917865,10.1016/j.jconrel.2022.07.041,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo.
650,1512,34592399,10.1016/j.ijpharm.2021.121140,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines.
651,1513,34592399,10.1016/j.ijpharm.2021.121140,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines.
652,1516,34060347,10.1177/01926233211011615,chemistry,ASO,PubMed abstract sentence 1,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats."
653,1517,34060347,10.1177/01926233211011615,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats."
655,1521,31821125,10.1089/nat.2019.0796,delivery,siRNA,PubMed abstract sentence 1,delivery;conjugated;uptake,"delivery candidate; matched derived terms: delivery, conjugated, uptake; source title: Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis."
656,1522,31821125,10.1089/nat.2019.0796,assay,siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis."
657,1523,31821125,10.1089/nat.2019.0796,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Nonclinical Safety Profile of Revusiran, a 1st-Generation GalNAc-siRNA Conjugate for Treatment of Hereditary Transthyretin-Mediated Amyloidosis."
658,1526,32530964,10.1371/journal.pone.0232603,chemistry,ASO/siRNA,PubMed abstract sentence 2,phosphorothioate;lna,"chemistry candidate; matched derived terms: phosphorothioate, lna; source title: Refining LNA safety profile by controlling phosphorothioate stereochemistry.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Refining LNA safety profile by controlling phosphorothioate stereochemistry.
663,1535,41951857,10.1007/s10565-026-10183-2,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Mechanism of uptake and toxicity of a BCMA antibody drug conjugate with a MMAF payload by nonantigen expressing cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mechanism of uptake and toxicity of a BCMA antibody drug conjugate with a MMAF payload by nonantigen expressing cells.
666,1540,41919735,10.1021/acsabm.5c02525,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Alpha-Tocopherol-Conjugated DNA Tetrahedron with Enhanced Cellular Uptake and Cytotoxicity for Cancer Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Alpha-Tocopherol-Conjugated DNA Tetrahedron with Enhanced Cellular Uptake and Cytotoxicity for Cancer Therapeutics.
667,1543,41898996,10.3390/insects17030334,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Methylene Blue Alleviates Thiamethoxam-Induced Toxicity in Honeybee Larvae by Activating Dihydrolipoyl Dehydrogenase.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Methylene Blue Alleviates Thiamethoxam-Induced Toxicity in Honeybee Larvae by Activating Dihydrolipoyl Dehydrogenase.
668,1546,41883153,10.1002/ptr.70312,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Syringin Protects Against Doxorubicin-Induced Cardiotoxicity via Apelinr-Dependent Activation of the Nuclear Factor-Erythroid 2-Related Factor 2/Heme Oxygenase-1 Antioxidant Pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Syringin Protects Against Doxorubicin-Induced Cardiotoxicity via Apelinr-Dependent Activation of the Nuclear Factor-Erythroid 2-Related Factor 2/Heme Oxygenase-1 Antioxidant Pathway.
669,1549,41874387,10.1152/ajpheart.00944.2025,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi-mediated p38δ silencing mitigates anthracycline cardiotoxicity in female mice.
671,1553,41550911,10.1155/anu/2689798,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Water Added Probiotics Attenuates Sumithion-Induced Toxicity on Growth, Intestinal Deformities, Erythrocytic Abnormalities, and Immunity in Nile Tilapia (Oreochromis niloticus).",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Water Added Probiotics Attenuates Sumithion-Induced Toxicity on Growth, Intestinal Deformities, Erythrocytic Abnormalities, and Immunity in Nile Tilapia (Oreochromis niloticus)."
672,1556,41461418,10.1016/j.pestbp.2025.106889,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Multidimensional toxicity profiling of organophosphorus pesticides in agricultural soils: Target and non-target responses.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Multidimensional toxicity profiling of organophosphorus pesticides in agricultural soils: Target and non-target responses.
673,1559,41446784,10.3389/fphar.2025.1657527,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Phoxim induces neurotoxicity and intestinal damage in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phoxim induces neurotoxicity and intestinal damage in Caenorhabditis elegans.
675,1563,41110164,10.1021/acs.jafc.5c06292,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Multiomics Approaches to Study the Contact Toxicity and Mechanisms of Aliphatic Ketones and Aldehydes against Tribolium castaneum.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Multiomics Approaches to Study the Contact Toxicity and Mechanisms of Aliphatic Ketones and Aldehydes against Tribolium castaneum.
676,1566,41066632,10.1093/hmg/ddaf153,offtarget,ASO,PubMed abstract sentence 5,off-target;transcriptome;hybridization,"offtarget candidate; matched derived terms: off-target, transcriptome, hybridization; source title: Determining off-target effects of splice-switching antisense oligonucleotides using short read RNAseq in neuronally differentiated human induced pluripotent stem cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Determining off-target effects of splice-switching antisense oligonucleotides using short read RNAseq in neuronally differentiated human induced pluripotent stem cells.
677,1569,41065179,10.1021/jacs.5c11823,chemistry,ASO/siRNA,PubMed abstract sentence 5,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Chemical Evolution of Double Covalent Aptamers for Sustained Protein Degradation and Improved Cytotoxicity in NK-Cell-Mediated Tumor Therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical Evolution of Double Covalent Aptamers for Sustained Protein Degradation and Improved Cytotoxicity in NK-Cell-Mediated Tumor Therapy.
678,1570,41065179,10.1021/jacs.5c11823,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chemical Evolution of Double Covalent Aptamers for Sustained Protein Degradation and Improved Cytotoxicity in NK-Cell-Mediated Tumor Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chemical Evolution of Double Covalent Aptamers for Sustained Protein Degradation and Improved Cytotoxicity in NK-Cell-Mediated Tumor Therapy.
679,1573,40983918,10.1186/s12916-025-04359-6,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of GCKIII kinases STK25 and MST3 mitigates organ lipotoxicity and enhances metabolic resilience under nutritional stress.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of GCKIII kinases STK25 and MST3 mitigates organ lipotoxicity and enhances metabolic resilience under nutritional stress.
680,1576,40912822,10.1016/j.carbpol.2025.124049,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic;safety;risk;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, safety, risk, adverse; source title: Novel antibacterial, antioxidant, and anti-inflammatory aminated chitosan hybrid quinoline Schiff base as multi-target agent: Design, molecular docking, and toxicity assessment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Novel antibacterial, antioxidant, and anti-inflammatory aminated chitosan hybrid quinoline Schiff base as multi-target agent: Design, molecular docking, and toxicity assessment."
681,1579,40683240,10.1016/j.envint.2025.109688,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish.
682,1582,40618660,10.1016/j.watres.2025.124128,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bio-promoter-driven conversion of 4-chlorophenol into utilizable carbon source: Enhancing electron supply-consume and attenuating bio-toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bio-promoter-driven conversion of 4-chlorophenol into utilizable carbon source: Enhancing electron supply-consume and attenuating bio-toxicity.
684,1586,40570244,10.1021/acs.est.5c00573,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: High-Throughput Screening Identifies Bisphenol P as a Potent Cardiotoxin, Inducing Cardiotoxicity through Apoptosis and the NF-κB Pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"High-Throughput Screening Identifies Bisphenol P as a Potent Cardiotoxin, Inducing Cardiotoxicity through Apoptosis and the NF-κB Pathway."
686,1590,40376662,10.1039/d5ra01929j,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Exploring N-heterocyclic linked novel hybrid chalcone derivatives: synthesis, characterization, evaluation of antidepressant activity, toxicity assessment, molecular docking, DFT and ADME study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Exploring N-heterocyclic linked novel hybrid chalcone derivatives: synthesis, characterization, evaluation of antidepressant activity, toxicity assessment, molecular docking, DFT and ADME study."
689,1597,38802331,10.1111/bph.16416,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Non-coding RNAs and their potential exploitation in cancer therapy-related cardiotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Non-coding RNAs and their potential exploitation in cancer therapy-related cardiotoxicity.
691,1603,39192097,10.1007/s10120-024-01548-9,chemistry,ASO,PubMed abstract sentence 2,modified;amna,"chemistry candidate; matched derived terms: modified, amna; source title: Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer.
692,1604,39192097,10.1007/s10120-024-01548-9,assay,ASO,PubMed abstract sentence 12,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer.
693,1605,39192097,10.1007/s10120-024-01548-9,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer.
694,1608,39059407,10.1016/S1474-4422(24)00216-3,assay,ASO,PubMed abstract sentence 5,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study."
695,1609,39059407,10.1016/S1474-4422(24)00216-3,toxicity,ASO,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study."
696,1612,38764172,10.1002/ddr.22187,toxicity,ASO,PubMed abstract sentence 6,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Unveiling the potential of antisense oligonucleotides: Mechanisms, therapies, and safety insights.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Unveiling the potential of antisense oligonucleotides: Mechanisms, therapies, and safety insights."
697,1615,38498275,10.1007/s11255-024-03990-1,toxicity,ASO/siRNA,PubMed abstract sentence 6,risk;adverse;renal,"toxicity candidate; matched derived terms: risk, adverse, renal; source title: Ocular and systemic vascular endothelial growth factor ligand inhibitor use and nephrotoxicity: an update.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ocular and systemic vascular endothelial growth factor ligand inhibitor use and nephrotoxicity: an update.
698,1618,38394820,10.1016/j.jcis.2024.02.099,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, uptake; source title: A systematic study of the effect of lipid architecture on cytotoxicity and cellular uptake of cationic cubosomes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A systematic study of the effect of lipid architecture on cytotoxicity and cellular uptake of cationic cubosomes.
700,1620,38394820,10.1016/j.jcis.2024.02.099,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A systematic study of the effect of lipid architecture on cytotoxicity and cellular uptake of cationic cubosomes.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A systematic study of the effect of lipid architecture on cytotoxicity and cellular uptake of cationic cubosomes.
701,1623,37654022,10.1111/cts.13581,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Pharmacokinetics, safety, and tolerability of BMS-986263, a lipid nanoparticle containing HSP47 siRNA, in participants with hepatic impairment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Pharmacokinetics, safety, and tolerability of BMS-986263, a lipid nanoparticle containing HSP47 siRNA, in participants with hepatic impairment."
703,1627,36579950,10.1089/nat.2022.0061,assay,ASO,PubMed abstract sentence 7,assay;preclinical;phase,"assay candidate; matched derived terms: assay, preclinical, phase; source title: Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides.
704,1628,36579950,10.1089/nat.2022.0061,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides.
708,1636,35608030,10.1177/01926233221100414,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Kidney Effects by Alternative Classes of Medicines in Patients and Relationship to Effects in Nonclinical Toxicity Studies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Kidney Effects by Alternative Classes of Medicines in Patients and Relationship to Effects in Nonclinical Toxicity Studies.
710,1642,34575518,10.3390/pharmaceutics13091442,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases."
711,1645,33961089,10.1007/s00204-021-03062-8,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip.
712,1648,33431610,10.1124/jpet.120.000222,chemistry,ASO,PubMed abstract sentence 4,modified;galnac;lna;conjugate,"chemistry candidate; matched derived terms: modified, galnac, lna, conjugate; source title: Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6.",B,high_candidate,curator_verified,accept,derived_annotations_only,"Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6."
713,1649,33431610,10.1124/jpet.120.000222,delivery,ASO,PubMed abstract sentence 2,galnac;uptake,"delivery candidate; matched derived terms: galnac, uptake; source title: Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6."
714,1650,33431610,10.1124/jpet.120.000222,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6."
716,1654,33406986,10.1089/hum.2020.286,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Lack of Toxicity in Nonhuman Primates Receiving Clinically Relevant Doses of an AAV9.U7snRNA Vector Designed to Induce DMD Exon 2 Skipping.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lack of Toxicity in Nonhuman Primates Receiving Clinically Relevant Doses of an AAV9.U7snRNA Vector Designed to Induce DMD Exon 2 Skipping.
717,1657,32865785,10.1007/978-1-0716-0771-8_7,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Degradation of Toxic RNA in Myotonic Dystrophy Using Gapmer Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Degradation of Toxic RNA in Myotonic Dystrophy Using Gapmer Antisense Oligonucleotides.
720,1662,39325927,10.1002/anie.202415272,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Self-Assembled Antibody-Oligonucleotide Conjugates for Targeted Delivery of Complementary Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Self-Assembled Antibody-Oligonucleotide Conjugates for Targeted Delivery of Complementary Antisense Oligonucleotides.
723,1669,37105829,10.1016/j.transproceed.2023.03.062,toxicity,ASO/siRNA,PubMed abstract sentence 1,safety;renal,"toxicity candidate; matched derived terms: safety, renal; source title: Efficacy and Safety of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Therapy for Anemia in Renal Transplantation Patients by Prior Erythropoiesis Stimulating Agent Use.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and Safety of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Therapy for Anemia in Renal Transplantation Patients by Prior Erythropoiesis Stimulating Agent Use.
724,1672,33633318,10.1038/s41598-021-84194-w,toxicity,ASO,PubMed abstract sentence 7,safety;renal,"toxicity candidate; matched derived terms: safety, renal; source title: Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease.
725,1675,42132413,10.1002/jcph.70207,toxicity,ASO,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Pharmacokinetics, Safety, and Tolerability of Anti-miR-17 Oligonucleotide RGLS4326 in Healthy Adult Subjects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Pharmacokinetics, Safety, and Tolerability of Anti-miR-17 Oligonucleotide RGLS4326 in Healthy Adult Subjects."
728,1682,41783787,10.1016/j.omtn.2026.102865,chemistry,siRNA,PubMed abstract sentence 2,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: GalNAc-conjugated siRNA targeting C/EBPβ reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-conjugated siRNA targeting C/EBPβ reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model.
729,1683,41783787,10.1016/j.omtn.2026.102865,delivery,siRNA,PubMed abstract sentence 2,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: GalNAc-conjugated siRNA targeting C/EBPβ reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-conjugated siRNA targeting C/EBPβ reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model.
731,1685,41783787,10.1016/j.omtn.2026.102865,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: GalNAc-conjugated siRNA targeting C/EBPβ reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,GalNAc-conjugated siRNA targeting C/EBPβ reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model.
733,1689,41683454,10.3390/molecules31030476,chemistry,siRNA,PubMed abstract sentence 4,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Refined Design and Liquid-Phase Assembly of GalNAc-siRNA Conjugates: Comparative Efficiency Validation in PCSK9 Targeting.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Refined Design and Liquid-Phase Assembly of GalNAc-siRNA Conjugates: Comparative Efficiency Validation in PCSK9 Targeting.
735,1691,41683454,10.3390/molecules31030476,assay,siRNA,PubMed abstract sentence 9,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Refined Design and Liquid-Phase Assembly of GalNAc-siRNA Conjugates: Comparative Efficiency Validation in PCSK9 Targeting.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Refined Design and Liquid-Phase Assembly of GalNAc-siRNA Conjugates: Comparative Efficiency Validation in PCSK9 Targeting.
737,1695,41076269,10.1016/j.jtha.2025.09.012,assay,ASO/siRNA,PubMed abstract sentence 3,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Preclinical safety and bleeding evaluation in swine for a small interfering RNA-lipid nanoparticle that prevents excess fibrinogen synthesis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical safety and bleeding evaluation in swine for a small interfering RNA-lipid nanoparticle that prevents excess fibrinogen synthesis.
738,1696,41076269,10.1016/j.jtha.2025.09.012,toxicity,ASO/siRNA,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preclinical safety and bleeding evaluation in swine for a small interfering RNA-lipid nanoparticle that prevents excess fibrinogen synthesis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preclinical safety and bleeding evaluation in swine for a small interfering RNA-lipid nanoparticle that prevents excess fibrinogen synthesis.
739,1699,40385635,10.1016/j.omtn.2025.102542,chemistry,siRNA,PubMed abstract sentence 5,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Design, pharmacology, and toxicology of a novel chemically modified siRNA targeting hepatic angiotensinogen.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Design, pharmacology, and toxicology of a novel chemically modified siRNA targeting hepatic angiotensinogen."
742,1704,40179932,10.1016/S0140-6736(25)00507-0,chemistry,siRNA,PubMed abstract sentence 2,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial."
743,1705,40179932,10.1016/S0140-6736(25)00507-0,delivery,siRNA,PubMed abstract sentence 2,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial."
744,1706,40179932,10.1016/S0140-6736(25)00507-0,assay,siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial."
745,1709,37346977,10.1016/j.omtn.2023.05.005,delivery,ASO,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection.
747,1713,37326950,10.1002/npr2.12335,assay,ASO,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial.
748,1716,37200862,10.1016/j.omtn.2023.04.010,offtarget,ASO,PubMed abstract sentence 8,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: Block or degrade? Balancing on- and off-target effects of antisense strategies against transcripts with expanded triplet repeats in DM1.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Block or degrade? Balancing on- and off-target effects of antisense strategies against transcripts with expanded triplet repeats in DM1.
749,1719,36302886,10.1038/s41598-022-23013-2,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Development of lipid nanoparticles and liposomes reference materials (II): cytotoxic profiles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of lipid nanoparticles and liposomes reference materials (II): cytotoxic profiles.
750,1720,36302886,10.1038/s41598-022-23013-2,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of lipid nanoparticles and liposomes reference materials (II): cytotoxic profiles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of lipid nanoparticles and liposomes reference materials (II): cytotoxic profiles.
751,1723,36169577,10.1039/d1nr05644a,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF-α siRNA mitigates gut inflammation via inhibiting the differentiation of CD4(+) T cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF-α siRNA mitigates gut inflammation via inhibiting the differentiation of CD4(+) T cells.
752,1724,36169577,10.1039/d1nr05644a,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF-α siRNA mitigates gut inflammation via inhibiting the differentiation of CD4(+) T cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF-α siRNA mitigates gut inflammation via inhibiting the differentiation of CD4(+) T cells.
753,1727,35921401,10.1021/jacs.2c01679,offtarget,ASO/siRNA,PubMed abstract sentence 7,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Role of a ""Magic"" Methyl: 2'-Deoxy-2'-α-F-2'-β-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Role of a ""Magic"" Methyl: 2'-Deoxy-2'-α-F-2'-β-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects."
755,1733,35737426,10.1093/toxsci/kfac067,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preclinical Toxicological Assessment of A Novel siRNA, SLN360, Targeting Elevated Lipoprotein (a) in Cardiovascular Disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Preclinical Toxicological Assessment of A Novel siRNA, SLN360, Targeting Elevated Lipoprotein (a) in Cardiovascular Disease."
758,1740,34470470,10.4155/bio-2021-0134,chemistry,ASO,PubMed abstract sentence 2,chemical;modification;galnac;lna;conjugate,"chemistry candidate; matched derived terms: chemical, modification, galnac, lna, conjugate; source title: High-sensitivity workflow for LC-MS-based analysis of GalNAc-conjugated oligonucleotides: a case study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-sensitivity workflow for LC-MS-based analysis of GalNAc-conjugated oligonucleotides: a case study.
759,1741,34470470,10.4155/bio-2021-0134,delivery,ASO,PubMed abstract sentence 2,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: High-sensitivity workflow for LC-MS-based analysis of GalNAc-conjugated oligonucleotides: a case study.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-sensitivity workflow for LC-MS-based analysis of GalNAc-conjugated oligonucleotides: a case study.
764,1752,32592692,10.1016/j.ymthe.2020.06.015,chemistry,ASO,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug.
765,1753,32592692,10.1016/j.ymthe.2020.06.015,delivery,ASO,PubMed abstract sentence 1,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug.
768,1760,32160706,10.1016/j.omtn.2020.01.018,delivery,ASO,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo.
769,1761,32160706,10.1016/j.omtn.2020.01.018,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo.
770,1764,41630988,10.1016/j.omtn.2026.102832,chemistry,ASO,PubMed abstract sentence 1,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Identification and functional validation of intracellular protein partners of phosphorothioate splice-switching oligonucleotides using AP-MS.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification and functional validation of intracellular protein partners of phosphorothioate splice-switching oligonucleotides using AP-MS.
777,1779,39190037,10.1007/s00253-024-13283-3,chemistry,ASO,PubMed abstract sentence 7,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Harnessing sulfur-binding domains to separate Sp and Rp isomers of phosphorothioate oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Harnessing sulfur-binding domains to separate Sp and Rp isomers of phosphorothioate oligonucleotides.
778,1782,36028587,10.1208/s12248-022-00741-x,toxicity,ASO,PubMed abstract sentence 6,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Considerations in the Immunogenicity Assessment Strategy for Oligonucleotide Therapeutics (ONTs).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Considerations in the Immunogenicity Assessment Strategy for Oligonucleotide Therapeutics (ONTs).
779,1785,34880218,10.1038/s41467-021-26714-w,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice.",C,high_candidate,curator_rejected,reject,derived_annotations_only,Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice.
781,1789,32246854,10.1002/bmc.4839,chemistry,ASO,PubMed abstract sentence 3,modification;modified,"chemistry candidate; matched derived terms: modification, modified; source title: In vitro metabolism of 2'-ribose unmodified and modified phosphorothioate oligonucleotide therapeutics using liquid chromatography mass spectrometry.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vitro metabolism of 2'-ribose unmodified and modified phosphorothioate oligonucleotide therapeutics using liquid chromatography mass spectrometry.
786,1800,42128917,10.1007/s00204-026-04425-9,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: o-Toluidine and its metabolites induce oxidative and nitrative DNA damage in human urinary bladder epithelial cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,o-Toluidine and its metabolites induce oxidative and nitrative DNA damage in human urinary bladder epithelial cells.
794,1818,41856548,10.1002/jms.70049,assay,ASO,PubMed abstract sentence 2,model;phase,"assay candidate; matched derived terms: model, phase; source title: Characterisation of Antisense Oligonucleotides by Ion-Pair Reversed-Phase UHPLC-HRMS: Method development using Design of Experiments.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Characterisation of Antisense Oligonucleotides by Ion-Pair Reversed-Phase UHPLC-HRMS: Method development using Design of Experiments.
796,1826,41722569,10.1016/j.ajhg.2026.01.016,chemistry,ASO,PubMed abstract sentence 6,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for myotonic dystrophy type 1.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for myotonic dystrophy type 1.
798,1830,41720270,10.1016/j.jconrel.2026.114740,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid nanoparticle (LNP)-mediated cytoplasmic expression of single-stranded DNA and its application in Mpox vaccine.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle (LNP)-mediated cytoplasmic expression of single-stranded DNA and its application in Mpox vaccine.
800,1834,41629746,10.1002/1744-9987.70121,toxicity,ASO/siRNA,PubMed abstract sentence 4,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Plasma Exchange for Anti-GBM Disease With Dialysis Dependency: A Case Series on Clinical Outcomes and Safety.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Plasma Exchange for Anti-GBM Disease With Dialysis Dependency: A Case Series on Clinical Outcomes and Safety.
801,1837,41620194,10.1016/j.actbio.2026.01.055,delivery,siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid nanoparticle-mediated Cd14 siRNA delivery ameliorates the acute inflammatory response to intracortical microelectrode implantation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle-mediated Cd14 siRNA delivery ameliorates the acute inflammatory response to intracortical microelectrode implantation.
803,1841,41546392,10.1080/15257770.2026.2615355,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Design, synthesis, and biological properties of novel metabolizable pH-responsive lipids for use in lipid nanoparticles for siRNA delivery and mRNA vaccination.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Design, synthesis, and biological properties of novel metabolizable pH-responsive lipids for use in lipid nanoparticles for siRNA delivery and mRNA vaccination."
804,1842,41546392,10.1080/15257770.2026.2615355,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Design, synthesis, and biological properties of novel metabolizable pH-responsive lipids for use in lipid nanoparticles for siRNA delivery and mRNA vaccination.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Design, synthesis, and biological properties of novel metabolizable pH-responsive lipids for use in lipid nanoparticles for siRNA delivery and mRNA vaccination."
805,1845,41442838,10.1016/j.cyto.2025.157098,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Advances in lipid nanoparticle delivery systems for targeted cytokine immunotherapy in autoimmune disorders.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in lipid nanoparticle delivery systems for targeted cytokine immunotherapy in autoimmune disorders.
806,1846,41442838,10.1016/j.cyto.2025.157098,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advances in lipid nanoparticle delivery systems for targeted cytokine immunotherapy in autoimmune disorders.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in lipid nanoparticle delivery systems for targeted cytokine immunotherapy in autoimmune disorders.
808,1854,41407269,10.1016/j.ophtha.2025.12.011,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Avacincaptad Pegol for Geographic Atrophy Secondary to Age-Related Macular Degeneration: Two-Year Efficacy and Safety Results from the GATHER2 Phase 3 Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Avacincaptad Pegol for Geographic Atrophy Secondary to Age-Related Macular Degeneration: Two-Year Efficacy and Safety Results from the GATHER2 Phase 3 Trial.
810,1858,41406692,10.1016/j.talanta.2025.129237,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aptamer-based biosensing platforms for saxitoxin and tetrodotoxin: Advances, challenges, and future perspectives in food safety and environmental monitoring.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Aptamer-based biosensing platforms for saxitoxin and tetrodotoxin: Advances, challenges, and future perspectives in food safety and environmental monitoring."
815,1867,41338505,10.1016/j.ijbiomac.2025.149419,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Glutamine modified lipid nanoparticles loaded with GPX4 siRNA for cervical cancer targeting.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Glutamine modified lipid nanoparticles loaded with GPX4 siRNA for cervical cancer targeting.
818,1878,41283704,10.1021/acs.jmedchem.5c02209,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2(+) Breast Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2(+) Breast Cancer.
819,1879,41283704,10.1021/acs.jmedchem.5c02209,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2(+) Breast Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dually Decorated Palmitate-Containing Lipid Nanoparticles for the Targeted Delivery of siRNAs against HER2 and Hsp27 in HER2(+) Breast Cancer.
820,1882,41275652,10.1016/j.jhazmat.2025.140563,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Silencing of the endoplasmic reticulum stress sensor IRE1 impairs survival and growth of zooplankton under toxic cyanobacteria.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing of the endoplasmic reticulum stress sensor IRE1 impairs survival and growth of zooplankton under toxic cyanobacteria.
824,1890,41183892,10.1248/bpb.b25-00229,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Treatment of Experimental Autoimmune Encephalomyelitis with Lipid Nanoparticles Loaded with siRNA Targeting Neogenin.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Treatment of Experimental Autoimmune Encephalomyelitis with Lipid Nanoparticles Loaded with siRNA Targeting Neogenin.
827,1895,41111811,10.7759/cureus.92446,toxicity,ASO/siRNA,PubMed abstract sentence 4,adverse;renal,"toxicity candidate; matched derived terms: adverse, renal; source title: Efficacy and Safety of Zilebesiran for the Management of Hypertension: An Updated Systematic Review and Meta-Analysis of Randomised Controlled Trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and Safety of Zilebesiran for the Management of Hypertension: An Updated Systematic Review and Meta-Analysis of Randomised Controlled Trials.
828,1898,41094680,10.1186/s12933-025-02929-9,toxicity,ASO/siRNA,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Safety, pharmacokinetics and pharmacodynamics of Plozasiran in Chinese healthy volunteers.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety, pharmacokinetics and pharmacodynamics of Plozasiran in Chinese healthy volunteers."
829,1901,41071927,10.1021/acsami.5c13954,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid Nanoparticle-Mediated Targeted Delivery of MEGF10 siRNA to Astrocytes Reduced Synaptic Phagocytosis and Promoted Stroke Recovery in Mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticle-Mediated Targeted Delivery of MEGF10 siRNA to Astrocytes Reduced Synaptic Phagocytosis and Promoted Stroke Recovery in Mice.
837,1919,40776451,10.1002/adhm.202500695,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: nanoparticle, lnp, uptake; source title: Pulmonary Delivery of siRNA Anti-TNFα-loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pulmonary Delivery of siRNA Anti-TNFα-loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury.
846,1946,40091434,10.1002/adma.202419538,delivery,ASO,PubMed abstract sentence 4,delivery;lnp;uptake,"delivery candidate; matched derived terms: delivery, lnp, uptake; source title: Formulation and Characterization of Novel Ionizable and Cationic Lipid Nanoparticles for the Delivery of Splice-Switching Oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Formulation and Characterization of Novel Ionizable and Cationic Lipid Nanoparticles for the Delivery of Splice-Switching Oligonucleotides.
847,1947,40091434,10.1002/adma.202419538,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Formulation and Characterization of Novel Ionizable and Cationic Lipid Nanoparticles for the Delivery of Splice-Switching Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Formulation and Characterization of Novel Ionizable and Cationic Lipid Nanoparticles for the Delivery of Splice-Switching Oligonucleotides.
849,1957,39861693,10.3390/pharmaceutics17010045,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Innovative Lipid Nanoparticles Co-Delivering Hydroxychloroquine and siRNA for Enhanced Rheumatoid Arthritis Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Innovative Lipid Nanoparticles Co-Delivering Hydroxychloroquine and siRNA for Enhanced Rheumatoid Arthritis Therapy.
852,1964,39293936,10.1111/bph.17302,offtarget,ASO/siRNA,PubMed abstract sentence 5,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: Mitigating off-target effects of small RNAs: conventional approaches, network theory and artificial intelligence.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Mitigating off-target effects of small RNAs: conventional approaches, network theory and artificial intelligence."
854,1970,39670497,10.2174/0122117385330006241120084721,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: A Critical Review on Lipid Nanoparticle-based siRNA Formulations for Breast Cancer Management.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Critical Review on Lipid Nanoparticle-based siRNA Formulations for Breast Cancer Management.
855,1973,39592778,10.1038/s41598-024-80559-z,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Functional profiling of the rhizospheric Exiguobacterium sp. for dimethoate degradation, PGPR activity, biofilm development, and ecotoxicological risk.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Functional profiling of the rhizospheric Exiguobacterium sp. for dimethoate degradation, PGPR activity, biofilm development, and ecotoxicological risk."
857,1977,39495988,10.1097/MD.0000000000040110,toxicity,ASO,PubMed abstract sentence 18,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Clinical efficacy evaluation and safety study of Qishen Tongmai Yin I combined with moxibustion therapy on ASO: A retrospective study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Clinical efficacy evaluation and safety study of Qishen Tongmai Yin I combined with moxibustion therapy on ASO: A retrospective study.
858,1980,39407291,10.1186/s12967-024-05711-9,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Innovative nebulization delivery of lipid nanoparticle-encapsulated siRNA: a therapeutic advance for Staphylococcus aureus-induced pneumonia.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Innovative nebulization delivery of lipid nanoparticle-encapsulated siRNA: a therapeutic advance for Staphylococcus aureus-induced pneumonia.
860,1984,39363681,10.1002/adhm.202401868,delivery,ASO,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Oligonucleotide-Linked Lipid Nanoparticles as a Versatile mRNA Nanovaccine Platform.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oligonucleotide-Linked Lipid Nanoparticles as a Versatile mRNA Nanovaccine Platform.
861,1987,39304746,10.1038/s41416-024-02859-5,chemistry,ASO,PubMed abstract sentence 2,modified;amna,"chemistry candidate; matched derived terms: modified, amna; source title: Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer.
870,2008,39254274,10.1002/adhm.202402219,delivery,siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS-induced Depressive-Like Behaviors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS-induced Depressive-Like Behaviors.
872,2012,39163541,10.1021/acs.accounts.4c00348,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Heavy Metal-Based Toxic Oxo-Pollutants Sequestration by Advanced Functional Porous Materials for Safe Drinking Water.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Heavy Metal-Based Toxic Oxo-Pollutants Sequestration by Advanced Functional Porous Materials for Safe Drinking Water.
879,2031,39041663,10.1080/17576180.2024.2368339,delivery,ASO,PubMed abstract sentence 1,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Bioanalysis of free antisense oligonucleotide payload from antibody-oligonucleotide conjugate by hybridization LC-MS/MS.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Bioanalysis of free antisense oligonucleotide payload from antibody-oligonucleotide conjugate by hybridization LC-MS/MS.
881,2035,38993932,10.1016/j.omtn.2024.102237,offtarget,ASO,PubMed abstract sentence 8,mismatch;silencing,"offtarget candidate; matched derived terms: mismatch, silencing; source title: Strategies to improve the design of gapmer antisense oligonucleotide on allele-specific silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Strategies to improve the design of gapmer antisense oligonucleotide on allele-specific silencing.
884,2040,38983605,10.1016/j.crtox.2024.100182,assay,ASO,PubMed abstract sentence 10,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Comprehensive review of adverse reactions and toxicology in ASO-based therapies for Duchenne Muscular Dystrophy: From FDA-approved drugs to peptide-conjugated ASO.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comprehensive review of adverse reactions and toxicology in ASO-based therapies for Duchenne Muscular Dystrophy: From FDA-approved drugs to peptide-conjugated ASO.
885,2041,38983605,10.1016/j.crtox.2024.100182,toxicity,ASO,PubMed abstract sentence 9,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: Comprehensive review of adverse reactions and toxicology in ASO-based therapies for Duchenne Muscular Dystrophy: From FDA-approved drugs to peptide-conjugated ASO.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comprehensive review of adverse reactions and toxicology in ASO-based therapies for Duchenne Muscular Dystrophy: From FDA-approved drugs to peptide-conjugated ASO.
886,2044,38976350,10.1021/acs.est.4c01153,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Perfluorooctane Sulfonamide Induced Autotoxic Effects on the Zebrafish Immune System.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Perfluorooctane Sulfonamide Induced Autotoxic Effects on the Zebrafish Immune System.
887,2047,38972640,10.1016/j.jconrel.2024.07.011,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipid nanoparticle-mediated hepatocyte delivery of siRNA and silibinin in metabolic dysfunction-associated steatotic liver disease.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle-mediated hepatocyte delivery of siRNA and silibinin in metabolic dysfunction-associated steatotic liver disease.
890,2052,38893532,10.3390/molecules29112658,delivery,ASO,PubMed abstract sentence 7,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Potential of Cell-Penetrating Peptide-Conjugated Antisense Oligonucleotides for the Treatment of SMA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Potential of Cell-Penetrating Peptide-Conjugated Antisense Oligonucleotides for the Treatment of SMA.
894,2064,38749176,10.1016/j.biopha.2024.116737,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide.
895,2071,38636882,10.1016/j.ejpb.2024.114296,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: A potent bioreducible ionizable lipid nanoparticle enables siRNA delivery for retinal neovascularization inhibition.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A potent bioreducible ionizable lipid nanoparticle enables siRNA delivery for retinal neovascularization inhibition.
902,2088,38436880,10.1007/s11302-024-09989-8,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells.
907,2103,38010230,10.1089/nat.2023.0038,chemistry,ASO,PubMed abstract sentence 3,chemical;modified;phosphorothioate;2'-o;lna,"chemistry candidate; matched derived terms: chemical, modified, phosphorothioate, 2'-o, lna; source title: Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy.
911,2109,37995087,10.1007/s40261-023-01320-4,toxicity,ASO/siRNA,PubMed abstract sentence 17,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Safety Concerns with Nusinersen, Risdiplam, and Onasemnogene Abeparvovec in Spinal Muscular Atrophy: A Real-World Pharmacovigilance Study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Safety Concerns with Nusinersen, Risdiplam, and Onasemnogene Abeparvovec in Spinal Muscular Atrophy: A Real-World Pharmacovigilance Study."
912,2112,37830609,10.3390/cells12192395,delivery,ASO,PubMed abstract sentence 5,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Enhancing Antisense Oligonucleotide-Based Therapeutic Delivery with DG9, a Versatile Cell-Penetrating Peptide.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Enhancing Antisense Oligonucleotide-Based Therapeutic Delivery with DG9, a Versatile Cell-Penetrating Peptide."
913,2113,37830609,10.3390/cells12192395,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhancing Antisense Oligonucleotide-Based Therapeutic Delivery with DG9, a Versatile Cell-Penetrating Peptide.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Enhancing Antisense Oligonucleotide-Based Therapeutic Delivery with DG9, a Versatile Cell-Penetrating Peptide."
914,2116,37429729,10.1124/dmd.123.001370,chemistry,ASO,PubMed abstract sentence 2,phosphorothioate;galnac;lna;conjugate,"chemistry candidate; matched derived terms: phosphorothioate, galnac, lna, conjugate; source title: In Vivo Metabolite Profiles of an N-Acetylgalactosamine-Conjugated Antisense Oligonucleotide AZD8233 Using Liquid Chromatography High-Resolution Mass Spectrometry: A Cross-Species Comparison in Animals and Humans.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vivo Metabolite Profiles of an N-Acetylgalactosamine-Conjugated Antisense Oligonucleotide AZD8233 Using Liquid Chromatography High-Resolution Mass Spectrometry: A Cross-Species Comparison in Animals and Humans.
915,2117,37429729,10.1124/dmd.123.001370,delivery,ASO,PubMed abstract sentence 2,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: In Vivo Metabolite Profiles of an N-Acetylgalactosamine-Conjugated Antisense Oligonucleotide AZD8233 Using Liquid Chromatography High-Resolution Mass Spectrometry: A Cross-Species Comparison in Animals and Humans.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vivo Metabolite Profiles of an N-Acetylgalactosamine-Conjugated Antisense Oligonucleotide AZD8233 Using Liquid Chromatography High-Resolution Mass Spectrometry: A Cross-Species Comparison in Animals and Humans.
917,2123,37207382,10.1016/j.nmd.2023.03.008,toxicity,ASO/siRNA,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Safety, tolerability and pharmacokinetics of eteplirsen in young boys aged 6-48 months with Duchenne muscular dystrophy amenable to exon 51 skipping.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety, tolerability and pharmacokinetics of eteplirsen in young boys aged 6-48 months with Duchenne muscular dystrophy amenable to exon 51 skipping."
918,2126,37077890,10.3389/fgeed.2023.1034720,assay,ASO/siRNA,PubMed abstract sentence 1,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: CRISPR/Cas9-generated mouse model with humanizing single-base substitution in the Gnao1 for safety studies of RNA therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CRISPR/Cas9-generated mouse model with humanizing single-base substitution in the Gnao1 for safety studies of RNA therapeutics.
923,2137,36853144,10.1021/acsbiomaterials.2c00669,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Safety and Biodistribution of Nanoligomers Targeting the SARS-CoV-2 Genome for the Treatment of COVID-19.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety and Biodistribution of Nanoligomers Targeting the SARS-CoV-2 Genome for the Treatment of COVID-19.
924,2140,36602748,10.1007/s40801-022-00348-w,assay,ASO/siRNA,PubMed abstract sentence 19,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Safety and Effectiveness of Lenvatinib in Patients with Unresectable Hepatocellular Carcinoma in Real-World Clinical Practice: An Observational Post-Marketing Study in Japan.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Safety and Effectiveness of Lenvatinib in Patients with Unresectable Hepatocellular Carcinoma in Real-World Clinical Practice: An Observational Post-Marketing Study in Japan.
925,2141,36602748,10.1007/s40801-022-00348-w,toxicity,ASO/siRNA,PubMed abstract sentence 7,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Safety and Effectiveness of Lenvatinib in Patients with Unresectable Hepatocellular Carcinoma in Real-World Clinical Practice: An Observational Post-Marketing Study in Japan.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety and Effectiveness of Lenvatinib in Patients with Unresectable Hepatocellular Carcinoma in Real-World Clinical Practice: An Observational Post-Marketing Study in Japan.
926,2144,36521639,10.1016/j.ijpharm.2022.122489,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Engineered ionizable lipid nanoparticles mediated efficient siRNA delivery to macrophages for anti-inflammatory treatment of acute liver injury.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered ionizable lipid nanoparticles mediated efficient siRNA delivery to macrophages for anti-inflammatory treatment of acute liver injury.
927,2145,36521639,10.1016/j.ijpharm.2022.122489,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineered ionizable lipid nanoparticles mediated efficient siRNA delivery to macrophages for anti-inflammatory treatment of acute liver injury.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineered ionizable lipid nanoparticles mediated efficient siRNA delivery to macrophages for anti-inflammatory treatment of acute liver injury.
929,2151,36464085,10.1016/j.mad.2022.111759,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic.
931,2159,36397636,10.1016/j.jconrel.2022.10.050,toxicity,ASO,PubMed abstract sentence 4,adverse;renal,"toxicity candidate; matched derived terms: adverse, renal; source title: Nano drug delivery systems for antisense oligonucleotides (ASO) therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nano drug delivery systems for antisense oligonucleotides (ASO) therapeutics.
933,2165,36191773,10.1016/j.actbio.2022.09.065,delivery,siRNA,PubMed abstract sentence 7,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Development of amino acid-modified biodegradable lipid nanoparticles for siRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of amino acid-modified biodegradable lipid nanoparticles for siRNA delivery.
934,2166,36191773,10.1016/j.actbio.2022.09.065,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of amino acid-modified biodegradable lipid nanoparticles for siRNA delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of amino acid-modified biodegradable lipid nanoparticles for siRNA delivery.
935,2169,36126785,10.1016/j.jconrel.2022.09.021,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery.
937,2173,36090761,10.1016/j.omtn.2022.07.027,chemistry,ASO,PubMed abstract sentence 3,modified;lna,"chemistry candidate; matched derived terms: modified, lna; source title: Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.
938,2176,35908242,10.1007/s00415-022-11276-8,toxicity,ASO/siRNA,PubMed abstract sentence 13,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Long-term efficacy and safety of inotersen for hereditary transthyretin amyloidosis: NEURO-TTR open-label extension 3-year update.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Long-term efficacy and safety of inotersen for hereditary transthyretin amyloidosis: NEURO-TTR open-label extension 3-year update.
946,2196,35561842,10.1016/j.bcp.2022.115080,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging."
947,2203,35208958,10.3390/molecules27041170,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Effect of Cationic Lipid Nanoparticle Loaded siRNA with Stearylamine against Chikungunya Virus.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of Cationic Lipid Nanoparticle Loaded siRNA with Stearylamine against Chikungunya Virus.
949,2211,34797383,10.1007/s00204-021-03184-z,assay,ASO/siRNA,PubMed abstract sentence 11,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Pharmacology and toxicology of eteplirsen and SRP-5051 for DMD exon 51 skipping: an update.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pharmacology and toxicology of eteplirsen and SRP-5051 for DMD exon 51 skipping: an update.
950,2212,34797383,10.1007/s00204-021-03184-z,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pharmacology and toxicology of eteplirsen and SRP-5051 for DMD exon 51 skipping: an update.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pharmacology and toxicology of eteplirsen and SRP-5051 for DMD exon 51 skipping: an update.
951,2215,34788571,10.1089/nat.2021.0043,assay,ASO/siRNA,PubMed abstract sentence 1,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Long-Term Safety and Efficacy Data of Golodirsen in Ambulatory Patients with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping: A First-in-human, Multicenter, Two-Part, Open-Label, Phase 1/2 Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Long-Term Safety and Efficacy Data of Golodirsen in Ambulatory Patients with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping: A First-in-human, Multicenter, Two-Part, Open-Label, Phase 1/2 Trial."
952,2216,34788571,10.1089/nat.2021.0043,toxicity,ASO/siRNA,PubMed abstract sentence 8,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Long-Term Safety and Efficacy Data of Golodirsen in Ambulatory Patients with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping: A First-in-human, Multicenter, Two-Part, Open-Label, Phase 1/2 Trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Long-Term Safety and Efficacy Data of Golodirsen in Ambulatory Patients with Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping: A First-in-human, Multicenter, Two-Part, Open-Label, Phase 1/2 Trial."
953,2219,35423918,10.1039/d1ra00878a,chemistry,ASO,PubMed abstract sentence 4,modified;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: modified, phosphorothioate, 2'-o; source title: Evaluation of DNA segments in 2'-modified RNA sequences in designing efficient splice switching antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of DNA segments in 2'-modified RNA sequences in designing efficient splice switching antisense oligonucleotides.
954,2222,34832896,10.3390/ph14111113,chemistry,ASO,PubMed abstract sentence 5,modified;lna,"chemistry candidate; matched derived terms: modified, lna; source title: Intramuscular Evaluation of Chimeric Locked Nucleic Acid/2'OMethyl-Modified Antisense Oligonucleotides for Targeted Exon 23 Skipping in Mdx Mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intramuscular Evaluation of Chimeric Locked Nucleic Acid/2'OMethyl-Modified Antisense Oligonucleotides for Targeted Exon 23 Skipping in Mdx Mice.
956,2226,34760338,10.1016/j.omtn.2021.10.008,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides.
957,2229,34757287,10.1016/j.dmpk.2021.100424,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs.
958,2234,34683974,10.3390/pharmaceutics13101681,delivery,siRNA,PubMed abstract sentence 6,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia.
959,2237,34629736,10.1293/tox.2021-0007,toxicity,ASO,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Karnovsky's fixative prevents artifacts appearing as vacuolation derived from tissue processing in kidneys treated with antisense oligonucleotide.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Karnovsky's fixative prevents artifacts appearing as vacuolation derived from tissue processing in kidneys treated with antisense oligonucleotide.
961,2245,34105177,10.1002/mus.27347,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial."
962,2246,34105177,10.1002/mus.27347,toxicity,ASO/siRNA,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial."
965,2253,34042551,10.1080/10717544.2021.1928794,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: cRGD peptide-conjugated polyethylenimine-based lipid nanoparticle for intracellular delivery of siRNA in hepatocarcinoma therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,cRGD peptide-conjugated polyethylenimine-based lipid nanoparticle for intracellular delivery of siRNA in hepatocarcinoma therapy.
967,2259,33899154,10.1007/s00415-021-10569-8,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxic;renal,"toxicity candidate; matched derived terms: toxic, renal; source title: Nusinersen treatment in adult patients with spinal muscular atrophy: a safety analysis of laboratory parameters.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Nusinersen treatment in adult patients with spinal muscular atrophy: a safety analysis of laboratory parameters.
970,2268,33738134,10.1016/j.omtn.2021.02.007,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.
971,2269,33738134,10.1016/j.omtn.2021.02.007,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.
972,2272,33626278,10.1021/jacs.0c12043,delivery,ASO,PubMed abstract sentence 2,conjugated;uptake,"delivery candidate; matched derived terms: conjugated, uptake; source title: Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell.
975,2285,33096948,10.1080/10717544.2020.1827085,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy.
976,2286,33096948,10.1080/10717544.2020.1827085,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy.
977,2291,32865780,10.1007/978-1-0716-0771-8_2,assay,ASO,PubMed abstract sentence 8,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Development and Clinical Applications of Antisense Oligonucleotide Gapmers.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development and Clinical Applications of Antisense Oligonucleotide Gapmers.
979,2301,32343462,10.1111/ene.14285,toxicity,ASO/siRNA,PubMed abstract sentence 6,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Early data on long-term efficacy and safety of inotersen in patients with hereditary transthyretin amyloidosis: a 2-year update from the open-label extension of the NEURO-TTR trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Early data on long-term efficacy and safety of inotersen in patients with hereditary transthyretin amyloidosis: a 2-year update from the open-label extension of the NEURO-TTR trial.
980,2306,31873063,10.1089/nat.2019.0811,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;lna,"chemistry candidate; matched derived terms: modified, lna; source title: Systemic Evaluation of Chimeric LNA/2'-O-Methyl Steric Blockers for Myotonic Dystrophy Type 1 Therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Systemic Evaluation of Chimeric LNA/2'-O-Methyl Steric Blockers for Myotonic Dystrophy Type 1 Therapy.
984,2320,42104888,10.2533/chimia.2026.222,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Properties of Stereopure Phosphorothioate Groups in RNA-PROTACs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Properties of Stereopure Phosphorothioate Groups in RNA-PROTACs.
994,2348,41867107,10.1021/acsinfecdis.6c00013,chemistry,ASO/siRNA,PubMed abstract sentence 3,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Phosphorothioate Modification-Regulated One-Pot CRISPR Assay for Arbovirus Detection.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phosphorothioate Modification-Regulated One-Pot CRISPR Assay for Arbovirus Detection.
1001,2363,41761314,10.1186/s12951-026-04098-7,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration.
1010,2386,41676392,10.3389/fpls.2025.1720420,offtarget,ASO/siRNA,PubMed abstract sentence 5,transcriptome;unintended,"offtarget candidate; matched derived terms: transcriptome, unintended; source title: Using transcriptome analysis to evaluate the impact of dsAllim cotton on non-target organism O. similis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Using transcriptome analysis to evaluate the impact of dsAllim cotton on non-target organism O. similis.
1011,2389,41647638,10.3389/fpls.2025.1629727,offtarget,ASO/siRNA,PubMed abstract sentence 8,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: Silencing of a glycosyltransferase-like protein in citrus reduces male and female fertility impacting seed development in self-pollinated fruit.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing of a glycosyltransferase-like protein in citrus reduces male and female fertility impacting seed development in self-pollinated fruit.
1012,2392,41201497,10.1016/j.jare.2025.10.044,delivery,siRNA,PubMed abstract sentence 10,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: RNAI-based strategies and nanomaterial-mediated delivery for green control of clubroot disease in rapeseed.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAI-based strategies and nanomaterial-mediated delivery for green control of clubroot disease in rapeseed.
1014,2394,41201497,10.1016/j.jare.2025.10.044,offtarget,siRNA,PubMed abstract sentence 8,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: RNAI-based strategies and nanomaterial-mediated delivery for green control of clubroot disease in rapeseed.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAI-based strategies and nanomaterial-mediated delivery for green control of clubroot disease in rapeseed.
1015,2397,40926402,10.1021/acs.bioconjchem.5c00242,chemistry,ASO/siRNA,PubMed abstract sentence 4,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Phosphorothioate-Modified DNA Aptamer-Based PROTACs for Targeted Degradation of Estrogen Receptor α.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phosphorothioate-Modified DNA Aptamer-Based PROTACs for Targeted Degradation of Estrogen Receptor α.
1018,2404,40492356,10.1002/asia.202401696,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Cellular Inflammation-Induced Cleavage of Phosphorothioate DNA Locker Activates CRISPR/Cas9 Regulator for Gene Editing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cellular Inflammation-Induced Cleavage of Phosphorothioate DNA Locker Activates CRISPR/Cas9 Regulator for Gene Editing.
1019,2407,40258523,10.1016/j.freeradbiomed.2025.04.027,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Excision repair cross complementation group 1 gene exon 3 skipping isoform presents selective cGAS-STING activation in platinum-sensitive lung adenocarcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Excision repair cross complementation group 1 gene exon 3 skipping isoform presents selective cGAS-STING activation in platinum-sensitive lung adenocarcinoma.
1032,2440,38767870,10.4081/aiua.2024.12389,toxicity,ASO/siRNA,PubMed abstract sentence 2,risk;renal,"toxicity candidate; matched derived terms: risk, renal; source title: Pediatric renal transplantation: a single center experience.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pediatric renal transplantation: a single center experience.
1033,2443,38740457,10.1016/j.aca.2024.342649,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Phosphorothioate-modified G-quadruplex as a signal-on dual-mode reporter for CRISPR/Cas12a-based portable detection of environmental pollutants.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phosphorothioate-modified G-quadruplex as a signal-on dual-mode reporter for CRISPR/Cas12a-based portable detection of environmental pollutants.
1034,2446,38587587,10.1007/s43440-024-00592-7,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives."
1036,2452,36589712,10.1016/j.omtn.2022.11.024,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines."
1038,2456,35904033,10.1161/HYPERTENSIONAHA.122.18731,toxicity,ASO/siRNA,PubMed abstract sentence 10,safety;renal,"toxicity candidate; matched derived terms: safety, renal; source title: Angiotensinogen Suppression: A New Tool to Treat Cardiovascular and Renal Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Angiotensinogen Suppression: A New Tool to Treat Cardiovascular and Renal Disease.
1042,2466,33285320,10.1016/j.cbpc.2020.108946,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transcriptome analysis of cadmium exposure in kidney fibroblast cells of the North Atlantic Right Whale (Eubalaena glacialis).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transcriptome analysis of cadmium exposure in kidney fibroblast cells of the North Atlantic Right Whale (Eubalaena glacialis).
1045,2473,32202774,10.1021/jacs.9b13524,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modification;phosphorothioate,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate; source title: Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.
1048,2484,42159020,,assay,ASO/siRNA,PubMed abstract sentence 5,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: [New therapies and ongoing clinical trials in Alzheimer's disease].",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,[New therapies and ongoing clinical trials in Alzheimer's disease].
1054,2502,42052678,10.1039/d5tb02880a,chemistry,ASO,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Impact of 2'-fluoro nucleobase modifications on CD detection, sensitivity and specificity of short oligonucleotides bound to alginate hydrogels.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Impact of 2'-fluoro nucleobase modifications on CD detection, sensitivity and specificity of short oligonucleotides bound to alginate hydrogels."
1056,2506,42045944,10.1186/s12951-026-04423-0,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticles for bone marrow-targeted RNA therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles for bone marrow-targeted RNA therapeutics.
1060,2518,41956189,10.1016/j.ijbiomac.2026.151876,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Facilitating siRNA delivery into mammalian cells via the LDL receptor.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Facilitating siRNA delivery into mammalian cells via the LDL receptor.
1064,2534,41859644,10.1016/j.mtbio.2026.102999,delivery,siRNA,PubMed abstract sentence 2,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: An exosome-biomimetic photothermal nanocarrier for IGF2BP2 siRNA delivery and enhanced ferroptosis in head and neck squamous cell carcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,An exosome-biomimetic photothermal nanocarrier for IGF2BP2 siRNA delivery and enhanced ferroptosis in head and neck squamous cell carcinoma.
1066,2538,41832714,10.2174/0113816128410562251204115232,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, uptake; source title: Advances in siRNA-Loaded Nanocarriers: Harnessing Cutting-Edge Technologies for Precision Cancer Treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in siRNA-Loaded Nanocarriers: Harnessing Cutting-Edge Technologies for Precision Cancer Treatment.
1067,2541,41810472,10.1016/j.ajps.2026.101121,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: The evolution of lipid nanoparticles: Paving the way for next-generation nucleic acid medicines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The evolution of lipid nanoparticles: Paving the way for next-generation nucleic acid medicines.
1068,2544,41809386,10.1016/j.mtbio.2026.102991,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Transdermal siRNA delivery via biomineralized nanoparticle-incorporated microneedles modulates cuproptosis-ferroptosis interaction for psoriasis therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transdermal siRNA delivery via biomineralized nanoparticle-incorporated microneedles modulates cuproptosis-ferroptosis interaction for psoriasis therapy.
1070,2548,41809385,10.1016/j.mtbio.2026.102981,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Polysaccharide-functionalized gold, silver, and iron oxide nanoparticles for siRNA delivery: The role of artificial intelligence in design and optimization.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Polysaccharide-functionalized gold, silver, and iron oxide nanoparticles for siRNA delivery: The role of artificial intelligence in design and optimization."
1072,2552,41797405,10.1021/acsnano.5c16693,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lung-Accumulating Mucin 5AC Silencing by Noninflammatory Lipid Nanoparticles for Asthma Treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lung-Accumulating Mucin 5AC Silencing by Noninflammatory Lipid Nanoparticles for Asthma Treatment.
1074,2556,41792170,10.1038/s41467-026-70349-8,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Tudor domain-containing protein 9-targeting siRNA nanoparticles alleviate Pseudomonas aeruginosa lung injury in preclinical models by promoting neutrophil cuproptosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tudor domain-containing protein 9-targeting siRNA nanoparticles alleviate Pseudomonas aeruginosa lung injury in preclinical models by promoting neutrophil cuproptosis.
1077,2561,41780686,10.1016/j.jconrel.2026.114749,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A functional lyoprotectant platform enables storage-stable, mucus-penetrating siRNA delivery to the lung.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A functional lyoprotectant platform enables storage-stable, mucus-penetrating siRNA delivery to the lung."
1079,2565,41780418,10.1016/j.jcyt.2025.102044,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticle-points to consider in assessing materials quality for ribonucleic acid-based therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle-points to consider in assessing materials quality for ribonucleic acid-based therapeutics.
1085,2579,41755009,10.3390/pharmaceutics18020268,delivery,siRNA,PubMed abstract sentence 10,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Calcium/Aluminum-Cored Asymmetric Bilayer Nanoparticles for Codelivery of Ziyuglycoside II and PD-L1 siRNA Exert Anti-Breast Tumor Effects.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Calcium/Aluminum-Cored Asymmetric Bilayer Nanoparticles for Codelivery of Ziyuglycoside II and PD-L1 siRNA Exert Anti-Breast Tumor Effects.
1086,2580,41755009,10.3390/pharmaceutics18020268,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Calcium/Aluminum-Cored Asymmetric Bilayer Nanoparticles for Codelivery of Ziyuglycoside II and PD-L1 siRNA Exert Anti-Breast Tumor Effects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Calcium/Aluminum-Cored Asymmetric Bilayer Nanoparticles for Codelivery of Ziyuglycoside II and PD-L1 siRNA Exert Anti-Breast Tumor Effects.
1087,2585,41723880,10.1111/bph.70330,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Reprogramming tumour-associated macrophages in breast cancer via si-FOXM1-loaded lipid nanoparticles enhances immune checkpoint inhibitor efficacy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Reprogramming tumour-associated macrophages in breast cancer via si-FOXM1-loaded lipid nanoparticles enhances immune checkpoint inhibitor efficacy.
1097,2609,41596367,10.3390/ijms27020717,assay,siRNA,PubMed abstract sentence 5,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Small Interfering RNA (siRNA) as a Targeted Therapy for Acute Respiratory Distress Syndrome: Evidence from Experimental Models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Small Interfering RNA (siRNA) as a Targeted Therapy for Acute Respiratory Distress Syndrome: Evidence from Experimental Models.
1099,2619,41570670,10.1016/j.biomaterials.2026.124002,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Transforming lipid nanoparticles into radio-activatable therapeutics through synergistic ferroptosis for enhanced cancer radiotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transforming lipid nanoparticles into radio-activatable therapeutics through synergistic ferroptosis for enhanced cancer radiotherapy.
1100,2622,41532074,10.1002/smsc.202500506,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Triplet RNA Lipid Nanoparticles for Locoregional Cancer Immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Triplet RNA Lipid Nanoparticles for Locoregional Cancer Immunotherapy.
1106,2638,41500345,10.1016/j.ijpharm.2026.126567,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Vitamin A-spermine conjugated lipid nanoparticles for efficient nucleic acid delivery in ocular and hepatocellular cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Vitamin A-spermine conjugated lipid nanoparticles for efficient nucleic acid delivery in ocular and hepatocellular cells.
1107,2639,41500345,10.1016/j.ijpharm.2026.126567,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Vitamin A-spermine conjugated lipid nanoparticles for efficient nucleic acid delivery in ocular and hepatocellular cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Vitamin A-spermine conjugated lipid nanoparticles for efficient nucleic acid delivery in ocular and hepatocellular cells.
1110,2646,41437666,10.1002/anie.202524814,chemistry,ASO,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: A Photoelectrocatalytic Platform for Sequence-Unrestricted Modification of Oligonucleotide Backbones.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Photoelectrocatalytic Platform for Sequence-Unrestricted Modification of Oligonucleotide Backbones.
1111,2649,41424446,10.1021/acsnano.5c18243,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Leveraging Cisplatin-Derived Prodrugs as Helper Lipids in LNPs to Boost the Efficacy of Cancer Chemoimmunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Leveraging Cisplatin-Derived Prodrugs as Helper Lipids in LNPs to Boost the Efficacy of Cancer Chemoimmunotherapy.
1112,2652,41403214,10.1080/1061186X.2025.2581984,delivery,siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanotechnology-based PD-L1 siRNA codelivery systems for improving cancer immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanotechnology-based PD-L1 siRNA codelivery systems for improving cancer immunotherapy.
1114,2658,41365154,10.1016/j.jpba.2025.117298,delivery,ASO,PubMed abstract sentence 4,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: A universal LC-HRMS workflow integrating targeted and untargeted strategies for rapid and comprehensive metabolite profiling of oligonucleotide-based therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A universal LC-HRMS workflow integrating targeted and untargeted strategies for rapid and comprehensive metabolite profiling of oligonucleotide-based therapeutics.
1120,2672,41220296,10.1002/adhm.202503748,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Photosensitizing Lipid Nanoparticles for Ferroptosis-Enhanced Photodynamic Cancer Therapy via GPX4 Silencing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Photosensitizing Lipid Nanoparticles for Ferroptosis-Enhanced Photodynamic Cancer Therapy via GPX4 Silencing.
1125,2685,42004278,10.59566/isrnn.2025.0201e,delivery,siRNA,PubMed abstract sentence 9,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: CD133-Guided RNA Nanoparticle Delivery of FTO siRNA Impairs Leukemia Resistance to Tyrosine Kinase Inhibitor Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CD133-Guided RNA Nanoparticle Delivery of FTO siRNA Impairs Leukemia Resistance to Tyrosine Kinase Inhibitor Therapy.
1128,2690,41658564,10.3389/fonc.2025.1722906,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Direct pulmonary delivery route in lung cancer: a highway for siRNA therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Direct pulmonary delivery route in lung cancer: a highway for siRNA therapeutics.
1131,2697,41480638,10.1093/narcan/zcaf053,toxicity,ASO,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: IGF1R-targeted delivery of a bridged nucleic acid oligonucleotide-peptide conjugate for microRNA-21 inhibition in triple-negative breast cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,IGF1R-targeted delivery of a bridged nucleic acid oligonucleotide-peptide conjugate for microRNA-21 inhibition in triple-negative breast cancer.
1133,2703,41446212,10.64898/2025.12.17.693452,delivery,siRNA,PubMed abstract sentence 2,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid.
1134,2704,41446212,10.64898/2025.12.17.693452,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid.
1136,2708,41429785,10.1038/s41467-025-66765-x,chemistry,ASO,PubMed abstract sentence 2,phosphorothioate;2'-o,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o; source title: Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection."
1137,2711,41425586,10.3389/fimmu.2025.1718256,delivery,siRNA,PubMed abstract sentence 5,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Nanocarrier-based delivery of siRNA therapeutics in rheumatoid arthritis: immune mechanisms and translational perspectives.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanocarrier-based delivery of siRNA therapeutics in rheumatoid arthritis: immune mechanisms and translational perspectives.
1144,2732,41268339,10.1016/j.bioactmat.2025.09.007,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: A naturally derived lipopeptide lipid nanoparticle platform enabling multiple nucleic acids delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A naturally derived lipopeptide lipid nanoparticle platform enabling multiple nucleic acids delivery.
1145,2733,41268339,10.1016/j.bioactmat.2025.09.007,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: A naturally derived lipopeptide lipid nanoparticle platform enabling multiple nucleic acids delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A naturally derived lipopeptide lipid nanoparticle platform enabling multiple nucleic acids delivery.
1148,2744,41173907,10.1038/s41598-025-21877-8,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Immunomodulation of behavior impairment via spleen-specific targeting lipid nanoparticles in a MeCP2 transgenic mouse model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Immunomodulation of behavior impairment via spleen-specific targeting lipid nanoparticles in a MeCP2 transgenic mouse model.
1151,2749,41163544,10.1093/nar/gkaf1063,assay,siRNA,PubMed abstract sentence 6,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia.
1152,2752,41155969,10.3390/pharmaceutics17101334,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipid Nanoparticle-Mediated RNAi Against GIPC1 Overcomes Chemoresistance in Pancreatic Ductal Adenocarcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticle-Mediated RNAi Against GIPC1 Overcomes Chemoresistance in Pancreatic Ductal Adenocarcinoma.
1153,2755,41111990,10.30498/ijb.2025.486953.4018,delivery,ASO,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Exploring the Therapeutic Potential: Antisense RNA Delivery Via Bacteriophage Platform.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exploring the Therapeutic Potential: Antisense RNA Delivery Via Bacteriophage Platform.
1156,2760,41050095,10.1016/j.mtbio.2025.102314,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: pH-responsive 2D niobium carbide nanosheets for targeted circPUM1 siRNA delivery in ovarian cancer therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,pH-responsive 2D niobium carbide nanosheets for targeted circPUM1 siRNA delivery in ovarian cancer therapy.
1157,2765,41043736,10.1016/j.ijbiomac.2025.148058,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Incorporation of monophosphoryl lipid A and CpG-oligodeoxynucleotides into lipid nanoparticles activates toll-like receptor signaling pathways while maintaining antigen expression for mRNA-based vaccinations.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Incorporation of monophosphoryl lipid A and CpG-oligodeoxynucleotides into lipid nanoparticles activates toll-like receptor signaling pathways while maintaining antigen expression for mRNA-based vaccinations.
1158,2768,41038078,10.1016/j.chroma.2025.466395,assay,ASO,PubMed abstract sentence 5,screen;phase,"assay candidate; matched derived terms: screen, phase; source title: Systematic evaluation of phenyl stationary phases for oligonucleotide analysis without ion-pairing reagents.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Systematic evaluation of phenyl stationary phases for oligonucleotide analysis without ion-pairing reagents.
1159,2771,41027940,10.1038/s41467-025-63718-2,assay,siRNA,PubMed abstract sentence 10,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Engineered exosomes with Kras(G12D) specific siRNA in pancreatic cancer: a phase I study with immunological correlates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered exosomes with Kras(G12D) specific siRNA in pancreatic cancer: a phase I study with immunological correlates.
1165,2787,40960849,10.1021/acs.jmedchem.5c01893,delivery,ASO,PubMed abstract sentence 4,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Targeted Delivery of Oligonucleotide-Peptide Conjugates for Enhanced Kidney-Specific Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted Delivery of Oligonucleotide-Peptide Conjugates for Enhanced Kidney-Specific Therapy.
1167,2793,40901740,10.1080/17435889.2025.2555507,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Emerging lipid nanoparticle systems capable of efficient intramuscular RNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Emerging lipid nanoparticle systems capable of efficient intramuscular RNA delivery.
1168,2794,40901740,10.1080/17435889.2025.2555507,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Emerging lipid nanoparticle systems capable of efficient intramuscular RNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Emerging lipid nanoparticle systems capable of efficient intramuscular RNA delivery.
1172,2806,40832631,10.1016/j.omtn.2025.102645,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice.
1174,2810,40825982,10.1038/s41467-025-63037-6,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeting intestinal inflammation using locked nucleic acids delivered via lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting intestinal inflammation using locked nucleic acids delivered via lipid nanoparticles.
1175,2811,40825982,10.1038/s41467-025-63037-6,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting intestinal inflammation using locked nucleic acids delivered via lipid nanoparticles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting intestinal inflammation using locked nucleic acids delivered via lipid nanoparticles.
1176,2816,40772591,10.1021/acsnano.5c06115,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Synergizing Ferroptosis Suppressor Protein 1 Gene Silencing and Photodynamic Therapy Based on Photosensitive Lipid Nanoparticles for Colon Cancer Immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synergizing Ferroptosis Suppressor Protein 1 Gene Silencing and Photodynamic Therapy Based on Photosensitive Lipid Nanoparticles for Colon Cancer Immunotherapy.
1180,2824,40704024,10.1016/j.omtn.2025.102623,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Combined cancer immunotherapy with lipid nanoparticle delivery of oligo-based cGAS-agonistic adjuvant and peptide or mRNA vaccines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Combined cancer immunotherapy with lipid nanoparticle delivery of oligo-based cGAS-agonistic adjuvant and peptide or mRNA vaccines.
1182,2828,40703143,10.1007/s12170-025-00759-8,assay,ASO/siRNA,PubMed abstract sentence 10,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Current Clinical Trials for Treating Elevated Lipoprotein(a).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Current Clinical Trials for Treating Elevated Lipoprotein(a).
1184,2832,40701271,10.1016/j.jconrel.2025.114055,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Ionizable lipid chemistry in lipid nanoparticles determines delivery efficiency to hepatic stellate cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ionizable lipid chemistry in lipid nanoparticles determines delivery efficiency to hepatic stellate cells.
1185,2833,40701271,10.1016/j.jconrel.2025.114055,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ionizable lipid chemistry in lipid nanoparticles determines delivery efficiency to hepatic stellate cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ionizable lipid chemistry in lipid nanoparticles determines delivery efficiency to hepatic stellate cells.
1187,2837,40700483,10.1126/sciadv.adv6990,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineering hybrid nanoparticles for targeted codelivery of triptolide and CYP3A4-siRNA against pulmonary metastatic melanoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Engineering hybrid nanoparticles for targeted codelivery of triptolide and CYP3A4-siRNA against pulmonary metastatic melanoma.
1191,2847,40654340,10.1016/j.apsb.2025.04.003,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Self-degradable ""gemini-like"" ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Self-degradable ""gemini-like"" ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases."
1193,2853,40609116,10.1021/acs.bioconjchem.5c00205,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Multicheckpoint Cellular Targeting of siRNAs Using Antibody-Directed Lipid-Polymer Hybrid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multicheckpoint Cellular Targeting of siRNAs Using Antibody-Directed Lipid-Polymer Hybrid Nanoparticles.
1198,2868,40506605,10.1007/s10928-025-09980-9,delivery,ASO,PubMed abstract sentence 4,galnac;conjugated;uptake,"delivery candidate; matched derived terms: galnac, conjugated, uptake; source title: Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics.
1199,2869,40506605,10.1007/s10928-025-09980-9,assay,ASO,PubMed abstract sentence 5,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics.
1201,2875,40443118,10.1021/acs.bioconjchem.5c00156,chemistry,siRNA,PubMed abstract sentence 6,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Multimeric Conjugates Using Engineered Peptide Scaffolds for Efficient siRNA Delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multimeric Conjugates Using Engineered Peptide Scaffolds for Efficient siRNA Delivery.
1202,2876,40443118,10.1021/acs.bioconjchem.5c00156,delivery,siRNA,PubMed abstract sentence 6,delivery;galnac;conjugated,"delivery candidate; matched derived terms: delivery, galnac, conjugated; source title: Multimeric Conjugates Using Engineered Peptide Scaffolds for Efficient siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multimeric Conjugates Using Engineered Peptide Scaffolds for Efficient siRNA Delivery.
1206,2884,40438965,10.1080/20415990.2025.2506977,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: The role of excipients in lipid nanoparticle metabolism: implications for enhanced therapeutic effect.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The role of excipients in lipid nanoparticle metabolism: implications for enhanced therapeutic effect.
1207,2889,40418189,10.1089/nat.2024.0077,chemistry,siRNA,PubMed abstract sentence 1,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Systematic Evaluation of Position-Specific Tolerability of Seven Backbone and Ribose Modifications in Fully Chemically Stabilized siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Systematic Evaluation of Position-Specific Tolerability of Seven Backbone and Ribose Modifications in Fully Chemically Stabilized siRNAs.
1210,2894,40414500,10.1016/j.jconrel.2025.113850,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Amphiphilic dendrimer-assisted delivery of antisense nucleic acid mimics against E. coli.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Amphiphilic dendrimer-assisted delivery of antisense nucleic acid mimics against E. coli.
1211,2897,40354673,10.1021/acsabm.5c00489,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanotechnology-Enhanced siRNA Delivery: Revolutionizing Cancer Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanotechnology-Enhanced siRNA Delivery: Revolutionizing Cancer Therapy.
1216,2912,40187867,10.1016/j.aca.2025.343944,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Characterization of lipid nanoparticles using macro mass photometry: Insights into size and mass.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Characterization of lipid nanoparticles using macro mass photometry: Insights into size and mass.
1218,2916,40178922,10.34067/KID.0000000771,toxicity,ASO,PubMed abstract sentence 13,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Ameliorative Effect of an Anti-MicroRNA-21 Oligonucleotide on Animal and Human Models of Cystic Kidney Disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Ameliorative Effect of an Anti-MicroRNA-21 Oligonucleotide on Animal and Human Models of Cystic Kidney Disease.
1222,2922,40161818,10.1101/2025.03.09.642231,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: IGF1R-Targeted Delivery of a Bridged Nucleic Acid Oligonucleotide-Peptide Conjugate for MicroRNA-21 Inhibition in Triple-Negative Breast Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,IGF1R-Targeted Delivery of a Bridged Nucleic Acid Oligonucleotide-Peptide Conjugate for MicroRNA-21 Inhibition in Triple-Negative Breast Cancer.
1223,2927,40083288,10.1002/cpt.3641,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Model-Informed Drug Development Applications and Opportunities in mRNA-LNP Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Model-Informed Drug Development Applications and Opportunities in mRNA-LNP Therapeutics.
1225,2929,40083288,10.1002/cpt.3641,benchmark,ASO/siRNA,PubMed abstract sentence 3,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Model-Informed Drug Development Applications and Opportunities in mRNA-LNP Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Model-Informed Drug Development Applications and Opportunities in mRNA-LNP Therapeutics.
1226,2932,40052708,10.1021/acs.jmedchem.4c02275,chemistry,siRNA,PubMed abstract sentence 1,chemical;galnac;lna,"chemistry candidate; matched derived terms: chemical, galnac, lna; source title: Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo.
1227,2933,40052708,10.1021/acs.jmedchem.4c02275,delivery,siRNA,PubMed abstract sentence 5,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo.
1229,2939,40035231,10.1021/acs.molpharmaceut.4c01039,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid Nanoparticles and PEG: Time Frame of Immune Checkpoint Blockade Can Be Controlled by Adjusting the Rate of Cellular Uptake of Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticles and PEG: Time Frame of Immune Checkpoint Blockade Can Be Controlled by Adjusting the Rate of Cellular Uptake of Nanoparticles.
1231,2943,40034207,10.1016/j.omtn.2025.102468,chemistry,ASO,PubMed abstract sentence 3,phosphorothioate;lna,"chemistry candidate; matched derived terms: phosphorothioate, lna; source title: Effect of chemical modification on the exon-skipping activity of heteroduplex oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of chemical modification on the exon-skipping activity of heteroduplex oligonucleotides.
1235,2953,39987694,10.1016/j.chroma.2025.465788,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A platform method for simultaneous quantification of lipid and nucleic acid components in lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A platform method for simultaneous quantification of lipid and nucleic acid components in lipid nanoparticles.
1236,2958,39962990,10.1002/cmdc.202400938,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Advances in Lipid Nanoparticle-Based Disease Treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in Lipid Nanoparticle-Based Disease Treatment.
1239,2965,39948537,10.1186/s12885-025-13623-0,assay,ASO,PubMed abstract sentence 5,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Investigator-initiated phase I trial of an oligonucleotide therapeutic targeting long noncoding RNA TUG 1 for recurrent glioblastoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Investigator-initiated phase I trial of an oligonucleotide therapeutic targeting long noncoding RNA TUG 1 for recurrent glioblastoma.
1240,2968,39926316,10.1016/j.omtn.2024.102422,chemistry,ASO,PubMed abstract sentence 3,modification;2'-o;lna,"chemistry candidate; matched derived terms: modification, 2'-o, lna; source title: Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform.
1244,2984,39654352,10.1002/jcph.6174,assay,siRNA,PubMed abstract sentence 2,preclinical;phase,"assay candidate; matched derived terms: preclinical, phase; source title: Preclinical and Clinical Pharmacokinetics of JNJ-75220795, an siRNA Therapeutic Targeting PNPLA3, for Metabolic Dysfunction-Associated Steatohepatitis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Preclinical and Clinical Pharmacokinetics of JNJ-75220795, an siRNA Therapeutic Targeting PNPLA3, for Metabolic Dysfunction-Associated Steatohepatitis."
1245,2989,39631700,10.1016/j.jconrel.2024.11.073,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Corosolic acid derivative-based lipid nanoparticles for efficient RNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Corosolic acid derivative-based lipid nanoparticles for efficient RNA delivery.
1247,2993,39385468,10.1016/j.ymthe.2024.10.003,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Efficient and safe in vivo treatment of primary hyperoxaluria type 1 via LNP-CRISPR-Cas9-mediated glycolate oxidase disruption.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient and safe in vivo treatment of primary hyperoxaluria type 1 via LNP-CRISPR-Cas9-mediated glycolate oxidase disruption.
1249,2997,39771501,10.3390/pharmaceutics16121521,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System.
1251,3001,39633726,10.1093/nargab/lqae155,chemistry,ASO,PubMed abstract sentence 2,phosphorothioate;2'-o;2'-moe;lna,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o, 2'-moe, lna; source title: Comparative molecular dynamics calculations of duplexation of chemically modified analogs of DNA used for antisense applications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comparative molecular dynamics calculations of duplexation of chemically modified analogs of DNA used for antisense applications.
1252,3004,39589900,10.1021/acs.jmedchem.4c02239,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Probing Different Lengths of the Tertiary Amine Head Group on Triglyceride-Mimetic Ionizable Lipid-Mediated siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Probing Different Lengths of the Tertiary Amine Head Group on Triglyceride-Mimetic Ionizable Lipid-Mediated siRNA Delivery.
1256,3012,39543630,10.1186/s12951-024-02972-w,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach.
1257,3013,39543630,10.1186/s12951-024-02972-w,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach.
1258,3016,39525592,10.1016/j.apsb.2024.06.011,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approaches.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approaches.
1263,3025,39447842,10.1016/j.jconrel.2024.10.047,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Optimizing lipid nanoparticles for fetal gene delivery in vitro, ex vivo, and aided with machine learning.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Optimizing lipid nanoparticles for fetal gene delivery in vitro, ex vivo, and aided with machine learning."
1264,3026,39447842,10.1016/j.jconrel.2024.10.047,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Optimizing lipid nanoparticles for fetal gene delivery in vitro, ex vivo, and aided with machine learning.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Optimizing lipid nanoparticles for fetal gene delivery in vitro, ex vivo, and aided with machine learning."
1266,3030,39442238,10.1016/j.biopha.2024.117587,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Therapeutic oligonucleotide ASC1R shows excellent tolerability and remarkable efficacy in reducing SARS-CoV-2 mRNA levels in C57BL/6 mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Therapeutic oligonucleotide ASC1R shows excellent tolerability and remarkable efficacy in reducing SARS-CoV-2 mRNA levels in C57BL/6 mice.
1267,3033,39437973,10.1016/j.bbagen.2024.130727,chemistry,siRNA,PubMed abstract sentence 3,phosphorothioate;2'-o,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o; source title: Effect of modification of siRNA molecules delivered with aminopropylsilanol nanoparticles on suppression of A/H5N1 virus in cell culture.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of modification of siRNA molecules delivered with aminopropylsilanol nanoparticles on suppression of A/H5N1 virus in cell culture.
1270,3038,39363106,10.1038/s41551-024-01256-w,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d.
1275,3049,39309631,10.1016/j.ijpx.2024.100283,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Comprehensive analysis of lipid nanoparticle formulation and preparation for RNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comprehensive analysis of lipid nanoparticle formulation and preparation for RNA delivery.
1276,3050,39309631,10.1016/j.ijpx.2024.100283,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Comprehensive analysis of lipid nanoparticle formulation and preparation for RNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comprehensive analysis of lipid nanoparticle formulation and preparation for RNA delivery.
1277,3055,39264964,10.1371/journal.pntd.0012502,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Development of a Lipid-encapsulated TGFβRI-siRNA Drug for Liver Fibrosis Induced by Schistosoma mansoni.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of a Lipid-encapsulated TGFβRI-siRNA Drug for Liver Fibrosis Induced by Schistosoma mansoni.
1278,3056,39264964,10.1371/journal.pntd.0012502,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of a Lipid-encapsulated TGFβRI-siRNA Drug for Liver Fibrosis Induced by Schistosoma mansoni.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of a Lipid-encapsulated TGFβRI-siRNA Drug for Liver Fibrosis Induced by Schistosoma mansoni.
1279,3059,39233550,10.1002/adma.202401445,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Tuning Lipid Nanoparticles for RNA Delivery to Extrahepatic Organs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tuning Lipid Nanoparticles for RNA Delivery to Extrahepatic Organs.
1281,3063,39212195,10.1002/adhm.202402259,delivery,ASO/siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A Multifunctional Aptamer Decorated Lipid Nanoparticles for the Delivery of EpCAM-targeted CRISPR/Cas9 Plasmid for Efficacious In Vivo Tumor Regression.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Multifunctional Aptamer Decorated Lipid Nanoparticles for the Delivery of EpCAM-targeted CRISPR/Cas9 Plasmid for Efficacious In Vivo Tumor Regression.
1283,3067,39179112,10.1016/j.jconrel.2024.08.030,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Enhancing RNA-lipid nanoparticle delivery: Organ- and cell-specificity and barcoding strategies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhancing RNA-lipid nanoparticle delivery: Organ- and cell-specificity and barcoding strategies.
1286,3076,39154935,10.1016/j.jconrel.2024.08.012,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Engineered lipid nanoparticles enable therapeutic gene silencing of GTSE1 for the treatment of liver fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered lipid nanoparticles enable therapeutic gene silencing of GTSE1 for the treatment of liver fibrosis.
1287,3077,39154935,10.1016/j.jconrel.2024.08.012,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineered lipid nanoparticles enable therapeutic gene silencing of GTSE1 for the treatment of liver fibrosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineered lipid nanoparticles enable therapeutic gene silencing of GTSE1 for the treatment of liver fibrosis.
1293,3093,38932395,10.3390/vaccines12060666,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid Nanoparticles Outperform Electroporation in Delivering Therapeutic HPV DNA Vaccines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticles Outperform Electroporation in Delivering Therapeutic HPV DNA Vaccines.
1295,3099,38829703,10.2215/CJN.0000000000000458,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: A Randomized Controlled Clinical Trial Testing Effects of Lademirsen on Kidney Function Decline in Adults with Alport Syndrome.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Randomized Controlled Clinical Trial Testing Effects of Lademirsen on Kidney Function Decline in Adults with Alport Syndrome.
1296,3100,38829703,10.2215/CJN.0000000000000458,toxicity,ASO/siRNA,PubMed abstract sentence 14,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: A Randomized Controlled Clinical Trial Testing Effects of Lademirsen on Kidney Function Decline in Adults with Alport Syndrome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Randomized Controlled Clinical Trial Testing Effects of Lademirsen on Kidney Function Decline in Adults with Alport Syndrome.
1297,3103,38829038,10.1002/smll.202402362,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Imidazolyl Lipids Enhanced LNP Endosomal Escape for Ferroptosis RNAi Treatment of Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Imidazolyl Lipids Enhanced LNP Endosomal Escape for Ferroptosis RNAi Treatment of Cancer.
1298,3108,38814398,10.1007/978-1-0716-3770-8_11,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: A Basic Method for Formulating mRNA-Lipid Nanoparticle Vaccines in the Lab.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Basic Method for Formulating mRNA-Lipid Nanoparticle Vaccines in the Lab.
1299,3119,38675231,10.3390/pharmaceutics16040570,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Combination of miR159 Mimics and Irinotecan Utilizing Lipid Nanoparticles for Enhanced Treatment of Colorectal Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Combination of miR159 Mimics and Irinotecan Utilizing Lipid Nanoparticles for Enhanced Treatment of Colorectal Cancer.
1300,3122,38538323,10.1248/bpb.b23-00689,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lymphatic Endothelial Cells Produce Chemokines in Response to the Lipid Nanoparticles Used in RNA Vaccines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lymphatic Endothelial Cells Produce Chemokines in Response to the Lipid Nanoparticles Used in RNA Vaccines.
1301,3125,38514237,10.1021/acsnano.4c02610,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Mesoscopic Structure of Lipid Nanoparticle Formulations for mRNA Drug Delivery: Comirnaty and Drug-Free Dispersions.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mesoscopic Structure of Lipid Nanoparticle Formulations for mRNA Drug Delivery: Comirnaty and Drug-Free Dispersions.
1304,3132,38493950,10.1016/j.jconrel.2024.03.018,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Plasmid DNA ionisable lipid nanoparticles as non-inert carriers and potent immune activators for cancer immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Plasmid DNA ionisable lipid nanoparticles as non-inert carriers and potent immune activators for cancer immunotherapy.
1307,3139,38435821,10.1002/btm2.10601,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A landscape of recent advances in lipid nanoparticles and their translational potential for the treatment of solid tumors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A landscape of recent advances in lipid nanoparticles and their translational potential for the treatment of solid tumors.
1310,3144,38377276,10.1002/smll.202311690,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cholesterol-Modified DNA Nanostructures Serve as Effective Non-Viral Carriers for Delivering siRNA to the Kidneys to Prevent Acute Kidney Injury.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cholesterol-Modified DNA Nanostructures Serve as Effective Non-Viral Carriers for Delivering siRNA to the Kidneys to Prevent Acute Kidney Injury.
1311,3147,38346479,10.1016/j.ejpb.2024.114213,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles.
1312,3150,38341177,10.1016/j.jconrel.2024.02.007,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma.
1313,3151,38341177,10.1016/j.jconrel.2024.02.007,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma.
1314,3154,38291016,10.1080/13543784.2024.2313105,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Duchenne muscular dystrophy: promising early-stage clinical trials to watch.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Duchenne muscular dystrophy: promising early-stage clinical trials to watch.
1317,3161,38253203,10.1016/j.jconrel.2024.01.037,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques.
1318,3164,38218350,10.1016/j.addr.2023.115175,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: The immunostimulatory nature of mRNA lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The immunostimulatory nature of mRNA lipid nanoparticles.
1319,3167,38189247,10.1021/acs.analchem.3c04406,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Quantification of mRNA in Lipid Nanoparticles Using Mass Spectrometry.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Quantification of mRNA in Lipid Nanoparticles Using Mass Spectrometry.
1320,3170,38148611,10.1021/jacs.3c12706,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nuclear-Targeting Lipid Pt(IV) Prodrug Amphiphile Cooperates with siRNA for Enhanced Cancer Immunochemotherapy by Amplifying Pt-DNA Adducts and Reducing Phosphatidylserine Exposure.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nuclear-Targeting Lipid Pt(IV) Prodrug Amphiphile Cooperates with siRNA for Enhanced Cancer Immunochemotherapy by Amplifying Pt-DNA Adducts and Reducing Phosphatidylserine Exposure.
1321,3173,38145661,10.1016/j.jconrel.2023.12.035,chemistry,ASO,PubMed abstract sentence 2,chemical;modified;conjugate,"chemistry candidate; matched derived terms: chemical, modified, conjugate; source title: Enabling safer, more potent oligonucleotide therapeutics with bottlebrush polymer conjugates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Enabling safer, more potent oligonucleotide therapeutics with bottlebrush polymer conjugates."
1322,3174,38145661,10.1016/j.jconrel.2023.12.035,delivery,ASO,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Enabling safer, more potent oligonucleotide therapeutics with bottlebrush polymer conjugates.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Enabling safer, more potent oligonucleotide therapeutics with bottlebrush polymer conjugates."
1323,3177,38118363,10.1016/j.copbio.2023.103049,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Immune response to the components of lipid nanoparticles for ribonucleic acid therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Immune response to the components of lipid nanoparticles for ribonucleic acid therapeutics.
1324,3178,38118363,10.1016/j.copbio.2023.103049,toxicity,ASO/siRNA,PubMed abstract sentence 1,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Immune response to the components of lipid nanoparticles for ribonucleic acid therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Immune response to the components of lipid nanoparticles for ribonucleic acid therapeutics.
1325,3181,38018280,10.1002/adma.202309225,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Nanoparticle-Mediated Delivery of Anti-PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticle-Mediated Delivery of Anti-PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation.
1326,3182,38018280,10.1002/adma.202309225,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoparticle-Mediated Delivery of Anti-PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanoparticle-Mediated Delivery of Anti-PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation.
1328,3186,37994483,10.1002/adhm.202302712,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Poly(N-methyl-N-vinylacetamide): A Strong Alternative to PEG for Lipid-Based Nanocarriers Delivering siRNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Poly(N-methyl-N-vinylacetamide): A Strong Alternative to PEG for Lipid-Based Nanocarriers Delivering siRNA.
1329,3189,37579889,10.1016/j.ejpb.2023.08.002,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Evaluating how cationic lipid affects mRNA-LNP physical properties and biodistribution.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluating how cationic lipid affects mRNA-LNP physical properties and biodistribution.
1332,3196,38079547,10.1073/pnas.2311276120,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Biomimetic noncationic lipid nanoparticles for mRNA delivery.",C,high_candidate,curator_rejected,reject,derived_annotations_only,Biomimetic noncationic lipid nanoparticles for mRNA delivery.
1333,3197,38079547,10.1073/pnas.2311276120,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: Biomimetic noncationic lipid nanoparticles for mRNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Biomimetic noncationic lipid nanoparticles for mRNA delivery.
1334,3200,38055742,10.1073/pnas.2310491120,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function.
1336,3204,37919256,10.1021/acs.molpharmaceut.3c00555,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Multiphysics-Informed Pharmacokinetic Modeling of Systemic Exposure of Intramuscularly Injected LNPs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multiphysics-Informed Pharmacokinetic Modeling of Systemic Exposure of Intramuscularly Injected LNPs.
1337,3205,37919256,10.1021/acs.molpharmaceut.3c00555,assay,ASO/siRNA,PubMed abstract sentence 6,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Multiphysics-Informed Pharmacokinetic Modeling of Systemic Exposure of Intramuscularly Injected LNPs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multiphysics-Informed Pharmacokinetic Modeling of Systemic Exposure of Intramuscularly Injected LNPs.
1339,3211,37871289,10.1021/acs.biomac.3c00813,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bioresponsive Chimaeric Polymersomes Mediate Sustained and Liver-Specific siRNA Transfection In Vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Bioresponsive Chimaeric Polymersomes Mediate Sustained and Liver-Specific siRNA Transfection In Vivo.
1340,3214,37798336,10.1038/s41598-023-43898-x,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Elucidation of lipid nanoparticle surface structure in mRNA vaccines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Elucidation of lipid nanoparticle surface structure in mRNA vaccines.
1341,3219,37772637,10.1002/adhm.202301687,delivery,ASO/siRNA,PubMed abstract sentence 6,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue.
1342,3220,37772637,10.1002/adhm.202301687,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue.
1343,3223,37741463,10.1016/j.jconrel.2023.09.031,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Spray dried lipid nanoparticle formulations enable intratracheal delivery of mRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Spray dried lipid nanoparticle formulations enable intratracheal delivery of mRNA.
1345,3227,37729550,10.1021/acs.biochem.3c00371,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection.
1346,3228,37729550,10.1021/acs.biochem.3c00371,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection.
1347,3231,37602495,10.1002/adhm.202301515,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering.
1349,3237,37538053,10.1016/j.omtn.2023.06.022,delivery,ASO,PubMed abstract sentence 9,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders.
1350,3238,37538053,10.1016/j.omtn.2023.06.022,assay,ASO,PubMed abstract sentence 6,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders.
1351,3239,37538053,10.1016/j.omtn.2023.06.022,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The endosomal escape vehicle platform enhances delivery of oligonucleotides in preclinical models of neuromuscular disorders.
1355,3253,37251983,10.1016/j.omtm.2023.05.008,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Studying how administration route and dose regulates antibody generation against LNPs for mRNA delivery with single-particle resolution.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Studying how administration route and dose regulates antibody generation against LNPs for mRNA delivery with single-particle resolution.
1358,3258,37241787,10.3390/molecules28104046,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Ionizable Lipids with Triazole Moiety from Click Reaction for LNP-Based mRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ionizable Lipids with Triazole Moiety from Click Reaction for LNP-Based mRNA Delivery.
1360,3262,37208184,10.1124/dmd.122.000980,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Biodistribution of Lipid 5, mRNA, and Its Translated Protein Following Intravenous Administration of mRNA-Encapsulated Lipid Nanoparticles in Rats.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Biodistribution of Lipid 5, mRNA, and Its Translated Protein Following Intravenous Administration of mRNA-Encapsulated Lipid Nanoparticles in Rats."
1361,3265,37201764,10.1016/j.ijpharm.2023.123050,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Optimization of formulation and atomization of lipid nanoparticles for the inhalation of mRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimization of formulation and atomization of lipid nanoparticles for the inhalation of mRNA.
1362,3268,37111616,10.3390/pharmaceutics15041130,chemistry,ASO,PubMed abstract sentence 4,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Enhancing the Effectiveness of Oligonucleotide Therapeutics Using Cell-Penetrating Peptide Conjugation, Chemical Modification, and Carrier-Based Delivery Strategies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Enhancing the Effectiveness of Oligonucleotide Therapeutics Using Cell-Penetrating Peptide Conjugation, Chemical Modification, and Carrier-Based Delivery Strategies."
1363,3269,37111616,10.3390/pharmaceutics15041130,delivery,ASO,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Enhancing the Effectiveness of Oligonucleotide Therapeutics Using Cell-Penetrating Peptide Conjugation, Chemical Modification, and Carrier-Based Delivery Strategies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Enhancing the Effectiveness of Oligonucleotide Therapeutics Using Cell-Penetrating Peptide Conjugation, Chemical Modification, and Carrier-Based Delivery Strategies."
1364,3270,37111616,10.3390/pharmaceutics15041130,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Enhancing the Effectiveness of Oligonucleotide Therapeutics Using Cell-Penetrating Peptide Conjugation, Chemical Modification, and Carrier-Based Delivery Strategies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Enhancing the Effectiveness of Oligonucleotide Therapeutics Using Cell-Penetrating Peptide Conjugation, Chemical Modification, and Carrier-Based Delivery Strategies."
1365,3275,36988645,10.1021/acs.nanolett.3c00304,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles.
1366,3276,36988645,10.1021/acs.nanolett.3c00304,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles.
1367,3281,36839919,10.3390/pharmaceutics15020597,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Effect of PEG Anchor and Serum on Lipid Nanoparticles: Development of a Nanoparticles Tracking Method.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of PEG Anchor and Serum on Lipid Nanoparticles: Development of a Nanoparticles Tracking Method.
1368,3286,36773957,10.1016/j.jconrel.2023.02.008,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticle-based ribonucleoprotein delivery for in vivo genome editing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle-based ribonucleoprotein delivery for in vivo genome editing.
1369,3287,36773957,10.1016/j.jconrel.2023.02.008,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid nanoparticle-based ribonucleoprotein delivery for in vivo genome editing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid nanoparticle-based ribonucleoprotein delivery for in vivo genome editing.
1370,3290,36735581,10.1089/nat.2022.0046,chemistry,ASO,PubMed abstract sentence 4,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Chemical Modifications and Design Influence the Potency of Huntingtin Anti-Gene Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical Modifications and Design Influence the Potency of Huntingtin Anti-Gene Oligonucleotides.
1372,3298,36632217,10.7150/thno.73568,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic;risk;renal,"toxicity candidate; matched derived terms: toxicity, toxic, risk, renal; source title: Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia/reperfusion injury in mice and swine.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia/reperfusion injury in mice and swine.
1374,3304,36414195,10.1016/j.jconrel.2022.11.022,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Optimization of storage conditions for lipid nanoparticle-formulated self-replicating RNA vaccines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimization of storage conditions for lipid nanoparticle-formulated self-replicating RNA vaccines.
1375,3307,36325948,10.1002/adhm.202202127,chemistry,ASO/siRNA,PubMed abstract sentence 2,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Lipid Nanoparticle Delivery of Chemically Modified NGF(R100W) mRNA Alleviates Peripheral Neuropathy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticle Delivery of Chemically Modified NGF(R100W) mRNA Alleviates Peripheral Neuropathy.
1376,3308,36325948,10.1002/adhm.202202127,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid Nanoparticle Delivery of Chemically Modified NGF(R100W) mRNA Alleviates Peripheral Neuropathy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticle Delivery of Chemically Modified NGF(R100W) mRNA Alleviates Peripheral Neuropathy.
1378,3312,36520934,10.1371/journal.pone.0276905,delivery,siRNA,PubMed abstract sentence 6,nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: nanoparticle, lnp, uptake; source title: Inhibition of c-Rel expression in myeloid and lymphoid cells with distearoyl -phosphatidylserine (DSPS) liposomal nanoparticles encapsulating therapeutic siRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhibition of c-Rel expression in myeloid and lymphoid cells with distearoyl -phosphatidylserine (DSPS) liposomal nanoparticles encapsulating therapeutic siRNA.
1385,3331,36002054,10.1016/j.jconrel.2022.08.033,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid nanoparticles produce chimeric antigen receptor T cells with interleukin-6 knockdown in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles produce chimeric antigen receptor T cells with interleukin-6 knockdown in vivo.
1386,3334,35963467,10.1016/j.jconrel.2022.08.009,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs.
1391,3345,35787388,10.1016/j.addr.2022.114416,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;lnp;uptake,"delivery candidate; matched derived terms: delivery, lnp, uptake; source title: The role of lipid components in lipid nanoparticles for vaccines and gene therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The role of lipid components in lipid nanoparticles for vaccines and gene therapy.
1392,3348,35780952,10.1016/j.jconrel.2022.06.051,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;lnp,"delivery candidate; matched derived terms: delivery, lnp; source title: Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy.
1393,3351,35731922,10.1021/acs.molpharmaceut.2c00244,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Multifunctional Lipid Nanoparticles for Protein Kinase N3 shRNA Delivery and Prostate Cancer Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multifunctional Lipid Nanoparticles for Protein Kinase N3 shRNA Delivery and Prostate Cancer Therapy.
1394,3352,35731922,10.1021/acs.molpharmaceut.2c00244,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Multifunctional Lipid Nanoparticles for Protein Kinase N3 shRNA Delivery and Prostate Cancer Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Multifunctional Lipid Nanoparticles for Protein Kinase N3 shRNA Delivery and Prostate Cancer Therapy.
1396,3358,35671982,10.1016/j.virs.2022.06.002,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: LNP-CpG ODN-adjuvanted varicella-zoster virus glycoprotein E induced comparable levels of immunity with Shingrix™ in VZV-primed mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,LNP-CpG ODN-adjuvanted varicella-zoster virus glycoprotein E induced comparable levels of immunity with Shingrix™ in VZV-primed mice.
1397,3361,35642083,10.1021/acs.molpharmaceut.2c00033,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells.
1398,3362,35642083,10.1021/acs.molpharmaceut.2c00033,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells.
1403,3375,35024714,10.1039/d1nr06858j,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Development of a high-throughput platform for screening lipid nanoparticles for mRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of a high-throughput platform for screening lipid nanoparticles for mRNA delivery.
1407,3381,34850635,10.1021/acs.accounts.1c00544,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Chemistry of Lipid Nanoparticles for RNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemistry of Lipid Nanoparticles for RNA Delivery.
1409,3389,34873640,10.1208/s12248-021-00653-2,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells.
1410,3390,34873640,10.1208/s12248-021-00653-2,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells.
1411,3393,34853281,10.1248/cpb.c21-00705,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Development of Lipid Nanoparticles for the Delivery of Macromolecules Based on the Molecular Design of pH-Sensitive Cationic Lipids.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of Lipid Nanoparticles for the Delivery of Macromolecules Based on the Molecular Design of pH-Sensitive Cationic Lipids.
1413,3399,34668716,10.1021/acs.accounts.1c00500,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing.
1418,3410,34181394,10.1021/acsnano.1c04996,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement."
1420,3414,34140675,10.1038/s41565-021-00928-x,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics.
1421,3417,34101472,10.1021/acs.langmuir.1c00530,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Scalable Production of Lipid Nanoparticles Containing Amphotericin B.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Scalable Production of Lipid Nanoparticles Containing Amphotericin B.
1423,3423,33981364,10.3762/bjoc.17.75,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides.
1425,3429,33924589,10.3390/pharmaceutics13040544,delivery,ASO,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material.
1426,3430,33924589,10.3390/pharmaceutics13040544,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material.
1427,3433,33868782,10.1016/j.omtn.2021.03.008,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein.
1428,3436,33821570,10.15252/emmm.202013243,delivery,ASO,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Delivery of oligonucleotide-based therapeutics: challenges and opportunities.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of oligonucleotide-based therapeutics: challenges and opportunities.
1430,3440,33753212,10.1016/j.ejpb.2021.03.006,delivery,ASO,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Pronounced therapeutic potential of oligonucleotides fixed on inorganic nanoparticles against highly pathogenic H5N1 influenza A virus in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pronounced therapeutic potential of oligonucleotides fixed on inorganic nanoparticles against highly pathogenic H5N1 influenza A virus in vivo.
1433,3447,33477663,10.3390/pharmaceutics13010116,delivery,ASO,PubMed abstract sentence 11,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides.
1434,3448,33477663,10.3390/pharmaceutics13010116,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides.
1447,3491,41964558,10.1021/acs.analchem.5c08138,benchmark,ASO/siRNA,PubMed abstract sentence 7,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Clustered Regularly Interspaced Short Palindromic Repeat-Based Colorimetric Aptasensor Combined with Smartphone Imaging and Deep Learning Enables Selective Recycling and Visual Prediction of Microplastics in the Environment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clustered Regularly Interspaced Short Palindromic Repeat-Based Colorimetric Aptasensor Combined with Smartphone Imaging and Deep Learning Enables Selective Recycling and Visual Prediction of Microplastics in the Environment.
1450,3498,41774333,10.1007/s10620-026-09787-9,assay,ASO/siRNA,PubMed abstract sentence 5,screen;model,"assay candidate; matched derived terms: screen, model; source title: Regulatory Role of Ribosome Biogenesis-Related Genes in Hepatocellular Carcinoma Prognosis and Construction of a Risk Prediction Model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Regulatory Role of Ribosome Biogenesis-Related Genes in Hepatocellular Carcinoma Prognosis and Construction of a Risk Prediction Model.
1452,3500,41774333,10.1007/s10620-026-09787-9,benchmark,ASO/siRNA,PubMed abstract sentence 2,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Regulatory Role of Ribosome Biogenesis-Related Genes in Hepatocellular Carcinoma Prognosis and Construction of a Risk Prediction Model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Regulatory Role of Ribosome Biogenesis-Related Genes in Hepatocellular Carcinoma Prognosis and Construction of a Risk Prediction Model.
1453,3503,41709935,10.33160/yam.2026.02.001,benchmark,ASO/siRNA,PubMed abstract sentence 2,prediction;challenge,"benchmark candidate; matched derived terms: prediction, challenge; source title: Next-Generation Artificial Intelligence for ADME Prediction in Drug Discovery: From Small Molecules to Biologics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Next-Generation Artificial Intelligence for ADME Prediction in Drug Discovery: From Small Molecules to Biologics.
1454,3506,41453135,10.1093/eurjpc/zwaf783,assay,ASO/siRNA,PubMed abstract sentence 15,model;phase;trial,"assay candidate; matched derived terms: model, phase, trial; source title: Prediction of inclisiran efficacy in patients with established atherosclerotic cardiovascular disease: the SIRIUS In-Silico modelling of cardiovascular outcomes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prediction of inclisiran efficacy in patients with established atherosclerotic cardiovascular disease: the SIRIUS In-Silico modelling of cardiovascular outcomes.
1455,3507,41453135,10.1093/eurjpc/zwaf783,benchmark,ASO/siRNA,PubMed abstract sentence 15,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Prediction of inclisiran efficacy in patients with established atherosclerotic cardiovascular disease: the SIRIUS In-Silico modelling of cardiovascular outcomes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prediction of inclisiran efficacy in patients with established atherosclerotic cardiovascular disease: the SIRIUS In-Silico modelling of cardiovascular outcomes.
1457,3513,40348375,10.3168/jds.2024-25991,benchmark,ASO/siRNA,PubMed abstract sentence 6,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Development of prediction equations for immunoglobulin A, immunoglobulin G, and immunoglobulin M concentrations in mature milk from Holstein cows using milk infrared spectral data.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Development of prediction equations for immunoglobulin A, immunoglobulin G, and immunoglobulin M concentrations in mature milk from Holstein cows using milk infrared spectral data."
1470,3584,42213794,10.1021/acsbiomaterials.6c00085,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Polymeric Gene Delivery Systems: Design Principles for Targeting Oncogenic Pathways.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Polymeric Gene Delivery Systems: Design Principles for Targeting Oncogenic Pathways.
1472,3594,29459660,10.1038/s41467-018-02989-4,chemistry,siRNA,PubMed abstract sentence 6,chemical;modification;galnac;lna,"chemistry candidate; matched derived terms: chemical, modification, galnac, lna; source title: Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.
1473,3595,29459660,10.1038/s41467-018-02989-4,delivery,siRNA,PubMed abstract sentence 1,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.
1474,3596,29459660,10.1038/s41467-018-02989-4,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.
1475,3597,29459660,10.1038/s41467-018-02989-4,offtarget,siRNA,PubMed abstract sentence 4,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.
1476,3600,30583097,10.1016/j.omtn.2018.11.005,chemistry,ASO,PubMed abstract sentence 3,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.
1477,3601,30583097,10.1016/j.omtn.2018.11.005,delivery,ASO,PubMed abstract sentence 3,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.
1478,3602,30583097,10.1016/j.omtn.2018.11.005,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.
1479,3605,29390093,10.1093/nar/gky060,chemistry,ASO,PubMed abstract sentence 1,modified;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: modified, phosphorothioate, 2'-o; source title: Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.
1480,3606,29390093,10.1093/nar/gky060,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.
1481,3609,27461380,10.1038/srep30377,chemistry,ASO,PubMed abstract sentence 2,modified;lna,"chemistry candidate; matched derived terms: modified, lna; source title: Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides.
1482,3610,27461380,10.1038/srep30377,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides.
1483,3613,26553810,10.1093/nar/gkv1210,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
1484,3616,24550163,10.1093/nar/gku142,chemistry,ASO,PubMed abstract sentence 1,phosphorothioate;lna,"chemistry candidate; matched derived terms: phosphorothioate, lna; source title: Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides.
1485,3617,24550163,10.1093/nar/gku142,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;risk;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, risk, hepatotoxicity; source title: Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides.
1487,3621,28918038,10.1016/j.omtn.2017.07.003,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.
1492,3630,20886212,10.1007/s00280-010-1473-z,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Preclinical toxicity and toxicokinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase R2.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Preclinical toxicity and toxicokinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase R2."
1494,3634,41416527,10.1080/15376516.2025.2604731,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Role of connexin32 in zinc oxide nanoparticles induced hepatotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Role of connexin32 in zinc oxide nanoparticles induced hepatotoxicity.
1496,3640,41081640,10.1021/acs.chemrestox.5c00235,assay,ASO/siRNA,PubMed abstract sentence 4,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Industry Perspective on Nonclinical Approaches for Hepatotoxicity Risk Assessment: Insights from Two Longitudinal Surveys Conducted in 2023 and 2017.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Industry Perspective on Nonclinical Approaches for Hepatotoxicity Risk Assessment: Insights from Two Longitudinal Surveys Conducted in 2023 and 2017.
1499,3645,40990894,10.1002/jbt.70484,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;adverse;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, adverse, hepatotoxicity; source title: Ferroptosis and Lipid Peroxidation Participate in Valproic Acid-Induced Hepatotoxicity via the Long-chain Acyl-CoA Synthetase 4/Glutathione Peroxidase 4 Pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Ferroptosis and Lipid Peroxidation Participate in Valproic Acid-Induced Hepatotoxicity via the Long-chain Acyl-CoA Synthetase 4/Glutathione Peroxidase 4 Pathway.
1501,3651,40930455,10.1016/j.tox.2025.154277,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic;dna damage,"toxicity candidate; matched derived terms: toxicity, toxic, dna damage; source title: Differential effects of mercury compounds on mutagenicity, genotoxicity and repair of UV-DNA damage.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Differential effects of mercury compounds on mutagenicity, genotoxicity and repair of UV-DNA damage."
1502,3654,40288593,10.1016/j.phrs.2025.107738,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;adverse;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, adverse, hepatotoxicity; source title: FXR as a pivotal role linking JNK and G0s2 mitigates triptolide-induced hepatotoxicity through the regulation of metabolic disorder of liver.",B,high_candidate,curator_rejected,reject,derived_annotations_only,FXR as a pivotal role linking JNK and G0s2 mitigates triptolide-induced hepatotoxicity through the regulation of metabolic disorder of liver.
1503,3657,40157625,10.1016/j.cbi.2025.111491,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Inhibition of bromodomain and extra-terminal (BET) proteins with JQ1 exacerbates acetaminophen-induced hepatotoxicity by altering detoxification pathways and oxidative stress responses.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of bromodomain and extra-terminal (BET) proteins with JQ1 exacerbates acetaminophen-induced hepatotoxicity by altering detoxification pathways and oxidative stress responses.
1508,3668,39417036,10.1093/toxres/tfae173,toxicity,ASO/siRNA,PubMed abstract sentence 9,risk;adverse;renal,"toxicity candidate; matched derived terms: risk, adverse, renal; source title: 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) exposure induces hepatotoxicity and nephrotoxicity - role of oxidative stress, mitochondrial dysfunction and pathways of cytotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) exposure induces hepatotoxicity and nephrotoxicity - role of oxidative stress, mitochondrial dysfunction and pathways of cytotoxicity."
1510,3672,38822557,10.1177/10915818241255885,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;safety;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, safety, adverse; source title: Exploring Greater Flexibility for Chronic Toxicity Study Designs to Support Human Safety Assessment While Balancing 3Rs Considerations.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exploring Greater Flexibility for Chronic Toxicity Study Designs to Support Human Safety Assessment While Balancing 3Rs Considerations.
1511,3675,38181604,10.1016/j.ecoenv.2023.115911,toxicity,ASO/siRNA,PubMed abstract sentence 12,toxicity;toxic;risk;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, risk, hepatotoxicity; source title: Iprodione induces hepatotoxicity in zebrafish by mediating ROS generation and upregulating p53 signalling pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Iprodione induces hepatotoxicity in zebrafish by mediating ROS generation and upregulating p53 signalling pathway.
1512,3678,36820075,10.1016/j.jpha.2022.11.005,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway.
1514,3684,29708844,10.1089/nat.2017.0706,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chronic Toxicity Assessment of 2'-O-Methoxyethyl Antisense Oligonucleotides in Mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chronic Toxicity Assessment of 2'-O-Methoxyethyl Antisense Oligonucleotides in Mice.
1515,3687,28986168,10.1016/j.jconrel.2017.09.044,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus.
1516,3688,28986168,10.1016/j.jconrel.2017.09.044,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus.
1517,3691,24336348,10.1093/toxsci/kft278,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Comparison of hepatic transcription profiles of locked ribonucleic acid antisense oligonucleotides: evidence of distinct pathways contributing to non-target mediated toxicity in mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Comparison of hepatic transcription profiles of locked ribonucleic acid antisense oligonucleotides: evidence of distinct pathways contributing to non-target mediated toxicity in mice.
1518,3694,23610963,,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cytotoxicity of etoposide in cancer cell lines in vitro after BCL-2 and C-RAF gene silencing with antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cytotoxicity of etoposide in cancer cell lines in vitro after BCL-2 and C-RAF gene silencing with antisense oligonucleotides.
1521,3701,20110565,10.1177/1091581809359206,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Safety pharmacology and genotoxicity evaluation of AVI-4658.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety pharmacology and genotoxicity evaluation of AVI-4658.
1522,3704,38176263,10.1016/j.biomaterials.2023.122432,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: RNA four-way junction (4WJ) for spontaneous cancer-targeting, effective tumor-regression, metastasis suppression, fast renal excretion and undetectable toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"RNA four-way junction (4WJ) for spontaneous cancer-targeting, effective tumor-regression, metastasis suppression, fast renal excretion and undetectable toxicity."
1523,3707,37310263,10.1128/jvi.00652-23,toxicity,ASO/siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Analysis of the Contribution of 6-mer Seed Toxicity to HIV-1-Induced Cytopathicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Analysis of the Contribution of 6-mer Seed Toxicity to HIV-1-Induced Cytopathicity.
1524,3708,37310263,10.1128/jvi.00652-23,offtarget,ASO/siRNA,PubMed abstract sentence 14,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: Analysis of the Contribution of 6-mer Seed Toxicity to HIV-1-Induced Cytopathicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Analysis of the Contribution of 6-mer Seed Toxicity to HIV-1-Induced Cytopathicity.
1528,3718,33800744,10.3390/toxins13030190,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Transcriptome Analysis Reveals the AhR, Smad2/3, and HIF-1α Pathways as the Mechanism of Ochratoxin A Toxicity in Kidney Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Transcriptome Analysis Reveals the AhR, Smad2/3, and HIF-1α Pathways as the Mechanism of Ochratoxin A Toxicity in Kidney Cells."
1532,3724,33534636,10.1089/nat.2020.0923,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Solid-Phase Separation of Toxic Phosphorothioate Antisense Oligonucleotide-Protein Nucleolar Aggregates Is Cytoprotective.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Solid-Phase Separation of Toxic Phosphorothioate Antisense Oligonucleotide-Protein Nucleolar Aggregates Is Cytoprotective.
1533,3727,26983026,10.1089/nat.2015.0598,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Comparative Renal Toxicopathology of Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comparative Renal Toxicopathology of Antisense Oligonucleotides.
1537,3735,41439881,10.3390/biomimetics10120812,delivery,siRNA,PubMed abstract sentence 11,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Biocompatible Copolymerized Gold Nanoclusters: Anti-TNF-α siRNA Binding, Cellular Uptake, Cytotoxicity, Oxidative Stress and Cell Cycle Effects In Vitro.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Biocompatible Copolymerized Gold Nanoclusters: Anti-TNF-α siRNA Binding, Cellular Uptake, Cytotoxicity, Oxidative Stress and Cell Cycle Effects In Vitro."
1538,3736,41439881,10.3390/biomimetics10120812,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Biocompatible Copolymerized Gold Nanoclusters: Anti-TNF-α siRNA Binding, Cellular Uptake, Cytotoxicity, Oxidative Stress and Cell Cycle Effects In Vitro.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Biocompatible Copolymerized Gold Nanoclusters: Anti-TNF-α siRNA Binding, Cellular Uptake, Cytotoxicity, Oxidative Stress and Cell Cycle Effects In Vitro."
1542,3744,40911569,10.1371/journal.pone.0327375,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Upscaling, toxicity and efficacy of multifaceted dressing embedded with dsirna-loaded gold nanoparticles for enhancing diabetic wound treatment.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Upscaling, toxicity and efficacy of multifaceted dressing embedded with dsirna-loaded gold nanoparticles for enhancing diabetic wound treatment."
1543,3747,40800004,10.1016/j.omton.2025.201020,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Allele-specific depletion of GNAQ (Q209L) via siRNA or an rAAV2-shRNA vector induces selective toxicity in GNAQ (Q209L) uveal melanoma cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Allele-specific depletion of GNAQ (Q209L) via siRNA or an rAAV2-shRNA vector induces selective toxicity in GNAQ (Q209L) uveal melanoma cells.
1546,3754,40445609,10.1089/nat.2025.0013,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Developmental and Reproductive Toxicity Testing Strategies for Oligonucleotides: A Workshop Proceedings.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Developmental and Reproductive Toxicity Testing Strategies for Oligonucleotides: A Workshop Proceedings.
1547,3757,40158615,10.1016/j.lfs.2025.123595,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: SiRNA-mediated knockdown of TOP2B protects hiPSC-derived cardiomyocytes from doxorubicin-induced toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SiRNA-mediated knockdown of TOP2B protects hiPSC-derived cardiomyocytes from doxorubicin-induced toxicity.
1549,3761,39602529,10.1126/sciadv.adq3350,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inflammatory cytokines disrupt astrocyte exosomal HepaCAM-mediated protection against neuronal excitotoxicity in the SOD1G93A ALS model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inflammatory cytokines disrupt astrocyte exosomal HepaCAM-mediated protection against neuronal excitotoxicity in the SOD1G93A ALS model.
1552,3766,39539730,10.1016/j.bioactmat.2024.06.008,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gelatin and lipidoid integrate to create gelasomes to enhance siRNA delivery with low toxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Gelatin and lipidoid integrate to create gelasomes to enhance siRNA delivery with low toxicity.
1553,3769,30820542,10.1093/nar/gkz140,chemistry,siRNA,PubMed abstract sentence 2,chemical;modification;galnac;lna;conjugate,"chemistry candidate; matched derived terms: chemical, modification, galnac, lna, conjugate; source title: Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.
1554,3770,30820542,10.1093/nar/gkz140,delivery,siRNA,PubMed abstract sentence 2,delivery;galnac;conjugated,"delivery candidate; matched derived terms: delivery, galnac, conjugated; source title: Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.
1558,3776,28325303,10.1016/j.omtn.2016.11.006,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.
1559,3779,27923110,10.1089/nat.2016.0639,chemistry,ASO,PubMed abstract sentence 1,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Impact of Oligonucleotide Structure, Chemistry, and Delivery Method on In Vitro Cytotoxicity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Impact of Oligonucleotide Structure, Chemistry, and Delivery Method on In Vitro Cytotoxicity."
1560,3780,27923110,10.1089/nat.2016.0639,delivery,ASO,PubMed abstract sentence 9,conjugated;uptake,"delivery candidate; matched derived terms: conjugated, uptake; source title: Impact of Oligonucleotide Structure, Chemistry, and Delivery Method on In Vitro Cytotoxicity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Impact of Oligonucleotide Structure, Chemistry, and Delivery Method on In Vitro Cytotoxicity."
1561,3781,27923110,10.1089/nat.2016.0639,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Impact of Oligonucleotide Structure, Chemistry, and Delivery Method on In Vitro Cytotoxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Impact of Oligonucleotide Structure, Chemistry, and Delivery Method on In Vitro Cytotoxicity."
1565,3787,23308382,10.1089/nat.2012.0404,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Systemic delivery of a Peptide-linked morpholino oligonucleotide neutralizes mutant RNA toxicity in a mouse model of myotonic dystrophy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Systemic delivery of a Peptide-linked morpholino oligonucleotide neutralizes mutant RNA toxicity in a mouse model of myotonic dystrophy.
1574,3804,35862554,10.1080/1062936X.2022.2098814,assay,ASO/siRNA,PubMed abstract sentence 2,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Prediction of acute toxicity to Daphnia magna and interspecific correlation: a global QSAR model and a Daphnia-minnow QTTR model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prediction of acute toxicity to Daphnia magna and interspecific correlation: a global QSAR model and a Daphnia-minnow QTTR model.
1575,3805,35862554,10.1080/1062936X.2022.2098814,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Prediction of acute toxicity to Daphnia magna and interspecific correlation: a global QSAR model and a Daphnia-minnow QTTR model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Prediction of acute toxicity to Daphnia magna and interspecific correlation: a global QSAR model and a Daphnia-minnow QTTR model.
1576,3806,35862554,10.1080/1062936X.2022.2098814,benchmark,ASO/siRNA,PubMed abstract sentence 3,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Prediction of acute toxicity to Daphnia magna and interspecific correlation: a global QSAR model and a Daphnia-minnow QTTR model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prediction of acute toxicity to Daphnia magna and interspecific correlation: a global QSAR model and a Daphnia-minnow QTTR model.
1577,3809,34388351,10.1089/nat.2020.0921,offtarget,ASO,PubMed abstract sentence 2,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides.
1578,3812,33928567,10.1007/978-1-0716-1298-9_2,chemistry,siRNA,PubMed abstract sentence 4,modification;2'-o,"chemistry candidate; matched derived terms: modification, 2'-o; source title: Selection of Chemical Modifications in the siRNA Seed Region That Repress Off-Target Effect.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Selection of Chemical Modifications in the siRNA Seed Region That Repress Off-Target Effect.
1579,3813,33928567,10.1007/978-1-0716-1298-9_2,offtarget,siRNA,PubMed abstract sentence 4,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Selection of Chemical Modifications in the siRNA Seed Region That Repress Off-Target Effect.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Selection of Chemical Modifications in the siRNA Seed Region That Repress Off-Target Effect.
1581,3819,29565739,10.1089/nat.2017.0705,chemistry,ASO,PubMed abstract sentence 4,modified;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: modified, phosphorothioate, 2'-o; source title: Intracerebroventricular Administration of a 2'-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intracerebroventricular Administration of a 2'-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain.
1583,3823,29450406,10.1021/acsomega.7b00291,chemistry,siRNA,PubMed abstract sentence 1,chemical;modification;2'-o;lna,"chemistry candidate; matched derived terms: chemical, modification, 2'-o, lna; source title: Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets.
1584,3824,29450406,10.1021/acsomega.7b00291,offtarget,siRNA,PubMed abstract sentence 1,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets.
1585,3827,23344236,10.1038/mtna.2012.38,chemistry,ASO,PubMed abstract sentence 4,phosphorothioate;2'-o,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o; source title: Long-term Exon Skipping Studies With 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in Dystrophic Mouse Models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Long-term Exon Skipping Studies With 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in Dystrophic Mouse Models.
1586,3828,23344236,10.1038/mtna.2012.38,assay,ASO,PubMed abstract sentence 1,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Long-term Exon Skipping Studies With 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in Dystrophic Mouse Models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Long-term Exon Skipping Studies With 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in Dystrophic Mouse Models.
1588,3832,42194024,10.3390/biom16050674,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Activation of the Nrf2/ARE Pathway Attenuates BDE-47-Induced Immunotoxicity in RAW264.7 Macrophages.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Activation of the Nrf2/ARE Pathway Attenuates BDE-47-Induced Immunotoxicity in RAW264.7 Macrophages.
1589,3835,42176635,10.1016/j.ecoenv.2026.120301,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Melatonin alleviates fluoride-induced developmental neurotoxicity by restoring SIRT3/HIF-1α axis-mediated mitochondrial dysfunction and reversing energy metabolism reprogramming.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Melatonin alleviates fluoride-induced developmental neurotoxicity by restoring SIRT3/HIF-1α axis-mediated mitochondrial dysfunction and reversing energy metabolism reprogramming.
1590,3838,42126744,10.1007/s12012-026-10121-y,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: KLF9 Aggravates Doxorubicin-Induced Cardiotoxicity by Regulating the ROS/p53 Signalling Pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,KLF9 Aggravates Doxorubicin-Induced Cardiotoxicity by Regulating the ROS/p53 Signalling Pathway.
1591,3841,41950654,10.1016/j.plaphy.2026.111257,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Brassinosteroid (BR) alleviates Al toxicity in rice (Oryza sativa) through a gibberellic acid (GA) dependent pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Brassinosteroid (BR) alleviates Al toxicity in rice (Oryza sativa) through a gibberellic acid (GA) dependent pathway.
1594,3848,41797121,10.1016/j.jhazmat.2026.141676,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Kynurenine pathway mediated multi-generational neurotoxicity induced by fluoride exposure in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Kynurenine pathway mediated multi-generational neurotoxicity induced by fluoride exposure in Caenorhabditis elegans.
1595,3851,41780740,10.1016/j.ejphar.2026.178709,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Artesunate ameliorates doxorubicin-induced cardiotoxicity by promoting HuR binding to Sirt1 mRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Artesunate ameliorates doxorubicin-induced cardiotoxicity by promoting HuR binding to Sirt1 mRNA.
1596,3854,41775233,10.1016/j.jep.2026.121464,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ginsenoside Rg1 attenuates PM(2.5)-induced neurotoxicity by suppressing ferroptosis via the Nrf2/GPx4 axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ginsenoside Rg1 attenuates PM(2.5)-induced neurotoxicity by suppressing ferroptosis via the Nrf2/GPx4 axis.
1597,3857,41771771,10.1177/10742484261428559,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Eleutheroside E Attenuates Doxorubicin-Induced Cardiotoxicity by Suppressing Ferroptosis Through Activation of the Nrf2/SLC7A11/GPX4 Signaling Pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Eleutheroside E Attenuates Doxorubicin-Induced Cardiotoxicity by Suppressing Ferroptosis Through Activation of the Nrf2/SLC7A11/GPX4 Signaling Pathway.
1599,3863,41698483,10.1016/j.bcp.2026.117816,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pharmacological activation of GPX4 by selenomethionine attenuates cisplatin-induced ototoxicity and hearing loss.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pharmacological activation of GPX4 by selenomethionine attenuates cisplatin-induced ototoxicity and hearing loss.
1600,3866,41661698,10.1177/08853282261422858,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Se nanoparticles-coated, PLGA-based spheres for biomedical applications: Cytotoxicity, genotoxicity, oxidative stress, biodistribution, and scintigraphic study.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Se nanoparticles-coated, PLGA-based spheres for biomedical applications: Cytotoxicity, genotoxicity, oxidative stress, biodistribution, and scintigraphic study."
1602,3868,41661698,10.1177/08853282261422858,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Se nanoparticles-coated, PLGA-based spheres for biomedical applications: Cytotoxicity, genotoxicity, oxidative stress, biodistribution, and scintigraphic study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Se nanoparticles-coated, PLGA-based spheres for biomedical applications: Cytotoxicity, genotoxicity, oxidative stress, biodistribution, and scintigraphic study."
1603,3871,41654146,10.1016/j.freeradbiomed.2026.02.009,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Protective effect of resveratrol against colistin-induced nephrotoxicity through regulating Nrf2 pathway and inhibiting ferroptosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Protective effect of resveratrol against colistin-induced nephrotoxicity through regulating Nrf2 pathway and inhibiting ferroptosis.
1604,3874,41564769,10.1016/j.jhazmat.2026.141159,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: SMART strategy-driven engineering of multifunctional aptamers: Multifaceted applications in biosensing, toxicity masking, and sustained-release antibacterial.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"SMART strategy-driven engineering of multifunctional aptamers: Multifaceted applications in biosensing, toxicity masking, and sustained-release antibacterial."
1605,3877,41533771,10.7554/eLife.104691,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity.
1607,3881,41483840,10.1016/j.tox.2026.154395,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In vivo high-throughput toxicity screening of brominated flame retardants using a Caenorhabditis elegans transcription factor RNAi platform.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In vivo high-throughput toxicity screening of brominated flame retardants using a Caenorhabditis elegans transcription factor RNAi platform.
1610,3888,41391787,10.1016/j.envpol.2025.127528,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: 6-PPD quinone inhibits ammonia excretion to cause multiple aspects of toxicity in Caenorhabditis elegans by activating dual oxidase complex-SKN-1 axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,6-PPD quinone inhibits ammonia excretion to cause multiple aspects of toxicity in Caenorhabditis elegans by activating dual oxidase complex-SKN-1 axis.
1612,3894,41028239,10.1007/s00204-025-04211-z,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting cobra venom cytotoxin: a linear 40-mer ssDNA aptamer-based antivenom confers neutralisation potentials against cobra venom-induced cytotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting cobra venom cytotoxin: a linear 40-mer ssDNA aptamer-based antivenom confers neutralisation potentials against cobra venom-induced cytotoxicity.
1613,3897,41507703,10.19540/j.cnki.cjcmm.20250409.706,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: [Mechanism of triptolide-induced hepatic cell lipotoxicity based on lipophagy].",B,high_candidate,curator_rejected,reject,derived_annotations_only,[Mechanism of triptolide-induced hepatic cell lipotoxicity based on lipophagy].
1614,3900,41463321,10.3390/biom15121665,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Developmental Toxicity of Ibrutinib: Insights from Stem Cell Dynamics and Neural Regeneration in Planarians.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Developmental Toxicity of Ibrutinib: Insights from Stem Cell Dynamics and Neural Regeneration in Planarians.
1615,3903,41387695,10.1038/s41420-025-02901-2,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity.
1616,3906,41366456,10.1186/s13578-025-01479-7,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates.
1617,3909,41322074,10.1016/j.crtox.2025.100262,assay,ASO/siRNA,PubMed abstract sentence 12,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m(6)A RNA regulation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m(6)A RNA regulation.
1618,3910,41322074,10.1016/j.crtox.2025.100262,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m(6)A RNA regulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m(6)A RNA regulation.
1620,3914,41296099,10.1007/s12035-025-05400-8,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of SIRT1/PGC-1α Axis Exacerbates Fluorine and Aluminium Induced Neurotoxicity via Drp1-dependent Aggravated Mitochondrial Fission.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of SIRT1/PGC-1α Axis Exacerbates Fluorine and Aluminium Induced Neurotoxicity via Drp1-dependent Aggravated Mitochondrial Fission.
1621,3917,41231272,10.1007/s00018-025-05905-4,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: AICAr Inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and protection against doxorubicin toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,AICAr Inhibition of cardiomyocyte autophagy promotes p62-dependent NRF2 expression and protection against doxorubicin toxicity.
1622,3920,41209002,10.3389/fimmu.2025.1668066,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.
1624,3924,41138420,10.1016/j.jhazmat.2025.140148,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A new insight into the mechanism of DEHP-induced cardiotoxicity: Triggering pyroptosis of cardiomyocytes by disrupting sphingolipid metabolism.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A new insight into the mechanism of DEHP-induced cardiotoxicity: Triggering pyroptosis of cardiomyocytes by disrupting sphingolipid metabolism.
1626,3928,41111237,10.1021/acs.biomac.5c01014,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Glutathione-Responsive Polyhomocysteine Derivatives with Ultralow Toxicity toward Therapeutic Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Glutathione-Responsive Polyhomocysteine Derivatives with Ultralow Toxicity toward Therapeutic Delivery.
1628,3932,41108994,10.1016/j.bbrc.2025.152807,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ornithine decarboxylase 1 modulation regulates plasma membrane integrity and associated gene networks under glucotoxicity and lipotoxicity stress: An in vitro study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ornithine decarboxylase 1 modulation regulates plasma membrane integrity and associated gene networks under glucotoxicity and lipotoxicity stress: An in vitro study.
1629,3935,40976979,10.14814/phy2.70400,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Dietary influences on chemotherapy sensitivity and cardiotoxicity modulated by IRE1 targeting in triple-negative breast cancer in female mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dietary influences on chemotherapy sensitivity and cardiotoxicity modulated by IRE1 targeting in triple-negative breast cancer in female mice.
1630,3938,40916238,10.1016/j.phymed.2025.157220,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: 20-Deoxyingenol attenuated doxorubicin-induced cardiotoxicity by promoting autolysosome degradation through the UCHL3-TFEB pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,20-Deoxyingenol attenuated doxorubicin-induced cardiotoxicity by promoting autolysosome degradation through the UCHL3-TFEB pathway.
1631,3941,40915831,10.1016/j.pestbp.2025.106571,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ATP synthase subunit γ mediates Cry1Ac binding and toxicity in Grapholita molesta.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ATP synthase subunit γ mediates Cry1Ac binding and toxicity in Grapholita molesta.
1633,3945,40891651,10.1002/jbt.70480,assay,ASO/siRNA,PubMed abstract sentence 4,assay;model,"assay candidate; matched derived terms: assay, model; source title: ZnO Nanoparticles Interacts With Unique Serum Proteins and Induce Stress Signaling During Hepatoxicity - A Proteomics and Molecular Pathways Study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,ZnO Nanoparticles Interacts With Unique Serum Proteins and Induce Stress Signaling During Hepatoxicity - A Proteomics and Molecular Pathways Study.
1634,3946,40891651,10.1002/jbt.70480,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: ZnO Nanoparticles Interacts With Unique Serum Proteins and Induce Stress Signaling During Hepatoxicity - A Proteomics and Molecular Pathways Study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ZnO Nanoparticles Interacts With Unique Serum Proteins and Induce Stress Signaling During Hepatoxicity - A Proteomics and Molecular Pathways Study.
1635,3949,40888963,10.1007/s10142-025-01690-2,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MED12-STAT1-TAP2 axis regulates CD8 + T cell cytotoxicity and mediates immunotherapy outcome in non-small cell lung cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,MED12-STAT1-TAP2 axis regulates CD8 + T cell cytotoxicity and mediates immunotherapy outcome in non-small cell lung cancer.
1640,3958,40880646,10.3389/fphar.2025.1593290,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Mechanisms of sorafenib-induced cardiotoxicity: ER stress induces upregulation of ATF3, leading to downregulation of NDUFS1 expression and mitochondrial dysfunction.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Mechanisms of sorafenib-induced cardiotoxicity: ER stress induces upregulation of ATF3, leading to downregulation of NDUFS1 expression and mitochondrial dysfunction."
1642,3962,40877522,10.1007/978-1-0716-4742-4_25,offtarget,siRNA,PubMed abstract sentence 2,off-target;unintended,"offtarget candidate; matched derived terms: off-target, unintended; source title: Chemical Strategies to Enhance Antisense Strand Selection and Minimize Off-Target Effect-Mediated by siRNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chemical Strategies to Enhance Antisense Strand Selection and Minimize Off-Target Effect-Mediated by siRNAs.
1643,3965,40863953,10.3390/toxics13080677,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lycium barbarum Polysaccharide Improves Iron Homeostasis in Spermatocytes and Sertoli Cells via NRF2 to Alleviate DEHP-Induced Male Reproductive Toxicity in Mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lycium barbarum Polysaccharide Improves Iron Homeostasis in Spermatocytes and Sertoli Cells via NRF2 to Alleviate DEHP-Induced Male Reproductive Toxicity in Mice.
1645,3969,40850687,10.1016/j.impact.2025.100582,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: High-throughput screening of combined toxicity of nanoplastics and coexisting pollutants using luminescent bacterium.",B,high_candidate,curator_rejected,reject,derived_annotations_only,High-throughput screening of combined toxicity of nanoplastics and coexisting pollutants using luminescent bacterium.
1646,3972,40839771,10.1093/genetics/iyaf173,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Extreme QTL mapping enables the identification of novel zinc toxicity response loci in Drosophila melanogaster.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Extreme QTL mapping enables the identification of novel zinc toxicity response loci in Drosophila melanogaster.
1648,3976,40839015,10.1097/JS9.0000000000003213,assay,ASO/siRNA,PubMed abstract sentence 5,assay;model,"assay candidate; matched derived terms: assay, model; source title: Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma.
1649,3977,40839015,10.1097/JS9.0000000000003213,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma.
1652,3982,40806643,10.3390/ijms26157515,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Molecular Mechanisms of Cadmium-Induced Toxicity and Its Modification.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Molecular Mechanisms of Cadmium-Induced Toxicity and Its Modification.
1654,3986,40805803,10.3390/plants14152453,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Biochar and Melatonin Partnership Mitigates Arsenic Toxicity in Rice by Modulating Antioxidant Defense, Phytochelatin Synthesis, and Down-Regulating the Transporters Involved in Arsenic Uptake.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Biochar and Melatonin Partnership Mitigates Arsenic Toxicity in Rice by Modulating Antioxidant Defense, Phytochelatin Synthesis, and Down-Regulating the Transporters Involved in Arsenic Uptake."
1655,3989,40779962,10.1016/j.cellimm.2025.105011,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: METTL3 positively regulates the development and cytotoxicity of human embryonic stem cells-derived NK cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,METTL3 positively regulates the development and cytotoxicity of human embryonic stem cells-derived NK cells.
1656,3992,40725329,10.3390/insects16070699,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Insights into Lead Toxicity and Detoxification Mechanisms in the Silkworm, Bombyx mori.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Insights into Lead Toxicity and Detoxification Mechanisms in the Silkworm, Bombyx mori."
1657,3995,40611908,10.1101/2025.06.12.659401,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: High-throughput genetic mapping discovers novel zinc toxicity response loci in Drosophila melanogaster.",B,high_candidate,curator_rejected,reject,derived_annotations_only,High-throughput genetic mapping discovers novel zinc toxicity response loci in Drosophila melanogaster.
1659,3999,40500698,10.1186/s10020-025-01283-6,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2.
1660,4002,40494827,10.1021/acs.langmuir.5c00350,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Optimizing Branch Morphology in Gold Nanostars To Improve HER2-Targeted Cytotoxicity in HER2-Overexpressing Cancer Cells in the Presence of Serum Proteins.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimizing Branch Morphology in Gold Nanostars To Improve HER2-Targeted Cytotoxicity in HER2-Overexpressing Cancer Cells in the Presence of Serum Proteins.
1661,4003,40494827,10.1021/acs.langmuir.5c00350,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Optimizing Branch Morphology in Gold Nanostars To Improve HER2-Targeted Cytotoxicity in HER2-Overexpressing Cancer Cells in the Presence of Serum Proteins.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Optimizing Branch Morphology in Gold Nanostars To Improve HER2-Targeted Cytotoxicity in HER2-Overexpressing Cancer Cells in the Presence of Serum Proteins.
1662,4006,40311471,10.1016/j.ecoenv.2025.118245,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Profiling of lincRNAs and differential regulatory mechanisms in response to nanoplastic toxicity at environmentally relevant concentrations in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Profiling of lincRNAs and differential regulatory mechanisms in response to nanoplastic toxicity at environmentally relevant concentrations in Caenorhabditis elegans.
1663,4009,40294674,10.1016/j.ijbiomac.2025.143549,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment."
1664,4012,40245702,10.1016/j.redox.2025.103628,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting LINC00707 by vitamin D3 attenuates nitrogen mustard-caused dermal toxicity through inhibiting ferroptosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting LINC00707 by vitamin D3 attenuates nitrogen mustard-caused dermal toxicity through inhibiting ferroptosis.
1665,4015,40209314,10.1016/j.intimp.2025.114621,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A novel anti-PD-L1 DNA aptamer, Apta35 enhances non-small cell lung cancer cell cytotoxicity and apoptosis through lung cancer-activated T lymphocytes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"A novel anti-PD-L1 DNA aptamer, Apta35 enhances non-small cell lung cancer cell cytotoxicity and apoptosis through lung cancer-activated T lymphocytes."
1668,4024,39808388,10.1007/s12640-024-00725-z,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Differentially Expressed Nedd4-binding Protein Ndfip1 Protects Neurons Against Methamphetamine-induced Neurotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Differentially Expressed Nedd4-binding Protein Ndfip1 Protects Neurons Against Methamphetamine-induced Neurotoxicity.
1672,4034,39094399,10.1016/j.redox.2024.103293,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CREG1 attenuates doxorubicin-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CREG1 attenuates doxorubicin-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes.
1674,4038,38984864,10.1039/d4nr01357c,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Modulating efficacy and cytotoxicity of lipoamino fatty acid nucleic acid carriers using disulfide or hydrophobic spacers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Modulating efficacy and cytotoxicity of lipoamino fatty acid nucleic acid carriers using disulfide or hydrophobic spacers.
1677,4047,38877291,10.1111/imcb.12793,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transcriptional network analysis of peripheral blood leukocyte subsets in multiple sclerosis identifies a pathogenic role for a cytotoxicity-associated gene network in myeloid cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transcriptional network analysis of peripheral blood leukocyte subsets in multiple sclerosis identifies a pathogenic role for a cytotoxicity-associated gene network in myeloid cells.
1678,4050,38636406,10.1016/j.ecoenv.2024.116330,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identifying piRNAs that regulate BaP-induced lung injuries: A bottom-up approach from toxicity pathway investigation to animal validation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identifying piRNAs that regulate BaP-induced lung injuries: A bottom-up approach from toxicity pathway investigation to animal validation.
1679,4053,38535940,10.3390/toxics12030207,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Persulfate-Based Advanced Oxidation Process for Chlorpyrifos Degradation: Mechanism, Kinetics, and Toxicity Assessment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Persulfate-Based Advanced Oxidation Process for Chlorpyrifos Degradation: Mechanism, Kinetics, and Toxicity Assessment."
1680,4056,38433000,10.5650/jos.ess23089,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Neuroprotective Effect of Sophocarpine against Glutamate-Induced HT22 Cell Cytotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Neuroprotective Effect of Sophocarpine against Glutamate-Induced HT22 Cell Cytotoxicity.
1681,4059,38369182,10.1016/j.preteyeres.2024.101248,assay,ASO/siRNA,PubMed abstract sentence 6,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Pluripotent stem cell-derived models of retinal disease: Elucidating pathogenesis, evaluating novel treatments, and estimating toxicity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Pluripotent stem cell-derived models of retinal disease: Elucidating pathogenesis, evaluating novel treatments, and estimating toxicity."
1682,4060,38369182,10.1016/j.preteyeres.2024.101248,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pluripotent stem cell-derived models of retinal disease: Elucidating pathogenesis, evaluating novel treatments, and estimating toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Pluripotent stem cell-derived models of retinal disease: Elucidating pathogenesis, evaluating novel treatments, and estimating toxicity."
1684,4064,38330714,10.1016/j.watres.2024.121230,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Recovery mechanism of bio-promoters on Cr(VI) suppressed denitrification: Toxicity remediation and enhanced electron transmission.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Recovery mechanism of bio-promoters on Cr(VI) suppressed denitrification: Toxicity remediation and enhanced electron transmission.
1685,4067,38154547,10.1016/j.bcp.2023.116009,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice.
1686,4070,38039790,10.1016/j.ejmech.2023.115988,chemistry,ASO/siRNA,PubMed abstract sentence 3,modification;conjugate,"chemistry candidate; matched derived terms: modification, conjugate; source title: Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated cellular uptake and cytotoxicity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated cellular uptake and cytotoxicity."
1688,4072,38039790,10.1016/j.ejmech.2023.115988,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated cellular uptake and cytotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated cellular uptake and cytotoxicity."
1689,4075,37838222,10.1016/j.taap.2023.116713,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Angiotensin IV ameliorates doxorubicin-induced cardiotoxicity by increasing glutathione peroxidase 4 and alleviating ferroptosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Angiotensin IV ameliorates doxorubicin-induced cardiotoxicity by increasing glutathione peroxidase 4 and alleviating ferroptosis.
1691,4079,37571660,10.3390/s23156877,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: High-Throughput Effect-Directed Monitoring Platform for Specific Toxicity Quantification of Unknown Waters: Lead-Caused Cell Damage as a Model Using a DNA Hybrid Chain-Reaction-Induced AuNPs@aptamer Self-Assembly Assay.",B,high_candidate,curator_rejected,reject,derived_annotations_only,High-Throughput Effect-Directed Monitoring Platform for Specific Toxicity Quantification of Unknown Waters: Lead-Caused Cell Damage as a Model Using a DNA Hybrid Chain-Reaction-Induced AuNPs@aptamer Self-Assembly Assay.
1693,4083,37453609,10.1016/j.cbi.2023.110635,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The impact of solvents on the toxicity of the banned parathion insecticide.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The impact of solvents on the toxicity of the banned parathion insecticide.
1694,4086,37310350,10.1039/d3ob00574g,offtarget,ASO,PubMed abstract sentence 6,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: Alteration of target cleavage patterns and off-target reduction of antisense oligonucleotides incorporating 2-N-carbamoyl- or (2-pyridyl)guanine.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Alteration of target cleavage patterns and off-target reduction of antisense oligonucleotides incorporating 2-N-carbamoyl- or (2-pyridyl)guanine.
1695,4089,37063917,10.3389/fimmu.2023.1125948,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;dna damage,"toxicity candidate; matched derived terms: toxicity, toxic, dna damage; source title: Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity.
1697,4093,37040258,10.1021/acsabm.3c00155,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluation of Nonmodified Wireframe DNA Origami for Acute Toxicity and Biodistribution in Mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Evaluation of Nonmodified Wireframe DNA Origami for Acute Toxicity and Biodistribution in Mice.
1699,4099,37017313,10.1021/acs.est.2c09716,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Poly- and Perfluoroalkyl Substances Induce Immunotoxicity via the TLR Pathway in Zebrafish: Links to Carbon Chain Length.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Poly- and Perfluoroalkyl Substances Induce Immunotoxicity via the TLR Pathway in Zebrafish: Links to Carbon Chain Length.
1701,4103,36909507,10.1101/2023.02.25.530026,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluation of non-modified wireframe DNA origami for acute toxicity and biodistribution in mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Evaluation of non-modified wireframe DNA origami for acute toxicity and biodistribution in mice.
1705,4111,36707890,10.1186/s12967-023-03895-0,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The involvement and therapeutic potential of lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway in arsenic trioxide-induced cardiotoxicity.
1706,4114,36552710,10.3390/cells11243946,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Evaluation of Cardiovascular Toxicity of Folic Acid and 6S-5-Methyltetrahydrofolate-Calcium in Early Embryonic Development.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluation of Cardiovascular Toxicity of Folic Acid and 6S-5-Methyltetrahydrofolate-Calcium in Early Embryonic Development.
1707,4117,36442393,10.1016/j.redox.2022.102542,toxicity,ASO/siRNA,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling.
1709,4121,36270753,10.1136/bmjopen-2021-055718,toxicity,ASO,PubMed abstract sentence 6,safety;adverse;tolerability,"toxicity candidate; matched derived terms: safety, adverse, tolerability; source title: Safety, tolerability, pharmacokinetics and preliminary antitumour activity of an antisense oligonucleotide targeting STAT3 (danvatirsen) as monotherapy and in combination with durvalumab in Japanese patients with advanced solid malignancies: a phase 1 study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Safety, tolerability, pharmacokinetics and preliminary antitumour activity of an antisense oligonucleotide targeting STAT3 (danvatirsen) as monotherapy and in combination with durvalumab in Japanese patients with advanced solid malignancies: a phase 1 study."
1712,4126,35921069,10.1089/nat.2022.0024,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nucleic Acid Aptamers Increase the Anticancer Efficiency and Reduce the Toxicity of Cisplatin-Arabinogalactan Conjugates In Vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nucleic Acid Aptamers Increase the Anticancer Efficiency and Reduce the Toxicity of Cisplatin-Arabinogalactan Conjugates In Vivo.
1714,4132,35652794,10.1021/acs.est.1c08875,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish.
1715,4135,35608007,10.1080/10408444.2022.2065967,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Temephos, an organophosphate larvicide for residential use: a review of its toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Temephos, an organophosphate larvicide for residential use: a review of its toxicity."
1716,4138,35523292,10.1016/j.chemosphere.2022.134822,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Structure identification and toxicity evaluation of one newly-discovered dechlorinated photoproducts of chlorpyrifos.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Structure identification and toxicity evaluation of one newly-discovered dechlorinated photoproducts of chlorpyrifos.
1717,4141,35494247,10.1016/j.isci.2022.104246,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Asymmetric inheritance of RNA toxicity in C. elegans expressing CTG repeats.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Asymmetric inheritance of RNA toxicity in C. elegans expressing CTG repeats.
1718,4144,35464859,10.3389/fgene.2022.791416,chemistry,ASO,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro."
1720,4148,34890706,10.1016/j.tox.2021.153063,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pulmonary toxicity, cytotoxicity, and genotoxicity of submicron-diameter carbon fibers with different diameters and lengths.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Pulmonary toxicity, cytotoxicity, and genotoxicity of submicron-diameter carbon fibers with different diameters and lengths."
1722,4152,34663988,10.1038/s41591-021-01522-3,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain.
1723,4155,34327919,10.13345/j.cjb.200538,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: [Development of a novel high throughput brain-on-chip with 3D structure and its application in evaluation of pesticide-induced-neurotoxicity].",B,high_candidate,curator_rejected,reject,derived_annotations_only,[Development of a novel high throughput brain-on-chip with 3D structure and its application in evaluation of pesticide-induced-neurotoxicity].
1724,4158,33992596,10.1016/j.abb.2021.108918,toxicity,ASO,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tripartite-motif protein 21 knockdown extenuates LPS-triggered neurotoxicity by inhibiting microglial M1 polarization via suppressing NF-κB-mediated NLRP3 inflammasome activation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tripartite-motif protein 21 knockdown extenuates LPS-triggered neurotoxicity by inhibiting microglial M1 polarization via suppressing NF-κB-mediated NLRP3 inflammasome activation.
1725,4161,33977265,10.1093/braincomms/fcab053,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity.
1726,4164,33314011,10.1007/s40291-020-00504-4,offtarget,ASO,PubMed abstract sentence 3,off-target;unintended,"offtarget candidate; matched derived terms: off-target, unintended; source title: Using RNA-seq to Assess Off-Target Effects of Antisense Oligonucleotides in Human Cell Lines.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Using RNA-seq to Assess Off-Target Effects of Antisense Oligonucleotides in Human Cell Lines.
1727,4167,33154507,10.1038/s41598-020-76129-8,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification of early liver toxicity gene biomarkers using comparative supervised machine learning.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identification of early liver toxicity gene biomarkers using comparative supervised machine learning.
1729,4171,32966316,10.1371/journal.pone.0239540,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers.
1731,4177,32426239,10.1016/j.toxrep.2020.04.010,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MicroRNAs and Xenobiotic Toxicity: An Overview.",B,high_candidate,curator_rejected,reject,derived_annotations_only,MicroRNAs and Xenobiotic Toxicity: An Overview.
1735,4187,32127464,10.1158/1535-7163.MCT-19-0775,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma.
1736,4190,32108853,10.1042/BCJ20190676,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease.
1737,4193,31881528,10.1016/j.omtn.2019.11.020,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identifying and Avoiding tcDNA-ASO Sequence-Specific Toxicity for the Development of DMD Exon 51 Skipping Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Identifying and Avoiding tcDNA-ASO Sequence-Specific Toxicity for the Development of DMD Exon 51 Skipping Therapy.
1738,4196,31699484,10.1016/j.jhazmat.2019.121521,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos.",B,high_candidate,curator_rejected,reject,derived_annotations_only,AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos.
1739,4199,31144994,10.1080/17425255.2019.1621838,chemistry,ASO,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc(3)-Conjugated Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc(3)-Conjugated Antisense Oligonucleotides.
1740,4200,31144994,10.1080/17425255.2019.1621838,delivery,ASO,PubMed abstract sentence 1,galnac;conjugated;uptake,"delivery candidate; matched derived terms: galnac, conjugated, uptake; source title: Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc(3)-Conjugated Antisense Oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc(3)-Conjugated Antisense Oligonucleotides.
1742,4204,30570431,10.1089/nat.2018.0753,chemistry,ASO,PubMed abstract sentence 2,modified;phosphorothioate;galnac;2'-o;lna,"chemistry candidate; matched derived terms: modified, phosphorothioate, galnac, 2'-o, lna; source title: Integrated Assessment of the Clinical Performance of GalNAc(3)-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Integrated Assessment of the Clinical Performance of GalNAc(3)-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.
1743,4205,30570431,10.1089/nat.2018.0753,delivery,ASO,PubMed abstract sentence 7,delivery;galnac;conjugated,"delivery candidate; matched derived terms: delivery, galnac, conjugated; source title: Integrated Assessment of the Clinical Performance of GalNAc(3)-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Integrated Assessment of the Clinical Performance of GalNAc(3)-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.
1744,4206,30570431,10.1089/nat.2018.0753,assay,ASO,PubMed abstract sentence 10,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Integrated Assessment of the Clinical Performance of GalNAc(3)-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Integrated Assessment of the Clinical Performance of GalNAc(3)-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.
1745,4209,30139307,10.1177/0192623318792537,chemistry,siRNA,PubMed abstract sentence 4,chemical;modification;phosphorothioate;galnac;2'-o;lna,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate, galnac, 2'-o, lna; source title: The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies.
1746,4210,30139307,10.1177/0192623318792537,delivery,siRNA,PubMed abstract sentence 2,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies.
1748,4212,30139307,10.1177/0192623318792537,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies.
1749,4215,28929521,10.1111/bcp.13405,toxicity,ASO,PubMed abstract sentence 1,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Safety, tolerability, and pharmacokinetics of radavirsen (AVI-7100), an antisense oligonucleotide targeting influenza a M1/M2 translation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety, tolerability, and pharmacokinetics of radavirsen (AVI-7100), an antisense oligonucleotide targeting influenza a M1/M2 translation."
1750,4218,28853853,10.1021/acschembio.7b00416,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: BNA(NC) Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,BNA(NC) Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells.
1752,4222,28295562,10.1002/em.22076,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;risk;dna damage,"toxicity candidate; matched derived terms: toxicity, toxic, risk, dna damage; source title: Locked nucleic acid (LNA): Based single-stranded oligonucleotides are not genotoxic.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Locked nucleic acid (LNA): Based single-stranded oligonucleotides are not genotoxic.
1753,4225,28186253,10.1093/toxsci/kfx035,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Mechanistic Investigations Into the Developmental Toxicity of Nitrated and Heterocyclic PAHs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mechanistic Investigations Into the Developmental Toxicity of Nitrated and Heterocyclic PAHs.
1755,4229,28088213,10.1186/s13024-016-0146-8,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration.
1756,4230,28088213,10.1186/s13024-016-0146-8,benchmark,ASO/siRNA,PubMed abstract sentence 12,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration.
1758,4234,27576004,10.1016/j.taap.2016.08.024,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos.",B,high_candidate,curator_rejected,reject,derived_annotations_only,AHR2 morpholino knockdown reduces the toxicity of total particulate matter to zebrafish embryos.
1759,4237,27500733,10.1089/nat.2016.0623,chemistry,ASO,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.
1760,4238,27500733,10.1089/nat.2016.0623,delivery,ASO,PubMed abstract sentence 1,galnac;conjugated;uptake,"delivery candidate; matched derived terms: galnac, conjugated, uptake; source title: Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.
1763,4245,27311893,10.1016/j.bmcl.2016.06.012,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Design, synthesis, and evaluation of water-soluble morpholino-decorated paclitaxel prodrugs with remarkably decreased toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Design, synthesis, and evaluation of water-soluble morpholino-decorated paclitaxel prodrugs with remarkably decreased toxicity."
1764,4248,26678173,10.1016/j.bmc.2015.11.036,chemistry,ASO,PubMed abstract sentence 2,modified;galnac;lna,"chemistry candidate; matched derived terms: modified, galnac, lna; source title: Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides.
1766,4252,25500619,10.1016/j.aquatox.2014.11.018,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aryl hydrocarbon receptor 2 mediates the toxicity of Paclobutrazol on the digestive system of zebrafish embryos.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aryl hydrocarbon receptor 2 mediates the toxicity of Paclobutrazol on the digestive system of zebrafish embryos.
1768,4256,25035419,10.1093/hmg/ddu349,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity.
1770,4260,24806225,10.2144/000114167,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lessons learned from vivo-morpholinos: How to avoid vivo-morpholino toxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Lessons learned from vivo-morpholinos: How to avoid vivo-morpholino toxicity.
1771,4263,23451977,10.1517/14712598.2013.774366,chemistry,ASO,PubMed abstract sentence 4,chemical;modification;modified;phosphorothioate;lna,"chemistry candidate; matched derived terms: chemical, modification, modified, phosphorothioate, lna; source title: Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides.
1773,4265,23451977,10.1517/14712598.2013.774366,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides.
1774,4268,23416188,10.1016/j.bbalip.2013.02.002,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ubiquitous transcription factor YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 expression.
1775,4271,21040984,10.1016/j.aquatox.2010.09.016,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: AhR2-mediated, CYP1A-independent cardiovascular toxicity in zebrafish (Danio rerio) embryos exposed to retene.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"AhR2-mediated, CYP1A-independent cardiovascular toxicity in zebrafish (Danio rerio) embryos exposed to retene."
1776,4274,21687525,10.4161/adna.1.1.12204,chemistry,siRNA,PubMed abstract sentence 4,chemical;modification;modified,"chemistry candidate; matched derived terms: chemical, modification, modified; source title: In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts.
1777,4275,21687525,10.4161/adna.1.1.12204,offtarget,siRNA,PubMed abstract sentence 10,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts.
1778,4278,42160988,10.1016/j.jpba.2026.117572,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Quantification of PEG2000-DMG and TS-202, an ionic lipid, in rabbit plasma by LC-MS/MS: Application to complement C5 siRNA lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Quantification of PEG2000-DMG and TS-202, an ionic lipid, in rabbit plasma by LC-MS/MS: Application to complement C5 siRNA lipid nanoparticles."
1780,4282,41819640,10.1016/j.vaccine.2026.128437,assay,ASO,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: A narrative review of immune-mediated adverse events in clinical trials of CpG oligonucleotide toll-like receptor 9 agonists.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A narrative review of immune-mediated adverse events in clinical trials of CpG oligonucleotide toll-like receptor 9 agonists.
1781,4283,41819640,10.1016/j.vaccine.2026.128437,toxicity,ASO,PubMed abstract sentence 6,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: A narrative review of immune-mediated adverse events in clinical trials of CpG oligonucleotide toll-like receptor 9 agonists.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A narrative review of immune-mediated adverse events in clinical trials of CpG oligonucleotide toll-like receptor 9 agonists.
1782,4286,40526144,10.1021/acs.jafc.4c11433,offtarget,ASO/siRNA,PubMed abstract sentence 6,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: Using Transcriptome Diversity to Evaluate the Off-Target Effects of miRNA-Mediated Transgenic Rice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Using Transcriptome Diversity to Evaluate the Off-Target Effects of miRNA-Mediated Transgenic Rice.
1786,4296,36576400,10.1089/nat.2022.0055,chemistry,ASO,PubMed abstract sentence 1,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: SIDT2 Inhibits Phosphorothioate Antisense Oligonucleotide Activity by Regulating Cellular Localization of Lysosomes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,SIDT2 Inhibits Phosphorothioate Antisense Oligonucleotide Activity by Regulating Cellular Localization of Lysosomes.
1788,4302,35332222,10.1038/s41598-022-09051-w,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification of the toxic 6mer seed consensus for human cancer cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Identification of the toxic 6mer seed consensus for human cancer cells.
1790,4306,35071927,10.1021/acsomega.1c06455,chemistry,siRNA,PubMed abstract sentence 5,modification;2'-o,"chemistry candidate; matched derived terms: modification, 2'-o; source title: siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2'-OMe Modifications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2'-OMe Modifications.
1791,4307,35071927,10.1021/acsomega.1c06455,offtarget,siRNA,PubMed abstract sentence 2,seed;unintended,"offtarget candidate; matched derived terms: seed, unintended; source title: siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2'-OMe Modifications.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2'-OMe Modifications.
1795,4315,33801683,10.3390/ijms22073470,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Foxp3 Silencing with Antisense Oligonucleotide Improves Immunogenicity of an Adjuvanted Recombinant Vaccine against Sporothrix schenckii.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Foxp3 Silencing with Antisense Oligonucleotide Improves Immunogenicity of an Adjuvanted Recombinant Vaccine against Sporothrix schenckii.
1798,4320,31712839,10.1007/s00204-019-02612-5,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances.
1804,4332,30464402,10.2147/DDDT.S179008,chemistry,ASO,PubMed abstract sentence 2,phosphorothioate;2'-o,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o; source title: Saponins enhance exon skipping of 2'-O-methyl phosphorothioate oligonucleotide in vitro and in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Saponins enhance exon skipping of 2'-O-methyl phosphorothioate oligonucleotide in vitro and in vivo.
1805,4335,29425080,10.1089/nat.2017.0709,chemistry,ASO,PubMed abstract sentence 3,modification;modified;phosphorothioate,"chemistry candidate; matched derived terms: modification, modified, phosphorothioate; source title: Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver.
1809,4343,28627628,10.3892/mmr.2017.6778,chemistry,ASO,PubMed abstract sentence 2,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Phosphorothioate‑modified antisense oligonucleotides against human telomerase reverse transcriptase sensitize cancer cells to radiotherapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phosphorothioate‑modified antisense oligonucleotides against human telomerase reverse transcriptase sensitize cancer cells to radiotherapy.
1810,4346,28448194,10.1089/nat.2017.0662,chemistry,ASO,PubMed abstract sentence 1,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver.
1813,4351,26908652,10.1093/nar/gkw112,chemistry,ASO,PubMed abstract sentence 1,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver.
1816,4358,24131982,10.1038/gt.2013.57,chemistry,ASO,PubMed abstract sentence 1,phosphorothioate;2'-o;conjugate,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o, conjugate; source title: Pluronic-PEI copolymers enhance exon-skipping of 2'-O-methyl phosphorothioate oligonucleotide in cell culture and dystrophic mdx mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pluronic-PEI copolymers enhance exon-skipping of 2'-O-methyl phosphorothioate oligonucleotide in cell culture and dystrophic mdx mice.
1820,4366,20544786,10.1002/cmdc.201000156,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Off-target effects related to the phosphorothioate modification of nucleic acids.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Off-target effects related to the phosphorothioate modification of nucleic acids.
1822,4370,41936798,10.1016/j.ejmech.2026.118821,chemistry,ASO,PubMed abstract sentence 6,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: GalNAc-CPP conjugates improve the efficiency of oligonucleotide drugs in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-CPP conjugates improve the efficiency of oligonucleotide drugs in vivo.
1823,4371,41936798,10.1016/j.ejmech.2026.118821,delivery,ASO,PubMed abstract sentence 6,delivery;galnac;conjugated,"delivery candidate; matched derived terms: delivery, galnac, conjugated; source title: GalNAc-CPP conjugates improve the efficiency of oligonucleotide drugs in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-CPP conjugates improve the efficiency of oligonucleotide drugs in vivo.
1827,4379,41877501,10.1177/21593337261435980,chemistry,ASO,PubMed abstract sentence 3,galnac;lna,"chemistry candidate; matched derived terms: galnac, lna; source title: The Approval of Redemplo for Familial Chylomicronemia Syndrome and the Many Flavors of GalNAc-Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Approval of Redemplo for Familial Chylomicronemia Syndrome and the Many Flavors of GalNAc-Oligonucleotides.
1828,4380,41877501,10.1177/21593337261435980,delivery,ASO,PubMed abstract sentence 3,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: The Approval of Redemplo for Familial Chylomicronemia Syndrome and the Many Flavors of GalNAc-Oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Approval of Redemplo for Familial Chylomicronemia Syndrome and the Many Flavors of GalNAc-Oligonucleotides.
1829,4383,41755844,10.1021/jacsau.5c01765,chemistry,siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Taming the Achilles' Heel: A Chemical and Structural Design to Address Off-Target Effects in siRNA Therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Taming the Achilles' Heel: A Chemical and Structural Design to Address Off-Target Effects in siRNA Therapeutics.
1830,4384,41755844,10.1021/jacsau.5c01765,offtarget,siRNA,PubMed abstract sentence 8,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Taming the Achilles' Heel: A Chemical and Structural Design to Address Off-Target Effects in siRNA Therapeutics.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Taming the Achilles' Heel: A Chemical and Structural Design to Address Off-Target Effects in siRNA Therapeutics.
1834,4394,40977082,10.1002/anie.202511386,chemistry,ASO,PubMed abstract sentence 4,phosphorothioate;2'-o;lna,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o, lna; source title: Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA-Charge Neutral Linkages for Enhanced Splice-Switching Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA-Charge Neutral Linkages for Enhanced Splice-Switching Antisense Oligonucleotides."
1836,4398,40725043,10.3390/ijms26146795,benchmark,siRNA,PubMed abstract sentence 7,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: siRNA Features-Automated Machine Learning of 3D Molecular Fingerprints and Structures for Therapeutic Off-Target Data.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA Features-Automated Machine Learning of 3D Molecular Fingerprints and Structures for Therapeutic Off-Target Data.
1837,4401,40436308,10.1016/j.ahj.2025.05.014,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Design and rationale of the VICTORION-Difference study: A phase 4 randomized, double-blind, placebo-controlled clinical trial to assess inclisiran's early efficacy, safety, tolerability, as well as its impact on quality of life in individuals with hypercholesterolemia.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Design and rationale of the VICTORION-Difference study: A phase 4 randomized, double-blind, placebo-controlled clinical trial to assess inclisiran's early efficacy, safety, tolerability, as well as its impact on quality of life in individuals with hypercholesterolemia."
1840,4406,40392667,10.1016/j.jacc.2025.04.049,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Safety and Lipid-Lowering Efficacy of Inclisiran Monotherapy in Patients Without ASCVD: The VICTORION-Mono Randomized Clinical Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Safety and Lipid-Lowering Efficacy of Inclisiran Monotherapy in Patients Without ASCVD: The VICTORION-Mono Randomized Clinical Trial.
1849,4425,40160160,10.1111/cts.70207,toxicity,siRNA,PubMed abstract sentence 4,safety;adverse;tolerability,"toxicity candidate; matched derived terms: safety, adverse, tolerability; source title: A First-In-Human Phase 1 Study to Evaluate the Safety and Tolerability of LEM-S401, a Novel siRNA-DegradaBALL Drug Targeting CTGF in Healthy Adults.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"A First-In-Human Phase 1 Study to Evaluate the Safety and Tolerability of LEM-S401, a Novel siRNA-DegradaBALL Drug Targeting CTGF in Healthy Adults."
1851,4429,40116355,10.1111/cts.70202,toxicity,siRNA,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Pharmacokinetics and Safety Profile of SNS812, a First in Human Fully Modified siRNA Targeting Wide-Spectrum SARS-CoV-2, in Healthy Subjects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Pharmacokinetics and Safety Profile of SNS812, a First in Human Fully Modified siRNA Targeting Wide-Spectrum SARS-CoV-2, in Healthy Subjects."
1852,4432,40050561,10.1208/s12248-025-01023-y,assay,ASO,PubMed abstract sentence 8,experiment;phase,"assay candidate; matched derived terms: experiment, phase; source title: A Phase-Appropriate Risk Assessment Strategy in Support of the Safety of Peptide and Oligonucleotide-Related Impurities.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Phase-Appropriate Risk Assessment Strategy in Support of the Safety of Peptide and Oligonucleotide-Related Impurities.
1853,4433,40050561,10.1208/s12248-025-01023-y,toxicity,ASO,PubMed abstract sentence 5,toxic;safety;risk,"toxicity candidate; matched derived terms: toxic, safety, risk; source title: A Phase-Appropriate Risk Assessment Strategy in Support of the Safety of Peptide and Oligonucleotide-Related Impurities.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Phase-Appropriate Risk Assessment Strategy in Support of the Safety of Peptide and Oligonucleotide-Related Impurities.
1854,4436,39939158,10.1080/17425247.2025.2466767,chemistry,siRNA,PubMed abstract sentence 2,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases.
1855,4437,39939158,10.1080/17425247.2025.2466767,delivery,siRNA,PubMed abstract sentence 2,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases.
1857,4441,39897575,10.1016/j.omtn.2024.102435,assay,ASO/siRNA,PubMed abstract sentence 1,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Clinical trial to compare safety and tolerability between intravenous infusion and bolus intravenous injection of ApTOLL in healthy volunteers.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clinical trial to compare safety and tolerability between intravenous infusion and bolus intravenous injection of ApTOLL in healthy volunteers.
1861,4449,39692461,10.1039/d4mh01158a,offtarget,ASO,PubMed abstract sentence 5,mismatch;unintended,"offtarget candidate; matched derived terms: mismatch, unintended; source title: DNA nanotechnology-based strategies for minimising hybridisation-dependent off-target effects in oligonucleotide therapies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,DNA nanotechnology-based strategies for minimising hybridisation-dependent off-target effects in oligonucleotide therapies.
1862,4452,39645085,10.1016/j.jconrel.2024.11.074,delivery,ASO,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy.
1864,4456,39770048,10.3390/molecules29245959,chemistry,ASO,PubMed abstract sentence 1,chemical;modified;galnac;lna;conjugate,"chemistry candidate; matched derived terms: chemical, modified, galnac, lna, conjugate; source title: A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide.
1865,4457,39770048,10.3390/molecules29245959,delivery,ASO,PubMed abstract sentence 1,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide.
1867,4461,39243856,10.1016/j.eprac.2024.08.013,toxicity,ASO/siRNA,PubMed abstract sentence 5,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Safety and Efficacy of the Novel RNA Interference Therapies for Hypertriglyceridemia and Mixed Hyperlipidemia Management: A Systematic Review and Meta-analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety and Efficacy of the Novel RNA Interference Therapies for Hypertriglyceridemia and Mixed Hyperlipidemia Management: A Systematic Review and Meta-analysis.
1870,4468,38870677,10.1016/j.tranon.2024.102030,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome."
1872,4472,38563414,10.1111/cts.13784,toxicity,ASO,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers."
1874,4476,38308663,10.1111/pbi.14292,offtarget,ASO/siRNA,PubMed abstract sentence 3,seed;transcriptome,"offtarget candidate; matched derived terms: seed, transcriptome; source title: Homoeologous exchanges contribute to branch angle variations in rapeseed: Insights from transcriptome, QTL-seq and gene functional analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Homoeologous exchanges contribute to branch angle variations in rapeseed: Insights from transcriptome, QTL-seq and gene functional analysis."
1882,4492,37792433,10.1158/1078-0432.CCR-23-1456,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Safety and Efficacy of NY-ESO-1 Antigen-Specific T-Cell Receptor Gene-Transduced T Lymphocytes in Patients with Synovial Sarcoma: A Phase I/II Clinical Trial.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety and Efficacy of NY-ESO-1 Antigen-Specific T-Cell Receptor Gene-Transduced T Lymphocytes in Patients with Synovial Sarcoma: A Phase I/II Clinical Trial.
1885,4499,36415122,10.1002/cpdd.1197,toxicity,siRNA,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Pharmacokinetics, Safety, and Tolerability of the siRNA JNJ-73763989 in Healthy Chinese Adult Participants.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Pharmacokinetics, Safety, and Tolerability of the siRNA JNJ-73763989 in Healthy Chinese Adult Participants."
1887,4503,36412852,10.3390/jfb13040211,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PEGylated Strontium Sulfite Nanoparticles with Spontaneously Formed Surface-Embedded Protein Corona Restrict Off-Target Distribution and Accelerate Breast Tumour-Selective Delivery of siRNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,PEGylated Strontium Sulfite Nanoparticles with Spontaneously Formed Surface-Embedded Protein Corona Restrict Off-Target Distribution and Accelerate Breast Tumour-Selective Delivery of siRNA.
1890,4510,35404139,10.1089/nat.2021.0068,chemistry,siRNA,PubMed abstract sentence 2,modification;modified,"chemistry candidate; matched derived terms: modification, modified; source title: Elimination of Off-Target Effect by Chemical Modification of 5'-End of siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Elimination of Off-Target Effect by Chemical Modification of 5'-End of siRNA.
1891,4511,35404139,10.1089/nat.2021.0068,offtarget,siRNA,PubMed abstract sentence 5,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Elimination of Off-Target Effect by Chemical Modification of 5'-End of siRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Elimination of Off-Target Effect by Chemical Modification of 5'-End of siRNA.
1892,4514,35205363,10.3390/genes13020319,offtarget,siRNA,PubMed abstract sentence 2,seed;unintended,"offtarget candidate; matched derived terms: seed, unintended; source title: The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects.
1893,4517,34648028,10.1093/nar/gkab916,chemistry,siRNA,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.",B,high_candidate,curator_verified,accept,derived_annotations_only,Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
1895,4521,33928571,10.1007/978-1-0716-1298-9_6,chemistry,siRNA,PubMed abstract sentence 5,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: siRNA Design and GalNAc-Empowered Hepatic Targeted Delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA Design and GalNAc-Empowered Hepatic Targeted Delivery.
1896,4522,33928571,10.1007/978-1-0716-1298-9_6,delivery,siRNA,PubMed abstract sentence 5,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: siRNA Design and GalNAc-Empowered Hepatic Targeted Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA Design and GalNAc-Empowered Hepatic Targeted Delivery.
1901,4533,32515135,10.1002/ps.5957,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Food safety assessment of crops engineered with RNA interference and other methods to modulate expression of endogenous and plant pest genes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Food safety assessment of crops engineered with RNA interference and other methods to modulate expression of endogenous and plant pest genes.
1902,4536,31687889,10.1089/nat.2019.0780,chemistry,ASO,PubMed abstract sentence 3,chemical;2'-o,"chemistry candidate; matched derived terms: chemical, 2'-o; source title: Impurity Qualification Toxicology Study for a 2'-O-Methoxyethyl-Modified Antisense Inhibitor in Mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Impurity Qualification Toxicology Study for a 2'-O-Methoxyethyl-Modified Antisense Inhibitor in Mice.
1906,4546,31270142,10.1124/dmd.119.087098,chemistry,siRNA,PubMed abstract sentence 3,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters.
1907,4547,31270142,10.1124/dmd.119.087098,delivery,siRNA,PubMed abstract sentence 3,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters.
1908,4550,29846725,10.1093/toxsci/kfy119,chemistry,ASO,PubMed abstract sentence 1,modified;2'-o;2'-moe,"chemistry candidate; matched derived terms: modified, 2'-o, 2'-moe; source title: Investigation into the Mechanism(s) That Leads to Platelet Decreases in Cynomolgus Monkeys During Administration of ISIS 104838, a 2'-MOE-Modified Antisense Oligonucleotide.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Investigation into the Mechanism(s) That Leads to Platelet Decreases in Cynomolgus Monkeys During Administration of ISIS 104838, a 2'-MOE-Modified Antisense Oligonucleotide."
1910,4554,29499955,10.1016/j.omtn.2017.11.004,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic;risk;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, risk, hepatotoxicity; source title: A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides.
1912,4558,29246294,10.1016/j.omtn.2017.09.002,chemistry,ASO,PubMed abstract sentence 3,modified;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: modified, phosphorothioate, 2'-o; source title: Rational Design of Short Locked Nucleic Acid-Modified 2'-O-Methyl Antisense Oligonucleotides for Efficient Exon-Skipping In Vitro.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rational Design of Short Locked Nucleic Acid-Modified 2'-O-Methyl Antisense Oligonucleotides for Efficient Exon-Skipping In Vitro.
1916,4568,28129130,10.1016/j.ymthe.2016.10.019,chemistry,siRNA,PubMed abstract sentence 4,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate.
1917,4569,28129130,10.1016/j.ymthe.2016.10.019,delivery,siRNA,PubMed abstract sentence 3,galnac;uptake,"delivery candidate; matched derived terms: galnac, uptake; source title: Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate.
1920,4574,28123102,10.1093/toxsci/kfx025,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.
1926,4586,26444021,10.3233/JHD-150163,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model.
1929,4591,24321374,10.1016/j.nmd.2013.09.004,toxicity,ASO/siRNA,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Pharmacokinetics and safety of single doses of drisapersen in non-ambulant subjects with Duchenne muscular dystrophy: results of a double-blind randomized clinical trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Pharmacokinetics and safety of single doses of drisapersen in non-ambulant subjects with Duchenne muscular dystrophy: results of a double-blind randomized clinical trial.
1932,4598,23932248,10.1016/j.biomaterials.2013.07.019,chemistry,siRNA,PubMed abstract sentence 6,chemical;modification;phosphorothioate,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate; source title: Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery.
1933,4599,23932248,10.1016/j.biomaterials.2013.07.019,delivery,siRNA,PubMed abstract sentence 2,delivery;conjugated;uptake,"delivery candidate; matched derived terms: delivery, conjugated, uptake; source title: Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery.
1934,4600,23932248,10.1016/j.biomaterials.2013.07.019,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery.
1935,4603,23692080,10.1089/nat.2013.0422,chemistry,ASO,PubMed abstract sentence 10,modification;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: modification, phosphorothioate, 2'-o; source title: Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.
1937,4605,23692080,10.1089/nat.2013.0422,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.
1946,4624,41810468,10.1016/j.ajps.2026.101126,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In vivo self-assembled siRNAs targeting VEGFR2 and mTOR for renal cell carcinoma treatment.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In vivo self-assembled siRNAs targeting VEGFR2 and mTOR for renal cell carcinoma treatment.
1951,4635,41512647,10.1016/j.chroma.2025.466639,chemistry,siRNA,PubMed abstract sentence 1,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Decoding diastereomeric and impurity profiles of phosphorothioated siRNAs via 2D anion-exchange chromatography coupled with ion-pair reversed phase liquid chromatography mass spectrometry.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Decoding diastereomeric and impurity profiles of phosphorothioated siRNAs via 2D anion-exchange chromatography coupled with ion-pair reversed phase liquid chromatography mass spectrometry.
1955,4643,40825746,10.1021/acs.analchem.5c03045,chemistry,siRNA,PubMed abstract sentence 1,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Beyond Liquid Chromatography: Cyclic Ion Mobility Spectrometry for Phosphorothioate Diastereomer Separation in siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Beyond Liquid Chromatography: Cyclic Ion Mobility Spectrometry for Phosphorothioate Diastereomer Separation in siRNA.
1959,4651,40720013,10.1007/978-1-0716-4730-1_6,benchmark,ASO,PubMed abstract sentence 2,model;prediction;tool,"benchmark candidate; matched derived terms: model, prediction, tool; source title: In Silico Prediction and Selection of Exon-Skipping Antisense Oligonucleotide Sequences Using eSkip-Finder.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Silico Prediction and Selection of Exon-Skipping Antisense Oligonucleotide Sequences Using eSkip-Finder.
1962,4658,40554999,10.1016/j.bbrc.2025.152226,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Hyaluronic acid-functionalized PLGA nanoparticles loaded with circSNX6 siRNA overcome sunitinib resistance in renal cell carcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hyaluronic acid-functionalized PLGA nanoparticles loaded with circSNX6 siRNA overcome sunitinib resistance in renal cell carcinoma.
1969,4673,39082226,10.1002/anie.202407398,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Development of Organ Targeting Lipid Nanoparticles with Low Immunogenicity and Their Application in the Treatment of Pulmonary Fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of Organ Targeting Lipid Nanoparticles with Low Immunogenicity and Their Application in the Treatment of Pulmonary Fibrosis.
1971,4677,38762666,10.1007/s00204-024-03755-w,assay,ASO/siRNA,PubMed abstract sentence 10,screen;model,"assay candidate; matched derived terms: screen, model; source title: A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats."
1972,4678,38762666,10.1007/s00204-024-03755-w,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats."
1973,4679,38762666,10.1007/s00204-024-03755-w,benchmark,ASO/siRNA,PubMed abstract sentence 10,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A novel support vector machine-based 1-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats."
1986,4710,35500062,10.1021/acsnano.1c08508,delivery,ASO,PubMed abstract sentence 5,delivery;galnac;conjugated,"delivery candidate; matched derived terms: delivery, galnac, conjugated; source title: Cholesterol-Mediated Seeding of Protein Corona on DNA Nanostructures for Targeted Delivery of Oligonucleotide Therapeutics to Treat Liver Fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cholesterol-Mediated Seeding of Protein Corona on DNA Nanostructures for Targeted Delivery of Oligonucleotide Therapeutics to Treat Liver Fibrosis.
1998,4738,32356888,10.1093/nar/gkaa299,chemistry,ASO,PubMed abstract sentence 2,chemical;modification;modified;phosphorothioate,"chemistry candidate; matched derived terms: chemical, modification, modified, phosphorothioate; source title: Phosphorothioate modified oligonucleotide-protein interactions.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phosphorothioate modified oligonucleotide-protein interactions.
1999,4741,31863718,10.1002/cbic.201900631,chemistry,ASO,PubMed abstract sentence 2,chemical;modification;phosphorothioate,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate; source title: Identification of a Tricyclic P(III) Chiral Auxiliary for Solid-Supported Synthesis of Stereopure Phosphorothioate-Containing Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of a Tricyclic P(III) Chiral Auxiliary for Solid-Supported Synthesis of Stereopure Phosphorothioate-Containing Oligonucleotides.
2001,4745,31829247,10.1186/s13075-019-2044-2,toxicity,ASO/siRNA,PubMed abstract sentence 12,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: LNA-anti-miR-150 ameliorated kidney injury of lupus nephritis by inhibiting renal fibrosis and macrophage infiltration.",B,high_candidate,curator_rejected,reject,derived_annotations_only,LNA-anti-miR-150 ameliorated kidney injury of lupus nephritis by inhibiting renal fibrosis and macrophage infiltration.
2004,4754,27074387,10.1021/acs.bioconjchem.6b00107,chemistry,ASO,PubMed abstract sentence 1,phosphorothioate;conjugate,"chemistry candidate; matched derived terms: phosphorothioate, conjugate; source title: Optimization, Production, and Characterization of a CpG-Oligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Optimization, Production, and Characterization of a CpG-Oligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen."
2008,4762,25712094,10.1093/nar/gkv143,chemistry,ASO,PubMed abstract sentence 1,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages.
2011,4771,22454061,10.1007/978-1-61779-767-5_11,chemistry,ASO/siRNA,PubMed abstract sentence 2,modified;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: modified, phosphorothioate, 2'-o; source title: Optimizing splice-switching oligomer sequences using 2'-O-methyl phosphorothioate chemistry.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimizing splice-switching oligomer sequences using 2'-O-methyl phosphorothioate chemistry.
2012,4774,21423181,10.1038/ng.786,chemistry,ASO/siRNA,PubMed abstract sentence 5,lna;conjugate,"chemistry candidate; matched derived terms: lna, conjugate; source title: Silencing of microRNA families by seed-targeting tiny LNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing of microRNA families by seed-targeting tiny LNAs.
2015,4781,42182284,10.64898/2026.05.09.723998,assay,ASO/siRNA,PubMed abstract sentence 12,screen;experiment,"assay candidate; matched derived terms: screen, experiment; source title: A multi-species toolkit of TOP2 hypercleavage mutants for studying topoisomerase II-mediated DNA damage.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A multi-species toolkit of TOP2 hypercleavage mutants for studying topoisomerase II-mediated DNA damage.
2016,4782,42182284,10.64898/2026.05.09.723998,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic;dna damage,"toxicity candidate; matched derived terms: toxicity, toxic, dna damage; source title: A multi-species toolkit of TOP2 hypercleavage mutants for studying topoisomerase II-mediated DNA damage.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A multi-species toolkit of TOP2 hypercleavage mutants for studying topoisomerase II-mediated DNA damage.
2024,4800,42076080,10.3390/pharmaceutics18040428,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: pH-Responsive Nanostructured Calcium Phosphate Microrods as Pulmonary Delivery Platform: Fabrication, Characterization, and Comparative Assessment of Cytotoxic and Transcriptomic Responses in Alveolar Macrophages.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"pH-Responsive Nanostructured Calcium Phosphate Microrods as Pulmonary Delivery Platform: Fabrication, Characterization, and Comparative Assessment of Cytotoxic and Transcriptomic Responses in Alveolar Macrophages."
2034,4822,41948127,10.1016/j.omtn.2026.102881,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Safety, efficacy, and distal nerve Schwann cell biodistribution in mice and NHPs to support translation of AAV9 RNAi therapy for CMT1A.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Safety, efficacy, and distal nerve Schwann cell biodistribution in mice and NHPs to support translation of AAV9 RNAi therapy for CMT1A."
2043,4847,41839265,10.1016/j.jconrel.2026.114825,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Impact of ionizable lipid source on quality and stability of siRNA-loaded lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Impact of ionizable lipid source on quality and stability of siRNA-loaded lipid nanoparticles.
2050,4864,41772923,10.1002/pds.70342,toxicity,ASO/siRNA,PubMed abstract sentence 16,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Safety of Short-Term Trimethoprim-Sulfamethoxazole Use for Uncomplicated Cystitis: A Nationwide Retrospective Cohort Study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety of Short-Term Trimethoprim-Sulfamethoxazole Use for Uncomplicated Cystitis: A Nationwide Retrospective Cohort Study.
2051,4867,41764319,10.1038/s41598-026-41197-9,assay,ASO,PubMed abstract sentence 5,screen;model,"assay candidate; matched derived terms: screen, model; source title: A xenotransplantation model for reactivation of paternal UBE3A using human-specific antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A xenotransplantation model for reactivation of paternal UBE3A using human-specific antisense oligonucleotides.
2055,4877,41719142,10.1021/jacs.5c23209,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Structure-Activity-Driven Multicompartment Lipid Nanoparticles for Synergistic mRNA and siRNA Codelivery in Acute Myeloid Leukemia.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structure-Activity-Driven Multicompartment Lipid Nanoparticles for Synergistic mRNA and siRNA Codelivery in Acute Myeloid Leukemia.
2058,4884,41709402,10.1002/adhm.202505340,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;lnp;route,"delivery candidate; matched derived terms: delivery, lnp, route; source title: Novel Lipid Nanoparticle (LNP) Delivery Systems Enabling the Advancement of RNA Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel Lipid Nanoparticle (LNP) Delivery Systems Enabling the Advancement of RNA Therapeutics.
2069,4905,41510588,10.1002/adma.202519473,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Optimized Lipid Nanoparticles for Co-Delivery of mRNA and siRNA Therapeutics in Refractory Liver Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimized Lipid Nanoparticles for Co-Delivery of mRNA and siRNA Therapeutics in Refractory Liver Cancer.
2073,4915,41453683,10.1016/j.virusres.2025.199682,delivery,ASO,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Optimization of lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes for in vivo delivery of a CRISPR/Cas9 system targeting hepatitis B virus.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimization of lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes for in vivo delivery of a CRISPR/Cas9 system targeting hepatitis B virus.
2075,4919,41424036,10.1093/dnares/dsaf038,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Whole genome analysis of toxic Papilionidae butterflies utilizing aristolochic acid, Pachliopta aristolochiae, and Byasa alcinous.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Whole genome analysis of toxic Papilionidae butterflies utilizing aristolochic acid, Pachliopta aristolochiae, and Byasa alcinous."
2076,4922,41405194,10.1111/jdi.70193,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Evaluation of the effectiveness and safety of ONO-2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo-controlled, double-blind study in Japanese patients.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Evaluation of the effectiveness and safety of ONO-2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo-controlled, double-blind study in Japanese patients."
2078,4926,41354630,10.1002/advs.202517617,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Genome-Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle-Mediated siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Genome-Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle-Mediated siRNA Delivery.
2082,4936,41335047,10.1177/21593337251391564,assay,ASO,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Antisense Oligonucleotide Quantification via Splint-Ligation PCR Assay in Nonhuman Primate Central Nervous System Tissues and Biofluids.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense Oligonucleotide Quantification via Splint-Ligation PCR Assay in Nonhuman Primate Central Nervous System Tissues and Biofluids.
2088,4950,41274361,10.1016/j.ejps.2025.107386,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Pulmonary delivery of siRNA lipoplexes and lipid nanoparticles using a vibrating mesh nebuliser.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pulmonary delivery of siRNA lipoplexes and lipid nanoparticles using a vibrating mesh nebuliser.
2095,4967,41504091,10.31083/FBE44344,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Targeting the LRRK2 G2019S Mutation Found in Parkinson's Disease: Efficiency of Biosynthesized Solid Lipid Nanoparticles for Therapeutic siRNA-Mediated Gene Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting the LRRK2 G2019S Mutation Found in Parkinson's Disease: Efficiency of Biosynthesized Solid Lipid Nanoparticles for Therapeutic siRNA-Mediated Gene Therapy.
2096,4970,41503997,10.31083/JIN45212,chemistry,siRNA,PubMed abstract sentence 2,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Dual-Modified Mannose/RVG29 Peptide-Functionalized Lipid Nanoparticles Loaded With circHIPK2 siRNA Ameliorate Hypoxic-Ischemic Brain Damage in Neonatal Mice by Suppressing Astrocyte Activation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dual-Modified Mannose/RVG29 Peptide-Functionalized Lipid Nanoparticles Loaded With circHIPK2 siRNA Ameliorate Hypoxic-Ischemic Brain Damage in Neonatal Mice by Suppressing Astrocyte Activation.
2097,4971,41503997,10.31083/JIN45212,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Dual-Modified Mannose/RVG29 Peptide-Functionalized Lipid Nanoparticles Loaded With circHIPK2 siRNA Ameliorate Hypoxic-Ischemic Brain Damage in Neonatal Mice by Suppressing Astrocyte Activation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dual-Modified Mannose/RVG29 Peptide-Functionalized Lipid Nanoparticles Loaded With circHIPK2 siRNA Ameliorate Hypoxic-Ischemic Brain Damage in Neonatal Mice by Suppressing Astrocyte Activation.
2105,4991,41256914,10.1016/j.ijpx.2025.100428,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Engineered extracellular vesicles demonstrate altered endocytosis and biodistribution and have superior oral siRNA delivery efficiency compared to lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered extracellular vesicles demonstrate altered endocytosis and biodistribution and have superior oral siRNA delivery efficiency compared to lipid nanoparticles.
2106,4992,41256914,10.1016/j.ijpx.2025.100428,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineered extracellular vesicles demonstrate altered endocytosis and biodistribution and have superior oral siRNA delivery efficiency compared to lipid nanoparticles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Engineered extracellular vesicles demonstrate altered endocytosis and biodistribution and have superior oral siRNA delivery efficiency compared to lipid nanoparticles.
2107,4995,41244463,10.1021/acsomega.5c05346,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Aminoglycoside Drugs as Adjuvants to Enhance siRNA/mRNA Delivery by Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aminoglycoside Drugs as Adjuvants to Enhance siRNA/mRNA Delivery by Lipid Nanoparticles.
2110,5000,41220634,10.1039/d5ra05904f,delivery,ASO,PubMed abstract sentence 3,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Enhancing the intracellular delivery of antisense oligonucleotides (ASO) : a comparative study of aptamer, vitamin E, and cholesterol ASO conjugates.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Enhancing the intracellular delivery of antisense oligonucleotides (ASO) : a comparative study of aptamer, vitamin E, and cholesterol ASO conjugates."
2112,5002,41220634,10.1039/d5ra05904f,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhancing the intracellular delivery of antisense oligonucleotides (ASO) : a comparative study of aptamer, vitamin E, and cholesterol ASO conjugates.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Enhancing the intracellular delivery of antisense oligonucleotides (ASO) : a comparative study of aptamer, vitamin E, and cholesterol ASO conjugates."
2114,5008,41155935,10.3390/pharmaceutics17101298,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Targeted Delivery of VEGF-siRNA to Glioblastoma Using Orientation-Controlled Anti-PD-L1 Antibody-Modified Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted Delivery of VEGF-siRNA to Glioblastoma Using Orientation-Controlled Anti-PD-L1 Antibody-Modified Lipid Nanoparticles.
2120,5022,41100926,10.1016/j.dmd.2025.100167,assay,ASO,PubMed abstract sentence 6,preclinical;model;phase,"assay candidate; matched derived terms: preclinical, model, phase; source title: Multispecies minimal physiologically based pharmacokinetic-pharmacodynamic model of antisense oligonucleotides for central nervous system disorders.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multispecies minimal physiologically based pharmacokinetic-pharmacodynamic model of antisense oligonucleotides for central nervous system disorders.
2122,5026,41083040,10.1016/j.actbio.2025.10.018,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Tuning the polyethylene glycol-lipid anchor length of lipid nanoparticles to enhance brain-targeted siRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tuning the polyethylene glycol-lipid anchor length of lipid nanoparticles to enhance brain-targeted siRNA delivery.
2124,5030,41080724,10.1016/j.mtbio.2025.102357,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid nanoparticle-mediated mRNA/siRNA dual-bioengineered dendritic cell vaccines combined of PD-1/PD-L1 blockade for boosting tumor immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle-mediated mRNA/siRNA dual-bioengineered dendritic cell vaccines combined of PD-1/PD-L1 blockade for boosting tumor immunotherapy.
2129,5043,41020503,10.1093/nar/gkaf937,offtarget,ASO/siRNA,PubMed abstract sentence 4,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs.
2131,5047,41005745,10.1016/j.jconrel.2025.114251,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhanced safety and potency in local angiogenic growth factor delivery via aptamer functionalization of hydrogels.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhanced safety and potency in local angiogenic growth factor delivery via aptamer functionalization of hydrogels.
2132,5050,40998813,10.1038/s41467-025-63651-4,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Buffer optimization of siRNA-lipid nanoparticles mitigates lipid oxidation and RNA-lipid adduct formation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Buffer optimization of siRNA-lipid nanoparticles mitigates lipid oxidation and RNA-lipid adduct formation.
2133,5053,40967321,10.1016/j.ijpharm.2025.126186,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Deciphering the role of polyethylene glycol-lipid anchors in siRNA-LNP efficacy for P2y2 inhibition in bone marrow-derived macrophages.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Deciphering the role of polyethylene glycol-lipid anchors in siRNA-LNP efficacy for P2y2 inhibition in bone marrow-derived macrophages.
2134,5056,40965558,10.1007/s13346-025-01970-1,delivery,ASO/siRNA,PubMed abstract sentence 8,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Precision engineering of macrophage reprogramming with RNA interference-loaded lipid nanoparticles: a game-changer in cancer immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Precision engineering of macrophage reprogramming with RNA interference-loaded lipid nanoparticles: a game-changer in cancer immunotherapy.
2135,5059,40962081,10.1016/j.ijpharm.2025.126183,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Development of BMX siRNA lipid nanoparticles using novel ionizable and cleavable lipids discovered through AI and experimentation for cancer therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of BMX siRNA lipid nanoparticles using novel ionizable and cleavable lipids discovered through AI and experimentation for cancer therapy.
2136,5062,40946350,10.1016/j.cis.2025.103665,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Advances in aptasensors engineered with carbon nanomaterials for food safety monitoring.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in aptasensors engineered with carbon nanomaterials for food safety monitoring.
2137,5065,40912499,10.1016/j.fct.2025.115723,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exploring the toxicological network of bleomycin-induced pulmonary fibrosis: The role of long non-coding RNAs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exploring the toxicological network of bleomycin-induced pulmonary fibrosis: The role of long non-coding RNAs.
2138,5068,40893381,10.1016/j.mtbio.2025.102205,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Self-assembled extracellular matrix-lipid nanoparticle composite for site-specific siRNA delivery to improve cardiac repair post-myocardial infarction.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Self-assembled extracellular matrix-lipid nanoparticle composite for site-specific siRNA delivery to improve cardiac repair post-myocardial infarction.
2141,5075,40862077,10.1021/acsnanoscienceau.4c00066,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer.
2142,5076,40862077,10.1021/acsnanoscienceau.4c00066,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer.
2146,5084,40841123,10.1136/openhrt-2025-003490,toxicity,ASO/siRNA,PubMed abstract sentence 3,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: PCSK9 targeting therapies for familial hypercholesterolaemia: a meta-analysis of efficacy on lipid biomarkers and safety in adults and children across 23 RCTs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PCSK9 targeting therapies for familial hypercholesterolaemia: a meta-analysis of efficacy on lipid biomarkers and safety in adults and children across 23 RCTs.
2147,5089,40819710,10.1016/j.ijpharm.2025.126084,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Evaluation of rayleigh jet atomizer for intranasal delivery of lipid nanoparticle-siRNA formulations: stability, deposition, and device performance.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Evaluation of rayleigh jet atomizer for intranasal delivery of lipid nanoparticle-siRNA formulations: stability, deposition, and device performance."
2149,5093,40818473,10.1016/S1474-4422(25)00225-X,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Safety and efficacy of apitegromab in nonambulatory type 2 or type 3 spinal muscular atrophy (SAPPHIRE): a phase 3, double-blind, randomised, placebo-controlled trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Safety and efficacy of apitegromab in nonambulatory type 2 or type 3 spinal muscular atrophy (SAPPHIRE): a phase 3, double-blind, randomised, placebo-controlled trial."
2150,5094,40818473,10.1016/S1474-4422(25)00225-X,toxicity,ASO/siRNA,PubMed abstract sentence 10,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Safety and efficacy of apitegromab in nonambulatory type 2 or type 3 spinal muscular atrophy (SAPPHIRE): a phase 3, double-blind, randomised, placebo-controlled trial.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Safety and efficacy of apitegromab in nonambulatory type 2 or type 3 spinal muscular atrophy (SAPPHIRE): a phase 3, double-blind, randomised, placebo-controlled trial."
2152,5104,40727077,10.1016/j.mtbio.2025.102075,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: FMRP silencing via siRNA lipid nanoparticles to reprogram the tumor microenvironment and enhance anti-PD-1 efficacy in triple-negative breast cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,FMRP silencing via siRNA lipid nanoparticles to reprogram the tumor microenvironment and enhance anti-PD-1 efficacy in triple-negative breast cancer.
2154,5110,40717437,10.1021/acs.molpharmaceut.5c00272,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: SOX9 siRNA Loaded Lipid Nanoparticles Actively Targeted: Formulation, Delivery, and Antitumor Effect on Colorectal Cancer In Vitro and In Vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"SOX9 siRNA Loaded Lipid Nanoparticles Actively Targeted: Formulation, Delivery, and Antitumor Effect on Colorectal Cancer In Vitro and In Vivo."
2157,5115,40713179,10.1136/jitc-2025-011651,toxicity,ASO/siRNA,PubMed abstract sentence 11,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Phase 1b/2 study evaluating safety, efficacy and immune effects of TLR9 agonist cavrotolimod with anti-PD-1 antibodies among patients with advanced solid tumors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Phase 1b/2 study evaluating safety, efficacy and immune effects of TLR9 agonist cavrotolimod with anti-PD-1 antibodies among patients with advanced solid tumors."
2159,5123,40652242,10.1186/s12933-025-02840-3,toxicity,ASO/siRNA,PubMed abstract sentence 1,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Glucagon-like peptide-1 receptor agonist in myocardial infarction and atherosclerotic cardiovascular disease risk reduction: a comprehensive meta-analysis of number needed to treat, efficacy and safety.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Glucagon-like peptide-1 receptor agonist in myocardial infarction and atherosclerotic cardiovascular disease risk reduction: a comprehensive meta-analysis of number needed to treat, efficacy and safety."
2160,5126,40644303,10.1021/acsbiomaterials.5c00463,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Structure-Activity Relationship of Ionizable Lipids for siRNA and mRNA Lipid Nanoparticle Design.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structure-Activity Relationship of Ionizable Lipids for siRNA and mRNA Lipid Nanoparticle Design.
2164,5136,40604820,10.1186/s12951-025-03529-1,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ultrasmall nanoparticles for co-delivery of antisense oligonucleotides targeting miR-21 and miR-210 to treat glioblastoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Ultrasmall nanoparticles for co-delivery of antisense oligonucleotides targeting miR-21 and miR-210 to treat glioblastoma.
2165,5139,40574039,10.3390/pharmaceutics17060726,assay,ASO/siRNA,PubMed abstract sentence 9,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington's Disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington's Disease.
2166,5140,40574039,10.3390/pharmaceutics17060726,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington's Disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington's Disease.
2169,5145,40571267,10.1016/j.ejps.2025.107182,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: The impact of lipid compositions on siRNA and mRNA lipid nanoparticle performance for pulmonary delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The impact of lipid compositions on siRNA and mRNA lipid nanoparticle performance for pulmonary delivery.
2171,5149,40562235,10.1016/j.jconrel.2025.113967,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Transdermal hyaluronate/cationic solid lipid nanoparticle/siRNA complex for the treatment of skin cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transdermal hyaluronate/cationic solid lipid nanoparticle/siRNA complex for the treatment of skin cancer.
2175,5161,40543790,10.1016/j.ijbiomac.2025.145398,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cinnamate 4-hydroxylase (MsC4H) mediates the biosynthesis of autotoxic substance scopoletin in alfalfa (Medicago sativa).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cinnamate 4-hydroxylase (MsC4H) mediates the biosynthesis of autotoxic substance scopoletin in alfalfa (Medicago sativa).
2177,5167,40522062,10.1111/ene.70175,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;safety;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, safety, hepatotoxicity; source title: Safety and Effectiveness of PCSK9 Inhibitors and Inclisiran in Patients With Neuromuscular Disorders and Statin Intolerance.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety and Effectiveness of PCSK9 Inhibitors and Inclisiran in Patients With Neuromuscular Disorders and Statin Intolerance.
2178,5170,40520362,10.1016/j.omtn.2025.102573,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: A4GALT-targeting siRNA lipid nanoparticles ameliorate Fabry disease phenotype: Greater efficacy in endothelial cells than in podocytes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A4GALT-targeting siRNA lipid nanoparticles ameliorate Fabry disease phenotype: Greater efficacy in endothelial cells than in podocytes.
2179,5173,40487122,10.1016/j.ajps.2024.101011,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Endosomal disruption by co-encapsulating gentamicin in lipid nanoparticles for efficient siRNA delivery and cancer therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Endosomal disruption by co-encapsulating gentamicin in lipid nanoparticles for efficient siRNA delivery and cancer therapy.
2181,5179,40472248,10.1021/acs.bioconjchem.5c00079,delivery,siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: 4'-C-Cholesterol/Pyridyl-2'-O-Methyl Uridine-Functionalized siRNA Enhances Stability and Carrier-Free Gene Silencing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,4'-C-Cholesterol/Pyridyl-2'-O-Methyl Uridine-Functionalized siRNA Enhances Stability and Carrier-Free Gene Silencing.
2186,5190,40383157,10.1016/j.jconrel.2025.113857,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: A combinatorial siRNA and mRNA approach for obesity treatment using targeting lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A combinatorial siRNA and mRNA approach for obesity treatment using targeting lipid nanoparticles.
2187,5193,40365289,10.7150/thno.112247,assay,ASO/siRNA,PubMed abstract sentence 5,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Nuclear damage-induced DNA damage response coupled with IFI16-driven ECM remodeling underlies dilated cardiomyopathy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nuclear damage-induced DNA damage response coupled with IFI16-driven ECM remodeling underlies dilated cardiomyopathy.
2188,5194,40365289,10.7150/thno.112247,toxicity,ASO/siRNA,PubMed abstract sentence 2,adverse;dna damage,"toxicity candidate; matched derived terms: adverse, dna damage; source title: Nuclear damage-induced DNA damage response coupled with IFI16-driven ECM remodeling underlies dilated cardiomyopathy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nuclear damage-induced DNA damage response coupled with IFI16-driven ECM remodeling underlies dilated cardiomyopathy.
2189,5195,40365289,10.7150/thno.112247,benchmark,ASO/siRNA,PubMed abstract sentence 5,model;dataset,"benchmark candidate; matched derived terms: model, dataset; source title: Nuclear damage-induced DNA damage response coupled with IFI16-driven ECM remodeling underlies dilated cardiomyopathy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nuclear damage-induced DNA damage response coupled with IFI16-driven ECM remodeling underlies dilated cardiomyopathy.
2190,5198,40316188,10.1016/j.ijpharm.2025.125666,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Targeted delivery of circPDHK1 siRNA via aptamer functionalized lipid nanoparticles inhibits ccRCC growth and migration.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted delivery of circPDHK1 siRNA via aptamer functionalized lipid nanoparticles inhibits ccRCC growth and migration.
2192,5202,40313059,10.1039/d5an00233h,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanochannel array-based platform for aggregation monitoring and high-sensitive identification of neurotoxic amyloid-β oligomers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanochannel array-based platform for aggregation monitoring and high-sensitive identification of neurotoxic amyloid-β oligomers.
2195,5209,40278802,10.1002/advs.202417363,delivery,ASO,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Magnetic-Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Magnetic-Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models.
2198,5212,40278802,10.1002/advs.202417363,benchmark,ASO,PubMed abstract sentence 1,model;challenge,"benchmark candidate; matched derived terms: model, challenge; source title: Magnetic-Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Magnetic-Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models.
2205,5229,40248028,10.2147/IJN.S504639,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Using siRNA-Based Anti-Inflammatory Lipid Nanoparticles for Gene Regulation in Psoriasis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Using siRNA-Based Anti-Inflammatory Lipid Nanoparticles for Gene Regulation in Psoriasis.
2208,5236,40214727,10.1007/s00210-025-04135-6,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Anti-miRNA- 155 - 5p enhances the cytotoxic efficacy of temozolomide in brain cancer stem cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Anti-miRNA- 155 - 5p enhances the cytotoxic efficacy of temozolomide in brain cancer stem cells.
2210,5242,40166479,10.3762/bjnano.16.34,delivery,ASO,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment.
2211,5243,40166479,10.3762/bjnano.16.34,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment.
2212,5246,40120691,10.1016/j.jconrel.2025.113622,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: ATP-responsive tumor targeted lipid nanoparticle for enhanced siRNA delivery and improved treatment efficacy in melanoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,ATP-responsive tumor targeted lipid nanoparticle for enhanced siRNA delivery and improved treatment efficacy in melanoma.
2215,5251,40120068,10.1002/cncr.35820,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: INO-CD22: A multicenter, real-world study of inotuzumab ozogamicin safety and effectiveness in adult patients with relapsed/refractory acute lymphoblastic leukemia.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"INO-CD22: A multicenter, real-world study of inotuzumab ozogamicin safety and effectiveness in adult patients with relapsed/refractory acute lymphoblastic leukemia."
2216,5254,40115963,10.1016/j.ijpx.2025.100324,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice.
2217,5257,40093884,10.7150/thno.111685,delivery,siRNA,PubMed abstract sentence 7,nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: nanoparticle, lnp, uptake; source title: Zwitterionic lipid nanoparticles for efficient siRNA delivery and hypercholesterolemia therapy with rational charge self-transformation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Zwitterionic lipid nanoparticles for efficient siRNA delivery and hypercholesterolemia therapy with rational charge self-transformation.
2221,5263,40084594,10.1002/edm2.70039,toxicity,ASO/siRNA,PubMed abstract sentence 8,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Safety and Efficacy of Inclisiran in Hyperlipidemia: An Updated Meta-Analysis of Randomised Controlled Trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety and Efficacy of Inclisiran in Hyperlipidemia: An Updated Meta-Analysis of Randomised Controlled Trials.
2226,5274,40068204,10.1021/jacs.4c18308,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles.
2230,5284,40015385,10.1016/j.biotechadv.2025.108546,delivery,siRNA,PubMed abstract sentence 7,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors.
2231,5285,40015385,10.1016/j.biotechadv.2025.108546,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors.
2232,5288,40015110,10.1016/j.bioorg.2025.108299,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;galnac;lna,"chemistry candidate; matched derived terms: chemical, galnac, lna; source title: On the interaction of anticancer G-quadruplex ligands with GalNAc-functionalized G-quadruplex-forming carriers for selective recognition and treatment of hepatocellular carcinoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,On the interaction of anticancer G-quadruplex ligands with GalNAc-functionalized G-quadruplex-forming carriers for selective recognition and treatment of hepatocellular carcinoma.
2233,5289,40015110,10.1016/j.bioorg.2025.108299,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: On the interaction of anticancer G-quadruplex ligands with GalNAc-functionalized G-quadruplex-forming carriers for selective recognition and treatment of hepatocellular carcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,On the interaction of anticancer G-quadruplex ligands with GalNAc-functionalized G-quadruplex-forming carriers for selective recognition and treatment of hepatocellular carcinoma.
2234,5292,40006524,10.3390/pharmaceutics17020157,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge.
2235,5293,40006524,10.3390/pharmaceutics17020157,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge.
2236,5296,40000558,10.1007/s13346-025-01815-x,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Preclinical testing of antiviral siRNA therapeutics delivered in lipid nanoparticles in animal models - a comprehensive review.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical testing of antiviral siRNA therapeutics delivered in lipid nanoparticles in animal models - a comprehensive review.
2237,5297,40000558,10.1007/s13346-025-01815-x,assay,siRNA,PubMed abstract sentence 6,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Preclinical testing of antiviral siRNA therapeutics delivered in lipid nanoparticles in animal models - a comprehensive review.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical testing of antiviral siRNA therapeutics delivered in lipid nanoparticles in animal models - a comprehensive review.
2241,5305,39990935,10.1021/acsbiomedchemau.4c00085,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Exploring the Effects of Incorporating Different Bioactive Phospholipids into Messenger Ribonucleic Acid Lipid Nanoparticle (mRNA LNP) Formulations.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exploring the Effects of Incorporating Different Bioactive Phospholipids into Messenger Ribonucleic Acid Lipid Nanoparticle (mRNA LNP) Formulations.
2244,5312,39896578,10.1101/2025.01.23.633455,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticle delivery of siRNA to dorsal root ganglion neurons to treat pain.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle delivery of siRNA to dorsal root ganglion neurons to treat pain.
2247,5323,39692702,10.1111/jocd.16722,assay,siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: A Novel Injectable Polypeptide Nanoparticle Encapsulated siRNA Targeting TGF-β1 and COX-2 for Localized Fat Reduction II: Phase I Clinical Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Novel Injectable Polypeptide Nanoparticle Encapsulated siRNA Targeting TGF-β1 and COX-2 for Localized Fat Reduction II: Phase I Clinical Trial.
2248,5326,39678704,10.1016/j.lanepe.2024.101136,assay,ASO/siRNA,PubMed abstract sentence 5,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Efficacy and safety of SQ house dust mite sublingual immunotherapy-tablet (12 SQ-HDM) in children with allergic rhinitis/rhinoconjunctivitis with or without asthma (MT-12): a randomised, double-blind, placebo-controlled, phase III trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Efficacy and safety of SQ house dust mite sublingual immunotherapy-tablet (12 SQ-HDM) in children with allergic rhinitis/rhinoconjunctivitis with or without asthma (MT-12): a randomised, double-blind, placebo-controlled, phase III trial."
2251,5333,39642315,10.1182/bloodadvances.2024013900,toxicity,ASO/siRNA,PubMed abstract sentence 6,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Long-term safety and efficacy of fitusiran prophylaxis, and perioperative management, in people with hemophilia A or B.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Long-term safety and efficacy of fitusiran prophylaxis, and perioperative management, in people with hemophilia A or B."
2253,5337,39488022,10.1016/j.jcis.2024.10.115,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid nanoparticles as nano-Trojan-horses for siRNA delivery and gene-knockdown.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Lipid nanoparticles as nano-Trojan-horses for siRNA delivery and gene-knockdown.
2259,5355,38860908,10.2174/0109298673300236240529195835,chemistry,ASO,PubMed abstract sentence 7,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Medicinal Chemistry of Antisense Oligonucleotides for Therapeutic Use in SARS-CoV-2: Design Strategies and Challenges for Targeted Delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Medicinal Chemistry of Antisense Oligonucleotides for Therapeutic Use in SARS-CoV-2: Design Strategies and Challenges for Targeted Delivery.
2263,5365,39645294,10.1016/j.arteri.2024.07.003,toxicity,ASO/siRNA,PubMed abstract sentence 2,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Efficacy, benefit and safety of inclisiran.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Efficacy, benefit and safety of inclisiran."
2267,5373,39578347,10.1007/s13555-024-01301-1,toxicity,ASO/siRNA,PubMed abstract sentence 6,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: A Multicenter Randomized Double-Blind Vehicle-Controlled Parallel Group Phase 2 Study Evaluating the Efficacy and Safety of GN-037 Cream in Patients with Mild-to-Moderate Plaque Psoriasis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Multicenter Randomized Double-Blind Vehicle-Controlled Parallel Group Phase 2 Study Evaluating the Efficacy and Safety of GN-037 Cream in Patients with Mild-to-Moderate Plaque Psoriasis.
2269,5379,39521985,10.1186/s12872-024-04321-z,toxicity,ASO/siRNA,PubMed abstract sentence 8,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Efficacy and safety of inclisiran versus PCSK9 inhibitor versus statin plus ezetimibe therapy in hyperlipidemia: a systematic review and network meta-analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and safety of inclisiran versus PCSK9 inhibitor versus statin plus ezetimibe therapy in hyperlipidemia: a systematic review and network meta-analysis.
2271,5383,39504879,10.1016/j.ecoenv.2024.117282,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: piRNA array analysis provide insight into the mechanism of DEHP-induced testicular toxicology in pubertal male rats.",B,high_candidate,curator_rejected,reject,derived_annotations_only,piRNA array analysis provide insight into the mechanism of DEHP-induced testicular toxicology in pubertal male rats.
2273,5393,39359895,10.1293/tox.2024-0048,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Natural outbreak of Mycobacterium caprae infection in imported laboratory cynomolgus macaques (Macaca fascicularis): diagnostic pitfalls and management of safety precautions.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Natural outbreak of Mycobacterium caprae infection in imported laboratory cynomolgus macaques (Macaca fascicularis): diagnostic pitfalls and management of safety precautions.
2283,5423,39106320,10.1126/scisignal.adl1030,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Poly-GR repeats associated with ALS/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Poly-GR repeats associated with ALS/FTD gene C9ORF72 impair translation elongation and induce a ribotoxic stress response in neurons.
2290,5440,39046946,10.1089/nat.2024.0002,chemistry,ASO,PubMed abstract sentence 3,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Levels of Exon-Skipping Are Not Artificially Overestimated Because of the Increased Affinity of Tricyclo-DNA-Modified Antisense Oligonucleotides to the Target DMD Exon.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Levels of Exon-Skipping Are Not Artificially Overestimated Because of the Increased Affinity of Tricyclo-DNA-Modified Antisense Oligonucleotides to the Target DMD Exon.
2295,5455,38973655,10.1002/adma.202313791,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Expanding RNAi to Kidneys, Lungs, and Spleen via Selective ORgan Targeting (SORT) siRNA Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Expanding RNAi to Kidneys, Lungs, and Spleen via Selective ORgan Targeting (SORT) siRNA Lipid Nanoparticles."
2302,5470,38923700,10.1002/smll.202400643,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: In Vivo Endothelial Cell Gene Silencing by siRNA-LNPs Tuned with Lipoamino Bundle Chemical and Ligand Targeting.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vivo Endothelial Cell Gene Silencing by siRNA-LNPs Tuned with Lipoamino Bundle Chemical and Ligand Targeting.
2309,5491,38779336,10.1016/j.omtm.2024.101258,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles.
2311,5495,38772620,10.1111/resp.14753,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic;adverse;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, adverse, hepatotoxicity; source title: Safety of pyrazinamide in elderly patients with tuberculosis in Japan: A nationwide cohort study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety of pyrazinamide in elderly patients with tuberculosis in Japan: A nationwide cohort study.
2312,5500,38770138,10.1016/j.isci.2024.109804,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery in vivo.
2321,5527,38573183,10.2217/fon-2023-0872,assay,ASO,PubMed abstract sentence 1,preclinical;phase,"assay candidate; matched derived terms: preclinical, phase; source title: Preclinical and phase I studies of an antisense oligonucleotide drug targeting IGF-1R in liver cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical and phase I studies of an antisense oligonucleotide drug targeting IGF-1R in liver cancer.
2322,5528,38573183,10.2217/fon-2023-0872,toxicity,ASO,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Preclinical and phase I studies of an antisense oligonucleotide drug targeting IGF-1R in liver cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preclinical and phase I studies of an antisense oligonucleotide drug targeting IGF-1R in liver cancer.
2323,5531,38520331,10.1002/ps.8098,toxicity,siRNA,PubMed abstract sentence 4,safety;risk;adverse,"toxicity candidate; matched derived terms: safety, risk, adverse; source title: Biosafety aspects of RNAi-based pests control.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Biosafety aspects of RNAi-based pests control.
2330,5552,38381848,10.1126/scitranslmed.adh0027,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
2333,5557,38371290,10.1016/j.jacasi.2023.09.006,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Efficacy and Safety of Inclisiran in Asian Patients: Results From ORION-18.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficacy and Safety of Inclisiran in Asian Patients: Results From ORION-18.
2334,5558,38371290,10.1016/j.jacasi.2023.09.006,toxicity,ASO/siRNA,PubMed abstract sentence 3,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Efficacy and Safety of Inclisiran in Asian Patients: Results From ORION-18.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficacy and Safety of Inclisiran in Asian Patients: Results From ORION-18.
2335,5561,38363779,10.1371/journal.pone.0298815,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Evaluation of the anti-cancer efficacy of lipid nanoparticles containing siRNA against HPV16 E6/E7 combined with cisplatin in a xenograft model of cervical cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of the anti-cancer efficacy of lipid nanoparticles containing siRNA against HPV16 E6/E7 combined with cisplatin in a xenograft model of cervical cancer.
2341,5571,38357922,10.1172/JCI169562,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy.
2347,5583,38312239,10.1016/j.eclinm.2024.102425,assay,ASO/siRNA,PubMed abstract sentence 4,screen;trial,"assay candidate; matched derived terms: screen, trial; source title: Safety and efficacy of sequential treatments for postmenopausal osteoporosis: a network meta-analysis of randomised controlled trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Safety and efficacy of sequential treatments for postmenopausal osteoporosis: a network meta-analysis of randomised controlled trials.
2348,5584,38312239,10.1016/j.eclinm.2024.102425,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Safety and efficacy of sequential treatments for postmenopausal osteoporosis: a network meta-analysis of randomised controlled trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety and efficacy of sequential treatments for postmenopausal osteoporosis: a network meta-analysis of randomised controlled trials.
2351,5591,38309418,10.1016/j.jlr.2024.100514,assay,ASO,PubMed abstract sentence 2,preclinical;model;experiment,"assay candidate; matched derived terms: preclinical, model, experiment; source title: Evaluation of antisense oligonucleotide therapy targeting Hsd17b13 in a fibrosis mice model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of antisense oligonucleotide therapy targeting Hsd17b13 in a fibrosis mice model.
2353,5597,38269451,10.1002/ejhf.3139,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model;phase,"assay candidate; matched derived terms: preclinical, model, phase; source title: Efficacy and safety of CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction: Rationale and design of the HF-REVERT trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficacy and safety of CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction: Rationale and design of the HF-REVERT trial.
2357,5605,38220186,10.5551/jat.64454,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Efficacy, Safety, and Pharmacokinetics of Inclisiran in Japanese Patients: Results from ORION-15.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Efficacy, Safety, and Pharmacokinetics of Inclisiran in Japanese Patients: Results from ORION-15."
2358,5606,38220186,10.5551/jat.64454,toxicity,ASO/siRNA,PubMed abstract sentence 1,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Efficacy, Safety, and Pharmacokinetics of Inclisiran in Japanese Patients: Results from ORION-15.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Efficacy, Safety, and Pharmacokinetics of Inclisiran in Japanese Patients: Results from ORION-15."
2361,5613,38214504,10.1021/acs.molpharmaceut.3c00845,delivery,ASO/siRNA,PubMed abstract sentence 13,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: In Vitro and In Vivo Evaluation of the Pathology and Safety Aspects of Three- and Four-Way Junction RNA Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vitro and In Vivo Evaluation of the Pathology and Safety Aspects of Three- and Four-Way Junction RNA Nanoparticles.
2362,5614,38214504,10.1021/acs.molpharmaceut.3c00845,toxicity,ASO/siRNA,PubMed abstract sentence 12,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: In Vitro and In Vivo Evaluation of the Pathology and Safety Aspects of Three- and Four-Way Junction RNA Nanoparticles.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In Vitro and In Vivo Evaluation of the Pathology and Safety Aspects of Three- and Four-Way Junction RNA Nanoparticles.
2367,5627,38063346,10.1080/14740338.2023.2293201,toxicity,ASO/siRNA,PubMed abstract sentence 7,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: A systematic review and meta-analysis of tolerability, cardiac safety and efficacy of inclisiran for the therapy of hyperlipidemic patients.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"A systematic review and meta-analysis of tolerability, cardiac safety and efficacy of inclisiran for the therapy of hyperlipidemic patients."
2368,5630,38060340,10.2217/fon-2023-0702,assay,ASO,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Autologous cell immunotherapy (IGV-001) with IGF-1R antisense oligonucleotide in newly diagnosed glioblastoma patients.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Autologous cell immunotherapy (IGV-001) with IGF-1R antisense oligonucleotide in newly diagnosed glioblastoma patients.
2370,5636,37649429,10.1080/00207454.2023.2251662,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Safety and effectiveness of nusinersen, a treatment for spinal muscular atrophy, in 524 patients: results from an interim analysis of post-marketing surveillance in Japan.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety and effectiveness of nusinersen, a treatment for spinal muscular atrophy, in 524 patients: results from an interim analysis of post-marketing surveillance in Japan."
2375,5649,35787224,10.1080/00207454.2022.2095270,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Real-world safety and effectiveness of nusinersen, a treatment for spinal muscular atrophy, in 401 Japanese patients: results from an interim analysis of post-marketing surveillance.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Real-world safety and effectiveness of nusinersen, a treatment for spinal muscular atrophy, in 401 Japanese patients: results from an interim analysis of post-marketing surveillance."
2376,5652,38380881,10.1177/01926233241230542,toxicity,ASO/siRNA,PubMed abstract sentence 7,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Toxicologic Neuropathology of Novel Biotherapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Toxicologic Neuropathology of Novel Biotherapeutics.
2382,5668,38028196,10.1016/j.omtn.2023.102065,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;conjugated;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, conjugated, lnp; source title: Astrocyte-targeted siRNA delivery by adenosine-functionalized LNP in mouse TBI model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Astrocyte-targeted siRNA delivery by adenosine-functionalized LNP in mouse TBI model.
2389,5681,37970635,10.1080/17425255.2023.2283524,assay,ASO,PubMed abstract sentence 8,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Predicting the pharmacokinetics and pharmacodynamics of antisense oligonucleotides: an overview of various approaches and opportunities for PBPK/PD modelling.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Predicting the pharmacokinetics and pharmacodynamics of antisense oligonucleotides: an overview of various approaches and opportunities for PBPK/PD modelling.
2391,5685,37956785,10.1016/j.ejpb.2023.11.007,delivery,siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Evaluation of the effects of storage conditions on spray-dried siRNA-LNPs before and after subsequent drying.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of the effects of storage conditions on spray-dried siRNA-LNPs before and after subsequent drying.
2392,5688,37928442,10.1016/j.omtn.2023.102057,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: Efficacy and safety of a SOD1-targeting artificial miRNA delivered by AAV9 in mice are impacted by miRNA scaffold selection.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and safety of a SOD1-targeting artificial miRNA delivered by AAV9 in mice are impacted by miRNA scaffold selection.
2393,5691,37893074,10.3390/biomedicines11102700,assay,ASO,PubMed abstract sentence 8,screen;model,"assay candidate; matched derived terms: screen, model; source title: An Induced Pluripotent Stem Cell-Derived Human Blood-Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,An Induced Pluripotent Stem Cell-Derived Human Blood-Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides.
2399,5707,37773127,10.1186/s12967-023-04548-y,toxicity,ASO/siRNA,PubMed abstract sentence 15,renal;dna damage,"toxicity candidate; matched derived terms: renal, dna damage; source title: Cytosine-phosphate-guanine oligodeoxynucleotides alleviate radiation-induced kidney injury in cervical cancer by inhibiting DNA damage and oxidative stress through blockade of PARP1/XRCC1 axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cytosine-phosphate-guanine oligodeoxynucleotides alleviate radiation-induced kidney injury in cervical cancer by inhibiting DNA damage and oxidative stress through blockade of PARP1/XRCC1 axis.
2401,5713,37717247,10.1021/acs.molpharmaceut.3c00547,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Differences and Similarities of the Intravenously Administered Lipid Nanoparticles in Three Clinical Trials: Potential Linkage between Lipid Nanoparticles and Extracellular Vesicles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Differences and Similarities of the Intravenously Administered Lipid Nanoparticles in Three Clinical Trials: Potential Linkage between Lipid Nanoparticles and Extracellular Vesicles.
2403,5717,37696275,10.1016/S0140-6736(23)01583-0,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial."
2405,5721,37689270,10.1016/j.ntt.2023.107291,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Toxic effects of exogenous retinoic acid on the neurodevelopment of zebrafish (Danio rerio) embryos.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Toxic effects of exogenous retinoic acid on the neurodevelopment of zebrafish (Danio rerio) embryos.
2407,5727,37680985,10.1016/j.omtn.2023.08.020,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Novel hybrid silicon-lipid nanoparticles deliver a siRNA to cure autosomal dominant osteopetrosis in mice. Implications for gene therapy in humans.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel hybrid silicon-lipid nanoparticles deliver a siRNA to cure autosomal dominant osteopetrosis in mice. Implications for gene therapy in humans.
2408,5728,37680985,10.1016/j.omtn.2023.08.020,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Novel hybrid silicon-lipid nanoparticles deliver a siRNA to cure autosomal dominant osteopetrosis in mice. Implications for gene therapy in humans.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Novel hybrid silicon-lipid nanoparticles deliver a siRNA to cure autosomal dominant osteopetrosis in mice. Implications for gene therapy in humans.
2409,5731,37672251,10.1167/tvst.12.9.5,assay,ASO/siRNA,PubMed abstract sentence 13,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Ocular Pharmacology and Toxicology of TRPV1 Antagonist SAF312 (Libvatrep).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ocular Pharmacology and Toxicology of TRPV1 Antagonist SAF312 (Libvatrep).
2410,5732,37672251,10.1167/tvst.12.9.5,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Ocular Pharmacology and Toxicology of TRPV1 Antagonist SAF312 (Libvatrep).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ocular Pharmacology and Toxicology of TRPV1 Antagonist SAF312 (Libvatrep).
2414,5742,37638793,10.1089/nat.2023.0014,chemistry,ASO,PubMed abstract sentence 9,galnac;2'-o;lna;conjugate,"chemistry candidate; matched derived terms: galnac, 2'-o, lna, conjugate; source title: New Oligonucleotide 2'-O-Alkyl N3'→P5' (Thio)-Phosphoramidates as Potent Antisense Agents: Physicochemical Properties and Biological Activity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,New Oligonucleotide 2'-O-Alkyl N3'→P5' (Thio)-Phosphoramidates as Potent Antisense Agents: Physicochemical Properties and Biological Activity.
2415,5747,37579525,10.1016/j.bmc.2023.117442,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pyrrolidinedione-thiazolidinone hybrid molecules with potent cytotoxic effect in squamous cell carcinoma SCC-15 cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pyrrolidinedione-thiazolidinone hybrid molecules with potent cytotoxic effect in squamous cell carcinoma SCC-15 cells.
2416,5750,37566031,10.3390/cells12151952,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.
2417,5753,37522763,10.1097/HCO.0000000000001074,toxicity,ASO/siRNA,PubMed abstract sentence 1,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Inclisiran and cardiovascular events: a comprehensive review of efficacy, safety, and future perspectives.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Inclisiran and cardiovascular events: a comprehensive review of efficacy, safety, and future perspectives."
2419,5757,37479139,10.1016/j.jhep.2023.06.013,toxicity,ASO/siRNA,PubMed abstract sentence 14,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Efficacy and safety of givosiran for acute hepatic porphyria: Final results of the randomized phase III ENVISION trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficacy and safety of givosiran for acute hepatic porphyria: Final results of the randomized phase III ENVISION trial.
2421,5761,37462494,10.1148/radiol.222612,toxicity,ASO/siRNA,PubMed abstract sentence 8,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Efficacy and Safety of Half-Dose Gadopiclenol versus Full-Dose Gadobutrol for Contrast-enhanced Body MRI.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and Safety of Half-Dose Gadopiclenol versus Full-Dose Gadobutrol for Contrast-enhanced Body MRI.
2424,5768,37437196,10.1021/acs.bioconjchem.3c00186,toxicity,ASO,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Blended Block Polycation Micelles Enhance Antisense Oligonucleotide Delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Blended Block Polycation Micelles Enhance Antisense Oligonucleotide Delivery.
2425,5771,37423563,10.1016/j.addr.2023.114990,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications.
2438,5808,37095250,10.1038/s41591-023-02326-3,assay,ASO,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Tau-targeting antisense oligonucleotide MAPT(Rx) in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Tau-targeting antisense oligonucleotide MAPT(Rx) in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial."
2439,5811,37059938,10.1186/s43556-023-00119-1,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CD95/Fas ligand mRNA is toxic to cells through more than one mechanism.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CD95/Fas ligand mRNA is toxic to cells through more than one mechanism.
2441,5817,37003287,10.1016/S0140-6736(23)00284-2,toxicity,ASO/siRNA,PubMed abstract sentence 11,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Efficacy and safety of fitusiran prophylaxis in people with haemophilia A or haemophilia B with inhibitors (ATLAS-INH): a multicentre, open-label, randomised phase 3 trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Efficacy and safety of fitusiran prophylaxis in people with haemophilia A or haemophilia B with inhibitors (ATLAS-INH): a multicentre, open-label, randomised phase 3 trial."
2443,5823,36921725,10.1016/j.jconrel.2023.03.016,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors.
2444,5826,36906918,10.1002/adhm.202203022,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: The Effect of Cryoprotectants and Storage Conditions on the Transfection Efficiency, Stability, and Safety of Lipid-Based Nanoparticles for mRNA and DNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"The Effect of Cryoprotectants and Storage Conditions on the Transfection Efficiency, Stability, and Safety of Lipid-Based Nanoparticles for mRNA and DNA Delivery."
2446,5830,36853331,10.1021/acsnano.2c10936,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles.
2447,5835,36809339,10.1371/journal.pgen.1010598,offtarget,ASO/siRNA,PubMed abstract sentence 14,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Off-target piRNA gene silencing in Drosophila melanogaster rescued by a transposable element insertion.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Off-target piRNA gene silencing in Drosophila melanogaster rescued by a transposable element insertion.
2448,5838,36804094,10.1016/S1474-4422(23)00001-7,assay,ASO,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial."
2450,5846,36701738,10.1097/MD.0000000000032728,toxicity,ASO/siRNA,PubMed abstract sentence 12,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Effectiveness and safety of Inclisiran in hyperlipidemia treatment: An overview of systematic reviews.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Effectiveness and safety of Inclisiran in hyperlipidemia treatment: An overview of systematic reviews.
2451,5851,36620965,10.1016/S2213-8587(22)00353-9,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial.
2453,5855,36617999,10.1039/d2nr05669k,delivery,ASO,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Cancer-cell-membrane-camouflaged supramolecular self-assembly of antisense oligonucleotide and chemodrug for targeted combination therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cancer-cell-membrane-camouflaged supramolecular self-assembly of antisense oligonucleotide and chemodrug for targeted combination therapy.
2458,5866,35913563,10.1007/s00467-022-05684-1,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Efficacy and safety of lumasiran for infants and young children with primary hyperoxaluria type 1: 12-month analysis of the phase 3 ILLUMINATE-B trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficacy and safety of lumasiran for infants and young children with primary hyperoxaluria type 1: 12-month analysis of the phase 3 ILLUMINATE-B trial.
2462,5878,36223135,10.1021/acs.jmedchem.2c00873,chemistry,ASO/siRNA,PubMed abstract sentence 5,modified;2'-o,"chemistry candidate; matched derived terms: modified, 2'-o; source title: Small Interfering RNAs Containing Dioxane- and Morpholino-Derived Nucleotide Analogues Show Improved Off-Target Profiles and Chirality-Dependent In Vivo Knock-Down.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Small Interfering RNAs Containing Dioxane- and Morpholino-Derived Nucleotide Analogues Show Improved Off-Target Profiles and Chirality-Dependent In Vivo Knock-Down.
2463,5879,36223135,10.1021/acs.jmedchem.2c00873,offtarget,ASO/siRNA,PubMed abstract sentence 1,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Small Interfering RNAs Containing Dioxane- and Morpholino-Derived Nucleotide Analogues Show Improved Off-Target Profiles and Chirality-Dependent In Vivo Knock-Down.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Small Interfering RNAs Containing Dioxane- and Morpholino-Derived Nucleotide Analogues Show Improved Off-Target Profiles and Chirality-Dependent In Vivo Knock-Down.
2466,5886,36180936,10.1186/s40824-022-00292-4,delivery,ASO,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nonviral delivery systems for antisense oligonucleotide therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nonviral delivery systems for antisense oligonucleotide therapeutics.
2469,5891,36140196,10.3390/biomedicines10092096,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Multi-Functionalized Heteroduplex Antisense Oligonucleotides for Targeted Intracellular Delivery and Gene Silencing in HeLa Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Multi-Functionalized Heteroduplex Antisense Oligonucleotides for Targeted Intracellular Delivery and Gene Silencing in HeLa Cells.
2472,5896,36115655,10.1016/j.actbio.2022.09.025,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors.
2475,5907,35944903,10.1093/nar/gkac641,delivery,ASO,PubMed abstract sentence 7,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice.
2477,5911,35919168,10.1039/d2ra01999j,chemistry,ASO/siRNA,PubMed abstract sentence 2,galnac;lna,"chemistry candidate; matched derived terms: galnac, lna; source title: Beyond GalNAc! Drug delivery systems comprising complex oligosaccharides for targeted use of nucleic acid therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Beyond GalNAc! Drug delivery systems comprising complex oligosaccharides for targeted use of nucleic acid therapeutics.
2478,5912,35919168,10.1039/d2ra01999j,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: Beyond GalNAc! Drug delivery systems comprising complex oligosaccharides for targeted use of nucleic acid therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Beyond GalNAc! Drug delivery systems comprising complex oligosaccharides for targeted use of nucleic acid therapeutics.
2486,5932,35338587,10.1002/ps.6884,assay,siRNA,PubMed abstract sentence 6,assay;model,"assay candidate; matched derived terms: assay, model; source title: RNA meets toxicology: efficacy indicators from the experimental design of RNAi studies for insect pest management.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA meets toxicology: efficacy indicators from the experimental design of RNAi studies for insect pest management.
2493,5957,34797690,10.1089/nat.2021.0059,delivery,ASO,PubMed abstract sentence 4,delivery;galnac;conjugated,"delivery candidate; matched derived terms: delivery, galnac, conjugated; source title: Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging.
2503,5983,34505766,10.1021/acsnano.1c05099,chemistry,ASO,PubMed abstract sentence 4,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles."
2508,5994,34337865,10.1002/smll.202103025,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery.
2510,5998,34242101,10.1089/nat.2020.0917,assay,ASO,PubMed abstract sentence 1,screen;preclinical,"assay candidate; matched derived terms: screen, preclinical; source title: Improvements in the Tolerability Profile of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Improvements in the Tolerability Profile of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods."
2511,5999,34242101,10.1089/nat.2020.0917,toxicity,ASO,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Improvements in the Tolerability Profile of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Improvements in the Tolerability Profile of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods."
2512,6002,34227307,10.3724/SP.J.1123.2020.10001,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: [Highly toxic type Ⅱ ribosome-inactivating proteins ricin and abrin and their detection methods: a review].",B,high_candidate,curator_rejected,reject,derived_annotations_only,[Highly toxic type Ⅱ ribosome-inactivating proteins ricin and abrin and their detection methods: a review].
2513,6005,34224372,10.1158/0008-5472.CAN-21-0953,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Ratio of Toxic-to-Nontoxic miRNAs Predicts Platinum Sensitivity in Ovarian Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Ratio of Toxic-to-Nontoxic miRNAs Predicts Platinum Sensitivity in Ovarian Cancer.
2514,6010,34189917,10.1021/acs.nanolett.1c01353,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device.
2518,6026,33974806,10.1146/annurev-anchem-091620-091335,assay,ASO/siRNA,PubMed abstract sentence 4,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Environmental Toxicology Assays Using Organ-on-Chip.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Environmental Toxicology Assays Using Organ-on-Chip.
2519,6027,33974806,10.1146/annurev-anchem-091620-091335,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: Environmental Toxicology Assays Using Organ-on-Chip.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Environmental Toxicology Assays Using Organ-on-Chip.
2522,6036,33798466,10.1016/S2213-8587(21)00046-2,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial."
2523,6037,33798466,10.1016/S2213-8587(21)00046-2,toxicity,ASO/siRNA,PubMed abstract sentence 16,adverse;tolerability,"toxicity candidate; matched derived terms: adverse, tolerability; source title: Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial."
2530,6056,32865790,10.1007/978-1-0716-0771-8_12,chemistry,ASO,PubMed abstract sentence 6,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Albumin-Binding Fatty Acid-Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Albumin-Binding Fatty Acid-Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics.
2531,6061,32610253,10.1016/j.omtn.2020.05.010,chemistry,siRNA,PubMed abstract sentence 3,chemical;modification;modified,"chemistry candidate; matched derived terms: chemical, modification, modified; source title: 2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA.",B,high_candidate,curator_verified,accept,derived_annotations_only,2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA.
2534,6068,32555332,10.1038/s41388-020-1360-y,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Profiling cytotoxic microRNAs in pediatric and adult glioblastoma cells by high-content screening, identification, and validation of miR-1300.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Profiling cytotoxic microRNAs in pediatric and adult glioblastoma cells by high-content screening, identification, and validation of miR-1300."
2535,6069,32555332,10.1038/s41388-020-1360-y,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Profiling cytotoxic microRNAs in pediatric and adult glioblastoma cells by high-content screening, identification, and validation of miR-1300.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Profiling cytotoxic microRNAs in pediatric and adult glioblastoma cells by high-content screening, identification, and validation of miR-1300."
2536,6072,32430618,10.1007/s00210-020-01896-0,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Silencing of tissue factor by antisense deoxyoligonucleotide mitigates thioacetamide-induced liver injury.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing of tissue factor by antisense deoxyoligonucleotide mitigates thioacetamide-induced liver injury.
2544,6094,32091909,10.1021/acs.molpharmaceut.0c00087,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Improved Stability of siRNA-Loaded Lipid Nanoparticles Prepared with a PEG-Monoacyl Fatty Acid Facilitates Ligand-Mediated siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Improved Stability of siRNA-Loaded Lipid Nanoparticles Prepared with a PEG-Monoacyl Fatty Acid Facilitates Ligand-Mediated siRNA Delivery.
2547,6099,32070342,10.1186/s12951-020-0586-8,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Triazine-cored polymeric vectors for antisense oligonucleotide delivery in vitro and in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Triazine-cored polymeric vectors for antisense oligonucleotide delivery in vitro and in vivo.
2548,6104,32043907,10.1089/nat.2019.0829,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia.
2549,6107,31863870,10.1016/j.toxlet.2019.12.024,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Comparison of the toxic mechanism of T-2 toxin and deoxynivalenol on human chondrocytes by microarray and bioinformatics analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comparison of the toxic mechanism of T-2 toxin and deoxynivalenol on human chondrocytes by microarray and bioinformatics analysis.
2556,6126,30988454,10.1038/s41598-019-42523-0,chemistry,ASO,PubMed abstract sentence 9,modification;modified;2'-o;lna,"chemistry candidate; matched derived terms: modification, modified, 2'-o, lna; source title: Systematic evaluation of 2'-Fluoro modified chimeric antisense oligonucleotide-mediated exon skipping in vitro.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Systematic evaluation of 2'-Fluoro modified chimeric antisense oligonucleotide-mediated exon skipping in vitro.
2558,6132,30576769,10.1016/j.jcmgh.2018.12.004,delivery,ASO,PubMed abstract sentence 5,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.
2559,6133,30576769,10.1016/j.jcmgh.2018.12.004,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic;tolerability,"toxicity candidate; matched derived terms: toxicity, toxic, tolerability; source title: Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.
2562,6142,29858054,10.1016/j.omtn.2018.02.004,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice.
2564,6148,29669851,10.1126/scitranslmed.aan0713,assay,ASO,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy.
2570,6164,30970855,10.3390/polym9050177,chemistry,ASO,PubMed abstract sentence 2,modified;conjugate,"chemistry candidate; matched derived terms: modified, conjugate; source title: Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice.
2571,6169,28799823,10.1089/nat.2017.0676,chemistry,ASO,PubMed abstract sentence 1,modified;2'-o;2'-moe,"chemistry candidate; matched derived terms: modified, 2'-o, 2'-moe; source title: Lack of QT Prolongation for 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lack of QT Prolongation for 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects.
2577,6183,27956144,10.1016/j.jconrel.2016.12.005,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Self-aggregating 1.8kDa polyethylenimines with dissolution switch at endosomal acidic pH are delivery carriers for plasmid DNA, mRNA, siRNA and exon-skipping oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Self-aggregating 1.8kDa polyethylenimines with dissolution switch at endosomal acidic pH are delivery carriers for plasmid DNA, mRNA, siRNA and exon-skipping oligonucleotides."
2579,6187,27854228,10.3233/JND-160157,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Toxicological Characterization of Exon Skipping Phosphorodiamidate Morpholino Oligomers (PMOs) in Non-human Primates.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Toxicological Characterization of Exon Skipping Phosphorodiamidate Morpholino Oligomers (PMOs) in Non-human Primates.
2582,6200,27138177,10.1038/mtna.2016.26,chemistry,ASO,PubMed abstract sentence 2,modified;galnac;2'-o;lna;conjugate,"chemistry candidate; matched derived terms: modified, galnac, 2'-o, lna, conjugate; source title: Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice.
2583,6201,27138177,10.1038/mtna.2016.26,delivery,ASO,PubMed abstract sentence 1,galnac;conjugated;uptake,"delivery candidate; matched derived terms: galnac, conjugated, uptake; source title: Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice.
2584,6204,26855051,10.1016/j.jconrel.2016.02.007,chemistry,ASO,PubMed abstract sentence 9,phosphorothioate;conjugate,"chemistry candidate; matched derived terms: phosphorothioate, conjugate; source title: Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides."
2590,6220,26366082,10.2147/IJN.S89910,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cationic polyelectrolyte-mediated delivery of antisense morpholino oligonucleotides for exon-skipping in vitro and in mdx mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cationic polyelectrolyte-mediated delivery of antisense morpholino oligonucleotides for exon-skipping in vitro and in mdx mice.
2591,6223,26338776,10.1093/nar/gkv857,offtarget,ASO,PubMed abstract sentence 3,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.
2592,6226,26334953,10.1089/nat.2015.0550,chemistry,siRNA,PubMed abstract sentence 5,modification;lna,"chemistry candidate; matched derived terms: modification, lna; source title: Targeting Cancer Cells Using LNA-Modified Aptamer-siRNA Chimeras.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting Cancer Cells Using LNA-Modified Aptamer-siRNA Chimeras.
2593,6231,26042553,10.1021/acs.nanolett.5b00490,delivery,ASO,PubMed abstract sentence 2,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.
2594,6234,25711857,10.1016/j.taap.2015.02.014,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions.
2595,6237,25539920,10.1093/nar/gku1343,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors.
2597,6241,25453815,10.1016/j.bmcl.2014.10.045,chemistry,ASO,PubMed abstract sentence 6,modified;phosphorothioate;conjugate,"chemistry candidate; matched derived terms: modified, phosphorothioate, conjugate; source title: Oligonucleotides conjugated with short chemically defined polyethylene glycol chains are efficient antisense agents.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oligonucleotides conjugated with short chemically defined polyethylene glycol chains are efficient antisense agents.
2600,6248,25209738,10.1016/S1474-4422(14)70195-4,toxicity,ASO/siRNA,PubMed abstract sentence 7,safety;adverse;renal,"toxicity candidate; matched derived terms: safety, adverse, renal; source title: Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study."
2605,6257,24932560,10.3109/08958378.2014.907587,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Local and systemic tolerability of a 2'O-methoxyethyl antisense oligonucleotide targeting interleukin-4 receptor-α delivery by inhalation in mouse and monkey.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Local and systemic tolerability of a 2'O-methoxyethyl antisense oligonucleotide targeting interleukin-4 receptor-α delivery by inhalation in mouse and monkey.
2610,6274,21982682,10.1016/j.urolonc.2011.09.002,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Immunostimulatory CpG-DNA and PSA-peptide vaccination elicits profound cytotoxic T cell responses.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Immunostimulatory CpG-DNA and PSA-peptide vaccination elicits profound cytotoxic T cell responses.
2611,6277,23344237,10.1038/mtna.2012.32,chemistry,siRNA,PubMed abstract sentence 5,modified;phosphorothioate;2'-o;lna,"chemistry candidate; matched derived terms: modified, phosphorothioate, 2'-o, lna; source title: Development of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Development of a 2',4'-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo."
2613,6283,22800522,10.3760/cma.j.issn.0529-5807.2012.04.009,assay,ASO,PubMed abstract sentence 4,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: [Study on effects of microRNA-21 antisense oligonucleotide in vivo and in vitro on bionomics of human cervical squamous carcinoma cell lines SiHa].",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,[Study on effects of microRNA-21 antisense oligonucleotide in vivo and in vitro on bionomics of human cervical squamous carcinoma cell lines SiHa].
2620,6304,21540336,10.1177/1091581811403505,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Repeat-dose toxicology evaluation in cynomolgus monkeys of AVI-4658, a phosphorodiamidate morpholino oligomer (PMO) drug for the treatment of duchenne muscular dystrophy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Repeat-dose toxicology evaluation in cynomolgus monkeys of AVI-4658, a phosphorodiamidate morpholino oligomer (PMO) drug for the treatment of duchenne muscular dystrophy."
2622,6308,21540335,10.1177/1091581811403504,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Chemical and mechanistic toxicology evaluation of exon skipping phosphorodiamidate morpholino oligomers in mdx mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical and mechanistic toxicology evaluation of exon skipping phosphorodiamidate morpholino oligomers in mdx mice.
2623,6309,21540335,10.1177/1091581811403504,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chemical and mechanistic toxicology evaluation of exon skipping phosphorodiamidate morpholino oligomers in mdx mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chemical and mechanistic toxicology evaluation of exon skipping phosphorodiamidate morpholino oligomers in mdx mice.
2624,6312,21041954,10.1172/JCI42958,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2.
2626,6320,20128628,10.1021/mp900220p,chemistry,ASO,PubMed abstract sentence 1,modification;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: modification, phosphorothioate, 2'-o; source title: Formulation and delivery of splice-correction antisense oligonucleotides by amino acid modified polyethylenimine.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Formulation and delivery of splice-correction antisense oligonucleotides by amino acid modified polyethylenimine.
2629,6325,19854938,10.1093/nar/gkp841,chemistry,ASO,PubMed abstract sentence 5,phosphorothioate;lna,"chemistry candidate; matched derived terms: phosphorothioate, lna; source title: Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents."
2631,6327,19854938,10.1093/nar/gkp841,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents."
2637,6345,42174621,10.1186/s12967-026-07782-2,assay,ASO/siRNA,PubMed abstract sentence 4,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Targeting C5AR1 disrupts complement-driven G0-phase maintenance and overcomes metabolic drug resistance in glioma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting C5AR1 disrupts complement-driven G0-phase maintenance and overcomes metabolic drug resistance in glioma.
2639,6349,42128564,10.1016/j.aca.2026.345575,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;phosphorothioate,"chemistry candidate; matched derived terms: chemical, phosphorothioate; source title: The integration of peptoid and phosphorothioate aptamer into electrochemical biosensors for the robust antifouling detection of prostate-specific antigen in human serum.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The integration of peptoid and phosphorothioate aptamer into electrochemical biosensors for the robust antifouling detection of prostate-specific antigen in human serum.
2644,6364,42069296,10.1016/j.lfs.2026.124421,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxic;renal,"toxicity candidate; matched derived terms: toxic, renal; source title: GSTK1 alleviates ectopic fat deposition as a protective mechanism against diabetic renal tubulointerstitial lesions.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,GSTK1 alleviates ectopic fat deposition as a protective mechanism against diabetic renal tubulointerstitial lesions.
2652,6384,41963231,10.1016/j.acra.2026.03.027,toxicity,ASO/siRNA,PubMed abstract sentence 2,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: The Rapid Long-axis Strain-based Prognostic Models Evaluate Composite Adverse Events for Asymptomatic Dextro-Transposition of the Great Arteries Patients after the Switch Operation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Rapid Long-axis Strain-based Prognostic Models Evaluate Composite Adverse Events for Asymptomatic Dextro-Transposition of the Great Arteries Patients after the Switch Operation.
2653,6385,41963231,10.1016/j.acra.2026.03.027,benchmark,ASO/siRNA,PubMed abstract sentence 2,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: The Rapid Long-axis Strain-based Prognostic Models Evaluate Composite Adverse Events for Asymptomatic Dextro-Transposition of the Great Arteries Patients after the Switch Operation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Rapid Long-axis Strain-based Prognostic Models Evaluate Composite Adverse Events for Asymptomatic Dextro-Transposition of the Great Arteries Patients after the Switch Operation.
2659,6403,41887640,10.1136/bmjopen-2025-111798,assay,ASO/siRNA,PubMed abstract sentence 7,experiment;trial,"assay candidate; matched derived terms: experiment, trial; source title: Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial.
2674,6442,41766648,10.1093/bib/bbag092,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Transformer-based multidimensional feature fusion for accurate prediction of lipid nanoparticles transfection efficiency.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transformer-based multidimensional feature fusion for accurate prediction of lipid nanoparticles transfection efficiency.
2675,6443,41766648,10.1093/bib/bbag092,benchmark,ASO/siRNA,PubMed abstract sentence 4,prediction;benchmark;dataset,"benchmark candidate; matched derived terms: prediction, benchmark, dataset; source title: Transformer-based multidimensional feature fusion for accurate prediction of lipid nanoparticles transfection efficiency.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transformer-based multidimensional feature fusion for accurate prediction of lipid nanoparticles transfection efficiency.
2683,6467,41569356,10.1007/s00299-026-03713-z,offtarget,ASO/siRNA,PubMed abstract sentence 8,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: The function of OsRAD51A1 gene in meiotic stability and high seed-setting rate of tetraploid rice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The function of OsRAD51A1 gene in meiotic stability and high seed-setting rate of tetraploid rice.
2685,6473,41548848,10.1016/j.addr.2026.115780,delivery,ASO/siRNA,PubMed abstract sentence 8,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Technology for Nucleic Acid Delivery in the Treatment of Hematological Malignancies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Technology for Nucleic Acid Delivery in the Treatment of Hematological Malignancies.
2688,6480,41526546,10.1038/s41598-025-33359-y,assay,ASO/siRNA,PubMed abstract sentence 7,assay;model,"assay candidate; matched derived terms: assay, model; source title: The contribution of the membrane-bound complement regulatory proteins CD46 and CD55 in phases of acute lymphocytic leukemia and acute myelogenous leukemia.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The contribution of the membrane-bound complement regulatory proteins CD46 and CD55 in phases of acute lymphocytic leukemia and acute myelogenous leukemia.
2698,6506,41285241,10.1016/j.jconrel.2025.114453,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Hypoxia-responsive modules via tunable hydrophobicity reversal enhance renal-targeted release of CD36-interfering nanoparticles to ameliorate acute kidney injury.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hypoxia-responsive modules via tunable hydrophobicity reversal enhance renal-targeted release of CD36-interfering nanoparticles to ameliorate acute kidney injury.
2709,6533,41465224,10.3390/ijms262411791,chemistry,siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Two-Stage Probability-Enhanced Regression on Property Matrices and LLM Embeddings Enables State-of-the-Art Prediction of Gene Knockdown by Modified siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Two-Stage Probability-Enhanced Regression on Property Matrices and LLM Embeddings Enables State-of-the-Art Prediction of Gene Knockdown by Modified siRNAs.
2710,6534,41465224,10.3390/ijms262411791,benchmark,siRNA,PubMed abstract sentence 5,model;benchmark,"benchmark candidate; matched derived terms: model, benchmark; source title: Two-Stage Probability-Enhanced Regression on Property Matrices and LLM Embeddings Enables State-of-the-Art Prediction of Gene Knockdown by Modified siRNAs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Two-Stage Probability-Enhanced Regression on Property Matrices and LLM Embeddings Enables State-of-the-Art Prediction of Gene Knockdown by Modified siRNAs.
2729,6585,41033366,10.1016/j.micpath.2025.108077,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Antiviral effects and mechanism of fully phosphorothioate-modified CpG-ODN 2216 in fish and human cell lines in vitro.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antiviral effects and mechanism of fully phosphorothioate-modified CpG-ODN 2216 in fish and human cell lines in vitro.
2738,6608,40902397,10.1016/j.intimp.2025.115419,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Bruceine A derivative P1 alleviates renal inflammation via Tnfrsf12a pathway in diabetic nephropathy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bruceine A derivative P1 alleviates renal inflammation via Tnfrsf12a pathway in diabetic nephropathy.
2740,6612,40886601,10.1016/j.ecoenv.2025.118920,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tetrabromophthalate bis(2-ethylhexyl) ester (TBPH) exposure induces renal inflammation injury by activating MAVS-IRF3 signaling pathway in vitro and in vivo models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tetrabromophthalate bis(2-ethylhexyl) ester (TBPH) exposure induces renal inflammation injury by activating MAVS-IRF3 signaling pathway in vitro and in vivo models.
2749,6635,40779327,10.34067/KID.0000000945,assay,ASO/siRNA,PubMed abstract sentence 5,preclinical;model;rna-seq,"assay candidate; matched derived terms: preclinical, model, rna-seq; source title: Renal Single-Nuclear Transcriptomics Identifies Novel Therapeutic Targets in a Preclinical Model of CKD.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Renal Single-Nuclear Transcriptomics Identifies Novel Therapeutic Targets in a Preclinical Model of CKD.
2772,6686,40544826,10.1159/000546897,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ACOT4 and ACOT6 Activate Akt-mTOR Pathway and Inhibit Calcium Oxalate-Induced Renal Tubular Cell Injury.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ACOT4 and ACOT6 Activate Akt-mTOR Pathway and Inhibit Calcium Oxalate-Induced Renal Tubular Cell Injury.
2791,6733,40194620,10.1016/j.jmb.2025.169131,chemistry,siRNA,PubMed abstract sentence 4,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: ENsiRNA: A Multimodality Method for siRNA-mRNA and Modified siRNA Efficacy Prediction Based on Geometric Graph Neural Network.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,ENsiRNA: A Multimodality Method for siRNA-mRNA and Modified siRNA Efficacy Prediction Based on Geometric Graph Neural Network.
2792,6734,40194620,10.1016/j.jmb.2025.169131,benchmark,siRNA,PubMed abstract sentence 4,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: ENsiRNA: A Multimodality Method for siRNA-mRNA and Modified siRNA Efficacy Prediction Based on Geometric Graph Neural Network.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,ENsiRNA: A Multimodality Method for siRNA-mRNA and Modified siRNA Efficacy Prediction Based on Geometric Graph Neural Network.
2793,6737,40184793,10.1016/j.bbrc.2025.151718,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Prediction and control of the particle size of polyethylene glycol-free lipid nanoparticles using a design of experiment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prediction and control of the particle size of polyethylene glycol-free lipid nanoparticles using a design of experiment.
2795,6741,40171444,10.1016/j.omtn.2024.102415,chemistry,siRNA,PubMed abstract sentence 2,chemical;modification;modified,"chemistry candidate; matched derived terms: chemical, modification, modified; source title: Improving the potency prediction for chemically modified siRNAs through insights from molecular modeling of individual sequence positions.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Improving the potency prediction for chemically modified siRNAs through insights from molecular modeling of individual sequence positions.
2796,6742,40171444,10.1016/j.omtn.2024.102415,assay,siRNA,PubMed abstract sentence 3,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Improving the potency prediction for chemically modified siRNAs through insights from molecular modeling of individual sequence positions.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Improving the potency prediction for chemically modified siRNAs through insights from molecular modeling of individual sequence positions.
2815,6791,39732963,10.1038/s41598-024-83263-0,benchmark,ASO/siRNA,PubMed abstract sentence 9,model;dataset,"benchmark candidate; matched derived terms: model, dataset; source title: Development and validation of a prognostic model based on m6A-related lncRNAs to predict prognosis for papillary renal cell cancer patients.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development and validation of a prognostic model based on m6A-related lncRNAs to predict prognosis for papillary renal cell cancer patients.
2823,6811,39321261,10.1093/bioinformatics/btae577,benchmark,siRNA,PubMed abstract sentence 2,prediction;dataset,"benchmark candidate; matched derived terms: prediction, dataset; source title: OligoFormer: an accurate and robust prediction method for siRNA design.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,OligoFormer: an accurate and robust prediction method for siRNA design.
2836,6842,39143486,10.1186/s12967-024-05575-z,assay,ASO/siRNA,PubMed abstract sentence 13,screen;model,"assay candidate; matched derived terms: screen, model; source title: Urine-derived podocytes from steroid resistant nephrotic syndrome patients as a model for renal-progenitor derived extracellular vesicles effect and drug screening.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Urine-derived podocytes from steroid resistant nephrotic syndrome patients as a model for renal-progenitor derived extracellular vesicles effect and drug screening.
2840,6850,39053673,10.1016/j.cellsig.2024.111313,assay,ASO/siRNA,PubMed abstract sentence 10,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma.
2842,6852,39053673,10.1016/j.cellsig.2024.111313,benchmark,ASO/siRNA,PubMed abstract sentence 8,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Methylation and transcriptome analyses construct a prognostic model and reveal the suppressor role of VMO1 in lung adenocarcinoma.
2843,6855,38910412,10.2174/011871529X297081240613075328,toxicity,ASO/siRNA,PubMed abstract sentence 6,risk;hematological,"toxicity candidate; matched derived terms: risk, hematological; source title: Hematological Indices and Genetic Variants of Premature Ovarian Insufficiency: Machine Learning Approaches.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hematological Indices and Genetic Variants of Premature Ovarian Insufficiency: Machine Learning Approaches.
2854,6880,38652038,10.1158/1078-0432.CCR-23-3029,toxicity,ASO/siRNA,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma.
2865,6911,38351116,10.1038/s41598-024-53346-z,assay,ASO/siRNA,PubMed abstract sentence 10,screen;model,"assay candidate; matched derived terms: screen, model; source title: Whole transcriptome screening for novel genes involved in meiosis and fertility in Drosophila melanogaster.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Whole transcriptome screening for novel genes involved in meiosis and fertility in Drosophila melanogaster.
2872,6926,38287070,10.1038/s41598-024-52685-1,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: A careful look at lipid nanoparticle characterization: analysis of benchmark formulations for encapsulation of RNA cargo size gradient.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A careful look at lipid nanoparticle characterization: analysis of benchmark formulations for encapsulation of RNA cargo size gradient.
2879,6941,37930224,10.1097/HPC.0000000000000340,toxicity,ASO/siRNA,PubMed abstract sentence 2,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Serious Adverse Events of Inclisiran in Patients With Hypercholesterolemia, a Meta-Analysis of ORION Trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Serious Adverse Events of Inclisiran in Patients With Hypercholesterolemia, a Meta-Analysis of ORION Trials."
2885,6957,37876253,10.1039/d3cp02820h,chemistry,ASO/siRNA,PubMed abstract sentence 1,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Understanding base and backbone contributions of phosphorothioate DNA for molecular recognition with SBD proteins.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Understanding base and backbone contributions of phosphorothioate DNA for molecular recognition with SBD proteins.
2904,7002,37448891,10.4103/ijn.IJN_462_20,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Donor-Specific Antibody Detection by Single-Antigen Bead Assay for Renal Transplantation: A 2-Year Experience from South India.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Donor-Specific Antibody Detection by Single-Antigen Bead Assay for Renal Transplantation: A 2-Year Experience from South India.
2908,7014,37269857,10.1016/S1470-2045(23)00159-6,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Prevention and management of adverse events during treatment with bispecific antibodies and CAR T cells in multiple myeloma: a consensus report of the European Myeloma Network.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Prevention and management of adverse events during treatment with bispecific antibodies and CAR T cells in multiple myeloma: a consensus report of the European Myeloma Network.
2926,7060,36371910,10.1016/j.psj.2022.102263,offtarget,ASO/siRNA,PubMed abstract sentence 3,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Transcriptome alterations in chicken HD11 cells with steady knockdown and overexpression of RIPK2 gene.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transcriptome alterations in chicken HD11 cells with steady knockdown and overexpression of RIPK2 gene.
2928,7066,36124719,10.1093/nar/gkac774,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;modified;phosphorothioate,"chemistry candidate; matched derived terms: chemical, modified, phosphorothioate; source title: Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.
2930,7072,36484984,10.1021/acs.biochem.2c00590,chemistry,ASO/siRNA,PubMed abstract sentence 2,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product.
2934,7082,36291024,10.3390/bios12100887,chemistry,ASO/siRNA,PubMed abstract sentence 4,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: A Sensitive Aptamer Fluorescence Anisotropy Sensor for Cd(2+) Using Affinity-Enhanced Aptamers with Phosphorothioate Modification.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Sensitive Aptamer Fluorescence Anisotropy Sensor for Cd(2+) Using Affinity-Enhanced Aptamers with Phosphorothioate Modification.
2969,7179,34109445,10.1007/s00216-021-03444-y,assay,ASO/siRNA,PubMed abstract sentence 4,assay;model,"assay candidate; matched derived terms: assay, model; source title: Unraveling the effect of the aptamer complementary element on the performance of duplexed aptamers: a thermodynamic study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unraveling the effect of the aptamer complementary element on the performance of duplexed aptamers: a thermodynamic study.
2979,7205,33625415,10.1039/d0cc08109d,toxicity,ASO/siRNA,PubMed abstract sentence 1,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Inhibition of thrombin activity by a covalent-binding aptamer and reversal by the complementary strand antidote.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of thrombin activity by a covalent-binding aptamer and reversal by the complementary strand antidote.
2983,7213,33439620,10.1021/acschembio.0c00864,chemistry,ASO/siRNA,PubMed abstract sentence 2,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect.
2993,7237,33013736,10.3389/fmicb.2020.01960,chemistry,ASO/siRNA,PubMed abstract sentence 1,modification;modified,"chemistry candidate; matched derived terms: modification, modified; source title: Protein Domain Guided Screen for Sequence Specific and Phosphorothioate-Dependent Restriction Endonucleases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Protein Domain Guided Screen for Sequence Specific and Phosphorothioate-Dependent Restriction Endonucleases.
2999,7251,32683519,10.1007/s10858-020-00333-x,chemistry,ASO/siRNA,PubMed abstract sentence 8,chemical;modification;phosphorothioate,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate; source title: Racemic phosphorothioate as a tool for NMR investigations of protein-DNA complexes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Racemic phosphorothioate as a tool for NMR investigations of protein-DNA complexes.
3011,7287,32187371,10.1093/nar/gkaa170,chemistry,ASO/siRNA,PubMed abstract sentence 1,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts.
3019,7309,31916084,10.1007/s11103-020-00963-7,offtarget,ASO/siRNA,PubMed abstract sentence 1,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: SlCAND1, encoding cullin-associated Nedd8-dissociated protein 1, regulates plant height, flowering time, seed germination, and root architecture in tomato.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"SlCAND1, encoding cullin-associated Nedd8-dissociated protein 1, regulates plant height, flowering time, seed germination, and root architecture in tomato."
3027,7329,31034558,10.1093/nar/gkz247,chemistry,ASO,PubMed abstract sentence 1,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.
3028,7332,26393365,10.1021/acs.analchem.5b02568,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Desulfurization Activated Phosphorothioate DNAzyme for the Detection of Thallium.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Desulfurization Activated Phosphorothioate DNAzyme for the Detection of Thallium.
3029,7335,25711235,10.1093/toxsci/kfv043,chemistry,ASO/siRNA,PubMed abstract sentence 1,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Re-evaluation of the Mutagenic Response to Phosphorothioate Nucleotides in Human Lymphoblastoid TK6 Cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Re-evaluation of the Mutagenic Response to Phosphorothioate Nucleotides in Human Lymphoblastoid TK6 Cells.
3031,7341,24851672,10.1021/ac501070a,chemistry,ASO/siRNA,PubMed abstract sentence 4,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Sensing parts-per-trillion Cd(2+), Hg(2+), and Pb(2+) collectively and individually using phosphorothioate DNAzymes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Sensing parts-per-trillion Cd(2+), Hg(2+), and Pb(2+) collectively and individually using phosphorothioate DNAzymes."
3032,7344,23289794,10.1111/imm.12063,chemistry,ASO/siRNA,PubMed abstract sentence 5,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Phosphorothioate-modified CpG oligodeoxynucleotides mimic autoantigens and reveal a potential role for Toll-like receptor 9 in receptor revision.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phosphorothioate-modified CpG oligodeoxynucleotides mimic autoantigens and reveal a potential role for Toll-like receptor 9 in receptor revision.
3037,7357,20625151,10.1128/AAC.00367-10,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Phosphorothioate 2' deoxyribose oligomers as microbicides that inhibit human immunodeficiency virus type 1 (HIV-1) infection and block Toll-like receptor 7 (TLR7) and TLR9 triggering by HIV-1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phosphorothioate 2' deoxyribose oligomers as microbicides that inhibit human immunodeficiency virus type 1 (HIV-1) infection and block Toll-like receptor 7 (TLR7) and TLR9 triggering by HIV-1.
3038,7360,20410931,10.1038/gt.2010.52,chemistry,ASO/siRNA,PubMed abstract sentence 3,phosphorothioate;2'-o,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o; source title: Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo.
3040,7364,42219707,10.1021/acs.joc.6c00290,chemistry,ASO,PubMed abstract sentence 5,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Synthesis of Peptide-Oligonucleotide Conjugates via Condensation of a Lysine Side-Chain with a Thioester.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synthesis of Peptide-Oligonucleotide Conjugates via Condensation of a Lysine Side-Chain with a Thioester.
3045,7371,42211693,10.1016/j.omtn.2026.102943,benchmark,siRNA,PubMed abstract sentence 5,model;dataset,"benchmark candidate; matched derived terms: model, dataset; source title: Evaluation and forecasting of siRNA delivery technologies: An analysis of hierarchical decision model based on patent data.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation and forecasting of siRNA delivery technologies: An analysis of hierarchical decision model based on patent data.
3046,7374,42210616,10.1021/acsnano.6c00334,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Navigating the Biomolecular Corona: Biological Interactions and Therapeutic Implications of RNA-Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Navigating the Biomolecular Corona: Biological Interactions and Therapeutic Implications of RNA-Lipid Nanoparticles.
3052,7390,42160160,10.1021/acsnano.5c21719,delivery,ASO/siRNA,PubMed abstract sentence 10,delivery;conjugated;lnp,"delivery candidate; matched derived terms: delivery, conjugated, lnp; source title: Post-Conjugation Process for Antibody-Conjugated Lipid Nanoparticles Enabling Tunable Antibody Surface Density for Targeted RNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Post-Conjugation Process for Antibody-Conjugated Lipid Nanoparticles Enabling Tunable Antibody Surface Density for Targeted RNA Delivery.
3054,7394,42150080,10.1073/pnas.2528477123,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;lnp;route,"delivery candidate; matched derived terms: delivery, lnp, route; source title: A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing.
3056,7398,42146191,10.1021/acsomega.6c00100,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Understanding Size Distributions during Lipid Nanoparticle Manufacturing through Mechanistic Modeling.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Understanding Size Distributions during Lipid Nanoparticle Manufacturing through Mechanistic Modeling.
3057,7399,42146191,10.1021/acsomega.6c00100,assay,ASO/siRNA,PubMed abstract sentence 5,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Understanding Size Distributions during Lipid Nanoparticle Manufacturing through Mechanistic Modeling.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Understanding Size Distributions during Lipid Nanoparticle Manufacturing through Mechanistic Modeling.
3060,7406,42140392,10.1016/j.jconrel.2026.115023,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Innovative lipid nanoparticle formulations: Bridging the gap toward decentralized personalized gene therapies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Innovative lipid nanoparticle formulations: Bridging the gap toward decentralized personalized gene therapies.
3064,7418,42135550,10.1007/s00216-026-06556-5,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: LC-HRMS detection of three ionizable lipids in equine plasma: surrogate markers for long-term LNP-mediated gene-doping surveillance.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,LC-HRMS detection of three ionizable lipids in equine plasma: surrogate markers for long-term LNP-mediated gene-doping surveillance.
3065,7421,42132215,10.1021/acs.analchem.6c00816,chemistry,ASO,PubMed abstract sentence 3,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Quantitation of Diastereomer Content in PS-Modified Synthetic Oligonucleotides using cIMS-MS.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Quantitation of Diastereomer Content in PS-Modified Synthetic Oligonucleotides using cIMS-MS.
3068,7430,42117531,10.1021/acsami.6c05213,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid Nanoparticle Surface Engineering with Heparosan Polysaccharides for Safe and Effective mRNA Delivery In Vitro and In Vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticle Surface Engineering with Heparosan Polysaccharides for Safe and Effective mRNA Delivery In Vitro and In Vivo.
3070,7434,42105961,10.1016/j.ijpharm.2026.126948,delivery,siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Cyclodextrin platforms for siRNA delivery: turning design into new therapies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cyclodextrin platforms for siRNA delivery: turning design into new therapies.
3072,7438,42105437,10.1016/j.neurot.2026.e00917,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice.
3075,7447,42070739,10.1016/j.ijpharm.2026.126944,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Exploring the impact of nucleotide length on lipid nanoparticle structure and properties.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exploring the impact of nucleotide length on lipid nanoparticle structure and properties.
3079,7455,42050330,10.1038/s41587-026-03109-0,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery.
3081,7457,42050330,10.1038/s41587-026-03109-0,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery.
3083,7463,42037220,10.1021/acsinfecdis.6c00095,chemistry,siRNA,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Rational Design and Screening of Chemically Modified Anti-SARS-CoV-2 siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rational Design and Screening of Chemically Modified Anti-SARS-CoV-2 siRNA.
3090,7486,41996033,10.1002/smll.202514547,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Osmotic Pressure-Driven Lipid Nanoparticles Enable Potent Cytosolic Delivery of Nucleic Acids.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Osmotic Pressure-Driven Lipid Nanoparticles Enable Potent Cytosolic Delivery of Nucleic Acids.
3091,7487,41996033,10.1002/smll.202514547,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Osmotic Pressure-Driven Lipid Nanoparticles Enable Potent Cytosolic Delivery of Nucleic Acids.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Osmotic Pressure-Driven Lipid Nanoparticles Enable Potent Cytosolic Delivery of Nucleic Acids.
3094,7498,41959436,10.64898/2026.03.31.715590,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses.
3100,7518,41931102,10.1021/acs.molpharmaceut.5c01760,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Formulation Screening of Lipid Nanoparticles Enhances mRNA Delivery to Retina.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Formulation Screening of Lipid Nanoparticles Enhances mRNA Delivery to Retina.
3102,7520,41931102,10.1021/acs.molpharmaceut.5c01760,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Formulation Screening of Lipid Nanoparticles Enhances mRNA Delivery to Retina.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Formulation Screening of Lipid Nanoparticles Enhances mRNA Delivery to Retina.
3111,7539,41898774,10.3390/ijms27062915,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Functional siRNA Delivery via Jet Nebulization: Proof-of-Concept IL-1ß Silencing in Macrophage-like THP-1 Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Functional siRNA Delivery via Jet Nebulization: Proof-of-Concept IL-1ß Silencing in Macrophage-like THP-1 Cells.
3114,7546,41889911,10.64898/2026.03.20.712457,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Structure-Activity Mapping of Intraperitoneal mRNA-LNPs: Decoupling Tumor and Liver Biodistribution in Pancreatic Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structure-Activity Mapping of Intraperitoneal mRNA-LNPs: Decoupling Tumor and Liver Biodistribution in Pancreatic Cancer.
3115,7547,41889911,10.64898/2026.03.20.712457,toxicity,ASO/siRNA,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Structure-Activity Mapping of Intraperitoneal mRNA-LNPs: Decoupling Tumor and Liver Biodistribution in Pancreatic Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Structure-Activity Mapping of Intraperitoneal mRNA-LNPs: Decoupling Tumor and Liver Biodistribution in Pancreatic Cancer.
3124,7572,41832734,10.2174/0113895575428832251206055438,chemistry,ASO,PubMed abstract sentence 6,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Antisense Molecules: Design, Chemistry, and Therapeutic Innovations.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Antisense Molecules: Design, Chemistry, and Therapeutic Innovations."
3129,7585,41828464,10.3390/ijms27052239,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Investigation of Heterogeneity of Lipid Nanoparticles for Nucleic Acid Drug Delivery via Sucrose Gradient Density Centrifugation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Investigation of Heterogeneity of Lipid Nanoparticles for Nucleic Acid Drug Delivery via Sucrose Gradient Density Centrifugation.
3132,7592,41815890,10.1016/j.omtn.2026.102866,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Optimizing C14120-based LNPs for in vitro and in vivo mRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimizing C14120-based LNPs for in vitro and in vivo mRNA delivery.
3136,7600,41810471,10.1016/j.ajps.2026.101119,delivery,siRNA,PubMed abstract sentence 5,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Advances in nano-delivery systems for overcoming the challenges of applying siRNA drugs in tumor therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in nano-delivery systems for overcoming the challenges of applying siRNA drugs in tumor therapy.
3140,7608,41803280,10.1038/s41596-025-01330-w,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, uptake; source title: Preparation of targeted lipid nanoparticles for precision nucleic acid delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preparation of targeted lipid nanoparticles for precision nucleic acid delivery.
3142,7612,41791459,10.1016/j.jconrel.2026.114783,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Oscillation-generating micromixing (FDmiX) - a new method for manufacturing of mRNA-lipid nanoparticles with scalable high-throughput production.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oscillation-generating micromixing (FDmiX) - a new method for manufacturing of mRNA-lipid nanoparticles with scalable high-throughput production.
3147,7627,41767047,10.3389/fmolb.2026.1767656,delivery,ASO,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: ATP-sensitive peptide-based coacervates for intracellular delivery of therapeutic oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,ATP-sensitive peptide-based coacervates for intracellular delivery of therapeutic oligonucleotides.
3148,7628,41767047,10.3389/fmolb.2026.1767656,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ATP-sensitive peptide-based coacervates for intracellular delivery of therapeutic oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ATP-sensitive peptide-based coacervates for intracellular delivery of therapeutic oligonucleotides.
3150,7634,41761629,10.1080/10717544.2026.2637266,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells.
3152,7638,41761431,10.1002/wnan.70053,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Drug Product Development of Lipid Nanoparticle-Based mRNA Therapeutics and Vaccines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Drug Product Development of Lipid Nanoparticle-Based mRNA Therapeutics and Vaccines.
3159,7655,41754897,10.3390/pharmaceutics18020154,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery of siRNA and Chloroquine Through an Aspherical, Nanostructured Microparticle for Passive Targeting of Alveolar Macrophages and Inhibition of Local TNF-α Secretion.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Delivery of siRNA and Chloroquine Through an Aspherical, Nanostructured Microparticle for Passive Targeting of Alveolar Macrophages and Inhibition of Local TNF-α Secretion."
3162,7668,41737296,10.1039/d5pm00379b,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: QbD product development: rapid optimization and scale-up of PBAE-based siRNA delivery via DoE-guided microfluidics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,QbD product development: rapid optimization and scale-up of PBAE-based siRNA delivery via DoE-guided microfluidics.
3167,7685,41711348,10.1021/jacs.5c16025,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Structural Change of ApoE-Lipid Nanoparticles Alters Receptor-Mediated Endocytosis and Induces Endosomal Disruption.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structural Change of ApoE-Lipid Nanoparticles Alters Receptor-Mediated Endocytosis and Induces Endosomal Disruption.
3172,7694,41708844,10.1208/s12249-025-03323-0,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: The PAH-AM-PEG-ApoE@siRNA Nanocarrier Delivery System for Polo-like Kinase 1 Inhibition Suppresses Glioma Progression.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The PAH-AM-PEG-ApoE@siRNA Nanocarrier Delivery System for Polo-like Kinase 1 Inhibition Suppresses Glioma Progression.
3176,7706,41704233,10.1016/j.bioactmat.2026.02.006,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Polyplex of peptide-mannan and RNA for intranasal delivery of TGF-β siRNA in treatment of pulmonary fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Polyplex of peptide-mannan and RNA for intranasal delivery of TGF-β siRNA in treatment of pulmonary fibrosis.
3180,7714,41691524,10.1021/acsnano.5c19036,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Comprehensive Engineering of Ionizable Lipid Nanoparticles and mRNA Elements for Next-Generation Vaccines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comprehensive Engineering of Ionizable Lipid Nanoparticles and mRNA Elements for Next-Generation Vaccines.
3186,7734,41672452,10.1021/acs.nanolett.5c05535,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Toward In Vivo CAR T Cell Therapy: Perfecting CAR and Lipid Nanoparticle Design.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Toward In Vivo CAR T Cell Therapy: Perfecting CAR and Lipid Nanoparticle Design.
3188,7738,41664462,10.1021/acsami.5c12952,toxicity,siRNA,PubMed abstract sentence 9,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: Hemocompatibility of Carbosilane Dendrimers as a Therapeutic siRNA Delivery System across Blood-Brain Barrier.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hemocompatibility of Carbosilane Dendrimers as a Therapeutic siRNA Delivery System across Blood-Brain Barrier.
3193,7749,41648519,10.64898/2026.01.16.699683,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Structural heterogeneity in mRNA-LNP subpopulations revealed by AF4-SAXS: implications for cargo loading and cell transfection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structural heterogeneity in mRNA-LNP subpopulations revealed by AF4-SAXS: implications for cargo loading and cell transfection.
3194,7752,41647289,10.1093/rb/rbaf115,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A smart nanocomposite bioactive ink for controlled siRNA delivery in calvarial mesenchymal stromal cells as a minimally invasive treatment for craniosynostosis.",C,high_candidate,curator_verified,accept,derived_annotations_only,A smart nanocomposite bioactive ink for controlled siRNA delivery in calvarial mesenchymal stromal cells as a minimally invasive treatment for craniosynostosis.
3205,7781,41605132,10.1021/acsnano.5c21787,delivery,ASO,PubMed abstract sentence 6,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Enhanced Delivery of Lipid Nanoparticle-Based Immunotherapy by Modulating the Tumor Tissue Stiffness Using Ultrasound-Activated Nanobubbles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced Delivery of Lipid Nanoparticle-Based Immunotherapy by Modulating the Tumor Tissue Stiffness Using Ultrasound-Activated Nanobubbles.
3209,7795,41582851,10.1039/d5bm01643f,delivery,siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Glutathione-activatable bola dendrimers mediate tumor-specific cytosolic siRNA delivery via dynamic thiol-disulfide exchange.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Glutathione-activatable bola dendrimers mediate tumor-specific cytosolic siRNA delivery via dynamic thiol-disulfide exchange.
3210,7796,41582851,10.1039/d5bm01643f,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Glutathione-activatable bola dendrimers mediate tumor-specific cytosolic siRNA delivery via dynamic thiol-disulfide exchange.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Glutathione-activatable bola dendrimers mediate tumor-specific cytosolic siRNA delivery via dynamic thiol-disulfide exchange.
3211,7799,41581469,10.1016/j.compbiomed.2026.111479,delivery,ASO,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Peptide-nanoparticle platforms for antisense therapeutics: A coarse-grained modeling approach to brain delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Peptide-nanoparticle platforms for antisense therapeutics: A coarse-grained modeling approach to brain delivery.
3212,7800,41581469,10.1016/j.compbiomed.2026.111479,assay,ASO,PubMed abstract sentence 5,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Peptide-nanoparticle platforms for antisense therapeutics: A coarse-grained modeling approach to brain delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Peptide-nanoparticle platforms for antisense therapeutics: A coarse-grained modeling approach to brain delivery.
3215,7807,41572459,10.1002/adhm.202504773,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: siRNA Delivery via Cross-Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic-Vascular Cross-Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA Delivery via Cross-Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic-Vascular Cross-Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA.
3217,7811,41572432,10.1002/advs.202510547,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites.
3220,7818,41561442,10.1093/narcan/zcag002,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification of siRNA silencing TGFβ1 and VEGFR2 and utility of the combination in targeting immune modulation and angiogenesis in treating melanoma in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identification of siRNA silencing TGFβ1 and VEGFR2 and utility of the combination in targeting immune modulation and angiogenesis in treating melanoma in vivo.
3223,7823,41560836,10.1016/j.mtbio.2026.102764,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;conjugated,"delivery candidate; matched derived terms: delivery, nanoparticle, conjugated; source title: Intranasal delivery of Odorranalectin-modified lipid nanoparticles for multi-targeted therapy of Alzheimer's disease.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intranasal delivery of Odorranalectin-modified lipid nanoparticles for multi-targeted therapy of Alzheimer's disease.
3228,7834,41553231,10.1039/d5bm01235j,delivery,siRNA,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: A pH-ultrasensitive membranolytic polymer-assisted delivery system for enhanced siRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A pH-ultrasensitive membranolytic polymer-assisted delivery system for enhanced siRNA delivery.
3232,7842,41549563,10.1002/bab.70123,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pseudomonas aeruginosa Peptide From Strain P3 (PAP3) and AKT Serine/Threonine Kinase 1 (AKT1) siRNA-Loaded Chitosan Nanoparticle as a Co-Delivery System for Enhanced Anticancer Activity in Lung Cancer Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pseudomonas aeruginosa Peptide From Strain P3 (PAP3) and AKT Serine/Threonine Kinase 1 (AKT1) siRNA-Loaded Chitosan Nanoparticle as a Co-Delivery System for Enhanced Anticancer Activity in Lung Cancer Cells.
3243,7865,41532161,10.1002/smll.202511807,delivery,siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Arginine Polymerization Boosts Anti-Inflammatory Effects and DNA Nanostructure-Assisted siRNA Delivery in Acute Respiratory Distress Syndrome.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Arginine Polymerization Boosts Anti-Inflammatory Effects and DNA Nanostructure-Assisted siRNA Delivery in Acute Respiratory Distress Syndrome.
3245,7869,41530849,10.1186/s12943-025-02525-1,delivery,siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: CircROR1 binds HNRNPL to regulate FOXO4 pre-mRNA splicing, promoting cutaneous melanoma metastasis and serving as a therapeutic target via RNAi-loaded PEG-LNPs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"CircROR1 binds HNRNPL to regulate FOXO4 pre-mRNA splicing, promoting cutaneous melanoma metastasis and serving as a therapeutic target via RNAi-loaded PEG-LNPs."
3249,7879,41518301,10.1021/acs.bioconjchem.5c00554,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ""Zip-to-Cytosol"": Glutathione-Cleavable Fluorinated Polyplexes Deliver siRNA at Single-Digit Nanomolar Dose with >90% Gene Silencing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"""Zip-to-Cytosol"": Glutathione-Cleavable Fluorinated Polyplexes Deliver siRNA at Single-Digit Nanomolar Dose with >90% Gene Silencing."
3272,7934,41479120,10.1007/978-3-032-06948-1_12,assay,ASO/siRNA,PubMed abstract sentence 5,model;trial,"assay candidate; matched derived terms: model, trial; source title: Noncoding RNA in Clinical Trials: Diagnostic and Therapeutical Prospects.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Noncoding RNA in Clinical Trials: Diagnostic and Therapeutical Prospects.
3274,7940,41477663,10.1016/j.bioactmat.2025.11.049,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chiral metal nanozyme-enabled SOD2 activation and siRNA delivery cooperatively mitigating chronic heart failure.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chiral metal nanozyme-enabled SOD2 activation and siRNA delivery cooperatively mitigating chronic heart failure.
3276,7950,41437655,10.1002/adhm.202504363,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Rational Design of pH-Switchable 3α-Amino Lithocholate-Modified Lipids for Efficient siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rational Design of pH-Switchable 3α-Amino Lithocholate-Modified Lipids for Efficient siRNA Delivery.
3279,7961,41418366,10.1016/j.colsurfb.2025.115352,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Pullulan-based polymeric nanosystem for KEAP1 siRNA delivery: Mitigating ROS and promoting wound healing in vitro.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pullulan-based polymeric nanosystem for KEAP1 siRNA delivery: Mitigating ROS and promoting wound healing in vitro.
3283,7969,41391722,10.1016/j.jconrel.2025.114539,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Understanding excipient interactions unlocks untapped potential of RNA-lipid nanoparticles in dry powder formulations for local pulmonary delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Understanding excipient interactions unlocks untapped potential of RNA-lipid nanoparticles in dry powder formulations for local pulmonary delivery.
3285,7979,41371503,10.1016/j.jconrel.2025.114519,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Pulmonary macrophage-targeted RNAi and mRNA co-delivery via SORT lipid nanoparticles enhances immunotherapy in lung cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pulmonary macrophage-targeted RNAi and mRNA co-delivery via SORT lipid nanoparticles enhances immunotherapy in lung cancer.
3290,7994,41351306,10.1080/17435889.2025.2598337,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Emerging nanotechnology-enabled siRNA oral delivery platforms.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Emerging nanotechnology-enabled siRNA oral delivery platforms.
3295,8005,41330517,10.1016/j.jconrel.2025.114487,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Ionic liquid-coated lipid nanoparticles demonstrate prolonged circulation and brain uptake via red blood cell hitchhiking.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ionic liquid-coated lipid nanoparticles demonstrate prolonged circulation and brain uptake via red blood cell hitchhiking.
3298,8010,41330499,10.1016/j.ijbiomac.2025.149378,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineered peptide-oligonucleotide composite nanotubes for redox-triggered drug delivery in cellular and pre-clinical glioma models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineered peptide-oligonucleotide composite nanotubes for redox-triggered drug delivery in cellular and pre-clinical glioma models.
3300,8014,41319500,10.1016/j.carres.2025.109779,delivery,siRNA,PubMed abstract sentence 2,uptake;route,"delivery candidate; matched derived terms: uptake, route; source title: A comprehensive review on marine algal polysaccharide-mediated siRNA delivery systems for biofuel production.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A comprehensive review on marine algal polysaccharide-mediated siRNA delivery systems for biofuel production.
3305,8023,41316820,10.1002/adma.202517893,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: nanoparticle, lnp, uptake; source title: Potent Liver-Tropic mRNA Lipid Nanoparticles: ApoE-Mediated Delivery Through a Low-Density Lipoprotein Receptor Independent Uptake Mechanism.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Potent Liver-Tropic mRNA Lipid Nanoparticles: ApoE-Mediated Delivery Through a Low-Density Lipoprotein Receptor Independent Uptake Mechanism.
3306,8024,41316820,10.1002/adma.202517893,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Potent Liver-Tropic mRNA Lipid Nanoparticles: ApoE-Mediated Delivery Through a Low-Density Lipoprotein Receptor Independent Uptake Mechanism.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Potent Liver-Tropic mRNA Lipid Nanoparticles: ApoE-Mediated Delivery Through a Low-Density Lipoprotein Receptor Independent Uptake Mechanism.
3312,8038,41265762,10.1016/j.ejps.2025.107383,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Impact of formulation and process parameters on the stability and bioactivity of RNA-loaded lipid nanoparticles during nebulization.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Impact of formulation and process parameters on the stability and bioactivity of RNA-loaded lipid nanoparticles during nebulization.
3313,8041,41265757,10.1016/j.pharmthera.2025.108960,delivery,ASO,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Next-generation nanocarriers for therapeutic oligonucleotides: Precision targeting and stimuli-responsive cancer therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Next-generation nanocarriers for therapeutic oligonucleotides: Precision targeting and stimuli-responsive cancer therapy.
3317,8051,41252931,10.1016/j.bios.2025.118226,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Stability-preserving post-processing of mRNA-lipid nanoparticles utilizing a scalable ion concentration polarization platform.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Stability-preserving post-processing of mRNA-lipid nanoparticles utilizing a scalable ion concentration polarization platform.
3321,8061,41246913,10.1080/17435889.2025.2587715,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Advancing RNA delivery with Ionizable lipid nanoparticles: the roles of microfluidics and machine learning.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advancing RNA delivery with Ionizable lipid nanoparticles: the roles of microfluidics and machine learning.
3332,8086,41147388,10.1002/advs.202511222,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Unique Aerofoil-Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale-up.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unique Aerofoil-Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale-up.
3334,8090,41116066,10.1007/s13346-025-01987-6,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Strategic lipid nanoparticle design dictates retinal delivery post inner limiting membrane disruption.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Strategic lipid nanoparticle design dictates retinal delivery post inner limiting membrane disruption.
3336,8094,41076799,10.1016/j.bioadv.2025.214537,delivery,siRNA,PubMed abstract sentence 1,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Novel vector for efficient siRNA delivery to lymphoblasts and melanoma based on genipin-spermine nanocarriers protected with hybrid erythrocyte membrane coating.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel vector for efficient siRNA delivery to lymphoblasts and melanoma based on genipin-spermine nanocarriers protected with hybrid erythrocyte membrane coating.
3337,8095,41076799,10.1016/j.bioadv.2025.214537,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Novel vector for efficient siRNA delivery to lymphoblasts and melanoma based on genipin-spermine nanocarriers protected with hybrid erythrocyte membrane coating.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Novel vector for efficient siRNA delivery to lymphoblasts and melanoma based on genipin-spermine nanocarriers protected with hybrid erythrocyte membrane coating.
3341,8105,41046080,10.1016/j.ejps.2025.107308,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ASGPR-targeted micelles co-delivering lenvatinib and COP1 siRNA for hepatocellular carcinoma via dual-targeting.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ASGPR-targeted micelles co-delivering lenvatinib and COP1 siRNA for hepatocellular carcinoma via dual-targeting.
3343,8111,40940519,10.1007/s00216-025-06096-4,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Challenges and advances in analytical separation techniques for RNA-lipid nanoparticle therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Challenges and advances in analytical separation techniques for RNA-lipid nanoparticle therapeutics.
3344,8116,40882417,10.1016/j.talanta.2025.128754,chemistry,ASO,PubMed abstract sentence 6,chemical;modification;modified,"chemistry candidate; matched derived terms: chemical, modification, modified; source title: Oligonucleotide-immobilized PEGylated black phosphorene with enhanced stability and activity for electrochemical detection of trace uranyl.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oligonucleotide-immobilized PEGylated black phosphorene with enhanced stability and activity for electrochemical detection of trace uranyl.
3345,8119,40838609,10.1080/1061186X.2025.2550594,delivery,ASO,PubMed abstract sentence 6,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Targeted delivery of anti-microRNA-21 oligonucleotides using chlorotoxin-engineered extracellular vesicles for treatment of glioblastoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted delivery of anti-microRNA-21 oligonucleotides using chlorotoxin-engineered extracellular vesicles for treatment of glioblastoma.
3347,8125,40770585,10.1007/s13346-025-01936-3,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Targeted oral delivery of microencapsulated TNF-α siRNA in an experimental model of colitis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted oral delivery of microencapsulated TNF-α siRNA in an experimental model of colitis.
3354,8140,40266550,10.1007/s13346-025-01860-6,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Development of silver-based hybrid nanoparticles loaded with eEF2 K-siRNA and quercetin against triple-negative breast cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of silver-based hybrid nanoparticles loaded with eEF2 K-siRNA and quercetin against triple-negative breast cancer.
3360,8158,41625362,10.1016/j.mtbio.2025.102267,delivery,siRNA,PubMed abstract sentence 6,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Tumor-homing exosomes enable targeted delivery of siRNA and isoimperatorin for overcoming BTK inhibitor resistance in DLBCL.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tumor-homing exosomes enable targeted delivery of siRNA and isoimperatorin for overcoming BTK inhibitor resistance in DLBCL.
3366,8172,41487160,10.1021/acsomega.5c08046,delivery,siRNA,PubMed abstract sentence 1,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Ligand Valency and Linker Design Dictate the Efficacy of CI-M6PR-Mediated Targeted Delivery of M6P-siRNA Conjugates.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ligand Valency and Linker Design Dictate the Efficacy of CI-M6PR-Mediated Targeted Delivery of M6P-siRNA Conjugates.
3369,8179,41473322,10.64898/2025.12.16.694641,delivery,siRNA,PubMed abstract sentence 5,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system.
3371,8183,41471333,10.3390/ph18121844,delivery,siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Development of a Dual Gene-Targeted Multi-Sirna with Branched Structure and Its Role in the Therapy of Liver Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of a Dual Gene-Targeted Multi-Sirna with Branched Structure and Its Role in the Therapy of Liver Cancer.
3372,8184,41471333,10.3390/ph18121844,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of a Dual Gene-Targeted Multi-Sirna with Branched Structure and Its Role in the Therapy of Liver Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of a Dual Gene-Targeted Multi-Sirna with Branched Structure and Its Role in the Therapy of Liver Cancer.
3376,8194,41438365,10.1016/j.omtn.2025.102776,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The role of exosomes as oligonucleotide delivery system for managing α-synuclein in Parkinson's disease: A systematic review of in vivo studies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The role of exosomes as oligonucleotide delivery system for managing α-synuclein in Parkinson's disease: A systematic review of in vivo studies.
3378,8200,41430089,10.1038/s41598-025-32407-x,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Delivery of lipid nanoparticles containing small interfering RNA targeting transmembrane serine protease 4 in a human gastric cancer model using nude mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of lipid nanoparticles containing small interfering RNA targeting transmembrane serine protease 4 in a human gastric cancer model using nude mice.
3386,8214,41419756,10.1038/s41597-025-06456-w,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A Comprehensive Dataset of Lipid Nanoparticle Compositions and Properties for Nucleic Acid Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Comprehensive Dataset of Lipid Nanoparticle Compositions and Properties for Nucleic Acid Delivery.
3389,8223,41399806,10.1016/j.omtn.2025.102773,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Myeloid cell-targeted lipid nanoparticles for B cell lymphoma immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Myeloid cell-targeted lipid nanoparticles for B cell lymphoma immunotherapy.
3393,8239,41378821,10.1021/acsnano.5c16991,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Optimizing Exosome Lipid Hybrid Nanoparticles for Enhanced siRNA Delivery and Improved Therapeutic Anticancer Efficacy In Vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimizing Exosome Lipid Hybrid Nanoparticles for Enhanced siRNA Delivery and Improved Therapeutic Anticancer Efficacy In Vivo.
3398,8248,41361792,10.1186/s12951-025-03827-8,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synergistic effect study on the co-delivery of paclitaxel and SiRNA targeting STMN1 based on MPDA nanoparticles in the therapy of ovarian cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synergistic effect study on the co-delivery of paclitaxel and SiRNA targeting STMN1 based on MPDA nanoparticles in the therapy of ovarian cancer.
3402,8262,41304744,10.3390/pharmaceutics17111407,delivery,siRNA,PubMed abstract sentence 2,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Research Progress on Nasal Delivery of siRNA Nanocarrier Systems for the Treatment of Neurodegenerative Diseases.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Research Progress on Nasal Delivery of siRNA Nanocarrier Systems for the Treatment of Neurodegenerative Diseases.
3407,8269,41299672,10.1186/s12951-025-03872-3,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Peptide-modified phase-transition nanoparticles co-deliver FTO siRNA and Ce6 for sonodynamic metabolism-immunotherapy of melanoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Peptide-modified phase-transition nanoparticles co-deliver FTO siRNA and Ce6 for sonodynamic metabolism-immunotherapy of melanoma.
3411,8279,41277575,10.1039/d5tb01908g,delivery,siRNA,PubMed abstract sentence 1,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Photoactivated bioinspired lipoplexes with a chalcone/flavylium photoswitch enhance siRNA delivery-towards precise spatiotemporal control in gene delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Photoactivated bioinspired lipoplexes with a chalcone/flavylium photoswitch enhance siRNA delivery-towards precise spatiotemporal control in gene delivery.
3412,8280,41277575,10.1039/d5tb01908g,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Photoactivated bioinspired lipoplexes with a chalcone/flavylium photoswitch enhance siRNA delivery-towards precise spatiotemporal control in gene delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Photoactivated bioinspired lipoplexes with a chalcone/flavylium photoswitch enhance siRNA delivery-towards precise spatiotemporal control in gene delivery.
3414,8286,41264094,10.1007/s13402-025-01104-2,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Tumor-homing nanoplatform for the co-delivery of triptolide and siRNA-A4B2 conspicuously overcomes peritoneum metastasis of ovarian cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Tumor-homing nanoplatform for the co-delivery of triptolide and siRNA-A4B2 conspicuously overcomes peritoneum metastasis of ovarian cancer.
3418,8298,41241375,10.1016/j.drudis.2025.104543,delivery,siRNA,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: siRNA-based Nanocarriers for Targeted Therapy in Prostate Cancer: Implications for Male Fertility Preservation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA-based Nanocarriers for Targeted Therapy in Prostate Cancer: Implications for Male Fertility Preservation.
3419,8307,41210824,10.1021/acsomega.5c09358,chemistry,siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Model-Assisted Process Optimization for Trivalent Ligand-siRNA Conjugation via CuAAC Click Chemistry.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Model-Assisted Process Optimization for Trivalent Ligand-siRNA Conjugation via CuAAC Click Chemistry.
3420,8308,41210824,10.1021/acsomega.5c09358,assay,siRNA,PubMed abstract sentence 5,screen;experiment,"assay candidate; matched derived terms: screen, experiment; source title: Model-Assisted Process Optimization for Trivalent Ligand-siRNA Conjugation via CuAAC Click Chemistry.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Model-Assisted Process Optimization for Trivalent Ligand-siRNA Conjugation via CuAAC Click Chemistry.
3422,8312,41210516,10.2147/JEP.S546622,assay,siRNA,PubMed abstract sentence 9,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: In vivo Therapeutic Inhibition of the Tp53-Induced Glycolysis and Apoptosis Regulator (TIGAR) by Intravenous Administration of an Anti-Oncological siRNA-Biopolymer, TI6752 (Tituxistatin), in a Preclinical Xenograft Model of Colorectal Cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"In vivo Therapeutic Inhibition of the Tp53-Induced Glycolysis and Apoptosis Regulator (TIGAR) by Intravenous Administration of an Anti-Oncological siRNA-Biopolymer, TI6752 (Tituxistatin), in a Preclinical Xenograft Model of Colorectal Cancer."
3424,8316,41210170,10.1016/j.omtm.2025.101609,chemistry,siRNA,PubMed abstract sentence 2,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Design and systematic evaluation of novel chemical modification patterns enable the identification of a potent siRNA targeting PCSK9.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Design and systematic evaluation of novel chemical modification patterns enable the identification of a potent siRNA targeting PCSK9.
3425,8319,41201040,10.1021/acsmacrolett.5c00453,delivery,siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Bioreducible Targeted Module and Chlorogenic Acid Functionalized Polycations as Efficient and Selective siRNA Vectors for Cancer Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Bioreducible Targeted Module and Chlorogenic Acid Functionalized Polycations as Efficient and Selective siRNA Vectors for Cancer Cells.
3428,8326,41186073,10.1080/17435889.2025.2574249,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoemulsions as carriers for malignant brain tumors treatment: a scoping review on drugs, natural compounds, and siRNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Nanoemulsions as carriers for malignant brain tumors treatment: a scoping review on drugs, natural compounds, and siRNA delivery."
3429,8329,41183985,10.1248/cpb.c25-00477,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: NMR-Based Molecular-Level Characterization: A Review of Its Application in Unveiling Lipid Nanoparticle Formulations.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,NMR-Based Molecular-Level Characterization: A Review of Its Application in Unveiling Lipid Nanoparticle Formulations.
3430,8332,41177462,10.1016/j.jconrel.2025.114373,delivery,siRNA,PubMed abstract sentence 2,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Nasal-to-brain siRNA delivery based on trace amine associated receptor for improving cognitive function.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nasal-to-brain siRNA delivery based on trace amine associated receptor for improving cognitive function.
3432,8342,41165149,10.1039/d5nr02667a,delivery,siRNA,PubMed abstract sentence 5,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Surface-engineered gold nanorods for targeted delivery of PD-L1 siRNA and cancer chemo-phototherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Surface-engineered gold nanorods for targeted delivery of PD-L1 siRNA and cancer chemo-phototherapy.
3433,8343,41165149,10.1039/d5nr02667a,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Surface-engineered gold nanorods for targeted delivery of PD-L1 siRNA and cancer chemo-phototherapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Surface-engineered gold nanorods for targeted delivery of PD-L1 siRNA and cancer chemo-phototherapy.
3434,8346,41163434,10.1021/acs.molpharmaceut.5c00614,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: The Use of Enhanced Analytical Pipelines for the Characterization of Poly(A) and Poly(A)-LNP Formulation Critical Quality Attributes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Use of Enhanced Analytical Pipelines for the Characterization of Poly(A) and Poly(A)-LNP Formulation Critical Quality Attributes.
3436,8350,41161496,10.1016/j.jconrel.2025.114362,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Non-cationic carriers for siRNA delivery: Current progress and potential applications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Non-cationic carriers for siRNA delivery: Current progress and potential applications.
3437,8355,41155946,10.3390/pharmaceutics17101309,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Physiological Barriers to Nucleic Acid Therapeutics and Engineering Strategies for Lipid Nanoparticle Design, Optimization, and Clinical Translation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Physiological Barriers to Nucleic Acid Therapeutics and Engineering Strategies for Lipid Nanoparticle Design, Optimization, and Clinical Translation."
3439,8359,41155238,10.3390/ijms26209944,offtarget,ASO/siRNA,PubMed abstract sentence 5,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: RNA Interference-Mediated Silencing of HbREF and HbSRPP Genes Reduces Allergenic Protein Content While Maintaining Rubber Production in Hevea brasiliensis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA Interference-Mediated Silencing of HbREF and HbSRPP Genes Reduces Allergenic Protein Content While Maintaining Rubber Production in Hevea brasiliensis.
3441,8369,41141640,10.21769/BioProtoc.5475,offtarget,siRNA,PubMed abstract sentence 6,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Effective Gene Silencing in Plants by Synthetic Trans-Acting siRNAs Derived From Minimal Precursors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Effective Gene Silencing in Plants by Synthetic Trans-Acting siRNAs Derived From Minimal Precursors.
3442,8374,41134881,10.1126/sciadv.adx5970,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Ionizable guanidine-based lipid nanoparticle for targeted mRNA delivery and cancer immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ionizable guanidine-based lipid nanoparticle for targeted mRNA delivery and cancer immunotherapy.
3446,8382,41132742,10.1039/d5ra05353f,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Influence of polyethylene glycol on the mucus penetration and stability of lipid nanoparticles in cryopreservation and lyophilization.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Influence of polyethylene glycol on the mucus penetration and stability of lipid nanoparticles in cryopreservation and lyophilization.
3452,8396,41110473,10.1016/j.jconrel.2025.114315,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Topical mutant allele-specific siRNA delivery for treatment of Meesmann epithelial corneal dystrophy and elucidation of disease biomarkers.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Topical mutant allele-specific siRNA delivery for treatment of Meesmann epithelial corneal dystrophy and elucidation of disease biomarkers.
3456,8406,41096791,10.3390/ijms26199526,chemistry,ASO,PubMed abstract sentence 5,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Targeting carA Using Optimized Antisense Peptide Nucleic Acid-Cell-Penetrating Peptide Conjugates in Acinetobacter baumannii: A Novel Antibacterial Approach.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting carA Using Optimized Antisense Peptide Nucleic Acid-Cell-Penetrating Peptide Conjugates in Acinetobacter baumannii: A Novel Antibacterial Approach.
3460,8414,41080733,10.1016/j.mtbio.2025.102321,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Cholesterol modified defense peptide as an EMP2-siRNA delivery system for synergistic immunogene therapy against breast cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cholesterol modified defense peptide as an EMP2-siRNA delivery system for synergistic immunogene therapy against breast cancer.
3462,8420,41070092,10.3389/fcvm.2025.1561917,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: The evolving landscape of restrictive cardiomyopathy treatment: clinical trial trends and future directions.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The evolving landscape of restrictive cardiomyopathy treatment: clinical trial trends and future directions.
3463,8423,41065015,10.1080/17435889.2025.2567842,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Breakthroughs in the nanoparticle-mediated delivery of siRNA for breast cancer treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Breakthroughs in the nanoparticle-mediated delivery of siRNA for breast cancer treatment.
3466,8430,41060394,10.1021/acs.accounts.5c00522,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Ionizable Lipid Nanoparticles for mRNA Delivery: Internal Self-Assembled Inverse Mesophase Structure and Endosomal Escape.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ionizable Lipid Nanoparticles for mRNA Delivery: Internal Self-Assembled Inverse Mesophase Structure and Endosomal Escape.
3473,8445,41045966,10.1016/j.jconrel.2025.114286,delivery,siRNA,PubMed abstract sentence 6,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Lipid and polymeric nanocarriers for siRNA delivery to the brain.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid and polymeric nanocarriers for siRNA delivery to the brain.
3476,8450,41037472,10.1021/acsabm.5c01486,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Peptide-Functionalized Selenium Nanoparticle-Based Effective Delivery System for Src-Targeting siRNA in Triple-Negative Breast Cancer Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Peptide-Functionalized Selenium Nanoparticle-Based Effective Delivery System for Src-Targeting siRNA in Triple-Negative Breast Cancer Cells.
3482,8468,41014631,10.1021/acs.molpharmaceut.5c00715,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted Delivery of Anti-TGF-β(1)-siRNA Using PDGFR-β Peptide-Modified Chitosan Nanoparticles for the Treatment of Liver Fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted Delivery of Anti-TGF-β(1)-siRNA Using PDGFR-β Peptide-Modified Chitosan Nanoparticles for the Treatment of Liver Fibrosis.
3483,8469,41014631,10.1021/acs.molpharmaceut.5c00715,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted Delivery of Anti-TGF-β(1)-siRNA Using PDGFR-β Peptide-Modified Chitosan Nanoparticles for the Treatment of Liver Fibrosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted Delivery of Anti-TGF-β(1)-siRNA Using PDGFR-β Peptide-Modified Chitosan Nanoparticles for the Treatment of Liver Fibrosis.
3486,8478,41007671,10.3390/biomedicines13092108,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic;dna damage,"toxicity candidate; matched derived terms: toxicity, toxic, dna damage; source title: Crossing Barriers: PEGylated Gold Nanoparticles as Promising Delivery Vehicles for siRNA Delivery in Alzheimer's Disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Crossing Barriers: PEGylated Gold Nanoparticles as Promising Delivery Vehicles for siRNA Delivery in Alzheimer's Disease.
3488,8490,40988620,10.1002/smll.202506812,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Recent Advances in Lipid Nanoparticles: Nucleic Acid Therapeutics and Targeting Strategies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent Advances in Lipid Nanoparticles: Nucleic Acid Therapeutics and Targeting Strategies.
3489,8495,40978531,10.1016/j.omtn.2025.102671,delivery,siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Nose-to-brain siRNA delivery by PEI/PPI-based nanoparticles reduces α-synuclein expression in a Parkinson's disease mouse model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nose-to-brain siRNA delivery by PEI/PPI-based nanoparticles reduces α-synuclein expression in a Parkinson's disease mouse model.
3491,8497,40978531,10.1016/j.omtn.2025.102671,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nose-to-brain siRNA delivery by PEI/PPI-based nanoparticles reduces α-synuclein expression in a Parkinson's disease mouse model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Nose-to-brain siRNA delivery by PEI/PPI-based nanoparticles reduces α-synuclein expression in a Parkinson's disease mouse model.
3497,8509,40964976,10.1080/07357907.2025.2559088,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Recent Advances in Nanocarrier Systems for the Co-Delivery of siRNA and Chemotherapeutic Drug for Breast Cancer Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Recent Advances in Nanocarrier Systems for the Co-Delivery of siRNA and Chemotherapeutic Drug for Breast Cancer Therapy.
3498,8512,40964266,10.1101/2025.09.03.674081,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Crosslinking of Lipid Nanoparticles Enhances the Delivery Efficiency and Efficacy of mRNA Vaccines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Crosslinking of Lipid Nanoparticles Enhances the Delivery Efficiency and Efficacy of mRNA Vaccines.
3500,8516,40947594,10.1021/jacs.5c08376,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Strain-Promoted mRNA Transdermal Delivery by Lipoic Lipid Nanoparticles for Therapeutic Skin Genome Editing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Strain-Promoted mRNA Transdermal Delivery by Lipoic Lipid Nanoparticles for Therapeutic Skin Genome Editing.
3506,8532,40943370,10.3390/ijms26178448,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhancing Antitumor Efficacy of MUC1 mRNA Nano-Vaccine by CTLA-4 siRNA-Mediated Immune Checkpoint Modulation in Triple Negative Breast Cancer Mice Model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhancing Antitumor Efficacy of MUC1 mRNA Nano-Vaccine by CTLA-4 siRNA-Mediated Immune Checkpoint Modulation in Triple Negative Breast Cancer Mice Model.
3508,8536,40942197,10.3390/polym17172279,delivery,siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Research Progress on Polymer-Based Nanocarriers for Tumor-Targeted Delivery of Survivin siRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Research Progress on Polymer-Based Nanocarriers for Tumor-Targeted Delivery of Survivin siRNA.
3510,8540,40939831,10.1016/j.jinsphys.2025.104884,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, uptake; source title: Recent progress in nanoparticle-mediated RNA interference in insects: Unveiling new frontiers in pest control.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent progress in nanoparticle-mediated RNA interference in insects: Unveiling new frontiers in pest control.
3512,8544,40939253,10.1016/j.bmc.2025.118383,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Redox-cleavable disulfide linker enhances siRNA delivery by prodrug-type bifunctional cell-penetrating peptide.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Redox-cleavable disulfide linker enhances siRNA delivery by prodrug-type bifunctional cell-penetrating peptide.
3514,8548,40929797,10.1016/j.bioorg.2025.108945,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Triaminophenaziniums as emerging theranostic agents showing light controlled imaging, cell death and siRNA delivery properties.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Triaminophenaziniums as emerging theranostic agents showing light controlled imaging, cell death and siRNA delivery properties."
3516,8554,40921290,10.1016/j.ijpharm.2025.126156,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Liver-targeted siRNA delivery via artificial red blood cells to lower LDL-C.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Liver-targeted siRNA delivery via artificial red blood cells to lower LDL-C.
3517,8555,40921290,10.1016/j.ijpharm.2025.126156,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Liver-targeted siRNA delivery via artificial red blood cells to lower LDL-C.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Liver-targeted siRNA delivery via artificial red blood cells to lower LDL-C.
3519,8559,40919077,10.1016/j.jhepr.2025.101516,toxicity,siRNA,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: The phase II PENGUIN study.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: The phase II PENGUIN study.
3520,8562,40918946,10.2147/IJN.S532246,delivery,siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Advances in Lipid-Based Nanomedicine: Pathway Specific siRNA Therapy and Optimizing Delivery for Hepatocellular Carcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in Lipid-Based Nanomedicine: Pathway Specific siRNA Therapy and Optimizing Delivery for Hepatocellular Carcinoma.
3523,8567,40917895,10.1016/j.omtn.2025.102685,delivery,ASO,PubMed abstract sentence 4,conjugated;uptake,"delivery candidate; matched derived terms: conjugated, uptake; source title: Molecular properties and intramolecular interactions of peptide-conjugated phosphorodiamidate morpholino oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Molecular properties and intramolecular interactions of peptide-conjugated phosphorodiamidate morpholino oligonucleotides.
3525,8573,40915857,10.1002/psc.70054,delivery,siRNA,PubMed abstract sentence 5,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Amphipathic Octenyl-Alanine Modified Peptides Mediate Effective siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Amphipathic Octenyl-Alanine Modified Peptides Mediate Effective siRNA Delivery.
3527,8579,40915339,10.1016/j.nano.2025.102856,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;conjugated,"delivery candidate; matched derived terms: delivery, nanoparticle, conjugated; source title: A novel treatment for diabetic nephropathy: Folate receptor-targeted delivery of TLR4 siRNA via functionalized PLGA nanoparticles in streptozotocin-induced diabetic murine models.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A novel treatment for diabetic nephropathy: Folate receptor-targeted delivery of TLR4 siRNA via functionalized PLGA nanoparticles in streptozotocin-induced diabetic murine models.
3535,8599,40898177,10.1186/s12896-025-01000-5,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Biomimetic nanoparticles coated with ScFv-modified macrophage membranes for siRNA delivery to relieve brain metastases of lung cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Biomimetic nanoparticles coated with ScFv-modified macrophage membranes for siRNA delivery to relieve brain metastases of lung cancer.
3536,8602,40897992,10.1007/s40263-025-01217-0,assay,ASO/siRNA,PubMed abstract sentence 11,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations.
3541,8613,40877518,10.1007/978-1-0716-4742-4_21,delivery,siRNA,PubMed abstract sentence 8,nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: nanoparticle, lnp, uptake; source title: Nanoparticle-Mediated siRNA Delivery in Human Epithelial Lung Cells Cultured at the Air-Liquid Interface.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticle-Mediated siRNA Delivery in Human Epithelial Lung Cells Cultured at the Air-Liquid Interface.
3543,8617,40877516,10.1007/978-1-0716-4742-4_19,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Bioinspired Extracellular Vesicles for Enhanced Delivery of siRNA to Tumors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Bioinspired Extracellular Vesicles for Enhanced Delivery of siRNA to Tumors.
3544,8618,40877516,10.1007/978-1-0716-4742-4_19,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bioinspired Extracellular Vesicles for Enhanced Delivery of siRNA to Tumors.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Bioinspired Extracellular Vesicles for Enhanced Delivery of siRNA to Tumors.
3545,8621,40877515,10.1007/978-1-0716-4742-4_18,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Formulation and Characterization of Cationic Bicelles for siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Formulation and Characterization of Cationic Bicelles for siRNA Delivery.
3547,8625,40877514,10.1007/978-1-0716-4742-4_17,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Optimization of DOTAP/Cholesterol Cationic Lipid Nanoparticles for Nucleic Acid Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimization of DOTAP/Cholesterol Cationic Lipid Nanoparticles for Nucleic Acid Delivery.
3548,8626,40877514,10.1007/978-1-0716-4742-4_17,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Optimization of DOTAP/Cholesterol Cationic Lipid Nanoparticles for Nucleic Acid Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Optimization of DOTAP/Cholesterol Cationic Lipid Nanoparticles for Nucleic Acid Delivery.
3550,8640,40870973,10.3390/pharmaceutics17080950,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Formulation-Driven Optimization of PEG-Lipid Content in Lipid Nanoparticles for Enhanced mRNA Delivery In Vitro and In Vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Formulation-Driven Optimization of PEG-Lipid Content in Lipid Nanoparticles for Enhanced mRNA Delivery In Vitro and In Vivo.
3552,8644,40869033,10.3390/ijms26167712,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Iron-Doped Hydroxyapatite Nanoparticles for Magnetic Guided siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Iron-Doped Hydroxyapatite Nanoparticles for Magnetic Guided siRNA Delivery.
3558,8654,40860190,10.7150/ijbs.109637,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: siRNA as a criterion in host immunity and cancer immunotherapy: modulating factors and nano-conjugate based approach for intervention.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA as a criterion in host immunity and cancer immunotherapy: modulating factors and nano-conjugate based approach for intervention.
3561,8663,40835583,10.1021/acsnano.5c05370,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Endogenous Targeting of Lipid Nanoparticles to Kidney Tumors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Endogenous Targeting of Lipid Nanoparticles to Kidney Tumors.
3568,8682,40818555,10.1016/j.ijpharm.2025.126073,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeting CCL2 silencing using polymer-lipid hybrid nanoparticles to reduce cytokine storm and inflammation in severe COVID-19.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting CCL2 silencing using polymer-lipid hybrid nanoparticles to reduce cytokine storm and inflammation in severe COVID-19.
3571,8687,40816350,10.1016/j.ejpb.2025.114838,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Novel electrosprayed core-shell polyethyleneimine and phospholipid coated MSNs for Co-delivery of KAZ3 and MDR-1 siRNA for efficient chemotherapy in multidrug-resistant colon cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel electrosprayed core-shell polyethyleneimine and phospholipid coated MSNs for Co-delivery of KAZ3 and MDR-1 siRNA for efficient chemotherapy in multidrug-resistant colon cancer.
3572,8688,40816350,10.1016/j.ejpb.2025.114838,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Novel electrosprayed core-shell polyethyleneimine and phospholipid coated MSNs for Co-delivery of KAZ3 and MDR-1 siRNA for efficient chemotherapy in multidrug-resistant colon cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Novel electrosprayed core-shell polyethyleneimine and phospholipid coated MSNs for Co-delivery of KAZ3 and MDR-1 siRNA for efficient chemotherapy in multidrug-resistant colon cancer.
3576,8696,40812552,10.1016/j.jconrel.2025.114122,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pre-silencing of TNF-α by targeted siRNA delivery mitigates glucocorticoid resistance of dexamethasone in rheumatoid arthritis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Pre-silencing of TNF-α by targeted siRNA delivery mitigates glucocorticoid resistance of dexamethasone in rheumatoid arthritis.
3583,8709,40787400,10.1021/acsomega.5c02145,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Gold Nanoparticle-mRNA Conjugates Encapsulated in Lipid Nanoparticles for Coordinated Codelivery of Multiple mRNAs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Gold Nanoparticle-mRNA Conjugates Encapsulated in Lipid Nanoparticles for Coordinated Codelivery of Multiple mRNAs.
3587,8719,40766677,10.1101/2025.07.31.667476,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Standardizing a Protocol for Streamlined Synthesis and Characterization of Lipid Nanoparticles to Enable Preclinical Research and Education.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Standardizing a Protocol for Streamlined Synthesis and Characterization of Lipid Nanoparticles to Enable Preclinical Research and Education.
3593,8733,40755461,10.2147/IJN.S527822,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivo.
3595,8737,40754985,10.1021/acsami.5c14143,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Positron Emission Tomography-Based Pharmacokinetics of mRNA-Lipid Nanoparticles: A Study Quantifying the ApoE and Macrophage Contribution.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Positron Emission Tomography-Based Pharmacokinetics of mRNA-Lipid Nanoparticles: A Study Quantifying the ApoE and Macrophage Contribution.
3600,8748,40747059,10.1021/jacsau.5c00474,delivery,siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Programmable Comodification of DNA Soccer Framework with Fluorocarbon and Aptamer for Efficient siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Programmable Comodification of DNA Soccer Framework with Fluorocarbon and Aptamer for Efficient siRNA Delivery.
3601,8749,40747059,10.1021/jacsau.5c00474,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Programmable Comodification of DNA Soccer Framework with Fluorocarbon and Aptamer for Efficient siRNA Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Programmable Comodification of DNA Soccer Framework with Fluorocarbon and Aptamer for Efficient siRNA Delivery.
3602,8752,40736337,10.1021/acsami.5c07808,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: TUBB3/DTX LNPs Dry Powder Inhaler and an Efficient Delivery Device for Targeted Therapy of Lung Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,TUBB3/DTX LNPs Dry Powder Inhaler and an Efficient Delivery Device for Targeted Therapy of Lung Cancer.
3603,8753,40736337,10.1021/acsami.5c07808,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: TUBB3/DTX LNPs Dry Powder Inhaler and an Efficient Delivery Device for Targeted Therapy of Lung Cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,TUBB3/DTX LNPs Dry Powder Inhaler and an Efficient Delivery Device for Targeted Therapy of Lung Cancer.
3607,8761,40735032,10.1016/j.jpha.2025.101203,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: pH-responsive biomimetic zeolitic imidazolate framework-based nanoparticles for co-delivery of cetuximab and siRNA in synergistic therapy of laryngeal squamous cell carcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,pH-responsive biomimetic zeolitic imidazolate framework-based nanoparticles for co-delivery of cetuximab and siRNA in synergistic therapy of laryngeal squamous cell carcinoma.
3609,8765,40720260,10.1021/acsami.5c07915,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: DNA Tetrahedron Nanodevice as a Co-delivery Vehicle of Shikonin and CpG Oligonucleotide for Enhanced Triple-Negative Breast Cancer Chemoimmunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,DNA Tetrahedron Nanodevice as a Co-delivery Vehicle of Shikonin and CpG Oligonucleotide for Enhanced Triple-Negative Breast Cancer Chemoimmunotherapy.
3614,8778,40716716,10.1016/j.biotechadv.2025.108643,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics.
3618,8784,40716251,10.1016/j.tranon.2025.102485,delivery,ASO,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Aptamer-mediated delivery of therapeutic oligonucleotides in glioblastoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-mediated delivery of therapeutic oligonucleotides in glioblastoma.
3620,8792,40708387,10.1002/smll.202502231,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Bypassing Endocytic Barriers: Visualizing Membrane Fusion and Endosomal Escape of Cubic Phase Lipid Nanoparticles (Cubosomes).",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Bypassing Endocytic Barriers: Visualizing Membrane Fusion and Endosomal Escape of Cubic Phase Lipid Nanoparticles (Cubosomes).
3622,8798,40706933,10.1016/j.ijbiomac.2025.146234,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Synergistic effect of Yes-associated protein siRNA and temozolomide against glioblastoma using a localized nano delivery system.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synergistic effect of Yes-associated protein siRNA and temozolomide against glioblastoma using a localized nano delivery system.
3624,8802,40705657,10.1080/17576180.2025.2535953,chemistry,siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Development of an LC-MS/MS assay to analyze a lipid-conjugated siRNA by solid phase extraction (SPE) in mouse plasma and tissue using a stable isotope labeled internal standard (SILIS).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of an LC-MS/MS assay to analyze a lipid-conjugated siRNA by solid phase extraction (SPE) in mouse plasma and tissue using a stable isotope labeled internal standard (SILIS).
3627,8807,40704506,10.1242/dmm.052370,chemistry,siRNA,PubMed abstract sentence 2,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs.
3628,8808,40704506,10.1242/dmm.052370,delivery,siRNA,PubMed abstract sentence 2,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs.
3630,8814,40694986,10.1016/j.prp.2025.156138,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Alendronate-functionalized ZIF-8 nanoplatform for targeted delivery of SHH siRNA and docetaxel to treat prostate cancer bone metastasis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Alendronate-functionalized ZIF-8 nanoplatform for targeted delivery of SHH siRNA and docetaxel to treat prostate cancer bone metastasis.
3633,8819,40688667,10.1016/j.mtbio.2025.102074,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Hyaluronic acid-anchored nanoparticles co-delivering emodin and siRNA confers protection against rheumatoid arthritis via macrophage polarization.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hyaluronic acid-anchored nanoparticles co-delivering emodin and siRNA confers protection against rheumatoid arthritis via macrophage polarization.
3636,8826,40687376,10.1016/j.omtm.2025.101518,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Rational design of lipid nanoparticles for enabling gene therapies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rational design of lipid nanoparticles for enabling gene therapies.
3640,8836,40681573,10.1038/s41598-025-10960-9,delivery,siRNA,PubMed abstract sentence 4,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Peptide dendrimer and hyaluronic acid modified nanovesicles for ocular delivery of timolol maleate and siRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Peptide dendrimer and hyaluronic acid modified nanovesicles for ocular delivery of timolol maleate and siRNA.
3643,8843,40675287,10.1016/j.ijbiomac.2025.145854,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Antibody targeted delivery of lipid nanoparticles for RNA therapeutics to immune cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antibody targeted delivery of lipid nanoparticles for RNA therapeutics to immune cells.
3647,8849,40673060,10.1016/j.omtm.2025.101513,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A systemically deliverable lipid-conjugated siRNA targeting DUX4 as an facioscapulohumeral muscular dystrophy therapeutic.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A systemically deliverable lipid-conjugated siRNA targeting DUX4 as an facioscapulohumeral muscular dystrophy therapeutic.
3648,8852,40671009,10.1186/s12951-025-03476-x,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: CXCL12-targeting siRNA nanoparticles alleviate immunosuppression and inhibit tumor progression in esophageal squamous cell carcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CXCL12-targeting siRNA nanoparticles alleviate immunosuppression and inhibit tumor progression in esophageal squamous cell carcinoma.
3652,8864,40661480,10.1101/2025.06.11.659145,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Controlling Payload Heterogeneity in Lipid Nanoparticles for RNA-Based Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Controlling Payload Heterogeneity in Lipid Nanoparticles for RNA-Based Therapeutics.
3655,8871,40654363,10.1016/j.apsb.2025.02.035,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged β-amyloid nanoscavenger for Alzheimer's disease therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged β-amyloid nanoscavenger for Alzheimer's disease therapy.
3658,8876,40646074,10.1038/s41598-025-10720-9,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanocarrier mediated DOX/siRNA targeted co-delivery for synergistic treatment of cutaneous melanoma in outdoor athletes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanocarrier mediated DOX/siRNA targeted co-delivery for synergistic treatment of cutaneous melanoma in outdoor athletes.
3664,8892,40633772,10.1016/j.jconrel.2025.114018,delivery,ASO,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Low-frequency ultrasound-mediated blood-brain barrier opening enables non-invasive lipid nanoparticle RNA delivery to glioblastoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Low-frequency ultrasound-mediated blood-brain barrier opening enables non-invasive lipid nanoparticle RNA delivery to glioblastoma.
3666,8896,40632915,10.1002/chem.202500303,delivery,siRNA,PubMed abstract sentence 1,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Spatially Coordinated Delivery of siRNA and Peptide Antagonist by Using Quantum Dots for Synergetic Cancer Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Spatially Coordinated Delivery of siRNA and Peptide Antagonist by Using Quantum Dots for Synergetic Cancer Therapy.
3668,8900,40618971,10.1016/j.actbio.2025.07.014,toxicity,siRNA,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A hydrated fibrous gene patch codelivers TGF-β1 siRNA/TAT and berberine for the treatment of peritendinous antiadhesion.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A hydrated fibrous gene patch codelivers TGF-β1 siRNA/TAT and berberine for the treatment of peritendinous antiadhesion.
3674,8912,40612625,10.1016/j.omtm.2025.101505,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Membrane-modified lipid nanoparticles for RNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Membrane-modified lipid nanoparticles for RNA delivery.
3676,8916,40606645,10.1016/j.omtn.2025.102579,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Albumin-binding dendritic siRNA improves delivery and efficacy to solid tumors in a melanoma model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Albumin-binding dendritic siRNA improves delivery and efficacy to solid tumors in a melanoma model.
3681,8925,40598893,10.1093/nar/gkaf600,delivery,siRNA,PubMed abstract sentence 6,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.
3683,8929,40598479,10.1186/s12951-025-03508-6,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy.
3685,8933,40598231,10.1186/s12951-025-03538-0,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeting YTHDF2 with pH-responsive siRNA nanoparticles suppresses MYC m6A modification and restores antitumor immunity in hepatocellular carcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting YTHDF2 with pH-responsive siRNA nanoparticles suppresses MYC m6A modification and restores antitumor immunity in hepatocellular carcinoma.
3686,8936,40595685,10.1038/s41467-025-60959-z,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cellular and biophysical barriers to lipid nanoparticle mediated delivery of RNA to the cytosol.
3688,8940,40589473,10.3389/fmedt.2025.1591119,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Enhancing nucleic acid delivery by the integration of artificial intelligence into lipid nanoparticle formulation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhancing nucleic acid delivery by the integration of artificial intelligence into lipid nanoparticle formulation.
3690,8946,40582845,10.1248/bpb.b25-00289,chemistry,siRNA,PubMed abstract sentence 8,chemical;modification;modified;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: chemical, modification, modified, phosphorothioate, 2'-o; source title: Development of a Gryllus bimaculatus-Based Assay System for Evaluating Chemically Modified siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of a Gryllus bimaculatus-Based Assay System for Evaluating Chemically Modified siRNAs.
3692,8950,40582054,10.1016/j.ultsonch.2025.107446,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A novel ultrasound-responsive cluster bomb system for efficient siRNA delivery in brain.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A novel ultrasound-responsive cluster bomb system for efficient siRNA delivery in brain.
3694,8954,40576767,10.1007/s00210-025-04381-8,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Multifunctional magnetic nanocapsules for dual delivery of siRNA and chemotherapy to MCF-7 cells (Breast cancer cells).",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multifunctional magnetic nanocapsules for dual delivery of siRNA and chemotherapy to MCF-7 cells (Breast cancer cells).
3695,8955,40576767,10.1007/s00210-025-04381-8,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Multifunctional magnetic nanocapsules for dual delivery of siRNA and chemotherapy to MCF-7 cells (Breast cancer cells).",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Multifunctional magnetic nanocapsules for dual delivery of siRNA and chemotherapy to MCF-7 cells (Breast cancer cells).
3696,8958,40576350,10.1097/CRD.0000000000000976,delivery,ASO/siRNA,PubMed abstract sentence 2,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: RNA Interference-Mediated ANGPTL3 Inhibition: The Emerging Therapeutic Potential of Zodasiran in Lipid Management.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA Interference-Mediated ANGPTL3 Inhibition: The Emerging Therapeutic Potential of Zodasiran in Lipid Management.
3697,8961,40573259,10.3390/ph18060864,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Engineering Lipid-Polymer Nanoparticles for siRNA Delivery to Cancer Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineering Lipid-Polymer Nanoparticles for siRNA Delivery to Cancer Cells.
3698,8962,40573259,10.3390/ph18060864,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineering Lipid-Polymer Nanoparticles for siRNA Delivery to Cancer Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Engineering Lipid-Polymer Nanoparticles for siRNA Delivery to Cancer Cells.
3701,8971,40555157,10.1016/j.bioadv.2025.214394,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Cationic lipopolymer based siRNA delivery for experimental lung cancer treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cationic lipopolymer based siRNA delivery for experimental lung cancer treatment.
3704,8976,40552643,10.1039/d5nr00788g,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Magnetic metal-organic frameworks as an antisense delivery platform and their performance in a cell-free protein expression system.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Magnetic metal-organic frameworks as an antisense delivery platform and their performance in a cell-free protein expression system.
3705,8979,40550952,10.1007/s11095-025-03884-6,delivery,siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Efficient Cytosolic Delivery of siRNA Using Lyophilized and Reconstituted Polymer-siRNA Polyplexes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient Cytosolic Delivery of siRNA Using Lyophilized and Reconstituted Polymer-siRNA Polyplexes.
3707,8987,40545892,10.1002/smll.202500114,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: On-Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,On-Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles.
3708,8992,40531611,10.1080/10717544.2025.2519470,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted treatment of hepatocellular carcinoma with aptamer-guided solid lipid nanoparticles loaded with norcantharidin.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted treatment of hepatocellular carcinoma with aptamer-guided solid lipid nanoparticles loaded with norcantharidin.
3710,8998,40522028,10.1002/adhm.202501031,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Therapeutic Lipid Nanoparticles Delivery of Small Interfering RNA for the Synergistic Treatment of Hepatic Inflammation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic Lipid Nanoparticles Delivery of Small Interfering RNA for the Synergistic Treatment of Hepatic Inflammation.
3712,9002,40521186,10.7150/thno.111200,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;conjugated;lnp,"delivery candidate; matched derived terms: nanoparticle, conjugated, lnp; source title: Precision treatment of ventilator-induced lung injury through alveolar epithelial cell targeted lipid nanoparticle delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Precision treatment of ventilator-induced lung injury through alveolar epithelial cell targeted lipid nanoparticle delivery.
3714,9006,40519236,10.1039/d4na01034e,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: RNA lipid nanoparticles stabilized during nebulization through excipient selection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA lipid nanoparticles stabilized during nebulization through excipient selection.
3718,9016,40495396,10.1021/acs.jpcb.5c01399,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Molecular Dynamics of Lipid Nanoparticles Explored through Solution and Solid-State NMR Spectroscopy and MD Simulations.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Molecular Dynamics of Lipid Nanoparticles Explored through Solution and Solid-State NMR Spectroscopy and MD Simulations.
3719,9019,40493869,10.1021/acsbiomaterials.5c00434,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Engineered Extracellular Vesicles for Tumor-Targeted Delivery of Therapeutic siRNA for Lung Cancer Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered Extracellular Vesicles for Tumor-Targeted Delivery of Therapeutic siRNA for Lung Cancer Therapy.
3721,9023,40493020,10.1021/acs.jctc.5c00498,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: In Silico Study of Ionizable Lipid Nanoparticles Using the SPICA Force Field.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Silico Study of Ionizable Lipid Nanoparticles Using the SPICA Force Field.
3722,9024,40493020,10.1021/acs.jctc.5c00498,assay,ASO/siRNA,PubMed abstract sentence 5,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: In Silico Study of Ionizable Lipid Nanoparticles Using the SPICA Force Field.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Silico Study of Ionizable Lipid Nanoparticles Using the SPICA Force Field.
3728,9038,40482891,10.1016/j.antiviral.2025.106210,assay,siRNA,PubMed abstract sentence 8,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Residual viral expression in siRNA-treated HBV-replicating cell and mouse models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Residual viral expression in siRNA-treated HBV-replicating cell and mouse models.
3730,9044,40480520,10.1016/j.jconrel.2025.113933,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: ATRA derived lipid nanoparticles for co-delivery of siCYP26A1 to overcome metabolic limitations of differentiation therapy in solid tumors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,ATRA derived lipid nanoparticles for co-delivery of siCYP26A1 to overcome metabolic limitations of differentiation therapy in solid tumors.
3732,9050,40471006,10.1002/cbic.202500169,chemistry,siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Synthesis of Chemically Diverse siRNA-Lipid Conjugates Enabled by Reversible Adsorption to Solid Support (RASS).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synthesis of Chemically Diverse siRNA-Lipid Conjugates Enabled by Reversible Adsorption to Solid Support (RASS).
3736,9056,40466858,10.1016/j.pupt.2025.102361,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of Dry Powder Inhaler formulation for site specific delivery of nanoconjugates loaded with Curcumin and BCL2 siRNA in Lung Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of Dry Powder Inhaler formulation for site specific delivery of nanoconjugates loaded with Curcumin and BCL2 siRNA in Lung Cancer.
3739,9063,40463820,10.3762/bjnano.16.57,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles.
3740,9068,40459028,10.1021/acsnano.4c18274,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Structure and Morphology of Lipid Nanoparticles for Nucleic Acid Drug Delivery: A Review.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structure and Morphology of Lipid Nanoparticles for Nucleic Acid Drug Delivery: A Review.
3742,9072,40457499,10.1186/s40035-025-00486-5,assay,ASO/siRNA,PubMed abstract sentence 5,screen;model,"assay candidate; matched derived terms: screen, model; source title: A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson's disease cell model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson's disease cell model.
3744,9076,40454419,10.1016/j.omtm.2025.101470,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Serum factors create species-specific barriers to hepatic gene transfer by lipid nanoparticles in liver-humanized mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Serum factors create species-specific barriers to hepatic gene transfer by lipid nanoparticles in liver-humanized mice.
3750,9088,40433119,10.2147/IJN.S510514,delivery,siRNA,PubMed abstract sentence 11,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipid-Coated Ag@MnO(2) Core-Shell Nanoparticles for Co-Delivery of Survivin siRNA in Breast Tumor Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid-Coated Ag@MnO(2) Core-Shell Nanoparticles for Co-Delivery of Survivin siRNA in Breast Tumor Therapy.
3751,9089,40433119,10.2147/IJN.S510514,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid-Coated Ag@MnO(2) Core-Shell Nanoparticles for Co-Delivery of Survivin siRNA in Breast Tumor Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Lipid-Coated Ag@MnO(2) Core-Shell Nanoparticles for Co-Delivery of Survivin siRNA in Breast Tumor Therapy.
3752,9092,40425752,10.1038/s41598-025-03309-9,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Laminar fluid ejection device enables high yield and preservation of mRNA and SaRNA LNP formulations.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Laminar fluid ejection device enables high yield and preservation of mRNA and SaRNA LNP formulations.
3754,9096,40425136,10.1016/j.cca.2025.120387,assay,siRNA,PubMed abstract sentence 1,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: MUC1 as a diagnostic biomarker and siRNA-based therapeutic target in breast cancer: A clinical chemistry perspective.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MUC1 as a diagnostic biomarker and siRNA-based therapeutic target in breast cancer: A clinical chemistry perspective.
3755,9099,40422763,10.3390/membranes15050153,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Mesoscopic Structure of Lipid Nanoparticles Studied by Small-Angle X-Ray Scattering: A Spherical Core-Triple Shell Model Analysis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mesoscopic Structure of Lipid Nanoparticles Studied by Small-Angle X-Ray Scattering: A Spherical Core-Triple Shell Model Analysis.
3757,9101,40422763,10.3390/membranes15050153,benchmark,ASO/siRNA,PubMed abstract sentence 7,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Mesoscopic Structure of Lipid Nanoparticles Studied by Small-Angle X-Ray Scattering: A Spherical Core-Triple Shell Model Analysis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mesoscopic Structure of Lipid Nanoparticles Studied by Small-Angle X-Ray Scattering: A Spherical Core-Triple Shell Model Analysis.
3761,9115,40409482,10.1016/j.ymeth.2025.05.007,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Enhancing RNA Delivery: Practical insights into NeoLNP(TM) transfection reagent.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhancing RNA Delivery: Practical insights into NeoLNP(TM) transfection reagent.
3763,9119,40407475,10.3390/mps8030048,assay,ASO/siRNA,PubMed abstract sentence 10,assay;screen;preclinical;phase,"assay candidate; matched derived terms: assay, screen, preclinical, phase; source title: Empagliflozin Repurposing for Lafora Disease: A Pilot Clinical Trial and Preclinical Investigation of Novel Therapeutic Targets.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Empagliflozin Repurposing for Lafora Disease: A Pilot Clinical Trial and Preclinical Investigation of Novel Therapeutic Targets.
3767,9127,40402247,10.1073/pnas.2426601122,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: nanoparticle, lnp, uptake; source title: Multiparametric functional characterization of individual lipid nanoparticles using surface-sensitive light-scattering microscopy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multiparametric functional characterization of individual lipid nanoparticles using surface-sensitive light-scattering microscopy.
3770,9134,40399008,10.1016/j.carbpol.2025.123581,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Chitosan nanovectors for siRNA delivery: New horizons for nonviral gene therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chitosan nanovectors for siRNA delivery: New horizons for nonviral gene therapy.
3772,9138,40396945,10.1021/acsbiomaterials.4c02373,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Optimizing Microfluidic Channel Design with Tilted Rectangular Baffles for Enhanced mRNA-Lipid Nanoparticle Preparation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimizing Microfluidic Channel Design with Tilted Rectangular Baffles for Enhanced mRNA-Lipid Nanoparticle Preparation.
3773,9143,40393530,10.1016/j.jconrel.2025.113856,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Single particle charge detection mass spectrometry enables molecular characterization of lipid nanoparticles and mRNA packaging.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Single particle charge detection mass spectrometry enables molecular characterization of lipid nanoparticles and mRNA packaging.
3775,9149,40381523,10.1016/j.biomaterials.2025.123411,delivery,siRNA,PubMed abstract sentence 2,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Local delivery of siRNA using lipid-based nanocarriers with ROS-scavenging ability for accelerated chronic wound healing in diabetes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Local delivery of siRNA using lipid-based nanocarriers with ROS-scavenging ability for accelerated chronic wound healing in diabetes.
3779,9157,40379798,10.1038/s41551-025-01376-x,chemistry,siRNA,PubMed abstract sentence 4,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs.
3782,9162,40375057,10.1002/cpt.3690,assay,siRNA,PubMed abstract sentence 3,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Population Pharmacokinetics of siRNA JNJ-73763989 in Healthy Participants and Patients With Chronic Hepatitis B.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Population Pharmacokinetics of siRNA JNJ-73763989 in Healthy Participants and Patients With Chronic Hepatitis B.
3783,9167,40366254,10.1002/mabi.202500165,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Histidine Decapeptide-Incorporating Lipid Nanoparticles with Low Ionizable Lipids Proportion for Efficient Small Interfering RNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Histidine Decapeptide-Incorporating Lipid Nanoparticles with Low Ionizable Lipids Proportion for Efficient Small Interfering RNA Delivery.
3785,9171,40364633,10.1002/adhm.202500107,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Engineered Chitosan-Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered Chitosan-Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons.
3787,9175,40363763,10.3390/molecules30091956,chemistry,ASO,PubMed abstract sentence 3,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Conditional Control of CRISPR/Cas9 Function by Chemically Modified Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Conditional Control of CRISPR/Cas9 Function by Chemically Modified Oligonucleotides.
3788,9178,40359485,10.1021/acsbiomaterials.4c01925,delivery,siRNA,PubMed abstract sentence 9,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: SiRNA-Targeting TGF-β1 Based on Nanoparticle-Coated Ureteral Stents to Inhibit Ureteral Stricture.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,SiRNA-Targeting TGF-β1 Based on Nanoparticle-Coated Ureteral Stents to Inhibit Ureteral Stricture.
3797,9197,40338223,10.1021/acsnano.5c01641,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeting Ischemic Myocardium: Nanoparticles Loaded with Long Noncoding RNA AK156373 siRNA Alleviate Myocardial Infarction.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting Ischemic Myocardium: Nanoparticles Loaded with Long Noncoding RNA AK156373 siRNA Alleviate Myocardial Infarction.
3798,9200,40328700,10.13345/j.cjb.240600,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: [Fabrication of chitosan/hyaluronic acid complex nanoparticles for effective siRNA delivery].",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,[Fabrication of chitosan/hyaluronic acid complex nanoparticles for effective siRNA delivery].
3799,9201,40328700,10.13345/j.cjb.240600,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: [Fabrication of chitosan/hyaluronic acid complex nanoparticles for effective siRNA delivery].",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,[Fabrication of chitosan/hyaluronic acid complex nanoparticles for effective siRNA delivery].
3800,9204,40325908,10.1021/acsami.5c06464,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Transition Temperature-Guided Design of Lipid Nanoparticles for Effective mRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transition Temperature-Guided Design of Lipid Nanoparticles for Effective mRNA Delivery.
3802,9208,40314193,10.1080/13880209.2025.2498169,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection.
3803,9209,40314193,10.1080/13880209.2025.2498169,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection.
3806,9220,40306576,10.1016/j.jconrel.2025.113790,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Formulation of siRNA nanoparticles, transfection and enhanced adhesion -penetration in nasal mucosal tissue.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Formulation of siRNA nanoparticles, transfection and enhanced adhesion -penetration in nasal mucosal tissue."
3809,9227,40293309,10.1021/jacs.5c03033,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Topologically Engineered Supramolecular Cyclolipid Nanoparticles: A Custom-Tailored Delivery System for Inhaled Combination Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Topologically Engineered Supramolecular Cyclolipid Nanoparticles: A Custom-Tailored Delivery System for Inhaled Combination Therapy.
3811,9233,40267508,10.1021/acsabm.4c01716,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Machine-Learning Framework to Predict the Performance of Lipid Nanoparticles for Nucleic Acid Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Machine-Learning Framework to Predict the Performance of Lipid Nanoparticles for Nucleic Acid Delivery.
3812,9234,40267508,10.1021/acsabm.4c01716,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Machine-Learning Framework to Predict the Performance of Lipid Nanoparticles for Nucleic Acid Delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Machine-Learning Framework to Predict the Performance of Lipid Nanoparticles for Nucleic Acid Delivery.
3813,9243,40253509,10.1038/s43856-025-00847-1,assay,siRNA,PubMed abstract sentence 10,screen;model,"assay candidate; matched derived terms: screen, model; source title: Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies.
3816,9250,40237047,10.2174/0113892010363276250405191808,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: siRNA Therapeutics in Lymphoma: Gene Targets, Delivery Strategies, and Synergy with Chemotherapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"siRNA Therapeutics in Lymphoma: Gene Targets, Delivery Strategies, and Synergy with Chemotherapy."
3817,9253,40235852,10.1016/j.omtn.2025.102522,delivery,ASO,PubMed abstract sentence 9,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro.
3820,9258,40215342,10.1158/2326-6066.CIR-24-0333,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: First-in-Human Clinical Trial of Vaccination with WDVAX, a Dendritic Cell-Activating Scaffold Incorporating Autologous Tumor Cell Lysate, in Patients with Metastatic Melanoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"First-in-Human Clinical Trial of Vaccination with WDVAX, a Dendritic Cell-Activating Scaffold Incorporating Autologous Tumor Cell Lysate, in Patients with Metastatic Melanoma."
3823,9265,40185334,10.1016/j.jconrel.2025.113681,delivery,siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery.
3827,9271,40176316,10.1021/acsnano.4c14625,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;conjugated;lnp,"delivery candidate; matched derived terms: delivery, conjugated, lnp; source title: Peptide-Modified Lipid Nanoparticles Boost the Antitumor Efficacy of RNA Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Peptide-Modified Lipid Nanoparticles Boost the Antitumor Efficacy of RNA Therapeutics.
3828,9274,40175880,10.1007/978-1-0716-4394-5_18,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A Robust Post-Insertion Method for the Preparation of Targeted Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Robust Post-Insertion Method for the Preparation of Targeted Lipid Nanoparticles.
3830,9280,40162630,10.1002/advs.202416747,delivery,ASO,PubMed abstract sentence 11,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticle Delivery of Antisense miR162 Inhibits Invasive Habitat Adaption of Alternanthera Philoxeroides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticle Delivery of Antisense miR162 Inhibits Invasive Habitat Adaption of Alternanthera Philoxeroides.
3834,9290,40143003,10.3390/pharmaceutics17030339,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Analysis of Polymer/siRNA Nanoparticle Efficacy and Biocompatibility in 3D Air-Liquid Interface Culture Compared to 2D Cell Culture.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Analysis of Polymer/siRNA Nanoparticle Efficacy and Biocompatibility in 3D Air-Liquid Interface Culture Compared to 2D Cell Culture.
3835,9293,40135901,10.1021/acs.molpharmaceut.4c01437,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Molecular Insight into Lipid Nanoparticle Assembly from NMR Spectroscopy and Molecular Dynamics Simulation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Molecular Insight into Lipid Nanoparticle Assembly from NMR Spectroscopy and Molecular Dynamics Simulation.
3836,9296,40134240,10.1021/acs.bioconjchem.5c00096,delivery,siRNA,PubMed abstract sentence 1,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Evolution of Lipo-Xenopeptide Carriers for siRNA Delivery: Interplay of Stabilizing Subunits.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evolution of Lipo-Xenopeptide Carriers for siRNA Delivery: Interplay of Stabilizing Subunits.
3838,9300,40131145,10.1021/acs.molpharmaceut.4c00871,assay,ASO/siRNA,PubMed abstract sentence 6,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Non-Viral RNA Therapies for Non-Small Cell Lung Cancer and Their Corresponding Clinical Trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Non-Viral RNA Therapies for Non-Small Cell Lung Cancer and Their Corresponding Clinical Trials.
3839,9303,40126051,10.1080/17425247.2025.2484287,delivery,siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells.
3846,9330,40056044,10.1002/advs.202500844,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy.
3847,9331,40056044,10.1002/advs.202500844,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy.
3849,9335,40046817,10.2147/IJN.S497428,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Injured Cardiac Tissue-Targeted Delivery of TGFβ1 siRNA by FAP Aptamer-Functionalized Extracellular Vesicles Promotes Cardiac Repair.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Injured Cardiac Tissue-Targeted Delivery of TGFβ1 siRNA by FAP Aptamer-Functionalized Extracellular Vesicles Promotes Cardiac Repair.
3850,9338,40035593,10.1128/mbio.03983-24,delivery,ASO,PubMed abstract sentence 8,uptake;route,"delivery candidate; matched derived terms: uptake, route; source title: RNA toehold switch-based reporter assay to assess bacterial uptake of antisense oligomers.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA toehold switch-based reporter assay to assess bacterial uptake of antisense oligomers.
3851,9339,40035593,10.1128/mbio.03983-24,assay,ASO,PubMed abstract sentence 6,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: RNA toehold switch-based reporter assay to assess bacterial uptake of antisense oligomers.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA toehold switch-based reporter assay to assess bacterial uptake of antisense oligomers.
3853,9343,40035513,10.1002/adma.202418053,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Engineered Bacterial Outer Membrane Vesicles-Based Doxorubicin and CD47-siRNA Co-Delivery Nanoplatform Overcomes Immune Resistance to Potentiate the Immunotherapy of Glioblastoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineered Bacterial Outer Membrane Vesicles-Based Doxorubicin and CD47-siRNA Co-Delivery Nanoplatform Overcomes Immune Resistance to Potentiate the Immunotherapy of Glioblastoma.
3854,9346,40028836,10.1111/all.16515,assay,siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Phase 2-3 Trial: Prevention of the Progression to Moderate and Severe COVID-19 in SARS-CoV-2-Infected Non-Hospitalized Adults With Inhaled siRNA-Based MIR 19.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phase 2-3 Trial: Prevention of the Progression to Moderate and Severe COVID-19 in SARS-CoV-2-Infected Non-Hospitalized Adults With Inhaled siRNA-Based MIR 19.
3860,9360,40010411,10.1016/j.jconrel.2025.02.067,delivery,siRNA,PubMed abstract sentence 7,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Surfactant protein B-derived peptides as endosomal escape enhancers for pulmonary delivery of siRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Surfactant protein B-derived peptides as endosomal escape enhancers for pulmonary delivery of siRNA.
3862,9366,39990947,10.1021/acsbiomedchemau.4c00061,delivery,ASO/siRNA,PubMed abstract sentence 6,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Development of Small Interfering RNA Loaded Cationic Lipid Nanoparticles for the Treatment of Liver Cancer with Elevated α-Fetoprotein Expression.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of Small Interfering RNA Loaded Cationic Lipid Nanoparticles for the Treatment of Liver Cancer with Elevated α-Fetoprotein Expression.
3863,9367,39990947,10.1021/acsbiomedchemau.4c00061,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of Small Interfering RNA Loaded Cationic Lipid Nanoparticles for the Treatment of Liver Cancer with Elevated α-Fetoprotein Expression.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of Small Interfering RNA Loaded Cationic Lipid Nanoparticles for the Treatment of Liver Cancer with Elevated α-Fetoprotein Expression.
3864,9370,39987112,10.1186/s12951-025-03172-w,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Engineered neutrophil membrane-camouflaged nanocomplexes for targeted siRNA delivery against myocardial ischemia reperfusion injury.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered neutrophil membrane-camouflaged nanocomplexes for targeted siRNA delivery against myocardial ischemia reperfusion injury.
3866,9374,39980062,10.1111/cts.70169,toxicity,ASO,PubMed abstract sentence 10,risk;proarrhythmic,"toxicity candidate; matched derived terms: risk, proarrhythmic; source title: Low Proarrhythmic Risk of Imetelstat, a Novel Oligonucleotide Telomerase Inhibitor: A Translational Analysis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Low Proarrhythmic Risk of Imetelstat, a Novel Oligonucleotide Telomerase Inhibitor: A Translational Analysis."
3870,9388,39967318,10.1002/psc.70007,delivery,siRNA,PubMed abstract sentence 7,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Cancer-Targeting Peptides Functionalized With Polyarginine Enables GRP78-Dependent Cell Uptake and siRNA Delivery Within the DU145 Prostate Cancer Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cancer-Targeting Peptides Functionalized With Polyarginine Enables GRP78-Dependent Cell Uptake and siRNA Delivery Within the DU145 Prostate Cancer Cells.
3874,9396,39946970,10.1016/j.jcis.2025.02.034,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Scalable production of uniform gene-loaded lipid nanoparticles via a fluidity-controlled membrane extrusion.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Scalable production of uniform gene-loaded lipid nanoparticles via a fluidity-controlled membrane extrusion.
3875,9399,39934917,10.1186/s13287-025-04151-6,delivery,siRNA,PubMed abstract sentence 11,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Development and evaluation of siRNA-mediated gene silencing strategies for ADO2 therapy utilizing iPSCs model and DMPC-SPIONs delivery system.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development and evaluation of siRNA-mediated gene silencing strategies for ADO2 therapy utilizing iPSCs model and DMPC-SPIONs delivery system.
3877,9401,39934917,10.1186/s13287-025-04151-6,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development and evaluation of siRNA-mediated gene silencing strategies for ADO2 therapy utilizing iPSCs model and DMPC-SPIONs delivery system.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development and evaluation of siRNA-mediated gene silencing strategies for ADO2 therapy utilizing iPSCs model and DMPC-SPIONs delivery system.
3880,9406,39924757,10.1002/adma.202415643,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Modular Design of Lipopeptide-Based Organ-Specific Targeting (POST) Lipid Nanoparticles for Highly Efficient RNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modular Design of Lipopeptide-Based Organ-Specific Targeting (POST) Lipid Nanoparticles for Highly Efficient RNA Delivery.
3882,9410,39923604,10.1016/j.bioadv.2025.214202,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: High-density lipoprotein-like nanoparticles with cationic cholesterol derivatives for siRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-density lipoprotein-like nanoparticles with cationic cholesterol derivatives for siRNA delivery.
3883,9411,39923604,10.1016/j.bioadv.2025.214202,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: High-density lipoprotein-like nanoparticles with cationic cholesterol derivatives for siRNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,High-density lipoprotein-like nanoparticles with cationic cholesterol derivatives for siRNA delivery.
3890,9424,39907973,10.1007/s13346-025-01800-4,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Topical delivery of siRNA to psoriatic skin model using high molecular weight chitosan derivatives: In vitro and in vivo studies.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Topical delivery of siRNA to psoriatic skin model using high molecular weight chitosan derivatives: In vitro and in vivo studies.
3893,9431,39904731,10.1002/anie.202425654,chemistry,ASO,PubMed abstract sentence 1,modification;conjugate,"chemistry candidate; matched derived terms: modification, conjugate; source title: NIR-II Emissive Oligonucleotides Grafted π-Conjugated Polymers for Low-Temperature Photothermal and Gene Combined Therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,NIR-II Emissive Oligonucleotides Grafted π-Conjugated Polymers for Low-Temperature Photothermal and Gene Combined Therapy.
3894,9432,39904731,10.1002/anie.202425654,delivery,ASO,PubMed abstract sentence 2,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: NIR-II Emissive Oligonucleotides Grafted π-Conjugated Polymers for Low-Temperature Photothermal and Gene Combined Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,NIR-II Emissive Oligonucleotides Grafted π-Conjugated Polymers for Low-Temperature Photothermal and Gene Combined Therapy.
3900,9446,39864683,10.1016/j.ijbiomac.2025.140318,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Urchin-like magnetic nanoparticles loaded with type X collagen siRNA and Stattic to treat triple negative breast cancer under rotating magnetic field like an ""enchanted micro-scalpel"".",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Urchin-like magnetic nanoparticles loaded with type X collagen siRNA and Stattic to treat triple negative breast cancer under rotating magnetic field like an ""enchanted micro-scalpel""."
3911,9469,39824529,10.1136/jitc-2024-010579,toxicity,ASO/siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines.
3913,9473,39824265,10.1016/j.ijpharm.2025.125192,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Ether bond-modified lipid nanoparticles for enhancing the treatment effect of hepatic fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ether bond-modified lipid nanoparticles for enhancing the treatment effect of hepatic fibrosis.
3916,9480,39811495,10.1016/j.omtn.2024.102423,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Restoring hematopoietic stem and progenitor cell function in Fancc (-/-) mice by in situ delivery of RNA lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Restoring hematopoietic stem and progenitor cell function in Fancc (-/-) mice by in situ delivery of RNA lipid nanoparticles.
3920,9488,39804640,10.1001/jamaneurol.2024.4631,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Five-Year Results With Patisiran for Hereditary Transthyretin Amyloidosis With Polyneuropathy: A Randomized Clinical Trial With Open-Label Extension.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Five-Year Results With Patisiran for Hereditary Transthyretin Amyloidosis With Polyneuropathy: A Randomized Clinical Trial With Open-Label Extension.
3926,9506,39772535,10.1021/acs.jmedchem.4c02528,delivery,ASO,PubMed abstract sentence 7,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Metabolic Stability and Targeted Delivery of Oligonucleotides: Advancing RNA Therapeutics Beyond The Liver.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Metabolic Stability and Targeted Delivery of Oligonucleotides: Advancing RNA Therapeutics Beyond The Liver.
3936,9530,39705128,10.1021/acsami.4c12805,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Syringable Microcapsules for Sustained, Localized, and Controllable siRNA Delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Syringable Microcapsules for Sustained, Localized, and Controllable siRNA Delivery."
3940,9542,39648859,10.1080/22221751.2024.2438658,delivery,siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance."
3950,9566,39320435,10.1007/s13346-024-01709-4,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Oral delivery of stabilized lipid nanoparticles for nucleic acid therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oral delivery of stabilized lipid nanoparticles for nucleic acid therapeutics.
3952,9570,39314170,10.4103/NRR.NRR-D-24-00303,delivery,siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanocarrier-mediated siRNA delivery: a new approach for the treatment of traumatic brain injury-related Alzheimer's disease.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanocarrier-mediated siRNA delivery: a new approach for the treatment of traumatic brain injury-related Alzheimer's disease.
3954,9574,39092676,10.1002/smtd.202400902,delivery,ASO,PubMed abstract sentence 4,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona-Assisted DNA Cubes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona-Assisted DNA Cubes.
3956,9580,38918987,10.2174/0115672018306882240618093152,delivery,ASO,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanocarriers: Exploring the Potential of Oligonucleotide Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanocarriers: Exploring the Potential of Oligonucleotide Delivery.
3958,9584,38918983,10.2174/0115665240307413240531111140,delivery,siRNA,PubMed abstract sentence 12,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: siRNA Treatments for Diabetic Neuropathy: Obstacles and Delivery Techniques.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA Treatments for Diabetic Neuropathy: Obstacles and Delivery Techniques.
3960,9588,40836980,10.3389/fddev.2024.1416737,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Dual conjugation of magnetic nanoparticles with antibodies and siRNA for cell-specific gene silencing in vascular cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dual conjugation of magnetic nanoparticles with antibodies and siRNA for cell-specific gene silencing in vascular cells.
3965,9599,40074308,10.11817/j.issn.1672-7347.2024.230247,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In vitro study of a siRNA delivery liposome constructed with an ionizable cationic lipid.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In vitro study of a siRNA delivery liposome constructed with an ionizable cationic lipid.
3968,9610,39697635,10.20517/evcna.2024.19,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design.
3972,9620,39651078,10.1021/acsomega.4c05808,delivery,siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Comparison of Cell-Penetrating and Fusogenic TAT-HA2 Peptide Performance in Peptideplex, Multicomponent, and Conjugate siRNA Delivery Systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Comparison of Cell-Penetrating and Fusogenic TAT-HA2 Peptide Performance in Peptideplex, Multicomponent, and Conjugate siRNA Delivery Systems."
3973,9621,39651078,10.1021/acsomega.4c05808,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Comparison of Cell-Penetrating and Fusogenic TAT-HA2 Peptide Performance in Peptideplex, Multicomponent, and Conjugate siRNA Delivery Systems.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Comparison of Cell-Penetrating and Fusogenic TAT-HA2 Peptide Performance in Peptideplex, Multicomponent, and Conjugate siRNA Delivery Systems."
3974,9624,39598489,10.3390/pharmaceutics16111366,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: The Impact of COVID-19 on RNA Therapeutics: A Surge in Lipid Nanoparticles and Alternative Delivery Systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Impact of COVID-19 on RNA Therapeutics: A Surge in Lipid Nanoparticles and Alternative Delivery Systems.
3976,9628,39593088,10.1186/s12951-024-03003-4,delivery,siRNA,PubMed abstract sentence 9,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Sele-targeted siRNA liposome nanoparticles inhibit pathological scars formation via blocking the cross-talk between monocyte and endothelial cells: a preclinical study based on a novel mice scar model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Sele-targeted siRNA liposome nanoparticles inhibit pathological scars formation via blocking the cross-talk between monocyte and endothelial cells: a preclinical study based on a novel mice scar model.
3986,9654,39490384,10.1016/j.addr.2024.115461,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids.
3990,9660,39464033,10.1101/2024.10.14.618042,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synthesis and characterization of chloroquine-modified albumin-binding siRNA-lipid conjugates for improved intracellular delivery and gene silencing in cancer cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synthesis and characterization of chloroquine-modified albumin-binding siRNA-lipid conjugates for improved intracellular delivery and gene silencing in cancer cells.
3995,9673,39419450,10.1016/j.jconrel.2024.10.027,delivery,siRNA,PubMed abstract sentence 6,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Inulin-based nanoparticles for targeted siRNA delivery in acute kidney injury.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inulin-based nanoparticles for targeted siRNA delivery in acute kidney injury.
3998,9678,39406303,10.1016/j.ijpharm.2024.124835,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Fabrication and evaluation of chitosan-coated nanostructured lipid carriers for co-delivery of paclitaxel and PD-L1 siRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Fabrication and evaluation of chitosan-coated nanostructured lipid carriers for co-delivery of paclitaxel and PD-L1 siRNA.
3999,9681,39401676,10.1016/j.jconrel.2024.10.014,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: The future of genetic medicines delivered via targeted lipid nanoparticles to leukocytes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The future of genetic medicines delivered via targeted lipid nanoparticles to leukocytes.
4006,9692,39388218,10.1021/acs.molpharmaceut.4c00743,toxicity,siRNA,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted Delivery of AR-V7 siRNA with Bivalent PSMA Aptamers Effectively Suppresses the Growth of Enzalutamide-Resistant Prostate Cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeted Delivery of AR-V7 siRNA with Bivalent PSMA Aptamers Effectively Suppresses the Growth of Enzalutamide-Resistant Prostate Cancer.
4011,9709,39320858,10.1080/20415990.2024.2400044,delivery,siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Therapeutic delivery of siRNA for the management of breast cancer and triple-negative breast cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic delivery of siRNA for the management of breast cancer and triple-negative breast cancer.
4012,9710,39320858,10.1080/20415990.2024.2400044,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Therapeutic delivery of siRNA for the management of breast cancer and triple-negative breast cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Therapeutic delivery of siRNA for the management of breast cancer and triple-negative breast cancer.
4013,9713,39297413,10.1002/advs.202403442,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: siRNA/CS-PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA/CS-PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity.
4014,9716,39296267,10.1021/acsptsci.4c00336,delivery,siRNA,PubMed abstract sentence 4,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Lipopolymer/siRNA Nanoparticles Targeting the Signal Transducer and Activator of Transcription 5A Disrupts Proliferation of Acute Lymphoblastic Leukemia.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipopolymer/siRNA Nanoparticles Targeting the Signal Transducer and Activator of Transcription 5A Disrupts Proliferation of Acute Lymphoblastic Leukemia.
4015,9719,39279550,10.1002/eji.202451008,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticle-mediated RNA delivery for immune cell modulation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle-mediated RNA delivery for immune cell modulation.
4017,9723,39276676,10.1016/j.neurot.2024.e00443,assay,ASO/siRNA,PubMed abstract sentence 3,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Gene therapy for the leukodystrophies: From preclinical animal studies to clinical trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Gene therapy for the leukodystrophies: From preclinical animal studies to clinical trials.
4018,9726,39263399,10.1039/d4na00363b,delivery,siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Efficient siRNA delivery to murine melanoma cells via a novel genipin-based nano-polymer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient siRNA delivery to murine melanoma cells via a novel genipin-based nano-polymer.
4019,9727,39263399,10.1039/d4na00363b,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Efficient siRNA delivery to murine melanoma cells via a novel genipin-based nano-polymer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficient siRNA delivery to murine melanoma cells via a novel genipin-based nano-polymer.
4023,9739,39225471,10.1002/cpz1.1121,assay,siRNA,PubMed abstract sentence 1,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: A Facile, Transfection-Free Approach to siRNA Delivery in In Vitro 3D Spheroid Models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A Facile, Transfection-Free Approach to siRNA Delivery in In Vitro 3D Spheroid Models."
4025,9741,39225471,10.1002/cpz1.1121,benchmark,siRNA,PubMed abstract sentence 6,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: A Facile, Transfection-Free Approach to siRNA Delivery in In Vitro 3D Spheroid Models.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A Facile, Transfection-Free Approach to siRNA Delivery in In Vitro 3D Spheroid Models."
4029,9753,39204368,10.3390/pharmaceutics16081023,chemistry,ASO,PubMed abstract sentence 2,phosphorothioate;conjugate,"chemistry candidate; matched derived terms: phosphorothioate, conjugate; source title: In Vitro Studies to Evaluate the Intestinal Permeation of an Ursodeoxycholic Acid-Conjugated Oligonucleotide for Duchenne Muscular Dystrophy Treatment.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vitro Studies to Evaluate the Intestinal Permeation of an Ursodeoxycholic Acid-Conjugated Oligonucleotide for Duchenne Muscular Dystrophy Treatment.
4033,9761,39201751,10.3390/ijms25169065,assay,ASO,PubMed abstract sentence 7,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Oligonucleotide Therapies for Facioscapulohumeral Muscular Dystrophy: Current Preclinical Landscape.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oligonucleotide Therapies for Facioscapulohumeral Muscular Dystrophy: Current Preclinical Landscape.
4037,9773,39166716,10.1111/jocd.16535,assay,siRNA,PubMed abstract sentence 4,experiment;trial,"assay candidate; matched derived terms: experiment, trial; source title: Novel injectable polypeptide nanoparticle encapsulated siRNA targeting TGF-β1 and COX-2 for localized fat reduction I: Preclinical in vitro and animal models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel injectable polypeptide nanoparticle encapsulated siRNA targeting TGF-β1 and COX-2 for localized fat reduction I: Preclinical in vitro and animal models.
4043,9783,39139067,10.1089/hum.2024.106,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid Nanoparticles for Nucleic Acid Delivery Beyond the Liver.",C,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid Nanoparticles for Nucleic Acid Delivery Beyond the Liver.
4045,9787,39134513,10.1093/bbb/zbae112,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Soymilk yogurt fermented using Pediococcus pentosaceus TOKAI 759 m improves mice gut microbiota and reduces pro-inflammatory cytokine production.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Soymilk yogurt fermented using Pediococcus pentosaceus TOKAI 759 m improves mice gut microbiota and reduces pro-inflammatory cytokine production.
4049,9797,39098747,10.1016/j.ijpharm.2024.124545,delivery,siRNA,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Enhancing siRNA cancer therapy: Multifaceted strategies with lipid and polymer-based carrier systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhancing siRNA cancer therapy: Multifaceted strategies with lipid and polymer-based carrier systems.
4054,9812,39053429,10.1016/j.biopha.2024.117185,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Carboxylated mesoporous silica nanoparticle-nucleic acid chimera conjugate-assisted delivery of siRNA and doxorubicin effectively treat drug-resistant bladder cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Carboxylated mesoporous silica nanoparticle-nucleic acid chimera conjugate-assisted delivery of siRNA and doxorubicin effectively treat drug-resistant bladder cancer.
4057,9823,39005878,10.1016/j.omtn.2024.102236,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid nanoparticle technology-mediated therapeutic gene manipulation in the eyes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle technology-mediated therapeutic gene manipulation in the eyes.
4061,9837,38938759,10.1016/j.omtn.2024.102230,chemistry,siRNA,PubMed abstract sentence 9,chemical;conjugate,"chemistry candidate; matched derived terms: chemical, conjugate; source title: Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA.
4069,9863,38839059,10.1021/acsnano.4c02341,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Single-Particle Spectroscopic Chromatography Reveals Heterogeneous RNA Loading and Size Correlations in Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Single-Particle Spectroscopic Chromatography Reveals Heterogeneous RNA Loading and Size Correlations in Lipid Nanoparticles.
4070,9866,38832305,10.1016/j.bioactmat.2024.05.020,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model.
4074,9874,38779139,10.34133/bmr.0017,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Development of Lipid Nanoparticle Formulation for the Repeated Administration of mRNA Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of Lipid Nanoparticle Formulation for the Repeated Administration of mRNA Therapeutics.
4075,9877,38771665,10.1021/acs.biomac.4c00025,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Tumor-Targeted Codelivery of CpG and siRNA by a Dual-Ligand-Functionalized Curdlan Nanoparticle.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tumor-Targeted Codelivery of CpG and siRNA by a Dual-Ligand-Functionalized Curdlan Nanoparticle.
4079,9885,38733412,10.1007/s00223-024-01222-3,delivery,siRNA,PubMed abstract sentence 6,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Effect of Allele-Specific Clcn7(G213R) siRNA Delivered Via a Novel Nanocarrier on Bone Phenotypes in ADO2 Mice on 129S Background.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of Allele-Specific Clcn7(G213R) siRNA Delivered Via a Novel Nanocarrier on Bone Phenotypes in ADO2 Mice on 129S Background.
4081,9889,38692174,10.1016/j.colsurfb.2024.113930,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: MCT4 knockdown by tumor microenvironment-responsive nanoparticles remodels the cytokine profile and eradicates aggressive breast cancer cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MCT4 knockdown by tumor microenvironment-responsive nanoparticles remodels the cytokine profile and eradicates aggressive breast cancer cells.
4083,9891,38692174,10.1016/j.colsurfb.2024.113930,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MCT4 knockdown by tumor microenvironment-responsive nanoparticles remodels the cytokine profile and eradicates aggressive breast cancer cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,MCT4 knockdown by tumor microenvironment-responsive nanoparticles remodels the cytokine profile and eradicates aggressive breast cancer cells.
4085,9895,38682294,10.1039/d3tb02766j,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticles as the drug carrier for targeted therapy of hepatic disorders.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles as the drug carrier for targeted therapy of hepatic disorders.
4086,9906,38646148,10.1080/14686996.2024.2338785,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Fine tuning of the net charge alternation of polyzwitterion surfaced lipid nanoparticles to enhance cellular uptake and membrane fusion potential.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Fine tuning of the net charge alternation of polyzwitterion surfaced lipid nanoparticles to enhance cellular uptake and membrane fusion potential.
4087,9909,38641228,10.1016/j.ejpb.2024.114297,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Spray-drying of PEI-/PPI-based nanoparticles for DNA or siRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Spray-drying of PEI-/PPI-based nanoparticles for DNA or siRNA delivery.
4092,9920,38621638,10.1016/j.jconrel.2024.04.022,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticle-based strategies for extrahepatic delivery of nucleic acid therapies - challenges and opportunities.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle-based strategies for extrahepatic delivery of nucleic acid therapies - challenges and opportunities.
4094,9926,38613388,10.1093/nar/gkae260,chemistry,siRNA,PubMed abstract sentence 3,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.
4096,9932,38607350,10.1080/00498254.2024.2339983,chemistry,ASO,PubMed abstract sentence 2,chemical;conjugate,"chemistry candidate; matched derived terms: chemical, conjugate; source title: Bioanalytical approaches to support the development of antibody-oligonucleotide conjugate (AOC) therapeutic proteins.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Bioanalytical approaches to support the development of antibody-oligonucleotide conjugate (AOC) therapeutic proteins.
4097,9933,38607350,10.1080/00498254.2024.2339983,delivery,ASO,PubMed abstract sentence 2,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Bioanalytical approaches to support the development of antibody-oligonucleotide conjugate (AOC) therapeutic proteins.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Bioanalytical approaches to support the development of antibody-oligonucleotide conjugate (AOC) therapeutic proteins.
4098,9936,38588455,10.1021/acs.jpcb.3c07600,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Ionizable Lipids from Click Reactions for Lipid Nanoparticle Assembling and mRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ionizable Lipids from Click Reactions for Lipid Nanoparticle Assembling and mRNA Delivery.
4101,9943,38583092,10.1001/jamacardio.2024.0959,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Plozasiran (ARO-APOC3) for Severe Hypertriglyceridemia: The SHASTA-2 Randomized Clinical Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Plozasiran (ARO-APOC3) for Severe Hypertriglyceridemia: The SHASTA-2 Randomized Clinical Trial.
4102,9946,38577851,10.1039/d3tb02827e,delivery,siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment.
4104,9950,38576454,10.1016/j.omtn.2024.102175,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system.
4108,9956,38567845,10.1021/acsnano.3c09028,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance.
4115,9975,38521952,10.1186/s13578-024-01206-8,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc.
4116,9978,38514018,10.1016/j.addr.2024.115291,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipid nanoparticles for RNA delivery: Self-assembling vs driven-assembling strategies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles for RNA delivery: Self-assembling vs driven-assembling strategies.
4118,9982,38513098,10.1073/pnas.2319856121,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation.
4124,9992,38487970,10.1002/jbm.a.37705,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length.
4126,9996,38477058,10.1021/acs.nanolett.3c03345,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Selective Replacement of Cholesterol with Cationic Amphiphilic Drugs Enables the Design of Lipid Nanoparticles with Improved RNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Selective Replacement of Cholesterol with Cationic Amphiphilic Drugs Enables the Design of Lipid Nanoparticles with Improved RNA Delivery.
4128,10006,38437543,10.1073/pnas.2307809121,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp, uptake; source title: Electrostatic adsorption of polyanions onto lipid nanoparticles controls uptake, trafficking, and transfection of RNA and DNA therapies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Electrostatic adsorption of polyanions onto lipid nanoparticles controls uptake, trafficking, and transfection of RNA and DNA therapies."
4131,10013,38417704,10.1016/j.ejpb.2024.114238,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Development of cationic solid lipid nanoparticles incorporating cholesteryl-9-carboxynonanoate (9CCN) for delivery of antagomiRs to macrophages.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of cationic solid lipid nanoparticles incorporating cholesteryl-9-carboxynonanoate (9CCN) for delivery of antagomiRs to macrophages.
4133,10017,38416311,10.1007/s11910-024-01335-0,assay,ASO/siRNA,PubMed abstract sentence 6,preclinical;model;trial,"assay candidate; matched derived terms: preclinical, model, trial; source title: Recent Advances in Clinical Trials in Multiple System Atrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent Advances in Clinical Trials in Multiple System Atrophy.
4135,10025,38381344,10.1007/978-1-0716-3678-7_14,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Encapsulating In Vitro Transcribed circRNA into Lipid Nanoparticles Via Microfluidic Mixing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Encapsulating In Vitro Transcribed circRNA into Lipid Nanoparticles Via Microfluidic Mixing.
4136,10030,38375188,10.1016/j.cccb.2024.100211,assay,ASO/siRNA,PubMed abstract sentence 5,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: A multicenter, single-arm, phase II clinical trial of adrenomedullin in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A multicenter, single-arm, phase II clinical trial of adrenomedullin in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy."
4138,10034,38369021,10.1016/j.xphs.2024.02.017,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pharmaceutical Nanoplatforms Based on Self-nanoemulsifying Drug Delivery Systems for Optimal Transport and Co-delivery of siRNAs and Anticancer Drugs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pharmaceutical Nanoplatforms Based on Self-nanoemulsifying Drug Delivery Systems for Optimal Transport and Co-delivery of siRNAs and Anticancer Drugs.
4145,10047,38330721,10.1016/j.bioorg.2024.107176,assay,ASO,PubMed abstract sentence 2,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Repurposing sodium stibogluconate as an uracil DNA glycosylase inhibitor against prostate cancer using a time-resolved oligonucleotide-based drug screening platform.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Repurposing sodium stibogluconate as an uracil DNA glycosylase inhibitor against prostate cancer using a time-resolved oligonucleotide-based drug screening platform.
4148,10054,38311577,10.1002/advs.202308345,assay,siRNA,PubMed abstract sentence 3,model;rna-seq,"assay candidate; matched derived terms: model, rna-seq; source title: Identification of Potent siRNA Delivery Peptides Using Computer Modeling.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of Potent siRNA Delivery Peptides Using Computer Modeling.
4158,10078,38197438,10.1039/d3nr05738k,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cellular uptake and fate of cationic polymer-coated nanodiamonds delivering siRNA: a mechanistic study.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cellular uptake and fate of cationic polymer-coated nanodiamonds delivering siRNA: a mechanistic study.
4162,10086,38191947,10.1208/s12249-023-02728-z,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development and Characterization of Modified Chitosan Lipopolyplex for an Effective siRNA Delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development and Characterization of Modified Chitosan Lipopolyplex for an Effective siRNA Delivery.
4166,10094,38126895,10.1002/smll.202308775,delivery,siRNA,PubMed abstract sentence 9,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis.
4167,10095,38126895,10.1002/smll.202308775,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis.
4168,10098,38065313,10.1016/j.ejpb.2023.11.025,delivery,ASO/siRNA,PubMed abstract sentence 5,lnp;uptake,"delivery candidate; matched derived terms: lnp, uptake; source title: Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity.
4170,10102,38043928,10.1002/jgm.3642,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Surface modification of lipid nanoparticles for gene therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Surface modification of lipid nanoparticles for gene therapy.
4175,10119,39850578,10.1089/genbio.2023.0045,chemistry,ASO/siRNA,PubMed abstract sentence 5,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: In Vivo Prime Editing by Lipid Nanoparticle Co-delivery of Chemically Modified pegRNA and Prime Editor mRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vivo Prime Editing by Lipid Nanoparticle Co-delivery of Chemically Modified pegRNA and Prime Editor mRNA.
4176,10120,39850578,10.1089/genbio.2023.0045,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: In Vivo Prime Editing by Lipid Nanoparticle Co-delivery of Chemically Modified pegRNA and Prime Editor mRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vivo Prime Editing by Lipid Nanoparticle Co-delivery of Chemically Modified pegRNA and Prime Editor mRNA.
4177,10121,39850578,10.1089/genbio.2023.0045,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In Vivo Prime Editing by Lipid Nanoparticle Co-delivery of Chemically Modified pegRNA and Prime Editor mRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In Vivo Prime Editing by Lipid Nanoparticle Co-delivery of Chemically Modified pegRNA and Prime Editor mRNA.
4185,10141,37963105,10.1021/acs.molpharmaceut.3c00455,delivery,siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Impact of Peptide Sequence on Functional siRNA Delivery and Gene Knockdown with Cyclic Amphipathic Peptide Delivery Agents.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Impact of Peptide Sequence on Functional siRNA Delivery and Gene Knockdown with Cyclic Amphipathic Peptide Delivery Agents.
4194,10166,37797162,10.1089/nat.2023.0003,offtarget,siRNA,PubMed abstract sentence 2,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Development of Long Asymmetric siRNA Structure for Target Gene Silencing and Immune Stimulation in Mammalian Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of Long Asymmetric siRNA Structure for Target Gene Silencing and Immune Stimulation in Mammalian Cells.
4195,10171,37759475,10.3390/cells12182253,chemistry,ASO,PubMed abstract sentence 3,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking.
4196,10174,37741808,10.1007/s11033-023-08749-y,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities.
4199,10179,37734448,10.1039/d3bm01115a,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery of siRNA using cationic rosette nanotubes for gene silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery of siRNA using cationic rosette nanotubes for gene silencing.
4202,10186,37644723,10.1016/j.ymthe.2023.08.016,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: MicroRNA137-loaded lipid nanoparticles regulate synaptic proteins in the prefrontal cortex.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MicroRNA137-loaded lipid nanoparticles regulate synaptic proteins in the prefrontal cortex.
4203,10189,37631003,10.3390/ph16081088,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,From Bench to Bedside: Implications of Lipid Nanoparticle Carrier Reactogenicity for Advancing Nucleic Acid Therapeutics.
4208,10204,37459141,10.1001/jama.2023.13239,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.
4209,10207,37364130,10.1073/pnas.2301067120,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm.
4211,10211,37355556,10.1007/978-1-0716-3331-1_24,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid Nanoparticle-Mediated Delivery of miRNA Mimics to Myeloid Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticle-Mediated Delivery of miRNA Mimics to Myeloid Cells.
4213,10215,37317010,10.1002/smtd.202201695,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Understanding Intracellular Biology to Improve mRNA Delivery by Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Understanding Intracellular Biology to Improve mRNA Delivery by Lipid Nanoparticles.
4215,10219,37310997,10.1073/pnas.2215711120,delivery,siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy.
4218,10226,37276899,10.1016/j.ijbiomac.2023.125185,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Current state of RNA delivery using lipid nanoparticles to extrahepatic tissues: A review towards clinical translation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Current state of RNA delivery using lipid nanoparticles to extrahepatic tissues: A review towards clinical translation.
4224,10238,37221913,10.1039/d3tb00308f,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Next-generation materials for RNA-lipid nanoparticles: lyophilization and targeted transfection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Next-generation materials for RNA-lipid nanoparticles: lyophilization and targeted transfection.
4226,10246,37171801,10.1002/advs.202301377,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38-Targeted Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of Therapeutic RNA to the Bone Marrow in Multiple Myeloma Using CD38-Targeted Lipid Nanoparticles.
4234,10266,37092557,10.1002/advs.202301929,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A Combinatorial Library of Lipid Nanoparticles for Cell Type-Specific mRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Combinatorial Library of Lipid Nanoparticles for Cell Type-Specific mRNA Delivery.
4235,10267,37092557,10.1002/advs.202301929,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Combinatorial Library of Lipid Nanoparticles for Cell Type-Specific mRNA Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Combinatorial Library of Lipid Nanoparticles for Cell Type-Specific mRNA Delivery.
4237,10273,37075200,10.1021/jacs.3c01032,delivery,siRNA,PubMed abstract sentence 1,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Ratiometric, pH-Sensitive Probe for Monitoring siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Ratiometric, pH-Sensitive Probe for Monitoring siRNA Delivery."
4242,10290,37028451,10.1016/j.jconrel.2023.04.005,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo.
4245,10295,37016578,10.1016/j.ymthe.2023.03.036,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Red blood cell extracellular vesicles deliver therapeutic siRNAs to skeletal muscles for treatment of cancer cachexia.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Red blood cell extracellular vesicles deliver therapeutic siRNAs to skeletal muscles for treatment of cancer cachexia.
4248,10302,36881759,10.1093/nar/gkad067,chemistry,ASO,PubMed abstract sentence 5,modification;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: modification, phosphorothioate, 2'-o; source title: Chemistry, structure and function of approved oligonucleotide therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Chemistry, structure and function of approved oligonucleotide therapeutics."
4258,10326,36721963,10.1111/all.15663,assay,siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Treatment of COVID-19 patients with a SARS-CoV-2-specific siRNA-peptide dendrimer formulation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Treatment of COVID-19 patients with a SARS-CoV-2-specific siRNA-peptide dendrimer formulation.
4259,10329,36696009,10.1007/s12035-023-03236-8,assay,ASO,PubMed abstract sentence 5,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Posttranscriptional Regulation of Gene Expression Participates in the Myelin Restoration in Mouse Models of Multiple Sclerosis: Antisense Modulation of HuR and HuD ELAV RNA Binding Protein.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Posttranscriptional Regulation of Gene Expression Participates in the Myelin Restoration in Mouse Models of Multiple Sclerosis: Antisense Modulation of HuR and HuD ELAV RNA Binding Protein.
4262,10338,36650129,10.1038/s41467-022-35637-z,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis.
4265,10345,36603692,10.1016/j.ejpb.2022.12.017,delivery,siRNA,PubMed abstract sentence 6,conjugated;uptake,"delivery candidate; matched derived terms: conjugated, uptake; source title: Multivalent mannose-conjugated siRNA causes robust gene silencing in pancreatic macrophages in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multivalent mannose-conjugated siRNA causes robust gene silencing in pancreatic macrophages in vivo.
4267,10349,36588456,10.1080/17425247.2023.2162876,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Why mRNA-ionizable LNPs formulations are so short-lived: causes and way-out.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Why mRNA-ionizable LNPs formulations are so short-lived: causes and way-out.
4268,10354,36546308,10.1080/17460441.2022.2157399,chemistry,ASO,PubMed abstract sentence 3,modified;conjugate,"chemistry candidate; matched derived terms: modified, conjugate; source title: Reality check: lipid-oligonucleotide conjugates for therapeutic applications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Reality check: lipid-oligonucleotide conjugates for therapeutic applications.
4275,10373,36336817,10.1002/bdd.2338,delivery,ASO,PubMed abstract sentence 6,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Biodistribution and delivery of oligonucleotide therapeutics to the central nervous system: Advances, challenges, and future perspectives.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Biodistribution and delivery of oligonucleotide therapeutics to the central nervous system: Advances, challenges, and future perspectives."
4281,10383,36269327,10.1089/nat.2022.0021,chemistry,siRNA,PubMed abstract sentence 3,chemical;modified;conjugate,"chemistry candidate; matched derived terms: chemical, modified, conjugate; source title: Efficient Downregulation of Alk4 in Skeletal Muscle After Systemic Treatment with Conjugated siRNAs in a Mouse Model for Duchenne Muscular Dystrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient Downregulation of Alk4 in Skeletal Muscle After Systemic Treatment with Conjugated siRNAs in a Mouse Model for Duchenne Muscular Dystrophy.
4282,10384,36269327,10.1089/nat.2022.0021,delivery,siRNA,PubMed abstract sentence 3,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Efficient Downregulation of Alk4 in Skeletal Muscle After Systemic Treatment with Conjugated siRNAs in a Mouse Model for Duchenne Muscular Dystrophy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient Downregulation of Alk4 in Skeletal Muscle After Systemic Treatment with Conjugated siRNAs in a Mouse Model for Duchenne Muscular Dystrophy.
4285,10391,35014835,10.1021/acsabm.1c00732,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Microfluidics for Development of Lipid Nanoparticles: Paving the Way for Nucleic Acids to the Clinic.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Microfluidics for Development of Lipid Nanoparticles: Paving the Way for Nucleic Acids to the Clinic.
4288,10400,36438494,10.7150/thno.77259,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging.
4290,10404,36411594,10.1080/15476286.2022.2147278,chemistry,ASO,PubMed abstract sentence 3,modification;modified,"chemistry candidate; matched derived terms: modification, modified; source title: Evolution of complexity in non-viral oligonucleotide delivery systems: from gymnotic delivery through bioconjugates to biomimetic nanoparticles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evolution of complexity in non-viral oligonucleotide delivery systems: from gymnotic delivery through bioconjugates to biomimetic nanoparticles.
4291,10405,36411594,10.1080/15476286.2022.2147278,delivery,ASO,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Evolution of complexity in non-viral oligonucleotide delivery systems: from gymnotic delivery through bioconjugates to biomimetic nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evolution of complexity in non-viral oligonucleotide delivery systems: from gymnotic delivery through bioconjugates to biomimetic nanoparticles.
4293,10409,36367350,10.1021/acs.langmuir.2c01492,chemistry,ASO/siRNA,PubMed abstract sentence 6,chemical;modification;phosphorothioate,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate; source title: On the Influence of Nucleic Acid Backbone Modifications on Lipid Nanoparticle Morphology.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,On the Influence of Nucleic Acid Backbone Modifications on Lipid Nanoparticle Morphology.
4294,10410,36367350,10.1021/acs.langmuir.2c01492,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: On the Influence of Nucleic Acid Backbone Modifications on Lipid Nanoparticle Morphology.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,On the Influence of Nucleic Acid Backbone Modifications on Lipid Nanoparticle Morphology.
4296,10414,36365241,10.3390/pharmaceutics14112424,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells.
4297,10419,36276652,10.7150/thno.77830,offtarget,ASO,PubMed abstract sentence 8,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: Specificity of oligonucleotide gene therapy (OGT) agents.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Specificity of oligonucleotide gene therapy (OGT) agents.
4298,10424,36229710,10.1007/s10555-022-10066-y,assay,ASO/siRNA,PubMed abstract sentence 8,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: The race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options.
4305,10437,36149091,10.1021/acsami.2c09406,delivery,siRNA,PubMed abstract sentence 5,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Artificial Nucleobase-Directed Programmable Synthesis and Assembly of Amphiphilic Nucleic Acids as an All-in-One Platform for Cation-Free siRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Artificial Nucleobase-Directed Programmable Synthesis and Assembly of Amphiphilic Nucleic Acids as an All-in-One Platform for Cation-Free siRNA Delivery.
4306,10438,36149091,10.1021/acsami.2c09406,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Artificial Nucleobase-Directed Programmable Synthesis and Assembly of Amphiphilic Nucleic Acids as an All-in-One Platform for Cation-Free siRNA Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Artificial Nucleobase-Directed Programmable Synthesis and Assembly of Amphiphilic Nucleic Acids as an All-in-One Platform for Cation-Free siRNA Delivery.
4308,10444,36064365,10.1186/s12951-022-01603-6,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hydrogel-metal-organic-framework hybrids mediated efficient oral delivery of siRNA for the treatment of ulcerative colitis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hydrogel-metal-organic-framework hybrids mediated efficient oral delivery of siRNA for the treatment of ulcerative colitis.
4312,10456,35847173,10.1016/j.omtn.2022.06.009,chemistry,siRNA,PubMed abstract sentence 4,chemical;modification;conjugate,"chemistry candidate; matched derived terms: chemical, modification, conjugate; source title: Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.",B,high_candidate,curator_verified,accept,derived_annotations_only,Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.
4316,10468,35745067,10.3390/molecules27123944,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes.
4317,10473,35723475,10.3791/63877,chemistry,ASO,PubMed abstract sentence 4,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Chemical Triphosphorylation of Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical Triphosphorylation of Oligonucleotides.
4321,10485,35525599,10.1016/j.aca.2022.339778,chemistry,ASO/siRNA,PubMed abstract sentence 7,modified;lna,"chemistry candidate; matched derived terms: modified, lna; source title: Highly sensitive fluorescence multiplexed miRNAs biosensors for accurate clinically diagnosis lung cancer disease using LNA-modified DNA probe and DSN enzyme.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Highly sensitive fluorescence multiplexed miRNAs biosensors for accurate clinically diagnosis lung cancer disease using LNA-modified DNA probe and DSN enzyme.
4329,10505,35362323,10.1021/acs.biomac.1c01497,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Surface-Functionalized Polymeric siRNA Nanoparticles for Tunable Targeting and Intracellular Delivery to Hematologic Cancer Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Surface-Functionalized Polymeric siRNA Nanoparticles for Tunable Targeting and Intracellular Delivery to Hematologic Cancer Cells.
4331,10509,35358374,10.1002/adma.202200839,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Coupling Lipid Nanoparticle Structure and Automated Single-Particle Composition Analysis to Design Phospholipase-Responsive Nanocarriers.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Coupling Lipid Nanoparticle Structure and Automated Single-Particle Composition Analysis to Design Phospholipase-Responsive Nanocarriers.
4341,10539,35037525,10.1080/10717544.2022.2026532,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Utilizing RNA nanotechnology to construct negatively charged and ultrasound-responsive nanodroplets for targeted delivery of siRNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Utilizing RNA nanotechnology to construct negatively charged and ultrasound-responsive nanodroplets for targeted delivery of siRNA.
4342,10546,35020348,10.1021/acschembio.1c00652,chemistry,siRNA,PubMed abstract sentence 3,chemical;modified;conjugate,"chemistry candidate; matched derived terms: chemical, modified, conjugate; source title: Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand-siRNA Conjugates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand-siRNA Conjugates.
4343,10547,35020348,10.1021/acschembio.1c00652,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand-siRNA Conjugates.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand-siRNA Conjugates.
4345,10553,34919890,10.1016/j.ejphar.2021.174639,delivery,siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Simultaneous nanocarrier-mediated delivery of siRNAs and chemotherapeutic agents in cancer therapy and diagnosis: Recent advances.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Simultaneous nanocarrier-mediated delivery of siRNAs and chemotherapeutic agents in cancer therapy and diagnosis: Recent advances.
4346,10554,34919890,10.1016/j.ejphar.2021.174639,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Simultaneous nanocarrier-mediated delivery of siRNAs and chemotherapeutic agents in cancer therapy and diagnosis: Recent advances.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Simultaneous nanocarrier-mediated delivery of siRNAs and chemotherapeutic agents in cancer therapy and diagnosis: Recent advances.
4347,10559,34742747,10.1016/j.jconrel.2021.10.031,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery.
4351,10567,34382360,10.1002/adhm.202101202,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles.
4352,10568,34382360,10.1002/adhm.202101202,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles.
4354,10572,34959463,10.3390/pharmaceutics13122182,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Non-Cationic RGD-Containing Protein Nanocarrier for Tumor-Targeted siRNA Delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Non-Cationic RGD-Containing Protein Nanocarrier for Tumor-Targeted siRNA Delivery.
4357,10583,34852217,10.1016/j.immuni.2021.11.001,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses.
4360,10590,34841414,10.1021/jacsau.1c00327,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers.
4364,10602,34650390,10.1002/adfm.202009768,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy.
4373,10631,34437914,10.1016/j.jconrel.2021.08.039,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy.
4374,10632,34437914,10.1016/j.jconrel.2021.08.039,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy.
4378,10646,34297902,10.1089/nat.2021.0026,toxicity,siRNA,PubMed abstract sentence 2,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease.
4397,10693,33952251,10.1186/s12951-021-00869-6,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing.
4400,10708,33791329,10.3389/fmed.2021.643028,assay,ASO/siRNA,PubMed abstract sentence 6,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Sex Proportionality in Pre-clinical and Clinical Trials: An Evaluation of 22 Marketing Authorization Application Dossiers Submitted to the European Medicines Agency.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Sex Proportionality in Pre-clinical and Clinical Trials: An Evaluation of 22 Marketing Authorization Application Dossiers Submitted to the European Medicines Agency.
4401,10711,33774114,10.1016/j.addr.2021.03.009,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid nanoparticle formulations for targeting leukocytes with therapeutic RNA in liver fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle formulations for targeting leukocytes with therapeutic RNA in liver fibrosis.
4406,10720,33753161,10.1016/j.ijpharm.2021.120504,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Encapsulation of a CpG oligonucleotide in cationic liposomes enhances its local antitumor activity following pulmonary delivery in a murine model of metastatic lung cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Encapsulation of a CpG oligonucleotide in cationic liposomes enhances its local antitumor activity following pulmonary delivery in a murine model of metastatic lung cancer.
4408,10724,33744469,10.1016/j.ymthe.2021.03.015,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo.
4411,10731,33713664,10.1016/j.lfs.2021.119337,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle;galnac;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, galnac, lnp; source title: Advances in siRNA delivery strategies for the treatment of MDR cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in siRNA delivery strategies for the treatment of MDR cancer.
4412,10732,33713664,10.1016/j.lfs.2021.119337,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advances in siRNA delivery strategies for the treatment of MDR cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in siRNA delivery strategies for the treatment of MDR cancer.
4414,10740,33637537,10.1126/sciadv.abf4398,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver.
4417,10747,33595381,10.1089/nat.2020.0882,delivery,siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Folate Receptor-Mediated siRNA Delivery: Recent Developments and Future Directions for RNAi Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Folate Receptor-Mediated siRNA Delivery: Recent Developments and Future Directions for RNAi Therapeutics.
4419,10753,33548256,10.1016/j.exer.2021.108482,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: RNA therapeutics in ophthalmology - translation to clinical trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA therapeutics in ophthalmology - translation to clinical trials.
4420,10756,33496597,10.1021/acs.molpharmaceut.0c00969,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Peptide/Lipid-Associated Nucleic Acids (PLANAs) as a Multicomponent siRNA Delivery System.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Peptide/Lipid-Associated Nucleic Acids (PLANAs) as a Multicomponent siRNA Delivery System.
4421,10757,33496597,10.1021/acs.molpharmaceut.0c00969,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Peptide/Lipid-Associated Nucleic Acids (PLANAs) as a Multicomponent siRNA Delivery System.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Peptide/Lipid-Associated Nucleic Acids (PLANAs) as a Multicomponent siRNA Delivery System.
4429,10775,33404020,10.1039/d0bm01609h,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver.
4433,10787,33375375,10.3390/ijms22010182,chemistry,ASO,PubMed abstract sentence 3,2'-o;conjugate,"chemistry candidate; matched derived terms: 2'-o, conjugate; source title: Terminal Mono- and Bis-Conjugates of Oligonucleotides with Closo-Dodecaborate: Synthesis and Physico-Chemical Properties.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Terminal Mono- and Bis-Conjugates of Oligonucleotides with Closo-Dodecaborate: Synthesis and Physico-Chemical Properties.
4436,10792,33374392,10.3390/ijms22010121,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tuning G-Quadruplex Nanostructures with Lipids. Towards Designing Hybrid Scaffolds for Oligonucleotide Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tuning G-Quadruplex Nanostructures with Lipids. Towards Designing Hybrid Scaffolds for Oligonucleotide Delivery.
4446,10824,32726663,10.1016/j.lfs.2020.118150,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib.
4448,10830,32597264,10.1080/03639045.2020.1788061,delivery,ASO,PubMed abstract sentence 13,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Development of orally administered insulin-loaded polymeric-oligonucleotide nanoparticles: statistical optimization and physicochemical characterization.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of orally administered insulin-loaded polymeric-oligonucleotide nanoparticles: statistical optimization and physicochemical characterization.
4457,10855,32182035,10.1021/acsami.9b22781,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Microfluidic-Based Holonomic Constraints of siRNA in the Kernel of Lipid/Polymer Hybrid Nanoassemblies for Improving Stable and Safe In Vivo Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Microfluidic-Based Holonomic Constraints of siRNA in the Kernel of Lipid/Polymer Hybrid Nanoassemblies for Improving Stable and Safe In Vivo Delivery.
4458,10858,32059541,10.3390/biom10020285,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth.
4461,10863,32010914,10.1039/c9tb02764e,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Stimuli-responsive release and efficient siRNA delivery in non-small cell lung cancer by a poly(l-histidine)-based multifunctional nanoplatform.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Stimuli-responsive release and efficient siRNA delivery in non-small cell lung cancer by a poly(l-histidine)-based multifunctional nanoplatform.
4462,10864,32010914,10.1039/c9tb02764e,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Stimuli-responsive release and efficient siRNA delivery in non-small cell lung cancer by a poly(l-histidine)-based multifunctional nanoplatform.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Stimuli-responsive release and efficient siRNA delivery in non-small cell lung cancer by a poly(l-histidine)-based multifunctional nanoplatform.
4463,10867,32006400,10.1007/978-1-0716-0290-4_9,offtarget,siRNA,PubMed abstract sentence 1,off-target;unintended;silencing,"offtarget candidate; matched derived terms: off-target, unintended, silencing; source title: Exploring 5'-Biotinylation of the Sense Strand to Improve siRNA Specificity and Potency.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Exploring 5'-Biotinylation of the Sense Strand to Improve siRNA Specificity and Potency.
4464,10872,31990567,10.1021/acs.molpharmaceut.9b01182,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution.
4466,10878,31789134,10.2174/1574888X14666191202095041,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanocarrier Mediated siRNA Delivery Targeting Stem Cell Differentiation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanocarrier Mediated siRNA Delivery Targeting Stem Cell Differentiation.
4469,10889,31676815,10.1038/s41598-019-52142-4,delivery,siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Therapeutic potential of functionalized siRNA nanoparticles on regression of liver cancer in experimental mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic potential of functionalized siRNA nanoparticles on regression of liver cancer in experimental mice.
4470,10890,31676815,10.1038/s41598-019-52142-4,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Therapeutic potential of functionalized siRNA nanoparticles on regression of liver cancer in experimental mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Therapeutic potential of functionalized siRNA nanoparticles on regression of liver cancer in experimental mice.
4471,10893,31629036,10.1016/j.jconrel.2019.09.011,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice.
4472,10894,31629036,10.1016/j.jconrel.2019.09.011,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice.
4477,10907,31479430,10.1172/JCI128205,delivery,ASO,PubMed abstract sentence 4,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice.
4479,10911,31375812,10.1038/s41587-019-0205-0,chemistry,siRNA,PubMed abstract sentence 3,chemical;modified;phosphorothioate,"chemistry candidate; matched derived terms: chemical, modified, phosphorothioate; source title: A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
4480,10914,30917503,10.3390/molecules24061180,chemistry,ASO,PubMed abstract sentence 1,phosphorothioate;conjugate,"chemistry candidate; matched derived terms: phosphorothioate, conjugate; source title: Oligonucleotide⁻Palladacycle Conjugates as Splice-Correcting Agents.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oligonucleotide⁻Palladacycle Conjugates as Splice-Correcting Agents.
4484,10928,30388622,10.1016/j.omtn.2018.09.027,chemistry,ASO,PubMed abstract sentence 1,chemical;modified;phosphorothioate;2'-o;conjugate,"chemistry candidate; matched derived terms: chemical, modified, phosphorothioate, 2'-o, conjugate; source title: Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids.
4489,10939,29860520,10.1093/nar/gky437,offtarget,siRNA,PubMed abstract sentence 3,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis."
4490,10942,29858079,10.1016/j.omtn.2018.02.005,chemistry,ASO,PubMed abstract sentence 7,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo.
4491,10943,29858079,10.1016/j.omtn.2018.02.005,delivery,ASO,PubMed abstract sentence 7,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo.
4495,10953,29439147,10.2337/dc17-2132,assay,ASO,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1B(Rx) Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense Inhibition of Protein Tyrosine Phosphatase 1B With IONIS-PTP-1B(Rx) Improves Insulin Sensitivity and Reduces Weight in Overweight Patients With Type 2 Diabetes.
4497,10963,29246303,10.1016/j.omtn.2017.10.003,chemistry,siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Site-Specific Modification Using the 2'-Methoxyethyl Group Improves the Specificity and Activity of siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Site-Specific Modification Using the 2'-Methoxyethyl Group Improves the Specificity and Activity of siRNAs.
4500,10972,28742140,10.1371/journal.pone.0181065,chemistry,ASO,PubMed abstract sentence 3,chemical;modified;lna,"chemistry candidate; matched derived terms: chemical, modified, lna; source title: Short (16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Short (16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes.
4503,10977,28633548,10.1080/10717544.2017.1337827,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Polyquaternium-mediated delivery of morpholino oligonucleotides for exon-skipping in vitro and in mdx mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Polyquaternium-mediated delivery of morpholino oligonucleotides for exon-skipping in vitro and in mdx mice.
4508,10996,26964641,10.1038/ncomms10981,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice.
4509,10999,26944796,10.1016/j.biochi.2016.02.015,chemistry,siRNA,PubMed abstract sentence 4,modification;2'-o,"chemistry candidate; matched derived terms: modification, 2'-o; source title: Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells.
4510,11002,26923600,10.1016/j.celrep.2016.02.018,chemistry,ASO,PubMed abstract sentence 3,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases.
4511,11007,26318819,10.1016/j.biomaterials.2015.07.055,chemistry,ASO/siRNA,PubMed abstract sentence 2,modified;lna,"chemistry candidate; matched derived terms: modified, lna; source title: LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging."
4515,11013,26134311,10.1039/c5nr01665g,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Dendritic nanoconjugates for intracellular delivery of neutral oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dendritic nanoconjugates for intracellular delivery of neutral oligonucleotides.
4516,11016,26051465,10.1021/acsnano.5b01203,chemistry,siRNA,PubMed abstract sentence 10,modification;2'-o,"chemistry candidate; matched derived terms: modification, 2'-o; source title: Construction of an Aptamer-SiRNA Chimera-Modified Tissue-Engineered Blood Vessel for Cell-Type-Specific Capture and Delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Construction of an Aptamer-SiRNA Chimera-Modified Tissue-Engineered Blood Vessel for Cell-Type-Specific Capture and Delivery.
4519,11023,25915865,10.1371/journal.pone.0125494,chemistry,ASO/siRNA,PubMed abstract sentence 5,phosphorothioate;lna,"chemistry candidate; matched derived terms: phosphorothioate, lna; source title: Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes.
4521,11029,25692975,10.1038/ncomms7280,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo.
4522,11034,25434769,10.1021/ja505986a,chemistry,siRNA,PubMed abstract sentence 7,chemical;modified;galnac;lna;conjugate,"chemistry candidate; matched derived terms: chemical, modified, galnac, lna, conjugate; source title: Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.
4523,11035,25434769,10.1021/ja505986a,delivery,siRNA,PubMed abstract sentence 1,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.
4527,11045,24586944,10.1371/journal.pone.0089659,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;phosphorothioate;lna,"chemistry candidate; matched derived terms: modified, phosphorothioate, lna; source title: In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.
4530,11054,24405395,10.1089/hum.2013.156,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluation of Tris[2-(acryloyloxy)ethyl]isocyanurate cross-linked polyethylenimine as antisense morpholino oligomer delivery vehicle in cell culture and dystrophic mdx mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Evaluation of Tris[2-(acryloyloxy)ethyl]isocyanurate cross-linked polyethylenimine as antisense morpholino oligomer delivery vehicle in cell culture and dystrophic mdx mice.
4535,11065,24065781,10.1093/intimm/dxt040,chemistry,siRNA,PubMed abstract sentence 6,modified;2'-o,"chemistry candidate; matched derived terms: modified, 2'-o; source title: Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro.
4539,11071,23740874,10.1002/jbio.201300056,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Plasmonic laser treatment for Morpholino oligomer delivery in antisense applications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Plasmonic laser treatment for Morpholino oligomer delivery in antisense applications.
4540,11074,24278398,10.1371/journal.pone.0081230,chemistry,ASO/siRNA,PubMed abstract sentence 5,phosphorothioate;2'-o;lna,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o, lna; source title: Hybridization-based detection of Helicobacter pylori at human body temperature using advanced locked nucleic acid (LNA) probes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hybridization-based detection of Helicobacter pylori at human body temperature using advanced locked nucleic acid (LNA) probes.
4543,11085,23876758,10.1016/j.biomaterials.2013.06.066,delivery,ASO,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides.
4544,11086,23876758,10.1016/j.biomaterials.2013.06.066,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides.
4546,11094,23140454,10.2174/1381612811319160009,delivery,ASO,PubMed abstract sentence 6,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Cell penetrating peptide delivery of splice directing oligonucleotides as a treatment for Duchenne muscular dystrophy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cell penetrating peptide delivery of splice directing oligonucleotides as a treatment for Duchenne muscular dystrophy.
4547,11095,23140454,10.2174/1381612811319160009,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cell penetrating peptide delivery of splice directing oligonucleotides as a treatment for Duchenne muscular dystrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cell penetrating peptide delivery of splice directing oligonucleotides as a treatment for Duchenne muscular dystrophy.
4548,11098,23344622,10.1038/mtna.2011.4,chemistry,siRNA,PubMed abstract sentence 1,modification;2'-o,"chemistry candidate; matched derived terms: modification, 2'-o; source title: siRNA-optimized Modifications for Enhanced In Vivo Activity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA-optimized Modifications for Enhanced In Vivo Activity.
4552,11106,22869723,10.1073/pnas.1204638109,toxicity,ASO,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bodywide skipping of exons 45-55 in dystrophic mdx52 mice by systemic antisense delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bodywide skipping of exons 45-55 in dystrophic mdx52 mice by systemic antisense delivery.
4553,11109,22852836,10.1089/nat.2012.0366,chemistry,ASO,PubMed abstract sentence 1,chemical;modified;2'-o;lna,"chemistry candidate; matched derived terms: chemical, modified, 2'-o, lna; source title: Chemical modification study of antisense gapmers.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical modification study of antisense gapmers.
4555,11113,22615794,10.1371/journal.pone.0036697,chemistry,ASO,PubMed abstract sentence 7,modified;phosphorothioate,"chemistry candidate; matched derived terms: modified, phosphorothioate; source title: Stable gene targeting in human cells using single-strand oligonucleotides with modified bases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Stable gene targeting in human cells using single-strand oligonucleotides with modified bases.
4556,11116,22505629,10.1124/jpet.112.193789,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response.
4557,11119,22287630,10.1093/nar/gks033,chemistry,siRNA,PubMed abstract sentence 6,modification;modified;lna,"chemistry candidate; matched derived terms: modification, modified, lna; source title: In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.
4558,11120,22287630,10.1093/nar/gks033,assay,siRNA,PubMed abstract sentence 2,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.
4559,11121,22287630,10.1093/nar/gks033,benchmark,siRNA,PubMed abstract sentence 4,model;challenge,"benchmark candidate; matched derived terms: model, challenge; source title: In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.
4560,11124,22246038,10.1182/blood-2011-10-387134,toxicity,ASO,PubMed abstract sentence 2,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys.
4568,11140,21556437,10.1039/c1cs15048k,chemistry,ASO/siRNA,PubMed abstract sentence 2,modification;modified;lna,"chemistry candidate; matched derived terms: modification, modified, lna; source title: Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals.
4571,11153,20886816,10.1021/ja105875e,chemistry,ASO/siRNA,PubMed abstract sentence 1,2'-o;lna,"chemistry candidate; matched derived terms: 2'-o, lna; source title: An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.
4574,11162,42080590,10.1093/bib/bbag206,benchmark,ASO/siRNA,PubMed abstract sentence 6,model;challenge,"benchmark candidate; matched derived terms: model, challenge; source title: Comprehensive evaluation of artificial intelligence-empowered approaches for protein-aptamer complex prediction.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comprehensive evaluation of artificial intelligence-empowered approaches for protein-aptamer complex prediction.
4583,11181,41076496,10.1007/s00256-025-05054-6,benchmark,ASO/siRNA,PubMed abstract sentence 10,model;dataset,"benchmark candidate; matched derived terms: model, dataset; source title: A proposed radiological model for preoperative chemotherapy response prediction in patients with skeletal Ewing sarcoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A proposed radiological model for preoperative chemotherapy response prediction in patients with skeletal Ewing sarcoma.
4595,11211,40169776,10.1038/s41598-025-93059-5,benchmark,ASO/siRNA,PubMed abstract sentence 13,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: An efficient graph attention framework enhances bladder cancer prediction.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,An efficient graph attention framework enhances bladder cancer prediction.
4601,11223,38918804,10.1186/s13019-024-02913-6,benchmark,ASO/siRNA,PubMed abstract sentence 3,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Construction of prediction models for novel subtypes in patients with arteriosclerosis obliterans undergoing endovascular therapy: an unsupervised machine learning study.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Construction of prediction models for novel subtypes in patients with arteriosclerosis obliterans undergoing endovascular therapy: an unsupervised machine learning study.
4604,11232,38373676,10.1016/j.fertnstert.2024.02.024,benchmark,ASO/siRNA,PubMed abstract sentence 1,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Prediction of pregnancy-related complications in women undergoing assisted reproduction, using machine learning methods.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Prediction of pregnancy-related complications in women undergoing assisted reproduction, using machine learning methods."
4605,11235,38204359,10.1093/database/baad096,chemistry,ASO/siRNA,PubMed abstract sentence 6,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: piOxi database: a web resource of germline and somatic tissue piRNAs identified by chemical oxidation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,piOxi database: a web resource of germline and somatic tissue piRNAs identified by chemical oxidation.
4613,11251,34978699,10.1007/978-1-0716-1952-0_17,assay,siRNA,PubMed abstract sentence 5,preclinical;experiment;phase;trial,"assay candidate; matched derived terms: preclinical, experiment, phase, trial; source title: Preclinical Research Strategy Development for RNAi-Based Therapies in Oncology Using Patient-Centered Information from Public Databases of Human Protein Atlas and R2Genomics Platform.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical Research Strategy Development for RNAi-Based Therapies in Oncology Using Patient-Centered Information from Public Databases of Human Protein Atlas and R2Genomics Platform.
4615,11255,33727685,10.1038/s41598-021-85629-0,benchmark,ASO/siRNA,PubMed abstract sentence 9,benchmark;dataset,"benchmark candidate; matched derived terms: benchmark, dataset; source title: AptaNet as a deep learning approach for aptamer-protein interaction prediction.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,AptaNet as a deep learning approach for aptamer-protein interaction prediction.
4618,11262,33344856,10.1021/acsomega.0c04931,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Experimentally Validated QSAR Model for Surface pK (a) Prediction of Heterolipids Having Potential as Delivery Materials for Nucleic Acid Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Experimentally Validated QSAR Model for Surface pK (a) Prediction of Heterolipids Having Potential as Delivery Materials for Nucleic Acid Therapeutics.
4619,11263,33344856,10.1021/acsomega.0c04931,assay,ASO/siRNA,PubMed abstract sentence 9,assay;model,"assay candidate; matched derived terms: assay, model; source title: Experimentally Validated QSAR Model for Surface pK (a) Prediction of Heterolipids Having Potential as Delivery Materials for Nucleic Acid Therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Experimentally Validated QSAR Model for Surface pK (a) Prediction of Heterolipids Having Potential as Delivery Materials for Nucleic Acid Therapeutics.
4621,11265,33344856,10.1021/acsomega.0c04931,benchmark,ASO/siRNA,PubMed abstract sentence 11,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Experimentally Validated QSAR Model for Surface pK (a) Prediction of Heterolipids Having Potential as Delivery Materials for Nucleic Acid Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Experimentally Validated QSAR Model for Surface pK (a) Prediction of Heterolipids Having Potential as Delivery Materials for Nucleic Acid Therapeutics.
4631,11313,42212620,10.3724/abbs.2026094,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Inhibition of the cGAS-STING pathway mitigates liver injury induced by docetaxel-carboplatin neoadjuvant chemotherapy via autophagy promotion.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of the cGAS-STING pathway mitigates liver injury induced by docetaxel-carboplatin neoadjuvant chemotherapy via autophagy promotion.
4634,11334,42210236,10.1186/s12943-026-02679-6,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting MORC2 activates transposable element-mediated viral mimicry and potentiates immune checkpoint blockade in triple-negative breast cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting MORC2 activates transposable element-mediated viral mimicry and potentiates immune checkpoint blockade in triple-negative breast cancer.
4636,11358,42208540,10.1016/j.ccell.2026.05.001,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting tumor-intrinsic STK40 induces immune vulnerability and drives T cell reinvigoration.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting tumor-intrinsic STK40 induces immune vulnerability and drives T cell reinvigoration.
4640,11384,42206582,10.1056/NEJMoa2515131,assay,ASO/siRNA,PubMed abstract sentence 11,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection.
4643,11411,42204133,10.1038/s41392-026-02671-y,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: LISS enables immune evasion of colorectal cancers irrespective of MSI status.",B,high_candidate,curator_rejected,reject,derived_annotations_only,LISS enables immune evasion of colorectal cancers irrespective of MSI status.
4647,11431,42203164,10.1016/j.ahj.2026.107493,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Design of VICTORION-2 Prevent: a randomized double-blind, placebo-controlled trial, assessing the impact of inclisiran on major adverse cardiovascular events in patients with established cardiovascular disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Design of VICTORION-2 Prevent: a randomized double-blind, placebo-controlled trial, assessing the impact of inclisiran on major adverse cardiovascular events in patients with established cardiovascular disease."
4648,11432,42203164,10.1016/j.ahj.2026.107493,toxicity,ASO/siRNA,PubMed abstract sentence 7,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Design of VICTORION-2 Prevent: a randomized double-blind, placebo-controlled trial, assessing the impact of inclisiran on major adverse cardiovascular events in patients with established cardiovascular disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Design of VICTORION-2 Prevent: a randomized double-blind, placebo-controlled trial, assessing the impact of inclisiran on major adverse cardiovascular events in patients with established cardiovascular disease."
4651,11457,42198283,10.3390/pharmaceutics18050589,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Synergistic Co-Delivery of siFGF2 and Doxorubicin via QTPlus Nanoparticles for Enhanced Breast Cancer Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synergistic Co-Delivery of siFGF2 and Doxorubicin via QTPlus Nanoparticles for Enhanced Breast Cancer Therapy.
4652,11458,42198283,10.3390/pharmaceutics18050589,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synergistic Co-Delivery of siFGF2 and Doxorubicin via QTPlus Nanoparticles for Enhanced Breast Cancer Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synergistic Co-Delivery of siFGF2 and Doxorubicin via QTPlus Nanoparticles for Enhanced Breast Cancer Therapy.
4663,11511,42193394,10.3390/biomedicines14051069,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: RNA-Loaded Nanoparticles for Targeted Lung Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA-Loaded Nanoparticles for Targeted Lung Delivery.
4664,11512,42193394,10.3390/biomedicines14051069,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNA-Loaded Nanoparticles for Targeted Lung Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA-Loaded Nanoparticles for Targeted Lung Delivery.
4669,11545,42190654,10.1016/j.ajhg.2026.05.002,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Guidance on communication and informed consent with patients and their families for experimental individualized treatments.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Guidance on communication and informed consent with patients and their families for experimental individualized treatments.
4686,11666,42180218,10.3389/fneur.2026.1759410,assay,ASO/siRNA,PubMed abstract sentence 6,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: A high-throughput screening platform to facilitate treatment development in Rett syndrome.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A high-throughput screening platform to facilitate treatment development in Rett syndrome.
4691,11679,42178475,10.1007/978-3-032-20041-9_4,benchmark,ASO/siRNA,PubMed abstract sentence 5,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Modeling Therapeutic Targets: β-Globin Disorders and Beyond.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modeling Therapeutic Targets: β-Globin Disorders and Beyond.
4698,11736,42173110,10.1016/S2468-1253(26)00058-0,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: The small interfering RNA imdusiran as single and multiple doses in healthy, randomised individuals and non-randomised individuals with chronic hepatitis B (AB-729-001): a phase 1a/b trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"The small interfering RNA imdusiran as single and multiple doses in healthy, randomised individuals and non-randomised individuals with chronic hepatitis B (AB-729-001): a phase 1a/b trial."
4704,11774,42170556,10.1016/j.ijpx.2026.100555,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanomedicines for DNA and interference RNA co-delivery: Combined gene therapy for Fabry disease.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanomedicines for DNA and interference RNA co-delivery: Combined gene therapy for Fabry disease.
4706,11778,42170085,10.1039/d6ra01942k,chemistry,ASO/siRNA,PubMed abstract sentence 10,chemical;modification;modified,"chemistry candidate; matched derived terms: chemical, modification, modified; source title: Combinatorial and rational synthesis of complex, base-modified aptamer libraries on microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Combinatorial and rational synthesis of complex, base-modified aptamer libraries on microarrays."
4711,11803,42168358,10.1038/s41418-026-01768-9,chemistry,ASO/siRNA,PubMed abstract sentence 3,modification;2'-o,"chemistry candidate; matched derived terms: modification, 2'-o; source title: LSM7 coordinates scaRNA-mediated snRNA modification to ensure spliceosome fidelity and spermatogonial stem cell differentiation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,LSM7 coordinates scaRNA-mediated snRNA modification to ensure spliceosome fidelity and spermatogonial stem cell differentiation.
4715,11835,42164756,10.34133/research.1288,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: RNA-Targeted Therapeutics for Lipid Metabolic Disorders: From Bench to Bedside.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA-Targeted Therapeutics for Lipid Metabolic Disorders: From Bench to Bedside.
4720,11864,42162902,10.1016/j.metabol.2026.156648,assay,ASO/siRNA,PubMed abstract sentence 4,model;rna-seq,"assay candidate; matched derived terms: model, rna-seq; source title: Macrophage-derived SPP1 promotes subretinal fibrosis by YAP1 phase separation in retinal pigment epithelium.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Macrophage-derived SPP1 promotes subretinal fibrosis by YAP1 phase separation in retinal pigment epithelium.
4725,11903,42158337,10.3389/fddev.2026.1783113,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Oral delivery of biologics: from barrier-limited formulation to active convective transport.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oral delivery of biologics: from barrier-limited formulation to active convective transport.
4736,12004,42148371,10.1109/OJEMB.2026.3678868,assay,ASO/siRNA,PubMed abstract sentence 11,screen;model,"assay candidate; matched derived terms: screen, model; source title: MicroRNA-873 Suppresses Viability and Invasion of Colorectal Cancer Through KRAS/MAPK Signaling and Sensitizes Tumor Spheroids to 5-Fluorouracil in a 3D Microwell Model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MicroRNA-873 Suppresses Viability and Invasion of Colorectal Cancer Through KRAS/MAPK Signaling and Sensitizes Tumor Spheroids to 5-Fluorouracil in a 3D Microwell Model.
4745,12071,42143197,10.1038/s41437-026-00848-3,assay,ASO/siRNA,PubMed abstract sentence 1,screen;model,"assay candidate; matched derived terms: screen, model; source title: Worming out defence strategies: mechanisms of immunity through the lens of genetic screens in C. elegans.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Worming out defence strategies: mechanisms of immunity through the lens of genetic screens in C. elegans.
4754,12122,42137606,10.1016/j.omta.2026.201729,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.
4755,12123,42137606,10.1016/j.omta.2026.201729,assay,ASO/siRNA,PubMed abstract sentence 8,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.
4757,12125,42137606,10.1016/j.omta.2026.201729,benchmark,ASO/siRNA,PubMed abstract sentence 8,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.
4758,12128,42137589,10.1016/j.omta.2026.201727,assay,ASO/siRNA,PubMed abstract sentence 3,assay;trial,"assay candidate; matched derived terms: assay, trial; source title: Development of in vitro potency assays for AAV-based gene silencing therapies targeting FSHD and CMT1A.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of in vitro potency assays for AAV-based gene silencing therapies targeting FSHD and CMT1A.
4769,12171,42132192,10.1161/JAHA.125.043655,assay,ASO/siRNA,PubMed abstract sentence 2,screen;phase;trial,"assay candidate; matched derived terms: screen, phase, trial; source title: Low-Density Lipoprotein Cholesterol Lowering With Inclisiran Plus Usual Care in Recent Acute Coronary Syndrome: VICTORION-INCEPTION, a Randomized, Controlled, Open-Label Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Low-Density Lipoprotein Cholesterol Lowering With Inclisiran Plus Usual Care in Recent Acute Coronary Syndrome: VICTORION-INCEPTION, a Randomized, Controlled, Open-Label Trial."
4778,12218,42127597,10.1016/j.phymed.2026.158266,assay,ASO/siRNA,PubMed abstract sentence 5,assay;screen;model,"assay candidate; matched derived terms: assay, screen, model; source title: Theaflavin protects against ischemic stroke by inhibiting PLA2G4C-driven lipid remodeling and ferroptosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Theaflavin protects against ischemic stroke by inhibiting PLA2G4C-driven lipid remodeling and ferroptosis.
4788,12270,42120691,10.1245/s10434-026-19692-0,toxicity,ASO/siRNA,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineered Exosomes for Delivery of Mir-423-5p to Improve Radiation Sensitivity by Inhibiting MAP7D1 in Esophageal Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineered Exosomes for Delivery of Mir-423-5p to Improve Radiation Sensitivity by Inhibiting MAP7D1 in Esophageal Cancer.
4791,12283,42119877,10.1016/j.nano.2026.102956,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Genetic versus chemical labeling: A quantitative comparison of tracking strategies for extracellular vesicles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Genetic versus chemical labeling: A quantitative comparison of tracking strategies for extracellular vesicles.
4802,12340,42114653,10.1016/j.addr.2026.115893,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: High-dose biologics and bioconjugates delivery: Integrating molecular optimization with device design and routes of administration.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-dose biologics and bioconjugates delivery: Integrating molecular optimization with device design and routes of administration.
4803,12341,42114653,10.1016/j.addr.2026.115893,assay,ASO/siRNA,PubMed abstract sentence 16,screen;model,"assay candidate; matched derived terms: screen, model; source title: High-dose biologics and bioconjugates delivery: Integrating molecular optimization with device design and routes of administration.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-dose biologics and bioconjugates delivery: Integrating molecular optimization with device design and routes of administration.
4811,12371,42112351,10.3389/fimmu.2026.1818316,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aptamers and aptamer-drug conjugates as synthetic immune modulators for cancer immunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamers and aptamer-drug conjugates as synthetic immune modulators for cancer immunotherapy.
4815,12391,42109006,10.1080/1061186X.2026.2638330,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: RNA therapeutics and their delivery methods: a paradigm for haemophilia management.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA therapeutics and their delivery methods: a paradigm for haemophilia management.
4817,12397,42108271,10.1038/s41591-026-04408-4,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: The microRNA inhibitor CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction: a randomized phase 2 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The microRNA inhibitor CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction: a randomized phase 2 trial.
4819,12407,42107506,10.1016/j.critrevonc.2026.105367,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Advances in nucleic acid delivery using nanocarriers for gene therapy in cancer: A narrative review.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in nucleic acid delivery using nanocarriers for gene therapy in cancer: A narrative review.
4823,12439,42104840,10.1161/CIRCHEARTFAILURE.126.014205,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Rationale and Design of CARDIO-TTRansform, a Phase 3 Trial of Eplontersen in Transthyretin Amyloid Cardiomyopathy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Rationale and Design of CARDIO-TTRansform, a Phase 3 Trial of Eplontersen in Transthyretin Amyloid Cardiomyopathy."
4824,12442,42104436,10.1186/s12951-026-04502-2,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Biomimetic hybrid nanoparticles for dual regulation of macrophage pyroptosis and metabolism in rheumatoid arthritis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Biomimetic hybrid nanoparticles for dual regulation of macrophage pyroptosis and metabolism in rheumatoid arthritis.
4833,12527,42093739,10.1016/j.mtbio.2026.103116,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanocarriers engineering for efficient NSUN2 silencing and immune responsive therapy in metastatic colorectal cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanocarriers engineering for efficient NSUN2 silencing and immune responsive therapy in metastatic colorectal cancer.
4842,12594,42087341,10.1002/ps.70888,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticle-enhanced multi-target RNAi in Myzus persicae: Molecular mechanisms, cross-kingdom sRNA transfer, and efficacy for sustainable pest management.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Nanoparticle-enhanced multi-target RNAi in Myzus persicae: Molecular mechanisms, cross-kingdom sRNA transfer, and efficacy for sustainable pest management."
4847,12631,42084709,10.1007/s11033-026-11888-7,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Multi-modal therapeutic approaches to inflammatory bowel disease: plant-derived compounds, nanoparticle drug delivery systems, and gene-based interventions.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Multi-modal therapeutic approaches to inflammatory bowel disease: plant-derived compounds, nanoparticle drug delivery systems, and gene-based interventions."
4853,12661,42079501,10.1016/j.mtbio.2026.103145,assay,ASO/siRNA,PubMed abstract sentence 5,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: A biomimetic nanoplatform enables shTHY1-mediated immunomodulation and cartilage remodeling for osteoarthritis therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A biomimetic nanoplatform enables shTHY1-mediated immunomodulation and cartilage remodeling for osteoarthritis therapy.
4858,12690,42076124,10.3390/pharmaceutics18040472,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Thioester-Containing Ionizable Lipids with Enhanced Endosomal Escape and Biodegradability for mRNA and tRNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Thioester-Containing Ionizable Lipids with Enhanced Endosomal Escape and Biodegradability for mRNA and tRNA Delivery.
4860,12694,42076121,10.3390/pharmaceutics18040470,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Locoregional Delivery of miRNAs for Glioblastoma Treatment: A Systematic Review of Advances in Delivery Systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Locoregional Delivery of miRNAs for Glioblastoma Treatment: A Systematic Review of Advances in Delivery Systems.
4873,12765,42069271,10.1016/j.ijpharm.2026.126918,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Covalent functionalization of polymeric nanoparticles prepared from nano-emulsion templates for gene silencing and antioxidant delivery at neuronal level.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Covalent functionalization of polymeric nanoparticles prepared from nano-emulsion templates for gene silencing and antioxidant delivery at neuronal level.
4884,12826,42064362,10.3389/fgene.2026.1813517,chemistry,ASO/siRNA,PubMed abstract sentence 5,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Brave new RNA world(s): from prebiotic chemistry to gene regulation and RNA technology.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Brave new RNA world(s): from prebiotic chemistry to gene regulation and RNA technology.
4888,12850,42062705,10.1007/s13346-026-02127-4,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Finding the sweet spot between complexation and cytosolic release with different molecular weight branched polyethyleneimine polymers for mRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Finding the sweet spot between complexation and cytosolic release with different molecular weight branched polyethyleneimine polymers for mRNA delivery.
4896,12884,42060212,10.1007/s12672-026-05086-x,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: A patient-derived organoid model identifies TP53-dependent gemcitabine sensitivity in spinal chordoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A patient-derived organoid model identifies TP53-dependent gemcitabine sensitivity in spinal chordoma.
4898,12890,42059549,10.1002/ana.78233,assay,ASO/siRNA,PubMed abstract sentence 5,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: The IL-1β-STING Signaling Axis Drives Neuromyelitis Optica Pathogenesis in a Murine Model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The IL-1β-STING Signaling Axis Drives Neuromyelitis Optica Pathogenesis in a Murine Model.
4909,12963,42051516,10.3389/fimmu.2026.1776008,assay,ASO/siRNA,PubMed abstract sentence 18,screen;model;experiment,"assay candidate; matched derived terms: screen, model, experiment; source title: NR2F2 in cancer-associated fibroblasts drives immune microenvironment remodeling and promotes lung adenocarcinoma progression.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,NR2F2 in cancer-associated fibroblasts drives immune microenvironment remodeling and promotes lung adenocarcinoma progression.
4915,12987,42050003,10.1038/s41598-026-50000-8,assay,ASO/siRNA,PubMed abstract sentence 6,assay;model,"assay candidate; matched derived terms: assay, model; source title: Plant extract mixture shows anti-inflammatory and barrier-strengthening effects and activates aryl hydrocarbon receptor in a 2D psoriasis model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Plant extract mixture shows anti-inflammatory and barrier-strengthening effects and activates aryl hydrocarbon receptor in a 2D psoriasis model.
4925,13035,42046739,10.2147/IJN.S586165,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CXCR4-Targeted Nanotherapeutics: A Promising Approach for Liver Fibrosis and Hepatocellular Carcinoma Management.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CXCR4-Targeted Nanotherapeutics: A Promising Approach for Liver Fibrosis and Hepatocellular Carcinoma Management.
4937,13115,42037751,10.1016/j.jddst.2025.107933,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted delivery of RNA using synthetic bacterial spores.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted delivery of RNA using synthetic bacterial spores.
4940,13126,42036946,10.1016/j.xplc.2026.101870,assay,ASO/siRNA,PubMed abstract sentence 2,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: A multiplex hextuple luciferase assay for advancing cellular signaling analysis in plant cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A multiplex hextuple luciferase assay for advancing cellular signaling analysis in plant cells.
4955,13227,42025248,10.1111/bcpt.70232,assay,ASO,PubMed abstract sentence 1,screen;experiment,"assay candidate; matched derived terms: screen, experiment; source title: Curcumin Alleviates Myocardial Ischaemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis via the Nrf2/HO-1 Pathway: An Integrated Network Pharmacology and Experimental Study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Curcumin Alleviates Myocardial Ischaemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis via the Nrf2/HO-1 Pathway: An Integrated Network Pharmacology and Experimental Study.
4958,13268,42018247,10.1186/s11671-026-04577-8,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A deep dive into ferritin nanoparticle advancements: experimental and computational perspectives.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A deep dive into ferritin nanoparticle advancements: experimental and computational perspectives.
4966,13312,42012511,10.1042/BSR20260143,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: A systematic review and meta-analysis of shRNA-IL-6-engineered CAR-T cells for B-cell acute lymphoblastic leukemia: a stepping stone toward risk-free immunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A systematic review and meta-analysis of shRNA-IL-6-engineered CAR-T cells for B-cell acute lymphoblastic leukemia: a stepping stone toward risk-free immunotherapy.
4971,13329,42011198,10.1016/j.bioactmat.2026.04.012,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Robust loading and delivery of functional small RNAs via protein N-myristoylation-induced small extracellular vesicles.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Robust loading and delivery of functional small RNAs via protein N-myristoylation-induced small extracellular vesicles.
4975,13345,42010388,10.1002/edm2.70220,toxicity,ASO/siRNA,PubMed abstract sentence 8,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Olezarsen in Hypertriglyceridemia With High Cardiac Risk: A GRADE-Assessed Meta-Analysis of Randomized Trials With Trial Sequential Evidence.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Olezarsen in Hypertriglyceridemia With High Cardiac Risk: A GRADE-Assessed Meta-Analysis of Randomized Trials With Trial Sequential Evidence.
4979,13363,42007960,10.1002/smll.202512276,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Smart Nanodelivery for Eye-Brain Disorders: Synergistic CCL2 Neutralization and MMP9 Silencing Reverse Anxiety in High Myopia.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Smart Nanodelivery for Eye-Brain Disorders: Synergistic CCL2 Neutralization and MMP9 Silencing Reverse Anxiety in High Myopia.
4982,13388,42004220,10.1016/j.gendis.2025.101978,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Blockade of co-inhibitory receptor immune checkpoint protein TIM3/CD366 augments the anti-cancer activity of CAR-T therapy in solid tumors: An ovarian cancer example.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Blockade of co-inhibitory receptor immune checkpoint protein TIM3/CD366 augments the anti-cancer activity of CAR-T therapy in solid tumors: An ovarian cancer example.
4983,13403,42003054,10.1002/jcph.70190,assay,ASO/siRNA,PubMed abstract sentence 3,model;phase,"assay candidate; matched derived terms: model, phase; source title: Population Pharmacodynamic Modeling of Plozasiran for Treatment of Familial Chylomicronemia Syndrome.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Population Pharmacodynamic Modeling of Plozasiran for Treatment of Familial Chylomicronemia Syndrome.
4985,13407,42002994,10.2174/0113862073477780260415051730,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: USP35 Acts as a Dual Stabilizer of CDCA8 and PD-L1 to Coordinate the Progression and Immune Evasion in Non-Small Cell Lung Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,USP35 Acts as a Dual Stabilizer of CDCA8 and PD-L1 to Coordinate the Progression and Immune Evasion in Non-Small Cell Lung Cancer.
4987,13411,42002970,10.1002/ps.70839,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Efficient control of Tribulium castaneum using zeolitic imidazolate framework-8 nanocarrier-mediated delivery of dsRNA targeting Paramyosin.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficient control of Tribulium castaneum using zeolitic imidazolate framework-8 nanocarrier-mediated delivery of dsRNA targeting Paramyosin.
4995,13455,41999081,10.1002/glia.70159,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Targeted Inhibition of MEGF10-Mediated Astrogliosis Reduces Glial Scar Formation and Promotes Neurofunction Recovery in Mice After Stroke.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted Inhibition of MEGF10-Mediated Astrogliosis Reduces Glial Scar Formation and Promotes Neurofunction Recovery in Mice After Stroke.
5001,13485,41997330,10.1016/j.ijbiomac.2026.152028,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: pH-responsive HACCs co-delivery of dsRNA and cyenopyrafen synergistically controls Tetranychus urticae and Tetranychus truncatus.",B,high_candidate,curator_rejected,reject,derived_annotations_only,pH-responsive HACCs co-delivery of dsRNA and cyenopyrafen synergistically controls Tetranychus urticae and Tetranychus truncatus.
5005,13505,41995904,10.1007/s00705-026-06627-z,assay,ASO/siRNA,PubMed abstract sentence 5,assay;model,"assay candidate; matched derived terms: assay, model; source title: A novel TaqMan-based RT-qPCR assay for the detection of PEDV and discrimination of the G2c subtype.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A novel TaqMan-based RT-qPCR assay for the detection of PEDV and discrimination of the G2c subtype.
5011,13547,41991735,10.1038/s41598-026-48584-2,delivery,ASO/siRNA,PubMed abstract sentence 13,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A CXCR4 targeting peptide delivered by silica nanoparticles eliminates migrating cancer stem cells in pancreatic ductal adenocarcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A CXCR4 targeting peptide delivered by silica nanoparticles eliminates migrating cancer stem cells in pancreatic ductal adenocarcinoma.
5014,13558,41990465,10.1016/j.biopha.2026.119316,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Ovarian radiation injury and protection: Mechanisms, delivery-enabled interventions, and future directions.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Ovarian radiation injury and protection: Mechanisms, delivery-enabled interventions, and future directions."
5018,13590,41985508,10.1111/cpr.70203,assay,ASO/siRNA,PubMed abstract sentence 7,assay;rna-seq,"assay candidate; matched derived terms: assay, rna-seq; source title: Single-Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Single-Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis.
5031,13633,41981211,10.1038/s41380-026-03603-6,assay,ASO/siRNA,PubMed abstract sentence 7,model;trial,"assay candidate; matched derived terms: model, trial; source title: Clinical innovations and future directions of nanoparticles in the treatment of psychiatric and neurological disorders.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clinical innovations and future directions of nanoparticles in the treatment of psychiatric and neurological disorders.
5035,13661,41978590,10.7759/cureus.105181,assay,ASO/siRNA,PubMed abstract sentence 8,model;trial,"assay candidate; matched derived terms: model, trial; source title: PURA-Related Neurodevelopmental Disorder: A Comprehensive Clinical Review of Genetics, Phenotype, and Emerging Therapeutic Strategies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"PURA-Related Neurodevelopmental Disorder: A Comprehensive Clinical Review of Genetics, Phenotype, and Emerging Therapeutic Strategies."
5036,13668,41977511,10.3390/ijms27073336,assay,ASO/siRNA,PubMed abstract sentence 9,model;phase,"assay candidate; matched derived terms: model, phase; source title: Factor XII in Thrombosis and Thromboinflammation: From Molecular Biology to Clinical Translation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Factor XII in Thrombosis and Thromboinflammation: From Molecular Biology to Clinical Translation.
5038,13674,41977439,10.3390/ijms27073260,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Targeting Non-Coding RNAs as a Potential Therapeutic and Delivery Strategy Against Neurodegenerative Diseases.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting Non-Coding RNAs as a Potential Therapeutic and Delivery Strategy Against Neurodegenerative Diseases.
5040,13678,41977132,10.3390/ijms27072942,assay,ASO/siRNA,PubMed abstract sentence 5,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Microarray-Based Genomic Profiling in Low-Dose Radiation Research: Evidence, Limitations, and Translational Perspectives.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Microarray-Based Genomic Profiling in Low-Dose Radiation Research: Evidence, Limitations, and Translational Perspectives."
5046,13728,41967926,10.1080/0886022X.2026.2641847,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Bergamottin pretreatment attenuates cisplatin-induced acute kidney injury in mice by inhibiting BACE-1-mediated ferroptosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bergamottin pretreatment attenuates cisplatin-induced acute kidney injury in mice by inhibiting BACE-1-mediated ferroptosis.
5053,13761,41965227,10.1016/j.ijgc.2026.104659,assay,ASO/siRNA,PubMed abstract sentence 5,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Unlocking the potential of serum exosomal PIWI-interacting RNAs as diagnostic biomarker for endometrial cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unlocking the potential of serum exosomal PIWI-interacting RNAs as diagnostic biomarker for endometrial cancer.
5066,13824,41960903,10.1158/2767-9764.CRC-26-0175,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Intratumoral Virus-Like Particles Containing a TLR9 Agonist Combined with Systemic αPD-1 Activate Tumor-Specific CD8+ T Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Intratumoral Virus-Like Particles Containing a TLR9 Agonist Combined with Systemic αPD-1 Activate Tumor-Specific CD8+ T Cells.
5067,13827,41959502,10.64898/2026.03.06.710116,assay,ASO/siRNA,PubMed abstract sentence 4,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects.
5068,13832,41959295,10.64898/2026.04.02.716096,assay,ASO/siRNA,PubMed abstract sentence 11,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Patient-derived organoid xenografts reveal the multifaceted role of the lncRNA MALAT1 in breast cancer progression.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Patient-derived organoid xenografts reveal the multifaceted role of the lncRNA MALAT1 in breast cancer progression.
5072,13850,41957177,10.1007/s12094-026-04348-y,assay,ASO/siRNA,PubMed abstract sentence 4,screen;preclinical,"assay candidate; matched derived terms: screen, preclinical; source title: Targeted and molecular therapies in Ewing sarcoma: a comprehensive review of preclinical and clinical advances.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted and molecular therapies in Ewing sarcoma: a comprehensive review of preclinical and clinical advances.
5086,13906,41951573,10.1038/s41467-026-71362-7,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial.
5091,13941,41946917,10.1038/s41591-026-04307-8,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Zodasiran for cholesterol and triglyceride lowering in patients with hyperlipidemia: final report of phase 1 basket trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Zodasiran for cholesterol and triglyceride lowering in patients with hyperlipidemia: final report of phase 1 basket trial.
5102,13996,41940074,10.1016/j.omtn.2026.102870,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Extracellular vesicle-based delivery systems for nucleic acid therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Extracellular vesicle-based delivery systems for nucleic acid therapeutics.
5104,14000,41939723,10.3389/fddev.2026.1776167,delivery,ASO/siRNA,PubMed abstract sentence 12,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Oral delivery of peptides and proteins: pharmacokinetic boundaries, negative selection, and route triage.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Oral delivery of peptides and proteins: pharmacokinetic boundaries, negative selection, and route triage."
5105,14001,41939723,10.3389/fddev.2026.1776167,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Oral delivery of peptides and proteins: pharmacokinetic boundaries, negative selection, and route triage.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Oral delivery of peptides and proteins: pharmacokinetic boundaries, negative selection, and route triage."
5116,14052,41933803,10.1016/j.jconrel.2026.114893,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Biomaterials-guided nanomedicine for familial adenomatous polyposis: lipid nanopartiscle RNA therapeutics with translational relevance.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Biomaterials-guided nanomedicine for familial adenomatous polyposis: lipid nanopartiscle RNA therapeutics with translational relevance.
5119,14081,41931997,10.1016/j.phymed.2026.158097,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Engineered Liposomal Quercetin Attenuates Myocardial Ischemia/Reperfusion Injury via Targeted HMGB1-NF-κB Suppression.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered Liposomal Quercetin Attenuates Myocardial Ischemia/Reperfusion Injury via Targeted HMGB1-NF-κB Suppression.
5121,14125,41924775,10.1016/j.bbrc.2026.153638,assay,ASO/siRNA,PubMed abstract sentence 10,preclinical;model;trial,"assay candidate; matched derived terms: preclinical, model, trial; source title: SNRPD3 promotes endometrial cancer progression via regulating SREBF1 intron retention.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,SNRPD3 promotes endometrial cancer progression via regulating SREBF1 intron retention.
5123,14131,41924453,10.2147/IJN.S588558,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Peptide-Based Nanocarriers for Targeted Drug Delivery: Recent Advances, Strategies, and Therapeutic Frontiers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Peptide-Based Nanocarriers for Targeted Drug Delivery: Recent Advances, Strategies, and Therapeutic Frontiers."
5125,14137,41924248,10.2147/COPD.S580964,benchmark,ASO/siRNA,PubMed abstract sentence 4,model;dataset,"benchmark candidate; matched derived terms: model, dataset; source title: LAMC2 Drives Airway Remodeling in COPD via EMT Regulation Through the AKT Pathway.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,LAMC2 Drives Airway Remodeling in COPD via EMT Regulation Through the AKT Pathway.
5135,14207,41914859,10.1021/acschembio.6c00029,delivery,ASO/siRNA,PubMed abstract sentence 4,galnac;uptake,"delivery candidate; matched derived terms: galnac, uptake; source title: Hepatocyte-Targeted Cyclic Peptide LYTACs for PCSK9 Degradation and LDL Cholesterol Metabolic Regulation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hepatocyte-Targeted Cyclic Peptide LYTACs for PCSK9 Degradation and LDL Cholesterol Metabolic Regulation.
5136,14210,41914483,10.1039/d5nr05222j,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Pneumatically controlled microfluidic synthesis of polymeric nanoparticles for mRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pneumatically controlled microfluidic synthesis of polymeric nanoparticles for mRNA delivery.
5137,14211,41914483,10.1039/d5nr05222j,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pneumatically controlled microfluidic synthesis of polymeric nanoparticles for mRNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pneumatically controlled microfluidic synthesis of polymeric nanoparticles for mRNA delivery.
5141,14223,41913562,10.1111/ene.70580,assay,ASO/siRNA,PubMed abstract sentence 1,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Effect of Eplontersen in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy Across Genetic Variants: An Exploratory Analysis From the NEURO-TTRansform Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of Eplontersen in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy Across Genetic Variants: An Exploratory Analysis From the NEURO-TTRansform Trial.
5142,14226,41913229,10.1186/s12951-026-04347-9,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;conjugate,"chemistry candidate; matched derived terms: chemical, conjugate; source title: pH-responsive virus-drug conjugates for targeted PD-L1 silencing and enhanced cancer immunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,pH-responsive virus-drug conjugates for targeted PD-L1 silencing and enhanced cancer immunotherapy.
5145,14241,41911552,10.1097/HEP.0000000000001757,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNF128 aggravates metabolic dysfunction-associated steatotic liver disease progression via stabilization of SCD1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNF128 aggravates metabolic dysfunction-associated steatotic liver disease progression via stabilization of SCD1.
5149,14265,41910152,10.1080/03639045.2026.2624601,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Stimuli-responsive mesoporous silica nanoparticles for brain tumor theranostics and drug targeting.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Stimuli-responsive mesoporous silica nanoparticles for brain tumor theranostics and drug targeting.
5158,14322,41903689,10.1016/j.nano.2026.102935,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles in oncological therapeutics: Mechanisms of targeted delivery and encapsulation strategies for chemotherapeutics, gene modulators, and phytochemicals.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles in oncological therapeutics: Mechanisms of targeted delivery and encapsulation strategies for chemotherapeutics, gene modulators, and phytochemicals."
5163,14351,41902111,10.3390/s26061937,chemistry,ASO/siRNA,PubMed abstract sentence 2,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: A Target-Displaced Aptamer-cDNA Duplex Strategy on ERGO for Ultrasensitive Turn-On Electrochemical Detection of Ochratoxin A.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Target-Displaced Aptamer-cDNA Duplex Strategy on ERGO for Ultrasensitive Turn-On Electrochemical Detection of Ochratoxin A.
5167,14391,41898615,10.3390/ijms27062755,assay,ASO/siRNA,PubMed abstract sentence 10,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: RNA Therapeutics for Duchenne Muscular Dystrophy: Exon Skipping, RNA Editing, and Translational Insights from Genome-Edited Microminipig Models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"RNA Therapeutics for Duchenne Muscular Dystrophy: Exon Skipping, RNA Editing, and Translational Insights from Genome-Edited Microminipig Models."
5168,14392,41898615,10.3390/ijms27062755,benchmark,ASO/siRNA,PubMed abstract sentence 9,model;challenge,"benchmark candidate; matched derived terms: model, challenge; source title: RNA Therapeutics for Duchenne Muscular Dystrophy: Exon Skipping, RNA Editing, and Translational Insights from Genome-Edited Microminipig Models.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"RNA Therapeutics for Duchenne Muscular Dystrophy: Exon Skipping, RNA Editing, and Translational Insights from Genome-Edited Microminipig Models."
5172,14426,41896932,10.1186/s12951-026-04311-7,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Overcoming lysosomal barrier via V-ATPase: an exosome-based co-delivery platform for combined chemo/RNAi therapy against breast cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Overcoming lysosomal barrier via V-ATPase: an exosome-based co-delivery platform for combined chemo/RNAi therapy against breast cancer.
5173,14427,41896932,10.1186/s12951-026-04311-7,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Overcoming lysosomal barrier via V-ATPase: an exosome-based co-delivery platform for combined chemo/RNAi therapy against breast cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Overcoming lysosomal barrier via V-ATPase: an exosome-based co-delivery platform for combined chemo/RNAi therapy against breast cancer.
5181,14495,41888083,10.1021/acsnano.5c19462,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: dsRNA-Loaded Silica Nanoparticles for the Management of Potato Virus Y in Potato Plants.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,dsRNA-Loaded Silica Nanoparticles for the Management of Potato Virus Y in Potato Plants.
5188,14526,41884417,10.2147/BCTT.S572244,assay,ASO/siRNA,PubMed abstract sentence 8,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: Identification of Potential Therapeutic Targets for Xihuang Pill in Breast Cancer: A Mendelian Randomization and Experimental Study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of Potential Therapeutic Targets for Xihuang Pill in Breast Cancer: A Mendelian Randomization and Experimental Study.
5191,14543,41882995,10.1021/acs.analchem.5c07608,chemistry,ASO/siRNA,PubMed abstract sentence 3,modification;conjugate,"chemistry candidate; matched derived terms: modification, conjugate; source title: A Portable Surface-Free Electrochemical Aptamer-Based Biosensor for Multiplex Detection of Arboviruses.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Portable Surface-Free Electrochemical Aptamer-Based Biosensor for Multiplex Detection of Arboviruses.
5193,14569,41881029,10.1021/acsami.5c24581,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Programmable Lipid Functionalization of Nucleic Acid Nanoparticles Modulates Liver Cell-Type Targeting.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Programmable Lipid Functionalization of Nucleic Acid Nanoparticles Modulates Liver Cell-Type Targeting.
5198,14584,41879908,10.1007/s12325-026-03541-3,assay,ASO/siRNA,PubMed abstract sentence 6,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Factor XI Inhibitors in Atrial Fibrillation: Insights and Implications from Recent Trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Factor XI Inhibitors in Atrial Fibrillation: Insights and Implications from Recent Trials.
5203,14599,41877526,10.1021/acs.molpharmaceut.5c01966,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Anti-EGFR Aptamer-Conjugated Erythrocyte Membrane-Derived Nanoparticles for Targeted Doxorubicin Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Anti-EGFR Aptamer-Conjugated Erythrocyte Membrane-Derived Nanoparticles for Targeted Doxorubicin Delivery.
5209,14615,41876668,10.1038/s41598-026-42810-7,assay,ASO/siRNA,PubMed abstract sentence 4,screen;model,"assay candidate; matched derived terms: screen, model; source title: Identification of cellular ion channels that facilitate Hazara nairovirus infection enables selection of clinically approved compounds with anti-nairoviral properties.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of cellular ion channels that facilitate Hazara nairovirus infection enables selection of clinically approved compounds with anti-nairoviral properties.
5216,14690,41869412,10.2147/IJN.S562959,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: How Effective are Nanotechnology-Based Therapeutics to Treat Autoimmune Diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,How Effective are Nanotechnology-Based Therapeutics to Treat Autoimmune Diseases.
5217,14693,41869410,10.2147/IJN.S566642,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, uptake; source title: Targeted Delivery of Nucleic Acid Therapeutics: Emerging Carriers and Applications in Common Metabolic and Inflammatory Diseases.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted Delivery of Nucleic Acid Therapeutics: Emerging Carriers and Applications in Common Metabolic and Inflammatory Diseases.
5225,14753,41862624,10.1038/s41598-026-44959-7,assay,ASO/siRNA,PubMed abstract sentence 6,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Macroscopic polarimetric discrimination and quantification of antiangiogenic effect of AGRO aptamer and GK1 peptide in a preclinical melanoma model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Macroscopic polarimetric discrimination and quantification of antiangiogenic effect of AGRO aptamer and GK1 peptide in a preclinical melanoma model.
5231,14783,41860232,10.1080/15257770.2026.2645371,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: A chemical labeling method for selective conjugation to DNA 3'-phosphoglycolate termini.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A chemical labeling method for selective conjugation to DNA 3'-phosphoglycolate termini.
5247,14863,41852738,10.1016/j.isci.2026.114971,assay,ASO/siRNA,PubMed abstract sentence 3,screen;model,"assay candidate; matched derived terms: screen, model; source title: Hbs and Rst adhesion molecules provide a regional code that regulates cell elimination during epithelial remodeling.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hbs and Rst adhesion molecules provide a regional code that regulates cell elimination during epithelial remodeling.
5260,14926,41848347,10.1042/BCJ20253458,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Modulating backbone flexibility in hydroxamate siderophores for improved iron chelation and peptide nucleic acid delivery into bacteria.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modulating backbone flexibility in hydroxamate siderophores for improved iron chelation and peptide nucleic acid delivery into bacteria.
5265,14945,41846049,10.1002/ptr.70309,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Astragalus Polysaccharide Alleviated Septic Associated Acute Kidney Injury Through Dual Mechanisms of RIPK1-Dependent Necroptosis and Autophagy in Macrophage.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Astragalus Polysaccharide Alleviated Septic Associated Acute Kidney Injury Through Dual Mechanisms of RIPK1-Dependent Necroptosis and Autophagy in Macrophage.
5268,14968,41843791,10.14744/AnatolJCardiol.2026.6255,assay,ASO/siRNA,PubMed abstract sentence 6,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Managing Progressive Atherosclerotic Cardiovascular Disease in a Patient with Elevated Lipoprotein(a).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Managing Progressive Atherosclerotic Cardiovascular Disease in a Patient with Elevated Lipoprotein(a).
5271,14991,41840642,10.1186/s12951-026-04256-x,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: tLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress.",B,high_candidate,curator_rejected,reject,derived_annotations_only,tLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress.
5275,15007,41839309,10.1016/j.ejps.2026.107503,assay,ASO/siRNA,PubMed abstract sentence 12,preclinical;phase;trial,"assay candidate; matched derived terms: preclinical, phase, trial; source title: Preclinical validation of tetrahydroquinoline derivatives as EGFR inhibitor inducing glioblastoma cell death.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical validation of tetrahydroquinoline derivatives as EGFR inhibitor inducing glioblastoma cell death.
5276,15010,41838952,10.1021/acs.molpharmaceut.5c01098,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Small Activating RNAs: Delivery and Therapeutic Applications in Disease Treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Small Activating RNAs: Delivery and Therapeutic Applications in Disease Treatment.
5286,15060,41836375,10.3389/fimmu.2026.1791263,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Precise delivery and controlled release: strategies and advances in TLR7/8 agonist prodrugs for cancer immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Precise delivery and controlled release: strategies and advances in TLR7/8 agonist prodrugs for cancer immunotherapy.
5287,15061,41836375,10.3389/fimmu.2026.1791263,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Precise delivery and controlled release: strategies and advances in TLR7/8 agonist prodrugs for cancer immunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Precise delivery and controlled release: strategies and advances in TLR7/8 agonist prodrugs for cancer immunotherapy.
5295,15111,41831873,10.1016/j.pestbp.2026.107005,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanocarrier-delivered dsRNA targeting cuticular protein CPAP3-2 enhances Etoxazole efficacy in tetranychid mites.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanocarrier-delivered dsRNA targeting cuticular protein CPAP3-2 enhances Etoxazole efficacy in tetranychid mites.
5299,15121,41831794,10.1016/j.ijrobp.2026.03.005,benchmark,ASO/siRNA,PubMed abstract sentence 4,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: A New Predictive Model for Radiation Necrosis Risk Based on PTV-Enriched Blood Inflammatory Biomarkers in Patients With Brain Metastases Treated With Stereotactic Radiosurgery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A New Predictive Model for Radiation Necrosis Risk Based on PTV-Enriched Blood Inflammatory Biomarkers in Patients With Brain Metastases Treated With Stereotactic Radiosurgery.
5305,15161,41827106,10.3390/jcm15051688,toxicity,ASO/siRNA,PubMed abstract sentence 2,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Impact of Lipoprotein(a) on Residual Cardiovascular Risk After an Acute Coronary Syndrome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Impact of Lipoprotein(a) on Residual Cardiovascular Risk After an Acute Coronary Syndrome.
5309,15171,41826614,10.1038/s41598-026-43719-x,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exosome-mediated delivery of miRNA-1290 inhibitor enhances JNK-dependent tissue-resident memory T cell immunity in prostate cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exosome-mediated delivery of miRNA-1290 inhibitor enhances JNK-dependent tissue-resident memory T cell immunity in prostate cancer.
5313,15183,41824501,10.1073/pnas.2534439123,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: SonoPIN enables precise, noninvasive, and efficient intracellular delivery of PROTACs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"SonoPIN enables precise, noninvasive, and efficient intracellular delivery of PROTACs."
5315,15195,41822318,10.14740/wjon2663,assay,ASO/siRNA,PubMed abstract sentence 12,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Analysis of Prognosis and Immune Microenvironment of Protein Kinase C Substrate 80K-H in Diabetic Lung Cancer Patients.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Analysis of Prognosis and Immune Microenvironment of Protein Kinase C Substrate 80K-H in Diabetic Lung Cancer Patients.
5319,15205,41821312,10.1016/j.ymthe.2026.03.013,assay,ASO/siRNA,PubMed abstract sentence 6,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Delpacibart etedesiran improves the molecular pathology of myotonic dystrophy type 1 in the phase 1/2 MARINA study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delpacibart etedesiran improves the molecular pathology of myotonic dystrophy type 1 in the phase 1/2 MARINA study.
5320,15216,41819327,10.1016/j.ijbiomac.2026.151362,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: AS1411-aptamer-functionalized DNA tetrahedron for targeted delivery of vorinostat to suppress gastric cancer progression via ferroptosis induction and epithelial-mesenchymal transition inhibition.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,AS1411-aptamer-functionalized DNA tetrahedron for targeted delivery of vorinostat to suppress gastric cancer progression via ferroptosis induction and epithelial-mesenchymal transition inhibition.
5326,15252,41814308,10.1186/s12964-026-02803-5,assay,ASO/siRNA,PubMed abstract sentence 6,model;phase,"assay candidate; matched derived terms: model, phase; source title: Precise metabolomics identifies glycolysis-related pyruvate kinase M activity as regulator of the S-phase-specific radiation response in triple-negative breast cancer cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Precise metabolomics identifies glycolysis-related pyruvate kinase M activity as regulator of the S-phase-specific radiation response in triple-negative breast cancer cells.
5327,15263,41812535,10.1016/j.bmc.2026.118614,chemistry,siRNA,PubMed abstract sentence 2,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Enhancing RNAi activity through 4'-O-hexadecyl-2'-deoxythymidine modification in the passenger strand.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhancing RNAi activity through 4'-O-hexadecyl-2'-deoxythymidine modification in the passenger strand.
5329,15277,41808888,10.4252/wjsc.v18.i2.112940,assay,ASO/siRNA,PubMed abstract sentence 11,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: GATA2 deficiency exacerbates chronic liver injury via disrupting hepatocyte death-regeneration balance: Clinical, histopathological, and molecular evidence.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"GATA2 deficiency exacerbates chronic liver injury via disrupting hepatocyte death-regeneration balance: Clinical, histopathological, and molecular evidence."
5332,15284,41808575,10.1002/smll.202511570,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Vertex-Integrated Tetrahedral DNA Nanoframe Enhances miR-143-3p Delivery for Osteoarthritis Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Vertex-Integrated Tetrahedral DNA Nanoframe Enhances miR-143-3p Delivery for Osteoarthritis Therapy.
5343,15365,41799402,10.1021/acsnanomed.6c00004,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Engineering Optimized EV-Mimetic Carriers for Efficient Tumor-Targeted Delivery of Functional RNA Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineering Optimized EV-Mimetic Carriers for Efficient Tumor-Targeted Delivery of Functional RNA Nanoparticles.
5344,15366,41799402,10.1021/acsnanomed.6c00004,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineering Optimized EV-Mimetic Carriers for Efficient Tumor-Targeted Delivery of Functional RNA Nanoparticles.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineering Optimized EV-Mimetic Carriers for Efficient Tumor-Targeted Delivery of Functional RNA Nanoparticles.
5349,15389,41795804,10.1002/cam4.71712,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: SLC12A8 Drives Immune Evasion and Metastasis in Luminal B Breast Cancer by Inducing CD8(+) T-Cell Exhaustion via the TLR Signaling Pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SLC12A8 Drives Immune Evasion and Metastasis in Luminal B Breast Cancer by Inducing CD8(+) T-Cell Exhaustion via the TLR Signaling Pathway.
5358,15434,41791661,10.1016/j.jtha.2026.02.011,assay,ASO/siRNA,PubMed abstract sentence 5,assay;model;experiment,"assay candidate; matched derived terms: assay, model, experiment; source title: Functional impact of PROC variants on splicing and protein C activity: evidence for clinical reclassification and RNA therapeutic approaches.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Functional impact of PROC variants on splicing and protein C activity: evidence for clinical reclassification and RNA therapeutic approaches.
5359,15437,41790895,10.1126/sciadv.adw0891,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A worm-like nucleic acid nanostructure for gene delivery and endosomal escape via ClC3 ion exchanger.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A worm-like nucleic acid nanostructure for gene delivery and endosomal escape via ClC3 ion exchanger.
5360,15438,41790895,10.1126/sciadv.adw0891,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A worm-like nucleic acid nanostructure for gene delivery and endosomal escape via ClC3 ion exchanger.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A worm-like nucleic acid nanostructure for gene delivery and endosomal escape via ClC3 ion exchanger.
5362,15450,41790360,10.1007/s11882-026-01265-6,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Emerging Therapeutic Strategies in Asthma: Advances in Treatment, Drug Delivery, Drug Adherence, and Disease Management.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Emerging Therapeutic Strategies in Asthma: Advances in Treatment, Drug Delivery, Drug Adherence, and Disease Management."
5366,15470,41787499,10.1186/s12967-026-07876-x,assay,ASO/siRNA,PubMed abstract sentence 3,model;rna-seq,"assay candidate; matched derived terms: model, rna-seq; source title: Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP axis as a therapeutic target in pulmonary fibrosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP axis as a therapeutic target in pulmonary fibrosis.
5373,15511,41783937,10.1039/d5tb02754c,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ionizable mesoporous silica nanoparticle-mediated siAURKB delivery for colorectal cancer therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Ionizable mesoporous silica nanoparticle-mediated siAURKB delivery for colorectal cancer therapy.
5380,15568,41774227,10.1007/s10495-025-02243-5,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: M2pep-modified liposomal nanoparticles delivering siITGB4 induce apoptosis and inhibit NSCLC metastasis via macrophage reprogramming.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,M2pep-modified liposomal nanoparticles delivering siITGB4 induce apoptosis and inhibit NSCLC metastasis via macrophage reprogramming.
5387,15619,41765300,10.1016/j.ijbiomac.2026.151135,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Optimizing T cell responses of targeted peptide antigen delivery by modulating antigen processing through amino acid exchange.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Optimizing T cell responses of targeted peptide antigen delivery by modulating antigen processing through amino acid exchange.
5389,15639,41762583,10.1016/j.bioadv.2026.214785,delivery,ASO/siRNA,PubMed abstract sentence 9,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Aptamer-targeted biomimetic gold nanostar core with mesoporous organosilica layer for NIR-triggered chemo-photothermal therapy and CT imaging of melanoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-targeted biomimetic gold nanostar core with mesoporous organosilica layer for NIR-triggered chemo-photothermal therapy and CT imaging of melanoma.
5394,15666,41759420,10.1016/j.phymed.2026.157997,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ginsenoside Rg2 ameliorates acute cold exposure/rewarming-induced myocardial injury via modulating HMGB1/TLR4/NF-κB and PGC-1α signaling pathways: Role of SIRT1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ginsenoside Rg2 ameliorates acute cold exposure/rewarming-induced myocardial injury via modulating HMGB1/TLR4/NF-κB and PGC-1α signaling pathways: Role of SIRT1.
5396,15676,41757439,10.1080/14728222.2026.2638755,assay,ASO/siRNA,PubMed abstract sentence 6,model;rna-seq,"assay candidate; matched derived terms: model, rna-seq; source title: Novel therapeutic targets for abdominal aortic aneurysm treatment: evidence from recent preclinical research.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel therapeutic targets for abdominal aortic aneurysm treatment: evidence from recent preclinical research.
5404,15722,41750126,10.3390/brainsci16020125,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exosomes as Specific Vehicles for Delivery of Combination Therapies for Inhibiting Autophagy and Inducing Apoptosis in MYCN-Amplified Neuroblastoma Displaying Gut Dysbiosis: Current Challenges and Future Opportunities.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exosomes as Specific Vehicles for Delivery of Combination Therapies for Inhibiting Autophagy and Inducing Apoptosis in MYCN-Amplified Neuroblastoma Displaying Gut Dysbiosis: Current Challenges and Future Opportunities.
5406,15728,41749458,10.1093/cvr/cvag048,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Dysregulated Klotho and FGF23 signalling aggravates vascular remodelling in age-related pulmonary hypertension.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dysregulated Klotho and FGF23 signalling aggravates vascular remodelling in age-related pulmonary hypertension.
5425,15807,41738422,10.1714/4650.46649,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: [Factor XI inhibition in atrial fibrillation: where do we stand?].",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,[Factor XI inhibition in atrial fibrillation: where do we stand?].
5446,15904,41721927,10.1007/s12672-026-04663-4,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exosomal nanocarriers for targeted drug delivery in cancer therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exosomal nanocarriers for targeted drug delivery in cancer therapy.
5451,15933,41716677,10.1016/j.bioactmat.2026.02.009,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Spatiotemporal reprogramming of cardiac lipid metabolism by platelet-engineered RNA therapy epigenetically modulate heart repair and regeneration.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Spatiotemporal reprogramming of cardiac lipid metabolism by platelet-engineered RNA therapy epigenetically modulate heart repair and regeneration.
5452,15934,41716677,10.1016/j.bioactmat.2026.02.009,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Spatiotemporal reprogramming of cardiac lipid metabolism by platelet-engineered RNA therapy epigenetically modulate heart repair and regeneration.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Spatiotemporal reprogramming of cardiac lipid metabolism by platelet-engineered RNA therapy epigenetically modulate heart repair and regeneration.
5456,15950,41714538,10.1007/s11307-026-02087-8,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Template-Directed RIG-I Agonist Assembly for Image-guided Targeted Cancer Immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Template-Directed RIG-I Agonist Assembly for Image-guided Targeted Cancer Immunotherapy.
5465,15985,41709848,10.1039/d5tb02487k,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Effective inhibition of lung metastatic melanoma by pH-responsive lipopeptide/PLGA hybrid nanoparticles silencing PD-L1 with augmented suppression of the AKT/β-catenin pathway.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effective inhibition of lung metastatic melanoma by pH-responsive lipopeptide/PLGA hybrid nanoparticles silencing PD-L1 with augmented suppression of the AKT/β-catenin pathway.
5467,15989,41709264,10.1186/s12951-026-04195-7,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Novel Homo-SELEX for selecting universal aptamer for cross-species kidney injury biomarker KIM-1 in muti-scenario situ imaging.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Novel Homo-SELEX for selecting universal aptamer for cross-species kidney injury biomarker KIM-1 in muti-scenario situ imaging.
5468,15992,41709219,10.1186/s12951-026-04094-x,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Steering spherical nucleic acids over metabolic organs for improved targeted drug delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Steering spherical nucleic acids over metabolic organs for improved targeted drug delivery.
5469,15993,41709219,10.1186/s12951-026-04094-x,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Steering spherical nucleic acids over metabolic organs for improved targeted drug delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Steering spherical nucleic acids over metabolic organs for improved targeted drug delivery.
5483,16053,41700630,10.1002/adma.202517706,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: High-Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting.
5485,16067,41698791,10.1021/acs.accounts.5c00874,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid-Polymer Hybrid Nanoparticles (LPHNPs) for RNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid-Polymer Hybrid Nanoparticles (LPHNPs) for RNA Delivery.
5488,16074,41698609,10.1016/j.jconrel.2026.114729,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Nucleic acid drug delivery in ophthalmology: Emerging trends and future perspectives.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nucleic acid drug delivery in ophthalmology: Emerging trends and future perspectives.
5491,16099,41694334,10.3389/fimmu.2026.1738596,assay,ASO/siRNA,PubMed abstract sentence 4,assay;model;experiment,"assay candidate; matched derived terms: assay, model, experiment; source title: The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer.
5493,16101,41694334,10.3389/fimmu.2026.1738596,benchmark,ASO/siRNA,PubMed abstract sentence 4,database;model;tool,"benchmark candidate; matched derived terms: database, model, tool; source title: The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer.
5500,16130,41688131,10.1080/17435889.2026.2628235,delivery,ASO/siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Roles and applications of peptide nucleic acid-loaded nanoparticles in cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Roles and applications of peptide nucleic acid-loaded nanoparticles in cancer.
5518,16228,41676641,10.64898/2026.02.03.703549,assay,ASO/siRNA,PubMed abstract sentence 9,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Cognate amino acid therapies provide preclinical benefit in 19 C. elegans models of ARS2 deficiency.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cognate amino acid therapies provide preclinical benefit in 19 C. elegans models of ARS2 deficiency.
5520,16232,41675859,10.1097/MS9.0000000000004491,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Nanocarrier-based CircRNA therapeutics in inherited retinal dystrophies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanocarrier-based CircRNA therapeutics in inherited retinal dystrophies.
5524,16256,41673497,10.1038/s43587-025-01031-9,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Exploratory analyses of clinical outcomes from the BIIB080 phase 1b study in mild Alzheimer's disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exploratory analyses of clinical outcomes from the BIIB080 phase 1b study in mild Alzheimer's disease.
5528,16282,41667962,10.1186/s12870-026-08354-8,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Induction of plant resistance to bean common mosaic virus (BCMV) via multiple applications of nanoparticle-conjugated dsRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Induction of plant resistance to bean common mosaic virus (BCMV) via multiple applications of nanoparticle-conjugated dsRNA.
5530,16288,41667381,10.1002/wsbm.70007,benchmark,ASO/siRNA,PubMed abstract sentence 7,model;challenge,"benchmark candidate; matched derived terms: model, challenge; source title: Nager Syndrome Revisited: Integrating In Vivo and In Vitro Models to Decipher SF3B4-Dependent Tissue Coordination.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nager Syndrome Revisited: Integrating In Vivo and In Vitro Models to Decipher SF3B4-Dependent Tissue Coordination.
5534,16310,41663519,10.1038/s42003-026-09650-7,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model;phase,"assay candidate; matched derived terms: preclinical, model, phase; source title: Model selection in preclinical nucleic acid therapeutics research.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Model selection in preclinical nucleic acid therapeutics research.
5537,16319,41662774,10.1088/1361-6528/ae435b,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A hepatic-targeted glycogen-based nano-platform enables efficient CTGF silencing and attenuates liver fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A hepatic-targeted glycogen-based nano-platform enables efficient CTGF silencing and attenuates liver fibrosis.
5540,16324,41661421,10.1007/s10856-026-07012-7,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Smart nanoparticle delivery systems for curcumin: a targeted strategy to enhance anticancer efficacy and bioavailability.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Smart nanoparticle delivery systems for curcumin: a targeted strategy to enhance anticancer efficacy and bioavailability.
5547,16343,41659610,10.64898/2026.01.27.702075,assay,ASO/siRNA,PubMed abstract sentence 14,screen;model,"assay candidate; matched derived terms: screen, model; source title: A Robust Chemical-free Platform for Age-Synchronized Caenorhabditis elegans Populations Maintenance for High-Throughput Screening in Aging Studies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Robust Chemical-free Platform for Age-Synchronized Caenorhabditis elegans Populations Maintenance for High-Throughput Screening in Aging Studies.
5559,16407,41649705,10.1186/s11671-026-04450-8,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticle approaches for hepatitis therapy and clinical translation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticle approaches for hepatitis therapy and clinical translation.
5560,16408,41649705,10.1186/s11671-026-04450-8,assay,ASO/siRNA,PubMed abstract sentence 7,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Nanoparticle approaches for hepatitis therapy and clinical translation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticle approaches for hepatitis therapy and clinical translation.
5561,16417,41648448,10.64898/2026.01.22.701067,delivery,ASO/siRNA,PubMed abstract sentence 9,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Endocytosis of PEGylated polymeric mesoscale nanoparticles is dynamin- and macropinocytosis-dependent.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Endocytosis of PEGylated polymeric mesoscale nanoparticles is dynamin- and macropinocytosis-dependent.
5568,16434,41645864,10.1002/adhm.202600013,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Spatiotemporally Cascade-Releasing Polyester Nanoparticles for Synergistic Photodynamic/Chemo/Gene Therapy of Colorectal Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Spatiotemporally Cascade-Releasing Polyester Nanoparticles for Synergistic Photodynamic/Chemo/Gene Therapy of Colorectal Cancer.
5584,16504,41636743,10.1002/advs.202516446,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis.
5587,16521,41634391,10.1038/s41591-025-04193-6,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: High-dose nusinersen for spinal muscular atrophy: a phase 3 randomized trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-dose nusinersen for spinal muscular atrophy: a phase 3 randomized trial.
5589,16529,41633581,10.19723/j.issn.1671-167X.2026.01.003,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: [Anti-inflammatory effects of cell membrane vesicle-mediated delivery of small interfering RNA targeting tumor necrosis factor-α on dental pulp stem cells].",B,high_candidate,curator_rejected,reject,derived_annotations_only,[Anti-inflammatory effects of cell membrane vesicle-mediated delivery of small interfering RNA targeting tumor necrosis factor-α on dental pulp stem cells].
5594,16580,41628709,10.1016/j.jconrel.2026.114663,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Delivery science: Its increasing importance for the next generation of medicines.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery science: Its increasing importance for the next generation of medicines.
5597,16589,41627316,10.1039/d5ay01680k,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Aptamer-functionalized 3D gold nanodendrite platform for electrochemical detection of circulating tumor cells in breast cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-functionalized 3D gold nanodendrite platform for electrochemical detection of circulating tumor cells in breast cancer.
5598,16592,41626862,10.1039/d5cc06813d,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Liposome-based delivery of DNA aptamers to inhibit erythromycin methyltransferase-mediated antibiotic resistance.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Liposome-based delivery of DNA aptamers to inhibit erythromycin methyltransferase-mediated antibiotic resistance.
5612,16672,41615621,10.1007/s13346-026-02044-6,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The RNA delivery dilemma-lipid versus polymer nanoparticle platforms.
5626,16760,41599761,10.3390/ph19010164,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Aptamer-Based Delivery of Genes and Drugs Across the Blood-Brain Barrier.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-Based Delivery of Genes and Drugs Across the Blood-Brain Barrier.
5638,16806,41596290,10.3390/ijms27020634,delivery,ASO/siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Molecular Mechanisms Underlying Atherosclerosis and Current Advances in Targeted Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Molecular Mechanisms Underlying Atherosclerosis and Current Advances in Targeted Therapeutics.
5639,16815,41595486,10.3390/genes17010066,assay,ASO/siRNA,PubMed abstract sentence 10,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: The Genetic and Epigenetic Architecture of Keratoconus: Emerging Pathways and Clinical Implications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Genetic and Epigenetic Architecture of Keratoconus: Emerging Pathways and Clinical Implications.
5640,16832,41592954,10.1021/acs.analchem.5c06592,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Chitosan-Functionalized Magnetic Graphene Oxide Nanocomposites Enable High-Purity mRNA Enrichment To Avoid False Positives in LC-MS/MS Modification Profiling.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chitosan-Functionalized Magnetic Graphene Oxide Nanocomposites Enable High-Purity mRNA Enrichment To Avoid False Positives in LC-MS/MS Modification Profiling.
5648,16898,41580904,10.1002/adhm.202504723,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted Delivery of Avacopan via Sortase A-Modified Extracellular Vesicles Attenuates Endotoxin-Induced Retinal Inflammation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted Delivery of Avacopan via Sortase A-Modified Extracellular Vesicles Attenuates Endotoxin-Induced Retinal Inflammation.
5649,16903,41580458,10.1038/s41598-026-37047-3,assay,ASO/siRNA,PubMed abstract sentence 10,assay;trial,"assay candidate; matched derived terms: assay, trial; source title: Development and preliminary evaluation of real-time PCR assays for six lactic acid bacteria.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development and preliminary evaluation of real-time PCR assays for six lactic acid bacteria.
5653,16917,41579835,10.1016/j.bioadv.2026.214725,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanotechnology-driven drug delivery systems for breast cancer: A review.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanotechnology-driven drug delivery systems for breast cancer: A review.
5654,16918,41579835,10.1016/j.bioadv.2026.214725,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanotechnology-driven drug delivery systems for breast cancer: A review.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanotechnology-driven drug delivery systems for breast cancer: A review.
5658,16932,41577321,10.1016/j.ejphar.2026.178585,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Triple drug co-delivery within nanosystems for synergistic anti-infective, anti-inflammatory, antinociceptive and neuroregenerative therapeutic effects: a focus on pharmacological and nanotechnological aspects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Triple drug co-delivery within nanosystems for synergistic anti-infective, anti-inflammatory, antinociceptive and neuroregenerative therapeutic effects: a focus on pharmacological and nanotechnological aspects."
5664,16970,41572365,10.1002/advs.202519330,assay,ASO/siRNA,PubMed abstract sentence 3,model;rna-seq,"assay candidate; matched derived terms: model, rna-seq; source title: Identification of a Force-Induced Sox9(+)Acan(+) Transitional Subpopulation Linked to FGF2-FGFR2-ERK Signaling in Orthodontic Bone Remodeling.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of a Force-Induced Sox9(+)Acan(+) Transitional Subpopulation Linked to FGF2-FGFR2-ERK Signaling in Orthodontic Bone Remodeling.
5677,17043,41560841,10.1016/j.mtbio.2025.102693,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Design and in vitro validation of Brome mosaic -virus-like particles for gene delivery and immunomodulation of melanoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Design and in vitro validation of Brome mosaic -virus-like particles for gene delivery and immunomodulation of melanoma.
5681,17055,41560785,10.1016/j.mtbio.2025.102631,assay,ASO/siRNA,PubMed abstract sentence 2,model;rna-seq,"assay candidate; matched derived terms: model, rna-seq; source title: Interferon-stimulated gene 15 small interfering RNA-loaded polarized mesoporous silica nanocarriers remodel the immune microenvironment to ameliorate post-myocardial infarction heart failure.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Interferon-stimulated gene 15 small interfering RNA-loaded polarized mesoporous silica nanocarriers remodel the immune microenvironment to ameliorate post-myocardial infarction heart failure.
5684,17066,41559781,10.1186/s12944-026-02862-0,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Hypertriglyceridemia in chronic kidney disease: pathophysiological mechanisms, cardiovascular risk, and emerging therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Hypertriglyceridemia in chronic kidney disease: pathophysiological mechanisms, cardiovascular risk, and emerging therapeutics."
5696,17118,41552386,10.1016/j.omtn.2025.102810,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: PPMO-based exon skipping therapy improves respiratory function in the mdx mouse model of Duchenne muscular dystrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,PPMO-based exon skipping therapy improves respiratory function in the mdx mouse model of Duchenne muscular dystrophy.
5706,17166,41545357,10.1038/s41467-025-65104-4,assay,ASO/siRNA,PubMed abstract sentence 4,screen;model,"assay candidate; matched derived terms: screen, model; source title: Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy.
5709,17175,41544794,10.1016/j.ijbiomac.2026.150223,delivery,siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: RNAi therapy targeting coronavirus genomes, pulmonary delivery strategies and design principles: A review.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"RNAi therapy targeting coronavirus genomes, pulmonary delivery strategies and design principles: A review."
5713,17197,41540528,10.2174/0115665232425141251028050552,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Targeted TP53 and KRAS Modulation Via AuNP-Mediated RNA Delivery Suppresses Cancer Progression.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted TP53 and KRAS Modulation Via AuNP-Mediated RNA Delivery Suppresses Cancer Progression.
5716,17208,41540052,10.1038/s41540-025-00643-6,assay,ASO/siRNA,PubMed abstract sentence 3,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Modeling the microRNA regulation of TGF-β/SMAD signaling pathways for seizure control in temporal lobe epilepsy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modeling the microRNA regulation of TGF-β/SMAD signaling pathways for seizure control in temporal lobe epilepsy.
5721,17221,41538995,10.1088/1748-605X/ae3933,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Understanding advanced poly (ethylene glycol)-disulphide-poly (lactic-co-glycolic acid) (PEG-SS-PLGA) nanoparticles for cutting-edge innovations, applications in smart drug delivery systems and targeted cancer therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Understanding advanced poly (ethylene glycol)-disulphide-poly (lactic-co-glycolic acid) (PEG-SS-PLGA) nanoparticles for cutting-edge innovations, applications in smart drug delivery systems and targeted cancer therapy."
5727,17241,41534193,10.1016/j.placenta.2026.01.005,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Adeno-associated viral vector-mediated gene delivery and shRNA knockdown in primary human cytotrophoblasts.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Adeno-associated viral vector-mediated gene delivery and shRNA knockdown in primary human cytotrophoblasts.
5745,17387,41506585,10.1016/j.ejps.2026.107428,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Design and evaluation of dual-functional aptamer-peptide conjugates as a platform for targeted cancer therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Design and evaluation of dual-functional aptamer-peptide conjugates as a platform for targeted cancer therapy.
5756,17424,41501129,10.1038/s41598-025-34487-1,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted drug delivery to AML by OFA/iLRP aptamer guided DNA nanostructure.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted drug delivery to AML by OFA/iLRP aptamer guided DNA nanostructure.
5765,17483,41491011,10.1038/s41598-025-34313-8,benchmark,ASO/siRNA,PubMed abstract sentence 10,model;dataset,"benchmark candidate; matched derived terms: model, dataset; source title: ‌PPIA regulates fatty acid and glutamine metabolism in lung adenocarcinoma based on multiomics prognostic model and experiment validation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,‌PPIA regulates fatty acid and glutamine metabolism in lung adenocarcinoma based on multiomics prognostic model and experiment validation.
5779,17553,41478044,10.1016/j.talanta.2025.129322,chemistry,ASO/siRNA,PubMed abstract sentence 8,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Multiplexed 3D-rGO/AuNP electrochemical aptasensor for ultrasensitive detection of urinary PSMA in prostate cancer diagnosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multiplexed 3D-rGO/AuNP electrochemical aptasensor for ultrasensitive detection of urinary PSMA in prostate cancer diagnosis.
5780,17558,41476373,10.1021/acs.molpharmaceut.5c00774,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: mRNA-Based Therapeutics: Advances in Drug Delivery, Comparative Innovations, and Biomedical Applications.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"mRNA-Based Therapeutics: Advances in Drug Delivery, Comparative Innovations, and Biomedical Applications."
5783,17577,41472645,10.1021/acsbiomaterials.5c01786,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticle-Hydrogel Sustained-Release System for the Delivery of si-NEDD4: A Promising Strategy for the Treatment of Keloids.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticle-Hydrogel Sustained-Release System for the Delivery of si-NEDD4: A Promising Strategy for the Treatment of Keloids.
5792,17620,41460035,10.1080/17425247.2025.2609680,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: What role might nanolipogels play in enhancing drug delivery?",B,high_candidate,curator_rejected,reject,derived_annotations_only,What role might nanolipogels play in enhancing drug delivery?
5803,17667,41451635,10.1021/acsnano.5c13501,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Redox-Responsive Peptide Coacervates for Enhanced mRNA Delivery and Intracellular Release.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Redox-Responsive Peptide Coacervates for Enhanced mRNA Delivery and Intracellular Release.
5812,17722,41422812,10.1016/S2213-8587(25)00290-6,assay,siRNA,PubMed abstract sentence 21,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Zodasiran, an RNAi therapeutic targeting ANGPTL3, for treating patients with homozygous familial hypercholesterolaemia (GATEWAY): an open-label, randomised, phase 2 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Zodasiran, an RNAi therapeutic targeting ANGPTL3, for treating patients with homozygous familial hypercholesterolaemia (GATEWAY): an open-label, randomised, phase 2 trial."
5816,17756,41418602,10.1016/j.vaccine.2025.128116,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Mucosal delivery (in ovo and oral) of chitosan nanoparticle-based subunit vaccine enhances resistance against Campylobacter jejuni colonization in broiler chickens.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mucosal delivery (in ovo and oral) of chitosan nanoparticle-based subunit vaccine enhances resistance against Campylobacter jejuni colonization in broiler chickens.
5828,17792,41411050,10.1172/jci.insight.194759,benchmark,ASO/siRNA,PubMed abstract sentence 1,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Splice modulation of COL4A5 reinstates collagen IV assembly in an organoid model of Alport syndrome.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Splice modulation of COL4A5 reinstates collagen IV assembly in an organoid model of Alport syndrome.
5831,17809,41404643,10.1039/d5mh01468a,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Dendrimers with a far-red NDI fluorescent core for efficient and traceable gene and RNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dendrimers with a far-red NDI fluorescent core for efficient and traceable gene and RNA delivery.
5833,17813,41404475,10.1039/d5na00581g,delivery,ASO/siRNA,PubMed abstract sentence 8,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Nanoparticle-delivered miR-486-5p inhibits H(2)O(2)-induced injury in cultured endothelial and kidney tubular epithelial cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticle-delivered miR-486-5p inhibits H(2)O(2)-induced injury in cultured endothelial and kidney tubular epithelial cells.
5834,17814,41404475,10.1039/d5na00581g,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoparticle-delivered miR-486-5p inhibits H(2)O(2)-induced injury in cultured endothelial and kidney tubular epithelial cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanoparticle-delivered miR-486-5p inhibits H(2)O(2)-induced injury in cultured endothelial and kidney tubular epithelial cells.
5846,17864,41371528,10.1016/j.ijbiomac.2025.149468,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Discovery of selective TLR9 antagonists via machine learning-driven structural modeling and experimental validation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Discovery of selective TLR9 antagonists via machine learning-driven structural modeling and experimental validation.
5848,17868,41371500,10.1016/j.jconrel.2025.114517,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Guanidinylated polymers enable safe and efficient dsRNA delivery in plant cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Guanidinylated polymers enable safe and efficient dsRNA delivery in plant cells.
5849,17869,41371500,10.1016/j.jconrel.2025.114517,toxicity,ASO/siRNA,PubMed abstract sentence 1,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Guanidinylated polymers enable safe and efficient dsRNA delivery in plant cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Guanidinylated polymers enable safe and efficient dsRNA delivery in plant cells.
5850,17878,41367202,10.1039/d5nh00726g,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: CpG-induced immune responses via DNA micelles, gold nanoparticles, and liposomes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"CpG-induced immune responses via DNA micelles, gold nanoparticles, and liposomes."
5862,17964,41347908,10.1002/adma.202518041,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lock-and-Shield Strategy Enables Stable and Stimuli-Responsive Tumor-Targeted Gene Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lock-and-Shield Strategy Enables Stable and Stimuli-Responsive Tumor-Targeted Gene Delivery.
5870,18002,41338305,10.1016/j.micpath.2025.108217,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Antimicrobial and therapeutic effect of gold Nanoparticle-Aptamer conjugated antimicrobial peptide RW-BP100 in Brucella canis infected mice and RAW 264.7 cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antimicrobial and therapeutic effect of gold Nanoparticle-Aptamer conjugated antimicrobial peptide RW-BP100 in Brucella canis infected mice and RAW 264.7 cells.
5879,18071,41317822,10.1016/j.actbio.2025.11.055,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Self-assembled polymeric nanoparticles for redox- and gene-regulated Osteoarthritis therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Self-assembled polymeric nanoparticles for redox- and gene-regulated Osteoarthritis therapy.
5882,18086,41312764,10.1002/ps.70405,toxicity,siRNA,PubMed abstract sentence 6,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Targeting the Tret1 gene in Myzus persicae: RNAi-mediated crop protection through bacteria-synthesized dsRNA and nanocarrier delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting the Tret1 gene in Myzus persicae: RNAi-mediated crop protection through bacteria-synthesized dsRNA and nanocarrier delivery.
5886,18098,41297477,10.1016/j.biomaterials.2025.123862,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Nano-in-microalgae integrated modular hydrogel system for spatiotemporally targeted oral gene therapy of ulcerative colitis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nano-in-microalgae integrated modular hydrogel system for spatiotemporally targeted oral gene therapy of ulcerative colitis.
5888,18116,41285012,10.1039/d5tb02193f,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Engineering polymeric micelles for targeted drug delivery: ""click"" chemistry enabled bioconjugation strategies and emerging applications.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Engineering polymeric micelles for targeted drug delivery: ""click"" chemistry enabled bioconjugation strategies and emerging applications."
5890,18128,41275719,10.1016/j.talanta.2025.129136,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Parallel detection of okadaic acid and saxitoxin in mussels with an electrochemical aptamer-based assay.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Parallel detection of okadaic acid and saxitoxin in mussels with an electrochemical aptamer-based assay.
5894,18134,41275672,10.1016/j.colsurfb.2025.115289,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanotechnology-driven targeted pulmonary drug delivery: Innovations, insights, and clinical horizons.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Nanotechnology-driven targeted pulmonary drug delivery: Innovations, insights, and clinical horizons."
5903,18165,41270217,10.1002/advs.202510500,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Targeting the SOX9/TIMP1 Axis with iRGD-Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting the SOX9/TIMP1 Axis with iRGD-Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer.
5909,18191,41260121,10.1016/j.bios.2025.118239,assay,ASO/siRNA,PubMed abstract sentence 1,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Enzyme-linked lectin assay for amplified electrochemical detection of HPV DNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enzyme-linked lectin assay for amplified electrochemical detection of HPV DNA.
5915,18213,41247040,10.1002/ps.70366,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advancing pest control: evaluating the effectiveness of RNAi and the BenPol delivery platform for Lucilia cuprina.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advancing pest control: evaluating the effectiveness of RNAi and the BenPol delivery platform for Lucilia cuprina.
5924,18274,41211943,10.1056/NEJMoa2508827,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: A Phase 2 Trial of Tobevibart plus Elebsiran in Hepatitis D.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Phase 2 Trial of Tobevibart plus Elebsiran in Hepatitis D.
5926,18280,41211611,10.1002/ps.70341,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;route,"delivery candidate; matched derived terms: nanoparticle, route; source title: Pectin-coated hollow organosilicon construction of a dual pH and pectinase stimulation-responsive prochloraz delivery system for the control of rice sheath blight.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pectin-coated hollow organosilicon construction of a dual pH and pectinase stimulation-responsive prochloraz delivery system for the control of rice sheath blight.
5927,18281,41211611,10.1002/ps.70341,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Pectin-coated hollow organosilicon construction of a dual pH and pectinase stimulation-responsive prochloraz delivery system for the control of rice sheath blight.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pectin-coated hollow organosilicon construction of a dual pH and pectinase stimulation-responsive prochloraz delivery system for the control of rice sheath blight.
5929,18285,41208771,10.1002/adhm.202503947,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Dual-Nanocomplex Delivery of Neoantigen Vaccines and Doxorubicin for Synergistic Chemo-Immunotherapy against Colorectal Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dual-Nanocomplex Delivery of Neoantigen Vaccines and Doxorubicin for Synergistic Chemo-Immunotherapy against Colorectal Cancer.
5939,18329,41189396,10.1002/adma.202410507,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: siAkt2-Loaded Nanoparticles Reprogramming Macrophages to M2 Phenotype for Effective Bone Defect Repair.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siAkt2-Loaded Nanoparticles Reprogramming Macrophages to M2 Phenotype for Effective Bone Defect Repair.
5950,18372,41172904,10.1016/j.bios.2025.118175,offtarget,ASO/siRNA,PubMed abstract sentence 5,hybridization;mismatch,"offtarget candidate; matched derived terms: hybridization, mismatch; source title: Exploring bi-recycled strand displacement to cascade mismatch-mediated hairpin assembly for amplified electrochemical biosensing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exploring bi-recycled strand displacement to cascade mismatch-mediated hairpin assembly for amplified electrochemical biosensing.
5953,18383,41167182,10.1515/cclm-2025-0824,assay,ASO/siRNA,PubMed abstract sentence 3,screen;experiment,"assay candidate; matched derived terms: screen, experiment; source title: A robust ddPCR assay for the absolute quantification of miR-192-5p in hepatocellular carcinoma liquid biopsies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A robust ddPCR assay for the absolute quantification of miR-192-5p in hepatocellular carcinoma liquid biopsies.
5962,18412,41143502,10.1093/biolre/ioaf242,assay,ASO/siRNA,PubMed abstract sentence 2,screen;rna-seq;trial,"assay candidate; matched derived terms: screen, rna-seq, trial; source title: Microfibrillar-associated protein 5 promotes TGF-β1-induced endometrial epithelial fibrosis in intrauterine adhesion†.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Microfibrillar-associated protein 5 promotes TGF-β1-induced endometrial epithelial fibrosis in intrauterine adhesion†.
5963,18421,41135150,10.1016/j.virol.2025.110713,delivery,siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: RNAi therapeutics targeting Japanese encephalitis virus: Gene targets, delivery platforms, and translational barriers.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"RNAi therapeutics targeting Japanese encephalitis virus: Gene targets, delivery platforms, and translational barriers."
5967,18439,41124812,10.1016/j.biomaterials.2025.123784,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Cationic lipid-modified PEG-PLGA nanoparticles facilitate effective dendritic cell reprogramming to alleviate T cell-mediated autoimmunity in EAE.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cationic lipid-modified PEG-PLGA nanoparticles facilitate effective dendritic cell reprogramming to alleviate T cell-mediated autoimmunity in EAE.
5984,18504,41056522,10.1182/bloodadvances.2025017601,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Phase 1 study of rogocekib in patients with relapsed or refractory hematologic malignancies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Phase 1 study of rogocekib in patients with relapsed or refractory hematologic malignancies.
5989,18529,41039747,10.1002/adhm.202502835,delivery,ASO,PubMed abstract sentence 5,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: A Galactose-Engineered Dual-Responsive Nanocarrier for ASO/CRISPR-Cas9 Delivery to Inhibit HBV Replication.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Galactose-Engineered Dual-Responsive Nanocarrier for ASO/CRISPR-Cas9 Delivery to Inhibit HBV Replication.
5993,18547,41028674,10.1007/978-1-0716-4738-7_2,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: DG9-Conjugated Morpholino Rescues Phenotype in Spinal Muscular Atrophy Mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,DG9-Conjugated Morpholino Rescues Phenotype in Spinal Muscular Atrophy Mice.
6001,18585,40985298,10.1111/pbi.70378,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: High-Efficiency and Eco-Friendly Management of Multiple Fungal Diseases by a Novel Carbon Dots sCDP Delivered RNA Nano-Pesticides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,High-Efficiency and Eco-Friendly Management of Multiple Fungal Diseases by a Novel Carbon Dots sCDP Delivered RNA Nano-Pesticides.
6012,18630,40931580,10.1002/adhm.202503118,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: CD123 Targeted Epigenetic Nanotherapy for Fusion Oncoprotein MLL-AF9 Rearranged Acute Myeloid Leukemia in Preclinical and Patient Derived Xenograft Models.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CD123 Targeted Epigenetic Nanotherapy for Fusion Oncoprotein MLL-AF9 Rearranged Acute Myeloid Leukemia in Preclinical and Patient Derived Xenograft Models.
6032,18698,40816607,10.1016/j.ophtha.2025.07.039,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: A Randomized Sham-Controlled Phase 2/3 Trial of QPI-1007 for Acute Nonarteritic Anterior Ischemic Optic Neuropathy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Randomized Sham-Controlled Phase 2/3 Trial of QPI-1007 for Acute Nonarteritic Anterior Ischemic Optic Neuropathy.
6040,18730,40706481,10.1016/j.talanta.2025.128613,chemistry,ASO/siRNA,PubMed abstract sentence 7,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Microfluidic chip coupled with photoelectrochemical/fluorescence dual-modal sensing system for the efficient enrichment and detection of circulating tumor cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Microfluidic chip coupled with photoelectrochemical/fluorescence dual-modal sensing system for the efficient enrichment and detection of circulating tumor cells.
6044,18748,40658236,10.1007/s00210-025-04406-2,toxicity,ASO/siRNA,PubMed abstract sentence 4,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Optimizing cardiovascular health: a systematic review and meta-analysis of olezarsen dosages in high-risk hypertriglyceridemic patients.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Optimizing cardiovascular health: a systematic review and meta-analysis of olezarsen dosages in high-risk hypertriglyceridemic patients.
6045,18753,40627939,10.1016/j.saa.2025.126640,assay,ASO/siRNA,PubMed abstract sentence 6,screen;preclinical,"assay candidate; matched derived terms: screen, preclinical; source title: Machine learning-assisted SERS-based dual-aptamer biosensor for ultrasensitive clinical screening of breast cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Machine learning-assisted SERS-based dual-aptamer biosensor for ultrasensitive clinical screening of breast cancer.
6060,18834,41908870,10.3389/frph.2025.1733583,assay,ASO/siRNA,PubMed abstract sentence 3,model;trial,"assay candidate; matched derived terms: model, trial; source title: The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The role and underlying mechanisms of Qi Gong Wan in enhancing the endometrial receptivity of a rat model with polycystic ovary syndrome.
6071,18887,41599648,10.3390/ph19010047,assay,ASO/siRNA,PubMed abstract sentence 4,assay;model,"assay candidate; matched derived terms: assay, model; source title: Leveraging Acquired EGFR-TKI-Resistant Models to Identify MUC16 as a Therapeutic Vulnerability in Lung Adenocarcinoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Leveraging Acquired EGFR-TKI-Resistant Models to Identify MUC16 as a Therapeutic Vulnerability in Lung Adenocarcinoma.
6073,18893,41594586,10.3390/biom16010045,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Design of Anti-Tumor RNA Nanoparticles and Their Inhibitory Effect on Hep3B Liver Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Design of Anti-Tumor RNA Nanoparticles and Their Inhibitory Effect on Hep3B Liver Cancer.
6074,18894,41594586,10.3390/biom16010045,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Design of Anti-Tumor RNA Nanoparticles and Their Inhibitory Effect on Hep3B Liver Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Design of Anti-Tumor RNA Nanoparticles and Their Inhibitory Effect on Hep3B Liver Cancer.
6075,18897,41590784,10.3390/jfb17010015,assay,ASO/siRNA,PubMed abstract sentence 7,model;phase;trial,"assay candidate; matched derived terms: model, phase, trial; source title: Nanotherapy Targeting miR-10b Improves Survival in Orthotopic Glioblastoma Models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanotherapy Targeting miR-10b Improves Survival in Orthotopic Glioblastoma Models.
6077,18905,41586107,10.3389/fneur.2025.1582765,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: ATH-1105 mitigates multiple pathologies in ALS models both alone and in combination with riluzole.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,ATH-1105 mitigates multiple pathologies in ALS models both alone and in combination with riluzole.
6082,18924,41567850,10.62347/RGTY8619,assay,ASO/siRNA,PubMed abstract sentence 8,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: miRNA regulatory networks as precision diagnostic and therapeutic targets in pulmonary arterial hypertension: from molecular cascades to clinical translation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,miRNA regulatory networks as precision diagnostic and therapeutic targets in pulmonary arterial hypertension: from molecular cascades to clinical translation.
6091,19001,41479521,10.4254/wjh.v17.i12.113660,toxicity,ASO/siRNA,PubMed abstract sentence 16,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity.
6092,19004,41478672,10.1016/j.jpet.2025.103697,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Cell penetrating peptide-functionalized small interfering RNA nanoparticles knock down HER expression in breast cancer cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cell penetrating peptide-functionalized small interfering RNA nanoparticles knock down HER expression in breast cancer cells.
6103,19059,41465311,10.3390/ijms262411884,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Luteinizing Hormone-Releasing Hormone (LHRH)-Targeted Treatment in Ovarian Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Luteinizing Hormone-Releasing Hormone (LHRH)-Targeted Treatment in Ovarian Cancer.
6105,19067,41463150,10.3390/cancers17243899,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of PD-L1/PD-1 Checkpoint Increases NK Cell-Mediated Killing of Melanoma Cells in the Presence of Interferon-Beta.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of PD-L1/PD-1 Checkpoint Increases NK Cell-Mediated Killing of Melanoma Cells in the Presence of Interferon-Beta.
6106,19070,41463080,10.3390/biomedicines13123066,assay,ASO/siRNA,PubMed abstract sentence 2,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Translational Relevance of SCA1 Models for the Development of Therapies for Spinocerebellar Ataxia Type 1.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Translational Relevance of SCA1 Models for the Development of Therapies for Spinocerebellar Ataxia Type 1.
6110,19092,41457586,10.13345/j.cjb.250474,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: [DNA modification by sulfur: mechanistic insights drives synthetic biotechnologies forward].",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,[DNA modification by sulfur: mechanistic insights drives synthetic biotechnologies forward].
6121,19155,41437275,10.1186/s12967-025-07418-x,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cancer vaccine overcomes immune evasion of nasopharyngeal carcinoma by restoring MHC-I through transcriptional regulation of NLRC5.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cancer vaccine overcomes immune evasion of nasopharyngeal carcinoma by restoring MHC-I through transcriptional regulation of NLRC5.
6123,19171,41429715,10.1016/j.bbcan.2025.189480,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticulate delivery and targeting of RNA to the brain.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticulate delivery and targeting of RNA to the brain.
6131,19205,41419701,10.1007/s10278-025-01779-x,benchmark,ASO/siRNA,PubMed abstract sentence 6,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Multimodal Machine Learning Integrating N-13 Ammonia PET and Clinical Variables Predicts Major Adverse Cardiac Events.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multimodal Machine Learning Integrating N-13 Ammonia PET and Clinical Variables Predicts Major Adverse Cardiac Events.
6145,19255,41396041,10.17219/pim/211981,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: The historic development of plant virus-like particles as nanocarrier systems for bioactive molecules: Perspective and future opportunities.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The historic development of plant virus-like particles as nanocarrier systems for bioactive molecules: Perspective and future opportunities.
6148,19270,41393308,10.1016/j.omtn.2025.102697,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency.
6149,19273,41392621,10.1021/acsami.5c15253,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Modular Design of Mesoporous Silica Nanoparticles Enables Bioimaging, Dual Chemotherapy, and Combinatorial Gene Silencing in Triple-Negative Breast Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Modular Design of Mesoporous Silica Nanoparticles Enables Bioimaging, Dual Chemotherapy, and Combinatorial Gene Silencing in Triple-Negative Breast Cancer."
6153,19291,41388037,10.1038/s41598-025-27488-7,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Engineering filamentous potato virus X as a platform nanotechnology for nucleic acid gene delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineering filamentous potato virus X as a platform nanotechnology for nucleic acid gene delivery.
6157,19305,41385299,10.34067/KID.0000001109,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;risk;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, risk, hepatotoxicity; source title: Emerging Therapies in Autosomal Dominant Polycystic Kidney Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Emerging Therapies in Autosomal Dominant Polycystic Kidney Disease.
6163,19333,41373717,10.3390/ijms262311562,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Pomegranate and Cherry Leaf Extracts as Stabilizers of Magnetic Hydroxyapatite Nanocarriers for Nucleic Acid Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pomegranate and Cherry Leaf Extracts as Stabilizers of Magnetic Hydroxyapatite Nanocarriers for Nucleic Acid Delivery.
6165,19337,41373505,10.3390/ijms262311347,assay,ASO,PubMed abstract sentence 6,screen;model,"assay candidate; matched derived terms: screen, model; source title: Transferrin-Functionalized Liposomes Enhance MAPT-ASO Transport Across a 3D Blood-Brain Barrier Microvascular Network Model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transferrin-Functionalized Liposomes Enhance MAPT-ASO Transport Across a 3D Blood-Brain Barrier Microvascular Network Model.
6167,19341,41373402,10.3390/ijms262311241,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Preclinical Assessment in Transgenic NOD Mice of a Novel Immunotherapy for Type 1 Diabetes: Lipoplexes Down-Modulate the Murine C1858T Ptpn22 Variant In Vitro.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical Assessment in Transgenic NOD Mice of a Novel Immunotherapy for Type 1 Diabetes: Lipoplexes Down-Modulate the Murine C1858T Ptpn22 Variant In Vitro.
6170,19360,41366470,10.1186/s13046-025-03561-x,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;lnp,"delivery candidate; matched derived terms: delivery, lnp; source title: The simultaneous targeted Inhibition of ISG15 and HMGCR disrupts cancer stemness through metabolic collapse and induces synthetic lethality in pancreatic ductal adenocarcinoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The simultaneous targeted Inhibition of ISG15 and HMGCR disrupts cancer stemness through metabolic collapse and induces synthetic lethality in pancreatic ductal adenocarcinoma.
6176,19392,41354928,10.1186/s12951-025-03822-z,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Targeted nanodelivery strategies for atrial fibrillation: concomitant targeting of fibrosis suppression and electrical conduction restoration through advanced nanobiotechnology.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted nanodelivery strategies for atrial fibrillation: concomitant targeting of fibrosis suppression and electrical conduction restoration through advanced nanobiotechnology.
6177,19393,41354928,10.1186/s12951-025-03822-z,assay,ASO/siRNA,PubMed abstract sentence 1,model;trial,"assay candidate; matched derived terms: model, trial; source title: Targeted nanodelivery strategies for atrial fibrillation: concomitant targeting of fibrosis suppression and electrical conduction restoration through advanced nanobiotechnology.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted nanodelivery strategies for atrial fibrillation: concomitant targeting of fibrosis suppression and electrical conduction restoration through advanced nanobiotechnology.
6192,19464,41337582,10.1126/sciadv.adz5639,assay,ASO/siRNA,PubMed abstract sentence 2,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Distinguishing active HIV-1 infection from vaccine-induced seropositivity in HIV vaccine trial participants.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Distinguishing active HIV-1 infection from vaccine-induced seropositivity in HIV vaccine trial participants.
6195,19469,41337024,10.1109/EMBC58623.2025.11254222,benchmark,ASO/siRNA,PubMed abstract sentence 6,model;benchmark,"benchmark candidate; matched derived terms: model, benchmark; source title: A Novel Features-Driven Augmentation of DNA Methylation Microarrays to Enhance Meningioma Brain Tumors Classification using Transformer models.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Novel Features-Driven Augmentation of DNA Methylation Microarrays to Enhance Meningioma Brain Tumors Classification using Transformer models.
6199,19497,41323796,10.1016/j.omtn.2025.102757,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: SCAD: A modular platform for efficient delivery of duplex RNA to the CNS and beyond.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,SCAD: A modular platform for efficient delivery of duplex RNA to the CNS and beyond.
6212,19572,41306585,10.21769/BioProtoc.5511,delivery,ASO/siRNA,PubMed abstract sentence 2,conjugated;uptake,"delivery candidate; matched derived terms: conjugated, uptake; source title: Monitoring Endocytosis of Integral Membrane Proteins Using Western Blot-Based Detection of Biotinylated Antibody Uptake.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Monitoring Endocytosis of Integral Membrane Proteins Using Western Blot-Based Detection of Biotinylated Antibody Uptake.
6214,19584,41304838,10.3390/pharmaceutics17111502,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticles Used for the Delivery of RNAi-Based Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticles Used for the Delivery of RNAi-Based Therapeutics.
6219,19595,41303475,10.3390/ijms262210992,assay,ASO/siRNA,PubMed abstract sentence 5,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Cardiac Involvement in Myotonic Dystrophy Type 1: Mechanisms, Clinical Perspectives, and Emerging Therapeutic Strategies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Cardiac Involvement in Myotonic Dystrophy Type 1: Mechanisms, Clinical Perspectives, and Emerging Therapeutic Strategies."
6228,19630,41299461,10.1186/s12951-025-03782-4,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Peptide-functionalized periodic mesoporous silica nanoparticles for monocyte-specific TET3 Silencing enhance cardiac repair after acute myocardial infarction.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Peptide-functionalized periodic mesoporous silica nanoparticles for monocyte-specific TET3 Silencing enhance cardiac repair after acute myocardial infarction.
6231,19635,41297915,10.1021/jacs.5c12694,assay,ASO/siRNA,PubMed abstract sentence 2,screen;model;experiment,"assay candidate; matched derived terms: screen, model, experiment; source title: From Bits to Bonds: High-Throughput Virtual Screening of Ribonucleic Acid Nanocarriers Using a Combinatorial Approach of Machine Learning and Molecular Dynamics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,From Bits to Bonds: High-Throughput Virtual Screening of Ribonucleic Acid Nanocarriers Using a Combinatorial Approach of Machine Learning and Molecular Dynamics.
6234,19644,41295604,10.3390/nano15221695,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Development of Tumor Microenvironment-Responsive Nanoparticles with Enhanced Tissue Penetration.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of Tumor Microenvironment-Responsive Nanoparticles with Enhanced Tissue Penetration.
6244,19676,41291726,10.1186/s12967-025-07501-3,benchmark,ASO/siRNA,PubMed abstract sentence 5,model;prediction;benchmark;dataset,"benchmark candidate; matched derived terms: model, prediction, benchmark, dataset; source title: Context-aware gene dependency modeling via graph attention networks for precision oncology.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Context-aware gene dependency modeling via graph attention networks for precision oncology.
6246,19682,41291238,10.1038/s41570-025-00770-y,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Chemical strategies for brain delivery of genomic therapy.",C,high_candidate,curator_rejected,reject,derived_annotations_only,Chemical strategies for brain delivery of genomic therapy.
6256,19716,41286534,10.1007/s12035-025-05537-6,assay,ASO/siRNA,PubMed abstract sentence 5,assay;model,"assay candidate; matched derived terms: assay, model; source title: Functional Characterization and Expression Patterns of novel_circ_037817 in Schizophrenia Patients.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Functional Characterization and Expression Patterns of novel_circ_037817 in Schizophrenia Patients.
6257,19721,41285838,10.1038/s41598-025-25280-1,assay,ASO/siRNA,PubMed abstract sentence 7,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver.
6260,19726,41283736,10.1039/d5nr02199e,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Drug delivery systems for mitochondrial targeting.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Drug delivery systems for mitochondrial targeting.
6264,19746,41280480,10.1007/s13205-025-04617-7,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Advanced Nanoparticle-Based strategies for plant viral disease management: mechanisms and innovations for crop protection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advanced Nanoparticle-Based strategies for plant viral disease management: mechanisms and innovations for crop protection.
6266,19760,41278608,10.62347/WAHG9031,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Advances in cardiovascular gene therapy: a systematic review of nanoparticle-based delivery strategies for atherosclerosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in cardiovascular gene therapy: a systematic review of nanoparticle-based delivery strategies for atherosclerosis.
6267,19761,41278608,10.62347/WAHG9031,toxicity,ASO/siRNA,PubMed abstract sentence 2,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Advances in cardiovascular gene therapy: a systematic review of nanoparticle-based delivery strategies for atherosclerosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in cardiovascular gene therapy: a systematic review of nanoparticle-based delivery strategies for atherosclerosis.
6269,19767,41278142,10.1016/j.dib.2025.112211,benchmark,ASO/siRNA,PubMed abstract sentence 10,model;dataset,"benchmark candidate; matched derived terms: model, dataset; source title: Annotated drowsiness detection dataset captured using Raspberry Pi 5.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Annotated drowsiness detection dataset captured using Raspberry Pi 5.
6273,19791,41272938,10.1002/cbic.202500735,chemistry,ASO/siRNA,PubMed abstract sentence 6,chemical;modified;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: chemical, modified, phosphorothioate, 2'-o; source title: Discovery and Tuning of RNA Editing Guides via High-Throughput Screening and Chemical Modification.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Discovery and Tuning of RNA Editing Guides via High-Throughput Screening and Chemical Modification.
6280,19824,41262879,10.1155/humu/7388320,assay,ASO/siRNA,PubMed abstract sentence 7,model;rna-seq,"assay candidate; matched derived terms: model, rna-seq; source title: BCL6, DUSP3, and IL6R Are Identified as Shared Druggable Immune-Regulatory Axis in Atrial Fibrillation and Atherosclerosis Through Integrative In Silico and In Vitro Analysis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"BCL6, DUSP3, and IL6R Are Identified as Shared Druggable Immune-Regulatory Axis in Atrial Fibrillation and Atherosclerosis Through Integrative In Silico and In Vitro Analysis."
6282,19830,41262250,10.3389/fimmu.2025.1679092,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Bispecific immunotherapy based on antibodies, T-cell receptors, and aptamers: mechanisms of action, adverse effects, and future perspectives.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Bispecific immunotherapy based on antibodies, T-cell receptors, and aptamers: mechanisms of action, adverse effects, and future perspectives."
6287,19853,41259288,10.1021/acs.bioconjchem.5c00215,chemistry,ASO/siRNA,PubMed abstract sentence 5,modified;conjugate,"chemistry candidate; matched derived terms: modified, conjugate; source title: Aminoglycoside-Peptide Nucleic Acid (PNA) Conjugates against Gram-Negative Bacteria.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aminoglycoside-Peptide Nucleic Acid (PNA) Conjugates against Gram-Negative Bacteria.
6291,19869,41256290,10.1093/narmme/ugaf023,assay,ASO/siRNA,PubMed abstract sentence 2,screen;model,"assay candidate; matched derived terms: screen, model; source title: Characterization of DMPK and MBNL1 expression in cell models of myotonic dystrophy: a platform for drug screening.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Characterization of DMPK and MBNL1 expression in cell models of myotonic dystrophy: a platform for drug screening.
6315,19991,41226635,10.3390/ijms262110582,assay,siRNA,PubMed abstract sentence 10,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Anti-Angiogenic RNAi-Based Treatment of Endometriosis in a Rat Model Using CXCR4-Targeted Peptide Nanoparticles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Anti-Angiogenic RNAi-Based Treatment of Endometriosis in a Rat Model Using CXCR4-Targeted Peptide Nanoparticles.
6321,20015,41223275,10.1126/sciadv.ady0952,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Structure-guided design of nucleosome-inspired nanoparticles for overcoming pulmonary barriers in fibrotic lung gene therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structure-guided design of nucleosome-inspired nanoparticles for overcoming pulmonary barriers in fibrotic lung gene therapy.
6328,20048,41216350,10.2147/IJN.S544439,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Self-Assembled Safflower Polysaccharide Nanoparticles as a Targeted Drug Delivery System for Enhanced Therapy of Hepatocellular Carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Self-Assembled Safflower Polysaccharide Nanoparticles as a Targeted Drug Delivery System for Enhanced Therapy of Hepatocellular Carcinoma.
6329,20053,41214041,10.1038/s41598-025-22922-2,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: LINC02178 drives lung adenocarcinoma progression and serves as a therapeutic target for nanodelivery-based intervention.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,LINC02178 drives lung adenocarcinoma progression and serves as a therapeutic target for nanodelivery-based intervention.
6330,20054,41214041,10.1038/s41598-025-22922-2,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: LINC02178 drives lung adenocarcinoma progression and serves as a therapeutic target for nanodelivery-based intervention.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,LINC02178 drives lung adenocarcinoma progression and serves as a therapeutic target for nanodelivery-based intervention.
6333,20067,41212897,10.1021/acs.analchem.5c05880,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Aptamer-Gated Organic Photoelectrochemical Transistor Biosensor Based on a TiO(2)-Embedded Vertically Ordered Mesoporous SiO(2) Film for Sensitive Detection of Carcinoembryonic Antigen.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-Gated Organic Photoelectrochemical Transistor Biosensor Based on a TiO(2)-Embedded Vertically Ordered Mesoporous SiO(2) Film for Sensitive Detection of Carcinoembryonic Antigen.
6340,20112,41200756,10.1039/d5ay01354b,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;conjugate,"chemistry candidate; matched derived terms: modified, conjugate; source title: High-performance electrochemical aptasensor for CA 125 based on CuNP-decorated reduced graphene oxide.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-performance electrochemical aptasensor for CA 125 based on CuNP-decorated reduced graphene oxide.
6357,20193,41185634,10.1007/s12195-025-00853-2,delivery,ASO/siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Developing Nanoparticle-Based Therapeutics for Targeting the Microenvironment in Obesity-Induced Endometrial Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Developing Nanoparticle-Based Therapeutics for Targeting the Microenvironment in Obesity-Induced Endometrial Cancer.
6358,20194,41185634,10.1007/s12195-025-00853-2,assay,ASO/siRNA,PubMed abstract sentence 6,model;trial,"assay candidate; matched derived terms: model, trial; source title: Developing Nanoparticle-Based Therapeutics for Targeting the Microenvironment in Obesity-Induced Endometrial Cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Developing Nanoparticle-Based Therapeutics for Targeting the Microenvironment in Obesity-Induced Endometrial Cancer.
6363,20217,41180755,10.1097/MS9.0000000000003768,assay,ASO/siRNA,PubMed abstract sentence 5,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Olezarsen: FDA approval and clinical impact in familial chylomicronemia syndrome (FCS).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Olezarsen: FDA approval and clinical impact in familial chylomicronemia syndrome (FCS).
6370,20248,41168832,10.1186/s12967-025-07252-1,assay,ASO/siRNA,PubMed abstract sentence 8,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: Targeting lncRNA MALAT1 attenuates lenalidomide resistance via CD38 epigenetic modulation, oxidative stress-mediated cell death, and remodeling of the pro-tumor microenvironment in multiple myeloma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Targeting lncRNA MALAT1 attenuates lenalidomide resistance via CD38 epigenetic modulation, oxidative stress-mediated cell death, and remodeling of the pro-tumor microenvironment in multiple myeloma."
6386,20326,41155941,10.3390/pharmaceutics17101305,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: RNA Therapeutics: Delivery Problems and Solutions-A Review.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA Therapeutics: Delivery Problems and Solutions-A Review.
6402,20418,41135032,10.1200/JCO-25-01369,toxicity,ASO/siRNA,PubMed abstract sentence 9,safety;risk;tolerability,"toxicity candidate; matched derived terms: safety, risk, tolerability; source title: US Food and Drug Administration Approval Summary: Imetelstat for Selected Patients With Low- to Intermediate-1 Risk Myelodysplastic Syndromes With Transfusion-Dependent Anemia.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,US Food and Drug Administration Approval Summary: Imetelstat for Selected Patients With Low- to Intermediate-1 Risk Myelodysplastic Syndromes With Transfusion-Dependent Anemia.
6407,20437,41132349,10.21037/tau-2025-291,assay,ASO/siRNA,PubMed abstract sentence 5,screen;model,"assay candidate; matched derived terms: screen, model; source title: Machine learning-based screening of potential diagnostic markers for prostate cancer with immune cell infiltration analysis and experimental validation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Machine learning-based screening of potential diagnostic markers for prostate cancer with immune cell infiltration analysis and experimental validation.
6412,20476,41123738,10.1007/s10856-025-06936-w,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Construction of aptamer functionalized camptothecin incorporated chitosan-palladium/gold nanoparticles delivery improved photothermal activity and anti-lung carcinoma cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Construction of aptamer functionalized camptothecin incorporated chitosan-palladium/gold nanoparticles delivery improved photothermal activity and anti-lung carcinoma cells.
6413,20477,41123738,10.1007/s10856-025-06936-w,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Construction of aptamer functionalized camptothecin incorporated chitosan-palladium/gold nanoparticles delivery improved photothermal activity and anti-lung carcinoma cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Construction of aptamer functionalized camptothecin incorporated chitosan-palladium/gold nanoparticles delivery improved photothermal activity and anti-lung carcinoma cells.
6417,20489,41122806,10.1021/acs.analchem.5c04918,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: Environmental Health Risk Assessment of Dynamic Lipid Metabolism in PCB-118-Induced Insulin Resistance Models Using a Polarity-Ultrasensitive Fluorescent Probe.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Environmental Health Risk Assessment of Dynamic Lipid Metabolism in PCB-118-Induced Insulin Resistance Models Using a Polarity-Ultrasensitive Fluorescent Probe.
6420,20500,41120094,10.1039/d5an00916b,chemistry,ASO/siRNA,PubMed abstract sentence 5,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Electrochemical aptasensor based on Chrysanthemum indicum L.-derived carbon materials for detection of carcinoembryonic antigen.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Electrochemical aptasensor based on Chrysanthemum indicum L.-derived carbon materials for detection of carcinoembryonic antigen.
6423,20513,41115768,10.1136/heartjnl-2024-325280,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Ribonucleic acid and gene therapies in cardiovascular disease: clinical applications, delivery challenges and emerging precision tools.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Ribonucleic acid and gene therapies in cardiovascular disease: clinical applications, delivery challenges and emerging precision tools."
6424,20514,41115768,10.1136/heartjnl-2024-325280,assay,ASO/siRNA,PubMed abstract sentence 8,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Ribonucleic acid and gene therapies in cardiovascular disease: clinical applications, delivery challenges and emerging precision tools.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Ribonucleic acid and gene therapies in cardiovascular disease: clinical applications, delivery challenges and emerging precision tools."
6428,20522,41113669,10.3389/fmedt.2025.1655471,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exosome engineering for targeted therapy of brain-infecting pathogens: molecular tools, delivery platforms, and translational advances.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Exosome engineering for targeted therapy of brain-infecting pathogens: molecular tools, delivery platforms, and translational advances."
6429,20525,41112869,10.1021/acsnanoscienceau.5c00034,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Evasin and TSLPI Tick Salivary Antigen Subunit Vaccine Nanoparticles Induce Humoral and Cellular Immunity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evasin and TSLPI Tick Salivary Antigen Subunit Vaccine Nanoparticles Induce Humoral and Cellular Immunity.
6438,20560,41106101,10.1016/j.phymed.2025.157375,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Zexieyin formula attenuates Alzheimer's disease via suppressing A1 astrocyte activation: A serum pharmacochemistry and network pharmacology study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Zexieyin formula attenuates Alzheimer's disease via suppressing A1 astrocyte activation: A serum pharmacochemistry and network pharmacology study.
6449,20625,41088907,10.2174/0118722105390493250915211702,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A Review of Nanoparticle-Mediated Delivery Systems for RNA-Based Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Review of Nanoparticle-Mediated Delivery Systems for RNA-Based Therapeutics.
6450,20626,41088907,10.2174/0118722105390493250915211702,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Review of Nanoparticle-Mediated Delivery Systems for RNA-Based Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Review of Nanoparticle-Mediated Delivery Systems for RNA-Based Therapeutics.
6454,20656,41085163,10.1002/jcsm.70087,assay,ASO,PubMed abstract sentence 8,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: CXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide- and Dexamethasone-Induced Muscle Atrophy in Cultured Myotubes and Mouse Models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide- and Dexamethasone-Induced Muscle Atrophy in Cultured Myotubes and Mouse Models.
6459,20675,41082811,10.1016/j.vaccine.2025.127846,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Triple-TLR agonists' adjuvanted inactivated Newcastle disease virus vaccine promotes effective Th1/Th2 immune responses and affords protective efficacy in chickens.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Triple-TLR agonists' adjuvanted inactivated Newcastle disease virus vaccine promotes effective Th1/Th2 immune responses and affords protective efficacy in chickens.
6462,20700,41077776,10.1021/acsabm.5c01565,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Two-Dimensional Liquid Chromatography Method for Assembly Homogeneity Analysis and Mass Spectrometric Characterization of RNA Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Two-Dimensional Liquid Chromatography Method for Assembly Homogeneity Analysis and Mass Spectrometric Characterization of RNA Nanoparticles.
6464,20710,41075697,10.1016/j.bbrc.2025.152773,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Systemic dual delivery of a tumor-inhibiting plasmid expressing p16 and shRaf.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Systemic dual delivery of a tumor-inhibiting plasmid expressing p16 and shRaf.
6466,20718,41075454,10.1016/j.ejca.2025.116040,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Specific targeting of the pseudogene RPSAP52 reduces ovarian tumor growth in patient-derived orthoxenograft models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Specific targeting of the pseudogene RPSAP52 reduces ovarian tumor growth in patient-derived orthoxenograft models.
6468,20722,41075357,10.1016/j.retram.2025.103545,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Revolutionizing pediatric gene and cell therapy: The hope for lipid-based nanoparticles in blood disorders.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Revolutionizing pediatric gene and cell therapy: The hope for lipid-based nanoparticles in blood disorders.
6475,20743,41068915,10.1186/s12943-025-02463-y,assay,ASO/siRNA,PubMed abstract sentence 7,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Advances in RNA-based cancer therapeutics: pre-clinical and clinical implications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in RNA-based cancer therapeutics: pre-clinical and clinical implications.
6479,20765,41060642,10.1021/acs.biomac.5c00919,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Rational Design of DNA Nanostructures as TLR9 Agonists.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rational Design of DNA Nanostructures as TLR9 Agonists.
6482,20780,41056639,10.1016/j.biopha.2025.118566,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Membrane-coated BLM gene silencing plasmids and doxorubicin nanoparticles targeted for synergistic inhibition of triple-negative breast cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Membrane-coated BLM gene silencing plasmids and doxorubicin nanoparticles targeted for synergistic inhibition of triple-negative breast cancer.
6502,20854,41046076,10.1016/j.bcp.2025.117376,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Cancer-associated transporters: Molecular drivers and drug delivery gateways.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cancer-associated transporters: Molecular drivers and drug delivery gateways.
6511,20899,41035287,10.1021/acs.jafc.5c08250,delivery,ASO/siRNA,PubMed abstract sentence 6,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Standardized Synergistic Strategy for Insect Growth Regulators: Incorporation of RNA Pesticides via a Co-Delivery Nanoplatform Achieves High Control Efficacy with Low-Dosage Application.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Standardized Synergistic Strategy for Insect Growth Regulators: Incorporation of RNA Pesticides via a Co-Delivery Nanoplatform Achieves High Control Efficacy with Low-Dosage Application.
6512,20900,41035287,10.1021/acs.jafc.5c08250,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Standardized Synergistic Strategy for Insect Growth Regulators: Incorporation of RNA Pesticides via a Co-Delivery Nanoplatform Achieves High Control Efficacy with Low-Dosage Application.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Standardized Synergistic Strategy for Insect Growth Regulators: Incorporation of RNA Pesticides via a Co-Delivery Nanoplatform Achieves High Control Efficacy with Low-Dosage Application.
6527,20981,41021291,10.1039/d5bm01104c,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Mimicking the osteosarcoma surfaceome on nanoparticles for targeted gene therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mimicking the osteosarcoma surfaceome on nanoparticles for targeted gene therapy.
6532,20994,41020263,10.1016/j.omtm.2025.101585,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Design of cationic ionizable lipids for the delivery of therapeutic nucleic acids.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Design of cationic ionizable lipids for the delivery of therapeutic nucleic acids.
6542,21034,41012432,10.3390/pharmaceutics17091094,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lysozyme Amyloid for Synthetic RNA Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lysozyme Amyloid for Synthetic RNA Delivery.
6545,21065,41006757,10.1038/s42003-025-08772-8,assay,ASO/siRNA,PubMed abstract sentence 3,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Isolation, characterization and testing of RNA aptamers targeting glutamate receptors in a rat spinal cord injury pain model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Isolation, characterization and testing of RNA aptamers targeting glutamate receptors in a rat spinal cord injury pain model."
6549,21081,41004573,10.1126/sciadv.adx2681,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH.
6556,21120,40997974,10.1016/j.ijbiomac.2025.147854,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: RNA nanoparticles: Emerging biomolecular scaffolds for precision diagnostics and targeted therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA nanoparticles: Emerging biomolecular scaffolds for precision diagnostics and targeted therapeutics.
6561,21157,40988331,10.1111/1750-3841.70571,chemistry,ASO/siRNA,PubMed abstract sentence 5,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: An Electrochemical Aptamer-Based (E-AB) Sensor Using Ti(3)C(2)T(x)(MXene) and cDNA-PAA for Detection of AFB1.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,An Electrochemical Aptamer-Based (E-AB) Sensor Using Ti(3)C(2)T(x)(MXene) and cDNA-PAA for Detection of AFB1.
6564,21166,40987379,10.1016/j.actatropica.2025.107848,assay,ASO/siRNA,PubMed abstract sentence 3,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Efficacy assessment of a novel and two licensed Leishmania vaccines intended for dogs in an experimental hamster challenge model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficacy assessment of a novel and two licensed Leishmania vaccines intended for dogs in an experimental hamster challenge model.
6573,21195,40978076,10.2147/JMDH.S539699,assay,ASO/siRNA,PubMed abstract sentence 7,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Clinical Research for Inherited Retinal Disease Related Pediatric Blindness: A Preliminary Descriptive Analysis Based on ClinicalTrials.gov.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clinical Research for Inherited Retinal Disease Related Pediatric Blindness: A Preliminary Descriptive Analysis Based on ClinicalTrials.gov.
6574,21204,40975846,10.1007/s00604-025-07506-1,chemistry,ASO/siRNA,PubMed abstract sentence 5,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Detection of malachite green by electrochemical sensor constructed from modified high-affinity aptamer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Detection of malachite green by electrochemical sensor constructed from modified high-affinity aptamer.
6575,21207,40975509,10.1016/j.cellsig.2025.112148,assay,ASO/siRNA,PubMed abstract sentence 1,model;trial,"assay candidate; matched derived terms: model, trial; source title: LRRc17-RANKL pathway regulates mitophagy and contributes to atrial remodeling in diabetes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,LRRc17-RANKL pathway regulates mitophagy and contributes to atrial remodeling in diabetes.
6579,21213,40975447,10.1016/j.ijpharm.2025.126169,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Stimuli-responsive liposomes and niosomes in leukemia therapy: targeted delivery and clinical translation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Stimuli-responsive liposomes and niosomes in leukemia therapy: targeted delivery and clinical translation.
6580,21216,40975443,10.1016/j.ijpharm.2025.126189,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;lnp,"delivery candidate; matched derived terms: delivery, lnp; source title: Small nucleic acid therapeutics: delivery breakthroughs, clinical translation, and future paradigms in precision medicine.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Small nucleic acid therapeutics: delivery breakthroughs, clinical translation, and future paradigms in precision medicine."
6583,21225,40974940,10.1016/j.scitotenv.2025.180493,delivery,siRNA,PubMed abstract sentence 7,delivery;nanoparticle;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, uptake; source title: From stability to persistence: Insights into nanoparticle-formulated dsRNA in RNAi-based fungal disease control.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,From stability to persistence: Insights into nanoparticle-formulated dsRNA in RNAi-based fungal disease control.
6589,21265,40965836,10.1097/EJA.0000000000002256,assay,ASO/siRNA,PubMed abstract sentence 10,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: MRGPRX2 Triggers rocuronium bromide-induced peri-operative phase allergic shock: A case report with case control study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MRGPRX2 Triggers rocuronium bromide-induced peri-operative phase allergic shock: A case report with case control study.
6590,21268,40965079,10.1002/smll.202505680,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Natural Killer Cell-Mimicking Hypoxia-Responsive Nanomedicines for Tumor-Specific Suppression and Immune Regulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Natural Killer Cell-Mimicking Hypoxia-Responsive Nanomedicines for Tumor-Specific Suppression and Immune Regulation.
6592,21276,40963922,10.7150/thno.115496,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aptamer-based drug delivery for targeted therapy of imatinib-resistant gastrointestinal stromal tumor.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamer-based drug delivery for targeted therapy of imatinib-resistant gastrointestinal stromal tumor.
6593,21283,40963234,10.1080/0886022X.2025.2557019,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Astragaloside IV reduces diabetic kidney injury by inhibiting the PKC/NOX4/MAPK pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Astragaloside IV reduces diabetic kidney injury by inhibiting the PKC/NOX4/MAPK pathway.
6596,21296,40961169,10.1371/journal.ppat.1013533,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A single amino acid variant in the variable region I of AAV capsid confers liver detargeting.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A single amino acid variant in the variable region I of AAV capsid confers liver detargeting.
6599,21307,40959076,10.3389/fimmu.2025.1620390,assay,ASO/siRNA,PubMed abstract sentence 6,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: Liquid-liquid phase separation in gastric cancer: identifying novel biomarkers and therapeutic targets through gene signature analysis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Liquid-liquid phase separation in gastric cancer: identifying novel biomarkers and therapeutic targets through gene signature analysis.
6603,21321,40956616,10.1172/JCI193956,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Open-label phase IV trial evaluating nusinersen after onasemnogene abeparvovec in children with spinal muscular atrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Open-label phase IV trial evaluating nusinersen after onasemnogene abeparvovec in children with spinal muscular atrophy.
6606,21330,40953655,10.1016/j.fsi.2025.110877,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A comparative review of RNAi delivery systems for shrimp aquaculture and future directions.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A comparative review of RNAi delivery systems for shrimp aquaculture and future directions.
6613,21381,40942007,10.3390/molecules30173479,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Biologics as Therapeutical Agents Under Perspective Clinical Studies for Alzheimer's Disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Biologics as Therapeutical Agents Under Perspective Clinical Studies for Alzheimer's Disease.
6617,21401,40939664,10.1016/j.ijantimicag.2025.107617,toxicity,ASO/siRNA,PubMed abstract sentence 4,safety;risk;adverse,"toxicity candidate; matched derived terms: safety, risk, adverse; source title: Evaluation of the effect of two adjuvants co-administered with nasal recombinant hemagglutinin influenza vaccine on immune cells in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluation of the effect of two adjuvants co-administered with nasal recombinant hemagglutinin influenza vaccine on immune cells in mice.
6623,21429,40932871,10.3389/fphar.2025.1645634,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Berberine protects against gefitinib-induced liver injury by inhibiting the HMGB1/TLR4/NF-κB pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Berberine protects against gefitinib-induced liver injury by inhibiting the HMGB1/TLR4/NF-κB pathway.
6627,21451,40930163,10.1016/j.jconrel.2025.114192,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Hydrodynamic focusing to synthesize lipid-based nanoparticles: Computational and experimental analysis of chip design and formulation parameters.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hydrodynamic focusing to synthesize lipid-based nanoparticles: Computational and experimental analysis of chip design and formulation parameters.
6628,21454,40930161,10.1016/j.jconrel.2025.114198,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Pulmonary delivery of small circular RNA vaccines for influenza prevention.",C,high_candidate,curator_rejected,reject,derived_annotations_only,Pulmonary delivery of small circular RNA vaccines for influenza prevention.
6635,21469,40928544,10.1007/s10142-025-01692-0,assay,ASO/siRNA,PubMed abstract sentence 6,assay;model,"assay candidate; matched derived terms: assay, model; source title: Key copper homeostasis genes and inflammatory mechanisms in ischemic stroke: A bioinformatics and experimental study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Key copper homeostasis genes and inflammatory mechanisms in ischemic stroke: A bioinformatics and experimental study.
6637,21483,40925520,10.1016/j.addr.2025.115685,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aptamers as target-specific recognition elements in drug delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamers as target-specific recognition elements in drug delivery.
6640,21498,40923283,10.1039/d5lc00156k,assay,ASO/siRNA,PubMed abstract sentence 1,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Preclinical assessment of pan-influenza A virus CRISPR RNA therapeutics in a human lung alveolus chip.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical assessment of pan-influenza A virus CRISPR RNA therapeutics in a human lung alveolus chip.
6649,21557,40915452,10.1016/j.ijbiomac.2025.147380,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Polysaccharide copolymeric conjugates and their applications in targeted cancer therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Polysaccharide copolymeric conjugates and their applications in targeted cancer therapy.
6650,21558,40915452,10.1016/j.ijbiomac.2025.147380,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Polysaccharide copolymeric conjugates and their applications in targeted cancer therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Polysaccharide copolymeric conjugates and their applications in targeted cancer therapy.
6666,21638,40898653,10.1002/smll.202502667,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Engineered Bionanomaterials for Precision Delivery of Nucleic Acid Drugs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered Bionanomaterials for Precision Delivery of Nucleic Acid Drugs.
6670,21656,40896585,10.1016/j.omtn.2025.102644,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNAi delivery mediated by milk extracellular vesicles in colon cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RNAi delivery mediated by milk extracellular vesicles in colon cancer.
6675,21679,40891081,10.1021/acs.est.5c04320,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Perfluorodecanoic Acid (PFDA) Disrupts Immune Regulation via the Toll-like Receptor Signaling Pathway in Zebrafish.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Perfluorodecanoic Acid (PFDA) Disrupts Immune Regulation via the Toll-like Receptor Signaling Pathway in Zebrafish.
6684,21716,40884558,10.1093/eurheartj/ehaf685,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Inclisiran-based treatment strategy in hypercholesterolaemia: the VICTORION-Difference trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inclisiran-based treatment strategy in hypercholesterolaemia: the VICTORION-Difference trial.
6690,21740,40881396,10.1021/jacsau.5c00592,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synergistic Effect of Guanidinium and Tertiary Amine Groups on Boosting Gene Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synergistic Effect of Guanidinium and Tertiary Amine Groups on Boosting Gene Delivery.
6691,21743,40880664,10.1039/d5cb00137d,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;modification;phosphorothioate;2'-o;2'-moe,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate, 2'-o, 2'-moe; source title: Characterization of nuclease stability and poly(A)-binding protein binding activity of chemically modified poly(A) tail for in vivo applications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Characterization of nuclease stability and poly(A)-binding protein binding activity of chemically modified poly(A) tail for in vivo applications.
6694,21754,40879532,10.1177/21593337251371708,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: In Vivo Phage Display for the Identification of Muscle Homing Peptides to Improve the Delivery of Phosphorodiamidate Morpholino Oligomers for Duchenne Muscular Dystrophy Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vivo Phage Display for the Identification of Muscle Homing Peptides to Improve the Delivery of Phosphorodiamidate Morpholino Oligomers for Duchenne Muscular Dystrophy Therapy.
6697,21765,40878212,10.1039/d5tb01565k,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Competitive electrochemical assay of CA19-9 on gold nanoparticles/porous carbons nanohybrid amplified by polyoxometalate/aptamer/graphene quantum dot-decorated gold nanotags.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Competitive electrochemical assay of CA19-9 on gold nanoparticles/porous carbons nanohybrid amplified by polyoxometalate/aptamer/graphene quantum dot-decorated gold nanotags.
6705,21795,40874945,10.1002/asia.202500684,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Non-Viral Gene Delivery Systems: Current Advances and Therapeutic Applications.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Non-Viral Gene Delivery Systems: Current Advances and Therapeutic Applications.
6715,21847,40867568,10.3390/biom15081123,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Aptamer-Coated PLGA Nanoparticles Selectively Internalize into Epithelial Ovarian Cancer Cells In Vitro and In Vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-Coated PLGA Nanoparticles Selectively Internalize into Epithelial Ovarian Cancer Cells In Vitro and In Vivo.
6716,21850,40867257,10.3390/cancers17162628,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticle-Based Delivery Strategies for Combating Drug Resistance in Cancer Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticle-Based Delivery Strategies for Combating Drug Resistance in Cancer Therapeutics.
6721,21885,40858890,10.1038/s41598-025-17382-7,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipid membrane-camouflaged biomimetic nanoparticle for MicroRNA based therapeutic delivery to intestinal epithelial cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid membrane-camouflaged biomimetic nanoparticle for MicroRNA based therapeutic delivery to intestinal epithelial cells.
6722,21886,40858890,10.1038/s41598-025-17382-7,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid membrane-camouflaged biomimetic nanoparticle for MicroRNA based therapeutic delivery to intestinal epithelial cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid membrane-camouflaged biomimetic nanoparticle for MicroRNA based therapeutic delivery to intestinal epithelial cells.
6725,21897,40858064,10.1016/j.bbrc.2025.152512,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: RNA drugs and nonviral nanocarriers in oncology - present status and emerging concepts.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA drugs and nonviral nanocarriers in oncology - present status and emerging concepts.
6726,21900,40857430,10.1002/adfm.202508291,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Microbubble-Controlled Delivery of Biofilm-Targeting Nanoparticles to Treat MRSA Infection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Microbubble-Controlled Delivery of Biofilm-Targeting Nanoparticles to Treat MRSA Infection.
6728,21908,40855408,10.1186/s10020-025-01324-0,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CpG-oligodeoxynucleotides challenged macrophages ameliorate acetaminophen induced liver injury by activating TLR9/IRG1/itaconate metabolic pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CpG-oligodeoxynucleotides challenged macrophages ameliorate acetaminophen induced liver injury by activating TLR9/IRG1/itaconate metabolic pathway.
6733,21931,40851970,10.1097/MS9.0000000000003393,assay,ASO/siRNA,PubMed abstract sentence 6,preclinical;phase;trial,"assay candidate; matched derived terms: preclinical, phase, trial; source title: Fazirsiran for the treatment of alpha-1 antitrypsin deficiency-associated liver disease findings from the SEQUOIA phase 2 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Fazirsiran for the treatment of alpha-1 antitrypsin deficiency-associated liver disease findings from the SEQUOIA phase 2 trial.
6737,21965,40843962,10.1002/ardp.70083,assay,ASO/siRNA,PubMed abstract sentence 9,screen;model;trial,"assay candidate; matched derived terms: screen, model, trial; source title: Harnessing PHGDH Inhibition for Cancer Therapy: Mechanisms, SAR, Computational Aspects, and Clinical Potential.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Harnessing PHGDH Inhibition for Cancer Therapy: Mechanisms, SAR, Computational Aspects, and Clinical Potential."
6739,21995,40838562,10.1002/adhm.202503262,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Harnessing Biomaterials for Gene Therapy in Autoimmune Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Harnessing Biomaterials for Gene Therapy in Autoimmune Disease.
6742,22018,40832628,10.1016/j.omtn.2025.102650,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A short peptide for efficient cellular mRNA delivery: A potential application for inducing an immune response.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A short peptide for efficient cellular mRNA delivery: A potential application for inducing an immune response.
6751,22071,40819924,10.16288/j.yczz.24-378,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Progress on nucleos(t)idyl lipid-based nanoparticles for nucleic acid drugs delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Progress on nucleos(t)idyl lipid-based nanoparticles for nucleic acid drugs delivery.
6752,22072,40819924,10.16288/j.yczz.24-378,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Progress on nucleos(t)idyl lipid-based nanoparticles for nucleic acid drugs delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Progress on nucleos(t)idyl lipid-based nanoparticles for nucleic acid drugs delivery.
6769,22163,40803052,10.1016/j.dmd.2025.100127,chemistry,ASO/siRNA,PubMed abstract sentence 14,galnac;lna,"chemistry candidate; matched derived terms: galnac, lna; source title: Nonclinical absorption, distribution, metabolism, excretion and biomarkers properties of a modified N-acetylgalactosamine-conjugated small-interfering RNA for hypercholesteremia.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Nonclinical absorption, distribution, metabolism, excretion and biomarkers properties of a modified N-acetylgalactosamine-conjugated small-interfering RNA for hypercholesteremia."
6775,22183,40796541,10.1038/s41467-025-61965-x,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Dual-targeted siRubicon delivery strategy triggers hepatocellular lipophagy for mitigating liver steatosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dual-targeted siRubicon delivery strategy triggers hepatocellular lipophagy for mitigating liver steatosis.
6781,22205,40792157,10.21037/tcr-2024-2472,assay,ASO/siRNA,PubMed abstract sentence 3,screen;model,"assay candidate; matched derived terms: screen, model; source title: Integrative analysis of CRISPR screening and gene expression data identifies a three-gene prognostic model associated with immune microenvironment in neuroblastoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Integrative analysis of CRISPR screening and gene expression data identifies a three-gene prognostic model associated with immune microenvironment in neuroblastoma.
6783,22207,40792157,10.21037/tcr-2024-2472,benchmark,ASO/siRNA,PubMed abstract sentence 7,model;dataset,"benchmark candidate; matched derived terms: model, dataset; source title: Integrative analysis of CRISPR screening and gene expression data identifies a three-gene prognostic model associated with immune microenvironment in neuroblastoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Integrative analysis of CRISPR screening and gene expression data identifies a three-gene prognostic model associated with immune microenvironment in neuroblastoma.
6790,22232,40787487,10.1097/MS9.0000000000003505,toxicity,ASO/siRNA,PubMed abstract sentence 15,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: The impact of olezarsen on hypertriglyceridemia in high cardiovascular risk patients: a systematic review, meta-analysis, and meta-regression.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"The impact of olezarsen on hypertriglyceridemia in high cardiovascular risk patients: a systematic review, meta-analysis, and meta-regression."
6800,22280,40779068,10.1007/s00259-025-07493-8,assay,ASO/siRNA,PubMed abstract sentence 3,preclinical;experiment,"assay candidate; matched derived terms: preclinical, experiment; source title: Synthesis and preclinical evaluation of a (68)Ga-labeled peptide for PET imaging of transferrin receptor 1 in tumor.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synthesis and preclinical evaluation of a (68)Ga-labeled peptide for PET imaging of transferrin receptor 1 in tumor.
6801,22287,40777739,10.1016/j.omtn.2025.102625,chemistry,ASO/siRNA,PubMed abstract sentence 6,phosphorothioate;2'-o,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o; source title: Using muscle homing peptide CyPep10 to deliver phosphorodiamidate morpholino oligomers in the mdx mouse.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Using muscle homing peptide CyPep10 to deliver phosphorodiamidate morpholino oligomers in the mdx mouse.
6806,22302,40773798,10.1016/j.cancergen.2025.08.001,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Genetic silencing of CDC6 via AAV2-Delivered shRNA as a novel cancer genetics-based therapy for cervical carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Genetic silencing of CDC6 via AAV2-Delivered shRNA as a novel cancer genetics-based therapy for cervical carcinoma.
6819,22361,40761305,10.1093/ehjimp/qyaf088,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: MiR-132 inhibition improves myocardial strain in a large animal model of chronic left ventricular adverse remodelling.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MiR-132 inhibition improves myocardial strain in a large animal model of chronic left ventricular adverse remodelling.
6820,22362,40761305,10.1093/ehjimp/qyaf088,toxicity,ASO/siRNA,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: MiR-132 inhibition improves myocardial strain in a large animal model of chronic left ventricular adverse remodelling.",B,high_candidate,curator_rejected,reject,derived_annotations_only,MiR-132 inhibition improves myocardial strain in a large animal model of chronic left ventricular adverse remodelling.
6833,22429,40746423,10.3389/fmolb.2025.1637230,assay,ASO/siRNA,PubMed abstract sentence 11,screen;model;experiment,"assay candidate; matched derived terms: screen, model, experiment; source title: Development of a human colorectal carcinoma cell-based platform for studying inducible nitric oxide synthase expression and nitric oxide signaling dynamics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of a human colorectal carcinoma cell-based platform for studying inducible nitric oxide synthase expression and nitric oxide signaling dynamics.
6834,22432,40745699,10.1021/jacs.5c08345,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: The Overlooked Stereoisomers of the Ionizable Lipid ALC315.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Overlooked Stereoisomers of the Ionizable Lipid ALC315.
6838,22456,40740767,10.3389/fimmu.2025.1562107,assay,ASO/siRNA,PubMed abstract sentence 4,screen;model,"assay candidate; matched derived terms: screen, model; source title: IL-2 and IL-15 augment HBV therapeutic vaccination and PD1 blockade for functional cure in the AAV-HBV mouse model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,IL-2 and IL-15 augment HBV therapeutic vaccination and PD1 blockade for functional cure in the AAV-HBV mouse model.
6842,22464,40738442,10.1016/j.ijbiomac.2025.146366,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Novel macropinocytosis inducers selectively modulate intracellular delivery of small and macromolecules in cancer cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Novel macropinocytosis inducers selectively modulate intracellular delivery of small and macromolecules in cancer cells.
6844,22472,40736404,10.1021/acsami.5c10486,delivery,ASO,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Breaking Tumor Chemoresistance via METTL3 Regulation Enhanced by Sequential Delivery of Dexamethasone.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Breaking Tumor Chemoresistance via METTL3 Regulation Enhanced by Sequential Delivery of Dexamethasone.
6845,22473,40736404,10.1021/acsami.5c10486,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Breaking Tumor Chemoresistance via METTL3 Regulation Enhanced by Sequential Delivery of Dexamethasone.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Breaking Tumor Chemoresistance via METTL3 Regulation Enhanced by Sequential Delivery of Dexamethasone.
6846,22476,40735483,10.3389/fphar.2025.1554631,toxicity,ASO/siRNA,PubMed abstract sentence 3,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Systemic evaluation of inclisiran on the risk of new-onset diabetes and hyperglycemia compared to evolocumab and atorvastatin.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Systemic evaluation of inclisiran on the risk of new-onset diabetes and hyperglycemia compared to evolocumab and atorvastatin.
6857,22521,40727394,10.2147/JEP.S524226,assay,ASO/siRNA,PubMed abstract sentence 6,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Exploring the Potential of HIV Integrase Inhibitors as Therapeutic Agents Against HSV and HCMV: A Molecular Docking Study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exploring the Potential of HIV Integrase Inhibitors as Therapeutic Agents Against HSV and HCMV: A Molecular Docking Study.
6869,22573,40720024,10.1007/978-1-0716-4730-1_17,assay,ASO/siRNA,PubMed abstract sentence 3,screen;model,"assay candidate; matched derived terms: screen, model; source title: A Novel Zebrafish Model for Assessing In Vivo Delivery of Morpholino Oligomers.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Novel Zebrafish Model for Assessing In Vivo Delivery of Morpholino Oligomers.
6873,22585,40720010,10.1007/978-1-0716-4730-1_3,assay,ASO/siRNA,PubMed abstract sentence 5,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: An Overview of Recent Advances and Clinical Applications of Exon Skipping and Splice Modulation for Muscular Dystrophy and Various Genetic Diseases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,An Overview of Recent Advances and Clinical Applications of Exon Skipping and Splice Modulation for Muscular Dystrophy and Various Genetic Diseases.
6877,22603,40714929,10.1002/ctm2.70418,benchmark,ASO/siRNA,PubMed abstract sentence 4,model;dataset,"benchmark candidate; matched derived terms: model, dataset; source title: A robust machine learning model based on ribosomal-subunit-derived piRNAs for diagnostic potential of nonsmall cell lung cancer across multicentre, large-scale of sequencing data.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A robust machine learning model based on ribosomal-subunit-derived piRNAs for diagnostic potential of nonsmall cell lung cancer across multicentre, large-scale of sequencing data."
6878,22606,40714759,10.1002/smll.202501304,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Cyclodextrin-Based Pseudocopolymers and Their Biomedical Applications for Drug and Gene Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cyclodextrin-Based Pseudocopolymers and Their Biomedical Applications for Drug and Gene Delivery.
6879,22607,40714759,10.1002/smll.202501304,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cyclodextrin-Based Pseudocopolymers and Their Biomedical Applications for Drug and Gene Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cyclodextrin-Based Pseudocopolymers and Their Biomedical Applications for Drug and Gene Delivery.
6892,22652,40706921,10.1016/j.ijbiomac.2025.146217,delivery,siRNA,PubMed abstract sentence 6,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Exercise-imitating adipocyte targeted poly-Lipidic DendroRNAi Nanovesicles for gene silencing-guided treatment of obesity in high-fat diet mouse model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exercise-imitating adipocyte targeted poly-Lipidic DendroRNAi Nanovesicles for gene silencing-guided treatment of obesity in high-fat diet mouse model.
6896,22666,40705155,10.1007/s10637-025-01558-z,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Comparative analysis of engineered-exosome delivered si-HER2 and trastuzumab in the treatment of HER2-positive gastric cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comparative analysis of engineered-exosome delivered si-HER2 and trastuzumab in the treatment of HER2-positive gastric cancer.
6898,22682,40702295,10.1208/s12249-025-03159-8,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanovesicular Drug Delivery Systems for Rare Ocular Diseases: Advances, Challenges, and Future Directions.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Nanovesicular Drug Delivery Systems for Rare Ocular Diseases: Advances, Challenges, and Future Directions."
6905,22703,40700608,10.1093/molehr/gaaf032,assay,ASO/siRNA,PubMed abstract sentence 6,model;trial,"assay candidate; matched derived terms: model, trial; source title: Down-regulation of IGFBP2 mediates endometrial epithelial cells senescence in thin endometrium.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Down-regulation of IGFBP2 mediates endometrial epithelial cells senescence in thin endometrium.
6912,22734,40695191,10.1016/j.seminoncol.2025.152371,benchmark,ASO/siRNA,PubMed abstract sentence 2,database;dataset,"benchmark candidate; matched derived terms: database, dataset; source title: Deciphering the prognostic value and immunotherapeutic strategy of aggrephagy in melanoma: Integrating single-cell sequencing and machine learning.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Deciphering the prognostic value and immunotherapeutic strategy of aggrephagy in melanoma: Integrating single-cell sequencing and machine learning.
6916,22752,40692392,10.1002/smll.202504468,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted Delivery of miR-34a via Anti-CD47 Antibody Conjugates for Enhanced Cancer Immunotherapy in Triple Negative Breast Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted Delivery of miR-34a via Anti-CD47 Antibody Conjugates for Enhanced Cancer Immunotherapy in Triple Negative Breast Cancer.
6927,22797,40685636,10.1021/acs.jmedchem.5c00492,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Novel Aptamer-Drug Conjugate for Targeted Therapy in Triple-Negative Breast Cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel Aptamer-Drug Conjugate for Targeted Therapy in Triple-Negative Breast Cancer.
6935,22817,40683132,10.1016/j.prp.2025.156124,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle;conjugated,"delivery candidate; matched derived terms: delivery, nanoparticle, conjugated; source title: AS1411 aptamer in melanoma therapy: Harnessing targeted strategies for precision treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,AS1411 aptamer in melanoma therapy: Harnessing targeted strategies for precision treatment.
6943,22839,40679866,10.1681/ASN.0000000793,assay,ASO/siRNA,PubMed abstract sentence 12,screen;experiment,"assay candidate; matched derived terms: screen, experiment; source title: Identification of Epigenetic Regulators of Vascular Calcification with a CRISPR-Based Screen.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of Epigenetic Regulators of Vascular Calcification with a CRISPR-Based Screen.
6944,22846,40676731,10.1080/17435889.2025.2534321,delivery,ASO/siRNA,PubMed abstract sentence 10,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Emerging gene delivery nanosystems for the treatment of acute lung injury.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Emerging gene delivery nanosystems for the treatment of acute lung injury.
6956,22890,40668829,10.1073/pnas.2409266122,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.
6961,22913,40665962,10.2147/IJN.S520329,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Nanoformulations Downregulating METTL16 Combined with mRNA Tumor Vaccines Suppress Triple-Negative Breast Cancer and Prevent Metastasis.",C,high_candidate,curator_rejected,reject,derived_annotations_only,Nanoformulations Downregulating METTL16 Combined with mRNA Tumor Vaccines Suppress Triple-Negative Breast Cancer and Prevent Metastasis.
6968,22952,40661506,10.1101/2025.06.13.659546,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.
6969,22953,40661506,10.1101/2025.06.13.659546,assay,ASO/siRNA,PubMed abstract sentence 8,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.
6971,22955,40661506,10.1101/2025.06.13.659546,benchmark,ASO/siRNA,PubMed abstract sentence 8,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Swine reporter model for preclinical evaluation and characterization of gene delivery vectors.
6972,22960,40660011,10.1007/s12035-025-05200-0,assay,ASO/siRNA,PubMed abstract sentence 3,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: DTX1 Modulates Microglial M1 Polarization and Exacerbates Neuroinflammation in Traumatic Brain Injury Model Rats through NF-κB/IRF5.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,DTX1 Modulates Microglial M1 Polarization and Exacerbates Neuroinflammation in Traumatic Brain Injury Model Rats through NF-κB/IRF5.
6985,23015,40651599,10.1016/j.jconrel.2025.114031,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted delivery of therapeutics to metastatic lung cancer cells using aptamer-conjugated nanoemulsions.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted delivery of therapeutics to metastatic lung cancer cells using aptamer-conjugated nanoemulsions.
6990,23044,40643938,10.1637/aviandiseases-D-24-00093,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Induction of Trained Immunity in Broiler Chickens by Combination of in Ovo Delivery of Oligodeoxynucleotides Containing CpG Motifs and Intrapulmonary Delivery of a Live Clostridium perfringens Vaccine at Hatch to Protect Against Escherichia coli Septicemia Later in the Grow-Out Period.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Induction of Trained Immunity in Broiler Chickens by Combination of in Ovo Delivery of Oligodeoxynucleotides Containing CpG Motifs and Intrapulmonary Delivery of a Live Clostridium perfringens Vaccine at Hatch to Protect Against Escherichia coli Septicemia Later in the Grow-Out Period.
6992,23048,40643718,10.1007/s12672-025-03125-7,assay,ASO/siRNA,PubMed abstract sentence 9,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: SLC3A2 as a key anoikis-related gene for prognosis and tumor microenvironment remodeling in melanoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,SLC3A2 as a key anoikis-related gene for prognosis and tumor microenvironment remodeling in melanoma.
6996,23064,40641297,10.1002/advs.202506827,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy.
6998,23078,40640142,10.1038/s41467-025-61604-5,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications.
7002,23096,40636939,10.1039/d5pm00129c,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Breaking the cellular delivery bottleneck: recent developments in direct cytosolic delivery of biologics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Breaking the cellular delivery bottleneck: recent developments in direct cytosolic delivery of biologics.
7009,23127,40629260,10.1002/ps.70040,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: RNAi revolution in agriculture: unlocking mechanisms, overcoming delivery challenges, and advancing sustainable Pest control.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"RNAi revolution in agriculture: unlocking mechanisms, overcoming delivery challenges, and advancing sustainable Pest control."
7012,23134,40627883,10.1016/j.esmoop.2025.105498,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: CDK4/6 inhibition in advanced chordoma: final results of the NCT PMO-1601 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CDK4/6 inhibition in advanced chordoma: final results of the NCT PMO-1601 trial.
7016,23152,40625227,10.1002/advs.202507118,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Cascade-Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cascade-Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer.
7026,23200,40616517,10.1021/acs.molpharmaceut.5c00251,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Development of Inorganic and Hybrid Nanosystems for Delivery of CRISPR-Based Gene Editors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of Inorganic and Hybrid Nanosystems for Delivery of CRISPR-Based Gene Editors.
7028,23206,40615894,10.1186/s12951-025-03563-z,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Starlike Au nanoparticle unleashing siDDIT3 and photothermal power to combat ferroptosis - driven osteoarthritis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Starlike Au nanoparticle unleashing siDDIT3 and photothermal power to combat ferroptosis - driven osteoarthritis.
7032,23232,40609917,10.1016/j.bmcl.2025.130325,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;modification;modified,"chemistry candidate; matched derived terms: chemical, modification, modified; source title: Improvement of MNAzyme derived from 17EV1 by modification on the split catalytic core for biosensor design.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Improvement of MNAzyme derived from 17EV1 by modification on the split catalytic core for biosensor design.
7037,23257,40607511,10.1021/acsnano.5c04293,chemistry,ASO/siRNA,PubMed abstract sentence 7,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Chemical Composition and Backbone Modifications Define Deformability of Nucleic Acid Nanoparticles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical Composition and Backbone Modifications Define Deformability of Nucleic Acid Nanoparticles.
7038,23258,40607511,10.1021/acsnano.5c04293,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Chemical Composition and Backbone Modifications Define Deformability of Nucleic Acid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical Composition and Backbone Modifications Define Deformability of Nucleic Acid Nanoparticles.
7045,23293,40601241,10.1007/s40262-025-01540-1,assay,ASO/siRNA,PubMed abstract sentence 4,model;trial,"assay candidate; matched derived terms: model, trial; source title: Population Pharmacokinetic and Pharmacodynamic Modelling and Simulation for Nedosiran Clinical Development and Dose Guidance in Pediatric Patients with Primary Hyperoxaluria Type 1.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Population Pharmacokinetic and Pharmacodynamic Modelling and Simulation for Nedosiran Clinical Development and Dose Guidance in Pediatric Patients with Primary Hyperoxaluria Type 1.
7048,23306,40598254,10.1186/s12951-025-03560-2,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Novel adjuvant delivery system constructed by alum-emulsion hybrid nanoparticles with TLR9 agonists boosts vaccine immunity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel adjuvant delivery system constructed by alum-emulsion hybrid nanoparticles with TLR9 agonists boosts vaccine immunity.
7055,23327,40596461,10.1038/s41598-025-06380-4,benchmark,ASO/siRNA,PubMed abstract sentence 3,model;benchmark,"benchmark candidate; matched derived terms: model, benchmark; source title: Hybrid metaheuristic optimized Catboost models for construction cost estimation of concrete solid slabs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hybrid metaheuristic optimized Catboost models for construction cost estimation of concrete solid slabs.
7056,23332,40595741,10.1038/s41467-025-61023-6,benchmark,ASO/siRNA,PubMed abstract sentence 5,benchmark;dataset,"benchmark candidate; matched derived terms: benchmark, dataset; source title: ADTnorm: robust integration of single-cell protein measurement across CITE-seq datasets.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,ADTnorm: robust integration of single-cell protein measurement across CITE-seq datasets.
7057,23337,40594465,10.1038/s41598-025-05074-1,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Combined treatment using bismuth sulfide nanoparticles loaded with NANOG decoy oligodeoxynucleotides under X-ray radiation for breast cancer cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Combined treatment using bismuth sulfide nanoparticles loaded with NANOG decoy oligodeoxynucleotides under X-ray radiation for breast cancer cells.
7059,23349,40591889,10.1021/acsami.5c07018,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Hybrid Aptamer Molecularly Imprinted Polymer Nanoparticles for Reducing Oxidized Low-Density Lipoprotein Internalization by Macrophages.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hybrid Aptamer Molecularly Imprinted Polymer Nanoparticles for Reducing Oxidized Low-Density Lipoprotein Internalization by Macrophages.
7065,23387,40583319,10.1080/17435889.2025.2523730,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipid-polymer hybrid nanoparticles: a cutting-edge frontier in breast cancer treatment strategies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid-polymer hybrid nanoparticles: a cutting-edge frontier in breast cancer treatment strategies.
7070,23404,40581129,10.1016/j.ijpharm.2025.125902,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Aptamer-Drug Conjugates (ApDCs): Transformative approaches in targeted cancer therapy and precision oncology.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-Drug Conjugates (ApDCs): Transformative approaches in targeted cancer therapy and precision oncology.
7074,23422,40578633,10.1016/j.ijbiomac.2025.145514,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: MUC1 aptamer-functionalized chitosan nanoparticles: Targeted delivery platforms for synergistic cancer therapy and multidrug resistance overcoming.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MUC1 aptamer-functionalized chitosan nanoparticles: Targeted delivery platforms for synergistic cancer therapy and multidrug resistance overcoming.
7075,23423,40578633,10.1016/j.ijbiomac.2025.145514,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MUC1 aptamer-functionalized chitosan nanoparticles: Targeted delivery platforms for synergistic cancer therapy and multidrug resistance overcoming.",B,high_candidate,curator_rejected,reject,derived_annotations_only,MUC1 aptamer-functionalized chitosan nanoparticles: Targeted delivery platforms for synergistic cancer therapy and multidrug resistance overcoming.
7081,23447,40574101,10.3390/pharmaceutics17060789,delivery,ASO/siRNA,PubMed abstract sentence 11,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Intravenous Administration of sRNA Nanoparticles for Treatment of Osteoporosis in Mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intravenous Administration of sRNA Nanoparticles for Treatment of Osteoporosis in Mice.
7088,23484,40565310,10.3390/ijms26125850,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A Review of Silica-Based Nanoplatforms for Anticancer Cargo Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Review of Silica-Based Nanoplatforms for Anticancer Cargo Delivery.
7103,23545,40556451,10.1021/acsnano.5c05144,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Oral Administration of a Tetrahedral Framework DNA-Based Nanoshot Attenuates Liver Fibrosis via Targeting Galectin-3.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Oral Administration of a Tetrahedral Framework DNA-Based Nanoshot Attenuates Liver Fibrosis via Targeting Galectin-3.
7105,23553,40555853,10.1007/s11274-025-04454-z,chemistry,ASO/siRNA,PubMed abstract sentence 6,chemical;conjugate,"chemistry candidate; matched derived terms: chemical, conjugate; source title: Nucleic acid conjugated gold nanoparticles for biosensing applications: a review.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nucleic acid conjugated gold nanoparticles for biosensing applications: a review.
7106,23554,40555853,10.1007/s11274-025-04454-z,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Nucleic acid conjugated gold nanoparticles for biosensing applications: a review.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nucleic acid conjugated gold nanoparticles for biosensing applications: a review.
7116,23638,40535771,10.3389/fphar.2025.1586921,assay,ASO/siRNA,PubMed abstract sentence 6,assay;model,"assay candidate; matched derived terms: assay, model; source title: Palmitoylation-driven immune dysregulation and prognostic signature in low-grade glioma: a multi-omics and functional validation study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Palmitoylation-driven immune dysregulation and prognostic signature in low-grade glioma: a multi-omics and functional validation study.
7123,23683,40527861,10.1080/21645515.2025.2518634,delivery,ASO/siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A bibliometric analysis of challenges and advancements in the integrated application of nanoparticles and chimeric antigen receptor T cell therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A bibliometric analysis of challenges and advancements in the integrated application of nanoparticles and chimeric antigen receptor T cell therapy.
7131,23705,40523574,10.1016/j.actbio.2025.06.017,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Co-assembly of oligo-urethane nanoparticles with defined lipid additives to tailor RNA delivery into cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Co-assembly of oligo-urethane nanoparticles with defined lipid additives to tailor RNA delivery into cells.
7137,23741,40516722,10.1016/j.ijbiomac.2025.145236,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted delivery of doxorubicin toward 4 T1 cells via in situ binding between maleimide functionalized AS1411 - NH(2) aptamer and endogenous albumin.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted delivery of doxorubicin toward 4 T1 cells via in situ binding between maleimide functionalized AS1411 - NH(2) aptamer and endogenous albumin.
7142,23752,40514411,10.1038/s41434-025-00544-7,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aptamer-targeted anti-miR RNA construct based on 3WJ as a new approach for the treatment of chronic kidney disease in an experimental model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamer-targeted anti-miR RNA construct based on 3WJ as a new approach for the treatment of chronic kidney disease in an experimental model.
7144,23760,40513886,10.1016/j.addr.2025.115639,assay,ASO/siRNA,PubMed abstract sentence 6,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Aptamer-based applications in delivering cancer gene therapies and beyond: state of the art and the missing links to clinical translation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-based applications in delivering cancer gene therapies and beyond: state of the art and the missing links to clinical translation.
7149,23779,40509581,10.1002/adhm.202501411,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Intelligent Gene Delivery System Functionalized Metal Implants for Fracture Repair via Remodeling Mitochondrial Homeostasis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intelligent Gene Delivery System Functionalized Metal Implants for Fracture Repair via Remodeling Mitochondrial Homeostasis.
7153,23799,40505783,10.1016/j.nbd.2025.106999,assay,ASO/siRNA,PubMed abstract sentence 3,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Modulation of miR-145 in a mouse model of multiple sclerosis: A promising approach to attenuate inflammation and degeneration.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modulation of miR-145 in a mouse model of multiple sclerosis: A promising approach to attenuate inflammation and degeneration.
7159,23813,40503175,10.1016/j.omtn.2025.102567,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting CIDEB alleviates liver steatosis and fibrosis in mouse MASH models.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting CIDEB alleviates liver steatosis and fibrosis in mouse MASH models.
7165,23843,40499869,10.1016/j.ijbiomac.2025.145091,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipoplex-based RNA delivery system enhances RNAi efficiency for targeted Pest control in Spodoptera litura.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipoplex-based RNA delivery system enhances RNAi efficiency for targeted Pest control in Spodoptera litura.
7180,23904,40487670,10.1016/j.apsb.2025.03.033,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Inhaled non-viral delivery systems for RNA therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhaled non-viral delivery systems for RNA therapeutics.
7181,23905,40487670,10.1016/j.apsb.2025.03.033,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhaled non-viral delivery systems for RNA therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhaled non-viral delivery systems for RNA therapeutics.
7187,23921,40486136,10.1016/j.jhepr.2025.101400,assay,ASO/siRNA,PubMed abstract sentence 5,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Therapy with murinized tobevibart and elebsiran is efficacious in a liver-chimeric mouse model of HDV infection.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapy with murinized tobevibart and elebsiran is efficacious in a liver-chimeric mouse model of HDV infection.
7190,23930,40484286,10.1016/j.jneumeth.2025.110500,assay,ASO/siRNA,PubMed abstract sentence 3,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Development of high-content screening assay for gene silencing in adult sensory neurons.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of high-content screening assay for gene silencing in adult sensory neurons.
7194,23940,40482738,10.1016/j.ijbiomac.2025.144862,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic;safety;risk,"toxicity candidate; matched derived terms: toxicity, toxic, safety, risk; source title: A review of stimuli-responsive hydrogels for RNA delivery: From material innovations to clinical barriers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A review of stimuli-responsive hydrogels for RNA delivery: From material innovations to clinical barriers.
7202,23962,40480558,10.1016/j.ijbiomac.2025.144962,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Carrier-free Nanotherapeutics unleashed: Ce6/siPD-L1 co-delivery system synergizes photodynamic and RNAi therapies to combat breast cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Carrier-free Nanotherapeutics unleashed: Ce6/siPD-L1 co-delivery system synergizes photodynamic and RNAi therapies to combat breast cancer.
7209,23991,40470916,10.1002/jcph.70055,assay,ASO/siRNA,PubMed abstract sentence 1,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Population Pharmacokinetic Modeling of Subcutaneous Plozasiran in Healthy Volunteers and Patients with Familial Chylomicronemia Syndrome, Severe Hypertriglyceridemia, and Mixed Hyperlipidemia.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Population Pharmacokinetic Modeling of Subcutaneous Plozasiran in Healthy Volunteers and Patients with Familial Chylomicronemia Syndrome, Severe Hypertriglyceridemia, and Mixed Hyperlipidemia."
7224,24060,40455085,10.1021/acsnano.5c04036,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Virus-like Nanoparticles Deliver Small Interfering RNA to Pancreatic Cancer Cells through Filopodia-Mediated Internalization.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Virus-like Nanoparticles Deliver Small Interfering RNA to Pancreatic Cancer Cells through Filopodia-Mediated Internalization.
7225,24061,40455085,10.1021/acsnano.5c04036,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Virus-like Nanoparticles Deliver Small Interfering RNA to Pancreatic Cancer Cells through Filopodia-Mediated Internalization.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Virus-like Nanoparticles Deliver Small Interfering RNA to Pancreatic Cancer Cells through Filopodia-Mediated Internalization.
7226,24082,40449974,10.1016/bs.ai.2024.10.009,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nucleic acid delivery as a therapeutic approach for cancer immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nucleic acid delivery as a therapeutic approach for cancer immunotherapy.
7228,24086,40449637,10.1016/j.ijpharm.2025.125787,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nucleolin-targeted carbon/manganese nanoparticles for synergistic anti-tumor therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nucleolin-targeted carbon/manganese nanoparticles for synergistic anti-tumor therapy.
7230,24098,40446605,10.1016/j.foodchem.2025.144949,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Antifouling electrochemical aptasensor based on a polyzwitterion copolymer for analyzing aflatoxin B1 in food.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antifouling electrochemical aptasensor based on a polyzwitterion copolymer for analyzing aflatoxin B1 in food.
7232,24110,40444614,10.2174/0115665232367377250519114910,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Next-Generation Nucleic Acid Delivery: A Review of Nanobiosystem Design and Applications.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Next-Generation Nucleic Acid Delivery: A Review of Nanobiosystem Design and Applications.
7234,24114,40444266,10.34133/bmr.0209,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Reactive Oxygen Species-Responsive Ferrocene Nanoparticles Delivering Small Interfering RNA Targeting NOP2/Sun RNA Methyltransferase Family Member 2 for Gastric Cancer Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Reactive Oxygen Species-Responsive Ferrocene Nanoparticles Delivering Small Interfering RNA Targeting NOP2/Sun RNA Methyltransferase Family Member 2 for Gastric Cancer Therapy.
7235,24115,40444266,10.34133/bmr.0209,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Reactive Oxygen Species-Responsive Ferrocene Nanoparticles Delivering Small Interfering RNA Targeting NOP2/Sun RNA Methyltransferase Family Member 2 for Gastric Cancer Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Reactive Oxygen Species-Responsive Ferrocene Nanoparticles Delivering Small Interfering RNA Targeting NOP2/Sun RNA Methyltransferase Family Member 2 for Gastric Cancer Therapy.
7241,24143,40439254,10.1021/acs.bioconjchem.5c00069,delivery,ASO/siRNA,PubMed abstract sentence 10,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Multiprotein Silencing Using WRAP-Based Nanoparticles: A Proof of Concept.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multiprotein Silencing Using WRAP-Based Nanoparticles: A Proof of Concept.
7249,24173,40436133,10.1016/j.jinsphys.2025.104820,offtarget,ASO/siRNA,PubMed abstract sentence 4,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Evaluation of topical application as a delivery method of double-stranded RNA in Rhodnius prolixus (Hemiptera, Triatominae) for salivary gene silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Evaluation of topical application as a delivery method of double-stranded RNA in Rhodnius prolixus (Hemiptera, Triatominae) for salivary gene silencing."
7252,24188,40433973,10.1021/acsnano.4c16585,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Inflammatory Macrophage-Targeted Atherosclerosis Treatment by miRNA-Delivered, MRI-Visible, and Anti-Inflammatory Nanomedicine.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Inflammatory Macrophage-Targeted Atherosclerosis Treatment by miRNA-Delivered, MRI-Visible, and Anti-Inflammatory Nanomedicine."
7257,24203,40427711,10.3390/biology14050522,assay,ASO/siRNA,PubMed abstract sentence 8,screen;model;experiment,"assay candidate; matched derived terms: screen, model, experiment; source title: Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning.
7259,24207,40427146,10.3390/cancers17101648,delivery,ASO/siRNA,PubMed abstract sentence 10,delivery;nanoparticle;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, uptake; source title: Exosome Enveloped by Nano Lipid Particle a New Model for Signal Transducer and Activator of Transcription 3 Silencer Ribonucleic Acid Delivery System to a Glioblastoma Mice Model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exosome Enveloped by Nano Lipid Particle a New Model for Signal Transducer and Activator of Transcription 3 Silencer Ribonucleic Acid Delivery System to a Glioblastoma Mice Model.
7264,24220,40424612,10.1021/acsnano.5c05314,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted Knockdown of Epithelial Estrogen Receptor α to Mitigate Ferroptosis and Epithelial-Mesenchymal Transition in Eosinophilic Asthma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted Knockdown of Epithelial Estrogen Receptor α to Mitigate Ferroptosis and Epithelial-Mesenchymal Transition in Eosinophilic Asthma.
7267,24237,40419081,10.1016/j.canlet.2025.217823,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Therapeutic targeting of circTNK2 with nanoparticles restores tamoxifen sensitivity and enhances NK cell-mediated immunity in ER-positive breast cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic targeting of circTNK2 with nanoparticles restores tamoxifen sensitivity and enhances NK cell-mediated immunity in ER-positive breast cancer.
7269,24253,40413293,10.1038/s41434-025-00541-w,assay,siRNA,PubMed abstract sentence 3,model;trial,"assay candidate; matched derived terms: model, trial; source title: RNAi targeting heparin cofactor II promotes hemostasis in a canine model of acquired hemophilia A.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi targeting heparin cofactor II promotes hemostasis in a canine model of acquired hemophilia A.
7271,24257,40412647,10.1016/j.jinsphys.2025.104825,delivery,siRNA,PubMed abstract sentence 5,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Assessing nanoparticle-enabled dsRNA delivery for oral RNAi in two orthopteran pests: Schistocerca gregaria and Melanoplus sanguinipes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Assessing nanoparticle-enabled dsRNA delivery for oral RNAi in two orthopteran pests: Schistocerca gregaria and Melanoplus sanguinipes.
7278,24286,40404549,10.1016/j.actbio.2025.05.018,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Delivery of siGPX4 through a thiol-mediated pathway using a fluorinated cell-penetrating poly(disulfide) for inducing ferroptosis in breast cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of siGPX4 through a thiol-mediated pathway using a fluorinated cell-penetrating poly(disulfide) for inducing ferroptosis in breast cancer.
7279,24287,40404549,10.1016/j.actbio.2025.05.018,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Delivery of siGPX4 through a thiol-mediated pathway using a fluorinated cell-penetrating poly(disulfide) for inducing ferroptosis in breast cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery of siGPX4 through a thiol-mediated pathway using a fluorinated cell-penetrating poly(disulfide) for inducing ferroptosis in breast cancer.
7281,24291,40403699,10.1021/acs.bioconjchem.5c00022,assay,ASO/siRNA,PubMed abstract sentence 14,screen;model;experiment,"assay candidate; matched derived terms: screen, model, experiment; source title: Targeting HER2 with DNA Aptamers for Efficient Anticancer Drug Delivery: A Combined Experimental and Computational Study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting HER2 with DNA Aptamers for Efficient Anticancer Drug Delivery: A Combined Experimental and Computational Study.
7282,24292,40403699,10.1021/acs.bioconjchem.5c00022,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting HER2 with DNA Aptamers for Efficient Anticancer Drug Delivery: A Combined Experimental and Computational Study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting HER2 with DNA Aptamers for Efficient Anticancer Drug Delivery: A Combined Experimental and Computational Study.
7285,24305,40399967,10.1186/s12974-025-03466-8,assay,ASO/siRNA,PubMed abstract sentence 13,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Caveolin-1 negatively regulates the calcitonin receptor-like receptor and neuroinflammation in a female mouse model of migraine.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Caveolin-1 negatively regulates the calcitonin receptor-like receptor and neuroinflammation in a female mouse model of migraine.
7294,24328,40397061,10.1208/s12248-025-01070-5,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Improvement of Drug Release from an Aptamer Drug Conjugate Using Reductive-sensitive Linkers for Tumor-targeted Drug Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Improvement of Drug Release from an Aptamer Drug Conjugate Using Reductive-sensitive Linkers for Tumor-targeted Drug Delivery.
7296,24340,40394591,10.1186/s12951-025-03433-8,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Advancing cancer gene therapy: the emerging role of nanoparticle delivery systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advancing cancer gene therapy: the emerging role of nanoparticle delivery systems.
7318,24454,40366533,10.1007/s10637-025-01534-7,delivery,ASO/siRNA,PubMed abstract sentence 11,delivery;nanoparticle;conjugated,"delivery candidate; matched derived terms: delivery, nanoparticle, conjugated; source title: MicroRNA nanoformulation: a promising approach to anti-tumour activity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MicroRNA nanoformulation: a promising approach to anti-tumour activity.
7321,24463,40364115,10.3390/jcm14093083,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxic;risk;renal,"toxicity candidate; matched derived terms: toxic, risk, renal; source title: Risk Factors and Prevention of Cancer and CVDs: A Chicken and Egg Situation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Risk Factors and Prevention of Cancer and CVDs: A Chicken and Egg Situation.
7327,24483,40356455,10.1080/10837450.2025.2505000,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: An insight into cell-penetrating peptides: perspectives on design, optimization, and targeting in drug delivery systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"An insight into cell-penetrating peptides: perspectives on design, optimization, and targeting in drug delivery systems."
7330,24492,40351137,10.1002/chem.202500469,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Recent Cutting-Edge Technologies for the Delivery of Peptide Nucleic Acid.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent Cutting-Edge Technologies for the Delivery of Peptide Nucleic Acid.
7333,24505,40349901,10.1016/j.actbio.2025.05.025,delivery,ASO/siRNA,PubMed abstract sentence 11,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Dissolving microneedles for nucleic acid delivery: A systematic search, review, and data synthesis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Dissolving microneedles for nucleic acid delivery: A systematic search, review, and data synthesis."
7334,24506,40349901,10.1016/j.actbio.2025.05.025,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Dissolving microneedles for nucleic acid delivery: A systematic search, review, and data synthesis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Dissolving microneedles for nucleic acid delivery: A systematic search, review, and data synthesis."
7344,24544,40343577,10.1007/s11427-024-2887-x,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Inhibition of recurrence and metastasis in triple-negative breast cancer through nanoparticle-mediated silencing of LPCAT1 to remodel ATP energy metabolism.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhibition of recurrence and metastasis in triple-negative breast cancer through nanoparticle-mediated silencing of LPCAT1 to remodel ATP energy metabolism.
7348,24550,40342233,10.1002/ps.8880,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Chitosan nanoparticle-mediated delivery of dsRNA for enhancing RNAi efficiency in Locusta migratoria.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chitosan nanoparticle-mediated delivery of dsRNA for enhancing RNAi efficiency in Locusta migratoria.
7350,24556,40340000,10.1016/j.mcn.2025.104010,chemistry,ASO/siRNA,PubMed abstract sentence 8,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: RNA-based therapies for neurodegenerative disease: Targeting molecular mechanisms for disease modification.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA-based therapies for neurodegenerative disease: Targeting molecular mechanisms for disease modification.
7351,24559,40339610,10.1016/j.taap.2025.117376,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Ferritinophagy-derived iron causes protein nitration and mitochondrial dysfunction in acetaminophen-induced liver injury.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ferritinophagy-derived iron causes protein nitration and mitochondrial dysfunction in acetaminophen-induced liver injury.
7353,24569,40338193,10.1021/acsami.5c00802,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Dendritic Poly(l-lysine)-Based Nanoparticle Loading with siDNMT1 to Alleviate Basal Cell Carcinoma Progression by Inhibiting Methylation of AXIN2.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Dendritic Poly(l-lysine)-Based Nanoparticle Loading with siDNMT1 to Alleviate Basal Cell Carcinoma Progression by Inhibiting Methylation of AXIN2.
7363,24615,40325025,10.1038/s41467-025-59490-y,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance.
7365,24623,40319800,10.1016/j.scitotenv.2025.179576,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Aluminium oxide nanoparticles (Al(2)O(3)-NPs) exposure impairs cardiovascular physiology and elevates health risk - proteomic and molecular mechanistic insights.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aluminium oxide nanoparticles (Al(2)O(3)-NPs) exposure impairs cardiovascular physiology and elevates health risk - proteomic and molecular mechanistic insights.
7366,24628,40319421,10.1007/s12672-025-02497-0,assay,ASO/siRNA,PubMed abstract sentence 20,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Molecular and immune landscape of melanoma: a risk stratification model for precision oncology.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Molecular and immune landscape of melanoma: a risk stratification model for precision oncology.
7377,24673,40309219,10.15420/ecr.2024.61,assay,ASO/siRNA,PubMed abstract sentence 5,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Factor XI and Atrial Fibrillation: A Mismatched Pairing?",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Factor XI and Atrial Fibrillation: A Mismatched Pairing?
7382,24682,40306578,10.1016/j.jconrel.2025.113791,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Gemcitabine and miRNA34a mimic codelivery with magnetic nanoparticles enhanced anti-tumor effect against pancreatic cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Gemcitabine and miRNA34a mimic codelivery with magnetic nanoparticles enhanced anti-tumor effect against pancreatic cancer.
7383,24683,40306578,10.1016/j.jconrel.2025.113791,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gemcitabine and miRNA34a mimic codelivery with magnetic nanoparticles enhanced anti-tumor effect against pancreatic cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Gemcitabine and miRNA34a mimic codelivery with magnetic nanoparticles enhanced anti-tumor effect against pancreatic cancer.
7385,24691,40305619,10.1126/sciadv.adv9571,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Inhalable myofibroblast targeting nanoparticles for synergistic treatment of pulmonary fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhalable myofibroblast targeting nanoparticles for synergistic treatment of pulmonary fibrosis.
7392,24726,40295020,10.21873/invivo.13945,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;conjugate,"chemistry candidate; matched derived terms: chemical, conjugate; source title: Effect of DNA Aptamer Concentration on the Stability of PDA Nanoparticle-based Electrochemical Biosensor to Detect Glycated Albumin.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of DNA Aptamer Concentration on the Stability of PDA Nanoparticle-based Electrochemical Biosensor to Detect Glycated Albumin.
7395,24743,40289085,10.1186/s12964-025-02162-7,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: LAMA4(+) CD90(+) eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8(+) T cell senescence.",B,high_candidate,curator_rejected,reject,derived_annotations_only,LAMA4(+) CD90(+) eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8(+) T cell senescence.
7396,24746,40288873,10.1016/j.aca.2025.344032,chemistry,ASO/siRNA,PubMed abstract sentence 2,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Ultrasensitive detection of methamphetamine in environmental water bodies by an Au@carbon dots/chitosan nanocomposite modified electrochemical aptasensor.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ultrasensitive detection of methamphetamine in environmental water bodies by an Au@carbon dots/chitosan nanocomposite modified electrochemical aptasensor.
7401,24767,40284522,10.3390/pharmaceutics17040528,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Harnessing Extracellular Vesicles for Targeted Drug Delivery in Ovarian Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Harnessing Extracellular Vesicles for Targeted Drug Delivery in Ovarian Cancer.
7402,24768,40284522,10.3390/pharmaceutics17040528,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Harnessing Extracellular Vesicles for Targeted Drug Delivery in Ovarian Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Harnessing Extracellular Vesicles for Targeted Drug Delivery in Ovarian Cancer.
7404,24774,40283201,10.3390/life15040647,assay,ASO/siRNA,PubMed abstract sentence 11,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Pathophysiology, Clinical Heterogeneity, and Therapeutic Advances in Amyotrophic Lateral Sclerosis: A Comprehensive Review of Molecular Mechanisms, Diagnostic Challenges, and Multidisciplinary Management Strategies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Pathophysiology, Clinical Heterogeneity, and Therapeutic Advances in Amyotrophic Lateral Sclerosis: A Comprehensive Review of Molecular Mechanisms, Diagnostic Challenges, and Multidisciplinary Management Strategies."
7409,24787,40280966,10.1038/s41598-025-98663-z,benchmark,ASO/siRNA,PubMed abstract sentence 1,prediction;challenge,"benchmark candidate; matched derived terms: prediction, challenge; source title: Telomere-related gene risk model predicts prognostic and immune microenvironment alterations in prostate cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Telomere-related gene risk model predicts prognostic and immune microenvironment alterations in prostate cancer.
7418,24818,40275672,10.1177/22143602251329215,toxicity,ASO/siRNA,PubMed abstract sentence 3,hematological;tolerability,"toxicity candidate; matched derived terms: hematological, tolerability; source title: Liver function in X-linked myotubular myopathy and autosomal dominant centronuclear myopathy: Data of the unite-CNM study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Liver function in X-linked myotubular myopathy and autosomal dominant centronuclear myopathy: Data of the unite-CNM study.
7424,24844,40272903,10.1021/acsnano.5c04743,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Bone-Targeting Nucleic Acid Delivery Polymer Vector for Effective Therapy of Bone Metastasis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Bone-Targeting Nucleic Acid Delivery Polymer Vector for Effective Therapy of Bone Metastasis.
7426,24856,40266471,10.1007/s12032-025-02714-4,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Innovative PEGylated chitosan nanocarriers for co-delivery of doxorubicin and CpG in breast cancer therapy: Preparation, characterization, and immunotherapeutic potential.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Innovative PEGylated chitosan nanocarriers for co-delivery of doxorubicin and CpG in breast cancer therapy: Preparation, characterization, and immunotherapeutic potential."
7427,24857,40266471,10.1007/s12032-025-02714-4,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Innovative PEGylated chitosan nanocarriers for co-delivery of doxorubicin and CpG in breast cancer therapy: Preparation, characterization, and immunotherapeutic potential.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Innovative PEGylated chitosan nanocarriers for co-delivery of doxorubicin and CpG in breast cancer therapy: Preparation, characterization, and immunotherapeutic potential."
7432,24884,40259607,10.1002/smll.202407752,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted Tumor Microenvironment Delivery of Floxuridine Prodrug via Soluble Silica Nanoparticles in Malignant Melanoma as a Model for Aggressive Cancer Treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted Tumor Microenvironment Delivery of Floxuridine Prodrug via Soluble Silica Nanoparticles in Malignant Melanoma as a Model for Aggressive Cancer Treatment.
7433,24885,40259607,10.1002/smll.202407752,assay,ASO/siRNA,PubMed abstract sentence 7,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Targeted Tumor Microenvironment Delivery of Floxuridine Prodrug via Soluble Silica Nanoparticles in Malignant Melanoma as a Model for Aggressive Cancer Treatment.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted Tumor Microenvironment Delivery of Floxuridine Prodrug via Soluble Silica Nanoparticles in Malignant Melanoma as a Model for Aggressive Cancer Treatment.
7437,24899,40252728,10.1016/j.mucimm.2025.04.004,assay,ASO/siRNA,PubMed abstract sentence 8,screen;model,"assay candidate; matched derived terms: screen, model; source title: A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing.
7439,24905,40249652,10.1080/00498254.2025.2493620,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: In vivo inhibition of CYP2E1 fails to reduce pulegone-induced liver injury in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In vivo inhibition of CYP2E1 fails to reduce pulegone-induced liver injury in mice.
7445,24931,40241992,10.2147/DNND.S495536,assay,ASO/siRNA,PubMed abstract sentence 5,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Gene Editing for Duchenne Muscular Dystrophy: From Experimental Models to Emerging Therapies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Gene Editing for Duchenne Muscular Dystrophy: From Experimental Models to Emerging Therapies.
7450,24950,40238879,10.1126/sciadv.adt2752,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Hydrogen-induced disruption of the airway mucus barrier enhances nebulized RNA delivery to reverse pulmonary fibrosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hydrogen-induced disruption of the airway mucus barrier enhances nebulized RNA delivery to reverse pulmonary fibrosis.
7455,24981,40230622,10.1016/j.omtn.2025.102478,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Binding of G-quadruplex DNA and serum albumins by synthetic non-proteinogenic amino acids: Implications for c-Myc-related anticancer activity and drug delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Binding of G-quadruplex DNA and serum albumins by synthetic non-proteinogenic amino acids: Implications for c-Myc-related anticancer activity and drug delivery.
7458,24998,40225952,10.34133/bmr.0179,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Myofibroblast-Targeting Extracellular Vesicles: A Promising Platform for Cardiac Fibrosis Drug Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Myofibroblast-Targeting Extracellular Vesicles: A Promising Platform for Cardiac Fibrosis Drug Delivery.
7459,25009,40221835,10.1016/j.ymthe.2025.04.009,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Seltoplasmid promotes ulcer healing versus placebo for treating patients with chronic limb-threatening ischemia: HOPE CLTI-2 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Seltoplasmid promotes ulcer healing versus placebo for treating patients with chronic limb-threatening ischemia: HOPE CLTI-2 trial.
7464,25036,40215648,10.1016/j.biopha.2025.118045,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A comprehensive review on overcoming the multifaceted challenge of cancer multidrug resistance: The emerging role of mesoporous silica nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A comprehensive review on overcoming the multifaceted challenge of cancer multidrug resistance: The emerging role of mesoporous silica nanoparticles.
7469,25061,40206655,10.1016/j.omtn.2025.102502,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Inhibition of IFNAR-JAK signaling enhances tolerability and transgene expression of systemic non-viral DNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhibition of IFNAR-JAK signaling enhances tolerability and transgene expression of systemic non-viral DNA delivery.
7471,25071,40205959,10.1002/mabi.202400627,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Chitosan-Based Nanoparticles for Twist1 Knockdown in 4T1 Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chitosan-Based Nanoparticles for Twist1 Knockdown in 4T1 Cells.
7479,25107,40194497,10.1016/j.jenvman.2025.125228,chemistry,ASO/siRNA,PubMed abstract sentence 3,modification;modified,"chemistry candidate; matched derived terms: modification, modified; source title: Microwave-assisted modification of magnetic Mg/Al/Fe-LDH hydrotalcite for efficient arsenic removal from water.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Microwave-assisted modification of magnetic Mg/Al/Fe-LDH hydrotalcite for efficient arsenic removal from water.
7482,25118,40192175,10.1002/anie.202500247,delivery,ASO/siRNA,PubMed abstract sentence 3,conjugated;uptake,"delivery candidate; matched derived terms: conjugated, uptake; source title: New Transferrin Receptor-Targeting Conjugate Effectively Delivers DNA to Mouse Brain.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,New Transferrin Receptor-Targeting Conjugate Effectively Delivers DNA to Mouse Brain.
7483,25119,40192175,10.1002/anie.202500247,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: New Transferrin Receptor-Targeting Conjugate Effectively Delivers DNA to Mouse Brain.",B,high_candidate,curator_rejected,reject,derived_annotations_only,New Transferrin Receptor-Targeting Conjugate Effectively Delivers DNA to Mouse Brain.
7488,25148,40185318,10.1016/j.ahj.2025.03.019,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Design and Rationale of Lp(a)HORIZON Trial: Assessing the Effect of Lipoprotein(a) Lowering With Pelacarsen on Major Cardiovascular Events in Patients With CVD and Elevated Lp(a).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Design and Rationale of Lp(a)HORIZON Trial: Assessing the Effect of Lipoprotein(a) Lowering With Pelacarsen on Major Cardiovascular Events in Patients With CVD and Elevated Lp(a).
7493,25167,40180253,10.1016/j.bmcl.2025.130215,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Aptamer-modified GSH-degradable honokiol polyprodrug nanoparticles for ovarian cancer-specific targeting therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-modified GSH-degradable honokiol polyprodrug nanoparticles for ovarian cancer-specific targeting therapy.
7497,25185,40177349,10.3389/fchem.2025.1542504,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: DNA delivery into plant tissues using carbon dots made from citric acid and β-alanine.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,DNA delivery into plant tissues using carbon dots made from citric acid and β-alanine.
7498,25186,40177349,10.3389/fchem.2025.1542504,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: DNA delivery into plant tissues using carbon dots made from citric acid and β-alanine.",B,high_candidate,curator_rejected,reject,derived_annotations_only,DNA delivery into plant tissues using carbon dots made from citric acid and β-alanine.
7503,25213,40163298,10.1007/978-1-0716-4418-8_4,assay,siRNA,PubMed abstract sentence 1,screen;model,"assay candidate; matched derived terms: screen, model; source title: Integration of RNAi and Small Molecule Library Screens to Identify Targets for Drug Discovery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Integration of RNAi and Small Molecule Library Screens to Identify Targets for Drug Discovery.
7508,25228,40158211,10.1016/j.jacc.2025.03.005,assay,ASO/siRNA,PubMed abstract sentence 3,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Effect of ANGPTL3 Inhibition With Solbinsiran in Preclinical and Early Human Studies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of ANGPTL3 Inhibition With Solbinsiran in Preclinical and Early Human Studies.
7518,25270,40148126,10.1021/acs.bioconjchem.5c00065,delivery,ASO/siRNA,PubMed abstract sentence 3,conjugated;uptake,"delivery candidate; matched derived terms: conjugated, uptake; source title: Aptamer- vs Fab-Conjugated Liposomes: A Comparative Study in Targeting Acute Myeloid Leukemia Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer- vs Fab-Conjugated Liposomes: A Comparative Study in Targeting Acute Myeloid Leukemia Cells.
7525,25285,40145792,10.1002/advs.202414559,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS-Induced Depressive-Like Behaviors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS-Induced Depressive-Like Behaviors.
7533,25315,40138089,10.1007/s11427-025-2874-8,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment.
7534,25320,40135385,10.1002/smll.202412688,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Multifunctional Co-Delivery Systems with Downregulation of the Novel Target PIM1 in Macrophages to Ameliorate TF-Mediated Coagulopathy in Sepsis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multifunctional Co-Delivery Systems with Downregulation of the Novel Target PIM1 in Macrophages to Ameliorate TF-Mediated Coagulopathy in Sepsis.
7535,25321,40135385,10.1002/smll.202412688,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Multifunctional Co-Delivery Systems with Downregulation of the Novel Target PIM1 in Macrophages to Ameliorate TF-Mediated Coagulopathy in Sepsis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Multifunctional Co-Delivery Systems with Downregulation of the Novel Target PIM1 in Macrophages to Ameliorate TF-Mediated Coagulopathy in Sepsis.
7537,25331,40132387,10.1016/j.tranon.2025.102365,toxicity,ASO/siRNA,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In-vitro immune-modulation of triple-negative breast cancer through targeting miR-30a-5p/MALAT1 axis using nano-PDT combinational approach.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In-vitro immune-modulation of triple-negative breast cancer through targeting miR-30a-5p/MALAT1 axis using nano-PDT combinational approach.
7544,25356,40122885,10.1038/s41467-025-58179-6,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Bemcentinib as monotherapy and in combination with low-dose cytarabine in acute myeloid leukemia patients unfit for intensive chemotherapy: a phase 1b/2a trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Bemcentinib as monotherapy and in combination with low-dose cytarabine in acute myeloid leukemia patients unfit for intensive chemotherapy: a phase 1b/2a trial.
7548,25366,40117447,10.1021/acsami.4c21725,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: All-In-One Gadolinium-Doxorubicin Nanoassemblies for Spatial Delivery and Chemoresistance Reversal in Tumor Microenvironments.",B,high_candidate,curator_rejected,reject,derived_annotations_only,All-In-One Gadolinium-Doxorubicin Nanoassemblies for Spatial Delivery and Chemoresistance Reversal in Tumor Microenvironments.
7552,25386,40105473,10.1177/22143602251326993,assay,ASO/siRNA,PubMed abstract sentence 7,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Preclinical development of genome editing to treat Duchenne muscular dystrophy by exon skipping.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical development of genome editing to treat Duchenne muscular dystrophy by exon skipping.
7556,25404,40101873,10.1016/j.ijpharm.2025.125485,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;conjugated;lnp,"delivery candidate; matched derived terms: delivery, conjugated, lnp; source title: Development of a messenger RNA vaccine using pH-responsive dipeptide-conjugated lipids exhibiting reduced inflammatory properties.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of a messenger RNA vaccine using pH-responsive dipeptide-conjugated lipids exhibiting reduced inflammatory properties.
7560,25420,40093249,10.1101/2025.03.03.25322827,assay,ASO/siRNA,PubMed abstract sentence 7,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: KRAS (G12D) -Specific Targeting with Engineered Exosomes Reprograms the Immune Microenvironment to Enable Efficacy of Immune Checkpoint Therapy in PDAC Patients.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,KRAS (G12D) -Specific Targeting with Engineered Exosomes Reprograms the Immune Microenvironment to Enable Efficacy of Immune Checkpoint Therapy in PDAC Patients.
7561,25421,40093249,10.1101/2025.03.03.25322827,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: KRAS (G12D) -Specific Targeting with Engineered Exosomes Reprograms the Immune Microenvironment to Enable Efficacy of Immune Checkpoint Therapy in PDAC Patients.",B,high_candidate,curator_rejected,reject,derived_annotations_only,KRAS (G12D) -Specific Targeting with Engineered Exosomes Reprograms the Immune Microenvironment to Enable Efficacy of Immune Checkpoint Therapy in PDAC Patients.
7562,25424,40093067,10.1101/2025.03.04.641478,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A single amino acid variant in the variable region I of AAV capsid confers liver detargeting.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A single amino acid variant in the variable region I of AAV capsid confers liver detargeting.
7566,25442,40084851,10.1002/cmdc.202400885,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Enhancing WRAP-Based Nanoparticles for Small Interfering Ribonucleic Acid Delivery in pH-Sensitive Environments.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhancing WRAP-Based Nanoparticles for Small Interfering Ribonucleic Acid Delivery in pH-Sensitive Environments.
7570,25452,40082048,10.1016/j.pestbp.2025.106361,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PEI-SWNT improves RNAi efficiency in Locusta migratoria via dsRNA injection delivery system.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PEI-SWNT improves RNAi efficiency in Locusta migratoria via dsRNA injection delivery system.
7571,25459,40081744,10.1016/j.ahj.2025.02.022,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Olezarsen in patients with hypertriglyceridemia at high cardiovascular risk: Rationale and design of the Essence-TIMI 73b trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Olezarsen in patients with hypertriglyceridemia at high cardiovascular risk: Rationale and design of the Essence-TIMI 73b trial.
7572,25460,40081744,10.1016/j.ahj.2025.02.022,toxicity,ASO/siRNA,PubMed abstract sentence 15,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Olezarsen in patients with hypertriglyceridemia at high cardiovascular risk: Rationale and design of the Essence-TIMI 73b trial.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Olezarsen in patients with hypertriglyceridemia at high cardiovascular risk: Rationale and design of the Essence-TIMI 73b trial.
7575,25469,40078065,10.1039/d4nh00652f,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;conjugate,"chemistry candidate; matched derived terms: chemical, conjugate; source title: Framework nucleic acid-programmed aptamer-paclitaxel conjugates as targeted therapeutics for triple-negative breast cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Framework nucleic acid-programmed aptamer-paclitaxel conjugates as targeted therapeutics for triple-negative breast cancer.
7580,25488,40073943,10.1016/j.jconrel.2025.113624,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;lnp,"delivery candidate; matched derived terms: delivery, lnp; source title: A Mannosylated peptidyl lipid CManDA doped into cytidinyl/cationic lipids efficiently delivers siG12Ss to lung cancer in vivo.",C,high_candidate,curator_verified,accept,derived_annotations_only,A Mannosylated peptidyl lipid CManDA doped into cytidinyl/cationic lipids efficiently delivers siG12Ss to lung cancer in vivo.
7581,25489,40073943,10.1016/j.jconrel.2025.113624,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Mannosylated peptidyl lipid CManDA doped into cytidinyl/cationic lipids efficiently delivers siG12Ss to lung cancer in vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Mannosylated peptidyl lipid CManDA doped into cytidinyl/cationic lipids efficiently delivers siG12Ss to lung cancer in vivo.
7583,25511,40064874,10.1038/s41467-025-57488-0,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics.
7585,25515,40064331,10.1016/j.ahj.2025.03.003,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Design and rationale of the CORE-TIMI 72a and CORE2-TIMI 72b trials of olezarsen in patients with severe hypertriglyceridemia.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Design and rationale of the CORE-TIMI 72a and CORE2-TIMI 72b trials of olezarsen in patients with severe hypertriglyceridemia.
7588,25530,40059770,10.1080/22221751.2025.2477668,assay,ASO/siRNA,PubMed abstract sentence 2,screen;model,"assay candidate; matched derived terms: screen, model; source title: CpG oligodeoxynucleotides and pan-serotype inhibitors control neurotropic dengue infection in novel immune competent neonatal mouse model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CpG oligodeoxynucleotides and pan-serotype inhibitors control neurotropic dengue infection in novel immune competent neonatal mouse model.
7590,25532,40059770,10.1080/22221751.2025.2477668,benchmark,ASO/siRNA,PubMed abstract sentence 3,model;challenge,"benchmark candidate; matched derived terms: model, challenge; source title: CpG oligodeoxynucleotides and pan-serotype inhibitors control neurotropic dengue infection in novel immune competent neonatal mouse model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CpG oligodeoxynucleotides and pan-serotype inhibitors control neurotropic dengue infection in novel immune competent neonatal mouse model.
7591,25537,40059153,10.1186/s12943-025-02274-1,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Modulating lipid metabolism by nanoparticles (NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modulating lipid metabolism by nanoparticles (NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis.
7594,25552,40056883,10.1016/j.bioelechem.2025.108965,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: In-situ integrated Ce-MOF-808@CeO(2) as bifunctional matrix for sensitive electrochemical-aptasensing of tetracycline in shrimp.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In-situ integrated Ce-MOF-808@CeO(2) as bifunctional matrix for sensitive electrochemical-aptasensing of tetracycline in shrimp.
7598,25570,40051178,10.1002/advs.202409065,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Polyplex Nanomicelle-Mediated Pgc-1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Polyplex Nanomicelle-Mediated Pgc-1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice.
7602,25580,40049497,10.1016/j.ijbiomac.2025.141754,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: α(v)β(3) integrin aptamer functionalized pH-responsive lipid polymer hybrid nanoparticles for targeted co-delivery of paclitaxel and tamoxifen.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,α(v)β(3) integrin aptamer functionalized pH-responsive lipid polymer hybrid nanoparticles for targeted co-delivery of paclitaxel and tamoxifen.
7603,25581,40049497,10.1016/j.ijbiomac.2025.141754,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: α(v)β(3) integrin aptamer functionalized pH-responsive lipid polymer hybrid nanoparticles for targeted co-delivery of paclitaxel and tamoxifen.",B,high_candidate,curator_rejected,reject,derived_annotations_only,α(v)β(3) integrin aptamer functionalized pH-responsive lipid polymer hybrid nanoparticles for targeted co-delivery of paclitaxel and tamoxifen.
7604,25586,40048691,10.1200/JCO.24.00727,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Randomized, Open-Label, Phase III Study of Tilsotolimod in Combination With Ipilimumab Versus Ipilimumab Alone in Patients With Advanced Refractory Melanoma (ILLUMINATE-301).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Randomized, Open-Label, Phase III Study of Tilsotolimod in Combination With Ipilimumab Versus Ipilimumab Alone in Patients With Advanced Refractory Melanoma (ILLUMINATE-301)."
7605,25589,40048440,10.1371/journal.pone.0314581,assay,ASO/siRNA,PubMed abstract sentence 3,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems.
7607,25597,40045577,10.1016/j.ymthe.2025.02.047,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle;conjugated,"delivery candidate; matched derived terms: delivery, nanoparticle, conjugated; source title: Using aptamers for targeted delivery of RNA therapies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Using aptamers for targeted delivery of RNA therapies.
7609,25603,40043915,10.1016/j.jconrel.2025.113604,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: A nasally administrated reactive oxygen species-responsive carrier-free gene delivery nanosystem for Alzheimer's disease combination therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A nasally administrated reactive oxygen species-responsive carrier-free gene delivery nanosystem for Alzheimer's disease combination therapy.
7610,25604,40043915,10.1016/j.jconrel.2025.113604,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A nasally administrated reactive oxygen species-responsive carrier-free gene delivery nanosystem for Alzheimer's disease combination therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A nasally administrated reactive oxygen species-responsive carrier-free gene delivery nanosystem for Alzheimer's disease combination therapy.
7616,25624,40037707,10.1093/nar/gkaf144,chemistry,ASO,PubMed abstract sentence 3,chemical;modification;phosphorothioate;2'-o,"chemistry candidate; matched derived terms: chemical, modification, phosphorothioate, 2'-o; source title: Chemical evolution of ASO-like DNAzymes for effective and extended gene silencing in cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical evolution of ASO-like DNAzymes for effective and extended gene silencing in cells.
7619,25647,40033796,10.1021/acsbiomaterials.4c02184,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Construction of a Mirror-Image RNA Nanostructure for Enhanced Biostability and Drug Delivery Efficiency.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Construction of a Mirror-Image RNA Nanostructure for Enhanced Biostability and Drug Delivery Efficiency.
7620,25648,40033796,10.1021/acsbiomaterials.4c02184,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Construction of a Mirror-Image RNA Nanostructure for Enhanced Biostability and Drug Delivery Efficiency.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Construction of a Mirror-Image RNA Nanostructure for Enhanced Biostability and Drug Delivery Efficiency.
7634,25740,40006507,10.3390/pharmaceutics17020139,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Intestinal Probiotic Lysate Modified Bifunctional Nanoparticle for Efficient Colon Cancer Immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intestinal Probiotic Lysate Modified Bifunctional Nanoparticle for Efficient Colon Cancer Immunotherapy.
7641,25769,39998071,10.3390/toxins17020054,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage.
7645,25787,39993805,10.21873/cgp.20494,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Prostate Cancer: De-regulated Circular RNAs With Efficacy in Preclinical In Vivo Models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prostate Cancer: De-regulated Circular RNAs With Efficacy in Preclinical In Vivo Models.
7650,25806,39990216,10.7150/thno.102559,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Trehalose activates autophagy to alleviate cisplatin-induced chronic kidney injury by targeting the mTOR-dependent TFEB signaling pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Trehalose activates autophagy to alleviate cisplatin-induced chronic kidney injury by targeting the mTOR-dependent TFEB signaling pathway.
7656,25822,39988262,10.1016/j.ejps.2025.107050,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Local delivery of lipid-based nanoparticles containing microbial nucleic acid for osteoimmunomodulation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Local delivery of lipid-based nanoparticles containing microbial nucleic acid for osteoimmunomodulation.
7659,25837,39985217,10.1002/advs.202416265,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self-Sustaining Positive Feedback-Driven Drug Release Mechanisms.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self-Sustaining Positive Feedback-Driven Drug Release Mechanisms.
7672,25908,39960339,10.1002/advs.202410908,chemistry,ASO/siRNA,PubMed abstract sentence 5,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function.
7680,25940,39950625,10.1099/jmm.0.001972,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Viral vectors: design and delivery for small RNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Viral vectors: design and delivery for small RNA.
7682,25946,39950511,10.1002/smll.202409052,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: Reversing Photodynamic Therapy-Induced Tumor Metabolic Symbiosis and Immune Evasion Delivers a Two-Punch Attack on Tumors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Reversing Photodynamic Therapy-Induced Tumor Metabolic Symbiosis and Immune Evasion Delivers a Two-Punch Attack on Tumors.
7684,25958,39941845,10.3390/cancers17030479,assay,ASO/siRNA,PubMed abstract sentence 8,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Long-Term Survival of Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib in Real-World Clinical Practice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Long-Term Survival of Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib in Real-World Clinical Practice.
7691,25991,39931565,10.3389/fmolb.2025.1460565,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Uptake of iron from ferrous fumarate can be mediated by clathrin-dependent endocytosis in Hutu-80 cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Uptake of iron from ferrous fumarate can be mediated by clathrin-dependent endocytosis in Hutu-80 cells.
7695,26007,39928593,10.1097/HEP.0000000000001256,assay,ASO/siRNA,PubMed abstract sentence 9,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Aptamer-directed, nanovesicle-mediated targeting of undruggable molecules in preclinical cholangiocarcinoma models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Aptamer-directed, nanovesicle-mediated targeting of undruggable molecules in preclinical cholangiocarcinoma models."
7712,26058,39911386,10.3389/fimmu.2025.1540192,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Applications of cell penetrating peptide-based drug delivery system in immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Applications of cell penetrating peptide-based drug delivery system in immunotherapy.
7713,26059,39911386,10.3389/fimmu.2025.1540192,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Applications of cell penetrating peptide-based drug delivery system in immunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Applications of cell penetrating peptide-based drug delivery system in immunotherapy.
7715,26069,39910288,10.1038/s12276-025-01407-2,assay,ASO/siRNA,PubMed abstract sentence 10,model;trial,"assay candidate; matched derived terms: model, trial; source title: Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron.
7718,26082,39906733,10.1016/j.omtn.2024.102427,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted allele-specific FGFR2 knockdown via human recombinant ferritin nanoparticles for personalized treatment of Crouzon syndrome.
7725,26113,39894982,10.1021/acsami.4c17384,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted and Synergistic Codelivery of Chemotherapeutic and Nucleic Acid Drugs by Liposome-Coated MPDA Nanoparticles for Advanced Prostate Cancer Treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted and Synergistic Codelivery of Chemotherapeutic and Nucleic Acid Drugs by Liposome-Coated MPDA Nanoparticles for Advanced Prostate Cancer Treatment.
7726,26118,39893759,10.1016/j.bmc.2025.118080,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Janus dendritic ionizable lipids with fine designed headgroup and tails to improve mRNA delivery efficiency.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Janus dendritic ionizable lipids with fine designed headgroup and tails to improve mRNA delivery efficiency.
7727,26119,39893759,10.1016/j.bmc.2025.118080,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Janus dendritic ionizable lipids with fine designed headgroup and tails to improve mRNA delivery efficiency.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Janus dendritic ionizable lipids with fine designed headgroup and tails to improve mRNA delivery efficiency.
7729,26143,39884591,10.1016/j.ijpharm.2025.125294,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nucleolin-targeted silicon-based nanoparticles for enhanced chemo-sonodynamic therapy of diffuse large B-cell lymphoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nucleolin-targeted silicon-based nanoparticles for enhanced chemo-sonodynamic therapy of diffuse large B-cell lymphoma.
7740,26194,39862582,10.1016/j.jinorgbio.2025.112831,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Large-capacity DNA vectors based on rolling circle amplification with multivalent aptamers delivery copper sulfide for the synergistic treatment of Cancer through chemo/Photothermal/Chemodynamic therapy in vitro.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Large-capacity DNA vectors based on rolling circle amplification with multivalent aptamers delivery copper sulfide for the synergistic treatment of Cancer through chemo/Photothermal/Chemodynamic therapy in vitro.
7744,26226,39843740,10.1038/s41586-024-08462-1,assay,ASO,PubMed abstract sentence 3,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Rapid and scalable personalized ASO screening in patient-derived organoids.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rapid and scalable personalized ASO screening in patient-derived organoids.
7749,26247,39834294,10.1021/acsnano.4c11858,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics.
7753,26263,39827759,10.1016/j.jcis.2025.01.107,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticles (NPs)-mediated silencing of GSTP1 expression to reverse chemoresistance for effective breast cancer therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticles (NPs)-mediated silencing of GSTP1 expression to reverse chemoresistance for effective breast cancer therapy.
7772,26350,39793183,10.1016/j.jmr.2024.107827,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: (1)H-(19)F cross-polarization magic angle spinning dynamic nuclear polarization NMR investigation of advanced pharmaceutical formulations.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,(1)H-(19)F cross-polarization magic angle spinning dynamic nuclear polarization NMR investigation of advanced pharmaceutical formulations.
7773,26353,39792811,10.1002/advs.202409729,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA."
7776,26372,39777536,10.1007/s00210-024-03751-y,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Evaluation of anticancer efficacy of survivin si-RNA functionalized combined drug-loaded mesoporous silica nanoparticles in a lung cancer mouse model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of anticancer efficacy of survivin si-RNA functionalized combined drug-loaded mesoporous silica nanoparticles in a lung cancer mouse model.
7781,26393,39764891,10.1016/j.molimm.2024.12.008,assay,ASO/siRNA,PubMed abstract sentence 7,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: Development of a ferroptosis-related gene prognostic model and molecular subgroups characterization in sepsis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of a ferroptosis-related gene prognostic model and molecular subgroups characterization in sepsis.
7782,26394,39764891,10.1016/j.molimm.2024.12.008,benchmark,ASO/siRNA,PubMed abstract sentence 2,database;dataset,"benchmark candidate; matched derived terms: database, dataset; source title: Development of a ferroptosis-related gene prognostic model and molecular subgroups characterization in sepsis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of a ferroptosis-related gene prognostic model and molecular subgroups characterization in sepsis.
7784,26406,39759873,10.1016/j.omtn.2024.102404,chemistry,ASO/siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Discovery and characterization of stereodefined PMO-gapmers targeting tau.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Discovery and characterization of stereodefined PMO-gapmers targeting tau.
7790,26434,39751928,10.1007/s11064-024-04302-w,toxicity,ASO,PubMed abstract sentence 7,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Breaking Barriers in Huntington's Disease Therapy: Focused Ultrasound for Targeted Drug Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Breaking Barriers in Huntington's Disease Therapy: Focused Ultrasound for Targeted Drug Delivery.
7796,26456,39740143,10.1021/jacs.4c16829,chemistry,ASO/siRNA,PubMed abstract sentence 5,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Photochemically Triggered, Transient, and Oscillatory Transcription Machineries Guide Temporal Modulation of Fibrinogenesis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Photochemically Triggered, Transient, and Oscillatory Transcription Machineries Guide Temporal Modulation of Fibrinogenesis."
7797,26463,39731455,10.1002/ijgo.16125,assay,ASO/siRNA,PubMed abstract sentence 4,screen;model,"assay candidate; matched derived terms: screen, model; source title: Cost-effectiveness analysis of 9-valent human papillomavirus vaccine combined with screening for cervical cancer in Japan.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cost-effectiveness analysis of 9-valent human papillomavirus vaccine combined with screening for cervical cancer in Japan.
7807,26521,39674384,10.1016/j.ijpharm.2024.125049,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Unleashing the potential of natural protein based nanoparticles for the delivery of therapeutic nucleic Acid: A comprehensive review.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unleashing the potential of natural protein based nanoparticles for the delivery of therapeutic nucleic Acid: A comprehensive review.
7824,26610,39588591,10.1002/advs.202410632,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sequentially Activated Smart DNA Nanospheres for Photoimmunotherapy and Immune Checkpoint Blockade.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sequentially Activated Smart DNA Nanospheres for Photoimmunotherapy and Immune Checkpoint Blockade.
7825,26625,39571783,10.1016/j.canlet.2024.217324,assay,ASO/siRNA,PubMed abstract sentence 6,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Exploring bile acid transporters as key players in cancer development and treatment: Evidence from preclinical and clinical studies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exploring bile acid transporters as key players in cancer development and treatment: Evidence from preclinical and clinical studies.
7837,26679,39488156,10.1016/j.talanta.2024.127134,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Single gold nanowire-nanoparticles conjugated system: Fabrication and sensing application.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Single gold nanowire-nanoparticles conjugated system: Fabrication and sensing application.
7842,26702,39454415,10.1016/j.bioadv.2024.214081,delivery,ASO/siRNA,PubMed abstract sentence 9,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Synergistic pH-responsive MUC-1 aptamer-conjugated Ag/MSN Janus nanoparticles for targeted chemotherapy, photothermal therapy, and gene therapy in breast cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Synergistic pH-responsive MUC-1 aptamer-conjugated Ag/MSN Janus nanoparticles for targeted chemotherapy, photothermal therapy, and gene therapy in breast cancer."
7848,26728,39392510,10.1080/1061186X.2024.2416241,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Development of non-viral targeted RNA delivery vehicles - a key factor in success of therapeutic RNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of non-viral targeted RNA delivery vehicles - a key factor in success of therapeutic RNA.
7849,26729,39392510,10.1080/1061186X.2024.2416241,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of non-viral targeted RNA delivery vehicles - a key factor in success of therapeutic RNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of non-viral targeted RNA delivery vehicles - a key factor in success of therapeutic RNA.
7851,26737,39383211,10.1093/neuonc/noae210,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing.
7853,26749,39313647,10.1038/s41587-024-02393-y,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;modification;lna,"chemistry candidate; matched derived terms: chemical, modification, lna; source title: Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation.
7858,26770,39278297,10.1016/j.jep.2024.118820,assay,ASO,PubMed abstract sentence 1,model;trial,"assay candidate; matched derived terms: model, trial; source title: Qian Yang Yu Yin Granule prevents hypertensive cardiac remodeling by inhibiting NLRP3 inflammasome activation via Nrf2.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Qian Yang Yu Yin Granule prevents hypertensive cardiac remodeling by inhibiting NLRP3 inflammasome activation via Nrf2.
7865,26803,39225259,10.1056/NEJMoa2409368,toxicity,ASO/siRNA,PubMed abstract sentence 10,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk.
7873,26839,38803312,10.1002/smtd.202400278,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Tumor Microenvironment-Responsive Polymer-Based RNA Delivery Systems for Cancer Treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tumor Microenvironment-Responsive Polymer-Based RNA Delivery Systems for Cancer Treatment.
7879,26857,38648653,10.1002/adhm.202303815,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Covalent Polymer-RNA Conjugates for Potent Activation of the RIG-I Pathway.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Covalent Polymer-RNA Conjugates for Potent Activation of the RIG-I Pathway.
7888,26886,40125243,10.59566/isrnn.2024.0101016,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Targeted Delivery of Potent Chemical Drugs and RNAi to Drug-Resistant Breast Cancer Using RNA-Nanotechnology and RNA-Ligand Displaying Extracellular vesicles.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted Delivery of Potent Chemical Drugs and RNAi to Drug-Resistant Breast Cancer Using RNA-Nanotechnology and RNA-Ligand Displaying Extracellular vesicles.
7893,26913,39795992,10.3390/ijms26010134,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Probing the Effects of Chemical Modifications on Anticoagulant and Antiproliferative Activity of Thrombin Binding Aptamer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Probing the Effects of Chemical Modifications on Anticoagulant and Antiproliferative Activity of Thrombin Binding Aptamer.
7894,26916,39795918,10.3390/ijms26010059,chemistry,ASO/siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Exploring the Chemical Features and Biomedical Relevance of Cell-Penetrating Peptides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exploring the Chemical Features and Biomedical Relevance of Cell-Penetrating Peptides.
7897,26925,39771551,10.3390/pharmaceutics16121572,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanotechnology-Based Approaches for the Management of Diabetes Mellitus: An Innovative Solution to Long-Lasting Challenges in Antidiabetic Drug Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanotechnology-Based Approaches for the Management of Diabetes Mellitus: An Innovative Solution to Long-Lasting Challenges in Antidiabetic Drug Delivery.
7899,26933,39769486,10.3390/ijms252413724,delivery,ASO/siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Cell Membrane- and Extracellular Vesicle-Coated Chitosan Methacrylate-Tripolyphosphate Nanoparticles for RNA Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cell Membrane- and Extracellular Vesicle-Coated Chitosan Methacrylate-Tripolyphosphate Nanoparticles for RNA Delivery.
7903,26947,39759399,10.3389/fnagi.2024.1480332,assay,ASO/siRNA,PubMed abstract sentence 4,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: The study on cuproptosis in Alzheimer's disease based on the cuproptosis key gene FDX1.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The study on cuproptosis in Alzheimer's disease based on the cuproptosis key gene FDX1.
7911,26999,39696364,10.1186/s13045-024-01643-5,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: myCAF-derived exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,myCAF-derived exosomal PWAR6 accelerates CRC liver metastasis via altering glutamine availability and NK cell function in the tumor microenvironment.
7919,27043,39618878,10.31083/j.rcm2511393,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Lipoprotein (a): Underrecognized Risk with a Promising Future.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipoprotein (a): Underrecognized Risk with a Promising Future.
7923,27059,39598377,10.3390/ph17111465,assay,siRNA,PubMed abstract sentence 4,assay;phase,"assay candidate; matched derived terms: assay, phase; source title: RNAi Screen Identifies AXL Inhibition Combined with Cannabinoid WIN55212-2 as a Potential Strategy for Cancer Treatment.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi Screen Identifies AXL Inhibition Combined with Cannabinoid WIN55212-2 as a Potential Strategy for Cancer Treatment.
7926,27076,39588258,10.2147/IJN.S476546,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: SFRP1-Silencing GapmeR-Loaded Lipid-Polymer Hybrid Nanoparticles for Bone Regeneration in Osteoporosis: Effect of Dosing and Targeting Strategy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,SFRP1-Silencing GapmeR-Loaded Lipid-Polymer Hybrid Nanoparticles for Bone Regeneration in Osteoporosis: Effect of Dosing and Targeting Strategy.
7938,27136,39552122,10.1021/acsami.4c15185,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Modulation of Short-Term Delivery of Proteins from Hydrogels.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Modulation of Short-Term Delivery of Proteins from Hydrogels.
7941,27149,39535929,10.1021/acs.biomac.4c01355,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Alkylated RALA-Derived Peptides for Efficient Gene Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Alkylated RALA-Derived Peptides for Efficient Gene Delivery.
7950,27188,39514216,10.1021/acs.biomac.4c01128,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineering an Ultrasound-Responsive Glycopolymersome for Hepatocyte-Specific Gene Delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Engineering an Ultrasound-Responsive Glycopolymersome for Hepatocyte-Specific Gene Delivery.
7960,27226,39484963,10.1021/acs.molpharmaceut.4c00841,delivery,ASO/siRNA,PubMed abstract sentence 6,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Glatiramer Acetate Complexes CpG Oligodeoxynucleotides into Nanoparticles and Boosts Their TLR9-Driven Immunity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Glatiramer Acetate Complexes CpG Oligodeoxynucleotides into Nanoparticles and Boosts Their TLR9-Driven Immunity.
7963,27243,39477529,10.1261/rna.080273.124,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Development of bioconjugate-based delivery systems for nucleic acids.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of bioconjugate-based delivery systems for nucleic acids.
7969,27263,39469883,10.1080/17512433.2024.2423724,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: Messenger interference RNA therapies targeting apolipoprotein C-III and angiopoietin-like protein 3 for mixed hyperlipidemia: the future of plozasiran and zodasiran.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Messenger interference RNA therapies targeting apolipoprotein C-III and angiopoietin-like protein 3 for mixed hyperlipidemia: the future of plozasiran and zodasiran.
7980,27320,39426128,10.1016/j.ejmech.2024.116955,chemistry,ASO,PubMed abstract sentence 3,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Novel NTCP ligand dimeric bile acid conjugated with ASO reduce hepatitis B virus surface antigen in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel NTCP ligand dimeric bile acid conjugated with ASO reduce hepatitis B virus surface antigen in vivo.
7981,27321,39426128,10.1016/j.ejmech.2024.116955,delivery,ASO,PubMed abstract sentence 3,galnac;conjugated;uptake,"delivery candidate; matched derived terms: galnac, conjugated, uptake; source title: Novel NTCP ligand dimeric bile acid conjugated with ASO reduce hepatitis B virus surface antigen in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel NTCP ligand dimeric bile acid conjugated with ASO reduce hepatitis B virus surface antigen in vivo.
7983,27345,39402710,10.1021/acs.analchem.4c04607,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Saponin is Essential for the Isolation of Proteins and RNA from Biological Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Saponin is Essential for the Isolation of Proteins and RNA from Biological Nanoparticles.
7991,27387,39376088,10.1021/acs.bioconjchem.4c00376,chemistry,ASO/siRNA,PubMed abstract sentence 4,modified;conjugate,"chemistry candidate; matched derived terms: modified, conjugate; source title: Inhibitory Effects on RNA Binding and RNase H Induction Activity of Prodrug-Type Oligodeoxynucleotides Modified with a Galactosylated Self-Immolative Linker Cleavable by β-Galactosidase.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhibitory Effects on RNA Binding and RNase H Induction Activity of Prodrug-Type Oligodeoxynucleotides Modified with a Galactosylated Self-Immolative Linker Cleavable by β-Galactosidase.
7993,27391,39375971,10.1002/smll.202402802,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Optimized Fabrication of Dendritic Mesoporous Silica Nanoparticles as Efficient Delivery System for Cancer Immunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Optimized Fabrication of Dendritic Mesoporous Silica Nanoparticles as Efficient Delivery System for Cancer Immunotherapy.
8000,27412,39363565,10.1021/acsnano.4c08044,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Innovative Oral Nano/Gene Delivery System Based on Engineered Modified Saccharomyces cerevisiae for Colorectal Cancer Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Innovative Oral Nano/Gene Delivery System Based on Engineered Modified Saccharomyces cerevisiae for Colorectal Cancer Therapy.
8002,27422,39358248,10.1248/yakushi.24-00134,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: [Synthesis of Coumarin-oligonucleiotide Conjugates for Application in DNA-encoded Libraries].",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,[Synthesis of Coumarin-oligonucleiotide Conjugates for Application in DNA-encoded Libraries].
8007,27439,39352860,10.1681/ASN.0000000000000428,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: METTL3-Mediated N 6 -Methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,METTL3-Mediated N 6 -Methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis.
8010,27458,39339179,10.3390/pharmaceutics16091142,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid-Based Nanoparticles Fused with Natural Killer Cell Plasma Membrane Proteins for Triple-Negative Breast Cancer Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid-Based Nanoparticles Fused with Natural Killer Cell Plasma Membrane Proteins for Triple-Negative Breast Cancer Therapy.
8011,27461,39337674,10.3390/ijms251810188,assay,ASO/siRNA,PubMed abstract sentence 6,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: Components in SLPE Alleviate AD Model Nematodes by Up-Regulating Gene gst-5.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Components in SLPE Alleviate AD Model Nematodes by Up-Regulating Gene gst-5.
8016,27480,39332586,10.1016/j.canlet.2024.217265,assay,ASO/siRNA,PubMed abstract sentence 6,assay;model,"assay candidate; matched derived terms: assay, model; source title: Integration of transcriptomics, proteomics and loss-of-function screening reveals WEE1 as a target for combination with dasatinib against proneural glioblastoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Integration of transcriptomics, proteomics and loss-of-function screening reveals WEE1 as a target for combination with dasatinib against proneural glioblastoma."
8017,27483,39331729,10.1097/MOL.0000000000000954,assay,ASO/siRNA,PubMed abstract sentence 7,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: From clinical development to real-world outcomes with inclisiran.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,From clinical development to real-world outcomes with inclisiran.
8045,27613,39246205,10.1002/advs.202407619,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles.
8047,27625,39236265,10.1164/rccm.202402-0389CI,assay,ASO/siRNA,PubMed abstract sentence 9,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Lentiviral Gene Therapy for Cystic Fibrosis: A Promising Approach and First-in-Human Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lentiviral Gene Therapy for Cystic Fibrosis: A Promising Approach and First-in-Human Trial.
8048,27630,39233175,10.1016/j.ijbiomac.2024.135259,chemistry,ASO/siRNA,PubMed abstract sentence 2,modification;modified,"chemistry candidate; matched derived terms: modification, modified; source title: Fabrication of multifunctional hybrid pigment for color cosmetics based on chitosan-modified palygorskite and sappanwood extract.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Fabrication of multifunctional hybrid pigment for color cosmetics based on chitosan-modified palygorskite and sappanwood extract.
8050,27654,39217472,10.1093/nar/gkae729,chemistry,ASO/siRNA,PubMed abstract sentence 1,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Unlocking precision in aptamer engineering: a case study of the thrombin binding aptamer illustrates why modification size, quantity, and position matter.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Unlocking precision in aptamer engineering: a case study of the thrombin binding aptamer illustrates why modification size, quantity, and position matter."
8054,27668,39209454,10.1136/jitc-2024-008977,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Nanoparticles targeting immune checkpoint protein VISTA induce potent antitumor immunity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticles targeting immune checkpoint protein VISTA induce potent antitumor immunity.
8058,27682,39204314,10.3390/pharmaceutics16080969,delivery,ASO/siRNA,PubMed abstract sentence 13,delivery;nanoparticle;route,"delivery candidate; matched derived terms: delivery, nanoparticle, route; source title: The Role of Inhaled Chitosan-Based Nanoparticles in Lung Cancer Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Role of Inhaled Chitosan-Based Nanoparticles in Lung Cancer Therapy.
8061,27693,39201574,10.3390/ijms25168888,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nucleic Acid Armor: Fortifying RNA Therapeutics through Delivery and Targeting Innovations for Immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nucleic Acid Armor: Fortifying RNA Therapeutics through Delivery and Targeting Innovations for Immunotherapy.
8062,27694,39201574,10.3390/ijms25168888,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nucleic Acid Armor: Fortifying RNA Therapeutics through Delivery and Targeting Innovations for Immunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nucleic Acid Armor: Fortifying RNA Therapeutics through Delivery and Targeting Innovations for Immunotherapy.
8063,27699,39200025,10.3390/antibiotics13080725,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identifying Cell-Penetrating Peptides for Effectively Delivering Antimicrobial Molecules into Streptococcus suis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identifying Cell-Penetrating Peptides for Effectively Delivering Antimicrobial Molecules into Streptococcus suis.
8065,27707,39197450,10.1016/j.cell.2024.07.052,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals.
8077,27753,39178725,10.1016/j.copbio.2024.103182,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery approaches of immunomodulatory nucleic acids for cancer therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery approaches of immunomodulatory nucleic acids for cancer therapy.
8080,27770,39168564,10.1016/j.jacc.2024.05.058,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: The Off-Treatment Effects of Olpasiran on Lipoprotein(a) Lowering: OCEAN(a)-DOSE Extension Period Results.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Off-Treatment Effects of Olpasiran on Lipoprotein(a) Lowering: OCEAN(a)-DOSE Extension Period Results.
8082,27776,39164686,10.1186/s12929-024-01069-8,delivery,ASO/siRNA,PubMed abstract sentence 7,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment.
8083,27777,39164686,10.1186/s12929-024-01069-8,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment.
8089,27801,39151088,10.1021/acsnano.4c06313,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Charge Detection Mass Spectrometry Enables Molecular Characterization of Nucleic Acid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Charge Detection Mass Spectrometry Enables Molecular Characterization of Nucleic Acid Nanoparticles.
8091,27817,39138650,10.1007/s00415-024-12616-6,assay,ASO/siRNA,PubMed abstract sentence 1,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Switching from inotersen to eplontersen in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: analysis from NEURO-TTRansform.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Switching from inotersen to eplontersen in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: analysis from NEURO-TTRansform.
8094,27828,39136619,10.1021/acs.joc.4c01193,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Claisen Self-Condensation of Lactones in the Synthesis of Ionizable Lipids.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Claisen Self-Condensation of Lactones in the Synthesis of Ionizable Lipids.
8096,27846,39127174,10.1016/j.nano.2024.102778,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Robust aptamer-targeted CRISPR/Cas9 delivery using mesenchymal stem cell membrane -liposome hybrid: BIRC5 gene knockout against melanoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Robust aptamer-targeted CRISPR/Cas9 delivery using mesenchymal stem cell membrane -liposome hybrid: BIRC5 gene knockout against melanoma.
8103,27871,39113071,10.1186/s12943-024-02071-2,assay,ASO/siRNA,PubMed abstract sentence 4,screen;model,"assay candidate; matched derived terms: screen, model; source title: Essential gene screening identifies the bromodomain-containing protein BRPF1 as a new actionable target for endocrine therapy-resistant breast cancers.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Essential gene screening identifies the bromodomain-containing protein BRPF1 as a new actionable target for endocrine therapy-resistant breast cancers.
8104,27886,39106627,10.1016/j.ijbiomac.2024.134515,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: Construction of charge-reversible coordination-crosslinked spherical nucleic acids to deliver dual anti-cancer genes and ferroptosis payloads.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Construction of charge-reversible coordination-crosslinked spherical nucleic acids to deliver dual anti-cancer genes and ferroptosis payloads.
8108,27902,39101472,10.1093/eurjpc/zwae254,assay,ASO/siRNA,PubMed abstract sentence 1,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme.
8110,27912,39097193,10.1016/j.jconrel.2024.07.078,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp;route,"delivery candidate; matched derived terms: nanoparticle, lnp, route; source title: Delivery vehicle and route of administration influences self-amplifying RNA biodistribution, expression kinetics, and reactogenicity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Delivery vehicle and route of administration influences self-amplifying RNA biodistribution, expression kinetics, and reactogenicity."
8112,27918,39096633,10.1016/j.jhazmat.2024.135379,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic;adverse;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, adverse, hepatotoxicity; source title: TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio).",B,high_candidate,curator_rejected,reject,derived_annotations_only,TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio).
8114,27926,39089913,10.1016/j.cllc.2024.07.002,assay,ASO/siRNA,PubMed abstract sentence 3,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Current Trial Report: A Multicenter Phase I/Ib study of Capmatinib Plus Trametinib in Patients With Metastatic Nonsmall Cell Lung Center Harboring MET Exon 14 Skipping Mutations and Other MET-Alterations.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Current Trial Report: A Multicenter Phase I/Ib study of Capmatinib Plus Trametinib in Patients With Metastatic Nonsmall Cell Lung Center Harboring MET Exon 14 Skipping Mutations and Other MET-Alterations.
8122,27958,39074647,10.1016/j.ijpharm.2024.124539,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery of 5-fluorouracil for cancer therapy using aptamer-based nonlinear hybridization chain reaction.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery of 5-fluorouracil for cancer therapy using aptamer-based nonlinear hybridization chain reaction.
8128,27982,39064589,10.3390/medicina60071160,assay,ASO/siRNA,PubMed abstract sentence 6,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Fatty Acid Synthase Promotes Hepatocellular Carcinoma Growth via S-Phase Kinase-Associated Protein 2/p27(KIP1) Regulation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Fatty Acid Synthase Promotes Hepatocellular Carcinoma Growth via S-Phase Kinase-Associated Protein 2/p27(KIP1) Regulation.
8130,27986,39064553,10.3390/medicina60071124,toxicity,ASO/siRNA,PubMed abstract sentence 10,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Efficacy of Alirocumab, Evolocumab, and Inclisiran in Patients with Hypercholesterolemia at Increased Cardiovascular Risk.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Efficacy of Alirocumab, Evolocumab, and Inclisiran in Patients with Hypercholesterolemia at Increased Cardiovascular Risk."
8132,27996,39056352,10.1039/d4nr02182g,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Advancements in rheumatoid arthritis therapy: a journey from conventional therapy to precision medicine via nanoparticles targeting immune cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advancements in rheumatoid arthritis therapy: a journey from conventional therapy to precision medicine via nanoparticles targeting immune cells.
8133,28005,39051560,10.1093/nar/gkae648,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: RNA encoded peptide barcodes enable efficient in vivo screening of RNA delivery systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA encoded peptide barcodes enable efficient in vivo screening of RNA delivery systems.
8147,28065,39027251,10.1016/j.apsb.2024.04.015,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders.
8161,28131,38988440,10.3892/ol.2024.14547,toxicity,ASO/siRNA,PubMed abstract sentence 2,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Predicting recurrence in intermediate‑ and high‑risk stage IB‑IIB cervical cancer treated with adjuvant cisplatin and paclitaxel chemotherapy post‑radical hysterectomy: The role of TBX2 expression.
8164,28138,38986965,10.1016/j.ijpharm.2024.124435,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Breaking barriers: Innovative approaches for skin delivery of RNA therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Breaking barriers: Innovative approaches for skin delivery of RNA therapeutics.
8179,28191,38965606,10.1186/s12951-024-02665-4,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted delivery of CEBPA-saRNA for the treatment of pancreatic ductal adenocarcinoma by transferrin receptor aptamer decorated tetrahedral framework nucleic acid.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted delivery of CEBPA-saRNA for the treatment of pancreatic ductal adenocarcinoma by transferrin receptor aptamer decorated tetrahedral framework nucleic acid.
8186,28214,38953843,10.1080/17435889.2024.2359356,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Optimizing lornoxicam-loaded poly(lactic-co-glycolic acid) and (polyethylene glycol) nanoparticles for transdermal delivery: ex vivo/in vivo inflammation evaluation.",C,high_candidate,curator_rejected,reject,derived_annotations_only,Optimizing lornoxicam-loaded poly(lactic-co-glycolic acid) and (polyethylene glycol) nanoparticles for transdermal delivery: ex vivo/in vivo inflammation evaluation.
8187,28215,38953843,10.1080/17435889.2024.2359356,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Optimizing lornoxicam-loaded poly(lactic-co-glycolic acid) and (polyethylene glycol) nanoparticles for transdermal delivery: ex vivo/in vivo inflammation evaluation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Optimizing lornoxicam-loaded poly(lactic-co-glycolic acid) and (polyethylene glycol) nanoparticles for transdermal delivery: ex vivo/in vivo inflammation evaluation.
8195,28287,38919398,10.1515/mr-2023-0069,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: DNA-based nanostructures for RNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,DNA-based nanostructures for RNA delivery.
8198,28300,38910563,10.1161/CIRCULATIONAHA.123.066577,assay,ASO/siRNA,PubMed abstract sentence 11,model;trial,"assay candidate; matched derived terms: model, trial; source title: Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation.
8200,28306,38909703,10.1016/j.jconrel.2024.06.051,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Ionizable nanoemulsions for RNA delivery into the central nervous system - importance of diffusivity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ionizable nanoemulsions for RNA delivery into the central nervous system - importance of diffusivity.
8205,28319,38904251,10.1161/JAHA.123.033544,assay,ASO/siRNA,PubMed abstract sentence 2,assay;trial,"assay candidate; matched derived terms: assay, trial; source title: Aptamer Proteomics for Biomarker Discovery in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Proteomic Substudy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer Proteomics for Biomarker Discovery in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Proteomic Substudy.
8213,28369,38878838,10.1016/j.ijpharm.2024.124340,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Camptothecin-loaded mesoporous silica nanoparticles functionalized with CpG oligodeoxynucleotide as a new approach for skin cancer treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Camptothecin-loaded mesoporous silica nanoparticles functionalized with CpG oligodeoxynucleotide as a new approach for skin cancer treatment.
8232,28488,38804735,10.1080/17460441.2024.2360415,assay,ASO/siRNA,PubMed abstract sentence 6,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Inclisiran: the preclinical discovery and development of a novel therapy for the treatment of atherosclerosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inclisiran: the preclinical discovery and development of a novel therapy for the treatment of atherosclerosis.
8233,28493,38803628,10.1016/j.lanepe.2024.100853,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Effectiveness of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in weight management services (STRIVE study): a multicentre, open-label, parallel-group, randomized controlled trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Effectiveness of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in weight management services (STRIVE study): a multicentre, open-label, parallel-group, randomized controlled trial."
8237,28507,38797356,10.1016/j.mito.2024.101906,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle;conjugated,"delivery candidate; matched derived terms: delivery, nanoparticle, conjugated; source title: Cell-penetrating peptides with nanoparticles hybrid delivery vectors and their uptake pathways.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cell-penetrating peptides with nanoparticles hybrid delivery vectors and their uptake pathways.
8240,28514,38796564,10.1007/s40121-024-00980-9,assay,ASO/siRNA,PubMed abstract sentence 4,model;phase,"assay candidate; matched derived terms: model, phase; source title: Population Pharmacokinetics of Bepirovirsen in Healthy Participants and Participants with Chronic Hepatitis B Virus Infection: Results from Phase 1, 2a, and 2b Studies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Population Pharmacokinetics of Bepirovirsen in Healthy Participants and Participants with Chronic Hepatitis B Virus Infection: Results from Phase 1, 2a, and 2b Studies."
8249,28601,38757725,10.1111/dom.15650,assay,ASO/siRNA,PubMed abstract sentence 1,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Inclisiran in individuals with diabetes or obesity: Post hoc pooled analyses of the ORION-9, ORION-10 and ORION-11 Phase 3 randomized trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Inclisiran in individuals with diabetes or obesity: Post hoc pooled analyses of the ORION-9, ORION-10 and ORION-11 Phase 3 randomized trials."
8250,28610,38753448,10.1093/cvr/cvae109,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Inclisiran administration potently and durably lowers LDL-C over an extended-term follow-up: the ORION-8 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inclisiran administration potently and durably lowers LDL-C over an extended-term follow-up: the ORION-8 trial.
8253,28627,38744360,10.1016/j.ijbiomac.2024.132240,assay,ASO/siRNA,PubMed abstract sentence 6,screen;model,"assay candidate; matched derived terms: screen, model; source title: Development and optimization of a DNA aptamer to delay β-bungarotoxin-induced lethality in a rodent model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development and optimization of a DNA aptamer to delay β-bungarotoxin-induced lethality in a rodent model.
8258,28646,38741123,10.1186/s12951-024-02505-5,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN.
8267,28711,38697280,10.1016/j.lfs.2024.122680,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;phosphorothioate,"chemistry candidate; matched derived terms: chemical, phosphorothioate; source title: H-ras-targeted genetic therapy remarkably surpassed docetaxel treatment in inhibiting chemically induced hepatic tumors in rats.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,H-ras-targeted genetic therapy remarkably surpassed docetaxel treatment in inhibiting chemically induced hepatic tumors in rats.
8274,28746,38681207,10.2147/DDDT.S447780,assay,ASO/siRNA,PubMed abstract sentence 6,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models.
8284,28786,38668481,10.3390/toxics12040258,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Natural Pyrethrin-Induced Oxidative Damage in Human Liver Cells through Nrf-2 Signaling Pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Natural Pyrethrin-Induced Oxidative Damage in Human Liver Cells through Nrf-2 Signaling Pathway.
8292,28828,38651918,10.1021/acsabm.4c00206,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Codelivery of CPT and siPHB1 with GSH/ROS Dual-Responsive Hybrid Nanoparticles Based on a [12]aneN(3)-Derived Lipid for Synergistic Lung Cancer Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Codelivery of CPT and siPHB1 with GSH/ROS Dual-Responsive Hybrid Nanoparticles Based on a [12]aneN(3)-Derived Lipid for Synergistic Lung Cancer Therapy.
8297,28851,38636395,10.1016/j.biopha.2024.116603,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis.
8302,28862,38631259,10.1016/j.tranon.2024.101961,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma.
8307,28887,38614225,10.1016/j.exger.2024.112415,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Lymphocyte antigen 96: A new potential biomarker and immune target in Parkinson's disease.
8308,28892,38612794,10.3390/ijms25073984,assay,ASO/siRNA,PubMed abstract sentence 8,screen;model,"assay candidate; matched derived terms: screen, model; source title: Spinocerebellar Ataxia Type 3 Pathophysiology-Implications for Translational Research and Clinical Studies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Spinocerebellar Ataxia Type 3 Pathophysiology-Implications for Translational Research and Clinical Studies.
8311,28905,38605811,10.1016/j.omtm.2024.101242,toxicity,siRNA,PubMed abstract sentence 2,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Subretinal AAV delivery of RNAi-therapeutics targeting VEGFA reduces choroidal neovascularization in a large animal model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Subretinal AAV delivery of RNAi-therapeutics targeting VEGFA reduces choroidal neovascularization in a large animal model.
8312,28906,38605811,10.1016/j.omtm.2024.101242,benchmark,siRNA,PubMed abstract sentence 8,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Subretinal AAV delivery of RNAi-therapeutics targeting VEGFA reduces choroidal neovascularization in a large animal model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Subretinal AAV delivery of RNAi-therapeutics targeting VEGFA reduces choroidal neovascularization in a large animal model.
8315,28931,38589751,10.1208/s12249-024-02793-y,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Revolutionizing the Treatment of Idiopathic Pulmonary Fibrosis: From Conventional Therapies to Advanced Drug Delivery Systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Revolutionizing the Treatment of Idiopathic Pulmonary Fibrosis: From Conventional Therapies to Advanced Drug Delivery Systems.
8317,28943,38587249,10.1056/NEJMoa2402309,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk.
8318,28944,38587249,10.1056/NEJMoa2402309,toxicity,ASO/siRNA,PubMed abstract sentence 11,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk.
8326,28972,38577537,10.4254/wjh.v16.i3.331,assay,ASO/siRNA,PubMed abstract sentence 6,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents.
8327,28979,38574952,10.1016/j.addr.2024.115302,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics.
8332,29000,38564997,10.1016/j.bioadv.2024.213833,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: AS1411 aptamer/RGD dual functionalized theranostic chitosan-PLGA nanoparticles for brain cancer treatment and imaging.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,AS1411 aptamer/RGD dual functionalized theranostic chitosan-PLGA nanoparticles for brain cancer treatment and imaging.
8342,29038,38548524,10.1016/j.jfma.2024.03.008,assay,siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Patisiran, an RNAi therapeutic for hereditary transthyretin-mediated amyloidosis: Sub-analysis in Taiwanese patients from the APOLLO study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Patisiran, an RNAi therapeutic for hereditary transthyretin-mediated amyloidosis: Sub-analysis in Taiwanese patients from the APOLLO study."
8348,29056,38543241,10.3390/pharmaceutics16030347,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: State-of-the-Art Review on Inhalable Lipid and Polymer Nanocarriers: Design and Development Perspectives.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,State-of-the-Art Review on Inhalable Lipid and Polymer Nanocarriers: Design and Development Perspectives.
8353,29075,38532439,10.1186/s13046-024-03014-x,delivery,ASO/siRNA,PubMed abstract sentence 8,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Bispecific aptamer-decorated and light-triggered nanoparticles targeting tumor and stromal cells in breast cancer derived organoids: implications for precision phototherapies.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Bispecific aptamer-decorated and light-triggered nanoparticles targeting tumor and stromal cells in breast cancer derived organoids: implications for precision phototherapies.
8354,29084,38522000,10.1002/psp4.13129,assay,ASO/siRNA,PubMed abstract sentence 11,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Model-based meta-analysis to quantify the effects of short interfering RNA therapeutics on hepatitis B surface antigen turnover in hepatitis B-infected mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Model-based meta-analysis to quantify the effects of short interfering RNA therapeutics on hepatitis B surface antigen turnover in hepatitis B-infected mice.
8360,29104,38507955,10.1016/j.biopha.2024.116465,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Smart co-delivery of plasmid DNA and doxorubicin using MCM-chitosan-PEG polymerization functionalized with MUC-1 aptamer against breast cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Smart co-delivery of plasmid DNA and doxorubicin using MCM-chitosan-PEG polymerization functionalized with MUC-1 aptamer against breast cancer.
8370,29164,38465204,10.2147/IJN.S446224,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Extracellular Vesicles: A New Star for Gene Drug Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Extracellular Vesicles: A New Star for Gene Drug Delivery.
8371,29173,38462363,10.3760/cma.j.cn112137-20231204-01281,assay,ASO/siRNA,PubMed abstract sentence 3,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: [Analysis of transfusion effect of different platelet matching schemes in patients with platelet transfusion refractoriness].",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,[Analysis of transfusion effect of different platelet matching schemes in patients with platelet transfusion refractoriness].
8373,29177,38459198,10.1038/s44320-024-00024-x,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.
8375,29185,38458739,10.1016/bs.pmbts.2024.01.001,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Advances in the polymeric nanoparticulate delivery systems for RNA therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in the polymeric nanoparticulate delivery systems for RNA therapeutics.
8388,29244,38445578,10.1021/acsnano.3c10732,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoengineered Polymeric RNA Nanoparticles for Controlled Biodistribution and Efficient Targeted Cancer Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoengineered Polymeric RNA Nanoparticles for Controlled Biodistribution and Efficient Targeted Cancer Therapy.
8390,29258,38437569,10.1073/pnas.2307798120,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Recent advances in nanoparticulate RNA delivery systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent advances in nanoparticulate RNA delivery systems.
8393,29265,38433928,10.1016/j.isci.2024.109191,assay,ASO/siRNA,PubMed abstract sentence 1,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Simple virus-free mouse models of COVID-19 pathologies and oral therapeutic intervention.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Simple virus-free mouse models of COVID-19 pathologies and oral therapeutic intervention.
8399,29307,38404181,10.1039/d3ay02002a,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: A 2D carbon nitride-based electrochemical aptasensor with reverse amplification for highly sensitive detection of okadaic acid in shellfish.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A 2D carbon nitride-based electrochemical aptasensor with reverse amplification for highly sensitive detection of okadaic acid in shellfish.
8405,29325,38399344,10.3390/pharmaceutics16020288,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Carbon-Based Nanostructures as Emerging Materials for Gene Delivery Applications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Carbon-Based Nanostructures as Emerging Materials for Gene Delivery Applications.
8409,29349,38394362,10.1021/acs.joc.3c02506,chemistry,ASO/siRNA,PubMed abstract sentence 8,modification;modified,"chemistry candidate; matched derived terms: modification, modified; source title: 4'-C-Acetamidomethyl-2'-O-methoxyethyl Nucleic Acid Modifications Improve Thermal Stability, Nuclease Resistance, Potency, and hAgo2 Binding of Small Interfering RNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"4'-C-Acetamidomethyl-2'-O-methoxyethyl Nucleic Acid Modifications Improve Thermal Stability, Nuclease Resistance, Potency, and hAgo2 Binding of Small Interfering RNAs."
8410,29356,38389096,10.1186/s13395-024-00335-5,assay,ASO/siRNA,PubMed abstract sentence 8,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle."
8411,29357,38389096,10.1186/s13395-024-00335-5,benchmark,ASO/siRNA,PubMed abstract sentence 8,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A knock down strategy for rapid, generic, and versatile modelling of muscular dystrophies in 3D-tissue-engineered-skeletal muscle."
8417,29379,38383972,,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Non-viral delivery of nucleic acid for treatment of rare diseases of the muscle.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Non-viral delivery of nucleic acid for treatment of rare diseases of the muscle.
8418,29386,38380796,10.1002/jgm.3672,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Trends in the synthetic polymer delivery of RNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Trends in the synthetic polymer delivery of RNA.
8423,29413,38370696,10.1101/2024.02.08.576722,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals.
8426,29422,38366937,10.1080/13543784.2024.2320700,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;trial,"assay candidate; matched derived terms: preclinical, trial; source title: Kallikrein inhibitors for angioedema: the progress of preclinical and early phase studies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Kallikrein inhibitors for angioedema: the progress of preclinical and early phase studies.
8431,29463,38358893,10.1016/j.xhgg.2024.100274,assay,ASO/siRNA,PubMed abstract sentence 7,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Clinical, immunohistochemical, and genetic characterization of splice-altering biallelic DES variants: Therapeutic implications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Clinical, immunohistochemical, and genetic characterization of splice-altering biallelic DES variants: Therapeutic implications."
8434,29470,38355725,10.1038/s41419-024-06535-7,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors.
8437,29481,38353513,10.1099/jmm.0.001807,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate morpholino oligomers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate morpholino oligomers.
8440,29488,38352376,10.1101/2024.01.31.578314,assay,siRNA,PubMed abstract sentence 2,model;trial,"assay candidate; matched derived terms: model, trial; source title: AAV-based delivery of RNAi targeting Ataxin-2 improves survival, strength, and pathology in mouse models of rapidly and slowly progressive sporadic ALS.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"AAV-based delivery of RNAi targeting Ataxin-2 improves survival, strength, and pathology in mouse models of rapidly and slowly progressive sporadic ALS."
8447,29509,38346399,10.1021/acsnano.3c09027,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids.",B,high_candidate,curator_rejected,reject,derived_annotations_only,An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids.
8453,29525,38342338,10.1016/j.xphs.2024.02.005,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Improving Chemotherapy Effectiveness: Utilizing CuS Nanoparticles Coated with AS1411 Aptamer and Chitosan for Targeted Delivery of Doxorubicin to Cancerous Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Improving Chemotherapy Effectiveness: Utilizing CuS Nanoparticles Coated with AS1411 Aptamer and Chitosan for Targeted Delivery of Doxorubicin to Cancerous Cells.
8454,29526,38342338,10.1016/j.xphs.2024.02.005,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Improving Chemotherapy Effectiveness: Utilizing CuS Nanoparticles Coated with AS1411 Aptamer and Chitosan for Targeted Delivery of Doxorubicin to Cancerous Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Improving Chemotherapy Effectiveness: Utilizing CuS Nanoparticles Coated with AS1411 Aptamer and Chitosan for Targeted Delivery of Doxorubicin to Cancerous Cells.
8457,29539,38338746,10.3390/ijms25031469,assay,ASO/siRNA,PubMed abstract sentence 7,preclinical;phase;trial,"assay candidate; matched derived terms: preclinical, phase, trial; source title: Trials and Tribulations of MicroRNA Therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Trials and Tribulations of MicroRNA Therapeutics.
8468,29584,38311162,10.1016/j.cbi.2024.110874,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Layered double hydroxides (LDHs) as efficient and safe carriers for miRNA inhibitors: In vitro and in vivo assessment of biocompatibility.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Layered double hydroxides (LDHs) as efficient and safe carriers for miRNA inhibitors: In vitro and in vivo assessment of biocompatibility.
8478,29638,38284616,10.1021/acs.chemrev.3c00611,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Chemically Modified Platforms for Better RNA Therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemically Modified Platforms for Better RNA Therapeutics.
8492,29738,38215360,10.1002/adhm.202303593,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment.
8508,29812,38161196,10.1007/s13346-023-01495-5,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeted co-delivery of FOXM1 aptamer and DOX by nucleolin aptamer-functionalized pH-responsive biocompatible nanodelivery system to enhance therapeutic efficacy against breast cancer: in vitro and in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted co-delivery of FOXM1 aptamer and DOX by nucleolin aptamer-functionalized pH-responsive biocompatible nanodelivery system to enhance therapeutic efficacy against breast cancer: in vitro and in vivo.
8509,29813,38161196,10.1007/s13346-023-01495-5,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted co-delivery of FOXM1 aptamer and DOX by nucleolin aptamer-functionalized pH-responsive biocompatible nanodelivery system to enhance therapeutic efficacy against breast cancer: in vitro and in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted co-delivery of FOXM1 aptamer and DOX by nucleolin aptamer-functionalized pH-responsive biocompatible nanodelivery system to enhance therapeutic efficacy against breast cancer: in vitro and in vivo.
8511,29823,38145340,10.1002/smll.202306134,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Non-Viral RNA Delivery During Pregnancy: Opportunities and Challenges.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Non-Viral RNA Delivery During Pregnancy: Opportunities and Challenges.
8512,29826,38142864,10.1016/j.jaip.2023.12.025,assay,ASO/siRNA,PubMed abstract sentence 7,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Clinical Progress in Hepatic Targeting for Novel Prophylactic Therapies in Hereditary Angioedema.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clinical Progress in Hepatic Targeting for Novel Prophylactic Therapies in Hereditary Angioedema.
8513,29829,38141196,10.2174/0115701611267835231210054909,toxicity,ASO/siRNA,PubMed abstract sentence 6,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Lipoprotein (a) as a Biomarker for Cardiovascular Diseases and Potential New Therapies to Mitigate Risk.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipoprotein (a) as a Biomarker for Cardiovascular Diseases and Potential New Therapies to Mitigate Risk.
8514,29832,38141015,10.1021/acsami.3c14714,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Development of Polymer-Lipid Hybrid Nanoparticles for Large-Sized Plasmid DNA Transfection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of Polymer-Lipid Hybrid Nanoparticles for Large-Sized Plasmid DNA Transfection.
8515,29835,38128829,10.1016/j.slasd.2023.12.009,assay,ASO/siRNA,PubMed abstract sentence 7,assay;screen;model,"assay candidate; matched derived terms: assay, screen, model; source title: Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations.
8516,29838,38127215,10.1245/s10434-023-14766-9,assay,ASO/siRNA,PubMed abstract sentence 1,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Adjuvant Trastuzumab Emtansine Versus Paclitaxel and Trastuzumab in Stage I HER2-Positive Breast Cancer: The ATEMPT Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Adjuvant Trastuzumab Emtansine Versus Paclitaxel and Trastuzumab in Stage I HER2-Positive Breast Cancer: The ATEMPT Trial.
8532,29898,38072781,10.1002/smll.202308857,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Single-Step Functionalization Strategy of Graphene Microtransistor Array with Chemically Modified Aptamers for Biosensing Applications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Single-Step Functionalization Strategy of Graphene Microtransistor Array with Chemically Modified Aptamers for Biosensing Applications.
8535,29905,38065244,10.1016/j.addr.2023.115147,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Emerging delivery approaches for targeted pulmonary fibrosis treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Emerging delivery approaches for targeted pulmonary fibrosis treatment.
8536,29916,38048786,10.1016/S0140-6736(23)01724-5,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge): a multinational, randomised, double-blind, placebo-controlled, phase 3 trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge): a multinational, randomised, double-blind, placebo-controlled, phase 3 trial."
8537,29917,38048786,10.1016/S0140-6736(23)01724-5,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge): a multinational, randomised, double-blind, placebo-controlled, phase 3 trial.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge): a multinational, randomised, double-blind, placebo-controlled, phase 3 trial."
8539,29921,38047368,10.1039/d3bm01089a,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Milk exosomes anchored with hydrophilic and zwitterionic motifs enhance mucus permeability for applications in oral gene delivery.
8544,29940,38033325,10.1093/nar/gkad1125,chemistry,ASO/siRNA,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo."
8545,29941,38033325,10.1093/nar/gkad1125,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo."
8549,29963,37991539,10.1007/s00210-023-02830-w,delivery,ASO/siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease.
8554,29984,37951519,10.1016/j.actbio.2023.10.038,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Engineering a biomimetic system for hepatocyte-specific RNAi treatment of non-alcoholic fatty liver disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Engineering a biomimetic system for hepatocyte-specific RNAi treatment of non-alcoholic fatty liver disease.
8565,30051,37792475,10.1002/adma.202303266,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Physiological Barriers and Strategies of Lipid-Based Nanoparticles for Nucleic Acid Drug Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Physiological Barriers and Strategies of Lipid-Based Nanoparticles for Nucleic Acid Drug Delivery.
8575,30115,38939004,10.1016/j.jacadv.2023.100407,toxicity,ASO/siRNA,PubMed abstract sentence 9,risk;renal,"toxicity candidate; matched derived terms: risk, renal; source title: Arterial Switch for Transposition of the Great Arteries: Treatment Timing, Late Outcomes, and Risk Factors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Arterial Switch for Transposition of the Great Arteries: Treatment Timing, Late Outcomes, and Risk Factors."
8578,30124,38320508,10.1056/EVIDe2300282,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Randomized Phase I Trials - One Size Fits All?",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Randomized Phase I Trials - One Size Fits All?
8579,30129,38283347,10.3389/fimmu.2023.1340755,assay,ASO/siRNA,PubMed abstract sentence 8,assay;preclinical;phase,"assay candidate; matched derived terms: assay, preclinical, phase; source title: Trypanosoma cruzi antigen detection in blood to assess treatment efficacy and cure in mice models of Chagas disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Trypanosoma cruzi antigen detection in blood to assess treatment efficacy and cure in mice models of Chagas disease.
8590,30172,38162739,10.1021/acsomega.3c07618,chemistry,ASO/siRNA,PubMed abstract sentence 2,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Evaluation of Chemically Modified Nucleic Acid Analogues for Splice Switching Application.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of Chemically Modified Nucleic Acid Analogues for Splice Switching Application.
8591,30179,38145112,10.1177/17588359231216089,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic;adverse;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, adverse, hepatotoxicity; source title: Chinese multidisciplinary expert consensus on the management of adverse drug reactions associated with savolitinib.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Chinese multidisciplinary expert consensus on the management of adverse drug reactions associated with savolitinib.
8597,30199,38130998,10.3748/wjg.v29.i45.5974,assay,ASO/siRNA,PubMed abstract sentence 14,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Thioridazine reverses trastuzumab resistance in gastric cancer by inhibiting S-phase kinase associated protein 2-mediated aerobic glycolysis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Thioridazine reverses trastuzumab resistance in gastric cancer by inhibiting S-phase kinase associated protein 2-mediated aerobic glycolysis.
8601,30211,38105200,10.1134/S0006297923110111,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Cell-Penetrating Peptides as Vehicles for Delivery of Therapeutic Nucleic Acids. Mechanisms and Application in Medicine.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cell-Penetrating Peptides as Vehicles for Delivery of Therapeutic Nucleic Acids. Mechanisms and Application in Medicine.
8605,30223,38092998,10.1186/s43556-023-00160-0,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Delivery of nucleic acids using nanomaterials.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of nucleic acids using nanomaterials.
8608,30232,38089093,10.1021/acsmaterialsau.3c00029,benchmark,ASO/siRNA,PubMed abstract sentence 9,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Engineered In Vitro Tumor Model Recapitulates Molecular Signatures of Invasion in Glioblastoma.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineered In Vitro Tumor Model Recapitulates Molecular Signatures of Invasion in Glioblastoma.
8610,30242,38069409,10.3390/ijms242317086,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: PSPC1 Inhibition Synergizes with Poly(ADP-ribose) Polymerase Inhibitors in a Preclinical Model of BRCA-Mutated Breast/Ovarian Cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,PSPC1 Inhibition Synergizes with Poly(ADP-ribose) Polymerase Inhibitors in a Preclinical Model of BRCA-Mutated Breast/Ovarian Cancer.
8617,30275,38016401,10.1016/j.atherosclerosis.2023.117354,assay,ASO/siRNA,PubMed abstract sentence 2,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Inclisiran in patients with prior myocardial infarction: A post hoc pooled analysis of the ORION-10 and ORION-11 Phase 3 randomised trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inclisiran in patients with prior myocardial infarction: A post hoc pooled analysis of the ORION-10 and ORION-11 Phase 3 randomised trials.
8620,30292,37997755,10.1080/13543784.2023.2288075,assay,ASO/siRNA,PubMed abstract sentence 3,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Gene expression inhibitors for the treatment of liver fibrosis: drugs under preclinical and early clinical investigation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Gene expression inhibitors for the treatment of liver fibrosis: drugs under preclinical and early clinical investigation.
8621,30293,37997755,10.1080/13543784.2023.2288075,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gene expression inhibitors for the treatment of liver fibrosis: drugs under preclinical and early clinical investigation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gene expression inhibitors for the treatment of liver fibrosis: drugs under preclinical and early clinical investigation.
8624,30306,37981738,10.1021/acschembio.3c00612,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery.
8633,30349,37944524,10.1016/j.chembiol.2023.10.010,delivery,ASO,PubMed abstract sentence 5,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy.
8636,30356,37939613,10.1016/j.biopha.2023.115819,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Harnessing the multifunctionality of lipid-based drug delivery systems for the local treatment of osteoarthritis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Harnessing the multifunctionality of lipid-based drug delivery systems for the local treatment of osteoarthritis.
8638,30360,37928900,10.3389/fcell.2023.1274040,assay,ASO/siRNA,PubMed abstract sentence 9,screen;preclinical;model,"assay candidate; matched derived terms: screen, preclinical, model; source title: Stem cell models of Angelman syndrome.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Stem cell models of Angelman syndrome.
8639,30361,37928900,10.3389/fcell.2023.1274040,benchmark,ASO/siRNA,PubMed abstract sentence 8,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Stem cell models of Angelman syndrome.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Stem cell models of Angelman syndrome.
8646,30390,37898358,10.1016/j.canlet.2023.216461,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Precise delivery of celastrol by PEGylated aptamer dendrimer nanoconjugates for enormous therapeutic effect via superior intratumor penetration over antibody counterparts.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Precise delivery of celastrol by PEGylated aptamer dendrimer nanoconjugates for enormous therapeutic effect via superior intratumor penetration over antibody counterparts.
8651,30411,37889063,10.21873/cgp.20401,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Hepatocellular Carcinoma: Up-regulated Circular RNAs Which Mediate Efficacy in Preclinical In Vivo Models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hepatocellular Carcinoma: Up-regulated Circular RNAs Which Mediate Efficacy in Preclinical In Vivo Models.
8658,30442,37860278,10.1080/2162402X.2023.2255041,assay,ASO/siRNA,PubMed abstract sentence 1,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Preclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody.
8668,30482,37828105,10.1038/s41417-023-00673-4,benchmark,ASO/siRNA,PubMed abstract sentence 9,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Exploration of a screening model for intrahepatic cholangiocarcinoma patients prone to cuproptosis and mechanisms of the susceptibility of CD274-knockdown intrahepatic cholangiocarcinoma cells to cuproptosis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exploration of a screening model for intrahepatic cholangiocarcinoma patients prone to cuproptosis and mechanisms of the susceptibility of CD274-knockdown intrahepatic cholangiocarcinoma cells to cuproptosis.
8671,30491,37818360,10.3389/fimmu.2023.1187108,assay,ASO/siRNA,PubMed abstract sentence 8,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Identification of molecular pattern and prognostic risk model based on ligand-receptor pairs in liver cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of molecular pattern and prognostic risk model based on ligand-receptor pairs in liver cancer.
8679,30539,37759179,10.1186/s12864-023-09562-4,assay,ASO/siRNA,PubMed abstract sentence 4,model;rna-seq,"assay candidate; matched derived terms: model, rna-seq; source title: Analysis of asymptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Analysis of asymptomatic Drosophila models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration.
8683,30551,37744174,10.1016/j.omtn.2023.09.001,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression.
8685,30557,37741460,10.1016/j.jconrel.2023.09.032,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Protein-based delivery systems for RNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Protein-based delivery systems for RNA delivery.
8689,30571,37731726,10.1093/nsr/nwad113,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Regulating the properties of XQ-2d for targeted delivery of therapeutic agents to pancreatic cancers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Regulating the properties of XQ-2d for targeted delivery of therapeutic agents to pancreatic cancers.
8690,30580,37724853,10.1039/d3nr02816j,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model.
8698,30614,37696583,10.1124/pharmrev.123.000815,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Targeting the Liver with Nucleic Acid Therapeutics for the Treatment of Systemic Diseases of Liver Origin.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting the Liver with Nucleic Acid Therapeutics for the Treatment of Systemic Diseases of Liver Origin.
8700,30620,37690731,10.3168/jds.2023-23602,assay,ASO/siRNA,PubMed abstract sentence 5,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Subclinical ketosis leads to lipid metabolism disorder by downregulating the expression of acetyl-coenzyme A acetyltransferase 2 in dairy cows.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Subclinical ketosis leads to lipid metabolism disorder by downregulating the expression of acetyl-coenzyme A acetyltransferase 2 in dairy cows.
8703,30643,37657644,10.1016/j.addr.2023.115073,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;galnac;lnp,"delivery candidate; matched derived terms: nanoparticle, galnac, lnp; source title: RNAi therapies: Expanding applications for extrahepatic diseases and overcoming delivery challenges.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi therapies: Expanding applications for extrahepatic diseases and overcoming delivery challenges.
8707,30663,37631235,10.3390/pharmaceutics15082021,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Polymeric-Micelle-Based Delivery Systems for Nucleic Acids.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Polymeric-Micelle-Based Delivery Systems for Nucleic Acids.
8709,30667,37625679,10.1016/j.actbio.2023.08.039,delivery,siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Direct cytoplasmic delivery of RNAi therapeutics through a non-lysosomal pathway for enhanced gene therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Direct cytoplasmic delivery of RNAi therapeutics through a non-lysosomal pathway for enhanced gene therapy.
8714,30684,37603945,10.1158/2326-6066.CIR-23-0045,assay,ASO/siRNA,PubMed abstract sentence 5,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Targeted Inhibition of lncRNA Malat1 Alters the Tumor Immune Microenvironment in Preclinical Syngeneic Mouse Models of Triple-Negative Breast Cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted Inhibition of lncRNA Malat1 Alters the Tumor Immune Microenvironment in Preclinical Syngeneic Mouse Models of Triple-Negative Breast Cancer.
8723,30717,37572288,10.1007/978-1-0716-3417-2_19,delivery,ASO/siRNA,PubMed abstract sentence 9,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Aptamer Conjugated RNA/DNA Hybrid Nanostructures Designed for Efficient Regulation of Blood Coagulation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer Conjugated RNA/DNA Hybrid Nanostructures Designed for Efficient Regulation of Blood Coagulation.
8724,30722,37572081,10.1080/14737175.2023.2246658,assay,ASO/siRNA,PubMed abstract sentence 8,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Viltolarsen: a treatment option for Duchenne muscular dystrophy patients who are amenable to exon 53 skipping therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Viltolarsen: a treatment option for Duchenne muscular dystrophy patients who are amenable to exon 53 skipping therapy.
8726,30730,37561647,10.1021/acs.molpharmaceut.3c00439,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Complex Coacervates as a Promising Vehicle for mRNA Delivery: A Comprehensive Review of Recent Advances and Challenges.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Complex Coacervates as a Promising Vehicle for mRNA Delivery: A Comprehensive Review of Recent Advances and Challenges.
8749,30841,37464094,10.1038/s12276-023-01044-7,assay,ASO/siRNA,PubMed abstract sentence 5,screen;model,"assay candidate; matched derived terms: screen, model; source title: Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model.
8751,30845,37463538,10.1016/j.foodchem.2023.136857,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: A novel electrochemical aptasensor based on core-shell nanomaterial labeling for simultaneous detection of acetamiprid and malathion.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A novel electrochemical aptasensor based on core-shell nanomaterial labeling for simultaneous detection of acetamiprid and malathion.
8753,30851,37457134,10.20517/cdr.2023.16,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Recent advances in access to overcome cancer drug resistance by nanocarrier drug delivery system.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Recent advances in access to overcome cancer drug resistance by nanocarrier drug delivery system.
8755,30857,37451914,10.1016/j.clinthera.2023.06.011,toxicity,ASO/siRNA,PubMed abstract sentence 2,risk;tolerability,"toxicity candidate; matched derived terms: risk, tolerability; source title: Inclisiran for the Treatment of Hyperlipidemia and for Atherosclerotic Cardiovascular Disease Risk Reduction: A Narrative Review.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inclisiran for the Treatment of Hyperlipidemia and for Atherosclerotic Cardiovascular Disease Risk Reduction: A Narrative Review.
8762,30886,30095329,10.1089/nat.2018.0724,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic;risk;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, risk, hepatotoxicity; source title: Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides.
8763,30887,30095329,10.1089/nat.2018.0724,offtarget,ASO,PubMed abstract sentence 7,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides.
8764,30890,40120651,10.1016/j.taap.2025.117308,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: β-Sitosterol protects against lithocholic acid-induced hepatotoxicity and cholestasis via farnesoid X receptor-mediated regulation of transporters and enzymes in vitro and in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,β-Sitosterol protects against lithocholic acid-induced hepatotoxicity and cholestasis via farnesoid X receptor-mediated regulation of transporters and enzymes in vitro and in vivo.
8765,30893,39993461,10.1016/j.fct.2025.115335,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition.
8766,30896,39947414,10.1016/j.tiv.2025.106020,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: β-sitosterol protects against ANIT-induced hepatotoxicity and cholestasis via FXR activation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,β-sitosterol protects against ANIT-induced hepatotoxicity and cholestasis via FXR activation.
8767,30899,39676252,10.1093/jb/mvae086,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Species-specific differences in acetaminophen hepatotoxicity depend on HSP70 expression level.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Species-specific differences in acetaminophen hepatotoxicity depend on HSP70 expression level.
8769,30903,39684010,10.3390/polym16233265,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bio-Inspired Polymeric Solid Lipid Nanoparticles for siRNA Delivery: Cytotoxicity and Cellular Uptake In Vitro.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Bio-Inspired Polymeric Solid Lipid Nanoparticles for siRNA Delivery: Cytotoxicity and Cellular Uptake In Vitro.
8771,30909,39366156,10.1016/j.phymed.2024.156106,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Artemisia Argyi essential oil ameliorates acetaminophen-induced hepatotoxicity via CYP2E1 and γ-glutamyl cycle reprogramming.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Artemisia Argyi essential oil ameliorates acetaminophen-induced hepatotoxicity via CYP2E1 and γ-glutamyl cycle reprogramming.
8772,30912,36700050,10.1016/j.omtn.2022.12.010,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route.
8776,30920,30817231,10.1089/nat.2019.0781,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Extrapolation of Oligonucleotide Dose Levels Used in Nonclinical Toxicity Studies to Selection of Safe Starting Dose Levels in Human Clinical Trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Extrapolation of Oligonucleotide Dose Levels Used in Nonclinical Toxicity Studies to Selection of Safe Starting Dose Levels in Human Clinical Trials.
8777,30923,29202008,10.1016/j.omto.2017.10.003,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB.
8779,30927,40072078,10.3390/cells14050349,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Caki-1 Spheroids as a Renal Model for Studying Free Fatty Acid-Induced Lipotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Caki-1 Spheroids as a Renal Model for Studying Free Fatty Acid-Induced Lipotoxicity.
8782,30934,29360004,10.1089/nat.2017.0698,chemistry,ASO,PubMed abstract sentence 4,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides.
8783,30935,29360004,10.1089/nat.2017.0698,delivery,ASO,PubMed abstract sentence 4,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides.
8784,30936,29360004,10.1089/nat.2017.0698,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides.
8787,30941,39829590,10.1021/acsomega.4c08314,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Comparative Study of Functionalized Carbosilane Dendrimers for siRNA Delivery: Synthesis, Cytotoxicity, and Biophysical Properties.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Comparative Study of Functionalized Carbosilane Dendrimers for siRNA Delivery: Synthesis, Cytotoxicity, and Biophysical Properties."
8790,30946,39460726,10.1021/acsami.4c10171,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Mitigation of Cisplatin-Induced Nephrotoxicity and Augmentation of Anticancer Potency via Tea Polyphenol Nanoparticles' Codelivery of siRNA from CRISPR/Cas9 Screened Targets.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mitigation of Cisplatin-Induced Nephrotoxicity and Augmentation of Anticancer Potency via Tea Polyphenol Nanoparticles' Codelivery of siRNA from CRISPR/Cas9 Screened Targets.
8791,30949,26978711,10.1089/nat.2015.0534,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: OSWG Recommendations for Genotoxicity Testing of Novel Oligonucleotide-Based Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,OSWG Recommendations for Genotoxicity Testing of Novel Oligonucleotide-Based Therapeutics.
8792,30952,39231537,10.1093/nar/gkae741,offtarget,siRNA,PubMed abstract sentence 1,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Synthesis of 2'-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Synthesis of 2'-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs.
8794,30956,39690144,10.1080/14740338.2024.2443796,toxicity,ASO/siRNA,PubMed abstract sentence 2,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Adverse events of nusinersen: a real-world drug safety surveillance study based on the FDA adverse event reporting system (FAERS) database.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Adverse events of nusinersen: a real-world drug safety surveillance study based on the FDA adverse event reporting system (FAERS) database.
8797,30963,41216931,10.1210/endocr/bqaf168,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Androgen Receptors Promote Oxidative Phosphorylation and Resistance to Palmitate Lipotoxicity in ER-Mutant Breast Cancer.
8798,30966,41151699,10.1016/j.fitote.2025.106941,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Shengmaisan combined with Liuwei Dihuang Decoction alleviated CIH-induced glutamate excitotoxicity by IGF1/IGFR signaling pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Shengmaisan combined with Liuwei Dihuang Decoction alleviated CIH-induced glutamate excitotoxicity by IGF1/IGFR signaling pathway.
8799,30969,41005676,10.1016/j.ibmb.2025.104407,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: V-ATPase B mediates Bt Cry1Ac binding and toxicity in Grapholita molesta.",B,high_candidate,curator_rejected,reject,derived_annotations_only,V-ATPase B mediates Bt Cry1Ac binding and toxicity in Grapholita molesta.
8800,30972,40181752,10.1021/acs.jafc.4c13080,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Knockdown of Oatp and Mdr Transporter Genes Enhances Cardenolide Toxicity to the Noncardenolide Feeder, Nilaparvata lugens.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Knockdown of Oatp and Mdr Transporter Genes Enhances Cardenolide Toxicity to the Noncardenolide Feeder, Nilaparvata lugens."
8802,30976,40157939,10.1038/s41419-025-07538-8,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cytoplasmic accumulation of a splice variant of hnRNPA2/B1 contributes to FUS-associated toxicity in a mouse model of ALS.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cytoplasmic accumulation of a splice variant of hnRNPA2/B1 contributes to FUS-associated toxicity in a mouse model of ALS.
8804,30980,40069794,10.1186/s40360-025-00897-0,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: AMD1, a cardiotoxicity target for Maduramicin.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"AMD1, a cardiotoxicity target for Maduramicin."
8806,30986,39933533,10.1111/bph.17468,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin-induced cardiotoxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin-induced cardiotoxicity.
8807,30989,39734056,10.1016/j.freeradbiomed.2024.12.049,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipotoxicity-induced upregulation of FIS1 exacerbates mitochondrial fragmentation and promotes NLRP3-dependent pyroptosis in diabetic cardiomyopathy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipotoxicity-induced upregulation of FIS1 exacerbates mitochondrial fragmentation and promotes NLRP3-dependent pyroptosis in diabetic cardiomyopathy.
8808,30992,39303612,10.1016/j.jhazmat.2024.135909,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Activated hedgehog and insulin ligands by decreased transcriptional factor DAF-16 mediate transgenerational nanoplastic toxicity in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Activated hedgehog and insulin ligands by decreased transcriptional factor DAF-16 mediate transgenerational nanoplastic toxicity in Caenorhabditis elegans.
8809,30995,39298552,10.1152/ajprenal.00026.2024,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: COMMD5 counteracts cisplatin-induced nephrotoxicity by maintaining tubular epithelial integrity and autophagy flux.",B,high_candidate,curator_rejected,reject,derived_annotations_only,COMMD5 counteracts cisplatin-induced nephrotoxicity by maintaining tubular epithelial integrity and autophagy flux.
8810,30998,39195657,10.3390/toxics12080555,chemistry,ASO/siRNA,PubMed abstract sentence 3,modification;modified,"chemistry candidate; matched derived terms: modification, modified; source title: Comparison of Transgenerational Neurotoxicity between Pristine and Amino-Modified Nanoplastics in C. elegans.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comparison of Transgenerational Neurotoxicity between Pristine and Amino-Modified Nanoplastics in C. elegans.
8811,30999,39195657,10.3390/toxics12080555,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Comparison of Transgenerational Neurotoxicity between Pristine and Amino-Modified Nanoplastics in C. elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comparison of Transgenerational Neurotoxicity between Pristine and Amino-Modified Nanoplastics in C. elegans.
8812,31002,39098352,10.1016/j.chemosphere.2024.143011,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans.
8814,31006,39004367,10.1016/j.scitotenv.2024.174766,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Amino-modified nanoplastics at predicted environmental concentrations cause transgenerational toxicity through activating germline EGF signal in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Amino-modified nanoplastics at predicted environmental concentrations cause transgenerational toxicity through activating germline EGF signal in Caenorhabditis elegans.
8815,31009,38184283,10.1016/j.toxicon.2024.107603,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Mitigation of arsenic poisoning induced oxidative stress and genotoxicity by Ocimum gratissimum L.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mitigation of arsenic poisoning induced oxidative stress and genotoxicity by Ocimum gratissimum L.
8818,31016,37888299,10.1158/1078-0432.CCR-23-1568,toxicity,ASO/siRNA,PubMed abstract sentence 18,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials.
8820,31020,37489508,10.1177/01926233231179707,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studies."
8821,31023,36934948,10.1016/j.scitotenv.2023.162928,toxicity,ASO/siRNA,PubMed abstract sentence 12,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Regulation of arsenite toxicity in lettuce by pyrite and glutamic acid and the related mechanism.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Regulation of arsenite toxicity in lettuce by pyrite and glutamic acid and the related mechanism.
8822,31026,36668798,10.3390/toxics11010072,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Epigenetics and Methylmercury-Induced Neurotoxicity, Evidence from Experimental Studies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Epigenetics and Methylmercury-Induced Neurotoxicity, Evidence from Experimental Studies."
8824,31030,36087010,10.1093/toxsci/kfac091,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells."
8827,31037,39775205,10.1371/journal.pntd.0012788,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naïve adults.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naïve adults."
8829,31041,40178804,10.1039/d5bm00363f,chemistry,siRNA,PubMed abstract sentence 4,galnac;lna,"chemistry candidate; matched derived terms: galnac, lna; source title: GalNAc-functionalized metal-organic frameworks for targeted siRNA delivery: enhancing survivin silencing in hepatocellular carcinoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-functionalized metal-organic frameworks for targeted siRNA delivery: enhancing survivin silencing in hepatocellular carcinoma.
8835,31049,39348656,,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A novel, non-toxic chitosan modified with lysine to enhance buffer capacity for siRNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"A novel, non-toxic chitosan modified with lysine to enhance buffer capacity for siRNA delivery."
8839,31057,39274180,10.3390/polym16172547,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices.
8842,31062,39231845,10.1208/s12248-024-00967-x,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Liposomal Formulations of Anti-Alzheimer Drugs and siRNA for Nose-to-Brain Delivery: Design, Safety and Efficacy In Vitro.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Liposomal Formulations of Anti-Alzheimer Drugs and siRNA for Nose-to-Brain Delivery: Design, Safety and Efficacy In Vitro."
8846,31070,38048134,10.1001/jamanetworkopen.2023.44938,assay,ASO/siRNA,PubMed abstract sentence 4,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Efficacy and Safety of Cilostazol in Mild Cognitive Impairment: A Randomized Clinical Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficacy and Safety of Cilostazol in Mild Cognitive Impairment: A Randomized Clinical Trial.
8847,31071,38048134,10.1001/jamanetworkopen.2023.44938,toxicity,ASO/siRNA,PubMed abstract sentence 11,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Efficacy and Safety of Cilostazol in Mild Cognitive Impairment: A Randomized Clinical Trial.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy and Safety of Cilostazol in Mild Cognitive Impairment: A Randomized Clinical Trial.
8850,31078,36678723,10.3390/pharmaceutics15010095,assay,ASO,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Smad7 Antisense Oligonucleotide in Crohn's Disease: A Re-Evaluation and Explanation for the Discordant Results of Clinical Trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Smad7 Antisense Oligonucleotide in Crohn's Disease: A Re-Evaluation and Explanation for the Discordant Results of Clinical Trials.
8851,31081,36406277,10.3389/fmolb.2022.887678,delivery,ASO,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lipid nanoparticles for antisense oligonucleotide gene interference into brain border-associated macrophages.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles for antisense oligonucleotide gene interference into brain border-associated macrophages.
8853,31085,33054599,10.1089/nat.2020.0892,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Outcomes of the European Federation of Pharmaceutical Industries and Associations Oligonucleotide Working Group Survey on Nonclinical Practices and Regulatory Expectations for Therapeutic Oligonucleotide Safety Assessment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Outcomes of the European Federation of Pharmaceutical Industries and Associations Oligonucleotide Working Group Survey on Nonclinical Practices and Regulatory Expectations for Therapeutic Oligonucleotide Safety Assessment.
8855,31091,31063435,10.1089/nat.2018.0767,offtarget,siRNA,PubMed abstract sentence 6,off-target;mismatch,"offtarget candidate; matched derived terms: off-target, mismatch; source title: Use of ""C9/11 Mismatch"" Control siRNA Reveals Sequence-Related Off-Target Effect on Coagulation of an siRNA Targeting Mouse Coagulation Factor XII.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Use of ""C9/11 Mismatch"" Control siRNA Reveals Sequence-Related Off-Target Effect on Coagulation of an siRNA Targeting Mouse Coagulation Factor XII."
8856,31094,29792572,10.1089/nat.2018.0736,chemistry,siRNA,PubMed abstract sentence 4,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics.
8857,31095,29792572,10.1089/nat.2018.0736,delivery,siRNA,PubMed abstract sentence 4,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics.
8859,31099,28981809,10.1093/nar/gkx818,chemistry,siRNA,PubMed abstract sentence 1,chemical;modified;galnac;lna,"chemistry candidate; matched derived terms: chemical, modified, galnac, lna; source title: Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.
8860,31100,28981809,10.1093/nar/gkx818,delivery,siRNA,PubMed abstract sentence 1,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates.
8865,31115,39068444,10.1186/s12951-024-02700-4,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PD-L1 siRNA hitched polyethyleneimine-elastase constituting nanovesicle induces tumor immunogenicity and PD-L1 silencing for synergistic antitumor immunotherapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,PD-L1 siRNA hitched polyethyleneimine-elastase constituting nanovesicle induces tumor immunogenicity and PD-L1 silencing for synergistic antitumor immunotherapy.
8873,31131,32818923,10.1016/j.omtn.2020.07.029,chemistry,siRNA,PubMed abstract sentence 2,chemical;modified;phosphorothioate;conjugate,"chemistry candidate; matched derived terms: chemical, modified, phosphorothioate, conjugate; source title: Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy.
8874,31132,32818923,10.1016/j.omtn.2020.07.029,delivery,siRNA,PubMed abstract sentence 2,conjugated;uptake,"delivery candidate; matched derived terms: conjugated, uptake; source title: Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy.
8879,31147,39924636,10.1007/s12033-024-01340-1,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;dna damage,"toxicity candidate; matched derived terms: toxicity, toxic, dna damage; source title: Sodium Alginate Attenuates H(2)O(2)-Induced Myocardial DNA Damage via VSNL1 Regulating the CNP/NPR-B Signaling Pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sodium Alginate Attenuates H(2)O(2)-Induced Myocardial DNA Damage via VSNL1 Regulating the CNP/NPR-B Signaling Pathway.
8881,31151,41275747,10.1016/j.phymed.2025.157564,toxicity,ASO/siRNA,PubMed abstract sentence 14,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Atractylenolide I activates the DNA damage-apoptosis axis in colorectal cancer patient-derived organoids by dual-targeting XRCC5 and CLTC.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Atractylenolide I activates the DNA damage-apoptosis axis in colorectal cancer patient-derived organoids by dual-targeting XRCC5 and CLTC.
8887,31165,40409597,10.1016/j.imlet.2025.107033,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: The role of DAMP cytotoxic fractions in the immune markers' disruption in patients with urgent surgical pathology and against the background of post-COVID-19 syndrome.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The role of DAMP cytotoxic fractions in the immune markers' disruption in patients with urgent surgical pathology and against the background of post-COVID-19 syndrome.
8888,31168,40327996,10.1016/j.bmc.2025.118223,delivery,ASO,PubMed abstract sentence 4,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Screening and evaluation of hydrophobic cell-penetrating peptides for antisense oligonucleotide delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Screening and evaluation of hydrophobic cell-penetrating peptides for antisense oligonucleotide delivery.
8893,31179,40044032,10.1016/j.lfs.2025.123527,chemistry,ASO,PubMed abstract sentence 5,modification;2'-o,"chemistry candidate; matched derived terms: modification, 2'-o; source title: SNORD9 promotes ovarian cancer tumorigenesis via METTL3/IGF2BP2-mediated NFYA m6A modification and is a potential target for antisense oligonucleotide therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,SNORD9 promotes ovarian cancer tumorigenesis via METTL3/IGF2BP2-mediated NFYA m6A modification and is a potential target for antisense oligonucleotide therapy.
8895,31183,40011938,10.1186/s13023-025-03603-9,toxicity,ASO/siRNA,PubMed abstract sentence 7,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Real-world analysis of the efficacy and safety of nusinersen in pediatric patients with spinal muscular atrophy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Real-world analysis of the efficacy and safety of nusinersen in pediatric patients with spinal muscular atrophy.
8898,31190,39960588,10.1007/s12325-024-03101-7,toxicity,ASO/siRNA,PubMed abstract sentence 10,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Motor Function and Safety of Nusinersen and Risdiplam in Asian Patients with Types 2-4 Spinal Muscular Atrophy (SMA): A Systematic Review and Meta-Analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Motor Function and Safety of Nusinersen and Risdiplam in Asian Patients with Types 2-4 Spinal Muscular Atrophy (SMA): A Systematic Review and Meta-Analysis.
8901,31201,39813044,10.1021/acschembio.4c00824,offtarget,ASO/siRNA,PubMed abstract sentence 3,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Amide Internucleoside Linkages Suppress the MicroRNA-like Off-Target Activity of Short Interfering RNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Amide Internucleoside Linkages Suppress the MicroRNA-like Off-Target Activity of Short Interfering RNA.
8903,31207,39694272,10.1016/j.xphs.2024.12.013,delivery,siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Recent advances in drying and development of solid formulations for stable mRNA and siRNA lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent advances in drying and development of solid formulations for stable mRNA and siRNA lipid nanoparticles.
8908,31222,39021326,10.1002/smtd.202400622,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Spatial Organization of Lipid Nanoparticle siRNA Delivery Systems Revealed by an Integrated Magnetic Resonance Approach.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Spatial Organization of Lipid Nanoparticle siRNA Delivery Systems Revealed by an Integrated Magnetic Resonance Approach.
8913,31233,39554995,10.1016/j.omtn.2024.102362,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Profiling patent compounds in lipid nanoparticle formulations of siRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Profiling patent compounds in lipid nanoparticle formulations of siRNA.
8915,31239,39456041,10.1186/s12951-024-02946-y,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Targeting FAP-positive chondrocytes in osteoarthritis: a novel lipid nanoparticle siRNA approach to mitigate cartilage degeneration.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting FAP-positive chondrocytes in osteoarthritis: a novel lipid nanoparticle siRNA approach to mitigate cartilage degeneration.
8918,31250,39196607,10.7554/eLife.92806,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Botulinum toxin intoxication requires retrograde transport and membrane translocation at the ER in RenVM neurons.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Botulinum toxin intoxication requires retrograde transport and membrane translocation at the ER in RenVM neurons.
8919,31253,39163516,10.1021/acsami.4c04893,delivery,ASO,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Antisense Oligonucleotide Embedded Context Responsive Nanoparticles Derived from Synthetic Ionizable Lipids for lncRNA Targeted Therapy of Breast Cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense Oligonucleotide Embedded Context Responsive Nanoparticles Derived from Synthetic Ionizable Lipids for lncRNA Targeted Therapy of Breast Cancer.
8920,31256,39158541,10.1097/SHK.0000000000002450,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: THE DELIVERY OF PD-L1 SIRNA BY NEUTROPHIL-TARGETED LIPID NANOPARTICLES EFFECTIVELY AMELIORATES SEPSIS.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,THE DELIVERY OF PD-L1 SIRNA BY NEUTROPHIL-TARGETED LIPID NANOPARTICLES EFFECTIVELY AMELIORATES SEPSIS.
8922,31260,39144399,10.1021/acsanm.4c02996,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Antifibrotic and Pro-regenerative Effects of SMAD3 siRNA and Collagen I mRNA-Loaded Lipid Nanoparticles in Human Tenocytes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antifibrotic and Pro-regenerative Effects of SMAD3 siRNA and Collagen I mRNA-Loaded Lipid Nanoparticles in Human Tenocytes.
8924,31264,39136364,10.1002/mus.28228,toxicity,ASO/siRNA,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Safety of risdiplam in spinal muscular atrophy patients after short-term treatment with nusinersen.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety of risdiplam in spinal muscular atrophy patients after short-term treatment with nusinersen.
8925,31267,39122031,10.1016/j.scitotenv.2024.175311,toxicity,ASO/siRNA,PubMed abstract sentence 7,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Silence is not always golden: A closer look at potential environmental and ecotoxicological impacts of large-scale dsRNA application.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silence is not always golden: A closer look at potential environmental and ecotoxicological impacts of large-scale dsRNA application.
8926,31270,39102908,10.1016/j.ijbiomac.2024.134478,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticle-mediated calmodulin dsRNA and cyantraniliprole co-delivery system: High-efficient control of two key pear pests while ensuring safety for natural enemy insects.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticle-mediated calmodulin dsRNA and cyantraniliprole co-delivery system: High-efficient control of two key pear pests while ensuring safety for natural enemy insects.
8931,31285,37769917,10.1016/j.chemosphere.2023.140292,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Mechanistic insights into the leaching and environmental safety of arsenic in ceramsite prepared from fly ash.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mechanistic insights into the leaching and environmental safety of arsenic in ceramsite prepared from fly ash.
8933,31293,37659896,10.1016/j.vaccine.2023.08.053,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Developmental and reproductive safety of Advax-CpG55.2™ adjuvanted COVID-19 and influenza vaccines in mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Developmental and reproductive safety of Advax-CpG55.2™ adjuvanted COVID-19 and influenza vaccines in mice.
8934,31296,37532145,10.1016/j.jconrel.2023.07.054,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lipid nanoparticles for siRNA delivery in cancer treatment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles for siRNA delivery in cancer treatment.
8944,31320,37300792,10.1007/s13555-023-00939-7,assay,ASO/siRNA,PubMed abstract sentence 14,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Safety and Efficacy of a Novel Combination Cream (GN-037) in Healthy Volunteers and Patients with Plaque Psoriasis: A Phase 1 Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Safety and Efficacy of a Novel Combination Cream (GN-037) in Healthy Volunteers and Patients with Plaque Psoriasis: A Phase 1 Trial.
8945,31321,37300792,10.1007/s13555-023-00939-7,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Safety and Efficacy of a Novel Combination Cream (GN-037) in Healthy Volunteers and Patients with Plaque Psoriasis: A Phase 1 Trial.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safety and Efficacy of a Novel Combination Cream (GN-037) in Healthy Volunteers and Patients with Plaque Psoriasis: A Phase 1 Trial.
8946,31326,37076460,10.2174/1389200224666230418092626,chemistry,ASO,PubMed abstract sentence 1,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Factors Influencing ADME Properties of Therapeutic Antisense Oligonucleotides: Physicochemical Characteristics and Beyond.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Factors Influencing ADME Properties of Therapeutic Antisense Oligonucleotides: Physicochemical Characteristics and Beyond.
8959,31365,36577600,10.1016/j.atherosclerosis.2022.12.003,delivery,ASO,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeting and delivery of microRNA-targeting antisense oligonucleotides in cardiovascular diseases.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting and delivery of microRNA-targeting antisense oligonucleotides in cardiovascular diseases.
8961,31369,36529659,10.1016/j.jacl.2022.12.001,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Efficacy and safety of pelacarsen in lowering Lp(a) in healthy Japanese subjects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficacy and safety of pelacarsen in lowering Lp(a) in healthy Japanese subjects.
8963,31377,36569303,10.3389/fphar.2022.1061842,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense oligonucleotide is a promising intervention for liver diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense oligonucleotide is a promising intervention for liver diseases.
8964,31382,36037209,10.1371/journal.pone.0273509,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming."
8966,31386,35858356,10.1073/pnas.2113180119,chemistry,ASO,PubMed abstract sentence 5,chemical;modified;conjugate,"chemistry candidate; matched derived terms: chemical, modified, conjugate; source title: Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides.
8971,31401,33863777,10.1158/0008-5472.CAN-20-2694,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.
8975,31413,32517377,10.3390/pharmaceutics12060520,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Resveratrol Enhances mRNA and siRNA Lipid Nanoparticles Primary CLL Cell Transfection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Resveratrol Enhances mRNA and siRNA Lipid Nanoparticles Primary CLL Cell Transfection.
8978,31422,31877238,10.1002/jat.3938,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Safety of bovine milk derived extracellular vesicles used for delivery of RNA therapeutics in zebrafish and mice.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Safety of bovine milk derived extracellular vesicles used for delivery of RNA therapeutics in zebrafish and mice.
8979,31423,31877238,10.1002/jat.3938,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Safety of bovine milk derived extracellular vesicles used for delivery of RNA therapeutics in zebrafish and mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Safety of bovine milk derived extracellular vesicles used for delivery of RNA therapeutics in zebrafish and mice.
8982,31430,31410799,10.1007/978-1-4939-9670-4_12,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro and In Vivo Application in the Context of Spinal Cord Injury.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro and In Vivo Application in the Context of Spinal Cord Injury.
8985,31437,31097994,10.1021/acsmedchemlett.8b00652,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles.
8986,31442,31063396,10.1021/acs.molpharmaceut.8b01290,delivery,ASO,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides.
8988,31446,30801231,10.1089/nat.2018.0770,chemistry,siRNA,PubMed abstract sentence 3,chemical;modification;conjugate,"chemistry candidate; matched derived terms: chemical, modification, conjugate; source title: Quantification of siRNA-Antibody Conjugates in Biological Matrices by Triplex-Forming Oligonucleotide ELISA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Quantification of siRNA-Antibody Conjugates in Biological Matrices by Triplex-Forming Oligonucleotide ELISA.
8992,31454,30133341,10.1089/nat.2018.0723,chemistry,ASO,PubMed abstract sentence 1,modification;phosphorothioate;2'-o;2'-moe,"chemistry candidate; matched derived terms: modification, phosphorothioate, 2'-o, 2'-moe; source title: Characterization of the Activity and Distribution of a 2'-O-Methoxyethyl-Modified Antisense Oligonucleotide in Models of Acute and Chronic Kidney Disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Characterization of the Activity and Distribution of a 2'-O-Methoxyethyl-Modified Antisense Oligonucleotide in Models of Acute and Chronic Kidney Disease.
8993,31455,30133341,10.1089/nat.2018.0723,assay,ASO,PubMed abstract sentence 1,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Characterization of the Activity and Distribution of a 2'-O-Methoxyethyl-Modified Antisense Oligonucleotide in Models of Acute and Chronic Kidney Disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Characterization of the Activity and Distribution of a 2'-O-Methoxyethyl-Modified Antisense Oligonucleotide in Models of Acute and Chronic Kidney Disease.
8996,31460,30112821,10.1002/anie.201809056,delivery,siRNA,PubMed abstract sentence 6,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs.
9001,31471,29377001,10.1038/nchembio.2559,offtarget,ASO/siRNA,PubMed abstract sentence 5,off-target;mismatch,"offtarget candidate; matched derived terms: off-target, mismatch; source title: Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.
9003,31477,28624200,10.1016/j.omtn.2017.04.003,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA.
9004,31478,28624200,10.1016/j.omtn.2017.04.003,assay,siRNA,PubMed abstract sentence 3,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA.
9006,31480,28624200,10.1016/j.omtn.2017.04.003,benchmark,siRNA,PubMed abstract sentence 2,model;tool,"benchmark candidate; matched derived terms: model, tool; source title: Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA.
9014,31496,28325278,10.1016/j.omtn.2016.12.003,chemistry,ASO/siRNA,PubMed abstract sentence 2,galnac;lna,"chemistry candidate; matched derived terms: galnac, lna; source title: Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics.
9015,31497,28325278,10.1016/j.omtn.2016.12.003,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics.
9017,31507,27462152,10.2147/IJN.S106625,delivery,siRNA,PubMed abstract sentence 1,delivery;lnp,"delivery candidate; matched derived terms: delivery, lnp; source title: Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside.
9045,31571,40362576,10.3390/ijms26094340,offtarget,ASO/siRNA,PubMed abstract sentence 6,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell Transcriptome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell Transcriptome.
9052,31592,40161739,10.1101/2025.03.12.642862,offtarget,ASO/siRNA,PubMed abstract sentence 6,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell Transcriptome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell Transcriptome.
9059,31611,40055791,10.1186/s12967-025-06177-z,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers.
9069,31631,39896757,10.34133/bmr.0136,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic;safety;renal,"toxicity candidate; matched derived terms: toxicity, toxic, safety, renal; source title: Isoprenaline-Modified Polyethyleneimine as an Efficient Gene Delivery System for Targeted Asthma Therapy and Airway Remodeling Inhibition.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Isoprenaline-Modified Polyethyleneimine as an Efficient Gene Delivery System for Targeted Asthma Therapy and Airway Remodeling Inhibition.
9079,31657,39509543,10.1021/acssensors.4c02739,benchmark,ASO/siRNA,PubMed abstract sentence 6,model;prediction,"benchmark candidate; matched derived terms: model, prediction; source title: Microfluidic Optical Aptasensor for Small Molecules Based on Analyte-Tuned Growth of Gold Nanoseeds and Machine Learning-Enhanced Spectrum Analysis: Rapid Detection of Mycotoxins.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Microfluidic Optical Aptasensor for Small Molecules Based on Analyte-Tuned Growth of Gold Nanoseeds and Machine Learning-Enhanced Spectrum Analysis: Rapid Detection of Mycotoxins.
9080,31660,39503523,10.1093/bib/bbae563,benchmark,siRNA,PubMed abstract sentence 8,model;benchmark,"benchmark candidate; matched derived terms: model, benchmark; source title: siRNADiscovery: a graph neural network for siRNA efficacy prediction via deep RNA sequence analysis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNADiscovery: a graph neural network for siRNA efficacy prediction via deep RNA sequence analysis.
9094,31694,37014877,10.1371/journal.pone.0283941,assay,ASO/siRNA,PubMed abstract sentence 6,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: A seeding-based neuronal model of tau aggregation for use in drug discovery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A seeding-based neuronal model of tau aggregation for use in drug discovery.
9108,31730,32311310,10.1089/nat.2020.0852,chemistry,ASO/siRNA,PubMed abstract sentence 3,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Pharmacodynamic and Pharmacokinetic Properties of Full Phosphorothioate Small Interfering RNAs for Gene Silencing In Vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pharmacodynamic and Pharmacokinetic Properties of Full Phosphorothioate Small Interfering RNAs for Gene Silencing In Vivo.
9119,31755,32326855,10.1080/09168451.2020.1756733,offtarget,ASO/siRNA,PubMed abstract sentence 2,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Transcriptome alterations in HepG2 cells induced by shRNA knockdown and overexpression of TMEM2 gene.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transcriptome alterations in HepG2 cells induced by shRNA knockdown and overexpression of TMEM2 gene.
9157,31847,41304812,10.3390/pharmaceutics17111476,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Heterofunctional Cationic Polyester Dendrimers as Potent Nonviral Vectors for siRNA Delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Heterofunctional Cationic Polyester Dendrimers as Potent Nonviral Vectors for siRNA Delivery.
9179,31909,40279154,10.1021/acs.biomac.5c00132,assay,siRNA,PubMed abstract sentence 6,model;experiment;trial,"assay candidate; matched derived terms: model, experiment, trial; source title: A Dual-Interaction Supramolecular Hydrogel System for siRNA Delivery to Enhance Endometrial Receptivity in Stem Cell Therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Dual-Interaction Supramolecular Hydrogel System for siRNA Delivery to Enhance Endometrial Receptivity in Stem Cell Therapy.
9182,31914,40274164,10.1016/j.ijbiomac.2025.143420,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tobramycin crosslinking improves the colloidal stability of arginine chitosan biodynamers for safe and efficient siRNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tobramycin crosslinking improves the colloidal stability of arginine chitosan biodynamers for safe and efficient siRNA delivery.
9189,31933,40192303,10.1002/cpz1.70128,chemistry,ASO,PubMed abstract sentence 1,modified;conjugate,"chemistry candidate; matched derived terms: modified, conjugate; source title: Synthesis of Prodrug-Type Oligonucleotides Modified With a Galactosylated Self-Immolative Linker Cleavable by β-Galactosidase.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synthesis of Prodrug-Type Oligonucleotides Modified With a Galactosylated Self-Immolative Linker Cleavable by β-Galactosidase.
9194,31946,40158445,10.1016/j.biomaterials.2025.123297,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Selective vascular disrupting therapy by lipid nanoparticle-mediated Fas ligand silencing and stimulation of STING.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Selective vascular disrupting therapy by lipid nanoparticle-mediated Fas ligand silencing and stimulation of STING.
9196,31952,40139450,10.1016/j.ijpharm.2025.125516,delivery,siRNA,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Targeted melanoma therapy: High-efficiency siRNA delivery with R8-PEI dissolvable microneedles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted melanoma therapy: High-efficiency siRNA delivery with R8-PEI dissolvable microneedles.
9222,32022,39899704,10.1021/acs.jmedchem.4c02250,chemistry,siRNA,PubMed abstract sentence 2,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3' End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3' End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain.
9223,32023,39899704,10.1021/acs.jmedchem.4c02250,delivery,siRNA,PubMed abstract sentence 1,delivery;galnac,"delivery candidate; matched derived terms: delivery, galnac; source title: Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3' End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3' End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain.
9224,32026,39854143,10.1002/cbic.202400987,chemistry,ASO,PubMed abstract sentence 6,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Recent Advances in Biocatalytic and Chemoenzymatic Synthesis of Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent Advances in Biocatalytic and Chemoenzymatic Synthesis of Oligonucleotides.
9235,32051,39753560,10.1038/s41467-024-55721-w,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Ionizable polymeric micelles (IPMs) for efficient siRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ionizable polymeric micelles (IPMs) for efficient siRNA delivery.
9246,32082,39629543,10.1002/smll.202407040,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Zwitterionic Polymer Lipid Nanoparticles Enabling Selective Organ Targeting Delivery of Small Interfering RNA for the Treatment of Hepatic and Pulmonary Inflammation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Zwitterionic Polymer Lipid Nanoparticles Enabling Selective Organ Targeting Delivery of Small Interfering RNA for the Treatment of Hepatic and Pulmonary Inflammation.
9248,32086,39613271,10.1016/j.ejpb.2024.114588,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Optimization and evaluation of gastroresistant microparticles designed for siRNA oral delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimization and evaluation of gastroresistant microparticles designed for siRNA oral delivery.
9259,32107,39551221,10.1016/j.ijpharm.2024.124960,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Neutrophil membrane-coated nanoparticles for targeted delivery of toll-like receptor 4 siRNA ameliorate LPS-induced acute lung injury.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Neutrophil membrane-coated nanoparticles for targeted delivery of toll-like receptor 4 siRNA ameliorate LPS-induced acute lung injury.
9261,32113,39498752,10.1002/smll.202405806,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: PEGylated Multimeric RNA Nanoparticles for siRNA Delivery in Traumatic Brain Injury.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,PEGylated Multimeric RNA Nanoparticles for siRNA Delivery in Traumatic Brain Injury.
9266,32124,39448881,10.1038/s41587-024-02448-0,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gold-siRNA supraclusters enhance the anti-tumor immune response of stereotactic ablative radiotherapy at primary and metastatic tumors.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Gold-siRNA supraclusters enhance the anti-tumor immune response of stereotactic ablative radiotherapy at primary and metastatic tumors.
9275,32147,39684325,10.3390/ijms252312614,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Non-Viral Systems Based on PAMAM-Calix-Dendrimers for Regulatory siRNA Delivery into Cancer Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Non-Viral Systems Based on PAMAM-Calix-Dendrimers for Regulatory siRNA Delivery into Cancer Cells.
9277,32153,39627280,10.1038/s41598-024-80646-1,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Polyethylene glycol-phospholipid functionalized single-walled carbon nanotubes for enhanced siRNA systemic delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Polyethylene glycol-phospholipid functionalized single-walled carbon nanotubes for enhanced siRNA systemic delivery.
9279,32159,39618014,10.1002/smll.202406082,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Introducing Degradable Cationic Nanogels Carrying TLR9 Stimulating Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Introducing Degradable Cationic Nanogels Carrying TLR9 Stimulating Oligonucleotides.
9285,32175,39583320,10.2147/IJN.S477597,delivery,siRNA,PubMed abstract sentence 5,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Aptamer sgc8-Modified PAMAM Nanoparticles for Targeted siRNA Delivery to Inhibit BCL11B in T-Cell Acute Lymphoblastic Leukemia.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer sgc8-Modified PAMAM Nanoparticles for Targeted siRNA Delivery to Inhibit BCL11B in T-Cell Acute Lymphoblastic Leukemia.
9291,32189,39539970,10.2147/IJN.S483252,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Stimuli-Responsive Peptide/siRNA Nanoparticles as a Radiation Sensitizer for Glioblastoma Treatment by Co-Inhibiting RELA/P65 and EGFR.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Stimuli-Responsive Peptide/siRNA Nanoparticles as a Radiation Sensitizer for Glioblastoma Treatment by Co-Inhibiting RELA/P65 and EGFR.
9292,32192,39490472,10.1016/j.ijbiomac.2024.136964,delivery,siRNA,PubMed abstract sentence 3,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Chitosan/siRNA nanoparticles targeting PARP-1 attenuate Neuroinflammation and apoptosis in hyperglycemia-induced oxidative stress in Neuro2a cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chitosan/siRNA nanoparticles targeting PARP-1 attenuate Neuroinflammation and apoptosis in hyperglycemia-induced oxidative stress in Neuro2a cells.
9308,32230,39388611,10.1021/acs.biochem.4c00327,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Delivery Aspects for Implementing siRNA Therapeutics for Blood Diseases.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery Aspects for Implementing siRNA Therapeutics for Blood Diseases.
9309,32231,39388611,10.1021/acs.biochem.4c00327,toxicity,siRNA,PubMed abstract sentence 1,adverse;hematological,"toxicity candidate; matched derived terms: adverse, hematological; source title: Delivery Aspects for Implementing siRNA Therapeutics for Blood Diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery Aspects for Implementing siRNA Therapeutics for Blood Diseases.
9310,32234,39387233,10.1080/17425247.2024.2409142,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development.
9314,32242,39378273,10.1021/acsami.4c10036,delivery,siRNA,PubMed abstract sentence 6,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Ultrasound-Responsive Nanocarriers Delivering siRNA and Fe(3)O(4) Nanoparticles Reprogram Macrophages and Inhibit M2 Polarization for Enhanced NSCLC Immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ultrasound-Responsive Nanocarriers Delivering siRNA and Fe(3)O(4) Nanoparticles Reprogram Macrophages and Inhibit M2 Polarization for Enhanced NSCLC Immunotherapy.
9316,32246,39375761,10.1186/s12951-024-02883-w,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Ultrasound-responsive nanocarriers with siRNA and Fe(3)O(4) regulate macrophage polarization and phagocytosis for augmented non-small cell lung cancer immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ultrasound-responsive nanocarriers with siRNA and Fe(3)O(4) regulate macrophage polarization and phagocytosis for augmented non-small cell lung cancer immunotherapy.
9317,32249,39359045,10.1002/smll.202405524,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Elucidating siRNA Cellular Delivery Mechanism Mediated by Quaternized Starch Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Elucidating siRNA Cellular Delivery Mechanism Mediated by Quaternized Starch Nanoparticles.
9319,32253,39329032,10.2147/IJN.S461167,delivery,ASO,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Ion Doped Hollow Silica Nanoparticles as Promising Oligonucleotide Delivery Systems to Mesenchymal Stem Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ion Doped Hollow Silica Nanoparticles as Promising Oligonucleotide Delivery Systems to Mesenchymal Stem Cells.
9320,32254,39329032,10.2147/IJN.S461167,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ion Doped Hollow Silica Nanoparticles as Promising Oligonucleotide Delivery Systems to Mesenchymal Stem Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Ion Doped Hollow Silica Nanoparticles as Promising Oligonucleotide Delivery Systems to Mesenchymal Stem Cells.
9322,32260,39323767,10.1039/d4pm00128a,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Tailoring lipid nanoparticle dimensions through manufacturing processes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tailoring lipid nanoparticle dimensions through manufacturing processes.
9323,32265,39301916,10.1002/advs.202406211,delivery,ASO/siRNA,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Lung-Targeted Lipid Nanoparticle-Delivered siUSP33 Attenuates SARS-CoV-2 Replication and Virulence by Promoting Envelope Degradation.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lung-Targeted Lipid Nanoparticle-Delivered siUSP33 Attenuates SARS-CoV-2 Replication and Virulence by Promoting Envelope Degradation.
9330,32280,39282740,10.1039/d4tb01433b,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: RNA-binding peptide and endosomal escape-assisting peptide (L2) improved siRNA delivery by the hexahistidine-metal assembly.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA-binding peptide and endosomal escape-assisting peptide (L2) improved siRNA delivery by the hexahistidine-metal assembly.
9331,32281,39282740,10.1039/d4tb01433b,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNA-binding peptide and endosomal escape-assisting peptide (L2) improved siRNA delivery by the hexahistidine-metal assembly.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA-binding peptide and endosomal escape-assisting peptide (L2) improved siRNA delivery by the hexahistidine-metal assembly.
9342,32308,39173936,10.1016/j.ejpb.2024.114468,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Synthesis of a novel adapter lipid using Fc-region mediated antibody modification for post-insert preparation of transferrin receptor targeted messenger RNA-loaded lipid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synthesis of a novel adapter lipid using Fc-region mediated antibody modification for post-insert preparation of transferrin receptor targeted messenger RNA-loaded lipid nanoparticles.
9350,32330,39099788,10.2147/IJN.S440419,toxicity,siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery of siRNAs Against Selective Ion Channels and Transporter Genes Using Hyaluronic Acid-coupled Carbonate Apatite Nanoparticles Synergistically Inhibits Growth and Survival of Breast Cancer Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery of siRNAs Against Selective Ion Channels and Transporter Genes Using Hyaluronic Acid-coupled Carbonate Apatite Nanoparticles Synergistically Inhibits Growth and Survival of Breast Cancer Cells.
9352,32334,39097115,10.1016/j.ejpb.2024.114432,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Therapeutic targeting of siRNA/anti-cancer drug delivery system for non-melanoma skin cancer. Part I: Development and gene silencing of JAK1siRNA/5-FU loaded liposome nanocomplexes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Therapeutic targeting of siRNA/anti-cancer drug delivery system for non-melanoma skin cancer. Part I: Development and gene silencing of JAK1siRNA/5-FU loaded liposome nanocomplexes.
9356,32344,39075467,10.1186/s12951-024-02733-9,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Rational design of ROS scavenging and fluorescent gold nanoparticles to deliver siRNA to improve plant resistance to Pseudomonas syringae.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rational design of ROS scavenging and fluorescent gold nanoparticles to deliver siRNA to improve plant resistance to Pseudomonas syringae.
9359,32349,39067551,10.1016/j.ijpharm.2024.124519,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;conjugated;lnp,"delivery candidate; matched derived terms: nanoparticle, conjugated, lnp; source title: DNA aptamer-conjugated lipid nanoparticle for targeted PTEN mRNA delivery to prostate cancer cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,DNA aptamer-conjugated lipid nanoparticle for targeted PTEN mRNA delivery to prostate cancer cells.
9361,32353,39067162,10.1016/j.biopha.2024.117108,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Advances in the development of lipid nanoparticles for ophthalmic therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in the development of lipid nanoparticles for ophthalmic therapeutics.
9364,32360,39062852,10.3390/ijms25147612,delivery,siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy.
9367,32367,39052313,10.1002/mabi.202400168,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Combinatorial Synthesis of Alkyl Chain-Capped Poly(β-Amino Ester)s for Effective siRNA Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Combinatorial Synthesis of Alkyl Chain-Capped Poly(β-Amino Ester)s for Effective siRNA Delivery.
9368,32370,39032575,10.1016/j.jconrel.2024.07.044,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Biofluid specific protein coronas affect lipid nanoparticle behavior in vitro.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Biofluid specific protein coronas affect lipid nanoparticle behavior in vitro.
9369,32373,39027257,10.1016/j.apsb.2024.03.004,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy.
9374,32386,38965378,10.1038/s41573-024-00977-6,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: The 60-year evolution of lipid nanoparticles for nucleic acid delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The 60-year evolution of lipid nanoparticles for nucleic acid delivery.
9380,32398,38933259,10.1016/j.omtn.2024.102224,chemistry,ASO/siRNA,PubMed abstract sentence 2,chemical;modification;lna,"chemistry candidate; matched derived terms: chemical, modification, lna; source title: Unlocking the therapeutic potential of locked nucleic acids through lipid nanoparticle delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unlocking the therapeutic potential of locked nucleic acids through lipid nanoparticle delivery.
9381,32399,38933259,10.1016/j.omtn.2024.102224,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Unlocking the therapeutic potential of locked nucleic acids through lipid nanoparticle delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unlocking the therapeutic potential of locked nucleic acids through lipid nanoparticle delivery.
9383,32403,38925059,10.1016/j.jcis.2024.06.158,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: The vast majority of nucleic acid-loaded lipid nanoparticles contain cargo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The vast majority of nucleic acid-loaded lipid nanoparticles contain cargo.
9384,32406,39492515,10.1016/j.jconrel.2023.10.035,delivery,siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Disease-specific corona mediated co-delivery of MTX and siRNA-TNFα by a polypeptide nanoplatform with antigen-scavenging functions in psoriasis.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Disease-specific corona mediated co-delivery of MTX and siRNA-TNFα by a polypeptide nanoplatform with antigen-scavenging functions in psoriasis.
9386,32410,37902726,10.1001/jamaneurol.2023.3861,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Exploratory Tau Biomarker Results From a Multiple Ascending-Dose Study of BIIB080 in Alzheimer Disease: A Randomized Clinical Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exploratory Tau Biomarker Results From a Multiple Ascending-Dose Study of BIIB080 in Alzheimer Disease: A Randomized Clinical Trial.
9389,32423,37638814,10.4155/bio-2023-0079,chemistry,siRNA,PubMed abstract sentence 3,lna;conjugate,"chemistry candidate; matched derived terms: lna, conjugate; source title: Evaluating the use of locked nucleic acid capture probes in hybrid LC-MS/MS analysis of siRNA analytes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluating the use of locked nucleic acid capture probes in hybrid LC-MS/MS analysis of siRNA analytes.
9391,32429,37578116,10.1021/acs.molpharmaceut.3c00206,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer.
9392,32436,37273265,10.1016/j.jsps.2023.05.017,delivery,siRNA,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: GL67 lipid-based liposomal formulation for efficient siRNA delivery into human lung cancer cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GL67 lipid-based liposomal formulation for efficient siRNA delivery into human lung cancer cells.
9394,32440,37205589,10.1101/2023.05.02.539140,chemistry,ASO,PubMed abstract sentence 1,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Syntheses of Pyrimidine-Modified Seleno-DNAs as Stable Antisense Molecules.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Syntheses of Pyrimidine-Modified Seleno-DNAs as Stable Antisense Molecules.
9396,32444,37110552,10.3390/molecules28083318,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Straightforward Method for the Development of Positively Charged Gold Nanoparticle-Based Vectors for Effective siRNA Delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Straightforward Method for the Development of Positively Charged Gold Nanoparticle-Based Vectors for Effective siRNA Delivery.
9398,32458,36972555,10.1002/adma.202211420,delivery,ASO/siRNA,PubMed abstract sentence 1,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Optimizing Lipid Nanoparticles for Delivery in Primates.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimizing Lipid Nanoparticles for Delivery in Primates.
9401,32465,36948476,10.1016/j.ijpharm.2023.122874,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticle formulations.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticle formulations.
9402,32466,36948476,10.1016/j.ijpharm.2023.122874,assay,ASO/siRNA,PubMed abstract sentence 3,screen;experiment,"assay candidate; matched derived terms: screen, experiment; source title: Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticle formulations.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticle formulations.
9405,32477,36755201,10.1002/advs.202300282,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Lymphocyte Membrane- and 12p1-Dual-Functionalized Nanoparticles for Free HIV-1 Trapping and Precise siRNA Delivery into HIV-1-Infected Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lymphocyte Membrane- and 12p1-Dual-Functionalized Nanoparticles for Free HIV-1 Trapping and Precise siRNA Delivery into HIV-1-Infected Cells.
9412,32492,36630075,10.1007/s13346-022-01281-9,delivery,siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Liposome-polyethylenimine complexes for the effective delivery of HuR siRNA in the treatment of diabetic retinopathy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Liposome-polyethylenimine complexes for the effective delivery of HuR siRNA in the treatment of diabetic retinopathy.
9413,32493,36630075,10.1007/s13346-022-01281-9,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Liposome-polyethylenimine complexes for the effective delivery of HuR siRNA in the treatment of diabetic retinopathy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Liposome-polyethylenimine complexes for the effective delivery of HuR siRNA in the treatment of diabetic retinopathy.
9416,32498,36541426,10.1002/biot.202200415,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Analysis of polymeric nanoparticle properties for siRNA/DNA delivery in a tumor xenograft tissue slice air-liquid interface model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Analysis of polymeric nanoparticle properties for siRNA/DNA delivery in a tumor xenograft tissue slice air-liquid interface model.
9422,32510,36697400,10.1080/17435390.2022.2159891,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Comparison of tyrosine-modified low molecular weight branched and linear polyethylenimines for siRNA delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comparison of tyrosine-modified low molecular weight branched and linear polyethylenimines for siRNA delivery.
9423,32515,36524967,10.1021/acsami.2c20019,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Mechanistic Insights into the Superior DNA Delivery Efficiency of Multicomponent Lipid Nanoparticles: An In Vitro and In Vivo Study.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mechanistic Insights into the Superior DNA Delivery Efficiency of Multicomponent Lipid Nanoparticles: An In Vitro and In Vivo Study.
9429,32531,36015328,10.3390/pharmaceutics14081698,delivery,ASO/siRNA,PubMed abstract sentence 6,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Efficient Delivery of DNA Using Lipid Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient Delivery of DNA Using Lipid Nanoparticles.
9430,32532,36015328,10.3390/pharmaceutics14081698,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Efficient Delivery of DNA Using Lipid Nanoparticles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficient Delivery of DNA Using Lipid Nanoparticles.
9431,32537,35992044,10.1016/j.omtn.2022.08.011,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: A model system for antiviral siRNA therapeutics using exosome-based delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A model system for antiviral siRNA therapeutics using exosome-based delivery.
9432,32538,35992044,10.1016/j.omtn.2022.08.011,assay,siRNA,PubMed abstract sentence 8,screen;model,"assay candidate; matched derived terms: screen, model; source title: A model system for antiviral siRNA therapeutics using exosome-based delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A model system for antiviral siRNA therapeutics using exosome-based delivery.
9435,32543,35819583,10.1007/s11095-022-03333-8,assay,siRNA,PubMed abstract sentence 5,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Pharmacokinetic and Pharmacodynamic Modeling of siRNA Therapeutics - a Minireview.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pharmacokinetic and Pharmacodynamic Modeling of siRNA Therapeutics - a Minireview.
9436,32544,35819583,10.1007/s11095-022-03333-8,benchmark,siRNA,PubMed abstract sentence 9,model;challenge,"benchmark candidate; matched derived terms: model, challenge; source title: Pharmacokinetic and Pharmacodynamic Modeling of siRNA Therapeutics - a Minireview.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pharmacokinetic and Pharmacodynamic Modeling of siRNA Therapeutics - a Minireview.
9438,32556,33992805,10.1016/j.ymthe.2021.05.004,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19.
9440,32564,33121373,10.1089/nat.2020.0893,delivery,siRNA,PubMed abstract sentence 5,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: To Conjugate or to Package? A Look at Targeted siRNA Delivery Through Folate Receptors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,To Conjugate or to Package? A Look at Targeted siRNA Delivery Through Folate Receptors.
9443,32569,33016168,10.1177/2472555220960045,offtarget,siRNA,PubMed abstract sentence 6,hybridization;silencing,"offtarget candidate; matched derived terms: hybridization, silencing; source title: An Automated High-Throughput Fluorescence In Situ Hybridization (FISH) Assay Platform for Use in the Identification and Optimization of siRNA-Based Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,An Automated High-Throughput Fluorescence In Situ Hybridization (FISH) Assay Platform for Use in the Identification and Optimization of siRNA-Based Therapeutics.
9447,32579,32678992,10.1089/nat.2020.0856,delivery,ASO,PubMed abstract sentence 13,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Approaches for Systemic Delivery of Dystrophin Antisense Peptide Nucleic Acid in the mdx Mouse Model.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Approaches for Systemic Delivery of Dystrophin Antisense Peptide Nucleic Acid in the mdx Mouse Model.
9454,32590,33143328,10.3390/pharmaceutics12111042,delivery,ASO/siRNA,PubMed abstract sentence 4,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aerosolizable Lipid Nanoparticles for Pulmonary Delivery of mRNA through Design of Experiments.
9456,32596,33119286,10.1021/acs.jmedchem.0c01407,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA.
9459,32601,32907491,10.1089/nat.2020.0870,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery of Antisense DNA into Pathogenic Parasite Trypanosoma cruzi Using Virus-Like Protein-Based Nanoparticles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Delivery of Antisense DNA into Pathogenic Parasite Trypanosoma cruzi Using Virus-Like Protein-Based Nanoparticles.
9462,32618,32622021,10.1016/j.addr.2020.06.026,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticle technology for therapeutic gene regulation in the liver.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticle technology for therapeutic gene regulation in the liver.
9466,32626,32529417,10.1007/s11095-020-02846-4,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhancement of Liposomal Plasmid DNA and siRNA Delivery by Itraconazole through Intracellular Cholesterol Accumulation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Enhancement of Liposomal Plasmid DNA and siRNA Delivery by Itraconazole through Intracellular Cholesterol Accumulation.
9467,32629,32366887,10.1038/s41434-020-0151-y,delivery,ASO,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Natural polyphenol assisted delivery of single-strand oligonucleotides by cationic polymers.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Natural polyphenol assisted delivery of single-strand oligonucleotides by cationic polymers.
9472,32642,32298783,10.1016/j.addr.2020.04.002,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes.
9475,32651,32175808,10.1089/nat.2020.0848,chemistry,siRNA,PubMed abstract sentence 7,chemical;modification;modified,"chemistry candidate; matched derived terms: chemical, modification, modified; source title: Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells.
9476,32656,31999380,10.1002/adma.201906128,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes.
9477,32657,31999380,10.1002/adma.201906128,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes.
9481,32667,31939190,10.1007/978-1-0716-0247-8_25,assay,ASO/siRNA,PubMed abstract sentence 5,screen;rna-seq,"assay candidate; matched derived terms: screen, rna-seq; source title: High-Throughput RNA Interference Screen Targeting Synthetic-Lethal Gain-of-Function of Oncogenic Mutant TP53 in Triple-Negative Breast Cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-Throughput RNA Interference Screen Targeting Synthetic-Lethal Gain-of-Function of Oncogenic Mutant TP53 in Triple-Negative Breast Cancer.
9482,32670,31718426,10.1089/nat.2019.0804,delivery,siRNA,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Endocytosis Controls siRNA Efficiency: Implications for siRNA Delivery Vehicle Design and Cell-Specific Targeting.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Endocytosis Controls siRNA Efficiency: Implications for siRNA Delivery Vehicle Design and Cell-Specific Targeting.
9484,32676,31666200,10.1016/j.nano.2019.102119,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration.
9487,32685,31763806,10.1021/acsami.9b17749,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Cell-Selective Messenger RNA Delivery and CRISPR/Cas9 Genome Editing by Modulating the Interface of Phenylboronic Acid-Derived Lipid Nanoparticles and Cellular Surface Sialic Acid.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cell-Selective Messenger RNA Delivery and CRISPR/Cas9 Genome Editing by Modulating the Interface of Phenylboronic Acid-Derived Lipid Nanoparticles and Cellular Surface Sialic Acid.
9492,32696,31410789,10.1007/978-1-4939-9670-4_2,delivery,ASO,PubMed abstract sentence 3,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Tissue-Specific Delivery of Oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tissue-Specific Delivery of Oligonucleotides.
9494,32700,31393218,10.1089/nat.2019.0782,chemistry,siRNA,PubMed abstract sentence 1,galnac;lna;conjugate,"chemistry candidate; matched derived terms: galnac, lna, conjugate; source title: Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing.
9495,32701,31393218,10.1089/nat.2019.0782,delivery,siRNA,PubMed abstract sentence 1,galnac;conjugated,"delivery candidate; matched derived terms: galnac, conjugated; source title: Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing.
9497,32705,31381852,10.1021/acs.nanolett.9b01660,delivery,siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Stimuli-Responsive Polymer-Prodrug Hybrid Nanoplatform for Multistage siRNA Delivery and Combination Cancer Therapy.",C,high_candidate,curator_verified,accept,derived_annotations_only,Stimuli-Responsive Polymer-Prodrug Hybrid Nanoplatform for Multistage siRNA Delivery and Combination Cancer Therapy.
9501,32715,31140918,10.1089/nat.2019.0784,delivery,siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Formulation of Biocompatible Targeted ECO/siRNA Nanoparticles with Long-Term Stability for Clinical Translation of RNAi.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Formulation of Biocompatible Targeted ECO/siRNA Nanoparticles with Long-Term Stability for Clinical Translation of RNAi.
9506,32726,30986436,10.1016/j.jconrel.2019.04.015,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid nanoparticles for delivery of messenger RNA to the back of the eye.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid nanoparticles for delivery of messenger RNA to the back of the eye.
9507,32727,30986436,10.1016/j.jconrel.2019.04.015,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid nanoparticles for delivery of messenger RNA to the back of the eye.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid nanoparticles for delivery of messenger RNA to the back of the eye.
9508,32730,30940496,10.1016/j.jconrel.2019.03.028,chemistry,siRNA,PubMed abstract sentence 4,chemical;conjugate,"chemistry candidate; matched derived terms: chemical, conjugate; source title: The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo."
9514,32746,30637934,10.1002/smll.201805097,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH.
9518,32754,30544191,10.1093/nar/gky1239,chemistry,siRNA,PubMed abstract sentence 8,chemical;conjugate,"chemistry candidate; matched derived terms: chemical, conjugate; source title: Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.
9521,32759,30535404,10.1093/nar/gky1232,chemistry,siRNA,PubMed abstract sentence 7,modification;phosphorothioate,"chemistry candidate; matched derived terms: modification, phosphorothioate; source title: Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
9522,32760,30535404,10.1093/nar/gky1232,delivery,siRNA,PubMed abstract sentence 8,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
9528,32774,30143435,10.1016/j.ymthe.2018.08.005,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
9534,32788,29937418,10.1016/j.ymthe.2018.05.024,chemistry,siRNA,PubMed abstract sentence 5,chemical;modification;modified;conjugate,"chemistry candidate; matched derived terms: chemical, modification, modified, conjugate; source title: Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.
9539,32799,29797261,10.1007/978-1-4939-7865-6_14,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Microfluidic Production and Application of Lipid Nanoparticles for Nucleic Acid Transfection.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Microfluidic Production and Application of Lipid Nanoparticles for Nucleic Acid Transfection.
9542,32808,29727206,10.1080/17425247.2018.1473375,chemistry,ASO,PubMed abstract sentence 7,chemical;modification;conjugate,"chemistry candidate; matched derived terms: chemical, modification, conjugate; source title: Recent preclinical and clinical advances in oligonucleotide conjugates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent preclinical and clinical advances in oligonucleotide conjugates.
9546,32816,29699940,10.1016/j.ymthe.2018.03.019,delivery,siRNA,PubMed abstract sentence 5,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles.
9547,32819,29683383,10.1089/nat.2018.0721,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility.
9550,32824,29584585,10.1089/nat.2017.0715,assay,siRNA,PubMed abstract sentence 5,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Journey of siRNA: Clinical Developments and Targeted Delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Journey of siRNA: Clinical Developments and Targeted Delivery.
9554,32832,29432571,10.1093/nar/gky037,chemistry,siRNA,PubMed abstract sentence 4,chemical;modified;conjugate,"chemistry candidate; matched derived terms: chemical, modified, conjugate; source title: Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.",B,high_candidate,curator_verified,accept,derived_annotations_only,Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
9561,32849,29121767,10.1021/acs.molpharmaceut.7b00725,delivery,siRNA,PubMed abstract sentence 2,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery."
9562,32850,29121767,10.1021/acs.molpharmaceut.7b00725,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery."
9563,32853,29022758,10.1089/nat.2017.0690,chemistry,ASO,PubMed abstract sentence 9,chemical;modified;conjugate,"chemistry candidate; matched derived terms: chemical, modified, conjugate; source title: Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.
9570,32866,28836442,10.1021/acs.nanolett.7b02664,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA.
9571,32867,28836442,10.1021/acs.nanolett.7b02664,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA.
9572,32872,28727419,10.1021/acsnano.7b04734,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Next-Generation Lipids in RNA Interference Therapeutics.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Next-Generation Lipids in RNA Interference Therapeutics.
9577,32887,28591791,10.1093/nar/gkx507,chemistry,siRNA,PubMed abstract sentence 4,chemical;modification;conjugate,"chemistry candidate; matched derived terms: chemical, modification, conjugate; source title: 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.",B,high_candidate,curator_verified,accept,derived_annotations_only,5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
9578,32888,28591791,10.1093/nar/gkx507,delivery,siRNA,PubMed abstract sentence 4,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
9581,32897,28324594,10.1007/s41061-017-0127-6,delivery,siRNA,PubMed abstract sentence 10,delivery;nanoparticle;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, uptake; source title: Polymers in the Delivery of siRNA for the Treatment of Virus Infections.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Polymers in the Delivery of siRNA for the Treatment of Virus Infections.
9583,32901,28244990,10.1038/nbt.3765,chemistry,ASO,PubMed abstract sentence 4,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: The chemical evolution of oligonucleotide therapies of clinical utility.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The chemical evolution of oligonucleotide therapies of clinical utility.
9592,32918,27974266,10.1016/j.biomaterials.2016.12.001,delivery,siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors.
9594,32922,27899655,10.1093/nar/gkw1005,chemistry,siRNA,PubMed abstract sentence 3,chemical;modified,"chemistry candidate; matched derived terms: chemical, modified; source title: Visualization of self-delivering hydrophobically modified siRNA cellular internalization.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Visualization of self-delivering hydrophobically modified siRNA cellular internalization.
9597,32931,27890901,10.5582/ddt.2016.01070,delivery,ASO,PubMed abstract sentence 2,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Can colorectal delivery technology provide a platform for enteral oligonucleotide-based therapeutics?",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Can colorectal delivery technology provide a platform for enteral oligonucleotide-based therapeutics?
9599,32935,27711272,10.1039/c6cc06024b,delivery,siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Intercalation-mediated nucleic acid nanoparticles for siRNA delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intercalation-mediated nucleic acid nanoparticles for siRNA delivery.
9601,32939,27629437,10.1089/nat.2016.0631,chemistry,ASO,PubMed abstract sentence 5,phosphorothioate;2'-o,"chemistry candidate; matched derived terms: phosphorothioate, 2'-o; source title: Four Novel Splice-Switch Reporter Cell Lines: Distinct Impact of Oligonucleotide Chemistry and Delivery Vector on Biological Activity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Four Novel Splice-Switch Reporter Cell Lines: Distinct Impact of Oligonucleotide Chemistry and Delivery Vector on Biological Activity.
9602,32940,27629437,10.1089/nat.2016.0631,delivery,ASO,PubMed abstract sentence 6,delivery;nanoparticle;uptake,"delivery candidate; matched derived terms: delivery, nanoparticle, uptake; source title: Four Novel Splice-Switch Reporter Cell Lines: Distinct Impact of Oligonucleotide Chemistry and Delivery Vector on Biological Activity.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Four Novel Splice-Switch Reporter Cell Lines: Distinct Impact of Oligonucleotide Chemistry and Delivery Vector on Biological Activity.
9606,32948,27588674,10.1080/1061186X.2016.1221955,delivery,siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Pieter Cullis' quest for a lipid-based, fusogenic delivery system for nucleic acid therapeutics: success with siRNA so what about mRNA?",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Pieter Cullis' quest for a lipid-based, fusogenic delivery system for nucleic acid therapeutics: success with siRNA so what about mRNA?"
9614,32964,27483025,10.1038/mtna.2016.55,chemistry,siRNA,PubMed abstract sentence 5,chemical;modified;conjugate,"chemistry candidate; matched derived terms: chemical, modified, conjugate; source title: Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.
9615,32965,27483025,10.1038/mtna.2016.55,delivery,siRNA,PubMed abstract sentence 5,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.
9621,32979,27084936,10.1093/nar/gkw236,delivery,ASO,PubMed abstract sentence 3,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: The delivery of therapeutic oligonucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The delivery of therapeutic oligonucleotides.
9626,32994,36775056,10.1016/j.gpb.2023.01.006,assay,ASO/siRNA,PubMed abstract sentence 6,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Preclinical-to-clinical Anti-cancer Drug Response Prediction and Biomarker Identification Using TINDL.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical-to-clinical Anti-cancer Drug Response Prediction and Biomarker Identification Using TINDL.
9627,32995,36775056,10.1016/j.gpb.2023.01.006,benchmark,ASO/siRNA,PubMed abstract sentence 5,database;model,"benchmark candidate; matched derived terms: database, model; source title: Preclinical-to-clinical Anti-cancer Drug Response Prediction and Biomarker Identification Using TINDL.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical-to-clinical Anti-cancer Drug Response Prediction and Biomarker Identification Using TINDL.
9629,32999,33104800,10.1093/nar/gkaa936,benchmark,siRNA,PubMed abstract sentence 2,database;model,"benchmark candidate; matched derived terms: database, model; source title: FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update.
9632,33034,41815811,10.4103/bc.bc_65_24,assay,ASO/siRNA,PubMed abstract sentence 9,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: A novel mucosa-associated lymphoid tissue translocation gene 1-related immune prognostic signature and targeted drug screening for glioblastoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A novel mucosa-associated lymphoid tissue translocation gene 1-related immune prognostic signature and targeted drug screening for glioblastoma.
9648,33128,41780910,10.1093/eurheartj/ehag147,assay,ASO/siRNA,PubMed abstract sentence 5,model;trial,"assay candidate; matched derived terms: model, trial; source title: Breast tumour-secreted ADAM10 mediates atrial fibrogenesis and fibrillation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Breast tumour-secreted ADAM10 mediates atrial fibrogenesis and fibrillation.
9669,33305,41707840,10.1016/j.micpath.2026.108386,assay,ASO/siRNA,PubMed abstract sentence 16,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: Screening and functional validation of host interacting proteins for the key invasion protein LRR5 of Mycoplasma bovis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Screening and functional validation of host interacting proteins for the key invasion protein LRR5 of Mycoplasma bovis.
9670,33308,41707378,10.1016/j.bbrc.2026.153428,assay,ASO/siRNA,PubMed abstract sentence 2,assay;model,"assay candidate; matched derived terms: assay, model; source title: Mapping metastatic potential through cytoskeletal remodeling: A mechanobiology-based multi-cancer analysis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mapping metastatic potential through cytoskeletal remodeling: A mechanobiology-based multi-cancer analysis.
9781,33923,40371106,10.3389/fmicb.2025.1563240,chemistry,ASO/siRNA,PubMed abstract sentence 4,modification;modified,"chemistry candidate; matched derived terms: modification, modified; source title: MeRIP-Seq initially revealed the role of m6A modification in Chinese sacbrood virus-infected Apis cerana larvae.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MeRIP-Seq initially revealed the role of m6A modification in Chinese sacbrood virus-infected Apis cerana larvae.
9788,33970,40342110,10.15586/aei.v53i3.1225,assay,ASO/siRNA,PubMed abstract sentence 4,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Knockdown of THBS1 inhibits inflammatory damage and oxidative stress in in vitro pneumonia model by regulating NF-κB signaling pathway.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Knockdown of THBS1 inhibits inflammatory damage and oxidative stress in in vitro pneumonia model by regulating NF-κB signaling pathway.
9840,34226,40186485,10.1093/europace/euaf081,assay,ASO/siRNA,PubMed abstract sentence 5,model;trial,"assay candidate; matched derived terms: model, trial; source title: Mitochondrial damage mediates STING activation driving obesity-mediated atrial fibrillation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mitochondrial damage mediates STING activation driving obesity-mediated atrial fibrillation.
9843,34233,40178289,10.1002/advs.202412356,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases.
9852,34310,40139331,10.1016/j.bmcl.2025.130208,chemistry,ASO,PubMed abstract sentence 2,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: PEG-ASO conjugates for efficient targeted delivery and migration inhibition in Cancer cell.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,PEG-ASO conjugates for efficient targeted delivery and migration inhibition in Cancer cell.
9853,34311,40139331,10.1016/j.bmcl.2025.130208,delivery,ASO,PubMed abstract sentence 3,conjugated;uptake,"delivery candidate; matched derived terms: conjugated, uptake; source title: PEG-ASO conjugates for efficient targeted delivery and migration inhibition in Cancer cell.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,PEG-ASO conjugates for efficient targeted delivery and migration inhibition in Cancer cell.
9887,34527,40025506,10.1186/s13287-025-04245-1,assay,ASO/siRNA,PubMed abstract sentence 6,assay;model,"assay candidate; matched derived terms: assay, model; source title: Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Apoptotic vesicles derived from bone marrow mesenchymal stem cells increase angiogenesis in a hind limb ischemia model via the NAMPT/SIRT1/FOXO1 axis.
9901,34593,40004122,10.3390/ijms26041658,assay,ASO/siRNA,PubMed abstract sentence 6,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Clinical Proof-of-Concept of a Non-Gene Editing Technology Using miRNA-Based shRNA to Engineer Allogeneic CAR T-Cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clinical Proof-of-Concept of a Non-Gene Editing Technology Using miRNA-Based shRNA to Engineer Allogeneic CAR T-Cells.
9925,34719,39954140,10.1007/s00604-025-07016-0,chemistry,ASO/siRNA,PubMed abstract sentence 5,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Highly sensitive label-free photoelectrochemical aptasensor based on Cu(2)MoS(4)@Ti(3)C(2)T(x) MXene heterojunction for tetracycline detection in milk.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Highly sensitive label-free photoelectrochemical aptasensor based on Cu(2)MoS(4)@Ti(3)C(2)T(x) MXene heterojunction for tetracycline detection in milk.
9933,34775,39937508,10.1001/jamacardio.2024.5433,assay,ASO/siRNA,PubMed abstract sentence 6,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Olpasiran, Oxidized Phospholipids, and Systemic Inflammatory Biomarkers: Results From the OCEAN(a)-DOSE Trial.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Olpasiran, Oxidized Phospholipids, and Systemic Inflammatory Biomarkers: Results From the OCEAN(a)-DOSE Trial."
9948,34838,39892108,10.1016/j.vaccine.2025.126787,assay,ASO/siRNA,PubMed abstract sentence 3,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: A phase I/II study of CpG/alum-adjuvanted mammalian-derived quadruple antigen carrying virus-like particle COVID-19 vaccine.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A phase I/II study of CpG/alum-adjuvanted mammalian-derived quadruple antigen carrying virus-like particle COVID-19 vaccine.
9963,34923,39837902,10.1038/s41597-025-04411-3,benchmark,ASO/siRNA,PubMed abstract sentence 7,prediction;dataset,"benchmark candidate; matched derived terms: prediction, dataset; source title: Comprehensive genome annotation of Trilocha varians, a new model species of Lepidopteran insects.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Comprehensive genome annotation of Trilocha varians, a new model species of Lepidopteran insects."
9967,34945,39828065,10.1016/j.gene.2025.149258,assay,ASO/siRNA,PubMed abstract sentence 3,assay;model;experiment,"assay candidate; matched derived terms: assay, model, experiment; source title: ZNF703 promotes Triple-Negative breast cancer cell progression and in combination with STK11 predicts disease recurrence (ZS -TNBC Model).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,ZNF703 promotes Triple-Negative breast cancer cell progression and in combination with STK11 predicts disease recurrence (ZS -TNBC Model).
9969,34951,39826521,10.1016/j.foodchem.2025.142914,chemistry,ASO/siRNA,PubMed abstract sentence 3,chemical;conjugate,"chemistry candidate; matched derived terms: chemical, conjugate; source title: Chemically reduced graphene oxide based assembly of Aptasensor for sensitive and probe-free detection of penicillin-G.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemically reduced graphene oxide based assembly of Aptasensor for sensitive and probe-free detection of penicillin-G.
9975,34981,39815992,10.1089/ars.2024.0670,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ALOX15 Aggravates Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice with Type 2 Diabetes via Activating the PPARγ/CD36 Axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ALOX15 Aggravates Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice with Type 2 Diabetes via Activating the PPARγ/CD36 Axis.
10012,35158,39637936,10.1016/j.jip.2024.108239,toxicity,ASO/siRNA,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sequence independent immune effects of white spot syndrome virus (WSSV) dsRNA complexed with phytoglycogen nanoparticles in freshwater crayfish.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Sequence independent immune effects of white spot syndrome virus (WSSV) dsRNA complexed with phytoglycogen nanoparticles in freshwater crayfish.
10017,35177,39603198,10.1016/j.colsurfb.2024.114386,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Interfacial interactions between DNA and polysaccharide-coated magnetic nanoparticles: Insight from simulations and experiments.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Interfacial interactions between DNA and polysaccharide-coated magnetic nanoparticles: Insight from simulations and experiments.
10018,35180,39601974,10.1007/s12010-024-05091-2,chemistry,ASO/siRNA,PubMed abstract sentence 6,chemical;conjugate,"chemistry candidate; matched derived terms: chemical, conjugate; source title: Comparative Analysis of Aptamer-Conjugated Chemical and Green Synthesized Gold Nanoparticles for Targeted Therapy in MCF-7 Cancer Cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comparative Analysis of Aptamer-Conjugated Chemical and Green Synthesized Gold Nanoparticles for Targeted Therapy in MCF-7 Cancer Cells.
10019,35181,39601974,10.1007/s12010-024-05091-2,delivery,ASO/siRNA,PubMed abstract sentence 6,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: Comparative Analysis of Aptamer-Conjugated Chemical and Green Synthesized Gold Nanoparticles for Targeted Therapy in MCF-7 Cancer Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comparative Analysis of Aptamer-Conjugated Chemical and Green Synthesized Gold Nanoparticles for Targeted Therapy in MCF-7 Cancer Cells.
10025,35223,39549731,10.1016/j.jconrel.2024.11.025,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: DNA tetrahedral nanoparticles: Co-delivery of siOTUD6B/DOX against triple-negative breast cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,DNA tetrahedral nanoparticles: Co-delivery of siOTUD6B/DOX against triple-negative breast cancer.
10029,35233,39533498,10.1002/adhm.202400510,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Low Molecular Weight Alginate Oligosaccharides as Alternatives to PEG for Enhancement of the Diffusion of Cationic Nanoparticles Through Cystic Fibrosis Mucus.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Low Molecular Weight Alginate Oligosaccharides as Alternatives to PEG for Enhancement of the Diffusion of Cationic Nanoparticles Through Cystic Fibrosis Mucus.
10039,35283,39419722,10.1016/j.hbpd.2024.09.010,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Cisplatin induces acute liver injury by triggering caspase-3/GSDME-mediated cell pyroptosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cisplatin induces acute liver injury by triggering caspase-3/GSDME-mediated cell pyroptosis.
10068,35422,39642313,10.1021/acs.jafc.4c09143,assay,ASO/siRNA,PubMed abstract sentence 3,model;experiment,"assay candidate; matched derived terms: model, experiment; source title: Rutin Attenuates the Oxidative Damage Induced by Zearalenone in Piglet Endometrial Stromal Cells via the p53 Signaling Pathway.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rutin Attenuates the Oxidative Damage Induced by Zearalenone in Piglet Endometrial Stromal Cells via the p53 Signaling Pathway.
10076,35472,39579302,10.1186/s11671-024-04148-9,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nucleus-targeted Silencer nanoplatform regulating ZEB1-AS1 in head and neck squamous cell carcinoma therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nucleus-targeted Silencer nanoplatform regulating ZEB1-AS1 in head and neck squamous cell carcinoma therapy.
10077,35479,39570470,10.1007/s11011-024-01471-z,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticles (NPs)-meditated si-lncRNA NONHSAT159592.1 inhibits glioblastoma progression and invasion through targeting the ITGA3/FAK/PI3K/AKT pathway.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticles (NPs)-meditated si-lncRNA NONHSAT159592.1 inhibits glioblastoma progression and invasion through targeting the ITGA3/FAK/PI3K/AKT pathway.
10079,35491,39543727,10.1186/s12967-024-05837-w,delivery,ASO/siRNA,PubMed abstract sentence 10,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: DNA tetrahedron nanoparticles service as a help carrier and adjvant of mRNA vaccine.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,DNA tetrahedron nanoparticles service as a help carrier and adjvant of mRNA vaccine.
10080,35494,39542300,10.1016/j.ijbiomac.2024.137582,delivery,ASO/siRNA,PubMed abstract sentence 7,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Utilizing ionic liquids as eco-friendly and sustainable carriers for delivering nucleic acids: A review on the revolutionary advancement in nano delivery systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Utilizing ionic liquids as eco-friendly and sustainable carriers for delivering nucleic acids: A review on the revolutionary advancement in nano delivery systems.
10085,35505,39533430,10.1186/s12951-024-02943-1,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization.
10086,35514,39521158,10.1016/j.ijpharm.2024.124928,delivery,ASO/siRNA,PubMed abstract sentence 7,nanoparticle;uptake,"delivery candidate; matched derived terms: nanoparticle, uptake; source title: Cysteamine functionalized gold nanoparticles exhibit high efficiency delivery of genetic materials in embryonic stem cells majorly via clathrin mediated endocytosis.",C,high_candidate,curator_verified,accept,derived_annotations_only,Cysteamine functionalized gold nanoparticles exhibit high efficiency delivery of genetic materials in embryonic stem cells majorly via clathrin mediated endocytosis.
10087,35515,39521158,10.1016/j.ijpharm.2024.124928,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cysteamine functionalized gold nanoparticles exhibit high efficiency delivery of genetic materials in embryonic stem cells majorly via clathrin mediated endocytosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cysteamine functionalized gold nanoparticles exhibit high efficiency delivery of genetic materials in embryonic stem cells majorly via clathrin mediated endocytosis.
10091,35529,39509143,10.1021/acsami.4c15099,delivery,ASO/siRNA,PubMed abstract sentence 4,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Stem Cell Membrane-Camouflaged Biomimetic Nanoparticles Inhibiting Leptin Pathway for Intervertebral Disc Degeneration Therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Stem Cell Membrane-Camouflaged Biomimetic Nanoparticles Inhibiting Leptin Pathway for Intervertebral Disc Degeneration Therapy.
10095,35553,39466232,10.1021/acs.biomac.4c00954,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Efficient Polymeric Nanoparticle Gene Delivery Enabled Via Tri- and Tetrafunctional Branching.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient Polymeric Nanoparticle Gene Delivery Enabled Via Tri- and Tetrafunctional Branching.
10103,35581,39437969,10.1016/j.jconrel.2024.10.044,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Hepatic stellate cell-targeted chemo-gene therapy for liver fibrosis using fluorinated peptide-lipid hybrid nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hepatic stellate cell-targeted chemo-gene therapy for liver fibrosis using fluorinated peptide-lipid hybrid nanoparticles.
10108,35596,39427007,10.1038/s41598-024-75042-8,assay,ASO/siRNA,PubMed abstract sentence 9,assay;experiment,"assay candidate; matched derived terms: assay, experiment; source title: Enhanced docetaxel therapeutic effect using dual targeted SRL-2 and TA1 aptamer conjugated micelles in inhibition Balb/c mice breast cancer model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced docetaxel therapeutic effect using dual targeted SRL-2 and TA1 aptamer conjugated micelles in inhibition Balb/c mice breast cancer model.
10119,35639,39363882,10.1016/j.omtn.2024.102322,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Highly efficient nucleic acid encapsulation method for targeted gene therapy using antibody conjugation system.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Highly efficient nucleic acid encapsulation method for targeted gene therapy using antibody conjugation system.
10120,35642,39363829,10.1039/d4nr02692f,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: CD56-targeted in vivo genetic engineering of natural killer cells mediates immunotherapy for acute myeloid leukemia.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CD56-targeted in vivo genetic engineering of natural killer cells mediates immunotherapy for acute myeloid leukemia.
10133,35717,39284017,10.1021/acsami.4c12721,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Local mRNA Delivery from Nanocomposites Made of Gelatin and Hydroxyapatite Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Local mRNA Delivery from Nanocomposites Made of Gelatin and Hydroxyapatite Nanoparticles.
10135,35723,39281702,10.1016/j.omtn.2024.102313,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle;lnp,"delivery candidate; matched derived terms: delivery, nanoparticle, lnp; source title: Advancements and challenges in mRNA and ribonucleoprotein-based therapies: From delivery systems to clinical applications.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advancements and challenges in mRNA and ribonucleoprotein-based therapies: From delivery systems to clinical applications.
10139,35739,39263661,10.1039/d4sc03666b,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Covalent recruitment of polymers and nanoparticles onto glycan-engineered cells enhances gene delivery during short exposure.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Covalent recruitment of polymers and nanoparticles onto glycan-engineered cells enhances gene delivery during short exposure.
10142,35748,39258393,10.1002/adhm.202402688,delivery,ASO/siRNA,PubMed abstract sentence 3,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: PEI-Engineered Lipid@PLGA Hybrid Nanoparticles for Multimodal Delivery of Antigens and Immune Adjuvants to the Respiratory Mucosa.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,PEI-Engineered Lipid@PLGA Hybrid Nanoparticles for Multimodal Delivery of Antigens and Immune Adjuvants to the Respiratory Mucosa.
10145,35757,39246424,10.2147/IJN.S472276,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hybrid Liposome-MSN System with Co-Delivering Potential Effective Against Multidrug-Resistant Tumor Targets in Mice Model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hybrid Liposome-MSN System with Co-Delivering Potential Effective Against Multidrug-Resistant Tumor Targets in Mice Model.
10152,35780,39223270,10.1038/s41563-024-01961-6,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery.
10162,35814,39185801,10.1021/acs.biomac.4c00165,delivery,ASO/siRNA,PubMed abstract sentence 9,delivery;route,"delivery candidate; matched derived terms: delivery, route; source title: Development of an Elastin-like Polypeptide-Based Nucleic Acid Delivery System Targeted to EGFR+ Bladder Cancer Cells Using a Layer-by-Layer Approach.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development of an Elastin-like Polypeptide-Based Nucleic Acid Delivery System Targeted to EGFR+ Bladder Cancer Cells Using a Layer-by-Layer Approach.
10166,35826,39177875,10.1007/s40259-024-00674-1,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Systematic Review of Genetic Substrate Reduction Therapy in Lysosomal Storage Diseases: Opportunities, Challenges and Delivery Systems.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Systematic Review of Genetic Substrate Reduction Therapy in Lysosomal Storage Diseases: Opportunities, Challenges and Delivery Systems."
10168,35830,39177133,10.2174/0109298665310091240809103048,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Macromolecular Polymer Based Complexes: A Diverse Strategy for the Delivery of Nucleotides.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Macromolecular Polymer Based Complexes: A Diverse Strategy for the Delivery of Nucleotides.
10173,35853,39148942,10.3389/fbioe.2024.1415191,toxicity,ASO/siRNA,PubMed abstract sentence 17,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Dendritic polylysine co-delivery of paclitaxel and siAXL enhances the sensitivity of triple-negative breast cancer chemotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dendritic polylysine co-delivery of paclitaxel and siAXL enhances the sensitivity of triple-negative breast cancer chemotherapy.
10174,35858,39143861,10.1002/cbic.202400451,chemistry,ASO/siRNA,PubMed abstract sentence 2,lna;conjugate,"chemistry candidate; matched derived terms: lna, conjugate; source title: Adsorption and Distribution of Triplex-Hybridizing Bioconjugated Gold Nanoclusters Inside Spermatozoa- A Study Using Confocal Microscopy and Fluorescence Lifetime Imaging.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Adsorption and Distribution of Triplex-Hybridizing Bioconjugated Gold Nanoclusters Inside Spermatozoa- A Study Using Confocal Microscopy and Fluorescence Lifetime Imaging.
10179,35873,39139640,10.3389/fphar.2024.1437071,delivery,ASO/siRNA,PubMed abstract sentence 5,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Nanoparticles (NPs)-mediated lncMALAT1 silencing to reverse cisplatin resistance for effective hepatocellular carcinoma therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nanoparticles (NPs)-mediated lncMALAT1 silencing to reverse cisplatin resistance for effective hepatocellular carcinoma therapy.
10195,35947,39067914,10.1016/j.aca.2024.342922,assay,ASO/siRNA,PubMed abstract sentence 4,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: Combination of Capture-SELEX and Post-SELEX for procymidone-specific aptamer selection and broad-specificity aptamer discovery, and development of aptamer-based lateral flow assay.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Combination of Capture-SELEX and Post-SELEX for procymidone-specific aptamer selection and broad-specificity aptamer discovery, and development of aptamer-based lateral flow assay."
10200,35960,39052238,10.1039/d4nr01955e,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Membrane-localized magnetic hyperthermia promotes intracellular delivery of cell-impermeant probes.
10203,35967,39044710,10.2174/1574892818666230419081414,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Co-delivery of Siape1 and Melatonin by (125)I-loaded PSMA-targeted Nanoparticles for the Treatment of Prostate Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Co-delivery of Siape1 and Melatonin by (125)I-loaded PSMA-targeted Nanoparticles for the Treatment of Prostate Cancer.
10204,35972,39031853,10.1002/smll.202401776,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Metal-Phenolic Network-Enabled Nanoadjuvant to Modulate Immune Responses.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Metal-Phenolic Network-Enabled Nanoadjuvant to Modulate Immune Responses.
10209,35985,38994035,10.7150/thno.95423,delivery,ASO,PubMed abstract sentence 5,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Osteoblast-specific down-regulation of NLRP3 inflammasome by aptamer-functionalized liposome nanoparticles improves bone quality in postmenopausal osteoporosis rats.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Osteoblast-specific down-regulation of NLRP3 inflammasome by aptamer-functionalized liposome nanoparticles improves bone quality in postmenopausal osteoporosis rats.
10210,35988,38990678,10.1021/acsami.4c08302,assay,ASO/siRNA,PubMed abstract sentence 8,assay;model,"assay candidate; matched derived terms: assay, model; source title: Ultrasensitive Electrochemiluminescence Biosensing Platform Based on Polymer Dots with Aggregation-Induced Emission for Dual-Biotoxin Assay.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ultrasensitive Electrochemiluminescence Biosensing Platform Based on Polymer Dots with Aggregation-Induced Emission for Dual-Biotoxin Assay.
10215,36001,38951806,10.1186/s12951-024-02648-5,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Recent advances in gene delivery nanoplatforms based on spherical nucleic acids.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Recent advances in gene delivery nanoplatforms based on spherical nucleic acids.
10221,36029,38907920,10.1007/978-1-0716-3918-4_14,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Fluorescent Techniques for RNA Detection in Nanoparticles.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Fluorescent Techniques for RNA Detection in Nanoparticles.
10225,36039,38898204,10.1208/s12249-024-02858-y,delivery,ASO/siRNA,PubMed abstract sentence 2,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Development, Optimization, and in vitro Evaluation of Silybin-loaded PLGA Nanoparticles and Decoration with 5TR1 Aptamer for Targeted Delivery to Colorectal Cancer Cells.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Development, Optimization, and in vitro Evaluation of Silybin-loaded PLGA Nanoparticles and Decoration with 5TR1 Aptamer for Targeted Delivery to Colorectal Cancer Cells."
10226,36040,38898204,10.1208/s12249-024-02858-y,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development, Optimization, and in vitro Evaluation of Silybin-loaded PLGA Nanoparticles and Decoration with 5TR1 Aptamer for Targeted Delivery to Colorectal Cancer Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Development, Optimization, and in vitro Evaluation of Silybin-loaded PLGA Nanoparticles and Decoration with 5TR1 Aptamer for Targeted Delivery to Colorectal Cancer Cells."
10232,36082,37843918,10.1080/08982104.2023.2271046,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;conjugated,"delivery candidate; matched derived terms: delivery, conjugated; source title: AS1411aptamer conjugated liposomes for targeted delivery of arsenic trioxide in mouse xenograft model of melanoma cancer.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,AS1411aptamer conjugated liposomes for targeted delivery of arsenic trioxide in mouse xenograft model of melanoma cancer.
10234,36084,37843918,10.1080/08982104.2023.2271046,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: AS1411aptamer conjugated liposomes for targeted delivery of arsenic trioxide in mouse xenograft model of melanoma cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,AS1411aptamer conjugated liposomes for targeted delivery of arsenic trioxide in mouse xenograft model of melanoma cancer.
10239,36107,37672983,10.1016/j.talanta.2023.125107,assay,ASO/siRNA,PubMed abstract sentence 3,assay;model;phase,"assay candidate; matched derived terms: assay, model, phase; source title: Iodinated organic molecule as tag for inductively coupled Plasma-mass spectrometry aptamer assays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Iodinated organic molecule as tag for inductively coupled Plasma-mass spectrometry aptamer assays.
10240,36116,37527031,10.1002/art.42665,assay,ASO/siRNA,PubMed abstract sentence 2,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Liposomal AntagomiR-155-5p Restores Anti-Inflammatory Macrophages and Improves Arthritis in Preclinical Models of Rheumatoid Arthritis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Liposomal AntagomiR-155-5p Restores Anti-Inflammatory Macrophages and Improves Arthritis in Preclinical Models of Rheumatoid Arthritis.
10254,36172,37823252,10.1039/d3nr02635c,delivery,ASO/siRNA,PubMed abstract sentence 3,nanoparticle;conjugated,"delivery candidate; matched derived terms: nanoparticle, conjugated; source title: A rapid total bacterial count method using gold nanoparticles conjugated with an aptamer for water quality assessment.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A rapid total bacterial count method using gold nanoparticles conjugated with an aptamer for water quality assessment.
10255,36175,37802125,10.1021/acs.accounts.3c00394,delivery,ASO/siRNA,PubMed abstract sentence 12,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: Engineering and Delivery of cGAS-STING Immunomodulators for the Immunotherapy of Cancer and Autoimmune Diseases.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineering and Delivery of cGAS-STING Immunomodulators for the Immunotherapy of Cancer and Autoimmune Diseases.
10268,36246,37650117,10.1016/j.omtn.2023.07.035,chemistry,ASO/siRNA,PubMed abstract sentence 5,modification;modified,"chemistry candidate; matched derived terms: modification, modified; source title: Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA.
10269,36249,37643976,10.3724/zdxbyxb-2023-0130,chemistry,ASO/siRNA,PubMed abstract sentence 4,chemical;modification,"chemistry candidate; matched derived terms: chemical, modification; source title: Advances in modification and delivery of nucleic acid drugs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in modification and delivery of nucleic acid drugs.
10270,36250,37643976,10.3724/zdxbyxb-2023-0130,delivery,ASO/siRNA,PubMed abstract sentence 6,delivery;nanoparticle,"delivery candidate; matched derived terms: delivery, nanoparticle; source title: Advances in modification and delivery of nucleic acid drugs.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in modification and delivery of nucleic acid drugs.
10271,36251,37643976,10.3724/zdxbyxb-2023-0130,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advances in modification and delivery of nucleic acid drugs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in modification and delivery of nucleic acid drugs.
10272,36254,37635089,10.1002/chem.202301928,chemistry,ASO/siRNA,PubMed abstract sentence 7,chemical;modification;modified,"chemistry candidate; matched derived terms: chemical, modification, modified; source title: Post-Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex-Forming Ability.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Post-Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex-Forming Ability.
10277,36287,37553567,10.1186/s13046-023-02756-4,assay,ASO/siRNA,PubMed abstract sentence 4,preclinical;model,"assay candidate; matched derived terms: preclinical, model; source title: Macrophage-organoid co-culture model for identifying treatment strategies against macrophage-related gemcitabine resistance.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Macrophage-organoid co-culture model for identifying treatment strategies against macrophage-related gemcitabine resistance.
10283,36323,37470020,10.1021/acsptsci.3c00052,assay,ASO/siRNA,PubMed abstract sentence 11,phase;trial,"assay candidate; matched derived terms: phase, trial; source title: Determination of the Potential Clinical Benefits of Small Molecule Factor XIa Inhibitors in Arterial Thrombosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Determination of the Potential Clinical Benefits of Small Molecule Factor XIa Inhibitors in Arterial Thrombosis.
10288,36350,37428539,10.1099/mic.0.001361,assay,ASO/siRNA,PubMed abstract sentence 7,assay;preclinical,"assay candidate; matched derived terms: assay, preclinical; source title: Preclinical testing of antimicrobials for cystic fibrosis lung infections: current needs and future priorities.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical testing of antimicrobials for cystic fibrosis lung infections: current needs and future priorities.
10289,36353,37428145,10.1021/acs.analchem.3c02030,assay,ASO/siRNA,PubMed abstract sentence 4,assay;screen,"assay candidate; matched derived terms: assay, screen; source title: d-Penicillamine@Ag/Cu Nanocluster-Based Fluorescent Nanoneuron for Logic Screening Phosphonate-Type Organophosphate Pesticides and Steganographically Encrypting Information.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,d-Penicillamine@Ag/Cu Nanocluster-Based Fluorescent Nanoneuron for Logic Screening Phosphonate-Type Organophosphate Pesticides and Steganographically Encrypting Information.
10295,36381,37417667,10.1021/acsnano.2c11904,delivery,ASO/siRNA,PubMed abstract sentence 2,nanoparticle;lnp,"delivery candidate; matched derived terms: nanoparticle, lnp; source title: Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA-Lipid Complexes.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA-Lipid Complexes."
10300,36410,37396505,10.1016/j.gendis.2022.05.004,delivery,ASO/siRNA,PubMed abstract sentence 1,delivery;uptake,"delivery candidate; matched derived terms: delivery, uptake; source title: A novel aptamer-based small RNA delivery platform and its application to cancer therapy.",C,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A novel aptamer-based small RNA delivery platform and its application to cancer therapy.
10302,36416,37392986,10.1016/j.micinf.2023.105178,assay,ASO/siRNA,PubMed abstract sentence 3,model;phase,"assay candidate; matched derived terms: model, phase; source title: Knockdown of coagulation factor VII has potential anticoagulant and anti-inflammatory effects in a mouse model of group A streptococcal sepsis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Knockdown of coagulation factor VII has potential anticoagulant and anti-inflammatory effects in a mouse model of group A streptococcal sepsis.
10306,36424,37392659,10.1016/j.biopha.2023.115087,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy."
10312,39481,41050468,10.1016/j.csbj.2025.09.022,offtarget,ASO,PubMed abstract sentence 5,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: ASOG: AntiSense Oligonucleotide Generator.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ASOG: AntiSense Oligonucleotide Generator.
10313,39482,40646322,10.1038/s41591-025-03784-7,toxicity,ASO,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trial.
10315,39484,40781022,10.1016/j.jacl.2025.06.004,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pelacarsen: Mechanism of action and Lp(a)-lowering effect.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pelacarsen: Mechanism of action and Lp(a)-lowering effect.
10316,39485,40134378,10.1089/nat.2024.0090,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mechanistic Insights into Hybridization-Based Off-Target Activity of GalNAc-siRNA Conjugates.
10317,39486,40721084,10.1016/j.slasd.2025.100254,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Off-target effects of oligonucleotides and approaches of preclinical assessments.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Off-target effects of oligonucleotides and approaches of preclinical assessments.
10318,39487,40263630,10.1038/s41591-025-03656-0,toxicity,ASO,PubMed abstract sentence 5,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Antisense oligonucleotide treatment in a preterm infant with early-onset SCN2A developmental and epileptic encephalopathy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense oligonucleotide treatment in a preterm infant with early-onset SCN2A developmental and epileptic encephalopathy.
10319,39488,39798707,10.1016/j.jhep.2024.12.046,toxicity,ASO,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: AZD2693, a PNPLA3 antisense oligonucleotide, for the treatment of MASH in 148M homozygous participants: Two randomized phase I trials.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"AZD2693, a PNPLA3 antisense oligonucleotide, for the treatment of MASH in 148M homozygous participants: Two randomized phase I trials."
10325,39494,40098305,10.1111/cas.70024,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds.
10326,39495,40679547,10.1007/s11883-025-01315-w,toxicity,siRNA,PubMed abstract sentence 7,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: ApoC-III as Therapeutic Target: Is it Primetime for Clinical Use?",B,high_candidate,curator_rejected,reject,derived_annotations_only,ApoC-III as Therapeutic Target: Is it Primetime for Clinical Use?
10333,39502,41792408,10.1007/s11626-026-01154-2,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of ARL4C antisense oligonucleotide with reduced off-target effects and enhanced efficacy as an anti-cancer drug.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of ARL4C antisense oligonucleotide with reduced off-target effects and enhanced efficacy as an anti-cancer drug.
10338,39507,42095135,10.1016/j.omtn.2026.102930,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic;tolerability,"toxicity candidate; matched derived terms: toxicity, toxic, tolerability; source title: Development of an exon 27-skipping antisense oligonucleotide as a targeted therapy for refractory skin ulcers in Werner syndrome.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of an exon 27-skipping antisense oligonucleotide as a targeted therapy for refractory skin ulcers in Werner syndrome.
10342,39511,41981306,10.1038/s41591-026-04314-9,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy.
10343,39512,41878536,10.3389/fonc.2026.1659341,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting TLK2 with antisense oligonucleotides as a new strategy in acute myeloid leukemia.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting TLK2 with antisense oligonucleotides as a new strategy in acute myeloid leukemia.
10344,39513,41876647,10.1038/s41591-026-04262-4,toxicity,ASO,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: LRRK2-targeting antisense oligonucleotide in Parkinson's disease: a phase 1 randomized controlled trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,LRRK2-targeting antisense oligonucleotide in Parkinson's disease: a phase 1 randomized controlled trial.
10346,39515,41711123,10.1177/21593337261417504,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Investigating the Biophysical Properties and In Vivo Activity of 7',5'-Alpha-Bicyclo-DNA Phosphodiester Backbone Gapmer Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Investigating the Biophysical Properties and In Vivo Activity of 7',5'-Alpha-Bicyclo-DNA Phosphodiester Backbone Gapmer Antisense Oligonucleotides."
10352,39521,41457341,10.1177/01926233251404016,offtarget,siRNA,PubMed abstract sentence 5,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: Proceedings of the 2024 Classic Examples in Toxicologic Pathology XXXI.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Proceedings of the 2024 Classic Examples in Toxicologic Pathology XXXI.
10356,39525,41092767,10.1016/j.intimp.2025.115648,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhancement of antitumor immunity by CTLA-4 antisense oligonucleotides with CpG motif in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhancement of antitumor immunity by CTLA-4 antisense oligonucleotides with CpG motif in mice.
10363,39532,38501046,10.3389/fchem.2024.1342178,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Structure-activity relationship study of mesyl and busyl phosphoramidate antisense oligonucleotides for unaided and PSMA-mediated uptake into prostate cancer cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Structure-activity relationship study of mesyl and busyl phosphoramidate antisense oligonucleotides for unaided and PSMA-mediated uptake into prostate cancer cells.
10364,39533,38155279,10.1007/s11427-023-2434-8,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway.
10370,39539,38042877,10.1038/s41467-023-43714-0,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry.
10378,39547,39580013,10.1016/j.yrtph.2024.105743,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Carcinogenicity assessment of inotersen in Tg.rasH2 mice and Sprague-Dawley rats: Implications for 2'-MOE antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Carcinogenicity assessment of inotersen in Tg.rasH2 mice and Sprague-Dawley rats: Implications for 2'-MOE antisense oligonucleotides.
10379,39548,39476283,10.1007/s40292-024-00682-w,toxicity,ASO,PubMed abstract sentence 3,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Antisense Oligonucleotides in Dyslipidemia Management: A Review of Clinical Trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense Oligonucleotides in Dyslipidemia Management: A Review of Clinical Trials.
10382,39551,37497888,10.1002/ajh.27015,toxicity,siRNA,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: SLN124, a GalNAc conjugated 19-mer siRNA targeting tmprss6, reduces plasma iron and increases hepcidin levels of healthy volunteers.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"SLN124, a GalNAc conjugated 19-mer siRNA targeting tmprss6, reduces plasma iron and increases hepcidin levels of healthy volunteers."
10383,39552,36725319,10.1261/rna.079526.122,offtarget,siRNA,PubMed abstract sentence 9,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency.
10386,39555,42115559,10.1007/s11095-026-04114-3,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preparation of SP94-Modified Calcium Phosphate Lipid Nanoparticles Loaded with Bcl-2 siRNA and Doxorubicin and Their Targeted Therapeutic Effect on Hepatocellular Carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Preparation of SP94-Modified Calcium Phosphate Lipid Nanoparticles Loaded with Bcl-2 siRNA and Doxorubicin and Their Targeted Therapeutic Effect on Hepatocellular Carcinoma.
10389,39558,42033225,10.1093/nar/gkag343,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Direct targeting of C9ORF72 repeat RNA with fluorinated antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Direct targeting of C9ORF72 repeat RNA with fluorinated antisense oligonucleotides.
10393,39562,41919978,10.1021/acsnano.5c21452,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles.
10396,39565,41814159,10.1177/21593337251405312,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Conjugated Antisense Oligonucleotides for Skipping of Duchenne Muscular Dystrophy Exon 53: A Cautionary Study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Conjugated Antisense Oligonucleotides for Skipping of Duchenne Muscular Dystrophy Exon 53: A Cautionary Study.
10397,39566,41802273,10.1080/15257770.2026.2640829,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Improve the efficiency of gene silencing through 2'-O-methyl modification of the bases in siRNA terminus.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Improve the efficiency of gene silencing through 2'-O-methyl modification of the bases in siRNA terminus.
10399,39568,41704705,10.3389/fmed.2026.1719202,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Investigation of the activity of phosphothioate and phosphothioate-LNA-modified oligonucleotides against HIV-1.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Investigation of the activity of phosphothioate and phosphothioate-LNA-modified oligonucleotides against HIV-1.
10400,39569,41604465,10.1126/scitranslmed.adt1211,offtarget,siRNA,PubMed abstract sentence 8,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: A first-in-class small-molecule inhibitor targeting AVIL exhibits safety and antitumor efficacy in preclinical models of glioblastoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A first-in-class small-molecule inhibitor targeting AVIL exhibits safety and antitumor efficacy in preclinical models of glioblastoma.
10403,39572,41277693,10.1093/nar/gkaf1263,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages.
10410,39579,40946728,10.1016/j.jconrel.2025.114233,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ultraviolet-tyrosinase cascade caged antisense oligonucleotide for precise treatment of hyperpigmentation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ultraviolet-tyrosinase cascade caged antisense oligonucleotide for precise treatment of hyperpigmentation.
10411,39580,40926414,10.1016/j.ymthe.2025.08.045,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides.
10413,39582,40849139,10.1016/S0140-6736(25)00979-1,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense oligonucleotide DGAT-2 inhibitor, ION224, for metabolic dysfunction-associated steatohepatitis (ION224-CS2): results of a 51-week, multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Antisense oligonucleotide DGAT-2 inhibitor, ION224, for metabolic dysfunction-associated steatohepatitis (ION224-CS2): results of a 51-week, multicentre, randomised, double-blind, placebo-controlled, phase 2 trial."
10418,39587,40687881,10.1515/medgen-2025-2025,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense oligonucleotide therapies for monogenic disorders.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense oligonucleotide therapies for monogenic disorders.
10423,39592,40414239,10.1016/S0140-6736(25)00513-6,toxicity,ASO,PubMed abstract sentence 9,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series."
10424,39593,40367190,10.1126/scitranslmed.adv4656,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Intra-amniotic antisense oligonucleotide treatment improves phenotypes in preclinical models of spinal muscular atrophy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Intra-amniotic antisense oligonucleotide treatment improves phenotypes in preclinical models of spinal muscular atrophy.
10432,39601,39937271,10.1158/1078-0432.CCR-24-1818,toxicity,ASO,PubMed abstract sentence 6,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: AZD8701, an Antisense Oligonucleotide Targeting FOXP3 mRNA, as Monotherapy and in Combination with Durvalumab: A Phase I Trial in Patients with Advanced Solid Tumors.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"AZD8701, an Antisense Oligonucleotide Targeting FOXP3 mRNA, as Monotherapy and in Combination with Durvalumab: A Phase I Trial in Patients with Advanced Solid Tumors."
10434,39603,39882764,10.1177/01926233241311277,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Characterizing Antisense Oligonucleotide-Induced Histopathology Findings in Spinal Cord of Mauritius Cynomolgus Monkeys by Molecular Localization Investigation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Characterizing Antisense Oligonucleotide-Induced Histopathology Findings in Spinal Cord of Mauritius Cynomolgus Monkeys by Molecular Localization Investigation.
10439,39608,39473221,10.1002/acn3.52234,toxicity,ASO,PubMed abstract sentence 5,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: Rethinking antisense oligonucleotide therapeutics for amyotrophic lateral sclerosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rethinking antisense oligonucleotide therapeutics for amyotrophic lateral sclerosis.
10440,39609,39460376,10.1016/j.ymthe.2024.10.024,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system.
10443,39612,39377066,10.1016/j.omtn.2024.102250,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Splice-switching antisense oligonucleotide controlling tumor suppressor REST is a novel therapeutic medicine for neuroendocrine cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Splice-switching antisense oligonucleotide controlling tumor suppressor REST is a novel therapeutic medicine for neuroendocrine cancer.
10446,39615,38040383,10.1016/j.nbd.2023.106368,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice.
10448,39617,37834294,10.3390/ijms241914846,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antiviral Efficacy of RNase H-Dependent Gapmer Antisense Oligonucleotides against Japanese Encephalitis Virus.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antiviral Efficacy of RNase H-Dependent Gapmer Antisense Oligonucleotides against Japanese Encephalitis Virus.
10453,39622,42077930,10.12688/wellcomeopenres.23656.1,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: LwaCas13a indiscriminately targets the human transcriptome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,LwaCas13a indiscriminately targets the human transcriptome.
10459,39628,42214258,10.1016/j.dmd.2026.100301,toxicity,siRNA,PubMed abstract sentence 1,safety;renal,"toxicity candidate; matched derived terms: safety, renal; source title: Comparative evaluation of ultrafiltration and EMSA formats for siRNA plasma protein binding: Methodological determinants and artifacts.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Comparative evaluation of ultrafiltration and EMSA formats for siRNA plasma protein binding: Methodological determinants and artifacts.
10461,39630,42193329,10.3390/biomedicines14051002,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Effect of Short-Anchored PEGylated Lipids on Lipid Nanoparticle Characterization Profiles, Stability, and Efficacy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Effect of Short-Anchored PEGylated Lipids on Lipid Nanoparticle Characterization Profiles, Stability, and Efficacy."
10468,39637,42155236,10.1016/j.jcis.2026.140735,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PEG-lipid structure controls in vitro PEG shedding, surface remodeling, and timing of lipid nanoparticle-mediated silencing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"PEG-lipid structure controls in vitro PEG shedding, surface remodeling, and timing of lipid nanoparticle-mediated silencing."
10474,39643,42135452,10.1038/s41598-026-53340-7,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Combined PD-1 and TIGIT blockade via siRNA enhances anti-leukemic T-cell function and promotes AML cell apoptosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Combined PD-1 and TIGIT blockade via siRNA enhances anti-leukemic T-cell function and promotes AML cell apoptosis.
10475,39644,42134451,10.1016/j.drudis.2026.104697,offtarget,siRNA,PubMed abstract sentence 2,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Advances in siRNA and synbiotic therapies for colorectal cancer: a molecular and microbiota perspective.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in siRNA and synbiotic therapies for colorectal cancer: a molecular and microbiota perspective.
10476,39645,42134451,10.1016/j.drudis.2026.104697,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advances in siRNA and synbiotic therapies for colorectal cancer: a molecular and microbiota perspective.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in siRNA and synbiotic therapies for colorectal cancer: a molecular and microbiota perspective.
10479,39648,42097228,10.1016/j.jconrel.2026.114973,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In vivo genetic circuit drives systemic PARP1 siRNA assembly into small extracellular vesicles for BRCA2-deficient breast cancer therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In vivo genetic circuit drives systemic PARP1 siRNA assembly into small extracellular vesicles for BRCA2-deficient breast cancer therapy.
10484,39653,42005705,10.2147/IJN.S588018,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preparation and Antitumor Activity of METTL3 SiRNA Nanoparticles Carried by Hypoxia Sensitive Polymer (mPEG-Azo-PEI).",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preparation and Antitumor Activity of METTL3 SiRNA Nanoparticles Carried by Hypoxia Sensitive Polymer (mPEG-Azo-PEI).
10504,39673,41779311,10.1186/s11671-026-04487-9,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoparticle based siRNA therapeutics for ovarian cancer overcoming drug resistance and future directions.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanoparticle based siRNA therapeutics for ovarian cancer overcoming drug resistance and future directions.
10506,39675,41764711,10.1186/s43044-026-00724-9,toxicity,siRNA,PubMed abstract sentence 8,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Zilebesiran: an RNA interference agent-its need and potential to transform hypertension treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Zilebesiran: an RNA interference agent-its need and potential to transform hypertension treatment.
10519,39688,41974290,10.1016/j.fsi.2026.111328,offtarget,siRNA,PubMed abstract sentence 5,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: NFIL3-dependent regulation of NF-κB pathway mediates alginic oligosaccharide alleviation of nitrite immunotoxicity in Procambarus clarkii.",B,high_candidate,curator_rejected,reject,derived_annotations_only,NFIL3-dependent regulation of NF-κB pathway mediates alginic oligosaccharide alleviation of nitrite immunotoxicity in Procambarus clarkii.
10523,39692,41066632,10.1093/hmg/ddaf153,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Determining off-target effects of splice-switching antisense oligonucleotides using short read RNAseq in neuronally differentiated human induced pluripotent stem cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Determining off-target effects of splice-switching antisense oligonucleotides using short read RNAseq in neuronally differentiated human induced pluripotent stem cells.
10525,39694,39192097,10.1007/s10120-024-01548-9,offtarget,ASO,PubMed abstract sentence 10,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preclinical toxicological assessment of amido-bridged nucleic acid-modified antisense oligonucleotides targeting synaptotagmin XIII for intra-abdominal treatment of peritoneal metastasis of gastric cancer.
10530,39699,37326950,10.1002/npr2.12335,toxicity,ASO,PubMed abstract sentence 5,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Systemic administration of the antisense oligonucleotide NS-089/NCNP-02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/II clinical trial.
10533,39702,35861704,10.1089/nat.2022.0005,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'- O -Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs.
10535,39704,35057094,10.3390/pharmaceutics14010200,toxicity,ASO,PubMed abstract sentence 5,toxic;safety;tolerability,"toxicity candidate; matched derived terms: toxic, safety, tolerability; source title: Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders.
10538,39707,32178467,10.3390/ijms21061952,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.
10543,39712,41722569,10.1016/j.ajhg.2026.01.016,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic;safety;renal,"toxicity candidate; matched derived terms: toxicity, toxic, safety, renal; source title: Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for myotonic dystrophy type 1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for myotonic dystrophy type 1.
10544,39713,41720270,10.1016/j.jconrel.2026.114740,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid nanoparticle (LNP)-mediated cytoplasmic expression of single-stranded DNA and its application in Mpox vaccine.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid nanoparticle (LNP)-mediated cytoplasmic expression of single-stranded DNA and its application in Mpox vaccine.
10547,39716,41411532,10.1021/acsinfecdis.5c00779,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Rational Design of Chimeric Antisense Oligonucleotides that Target FMN Riboswitch mRNAs and Inhibit the Growth of Methicillin-Resistant Staphylococcus aureus .",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Rational Design of Chimeric Antisense Oligonucleotides that Target FMN Riboswitch mRNAs and Inhibit the Growth of Methicillin-Resistant Staphylococcus aureus.
10553,39722,40726257,10.1021/acs.molpharmaceut.5c00412,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Red Blood Cell Membrane-Camouflaged Reduction-Responsive Polyethylenimine-Based Nanoparticles for Enhanced Antitumor Efficacy of Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Red Blood Cell Membrane-Camouflaged Reduction-Responsive Polyethylenimine-Based Nanoparticles for Enhanced Antitumor Efficacy of Antisense Oligonucleotides.
10554,39723,40720030,10.1007/978-1-0716-4730-1_23,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Use of Tricyclo-DNA Antisense Oligonucleotides for Exon-Skipping.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Use of Tricyclo-DNA Antisense Oligonucleotides for Exon-Skipping.
10560,39729,39286058,10.1183/23120541.00986-2023,toxicity,ASO,PubMed abstract sentence 14,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Randomised, phase 1/2a trial of ION-827359, an antisense oligonucleotide inhibitor of ENaC.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Randomised, phase 1/2a trial of ION-827359, an antisense oligonucleotide inhibitor of ENaC."
10565,39734,38706632,10.1016/j.omtn.2024.102186,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ASOptimizer: Optimizing antisense oligonucleotides through deep learning for IDO1 gene regulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ASOptimizer: Optimizing antisense oligonucleotides through deep learning for IDO1 gene regulation.
10571,39740,38369231,10.1016/j.exer.2024.109833,offtarget,ASO,PubMed abstract sentence 13,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: Allele-specific antisense oligonucleotides for the treatment of BEST1-related dominantly inherited retinal diseases: An in vitro model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Allele-specific antisense oligonucleotides for the treatment of BEST1-related dominantly inherited retinal diseases: An in vitro model.
10577,39746,36228827,10.1053/j.ajkd.2022.08.018,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Focal Segmental Glomerulosclerosis Complicating Therapy With Inotersen, an Antisense Oligonucleotide Inhibitor: A Case Report.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Focal Segmental Glomerulosclerosis Complicating Therapy With Inotersen, an Antisense Oligonucleotide Inhibitor: A Case Report."
10578,39747,36421306,10.3390/antibiotics11111662,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting SAM-I Riboswitch Using Antisense Oligonucleotide Technology for Inhibiting the Growth of Staphylococcus aureus and Listeria monocytogenes .",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting SAM-I Riboswitch Using Antisense Oligonucleotide Technology for Inhibiting the Growth of Staphylococcus aureus and Listeria monocytogenes.
10582,39751,36090761,10.1016/j.omtn.2022.07.027,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.
10583,39752,35860385,10.1016/j.omtn.2022.06.015,toxicity,ASO,PubMed abstract sentence 10,adverse;tolerability,"toxicity candidate; matched derived terms: adverse, tolerability; source title: Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models."
10585,39754,35221287,10.1124/dmd.121.000417,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration-Approved Antisense Oligonucleotide Drugs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration-Approved Antisense Oligonucleotide Drugs."
10587,39756,35080855,10.1021/acs.bioconjchem.1c00505,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gene Regulation Using Nanodiscs Modified with HIF-1-α Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Gene Regulation Using Nanodiscs Modified with HIF-1-α Antisense Oligonucleotides.
10589,39758,34832896,10.3390/ph14111113,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Intramuscular Evaluation of Chimeric Locked Nucleic Acid/2' O Methyl-Modified Antisense Oligonucleotides for Targeted Exon 23 Skipping in Mdx Mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Intramuscular Evaluation of Chimeric Locked Nucleic Acid/2'OMethyl-Modified Antisense Oligonucleotides for Targeted Exon 23 Skipping in Mdx Mice.
10592,39761,34683974,10.3390/pharmaceutics13101681,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia.
10593,39762,34417625,10.1093/nar/gkab718,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
10594,39763,34141070,10.1021/acsmedchemlett.1c00072,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides."
10597,39766,33860461,10.1007/s13311-021-01045-2,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling.
10600,39769,33326082,10.1007/978-1-0716-1158-6_17,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In Vivo Administration of Therapeutic Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In Vivo Administration of Therapeutic Antisense Oligonucleotides.
10602,39771,33288723,10.1073/pnas.2016158117,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.
10606,39775,32589504,10.1089/nat.2020.0864,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gapmer Antisense Oligonucleotides Targeting 5S Ribosomal RNA Can Reduce Mature 5S Ribosomal RNA by Two Mechanisms.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gapmer Antisense Oligonucleotides Targeting 5S Ribosomal RNA Can Reduce Mature 5S Ribosomal RNA by Two Mechanisms.
10607,39776,32485363,10.1016/j.bone.2020.115461,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense oligonucleotide-based therapies for the treatment of osteoarthritis: Opportunities and roadblocks.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense oligonucleotide-based therapies for the treatment of osteoarthritis: Opportunities and roadblocks.
10609,39778,31873063,10.1089/nat.2019.0811,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Systemic Evaluation of Chimeric LNA/2'-O-Methyl Steric Blockers for Myotonic Dystrophy Type 1 Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Systemic Evaluation of Chimeric LNA/2'-O-Methyl Steric Blockers for Myotonic Dystrophy Type 1 Therapy.
10612,39781,31617782,10.1080/15257770.2019.1677911,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Effect of modular conjugation strategy for N -acetylgalactosamine-targeted antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides.
10616,39785,41936854,10.1016/j.tox.2026.154457,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Reduced NR2F6 expression reshapes the VPA-induced transcriptome in human hepatocytes and increases lipid accumulation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Reduced NR2F6 expression reshapes the VPA-induced transcriptome in human hepatocytes and increases lipid accumulation.
10620,39789,41589899,10.1021/acs.jafc.5c11406,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic;safety;risk,"toxicity candidate; matched derived terms: toxicity, toxic, safety, risk; source title: Enhancing Global Oilseed Production and Sustainable Agriculture through Nanoenabled Strategies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhancing Global Oilseed Production and Sustainable Agriculture through Nanoenabled Strategies.
10622,39791,32202774,10.1021/jacs.9b13524,toxicity,ASO,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.
10634,39803,41832714,10.2174/0113816128410562251204115232,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advances in siRNA-Loaded Nanocarriers: Harnessing Cutting-Edge Technologies for Precision Cancer Treatment.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Advances in siRNA-Loaded Nanocarriers: Harnessing Cutting-Edge Technologies for Precision Cancer Treatment.
10639,39808,41780418,10.1016/j.jcyt.2025.102044,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid nanoparticle-points to consider in assessing materials quality for ribonucleic acid-based therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipid nanoparticle-points to consider in assessing materials quality for ribonucleic acid-based therapeutics.
10647,39816,41590508,10.3390/jpm16010015,toxicity,siRNA,PubMed abstract sentence 9,safety;renal,"toxicity candidate; matched derived terms: safety, renal; source title: The Dawn of Precision Medicine in Pediatric Nephrology: Lumasiran and the Era of siRNA Therapies for Primary Hyperoxaluria Type 1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Dawn of Precision Medicine in Pediatric Nephrology: Lumasiran and the Era of siRNA Therapies for Primary Hyperoxaluria Type 1.
10648,39817,41570670,10.1016/j.biomaterials.2026.124002,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transforming lipid nanoparticles into radio-activatable therapeutics through synergistic ferroptosis for enhanced cancer radiotherapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Transforming lipid nanoparticles into radio-activatable therapeutics through synergistic ferroptosis for enhanced cancer radiotherapy.
10651,39820,41512823,10.1016/j.molcel.2025.12.009,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
10652,39821,41512172,10.1182/bloodadvances.2025018348,toxicity,siRNA,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: RNA interference therapy targeting coagulation factor XI: a first-in-human trial of RBD4059 (vortosiran).",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA interference therapy targeting coagulation factor XI: a first-in-human trial of RBD4059 (vortosiran).
10654,39823,41437666,10.1002/anie.202524814,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Photoelectrocatalytic Platform for Sequence-Unrestricted Modification of Oligonucleotide Backbones.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Photoelectrocatalytic Platform for Sequence-Unrestricted Modification of Oligonucleotide Backbones.
10655,39824,41424446,10.1021/acsnano.5c18243,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Leveraging Cisplatin-Derived Prodrugs as Helper Lipids in LNPs to Boost the Efficacy of Cancer Chemoimmunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Leveraging Cisplatin-Derived Prodrugs as Helper Lipids in LNPs to Boost the Efficacy of Cancer Chemoimmunotherapy.
10658,39827,41220296,10.1002/adhm.202503748,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Photosensitizing Lipid Nanoparticles for Ferroptosis-Enhanced Photodynamic Cancer Therapy via GPX4 Silencing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Photosensitizing Lipid Nanoparticles for Ferroptosis-Enhanced Photodynamic Cancer Therapy via GPX4 Silencing.
10659,39828,41213485,10.1016/j.ijpharm.2025.126364,offtarget,ASO,PubMed abstract sentence 4,off-target;hybridization;unintended,"offtarget candidate; matched derived terms: off-target, hybridization, unintended; source title: Theoretical calculation of the amounts of nucleotide deletion impurities in oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Theoretical calculation of the amounts of nucleotide deletion impurities in oligonucleotides.
10666,39835,41463125,10.3390/biomedicines13123118,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Reversing the Irreversible: miRNA-Targeting Mesyl Phosphoramidate Oligonucleotides Restore Sensitivity to Cisplatin and Doxorubicin of KB-8-5 Epidermoid Carcinoma Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Reversing the Irreversible: miRNA-Targeting Mesyl Phosphoramidate Oligonucleotides Restore Sensitivity to Cisplatin and Doxorubicin of KB-8-5 Epidermoid Carcinoma Cells.
10667,39836,41429785,10.1038/s41467-025-66765-x,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Morpholino-RNA duplex exhibits robust, sustained, and safe steric-block antisense activity by intracerebroventricular and intrathecal injection."
10670,39839,41393714,10.7759/cureus.96715,toxicity,ASO,PubMed abstract sentence 5,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Olezarsen: A Next-Generation Antisense Therapy for Hypertriglyceridemia and Familial Chylomicronemia Syndrome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Olezarsen: A Next-Generation Antisense Therapy for Hypertriglyceridemia and Familial Chylomicronemia Syndrome.
10676,39845,41226756,10.3390/ijms262110717,toxicity,siRNA,PubMed abstract sentence 7,safety;risk;adverse,"toxicity candidate; matched derived terms: safety, risk, adverse; source title: Zilebesiran as an Innovative siRNA-Based Therapeutic Approach for Hypertension: Emerging Perspectives in Cardiovascular Medicine.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Zilebesiran as an Innovative siRNA-Based Therapeutic Approach for Hypertension: Emerging Perspectives in Cardiovascular Medicine.
10677,39846,41163544,10.1093/nar/gkaf1063,toxicity,siRNA,PubMed abstract sentence 7,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia.
10679,39848,41155969,10.3390/pharmaceutics17101334,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipid Nanoparticle-Mediated RNAi Against GIPC1 Overcomes Chemoresistance in Pancreatic Ductal Adenocarcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Lipid Nanoparticle-Mediated RNAi Against GIPC1 Overcomes Chemoresistance in Pancreatic Ductal Adenocarcinoma.
10682,39851,41043736,10.1016/j.ijbiomac.2025.148058,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Incorporation of monophosphoryl lipid A and CpG-oligodeoxynucleotides into lipid nanoparticles activates toll-like receptor signaling pathways while maintaining antigen expression for mRNA-based vaccinations.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Incorporation of monophosphoryl lipid A and CpG-oligodeoxynucleotides into lipid nanoparticles activates toll-like receptor signaling pathways while maintaining antigen expression for mRNA-based vaccinations.
10683,39852,41027940,10.1038/s41467-025-63718-2,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineered exosomes with Kras G12D specific siRNA in pancreatic cancer: a phase I study with immunological correlates.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Engineered exosomes with Kras(G12D) specific siRNA in pancreatic cancer: a phase I study with immunological correlates.
10685,39854,41022318,10.1016/j.ejps.2025.107292,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advances in the pharmaceutical development of antibody-oligonucleotide conjugates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in the pharmaceutical development of antibody-oligonucleotide conjugates.
10693,39862,40888416,10.1021/acs.analchem.5c02727,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Novel Hybrid LC-MS/MS Methodology for the Quantitative Bioanalysis of Antibody-siRNA Conjugates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Novel Hybrid LC-MS/MS Methodology for the Quantitative Bioanalysis of Antibody-siRNA Conjugates.
10696,39865,40703143,10.1007/s12170-025-00759-8,toxicity,siRNA,PubMed abstract sentence 9,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Current Clinical Trials for Treating Elevated Lipoprotein(a).",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Current Clinical Trials for Treating Elevated Lipoprotein(a).
10700,39869,40672232,10.1101/2025.07.11.664364,offtarget,ASO,PubMed abstract sentence 6,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: Targeted RNA editing by direct delivery of an adenosine deaminase-antisense oligo conjugate.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeted RNA editing by direct delivery of an adenosine deaminase-antisense oligo conjugate.
10702,39871,40615758,10.1007/s12672-025-03070-5,toxicity,siRNA,PubMed abstract sentence 7,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: mRNA vaccines and SiRNAs targeting cancer immunotherapy: challenges and opportunities.",B,high_candidate,curator_rejected,reject,derived_annotations_only,mRNA vaccines and SiRNAs targeting cancer immunotherapy: challenges and opportunities.
10704,39873,40609116,10.1021/acs.bioconjchem.5c00205,toxicity,siRNA,PubMed abstract sentence 5,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Multicheckpoint Cellular Targeting of siRNAs Using Antibody-Directed Lipid-Polymer Hybrid Nanoparticles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Multicheckpoint Cellular Targeting of siRNAs Using Antibody-Directed Lipid-Polymer Hybrid Nanoparticles.
10707,39876,40581300,10.1016/j.jhep.2025.05.031,toxicity,ASO/siRNA,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Phase I randomized double-blind study of an RNA interference therapeutic targeting HSD17B13 for metabolic dysfunction-associated steatohepatitis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phase I randomized double-blind study of an RNA interference therapeutic targeting HSD17B13 for metabolic dysfunction-associated steatohepatitis.
10710,39879,40454845,10.1097/CRD.0000000000000962,toxicity,ASO/siRNA,PubMed abstract sentence 10,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Zilebesiran: A Novel RNA Interference Therapeutic for Hypertension.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Zilebesiran: A Novel RNA Interference Therapeutic for Hypertension.
10714,39883,40438965,10.1080/20415990.2025.2506977,toxicity,ASO/siRNA,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: The role of excipients in lipid nanoparticle metabolism: implications for enhanced therapeutic effect.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The role of excipients in lipid nanoparticle metabolism: implications for enhanced therapeutic effect.
10720,39889,40280496,10.1016/j.spinee.2025.04.021,toxicity,ASO,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: NF-kappa B Oligo DNA decoy provides 12 months of pain relief and disc height restoration for patients with chronic discogenic low back pain-a randomized clinical trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,NF-kappa B Oligo DNA decoy provides 12 months of pain relief and disc height restoration for patients with chronic discogenic low back pain-a randomized clinical trial.
10728,39897,39978599,10.1016/j.jhep.2025.02.007,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Developing splice-switching oligonucleotides for urea cycle disorder using an integrated diagnostic and therapeutic platform.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Developing splice-switching oligonucleotides for urea cycle disorder using an integrated diagnostic and therapeutic platform.
10731,39900,39960827,10.1089/nat.2024.0085,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Combined 20-Hydroxyecdysone and Antisense-Mediated Exon Skipping Improve Functional Outcomes in a Mouse Model of Duchenne Muscular Dystrophy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Combined 20-Hydroxyecdysone and Antisense-Mediated Exon Skipping Improve Functional Outcomes in a Mouse Model of Duchenne Muscular Dystrophy.
10732,39901,39948537,10.1186/s12885-025-13623-0,toxicity,ASO,PubMed abstract sentence 7,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Investigator-initiated phase I trial of an oligonucleotide therapeutic targeting long noncoding RNA TUG 1 for recurrent glioblastoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Investigator-initiated phase I trial of an oligonucleotide therapeutic targeting long noncoding RNA TUG 1 for recurrent glioblastoma.
10740,39909,39385468,10.1016/j.ymthe.2024.10.003,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Efficient and safe in vivo treatment of primary hyperoxaluria type 1 via LNP-CRISPR-Cas9-mediated glycolate oxidase disruption.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficient and safe in vivo treatment of primary hyperoxaluria type 1 via LNP-CRISPR-Cas9-mediated glycolate oxidase disruption.
10752,39921,38945909,10.1254/fpj.24018,offtarget,siRNA,PubMed abstract sentence 5,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: [Pharmacological and clinical profile of inclisiran sodium, a long-acting LDL cholesterol lowering siRNA, LEQVIO for s.c. injection syringe 300 ‍mg].",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"[Pharmacological and clinical profile of inclisiran sodium, a long-acting LDL cholesterol lowering siRNA, LEQVIO for s.c. injection syringe 300 ‍mg]."
10753,39922,38945909,10.1254/fpj.24018,toxicity,siRNA,PubMed abstract sentence 5,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: [Pharmacological and clinical profile of inclisiran sodium, a long-acting LDL cholesterol lowering siRNA, LEQVIO for s.c. injection syringe 300 ‍mg].",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"[Pharmacological and clinical profile of inclisiran sodium, a long-acting LDL cholesterol lowering siRNA, LEQVIO for s.c. injection syringe 300 ‍mg]."
10760,39929,38688053,10.1016/j.chroma.2024.464945,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Influence of oligonucleotides structures for separation of diastereomers by capillary electrophoresis method using polyvinylpyrrolidone 1,300,000.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Influence of oligonucleotides structures for separation of diastereomers by capillary electrophoresis method using polyvinylpyrrolidone 1,300,000."
10766,39935,38435821,10.1002/btm2.10601,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A landscape of recent advances in lipid nanoparticles and their translational potential for the treatment of solid tumors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A landscape of recent advances in lipid nanoparticles and their translational potential for the treatment of solid tumors.
10767,39936,38346479,10.1016/j.ejpb.2024.114213,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles.
10772,39941,38253203,10.1016/j.jconrel.2024.01.037,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques.
10775,39944,38145661,10.1016/j.jconrel.2023.12.035,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enabling safer, more potent oligonucleotide therapeutics with bottlebrush polymer conjugates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Enabling safer, more potent oligonucleotide therapeutics with bottlebrush polymer conjugates."
10776,39945,37579889,10.1016/j.ejpb.2023.08.002,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluating how cationic lipid affects mRNA-LNP physical properties and biodistribution.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluating how cationic lipid affects mRNA-LNP physical properties and biodistribution.
10784,39953,37438524,10.1038/s41586-023-06277-0,toxicity,ASO,PubMed abstract sentence 6,adverse;tolerability,"toxicity candidate; matched derived terms: adverse, tolerability; source title: A framework for individualized splice-switching oligonucleotide therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A framework for individualized splice-switching oligonucleotide therapy.
10787,39956,37027823,10.1182/blood.2022018662,toxicity,ASO/siRNA,PubMed abstract sentence 10,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: RNA interference therapy in acute hepatic porphyrias.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA interference therapy in acute hepatic porphyrias.
10789,39958,36839919,10.3390/pharmaceutics15020597,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Effect of PEG Anchor and Serum on Lipid Nanoparticles: Development of a Nanoparticles Tracking Method.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Effect of PEG Anchor and Serum on Lipid Nanoparticles: Development of a Nanoparticles Tracking Method.
10790,39959,36798116,10.3389/fimmu.2023.1006741,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis."
10792,39961,36735581,10.1089/nat.2022.0046,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chemical Modifications and Design Influence the Potency of Huntingtin Anti-Gene Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Chemical Modifications and Design Influence the Potency of Huntingtin Anti-Gene Oligonucleotides.
10793,39962,36727438,10.1093/nar/gkad023,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics.
10797,39966,36520934,10.1371/journal.pone.0276905,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of c-Rel expression in myeloid and lymphoid cells with distearoyl -phosphatidylserine (DSPS) liposomal nanoparticles encapsulating therapeutic siRNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Inhibition of c-Rel expression in myeloid and lymphoid cells with distearoyl -phosphatidylserine (DSPS) liposomal nanoparticles encapsulating therapeutic siRNA.
10800,39969,36117149,10.1111/1759-7714.14618,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Construction of PEI-EGFR-PD-L1-siRNA dual functional nano-vaccine and therapeutic efficacy evaluation for lung cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Construction of PEI-EGFR-PD-L1-siRNA dual functional nano-vaccine and therapeutic efficacy evaluation for lung cancer.
10801,39970,36037350,10.1073/pnas.2207956119,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing.
10806,39975,35701833,10.1111/cas.15461,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antitumoral RNA-targeted oligonucleotide therapeutics: The third pillar after small molecule inhibitors and antibodies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antitumoral RNA-targeted oligonucleotide therapeutics: The third pillar after small molecule inhibitors and antibodies.
10808,39977,35436109,10.1021/acsinfecdis.2c00089,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense Peptide Nucleic Acid-Diaminobutanoic Acid Dendron Conjugates with SbmA-Independent Antimicrobial Activity against Gram-Negative Bacteria.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense Peptide Nucleic Acid-Diaminobutanoic Acid Dendron Conjugates with SbmA-Independent Antimicrobial Activity against Gram-Negative Bacteria.
10809,39978,35155859,10.1016/j.ekir.2021.11.011,toxicity,ASO,PubMed abstract sentence 1,risk;renal,"toxicity candidate; matched derived terms: risk, renal; source title: Phase 2 Study of the Factor XI Antisense Inhibitor IONIS-FXI Rx in Patients With ESRD.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Phase 2 Study of the Factor XI Antisense Inhibitor IONIS-FXI(Rx) in Patients With ESRD.
10810,39979,35027752,10.1038/s41591-021-01634-w,toxicity,siRNA,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a).",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a).
10811,39980,34766620,10.14573/altex.2108241,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics.
10816,39985,34520257,10.1089/nat.2021.0021,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System.
10817,39986,34222719,10.1016/j.jacbts.2021.04.004,toxicity,ASO,PubMed abstract sentence 6,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Antisense Inhibition of Angiotensinogen With IONIS-AGT-L Rx : Results of Phase 1 and Phase 2 Studies.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense Inhibition of Angiotensinogen With IONIS-AGT-L(Rx): Results of Phase 1 and Phase 2 Studies.
10819,39988,34140675,10.1038/s41565-021-00928-x,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Conformation-sensitive targeting of lipid nanoparticles for RNA therapeutics.
10820,39989,34101472,10.1021/acs.langmuir.1c00530,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic;tolerability,"toxicity candidate; matched derived terms: toxicity, toxic, tolerability; source title: Scalable Production of Lipid Nanoparticles Containing Amphotericin B.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Scalable Production of Lipid Nanoparticles Containing Amphotericin B.
10824,39993,33567244,10.1089/nat.2020.0907,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides.
10825,39994,33278337,10.1111/cts.12945,toxicity,ASO,PubMed abstract sentence 3,safety;renal,"toxicity candidate; matched derived terms: safety, renal; source title: Clinical Pharmacology Studies Supporting Oligonucleotide Therapy Development: An Assessment of Therapies Approved and in Development Between 2012 and 2018.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Clinical Pharmacology Studies Supporting Oligonucleotide Therapy Development: An Assessment of Therapies Approved and in Development Between 2012 and 2018.
10828,39997,32865788,10.1007/978-1-0716-0771-8_10,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility.
10830,39999,32330214,10.1039/c9tb02700a,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Amphetamine decorated cationic lipid nanoparticles cross the blood-brain barrier: therapeutic promise for combating glioblastoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Amphetamine decorated cationic lipid nanoparticles cross the blood-brain barrier: therapeutic promise for combating glioblastoma.
10833,40002,31836192,10.1016/j.tips.2019.10.009,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Oligonucleotides to the (Gene) Rescue: FDA Approvals 2017-2019.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Oligonucleotides to the (Gene) Rescue: FDA Approvals 2017-2019.
10834,40003,31792921,10.1007/s40291-019-00438-6,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Leading RNA Interference Therapeutics Part 2: Silencing Delta-Aminolevulinic Acid Synthase 1, with a Focus on Givosiran.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Leading RNA Interference Therapeutics Part 2: Silencing Delta-Aminolevulinic Acid Synthase 1, with a Focus on Givosiran."
10835,40004,41709935,10.33160/yam.2026.02.001,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Next-Generation Artificial Intelligence for ADME Prediction in Drug Discovery: From Small Molecules to Biologics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Next-Generation Artificial Intelligence for ADME Prediction in Drug Discovery: From Small Molecules to Biologics.
10851,40020,29390093,10.1093/nar/gky060,offtarget,ASO,PubMed abstract sentence 6,off-target;hybridization,"offtarget candidate; matched derived terms: off-target, hybridization; source title: Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.
10853,40022,26553810,10.1093/nar/gkv1210,offtarget,ASO,PubMed abstract sentence 8,off-target;unintended,"offtarget candidate; matched derived terms: off-target, unintended; source title: Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
10854,40023,28918038,10.1016/j.omtn.2017.07.003,offtarget,ASO,PubMed abstract sentence 6,off-target;transcriptome;hybridization,"offtarget candidate; matched derived terms: off-target, transcriptome, hybridization; source title: Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.
10880,40049,33314011,10.1007/s40291-020-00504-4,toxicity,ASO,PubMed abstract sentence 8,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: Using RNA-seq to Assess Off-Target Effects of Antisense Oligonucleotides in Human Cell Lines.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Using RNA-seq to Assess Off-Target Effects of Antisense Oligonucleotides in Human Cell Lines.
10888,40057,40526144,10.1021/acs.jafc.4c11433,toxicity,siRNA,PubMed abstract sentence 12,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Using Transcriptome Diversity to Evaluate the Off-Target Effects of miRNA-Mediated Transgenic Rice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Using Transcriptome Diversity to Evaluate the Off-Target Effects of miRNA-Mediated Transgenic Rice.
10890,40059,31009315,10.1089/nat.2018.0773,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic;safety;renal,"toxicity candidate; matched derived terms: toxicity, toxic, safety, renal; source title: Evaluating the Impact of Variable Phosphorothioate Content in Tricyclo-DNA Antisense Oligonucleotides in a Duchenne Muscular Dystrophy Mouse Model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Evaluating the Impact of Variable Phosphorothioate Content in Tricyclo-DNA Antisense Oligonucleotides in a Duchenne Muscular Dystrophy Mouse Model.
10892,40061,30622178,10.1073/pnas.1813376116,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties.
10893,40062,30464402,10.2147/DDDT.S179008,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Saponins enhance exon skipping of 2'-O-methyl phosphorothioate oligonucleotide in vitro and in vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Saponins enhance exon skipping of 2'-O-methyl phosphorothioate oligonucleotide in vitro and in vivo.
10894,40063,28627628,10.3892/mmr.2017.6778,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Phosphorothioate‑modified antisense oligonucleotides against human telomerase reverse transcriptase sensitize cancer cells to radiotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phosphorothioate‑modified antisense oligonucleotides against human telomerase reverse transcriptase sensitize cancer cells to radiotherapy.
10895,40064,24131982,10.1038/gt.2013.57,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pluronic-PEI copolymers enhance exon-skipping of 2'-O-methyl phosphorothioate oligonucleotide in cell culture and dystrophic mdx mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pluronic-PEI copolymers enhance exon-skipping of 2'-O-methyl phosphorothioate oligonucleotide in cell culture and dystrophic mdx mice.
10902,40071,34648028,10.1093/nar/gkab916,offtarget,siRNA,PubMed abstract sentence 1,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
10903,40072,34648028,10.1093/nar/gkab916,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
10911,40080,28129130,10.1016/j.ymthe.2016.10.019,toxicity,siRNA,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate.
10914,40083,26643897,10.1089/nat.2015.0576,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Development of a Method for Profiling Protein Interactions with LNA-Modified Antisense Oligonucleotides Using Protein Microarrays.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of a Method for Profiling Protein Interactions with LNA-Modified Antisense Oligonucleotides Using Protein Microarrays.
10917,40086,20498851,10.1371/journal.pone.0010682,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.
10920,40089,36060259,10.3389/fmolb.2022.955753,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transcriptome changes in DM1 patients' tissues are governed by the RNA interference pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transcriptome changes in DM1 patients' tissues are governed by the RNA interference pathway.
10922,40091,35852833,10.1089/nat.2021.0107,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides.
10927,40096,32356888,10.1093/nar/gkaa299,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Phosphorothioate modified oligonucleotide-protein interactions.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Phosphorothioate modified oligonucleotide-protein interactions.
10928,40097,31164303,10.1016/j.vaccine.2019.05.076,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Phosphorothioated antisense oligodeoxynucleotide suppressing interleukin-10 is a safe and potent vaccine adjuvant.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phosphorothioated antisense oligodeoxynucleotide suppressing interleukin-10 is a safe and potent vaccine adjuvant.
10935,40104,41587091,10.1182/blood.2025029834,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Silencing of PAI-1 using siRNA-lipid nanoparticles reduces thrombosis and prolongs life span in murine models.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Silencing of PAI-1 using siRNA-lipid nanoparticles reduces thrombosis and prolongs life span in murine models.
10938,40107,41504091,10.31083/FBE44344,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic;dna damage,"toxicity candidate; matched derived terms: toxicity, toxic, dna damage; source title: Targeting the LRRK2 G2019S Mutation Found in Parkinson's Disease: Efficiency of Biosynthesized Solid Lipid Nanoparticles for Therapeutic siRNA-Mediated Gene Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting the LRRK2 G2019S Mutation Found in Parkinson's Disease: Efficiency of Biosynthesized Solid Lipid Nanoparticles for Therapeutic siRNA-Mediated Gene Therapy.
10953,40122,40736725,10.1021/acs.jmedchem.5c01269,offtarget,siRNA,PubMed abstract sentence 5,seed;mismatch;silencing,"offtarget candidate; matched derived terms: seed, mismatch, silencing; source title: Thermodynamic Destabilization and Structural Adaptability of 2'-Alkoxy/Fluoro- N 3 -Methyl Pyrimidine Nucleotides in siRNA Enhance RNA Interference Activity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Thermodynamic Destabilization and Structural Adaptability of 2'-Alkoxy/Fluoro-N(3)-Methyl Pyrimidine Nucleotides in siRNA Enhance RNA Interference Activity.
10954,40123,40736725,10.1021/acs.jmedchem.5c01269,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Thermodynamic Destabilization and Structural Adaptability of 2'-Alkoxy/Fluoro- N 3 -Methyl Pyrimidine Nucleotides in siRNA Enhance RNA Interference Activity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Thermodynamic Destabilization and Structural Adaptability of 2'-Alkoxy/Fluoro-N(3)-Methyl Pyrimidine Nucleotides in siRNA Enhance RNA Interference Activity.
10959,40128,40473123,10.1016/j.nbd.2025.106986,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.
10967,40136,40015110,10.1016/j.bioorg.2025.108299,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: On the interaction of anticancer G-quadruplex ligands with GalNAc-functionalized G-quadruplex-forming carriers for selective recognition and treatment of hepatocellular carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,On the interaction of anticancer G-quadruplex ligands with GalNAc-functionalized G-quadruplex-forming carriers for selective recognition and treatment of hepatocellular carcinoma.
10972,40141,39732226,10.1016/j.ijbiomac.2024.139186,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense oligonucleotides-based approaches for the treatment of multiple myeloma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense oligonucleotides-based approaches for the treatment of multiple myeloma.
10974,40143,39692702,10.1111/jocd.16722,toxicity,siRNA,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: A Novel Injectable Polypeptide Nanoparticle Encapsulated siRNA Targeting TGF-β1 and COX-2 for Localized Fat Reduction II: Phase I Clinical Trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Novel Injectable Polypeptide Nanoparticle Encapsulated siRNA Targeting TGF-β1 and COX-2 for Localized Fat Reduction II: Phase I Clinical Trial.
10977,40146,39379106,10.1261/rna.080220.124,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Site-blocking antisense oligonucleotides as a mechanism to fine-tune MeCP2 expression.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Site-blocking antisense oligonucleotides as a mechanism to fine-tune MeCP2 expression.
10992,40161,38779336,10.1016/j.omtm.2024.101258,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles.
10997,40166,38363779,10.1371/journal.pone.0298815,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluation of the anti-cancer efficacy of lipid nanoparticles containing siRNA against HPV16 E6/E7 combined with cisplatin in a xenograft model of cervical cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluation of the anti-cancer efficacy of lipid nanoparticles containing siRNA against HPV16 E6/E7 combined with cisplatin in a xenograft model of cervical cancer.
10998,40167,38276948,10.1152/ajpheart.00745.2023,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: An antisense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An antisense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo.
10999,40168,38246315,10.1016/j.cpcardiol.2024.102419,toxicity,siRNA,PubMed abstract sentence 9,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Inclisiran siRNA technology in the management of dyslipidemia: A narrative review of clinical trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inclisiran siRNA technology in the management of dyslipidemia: A narrative review of clinical trials.
11021,40190,36587552,10.1016/j.bmc.2022.117149,offtarget,ASO,PubMed abstract sentence 6,hybridization;silencing,"offtarget candidate; matched derived terms: hybridization, silencing; source title: Synthesis and biophysical properties of tetravalent PEG-conjugated antisense oligonucleotide.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synthesis and biophysical properties of tetravalent PEG-conjugated antisense oligonucleotide.
11023,40192,36464336,10.1016/j.pestbp.2022.105281,toxicity,siRNA,PubMed abstract sentence 11,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: New insights into transmission pathways and possible off-target effects of insecticidal dsRNA released by treated plants.",B,high_candidate,curator_rejected,reject,derived_annotations_only,New insights into transmission pathways and possible off-target effects of insecticidal dsRNA released by treated plants.
11031,40200,35042440,10.1177/01926233211063831,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense Oligonucleotide-Related Macrovesicular Vacuolation of Hippocampal Neurons in Nonhuman Primates.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense Oligonucleotide-Related Macrovesicular Vacuolation of Hippocampal Neurons in Nonhuman Primates.
11032,40201,34949835,10.1038/s41591-021-01557-6,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide.
11033,40202,34921096,10.1124/dmd.121.000751,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense Oligonucleotide In Vitro Protein Binding Determination in Plasma, Brain, and Cerebral Spinal Fluid Using Hybridization LC-MS/MS.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Antisense Oligonucleotide In Vitro Protein Binding Determination in Plasma, Brain, and Cerebral Spinal Fluid Using Hybridization LC-MS/MS."
11039,40208,34224372,10.1158/0008-5472.CAN-21-0953,offtarget,siRNA,PubMed abstract sentence 4,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: The Ratio of Toxic-to-Nontoxic miRNAs Predicts Platinum Sensitivity in Ovarian Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Ratio of Toxic-to-Nontoxic miRNAs Predicts Platinum Sensitivity in Ovarian Cancer.
11052,40221,30988454,10.1038/s41598-019-42523-0,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Systematic evaluation of 2'-Fluoro modified chimeric antisense oligonucleotide-mediated exon skipping in vitro.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Systematic evaluation of 2'-Fluoro modified chimeric antisense oligonucleotide-mediated exon skipping in vitro.
11057,40226,29268195,10.1016/j.jpba.2017.12.027,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development and validation of a bioanalytical method for quantification of LNA-i-miR-221, a 13-mer oligonucleotide, in rat plasma using LC-MS/MS.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Development and validation of a bioanalytical method for quantification of LNA-i-miR-221, a 13-mer oligonucleotide, in rat plasma using LC-MS/MS."
11058,40227,28988714,10.1016/j.ymthe.2017.09.015,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Genome-wide Mapping of Off-Target Events in Single-Stranded Oligodeoxynucleotide-Mediated Gene Repair Experiments.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Genome-wide Mapping of Off-Target Events in Single-Stranded Oligodeoxynucleotide-Mediated Gene Repair Experiments.
11059,40228,30970855,10.3390/polym9050177,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice.
11061,40230,28799823,10.1089/nat.2017.0676,toxicity,ASO,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Lack of QT Prolongation for 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Lack of QT Prolongation for 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects.
11063,40232,27557584,10.1007/978-1-4939-3795-0_16,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Quantitative Microinjection of Morpholino Antisense Oligonucleotides into Mouse Oocytes to Examine Gene Function in Meiosis-I.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Quantitative Microinjection of Morpholino Antisense Oligonucleotides into Mouse Oocytes to Examine Gene Function in Meiosis-I.
11067,40236,26855051,10.1016/j.jconrel.2016.02.007,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides."
11070,40239,26338776,10.1093/nar/gkv857,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.
11073,40242,26042553,10.1021/acs.nanolett.5b00490,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.
11075,40244,25350581,10.1038/mtna.2014.57,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease.
11078,40247,24211663,10.1016/j.vascn.2013.10.005,toxicity,ASO,PubMed abstract sentence 12,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies."
11085,40254,20615897,10.1093/nar/gkq457,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.
11086,40255,19533419,10.1007/s12032-009-9254-4,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Treatment of prostate and breast tumors employing mono- and bi-specific antisense oligonucleotides targeting apoptosis inhibitory proteins clusterin and bcl-2.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Treatment of prostate and breast tumors employing mono- and bi-specific antisense oligonucleotides targeting apoptosis inhibitory proteins clusterin and bcl-2.
11108,40277,40015870,10.1016/j.pestbp.2024.106278,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Insecticidal activity of two Pelargonium essential oils and head transcriptome analysis of stored-product pest Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) in response to citronellyl formate fumigation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Insecticidal activity of two Pelargonium essential oils and head transcriptome analysis of stored-product pest Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) in response to citronellyl formate fumigation.
11124,40293,35692770,10.3389/fonc.2022.854023,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Epirubicin Enhances the Anti-Cancer Effects of Radioactive 125 I Seeds in Hepatocellular Carcinoma via Downregulation of the JAK/STAT1 Pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Epirubicin Enhances the Anti-Cancer Effects of Radioactive (125)I Seeds in Hepatocellular Carcinoma via Downregulation of the JAK/STAT1 Pathway.
11127,40296,32786803,10.1021/jacs.0c04928,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents.
11131,40300,32002328,10.7717/peerj.8371,toxicity,siRNA,PubMed abstract sentence 1,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: The effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) on the transcriptome of aryl hydrocarbon receptor (AhR) knock-down porcine granulosa cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the transcriptome of aryl hydrocarbon receptor (AhR) knock-down porcine granulosa cells."
11133,40302,31034558,10.1093/nar/gkz247,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.
11136,40305,25711235,10.1093/toxsci/kfv043,toxicity,ASO,PubMed abstract sentence 1,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Re-evaluation of the Mutagenic Response to Phosphorothioate Nucleotides in Human Lymphoblastoid TK6 Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Re-evaluation of the Mutagenic Response to Phosphorothioate Nucleotides in Human Lymphoblastoid TK6 Cells.
11150,40319,42037220,10.1021/acsinfecdis.6c00095,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Rational Design and Screening of Chemically Modified Anti-SARS-CoV-2 siRNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Rational Design and Screening of Chemically Modified Anti-SARS-CoV-2 siRNA.
11155,40324,41989324,10.1039/d5bm01877c,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Supramolecular RNAi with multifunctional siRNA nanostructures.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Supramolecular RNAi with multifunctional siRNA nanostructures.
11156,40325,41959436,10.64898/2026.03.31.715590,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses.
11192,40361,41644074,10.1016/j.ijpharm.2026.126654,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gene silencing meets chemotherapy: A dual topical strategy using lipid nanoparticles against squamous cell carcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Gene silencing meets chemotherapy: A dual topical strategy using lipid nanoparticles against squamous cell carcinoma.
11193,40362,41640357,10.1021/acs.jcim.5c02636,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Constant-pH Molecular Dynamics of Cationic Peptide Dendrimers Binding to siRNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Constant-pH Molecular Dynamics of Cationic Peptide Dendrimers Binding to siRNA.
11197,40366,41607694,10.21769/BioProtoc.5567,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Highly Efficient siRNA Transfection Method in Primary Cultured Cortical Neurons.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Highly Efficient siRNA Transfection Method in Primary Cultured Cortical Neurons.
11199,40368,41599186,10.3390/pharmaceutics18010078,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cell-Penetrating Peptide-Mediated siRNA Targeting of LDHC Suppresses Tumor Growth in a Triple-Negative Breast Cancer Zebrafish Xenograft Model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cell-Penetrating Peptide-Mediated siRNA Targeting of LDHC Suppresses Tumor Growth in a Triple-Negative Breast Cancer Zebrafish Xenograft Model.
11204,40373,41572432,10.1002/advs.202510547,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites.
11216,40385,41508960,10.2174/0118715206395359251031081557,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Drug Release, Entrapment Efficacy, and Drug Loading Capacity of Taxanes Loaded Solid Lipid Nanoparticles (SLNs).",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Drug Release, Entrapment Efficacy, and Drug Loading Capacity of Taxanes Loaded Solid Lipid Nanoparticles (SLNs)."
11220,40389,41453463,10.1016/j.ijpharm.2025.126532,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A quality by design strategy to develop curcumin and siRNA co-loaded lipoplexes to target osteoarthritis-related inflammation and oxidative stress.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A quality by design strategy to develop curcumin and siRNA co-loaded lipoplexes to target osteoarthritis-related inflammation and oxidative stress.
11222,40391,41443351,10.1016/j.jconrel.2025.114568,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Structurally-defined non-cationic docosahexaenoic acid based siRNA-micelles for safe and effective combinatorial glioblastoma therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Structurally-defined non-cationic docosahexaenoic acid based siRNA-micelles for safe and effective combinatorial glioblastoma therapy.
11235,40404,41314050,10.1016/j.intimp.2025.115938,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preparation and in vitro functional validation of a novel antibody-siRNA-Exatecan conjugate (AREC).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Preparation and in vitro functional validation of a novel antibody-siRNA-Exatecan conjugate (AREC).
11255,40424,41599118,10.3390/pharmaceutics18010010,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Construction and Characterization of PDA@MnO 2 -Cored Multifunctional Targeting Nanoparticles Loaded with Survivin siRNA for Breast Tumor Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Construction and Characterization of PDA@MnO(2)-Cored Multifunctional Targeting Nanoparticles Loaded with Survivin siRNA for Breast Tumor Therapy.
11258,40427,41476668,10.1155/ijcb/6663816,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Important Aspects of siRNA Design for Optimal Efficacy In Vitro and In Vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Important Aspects of siRNA Design for Optimal Efficacy In Vitro and In Vivo.
11259,40428,41473322,10.64898/2025.12.16.694641,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system.
11262,40431,41432033,10.1093/nar/gkaf1374,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs.
11273,40442,41326382,10.1038/s41467-025-66876-5,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: An RNA interference therapeutic potentially achieves functional cure of chronic hepatitis B virus infection.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An RNA interference therapeutic potentially achieves functional cure of chronic hepatitis B virus infection.
11278,40447,41241375,10.1016/j.drudis.2025.104543,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: siRNA-based Nanocarriers for Targeted Therapy in Prostate Cancer: Implications for Male Fertility Preservation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA-based Nanocarriers for Targeted Therapy in Prostate Cancer: Implications for Male Fertility Preservation.
11279,40448,41239436,10.1186/s13071-025-07113-2,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNA interference mediated mortality in Aedes albopictus: a challenging journey toward species-specific vector control.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RNA interference mediated mortality in Aedes albopictus: a challenging journey toward species-specific vector control.
11294,40463,41155154,10.3390/ijms26209861,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNA Interference and Its Key Targets for Spinal Cord Injury Therapy: What Is Known So Far?",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA Interference and Its Key Targets for Spinal Cord Injury Therapy: What Is Known So Far?
11299,40468,41107628,10.1007/s00438-025-02303-0,offtarget,ASO,PubMed abstract sentence 7,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Making sense of carbonic anhydrase function in zebrafish using antisense morpholinos.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Making sense of carbonic anhydrase function in zebrafish using antisense morpholinos.
11300,40469,41096791,10.3390/ijms26199526,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Targeting carA Using Optimized Antisense Peptide Nucleic Acid-Cell-Penetrating Peptide Conjugates in Acinetobacter baumannii : A Novel Antibacterial Approach.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting carA Using Optimized Antisense Peptide Nucleic Acid-Cell-Penetrating Peptide Conjugates in Acinetobacter baumannii: A Novel Antibacterial Approach.
11303,40472,41064251,10.3389/fmicb.2025.1660799,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense phosphorodiamidate morpholino oligomers retain activity in Burkholderia cepacia complex biofilm.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense phosphorodiamidate morpholino oligomers retain activity in Burkholderia cepacia complex biofilm.
11305,40474,41030277,10.1002/btm2.70021,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Engineered lung cell targeting and SLC7A11 siRNA expressing bacterial extracellular vesicles impair the progression of none-small cell lung cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Engineered lung cell targeting and SLC7A11 siRNA expressing bacterial extracellular vesicles impair the progression of none-small cell lung cancer.
11310,40479,40943389,10.3390/ijms26178467,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: AS1411 Aptamer-Conjugated Liposomal siRNA Targeting MTA2 Suppresses PI3K/AKT Signaling in Pancreatic Cancer Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,AS1411 Aptamer-Conjugated Liposomal siRNA Targeting MTA2 Suppresses PI3K/AKT Signaling in Pancreatic Cancer Cells.
11314,40483,40939831,10.1016/j.jinsphys.2025.104884,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Recent progress in nanoparticle-mediated RNA interference in insects: Unveiling new frontiers in pest control.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Recent progress in nanoparticle-mediated RNA interference in insects: Unveiling new frontiers in pest control.
11316,40485,40927452,10.3389/fmicb.2025.1641192,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: siRNA-Silencing of swnR gene greatly reduced biosynthesis of swainsonine in Alternaria oxytropis without affecting the growth characteristics of leguminous host.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,siRNA-Silencing of swnR gene greatly reduced biosynthesis of swainsonine in Alternaria oxytropis without affecting the growth characteristics of leguminous host.
11321,40490,40907899,10.1016/j.ejps.2025.107252,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In vitro/in vivo evaluation of 3D bioprinted silk fibroin hydrogels for IBD: A dual mesalazine and TNF-α siRNA approach.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In vitro/in vivo evaluation of 3D bioprinted silk fibroin hydrogels for IBD: A dual mesalazine and TNF-α siRNA approach.
11325,40494,40873646,10.1002/EXP.20230178,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhanced Blood-Brain Barrier Penetrability of BACE1 SiRNA-Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Enhanced Blood-Brain Barrier Penetrability of BACE1 SiRNA-Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy.
11327,40496,40872836,10.3390/v17081122,offtarget,siRNA,PubMed abstract sentence 6,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: First Complete Genome Sequence of Palo Verde Broom Emaravirus, Virus-Derived siRNA Signatures, and Phytohormone-Metabolite Profiling of Witches' Broom-Affected Palo Verde Trees.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"First Complete Genome Sequence of Palo Verde Broom Emaravirus, Virus-Derived siRNA Signatures, and Phytohormone-Metabolite Profiling of Witches' Broom-Affected Palo Verde Trees."
11329,40498,40860190,10.7150/ijbs.109637,offtarget,siRNA,PubMed abstract sentence 4,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: siRNA as a criterion in host immunity and cancer immunotherapy: modulating factors and nano-conjugate based approach for intervention.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA as a criterion in host immunity and cancer immunotherapy: modulating factors and nano-conjugate based approach for intervention.
11340,40509,40736236,10.1128/spectrum.02622-24,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: An antisense peptide-conjugated peptide nucleic acid (PPNA) for peptidoglycan recycling inhibition reduces AmpC hyperproduction and β-lactam resistance in Pseudomonas aeruginosa .",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An antisense peptide-conjugated peptide nucleic acid (PPNA) for peptidoglycan recycling inhibition reduces AmpC hyperproduction and β-lactam resistance in Pseudomonas aeruginosa.
11348,40517,40679089,10.1021/acs.biomac.5c00344,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cleavable Cationic Carbosilane Dendrimers with pH-Tunable Charge as siRNA Carriers.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cleavable Cationic Carbosilane Dendrimers with pH-Tunable Charge as siRNA Carriers.
11351,40520,40667291,10.1101/2025.06.24.661398,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice.
11359,40528,40598893,10.1093/nar/gkaf600,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.
11373,40542,40516518,10.1016/j.medj.2025.100746,toxicity,siRNA,PubMed abstract sentence 2,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: siRNAs targeting ANGPTL3 for mixed dyslipidemia.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNAs targeting ANGPTL3 for mixed dyslipidemia.
11375,40544,40482915,10.1016/j.mbs.2025.109476,offtarget,siRNA,PubMed abstract sentence 1,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Stochastic model of siRNA endosomal escape mediated by fusogenic peptides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Stochastic model of siRNA endosomal escape mediated by fusogenic peptides.
11380,40549,40457499,10.1186/s40035-025-00486-5,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson's disease cell model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson's disease cell model.
11386,40555,40407475,10.3390/mps8030048,toxicity,ASO,PubMed abstract sentence 9,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Empagliflozin Repurposing for Lafora Disease: A Pilot Clinical Trial and Preclinical Investigation of Novel Therapeutic Targets.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Empagliflozin Repurposing for Lafora Disease: A Pilot Clinical Trial and Preclinical Investigation of Novel Therapeutic Targets.
11403,40572,40311353,10.1016/j.bioelechem.2025.108994,offtarget,siRNA,PubMed abstract sentence 4,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Effective targeting of E2F1 transcription factor via siRNA gene electrotransfer in HT-29 colorectal carcinoma xenografts.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Effective targeting of E2F1 transcription factor via siRNA gene electrotransfer in HT-29 colorectal carcinoma xenografts.
11405,40574,40306576,10.1016/j.jconrel.2025.113790,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Formulation of siRNA nanoparticles, transfection and enhanced adhesion -penetration in nasal mucosal tissue.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Formulation of siRNA nanoparticles, transfection and enhanced adhesion -penetration in nasal mucosal tissue."
11409,40578,40265933,10.3390/plants14060977,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Integrating RNA Interference and Nanotechnology: A Transformative Approach in Plant Protection.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Integrating RNA Interference and Nanotechnology: A Transformative Approach in Plant Protection.
11411,40580,40259913,10.2147/IJN.S511655,toxicity,siRNA,PubMed abstract sentence 16,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: NIR-Triggered siRNA Release and Lysosomal Escape for Synergistic Photothermal Tumor Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,NIR-Triggered siRNA Release and Lysosomal Escape for Synergistic Photothermal Tumor Therapy.
11413,40582,40256168,10.1016/j.csbj.2025.03.034,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In Silico and In Vitro development of novel small interfering RNAs (siRNAs) to inhibit SARS-CoV-2.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In Silico and In Vitro development of novel small interfering RNAs (siRNAs) to inhibit SARS-CoV-2.
11418,40587,40175880,10.1007/978-1-0716-4394-5_18,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Robust Post-Insertion Method for the Preparation of Targeted Lipid Nanoparticles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Robust Post-Insertion Method for the Preparation of Targeted Lipid Nanoparticles.
11422,40591,40156152,10.1002/smll.202410146,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tumor-Selective Gene Therapy: Using Hairpin DNA Oligonucleotides to Trigger Cleavage of Target RNA by Endogenous flap endonuclease 1 (FEN 1) Highly Expressed in Tumor Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tumor-Selective Gene Therapy: Using Hairpin DNA Oligonucleotides to Trigger Cleavage of Target RNA by Endogenous flap endonuclease 1 (FEN 1) Highly Expressed in Tumor Cells.
11424,40593,40143003,10.3390/pharmaceutics17030339,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Analysis of Polymer/siRNA Nanoparticle Efficacy and Biocompatibility in 3D Air-Liquid Interface Culture Compared to 2D Cell Culture.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Analysis of Polymer/siRNA Nanoparticle Efficacy and Biocompatibility in 3D Air-Liquid Interface Culture Compared to 2D Cell Culture.
11432,40601,40081431,10.1016/j.ijpharm.2025.125463,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: siRNA-based Therapeutics in Hormone-driven Cancers: Advancements and benefits over conventional treatments.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA-based Therapeutics in Hormone-driven Cancers: Advancements and benefits over conventional treatments.
11443,40612,39978787,10.1021/acsnano.4c14969,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: siRNA-Encapsulated Biomimetic Liposomes Effectively Inhibit Tumor Cells' Hexosamine Biosynthesis Pathway for Attenuating Hyaluronan Barriers to Pancreatic Cancer Chemotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA-Encapsulated Biomimetic Liposomes Effectively Inhibit Tumor Cells' Hexosamine Biosynthesis Pathway for Attenuating Hyaluronan Barriers to Pancreatic Cancer Chemotherapy.
11445,40614,39906612,10.22038/ijbms.2024.81998.17744,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Nanomolecular silencing of TSC22D4 mRNA via a DNAsome-siRNA for enhancing insulin sensitization in hepatocytes.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Nanomolecular silencing of TSC22D4 mRNA via a DNAsome-siRNA for enhancing insulin sensitization in hepatocytes.
11446,40615,39878452,10.1002/chem.202404068,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Self-Assembly of Antisense DNA-Camptothecin Amphiphile into Glutathione-Responsive Nanoparticles for Combination Cancer Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Self-Assembly of Antisense DNA-Camptothecin Amphiphile into Glutathione-Responsive Nanoparticles for Combination Cancer Therapy.
11448,40617,39860035,10.3390/life15010095,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Novel Approach for In Vitro Testing and Hazard Evaluation of Nanoformulated RyR2-Targeting siRNA Drugs Using Human PBMCs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Novel Approach for In Vitro Testing and Hazard Evaluation of Nanoformulated RyR2-Targeting siRNA Drugs Using Human PBMCs.
11450,40619,39855282,10.1016/j.ijpharm.2025.125234,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Therapeutic potential of siRNA PMP22-SQ nanoparticles for Charcot-Marie-Tooth 1A neuropathy in rodents and non-human primates.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Therapeutic potential of siRNA PMP22-SQ nanoparticles for Charcot-Marie-Tooth 1A neuropathy in rodents and non-human primates.
11455,40624,39791575,10.1021/acsnano.4c15130,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhalable siRNA Targeting IL-11 Nanoparticles Significantly Inhibit Bleomycin-Induced Pulmonary Fibrosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Inhalable siRNA Targeting IL-11 Nanoparticles Significantly Inhibit Bleomycin-Induced Pulmonary Fibrosis.
11456,40625,39784355,10.1039/d4tb01954g,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Multi-functional near-infrared fluorescent polymer dot-siRNA for gene expression regulation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Multi-functional near-infrared fluorescent polymer dot-siRNA for gene expression regulation.
11458,40627,39733890,10.1016/j.ijbiomac.2024.139219,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Shielding siRNA by peptide-based nanofibers: An efficient approach for turning off EGFR gene in breast cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Shielding siRNA by peptide-based nanofibers: An efficient approach for turning off EGFR gene in breast cancer.
11460,40629,39723844,10.1021/acsabm.4c01319,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Application of Strontium Chloride Hexahydrate to Synthesize Strontium-Substituted Carbonate Apatite as a pH-Sensitive, Biologically Safe, and Highly Efficient siRNA Nanocarrier.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Application of Strontium Chloride Hexahydrate to Synthesize Strontium-Substituted Carbonate Apatite as a pH-Sensitive, Biologically Safe, and Highly Efficient siRNA Nanocarrier."
11464,40633,39663120,10.1136/gutjnl-2024-332597,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antiviral therapy for chronic hepatitis delta: new insights from clinical trials and real-life studies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antiviral therapy for chronic hepatitis delta: new insights from clinical trials and real-life studies.
11467,40636,39632755,10.4062/biomolther.2024.071,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Design, Screening and Development of Asymmetric siRNAs Targeting the MYC Oncogene in Triple-Negative Breast Cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Design, Screening and Development of Asymmetric siRNAs Targeting the MYC Oncogene in Triple-Negative Breast Cancer."
11471,40640,40308740,10.59566/isrnn.2024.0101079,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Reduction of Traumatic Spinal Cord Secondary Injury by Anti-RhoA siRNA Functionalized Nucleic Acid Nanoparticles (NANPs).",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The Reduction of Traumatic Spinal Cord Secondary Injury by Anti-RhoA siRNA Functionalized Nucleic Acid Nanoparticles (NANPs).
11481,40650,39454759,10.1016/j.antiviral.2024.106024,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: SiRNAs as antiviral drugs - Current status, therapeutic potential and challenges.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"SiRNAs as antiviral drugs - Current status, therapeutic potential and challenges."
11482,40651,39427257,10.1021/acsami.4c16869,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Metal Ion-Condensed DNA Nanoparticle Library: Phase Separation and Transition and Antisense Therapy Applications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Metal Ion-Condensed DNA Nanoparticle Library: Phase Separation and Transition and Antisense Therapy Applications.
11489,40658,39296267,10.1021/acsptsci.4c00336,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipopolymer/siRNA Nanoparticles Targeting the Signal Transducer and Activator of Transcription 5A Disrupts Proliferation of Acute Lymphoblastic Leukemia.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Lipopolymer/siRNA Nanoparticles Targeting the Signal Transducer and Activator of Transcription 5A Disrupts Proliferation of Acute Lymphoblastic Leukemia.
11490,40659,39276676,10.1016/j.neurot.2024.e00443,toxicity,ASO,PubMed abstract sentence 12,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Gene therapy for the leukodystrophies: From preclinical animal studies to clinical trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gene therapy for the leukodystrophies: From preclinical animal studies to clinical trials.
11496,40665,39189114,10.1089/nat.2024.0030,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Near Sequence Homology Does Not Guarantee siRNA Cross-Species Efficacy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Near Sequence Homology Does Not Guarantee siRNA Cross-Species Efficacy.
11502,40671,39098747,10.1016/j.ijpharm.2024.124545,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhancing siRNA cancer therapy: Multifaceted strategies with lipid and polymer-based carrier systems.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhancing siRNA cancer therapy: Multifaceted strategies with lipid and polymer-based carrier systems.
11506,40675,39045515,10.1016/j.omtn.2024.102256,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advancing cancer treatments: The role of oligonucleotide-based therapies in driving progress.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advancing cancer treatments: The role of oligonucleotide-based therapies in driving progress.
11520,40689,38672408,10.3390/biom14040390,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synthesis and Validation of TRIFAPYs as a Family of Transfection Agents for Therapeutic Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Synthesis and Validation of TRIFAPYs as a Family of Transfection Agents for Therapeutic Oligonucleotides.
11526,40695,38617800,10.2147/IJN.S443413,toxicity,siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Microdroplets Encapsulated with NFATc1-siRNA and Exosomes-Derived from MSCs Onto 3D Porous PLA Scaffold for Regulating Osteoclastogenesis and Promoting Osteogenesis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Microdroplets Encapsulated with NFATc1-siRNA and Exosomes-Derived from MSCs Onto 3D Porous PLA Scaffold for Regulating Osteoclastogenesis and Promoting Osteogenesis.
11528,40697,38613388,10.1093/nar/gkae260,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.
11539,40708,38458734,10.1016/bs.pmbts.2023.12.009,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNA interference-based therapies for atherosclerosis: Recent advances and future prospects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA interference-based therapies for atherosclerosis: Recent advances and future prospects.
11540,40709,38456415,10.1161/JAHA.123.032031,toxicity,ASO/siRNA,PubMed abstract sentence 7,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Harnessing RNA Interference for Cholesterol Lowering: The Bench-to-Bedside Story of Inclisiran.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Harnessing RNA Interference for Cholesterol Lowering: The Bench-to-Bedside Story of Inclisiran.
11542,40711,38426370,10.1002/jcph.2418,toxicity,siRNA,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Application of Model-Informed Drug Development in Dose Selection and Optimization for siRNA Therapies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Application of Model-Informed Drug Development in Dose Selection and Optimization for siRNA Therapies.
11548,40717,38330721,10.1016/j.bioorg.2024.107176,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Repurposing sodium stibogluconate as an uracil DNA glycosylase inhibitor against prostate cancer using a time-resolved oligonucleotide-based drug screening platform.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Repurposing sodium stibogluconate as an uracil DNA glycosylase inhibitor against prostate cancer using a time-resolved oligonucleotide-based drug screening platform.
11561,40730,38062661,10.2174/0113816128275065231103063935,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: An In-silico Approach to Design and Validate siRNA against Monkeypox Virus.",B,high_candidate,curator_rejected,reject,derived_annotations_only,An In-silico Approach to Design and Validate siRNA against Monkeypox Virus.
11563,40732,37948524,10.1126/sciadv.adf7997,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology.
11577,40746,37290591,10.1016/j.jhep.2023.05.023,offtarget,siRNA,PubMed abstract sentence 4,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials.
11583,40752,37073950,10.7554/eLife.85902,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS."
11591,40760,36834783,10.3390/ijms24043375,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review.
11597,40766,36611443,10.3390/diagnostics13010151,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Computational Design and Experimental Evaluation of MERS-CoV siRNAs in Selected Cell Lines.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Computational Design and Experimental Evaluation of MERS-CoV siRNAs in Selected Cell Lines.
11600,40769,36513186,10.1016/j.jhep.2022.11.025,toxicity,siRNA,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis."
11601,40770,36373781,10.1177/08853282221138922,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The complexing of cationic copolymer MPC 30 -DEA 70 with TGF-β1 antisense oligodeoxynucleotide and transfection into cardiomyocytes in vitro .",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The complexing of cationic copolymer MPC(30)-DEA(70) with TGF-β1 antisense oligodeoxynucleotide and transfection into cardiomyocytes in vitro.
11605,40774,36457549,10.2147/IJN.S383862,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Combined Self-Assembled iRGD Polymersomes for Effective Targeted siRNA Anti-Tumor Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Combined Self-Assembled iRGD Polymersomes for Effective Targeted siRNA Anti-Tumor Therapy.
11609,40778,36276652,10.7150/thno.77830,toxicity,siRNA,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Specificity of oligonucleotide gene therapy (OGT) agents.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Specificity of oligonucleotide gene therapy (OGT) agents.
11619,40788,35749736,10.1002/adhm.202200579,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aggregation-Induced Emission (AIE) and Magnetic Resonance Imaging Characteristics for Targeted and Image-Guided siRNA Therapy of Hepatocellular Carcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Aggregation-Induced Emission (AIE) and Magnetic Resonance Imaging Characteristics for Targeted and Image-Guided siRNA Therapy of Hepatocellular Carcinoma.
11624,40793,35537364,10.1016/j.compbiolchem.2022.107687,offtarget,siRNA,PubMed abstract sentence 7,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains.
11630,40799,35156491,10.1080/10717544.2022.2032874,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hyaluronic acid-modified redox-sensitive hybrid nanocomplex loading with siRNA for non-small-cell lung carcinoma therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hyaluronic acid-modified redox-sensitive hybrid nanocomplex loading with siRNA for non-small-cell lung carcinoma therapy.
11631,40800,35143189,10.1021/jacs.1c12750,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hairpin-like siRNA-Based Spherical Nucleic Acids.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hairpin-like siRNA-Based Spherical Nucleic Acids.
11632,40801,35107256,10.1021/acsabm.1c01182,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Complexing the Pre-assembled Brush-like siRNA with Poly(β-amino ester) for Efficient Gene Silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Complexing the Pre-assembled Brush-like siRNA with Poly(β-amino ester) for Efficient Gene Silencing.
11633,40802,35034590,10.2174/1389201023666220114160216,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Antisense Agents against Antibiotic-resistant Bacteria.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense Agents against Antibiotic-resistant Bacteria.
11637,40806,34652881,10.1002/anie.202110455,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Click Chemistry Approach to Targeted DNA Crosslinking with cis-Platinum(II)-Modified Triplex-Forming Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Click Chemistry Approach to Targeted DNA Crosslinking with cis-Platinum(II)-Modified Triplex-Forming Oligonucleotides.
11643,40812,34665651,10.1089/nat.2021.0061,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Effective Inhibition of Newly Emerged A/H7N9 Virus with Oligonucleotides Targeted to Conserved Regions of the Virus Genome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Effective Inhibition of Newly Emerged A/H7N9 Virus with Oligonucleotides Targeted to Conserved Regions of the Virus Genome.
11649,40818,34445782,10.3390/ijms22169080,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Combined Transcriptomic Analysis and RNA Interference Reveal the Effects of Methoxyfenozide on Ecdysone Signaling Pathway of Spodoptera exigua .",B,high_candidate,curator_rejected,reject,derived_annotations_only,Combined Transcriptomic Analysis and RNA Interference Reveal the Effects of Methoxyfenozide on Ecdysone Signaling Pathway of Spodoptera exigua.
11655,40824,33949380,10.1039/d0an02205e,toxicity,ASO,PubMed abstract sentence 7,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Highly sensitive MALDI-MS measurement of active ricin: insight from more potential deoxynucleobase-hybrid oligonucleotide substrates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Highly sensitive MALDI-MS measurement of active ricin: insight from more potential deoxynucleobase-hybrid oligonucleotide substrates.
11659,40828,33744469,10.1016/j.ymthe.2021.03.015,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo.
11673,40842,33375375,10.3390/ijms22010182,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Terminal Mono- and Bis-Conjugates of Oligonucleotides with Closo -Dodecaborate: Synthesis and Physico-Chemical Properties.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Terminal Mono- and Bis-Conjugates of Oligonucleotides with Closo-Dodecaborate: Synthesis and Physico-Chemical Properties.
11678,40847,32986398,10.1021/acs.bioconjchem.0c00444,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Internal Oligoguanidinium Transporter: Mercury-Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization, and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitization of Taxol in MCF-7 Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Internal Oligoguanidinium Transporter: Mercury-Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization, and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitization of Taxol in MCF-7 Cells."
11684,40853,32726663,10.1016/j.lfs.2020.118150,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib.
11686,40855,32597264,10.1080/03639045.2020.1788061,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of orally administered insulin-loaded polymeric-oligonucleotide nanoparticles: statistical optimization and physicochemical characterization.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of orally administered insulin-loaded polymeric-oligonucleotide nanoparticles: statistical optimization and physicochemical characterization.
11692,40861,31991801,10.3390/molecules25030525,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD.
11694,40863,31701435,10.1007/s40291-019-00434-w,toxicity,siRNA,PubMed abstract sentence 12,adverse;renal;hematological,"toxicity candidate; matched derived terms: adverse, renal, hematological; source title: Leading RNA Interference Therapeutics Part 1: Silencing Hereditary Transthyretin Amyloidosis, with a Focus on Patisiran.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Leading RNA Interference Therapeutics Part 1: Silencing Hereditary Transthyretin Amyloidosis, with a Focus on Patisiran."
11697,40866,31546749,10.3390/ijms20194700,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Efficient Epidermal Growth Factor Receptor Targeting Oligonucleotide as a Potential Molecule for Targeted Cancer Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficient Epidermal Growth Factor Receptor Targeting Oligonucleotide as a Potential Molecule for Targeted Cancer Therapy.
11698,40867,31509944,10.3390/molecules24183287,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase.
11699,40868,31501844,10.1039/c9cc05703j,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization.
11702,40871,31375812,10.1038/s41587-019-0205-0,offtarget,siRNA,PubMed abstract sentence 6,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
11703,40872,31375812,10.1038/s41587-019-0205-0,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
11704,40873,30917503,10.3390/molecules24061180,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Oligonucleotide⁻Palladacycle Conjugates as Splice-Correcting Agents.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Oligonucleotide⁻Palladacycle Conjugates as Splice-Correcting Agents.
11707,40876,30284504,10.1080/07391102.2018.1498390,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Structural insight into antisense gapmer-RNA oligomer duplexes through molecular dynamics simulations.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Structural insight into antisense gapmer-RNA oligomer duplexes through molecular dynamics simulations.
11708,40877,30388622,10.1016/j.omtn.2018.09.027,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids.
11712,40881,29461800,10.1021/acsinfecdis.7b00235,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense Inhibitors Retain Activity in Pulmonary Models of Burkholderia Infection.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense Inhibitors Retain Activity in Pulmonary Models of Burkholderia Infection.
11716,40885,29246291,10.1016/j.omtn.2017.09.006,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tween 85-Modified Low Molecular Weight PEI Enhances Exon-Skipping of Antisense Morpholino Oligomer In Vitro and in mdx Mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Tween 85-Modified Low Molecular Weight PEI Enhances Exon-Skipping of Antisense Morpholino Oligomer In Vitro and in mdx Mice.
11717,40886,28742140,10.1371/journal.pone.0181065,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Short (16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Short (16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes.
11718,40887,28334749,10.1093/nar/gkx111,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.
11719,40888,28274742,10.1016/j.jconrel.2017.03.004,offtarget,siRNA,PubMed abstract sentence 7,seed;mismatch;silencing,"offtarget candidate; matched derived terms: seed, mismatch, silencing; source title: A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis.
11720,40889,27351681,10.1038/mtna.2016.46,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice.
11722,40891,27327137,10.1038/mtna.2016.36,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates.
11724,40893,26944796,10.1016/j.biochi.2016.02.015,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells.
11725,40894,26923600,10.1016/j.celrep.2016.02.018,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases.
11728,40897,25911184,10.1007/s40265-015-0391-0,toxicity,ASO,PubMed abstract sentence 1,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Antisense approach to inflammatory bowel disease: prospects and challenges.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense approach to inflammatory bowel disease: prospects and challenges.
11729,40898,25197025,10.1002/jcph.396,toxicity,ASO,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: First proof of pharmacology in humans of a novel glucagon receptor antisense drug.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,First proof of pharmacology in humans of a novel glucagon receptor antisense drug.
11732,40901,24866718,10.1111/imb.12103,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Knockdown of mitogen-activated protein kinase (MAPK) signalling in the midgut of Anopheles stephensi mosquitoes using antisense morpholinos.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Knockdown of mitogen-activated protein kinase (MAPK) signalling in the midgut of Anopheles stephensi mosquitoes using antisense morpholinos.
11734,40903,24586944,10.1371/journal.pone.0089659,toxicity,ASO,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.
11735,40904,24511611,,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice.
11736,40905,24506227,10.1021/cb400875u,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides.
11737,40906,24380393,10.1089/nat.2013.0456,toxicity,ASO,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Study of CRTC2 pharmacology using antisense oligonuceotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Study of CRTC2 pharmacology using antisense oligonuceotides.
11741,40910,24085767,10.1182/blood-2013-04-499657,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense-based RNA therapy of factor V deficiency: in vitro and ex vivo rescue of a F5 deep-intronic splicing mutation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense-based RNA therapy of factor V deficiency: in vitro and ex vivo rescue of a F5 deep-intronic splicing mutation.
11743,40912,23982190,10.1038/mtna.2013.46,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier.
11747,40916,22852836,10.1089/nat.2012.0366,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chemical modification study of antisense gapmers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Chemical modification study of antisense gapmers.
11749,40918,22615794,10.1371/journal.pone.0036697,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Stable gene targeting in human cells using single-strand oligonucleotides with modified bases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Stable gene targeting in human cells using single-strand oligonucleotides with modified bases.
11751,40920,22149555,10.1089/jop.2011.0135,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Efficacy of a phosphorodiamidate morpholino oligomer antisense compound in the inhibition of corneal transplant rejection in a rat cornea transplant model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficacy of a phosphorodiamidate morpholino oligomer antisense compound in the inhibition of corneal transplant rejection in a rat cornea transplant model.
11752,40921,22058018,10.1007/s10059-011-0160-1,offtarget,siRNA,PubMed abstract sentence 4,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Selection and optimization of asymmetric siRNA targeting the human c-MET gene.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Selection and optimization of asymmetric siRNA targeting the human c-MET gene.
11754,40923,21179007,10.1038/mt.2010.288,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: One-year treatment of morpholino antisense oligomer improves skeletal and cardiac muscle functions in dystrophic mdx mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,One-year treatment of morpholino antisense oligomer improves skeletal and cardiac muscle functions in dystrophic mdx mice.
11757,40926,20886816,10.1021/ja105875e,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.
11790,40959,42206267,10.1155/humu/8545428,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PLSCR3 Deficiency Triggers mtDNA-Driven cGAS-STING Activation to Potentiate Antitumor Immunity in Colorectal Cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,PLSCR3 Deficiency Triggers mtDNA-Driven cGAS-STING Activation to Potentiate Antitumor Immunity in Colorectal Cancer.
11793,40962,42205761,10.3389/fonc.2026.1832247,toxicity,siRNA,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: LF3 exerts anti-osteosarcoma effects through Wnt signaling inhibition-coupled ferroptosis induction via HO-1/ACSL4 axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,LF3 exerts anti-osteosarcoma effects through Wnt signaling inhibition-coupled ferroptosis induction via HO-1/ACSL4 axis.
11796,40965,42204874,10.1080/1750743X.2026.2679883,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Beyond conventional therapies: immunotherapeutic strategies targeting HPV-associated cervical cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Beyond conventional therapies: immunotherapeutic strategies targeting HPV-associated cervical cancer.
11797,40966,42204714,10.1186/s40104-026-01380-4,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: METTL3 inhibition attenuates AFB 1 -induced hepatic fibrosis by suppressing m 6 A-mediated hepatic stellate cell activation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,METTL3 inhibition attenuates AFB(1)-induced hepatic fibrosis by suppressing m(6)A-mediated hepatic stellate cell activation.
11799,40968,42203536,10.1016/j.clinthera.2026.05.021,toxicity,ASO,PubMed abstract sentence 16,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Advancements in Prenatal Diagnosis and Potential Fetal Therapies for Spinal Muscular Atrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advancements in Prenatal Diagnosis and Potential Fetal Therapies for Spinal Muscular Atrophy.
11820,40989,42191889,10.1038/s41434-026-00620-6,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Characterization of CAR-T cell factors that contribute to myeloid cell activation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Characterization of CAR-T cell factors that contribute to myeloid cell activation.
11827,40996,42190515,10.1016/j.biomaterials.2026.124335,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoparticles-mediated dual metabolic-immunological intervention reverses immunosuppression in muscle invasive bladder cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanoparticles-mediated dual metabolic-immunological intervention reverses immunosuppression in muscle invasive bladder cancer.
11862,41031,42177070,10.1016/bs.apcsb.2026.02.010,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aptamers as immunomodulatory therapeutic alternatives targeting neglected tropical diseases (NTDs).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamers as immunomodulatory therapeutic alternatives targeting neglected tropical diseases (NTDs).
11864,41033,42176944,10.1016/j.envres.2026.124828,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Benzophenone-2 disrupts craniofacial cartilage development via esr2a-Dependent inhibition of endothelin signaling in zebrafish larvae.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Benzophenone-2 disrupts craniofacial cartilage development via esr2a-Dependent inhibition of endothelin signaling in zebrafish larvae.
11866,41035,42176919,10.1016/j.ijbiomac.2026.152671,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bif-1 upregulates autophagy to improve nitrite tolerance of Litopenaeus vannamei by interacts with Prohibitin-2.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Bif-1 upregulates autophagy to improve nitrite tolerance of Litopenaeus vannamei by interacts with Prohibitin-2.
11868,41037,42176843,10.1016/j.tox.2026.154505,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: ALDH1A3-dependent ferroptosis mediates hexafluoropropylene oxide dimer acid-induced trophoblast dysfunction.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,ALDH1A3-dependent ferroptosis mediates hexafluoropropylene oxide dimer acid-induced trophoblast dysfunction.
11872,41041,42173265,10.1016/j.fsi.2026.111441,offtarget,siRNA,PubMed abstract sentence 9,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Study on the function of HIF-1α in the infection of Penaeus vannamei by Vibrio parahaemolyticus.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Study on the function of HIF-1α in the infection of Penaeus vannamei by Vibrio parahaemolyticus.
11885,41054,42166816,10.1016/j.ejmech.2026.118944,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Design, synthesis, and biological evaluation of 2-morpholino-4H-chromen-4-one derivatives as a potent dual PI3K/BRD4 inhibitors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Design, synthesis, and biological evaluation of 2-morpholino-4H-chromen-4-one derivatives as a potent dual PI3K/BRD4 inhibitors."
11890,41059,42164918,10.1186/s44477-026-00026-z,toxicity,siRNA,PubMed abstract sentence 7,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Toward nanomedicine-enabled RNA therapeutics for Alzheimer's disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Toward nanomedicine-enabled RNA therapeutics for Alzheimer's disease.
11895,41064,42164311,10.3389/dyst.2026.14631,offtarget,ASO/siRNA,PubMed abstract sentence 5,off-target;unintended,"offtarget candidate; matched derived terms: off-target, unintended; source title: Validation of a torsinA cerebellar knockdown model of DYT1 dystonia.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Validation of a torsinA cerebellar knockdown model of DYT1 dystonia.
11896,41065,42163668,10.2174/011570159X441441260318061159,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanomedicine Strategies for Overcoming Temozolomide Resistance in Glioblastoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanomedicine Strategies for Overcoming Temozolomide Resistance in Glioblastoma.
11906,41075,42159076,10.1002/bcp.70573,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Precision medicine in paediatrics: Progress and priorities.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Precision medicine in paediatrics: Progress and priorities.
11921,41090,42153502,10.1021/acsabm.5c02297,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Unraveling the Multifunctional and Translational Paradigm of Nanoparticulate Systems against Colorectal Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Unraveling the Multifunctional and Translational Paradigm of Nanoparticulate Systems against Colorectal Cancer.
11937,41106,42143999,10.1016/j.placenta.2026.05.009,toxicity,siRNA,PubMed abstract sentence 1,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: In vitro fertilization-associated osteomodulin upregulation is linked to impaired placental angiogenesis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In vitro fertilization-associated osteomodulin upregulation is linked to impaired placental angiogenesis.
11942,41111,42140388,10.1016/j.jconrel.2026.115025,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Non-viral strategies for transfection of the corneal endothelium.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Non-viral strategies for transfection of the corneal endothelium.
11961,41130,42131106,10.3389/fcell.2026.1781550,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RBX1 loss sensitizes tubo-ovarian, high-grade serous ovarian cells to CDK2 inhibition by SNS-032.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"RBX1 loss sensitizes tubo-ovarian, high-grade serous ovarian cells to CDK2 inhibition by SNS-032."
11962,41131,42130075,10.1002/bcp.70577,toxicity,siRNA,PubMed abstract sentence 4,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Decoding RNA regulation: Challenges and opportunities for RNA-based therapies in Europe.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Decoding RNA regulation: Challenges and opportunities for RNA-based therapies in Europe.
11967,41136,42128555,10.1016/j.aca.2026.345564,toxicity,ASO,PubMed abstract sentence 1,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: A smartphone-integrated portable fluorescent biosensor for on-site detection of antibiotics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A smartphone-integrated portable fluorescent biosensor for on-site detection of antibiotics.
11969,41138,42128122,10.1016/j.ijbiomac.2026.152490,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification and validation of UDP-glycosyltransferase genes associated with lambda-cyhalothrin resistance in Cydia pomonella.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identification and validation of UDP-glycosyltransferase genes associated with lambda-cyhalothrin resistance in Cydia pomonella.
11973,41142,42124655,10.64898/2026.02.24.707669,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Testing vivo-morpholino mediated gene knockdown in threespine stickleback.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Testing vivo-morpholino mediated gene knockdown in threespine stickleback.
11985,41154,42117494,10.1002/ardp.70250,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Designing Telomerase Inhibitors for Cancer Therapy: Mechanistic Insights, Medicinal Chemistry Strategies, Challenges, and Future Directions.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Designing Telomerase Inhibitors for Cancer Therapy: Mechanistic Insights, Medicinal Chemistry Strategies, Challenges, and Future Directions."
12000,41169,42108271,10.1038/s41591-026-04408-4,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: The microRNA inhibitor CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction: a randomized phase 2 trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The microRNA inhibitor CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction: a randomized phase 2 trial.
12024,41193,42099136,10.2174/0115665232415170251130041834,toxicity,ASO,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hutchinson-Gilford Progeria Syndrome: Genetic Insights, Clinical Challenges, and Innovative Therapeutic Approaches.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Hutchinson-Gilford Progeria Syndrome: Genetic Insights, Clinical Challenges, and Innovative Therapeutic Approaches."
12026,41195,42098773,10.1186/s12951-026-04450-x,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Tumor-targeted liposomal RNAi therapy suppresses breast cancer and modulates tumor microenvironment.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Tumor-targeted liposomal RNAi therapy suppresses breast cancer and modulates tumor microenvironment.
12041,41210,42090855,10.1016/j.saa.2026.128020,toxicity,ASO/siRNA,PubMed abstract sentence 1,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: A novel fluorescent aptasensor for sensitive and label-free detection of Di(2-ethylhexyl) phthalate based on catalytic hairpin assembly-assisted CRISPR/Cas9 and G-triplex.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A novel fluorescent aptasensor for sensitive and label-free detection of Di(2-ethylhexyl) phthalate based on catalytic hairpin assembly-assisted CRISPR/Cas9 and G-triplex.
12056,41225,42076851,10.1002/jat.70234,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: TFEB Attenuates Silver Nanoparticle-Induced Pulmonary Ferroptosis by Preserving Lysosomal Integrity and Limiting Iron Dysregulation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,TFEB Attenuates Silver Nanoparticle-Induced Pulmonary Ferroptosis by Preserving Lysosomal Integrity and Limiting Iron Dysregulation.
12059,41228,42076082,10.3390/pharmaceutics18040431,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNA Therapeutics in Viral Infections and Cancer: Mechanisms, Challenges, and Prospects: A Review.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"RNA Therapeutics in Viral Infections and Cancer: Mechanisms, Challenges, and Prospects: A Review."
12065,41234,42072483,10.3390/biomedicines14040943,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Single Cell and Bulk RNA-Seq Profiling of Non-Metastatic Versus Bone-Metastatic Prostate Cancer Identifies the CXCL10-CXCR3 Axis as a Key Determinant of Tumor Microenvironment and Treatment Resistance.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Single Cell and Bulk RNA-Seq Profiling of Non-Metastatic Versus Bone-Metastatic Prostate Cancer Identifies the CXCL10-CXCR3 Axis as a Key Determinant of Tumor Microenvironment and Treatment Resistance.
12069,41238,42070528,10.1016/j.ecoenv.2026.120128,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bisphenol S induces lipid metabolic disruption associated with SREBP signaling in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bisphenol S induces lipid metabolic disruption associated with SREBP signaling in Caenorhabditis elegans.
12072,41241,42068897,10.1016/j.intimp.2026.116771,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sweroside ameliorates endothelial dysfunction via the KLF2-mediated repression of the FABP4/CCL20 signaling axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sweroside ameliorates endothelial dysfunction via the KLF2-mediated repression of the FABP4/CCL20 signaling axis.
12077,41246,42067490,10.1053/j.seminhematol.2026.03.012,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Diagnosis and management of hematologic malignancies in the context of telomere biology disorders.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Diagnosis and management of hematologic malignancies in the context of telomere biology disorders.
12089,41258,42060212,10.1007/s12672-026-05086-x,toxicity,ASO/siRNA,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A patient-derived organoid model identifies TP53-dependent gemcitabine sensitivity in spinal chordoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A patient-derived organoid model identifies TP53-dependent gemcitabine sensitivity in spinal chordoma.
12106,41275,42046304,10.1111/pce.70568,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The MdERF1B-MdWRKY75-MdSOS3 Module Confers Salt Tolerance by Regulating Sodium-Potassium Homoeostasis in Apple.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The MdERF1B-MdWRKY75-MdSOS3 Module Confers Salt Tolerance by Regulating Sodium-Potassium Homoeostasis in Apple.
12107,41276,42045911,10.1186/s12929-026-01246-x,toxicity,siRNA,PubMed abstract sentence 16,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans.
12141,41310,42024108,10.1021/acs.bioconjchem.5c00653,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lipidated Aminoglycosides as New Tools that Repurpose Old Natural Antibiotics for New-Fangled Utility.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipidated Aminoglycosides as New Tools that Repurpose Old Natural Antibiotics for New-Fangled Utility.
12144,41313,42022287,10.3389/fmolb.2026.1775335,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Emerging roles of PIWI-interacting RNAs in cancer molecular diagnostics and therapeutics: a molecular biosciences perspective.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Emerging roles of PIWI-interacting RNAs in cancer molecular diagnostics and therapeutics: a molecular biosciences perspective.
12153,41322,42015182,10.1186/s13073-026-01659-1,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Comparative genomics identifies small interfering RNA with activity against all five human betacoronaviruses.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comparative genomics identifies small interfering RNA with activity against all five human betacoronaviruses.
12160,41329,42013544,10.1016/j.redox.2026.104180,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nrf2 pathway mediates copper oxide nanoparticle-induced exacerbation of allergic asthma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Nrf2 pathway mediates copper oxide nanoparticle-induced exacerbation of allergic asthma.
12163,41332,42010649,10.1186/s12951-026-04334-0,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Cu-based metal-organic framework based on desloratadine and siHIF-1α for achievement of genes/drugs/CDT combination therapy in hepatocellular carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Cu-based metal-organic framework based on desloratadine and siHIF-1α for achievement of genes/drugs/CDT combination therapy in hepatocellular carcinoma.
12167,41336,42007882,10.1096/fj.202600387RRR,toxicity,ASO/siRNA,PubMed abstract sentence 13,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair.
12169,41338,42007566,10.1021/acs.molpharmaceut.5c01868,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Smart Magnetic Nanozyme for Multimodal Dynamic Regulation to Reverse Multidrug Resistance in Breast Cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Smart Magnetic Nanozyme for Multimodal Dynamic Regulation to Reverse Multidrug Resistance in Breast Cancer.
12191,41360,41996987,10.1016/j.bbrc.2026.153723,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Decoding RNA splicing pathology: Alternative splicing in amyotrophic lateral sclerosis and its therapeutic potential.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Decoding RNA splicing pathology: Alternative splicing in amyotrophic lateral sclerosis and its therapeutic potential.
12192,41361,41996792,10.1016/j.ecoenv.2026.120154,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Di-(2-ethylhexyl) phthalate induces spermatogenic dysfunction via p38/NCOA4-dependent ferritinophagy and ferroptosis in Sertoli cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Di-(2-ethylhexyl) phthalate induces spermatogenic dysfunction via p38/NCOA4-dependent ferritinophagy and ferroptosis in Sertoli cells.
12200,41369,41991930,10.1038/s41420-026-03055-5,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Uttroside B, a US FDA-designated 'Orphan Drug', mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Uttroside B, a US FDA-designated 'Orphan Drug', mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3."
12224,41393,41977511,10.3390/ijms27073336,toxicity,ASO,PubMed abstract sentence 4,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Factor XII in Thrombosis and Thromboinflammation: From Molecular Biology to Clinical Translation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Factor XII in Thrombosis and Thromboinflammation: From Molecular Biology to Clinical Translation.
12227,41396,41976277,10.3390/cancers18071054,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pleuromutilins Suppress Hepatocellular Carcinoma Growth via ABCA1 Inhibition-Induced Cholesterol Accumulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pleuromutilins Suppress Hepatocellular Carcinoma Growth via ABCA1 Inhibition-Induced Cholesterol Accumulation.
12229,41398,41972720,10.3390/cells15070632,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Diagnostic and Therapeutic Applications of Exosomes in Lung Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Diagnostic and Therapeutic Applications of Exosomes in Lung Cancer.
12238,41407,41967235,10.1016/j.phymed.2026.158143,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Betulinic acid induces lysosome-dependent death in prostate cancer by targeting DDX5.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Betulinic acid induces lysosome-dependent death in prostate cancer by targeting DDX5.
12243,41412,41964044,10.1186/s40360-026-01116-0,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lycopene attenuates DEHP-induced oxidative stress, mitochondrial dysfunction, and apoptosis in human granulosa cells via SIRT1-dependent mechanisms.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Lycopene attenuates DEHP-induced oxidative stress, mitochondrial dysfunction, and apoptosis in human granulosa cells via SIRT1-dependent mechanisms."
12249,41418,41962730,10.1016/j.actbio.2026.04.008,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Carrier-free spherical nucleic acids engineered by coordination-competition for programmable release and cancer immunotherapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Carrier-free spherical nucleic acids engineered by coordination-competition for programmable release and cancer immunotherapy.
12254,41423,41961051,10.57264/cer-2025-0108,toxicity,ASO/siRNA,PubMed abstract sentence 7,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Advancements from the EVOLVE study for assessing real-world experience with eteplirsen, golodirsen and casimersen for the treatment of DMD.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Advancements from the EVOLVE study for assessing real-world experience with eteplirsen, golodirsen and casimersen for the treatment of DMD."
12257,41426,41957221,10.1007/s13346-026-02110-z,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Rational design of lipid-based nanoparticles for targeted anticancer therapies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rational design of lipid-based nanoparticles for targeted anticancer therapies.
12258,41427,41957177,10.1007/s12094-026-04348-y,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted and molecular therapies in Ewing sarcoma: a comprehensive review of preclinical and clinical advances.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted and molecular therapies in Ewing sarcoma: a comprehensive review of preclinical and clinical advances.
12259,41428,41956485,10.1002/jat.70186,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Vps34 Knockdown Alleviated the Long-Term Effect of Nano-Alumina on Cognitive Impairment in Zebrafish When in Embryos.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Vps34 Knockdown Alleviated the Long-Term Effect of Nano-Alumina on Cognitive Impairment in Zebrafish When in Embryos.
12260,41429,41956481,10.1667/RADE-25-00117.1,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Apigenin Enhances the Radiosensitivity of TNBC Cells by Improving cGAS-STING Pathway Activity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Apigenin Enhances the Radiosensitivity of TNBC Cells by Improving cGAS-STING Pathway Activity.
12261,41430,41954302,10.1002/adhm.202505296,offtarget,siRNA,PubMed abstract sentence 11,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Multitalented Hybrid Targeted Nanoconstructs Selectively Repress Survival Genes and Induce Breast Tumor Regression In Vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Multitalented Hybrid Targeted Nanoconstructs Selectively Repress Survival Genes and Induce Breast Tumor Regression In Vivo.
12267,41436,41950730,10.1016/j.phymed.2026.158146,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Characterization of cyclotide Vdif A from Viola diffusa inhibits non-small cell lung cancer cells via regulation of CKS2.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Characterization of cyclotide Vdif A from Viola diffusa inhibits non-small cell lung cancer cells via regulation of CKS2.
12276,41445,41942863,10.1186/s12860-026-00586-8,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chemoradiotherapy-induced Th17/IL-17 signaling correlates with therapeutic tolerance and early recurrence in cervical carcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chemoradiotherapy-induced Th17/IL-17 signaling correlates with therapeutic tolerance and early recurrence in cervical carcinoma.
12292,41461,41932596,10.1016/j.yexcr.2026.115007,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Zn 2+ -dependent modulation of the mitochondrial Ca 2+ uniporter underlies resveratrol-mediated protection against myocardial ischemia-reperfusion injury.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Zn(2+)-dependent modulation of the mitochondrial Ca(2+) uniporter underlies resveratrol-mediated protection against myocardial ischemia-reperfusion injury.
12294,41463,41932066,10.1016/j.dnarep.2026.103934,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxic;dna damage,"toxicity candidate; matched derived terms: toxic, dna damage; source title: Single-cell transcriptomics reveal PRRC1 as a malignant cell enriched driver of DNA repair and therapy resistance in glioblastoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Single-cell transcriptomics reveal PRRC1 as a malignant cell enriched driver of DNA repair and therapy resistance in glioblastoma.
12295,41464,41930872,10.1016/j.intimp.2026.116524,toxicity,ASO/siRNA,PubMed abstract sentence 18,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Serine mediates protection against calcium oxalate nephrolithiasis by attenuating tubular epithelial cell apoptosis through the SDSL-IDH2 axis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Serine mediates protection against calcium oxalate nephrolithiasis by attenuating tubular epithelial cell apoptosis through the SDSL-IDH2 axis.
12316,41485,41919648,10.1002/adma.202523584,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Disrupting KAT8 Liquid-Liquid Phase Separation with Hybrid Vesicle-Liposome Platform for Enhanced PD-L1 Blockade Treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Disrupting KAT8 Liquid-Liquid Phase Separation with Hybrid Vesicle-Liposome Platform for Enhanced PD-L1 Blockade Treatment.
12322,41491,41913928,10.7717/peerj.20902,toxicity,ASO/siRNA,PubMed abstract sentence 2,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Evidence from a broad-range PNA probe links several Prevotella species to bacterial vaginosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evidence from a broad-range PNA probe links several Prevotella species to bacterial vaginosis.
12332,41501,41910152,10.1080/03639045.2026.2624601,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Stimuli-responsive mesoporous silica nanoparticles for brain tumor theranostics and drug targeting.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Stimuli-responsive mesoporous silica nanoparticles for brain tumor theranostics and drug targeting.
12345,41514,41899661,10.3390/ijerph23030284,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Validation of Analytical Methodology for Glyphosate Determination and Degradation Assessment with the Silver Arsenate Photocatalyst.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Validation of Analytical Methodology for Glyphosate Determination and Degradation Assessment with the Silver Arsenate Photocatalyst.
12356,41525,41897502,10.3390/antiox15030356,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Dimercaprol Reprograms Intestinal Redox Homeostasis and Organelle Crosstalk to Combat Iron-Induced Gut Dysbiosis Through NRF2/HO-1 Signaling.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Dimercaprol Reprograms Intestinal Redox Homeostasis and Organelle Crosstalk to Combat Iron-Induced Gut Dysbiosis Through NRF2/HO-1 Signaling.
12359,41528,41897346,10.3390/biom16030410,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Licochalcone A as a Potential Anti- Toxoplasma Agent: A Target Identification and Pharmacokinetic Study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Licochalcone A as a Potential Anti-Toxoplasma Agent: A Target Identification and Pharmacokinetic Study.
12364,41533,41894086,10.1007/s11033-026-11713-1,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Porphyromonas gingivalis-derived lipopolysaccharide confers chemotherapy resistance and migratory ability on oral cancer cells by activating toll-like receptor 4 signaling pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Porphyromonas gingivalis-derived lipopolysaccharide confers chemotherapy resistance and migratory ability on oral cancer cells by activating toll-like receptor 4 signaling pathway.
12365,41534,41893522,10.3390/toxics14030254,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: 6-PPD Quinone Inhibits Phosphatidic Acid Synthesis Associated with an Increase in Intestinal Barrier Permeability in C. elegans .",B,high_candidate,curator_rejected,reject,derived_annotations_only,6-PPD Quinone Inhibits Phosphatidic Acid Synthesis Associated with an Increase in Intestinal Barrier Permeability in C. elegans.
12369,41538,41890811,10.1093/bioadv/vbag075,offtarget,siRNA,PubMed abstract sentence 3,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: SIREN: suite for intelligent RNAi design and evaluation of nucleotide sequences.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SIREN: suite for intelligent RNAi design and evaluation of nucleotide sequences.
12377,41546,41887755,10.1021/acs.jafc.5c14284,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Metabolic Assays and RNAi-Based Functional Characterization of the P450 Gene CYP6AQ1 under Environmental Stress in Apis cerana cerana .",B,high_candidate,curator_rejected,reject,derived_annotations_only,Metabolic Assays and RNAi-Based Functional Characterization of the P450 Gene CYP6AQ1 under Environmental Stress in Apis cerana cerana.
12400,41569,41876350,10.1016/j.jacl.2026.02.021,toxicity,siRNA,PubMed abstract sentence 7,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Dyslipidemia and therapies after heart transplantation: Current evidence and future directions.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dyslipidemia and therapies after heart transplantation: Current evidence and future directions.
12403,41572,41876006,10.1016/j.bbadis.2026.168229,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Securinine suppresses pancreatic cancer progression by activating the p38 MAPK pathway to upregulate CHOP and induce endoplasmic reticulum stress.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Securinine suppresses pancreatic cancer progression by activating the p38 MAPK pathway to upregulate CHOP and induce endoplasmic reticulum stress.
12418,41587,41869406,10.2147/IJN.S551541,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Filamentous Phage for Therapeutic Applications in Non-Small Cell Lung Cancer and Brain Metastases: Recent Prospect.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Filamentous Phage for Therapeutic Applications in Non-Small Cell Lung Cancer and Brain Metastases: Recent Prospect.
12422,41591,41869201,10.7759/cureus.103877,toxicity,siRNA,PubMed abstract sentence 9,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: RNA-Based Therapies for Hypercholesterolemia and Coronary Artery Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA-Based Therapies for Hypercholesterolemia and Coronary Artery Disease.
12423,41592,41868680,10.62347/KRNB3973,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of RAB7 promotes CD8 + T cell activation via the STING/IRF1/CCL5/CXCL10 signaling axis to promote PD-1-mediated anti-lung cancer efficacy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of RAB7 promotes CD8(+) T cell activation via the STING/IRF1/CCL5/CXCL10 signaling axis to promote PD-1-mediated anti-lung cancer efficacy.
12426,41595,41866005,10.1016/j.jep.2026.121554,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8 + cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.
12433,41602,41861874,10.1016/j.ijbiomac.2026.151533,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Functional characterization of MsFE4 in the detoxification metabolism of Melanaphis sacchari to nitenpyram.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Functional characterization of MsFE4 in the detoxification metabolism of Melanaphis sacchari to nitenpyram.
12434,41603,41861112,10.1002/advs.202515849,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Embedded CRISPRi Enhances Gene-Silencing Efficiency in Drosophila.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Embedded CRISPRi Enhances Gene-Silencing Efficiency in Drosophila.
12438,41607,41858835,10.1016/j.omtn.2026.102874,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: c-Jun in neurodegeneration: A key transcriptional regulator with therapeutic implications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,c-Jun in neurodegeneration: A key transcriptional regulator with therapeutic implications.
12439,41608,41857757,10.1093/neuonc/noag057,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RAC1 Regulates SHH-Medulloblastoma Growth via GLI-Mediated Transcription.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RAC1 Regulates SHH-Medulloblastoma Growth via GLI-Mediated Transcription.
12451,41620,41853625,10.14252/foodsafetyfscj.D-25-00017,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Immunochromatography Test Kit for Paralytic Shellfish Toxins (PSTs) and Transition of PSTs in Scallops.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Immunochromatography Test Kit for Paralytic Shellfish Toxins (PSTs) and Transition of PSTs in Scallops.
12454,41623,41852107,10.1111/bph.70407,toxicity,ASO,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin-degrading enzyme, a new molecular vulnerability in multiple myeloma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin-degrading enzyme, a new molecular vulnerability in multiple myeloma."
12455,41624,41851979,10.1021/acs.jafc.6c01702,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: α-Lipoic Acid Activates the Nrf2/HO-1 Pathway to Ameliorate Arsenic-Induced Multiorgan Oxidative Damage.",B,high_candidate,curator_rejected,reject,derived_annotations_only,α-Lipoic Acid Activates the Nrf2/HO-1 Pathway to Ameliorate Arsenic-Induced Multiorgan Oxidative Damage.
12463,41632,41847637,10.1021/acsmedchemlett.5c00723,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Serial PNA-Transformer-Based Virtual Screening Identifies Nanomolar DYRK1A Inhibitors for Pancreatic Ductal Adenocarcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Serial PNA-Transformer-Based Virtual Screening Identifies Nanomolar DYRK1A Inhibitors for Pancreatic Ductal Adenocarcinoma.
12474,41643,41842655,10.1096/fj.202503735RR,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Penicillide Triggers Immunogenic Pyroptosis in Tumor Cells via Oxidative Stress/NF-κB/GSDMD Signaling Axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Penicillide Triggers Immunogenic Pyroptosis in Tumor Cells via Oxidative Stress/NF-κB/GSDMD Signaling Axis.
12476,41645,41842091,10.1364/AO.580699,toxicity,ASO,PubMed abstract sentence 1,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: AuNP-enhanced DNA microcavity for the highly sensitive detection of lead ions in Chinese herbal medicines.",B,high_candidate,curator_rejected,reject,derived_annotations_only,AuNP-enhanced DNA microcavity for the highly sensitive detection of lead ions in Chinese herbal medicines.
12481,41650,41839477,10.1016/j.carres.2026.109893,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Fucoidan-based nanoparticles for colorectal cancer therapy: Mechanisms and preclinical insights.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Fucoidan-based nanoparticles for colorectal cancer therapy: Mechanisms and preclinical insights.
12484,41653,41839309,10.1016/j.ejps.2026.107503,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preclinical validation of tetrahydroquinoline derivatives as EGFR inhibitor inducing glioblastoma cell death.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preclinical validation of tetrahydroquinoline derivatives as EGFR inhibitor inducing glioblastoma cell death.
12488,41657,41837787,10.1097/CRD.0000000000001248,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Calcineurin-Nuclear Factor of Activated T Cells Signaling Axis in Hypertrophic Cardiomyopathy: Molecular Insights and Therapeutic Implications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Calcineurin-Nuclear Factor of Activated T Cells Signaling Axis in Hypertrophic Cardiomyopathy: Molecular Insights and Therapeutic Implications.
12489,41658,41836750,10.1093/biomethods/bpag014,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: One size does not fit all: A comparative framework for optimizing ribonucleic acid transfection across acute myeloid leukemia cell lines.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,One size does not fit all: A comparative framework for optimizing ribonucleic acid transfection across acute myeloid leukemia cell lines.
12499,41668,41833037,10.2174/0118715273418647251208093957,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pharmacological Breakthroughs with Extracellular Vesicles-Based Nanomedicine: A Targeted Strategy to Cross the Blood-Brain Barrier in Alzheimer's Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pharmacological Breakthroughs with Extracellular Vesicles-Based Nanomedicine: A Targeted Strategy to Cross the Blood-Brain Barrier in Alzheimer's Disease.
12506,41675,41831864,10.1016/j.pestbp.2026.106996,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Clothianidin resistance in field populations of Nilaparvata lugens Stål.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Clothianidin resistance in field populations of Nilaparvata lugens Stål.
12508,41677,41831862,10.1016/j.pestbp.2026.106985,toxicity,siRNA,PubMed abstract sentence 1,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: Identification and functional analysis of a double-stranded ribonuclease influencing RNAi efficiency in the striped flea beetle, Phyllotreta striolata.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Identification and functional analysis of a double-stranded ribonuclease influencing RNAi efficiency in the striped flea beetle, Phyllotreta striolata."
12509,41678,41831738,10.1016/j.jep.2026.121525,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Quercetin enhances skin flap survival via SIRT1-regulated mitophagy promotion and pyroptosis inhibition.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Quercetin enhances skin flap survival via SIRT1-regulated mitophagy promotion and pyroptosis inhibition.
12514,41683,41829820,10.3390/plants15050789,offtarget,siRNA,PubMed abstract sentence 11,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Wheat miR408 and miR159 Weaken the Virulence of Parastagonospora nodorum (Berk.) and Induce the Defense Response in Plants ( Triticum aestivum L.) Against Pathogens.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Wheat miR408 and miR159 Weaken the Virulence of Parastagonospora nodorum (Berk.) and Induce the Defense Response in Plants (Triticum aestivum L.) Against Pathogens.
12521,41690,41821425,10.1080/21678421.2026.2638589,toxicity,ASO,PubMed abstract sentence 8,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Tofersen treatment in SOD1 p.Leu145Phe ALS: real-world outcomes in a genetically homogeneous Croatian cohort.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Tofersen treatment in SOD1 p.Leu145Phe ALS: real-world outcomes in a genetically homogeneous Croatian cohort.
12524,41693,41820318,10.2174/0118715206398665251010093110,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aptamers in Osteosarcoma: New Paths for Diagnosis and Treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamers in Osteosarcoma: New Paths for Diagnosis and Treatment.
12525,41694,41818944,10.1016/j.phymed.2026.158029,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Huaier-derived arnicolide D induces ferroptosis in gastric cancer via SRC/TNF-mediated GPX4 inactivation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Huaier-derived arnicolide D induces ferroptosis in gastric cancer via SRC/TNF-mediated GPX4 inactivation.
12536,41705,41809875,10.3748/wjg.v32.i8.113299,toxicity,ASO,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance.
12542,41711,41806608,10.1016/j.bioorg.2026.109710,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Red-light-activated and thermally-stable amido-dithienylethenes for the reversible control of G-quadruplex binding and anticancer activity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Red-light-activated and thermally-stable amido-dithienylethenes for the reversible control of G-quadruplex binding and anticancer activity.
12554,41723,41800803,10.1002/ame2.70157,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1-mediated macrophage polarization via the PI3K/Akt pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1-mediated macrophage polarization via the PI3K/Akt pathway.
12555,41724,41800264,10.7150/ijbs.122898,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination."
12557,41726,41799736,10.1093/hr/uhaf325,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The bile acid sodium symporter SlBASS4 enhances tomato salt tolerance.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The bile acid sodium symporter SlBASS4 enhances tomato salt tolerance.
12571,41740,41789800,10.5152/eurasianjmed.2026.251350,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Small Interfering RNA Strategies to Overcome Drug Resistance in Cancer: Pathway Targeting and Translational Advances.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Small Interfering RNA Strategies to Overcome Drug Resistance in Cancer: Pathway Targeting and Translational Advances.
12573,41742,41788214,10.3389/fpls.2026.1738805,offtarget,siRNA,PubMed abstract sentence 4,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: Metabolic engineering of soybean for improving grain quality for animal consumption.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Metabolic engineering of soybean for improving grain quality for animal consumption.
12577,41746,41785402,10.1021/acs.jafc.5c15523,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Plant-Derived Isoferulic Acid and RNAi Synergize to Overcome Detoxification Defenses in the Bird Cherry-Oat Aphid ( Rhopalosiphum padi ).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Plant-Derived Isoferulic Acid and RNAi Synergize to Overcome Detoxification Defenses in the Bird Cherry-Oat Aphid (Rhopalosiphum padi).
12592,41761,41775321,10.1016/j.jare.2026.02.051,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: From scaffold to effector: reframing GFAP in neurodegeneration.",B,high_candidate,curator_rejected,reject,derived_annotations_only,From scaffold to effector: reframing GFAP in neurodegeneration.
12593,41762,41775213,10.1016/j.phymed.2026.157949,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Neveskin from Ferula samarcandica exerts anti-gastric cancer effects via the Hippo-YAP signaling pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Neveskin from Ferula samarcandica exerts anti-gastric cancer effects via the Hippo-YAP signaling pathway.
12598,41767,41770616,10.1097/FJC.0000000000001815,toxicity,ASO/siRNA,PubMed abstract sentence 6,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: The Multifaceted Role of Angiopoietin-Like Proteins in Coronary Heart Disease: From Molecular Mechanisms to Clinical Translation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Multifaceted Role of Angiopoietin-Like Proteins in Coronary Heart Disease: From Molecular Mechanisms to Clinical Translation.
12600,41769,41767175,10.2147/JAA.S592079,toxicity,ASO,PubMed abstract sentence 6,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Donidalorsen for Long-Term Prophylaxis of Hereditary Angioedema Attacks: Results from the OASISplus Open-Label Extension Cohort at Year 1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Donidalorsen for Long-Term Prophylaxis of Hereditary Angioedema Attacks: Results from the OASISplus Open-Label Extension Cohort at Year 1.
12622,41791,41744751,10.3390/bios16020133,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Rapid Detection of Fumonisin B1 Using a Fluorescent Aptasensor with Plasmon-Modified Graphene Oxide as a Quencher.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rapid Detection of Fumonisin B1 Using a Fluorescent Aptasensor with Plasmon-Modified Graphene Oxide as a Quencher.
12631,41800,41737559,10.3389/fphar.2026.1761502,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Minnelide ameliorates Col4a5+/- mice by upregulating Col4a5 and alleviating endoplasmic reticulum stress.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Minnelide ameliorates Col4a5+/- mice by upregulating Col4a5 and alleviating endoplasmic reticulum stress.
12638,41807,41730837,10.1038/s41389-026-00602-8,offtarget,siRNA,PubMed abstract sentence 5,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Human papillomavirus16 E7 enhances cell stemness by regulating the APC2/SPIN4/β-catenin axis in cervical cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Human papillomavirus16 E7 enhances cell stemness by regulating the APC2/SPIN4/β-catenin axis in cervical cancer.
12645,41814,41721069,10.1007/s11095-026-04034-2,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted Gene Therapy for Mutated H-ras and C-raf.1 Genes Exhibited Variable Efficacy in Inhibiting Hepatocellular Carcinoma in Rats: A Mechanistic Approach.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeted Gene Therapy for Mutated H-ras and C-raf.1 Genes Exhibited Variable Efficacy in Inhibiting Hepatocellular Carcinoma in Rats: A Mechanistic Approach.
12656,41825,41713751,10.1016/j.neuro.2026.103409,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Endoplasmic reticulum stress-induced CHOP activation mediates NLRP3 inflammasome-dependent pyroptosis in BDE-47-induced cognitive dysfunction.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Endoplasmic reticulum stress-induced CHOP activation mediates NLRP3 inflammasome-dependent pyroptosis in BDE-47-induced cognitive dysfunction.
12661,41830,41707964,10.1016/j.mcn.2026.104074,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: 4-MEC potentially triggers CAV1 via the BDNF-TrkB signaling pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,4-MEC potentially triggers CAV1 via the BDNF-TrkB signaling pathway.
12669,41838,41699675,10.1186/s13046-026-03670-1,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: IKBKE downregulation increases chemosensitivity through pyroptosis mediated by the caspase-3/GSDME pathway in pancreatic cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,IKBKE downregulation increases chemosensitivity through pyroptosis mediated by the caspase-3/GSDME pathway in pancreatic cancer.
12671,41840,41697089,10.1021/acs.jafc.5c15898,toxicity,siRNA,PubMed abstract sentence 7,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Targeting Co-Safe RNAi Genes: Identification of Chitin Synthase and β-1,3-Glucanase for Sustainable Control of the Invasive Pest Tuta absoluta .",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Targeting Co-Safe RNAi Genes: Identification of Chitin Synthase and β-1,3-Glucanase for Sustainable Control of the Invasive Pest Tuta absoluta."
12679,41848,41686281,10.1007/s10571-026-01695-w,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory Conditions.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory Conditions.
12688,41857,41682351,10.3390/s26030836,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Simultaneous Down-Regulation of Intracellular hTERT and GPX4 mRNA Using MnO 2 -Nanosheet Probes to Induce Cancer Cell Death.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Simultaneous Down-Regulation of Intracellular hTERT and GPX4 mRNA Using MnO(2)-Nanosheet Probes to Induce Cancer Cell Death.
12708,41877,41661214,10.1001/jamaneurol.2025.4946,toxicity,ASO,PubMed abstract sentence 4,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Long-Term Tofersen in SOD1 Amyotrophic Lateral Sclerosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Long-Term Tofersen in SOD1 Amyotrophic Lateral Sclerosis.
12713,41882,41659641,10.64898/2026.01.26.701790,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: CMTM6-Silencing Microbial Immunotherapy Reprograms PDAC Tumors and Restores T-cell Function.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CMTM6-Silencing Microbial Immunotherapy Reprograms PDAC Tumors and Restores T-cell Function.
12716,41885,41655780,10.1016/j.lfs.2026.124259,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Drug repurposing reveals Fmoc-l-leucine as an adipose thermogenesis activator in cold-exposed mice by targeting PPARγ/UCP1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Drug repurposing reveals Fmoc-l-leucine as an adipose thermogenesis activator in cold-exposed mice by targeting PPARγ/UCP1.
12726,41895,41649705,10.1186/s11671-026-04450-8,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoparticle approaches for hepatitis therapy and clinical translation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanoparticle approaches for hepatitis therapy and clinical translation.
12728,41897,41648544,10.64898/2026.01.16.700033,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart."
12730,41899,41646189,10.3389/fphar.2026.1706103,toxicity,siRNA,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gingerenone A attenuates diabetic vascular remodeling through AMPK/mTOR/S6K1 signaling.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gingerenone A attenuates diabetic vascular remodeling through AMPK/mTOR/S6K1 signaling.
12732,41901,41645864,10.1002/adhm.202600013,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Spatiotemporally Cascade-Releasing Polyester Nanoparticles for Synergistic Photodynamic/Chemo/Gene Therapy of Colorectal Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Spatiotemporally Cascade-Releasing Polyester Nanoparticles for Synergistic Photodynamic/Chemo/Gene Therapy of Colorectal Cancer.
12745,41914,41630990,10.1016/j.omtn.2026.102834,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Improving angiogenesis ameliorates the efficacy of ASO-based exon skipping for the treatment of Duchenne muscular dystrophy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Improving angiogenesis ameliorates the efficacy of ASO-based exon skipping for the treatment of Duchenne muscular dystrophy.
12757,41926,41628993,10.1016/j.pestbp.2025.106919,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transferrin confers imidacloprid resistance by attenuating ROS-induced apoptotic signaling in the white-backed planthopper, Sogatella furcifera.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Transferrin confers imidacloprid resistance by attenuating ROS-induced apoptotic signaling in the white-backed planthopper, Sogatella furcifera."
12766,41935,41619555,10.1016/j.phymed.2026.157869,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Isoginkgetin inhibits non-small cell lung cancer by inducing oxidative stress and regulating M1 macrophage polarization.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Isoginkgetin inhibits non-small cell lung cancer by inducing oxidative stress and regulating M1 macrophage polarization.
12769,41938,41617419,10.21873/anticanres.17975,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synergistic Effects of Honokiol on Camptothecin-triggered Apoptosis of Drug-resistant Glioblastoma Cells via CDK1-mediated G 2 /M Arrest and Intrinsic ROS-Mitochondrion-dependent Pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Synergistic Effects of Honokiol on Camptothecin-triggered Apoptosis of Drug-resistant Glioblastoma Cells via CDK1-mediated G(2)/M Arrest and Intrinsic ROS-Mitochondrion-dependent Pathway.
12783,41952,41601463,10.1097/MNH.0000000000001163,toxicity,siRNA,PubMed abstract sentence 6,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: New pharmacological therapies for hypertension.",B,high_candidate,curator_rejected,reject,derived_annotations_only,New pharmacological therapies for hypertension.
12788,41957,41599191,10.3390/pharmaceutics18010084,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Rewriting Tumor Entry Rules: Microfluidic Polyplexes and Tumor-Penetrating Strategies-A Literature Review.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rewriting Tumor Entry Rules: Microfluidic Polyplexes and Tumor-Penetrating Strategies-A Literature Review.
12790,41959,41598970,10.3390/insects17010116,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Effects of Sublethal Concentrations of Pyridaben on Development, Reproduction, and Vg Gene Expression in Neoseiulus womersleyi .",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Effects of Sublethal Concentrations of Pyridaben on Development, Reproduction, and Vg Gene Expression in Neoseiulus womersleyi."
12792,41961,41598920,10.3390/insects17010066,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CarE1 and GST1 Are Involved in Beta-Cypermethrin Resistance in Field Populations of the Mirid Bug, Apolygus lucorum .",B,high_candidate,curator_rejected,reject,derived_annotations_only,"CarE1 and GST1 Are Involved in Beta-Cypermethrin Resistance in Field Populations of the Mirid Bug, Apolygus lucorum."
12794,41963,41596643,10.3390/ijms27020997,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Defining the Critical Role of α-Gustducin for NF-κB Inhibition and Anti-Inflammatory Signal Transduction by Bitter Agonists in Lung Epithelium.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Defining the Critical Role of α-Gustducin for NF-κB Inhibition and Anti-Inflammatory Signal Transduction by Bitter Agonists in Lung Epithelium.
12795,41964,41596567,10.3390/ijms27020921,toxicity,ASO,PubMed abstract sentence 8,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Angiopoietin-like Protein 3 (ANGPTL3) Targeting in the Management of Dyslipidemias.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Angiopoietin-like Protein 3 (ANGPTL3) Targeting in the Management of Dyslipidemias.
12816,41985,41582000,10.1002/ptr.70220,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Celastrol Targets Hsc70-Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis.
12818,41987,41581265,10.1016/j.ceca.2026.103119,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: BDNF prevents amyloid-β-induced exacerbation of mGluR5-driven Ca 2+ transients in astrocytes through TrkB-Tc activation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,BDNF prevents amyloid-β-induced exacerbation of mGluR5-driven Ca(2+) transients in astrocytes through TrkB-Tc activation.
12828,41997,41578369,10.1186/s12964-026-02669-7,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Reprogramming the epigenetic profile improves the B regulatory cell function of patients with recurrent pregnancy loss.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Reprogramming the epigenetic profile improves the B regulatory cell function of patients with recurrent pregnancy loss.
12839,42008,41568168,10.1016/j.omtn.2025.102813,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Enhancement of therapeutic transgene insertion for treatment of murine phenylketonuria.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Enhancement of therapeutic transgene insertion for treatment of murine phenylketonuria.
12845,42014,41564474,10.1016/j.intimp.2026.116202,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MAP3K19 promotes the progression of hypopharyngeal cancer by suppressing dendritic cell maturation through mediating NF-κB activation and PD-L1 expression.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,MAP3K19 promotes the progression of hypopharyngeal cancer by suppressing dendritic cell maturation through mediating NF-κB activation and PD-L1 expression.
12847,42016,41562251,10.1002/advs.202517895,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells.
12854,42023,41558278,10.1016/j.ecoenv.2026.119767,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exposure to 77PD quinone inhibits longevity and healthspan via affecting mitochondrial signals in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exposure to 77PD quinone inhibits longevity and healthspan via affecting mitochondrial signals in Caenorhabditis elegans.
12867,42036,41548790,10.1016/j.ijbiomac.2026.150303,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PSMA RNA aptamer A10-3.2 conjugated with indocyanine green for rapid intraoperative imaging and effective mild photothermal therapy of prostate cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,PSMA RNA aptamer A10-3.2 conjugated with indocyanine green for rapid intraoperative imaging and effective mild photothermal therapy of prostate cancer.
12871,42040,41548376,10.1016/j.ejphar.2026.178563,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PEGylated cerium oxide nanoparticles alleviate osteoarthritis progression by inhibiting chondrocyte ferroptosis and maintaining cartilage homeostasis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,PEGylated cerium oxide nanoparticles alleviate osteoarthritis progression by inhibiting chondrocyte ferroptosis and maintaining cartilage homeostasis.
12875,42044,41545030,10.1002/jcsm.70171,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Mitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Mitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation.
12888,42057,41528411,10.1007/s10735-025-10712-z,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Sevoflurane-induced ferroptosis in developing neurons mediated by the NCOA4-ferritinophagy-GPX4 pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sevoflurane-induced ferroptosis in developing neurons mediated by the NCOA4-ferritinophagy-GPX4 pathway.
12890,42059,41527135,10.1186/s13046-025-03613-2,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Low expression of ALOX15B modulates immunosuppressive tumor microenvironment in diffuse large B-cell lymphoma via the TAP1/MHC-I axis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Low expression of ALOX15B modulates immunosuppressive tumor microenvironment in diffuse large B-cell lymphoma via the TAP1/MHC-I axis.
12894,42063,41520142,10.1093/neuonc/noaf300,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic;dna damage,"toxicity candidate; matched derived terms: toxicity, toxic, dna damage; source title: SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeres.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeres.
12901,42070,41512040,10.1073/pnas.2507065123,offtarget,ASO,PubMed abstract sentence 5,off-target;mismatch,"offtarget candidate; matched derived terms: off-target, mismatch; source title: A pothole-filling strategy for selective targeting of rCUG-repeats associated with myotonic dystrophy type 1.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A pothole-filling strategy for selective targeting of rCUG-repeats associated with myotonic dystrophy type 1.
12902,42071,41510801,10.1002/mc.70074,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: HMGB1 Assists in Overcoming Cisplatin Resistance in Chemoresistant Human Ovarian Cancer Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,HMGB1 Assists in Overcoming Cisplatin Resistance in Chemoresistant Human Ovarian Cancer Cells.
12905,42074,41508018,10.1186/s12951-025-03974-y,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Microglia-derived iron-overloaded exosomes induce neuronal ferroptosis and aggravate neurological impairment after subarachnoid hemorrhage.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Microglia-derived iron-overloaded exosomes induce neuronal ferroptosis and aggravate neurological impairment after subarachnoid hemorrhage.
12906,42075,41507895,10.1186/s12885-026-15540-2,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: β-ionone synergizes with 5-Fluorouracil to inhibit gastric cancer progression through PAX6-mediated cell cycle arrest.",B,high_candidate,curator_rejected,reject,derived_annotations_only,β-ionone synergizes with 5-Fluorouracil to inhibit gastric cancer progression through PAX6-mediated cell cycle arrest.
12908,42077,41504149,10.1002/advs.202515462,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Blood-Brain Barrier-Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42-Induced Oxidative Stress.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Blood-Brain Barrier-Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42-Induced Oxidative Stress.
12915,42084,41495803,10.1186/s13020-025-01285-w,toxicity,siRNA,PubMed abstract sentence 17,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Panduratin A from Boesenbergia rotunda suppresses hepatitis B virus by targeting HNF1α and synergizing with antiviral agents.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Panduratin A from Boesenbergia rotunda suppresses hepatitis B virus by targeting HNF1α and synergizing with antiviral agents.
12918,42087,41494786,10.1021/acsami.5c22573,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Biological Logic-Gated DNA Self-Assembly Strategy for Precision Tumor Imaging and Selective Activation of the cGAS-STING Pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Biological Logic-Gated DNA Self-Assembly Strategy for Precision Tumor Imaging and Selective Activation of the cGAS-STING Pathway.
12921,42090,41492227,10.1002/adhm.202505100,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Orchestrated Photothermal Nanoreactor Promoted Cuproptosis for Synergistic Cancer Therapy Through Glutathione Depletion and Gene Regulation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Orchestrated Photothermal Nanoreactor Promoted Cuproptosis for Synergistic Cancer Therapy Through Glutathione Depletion and Gene Regulation.
12924,42093,41490464,10.1055/a-2780-9033,toxicity,ASO,PubMed abstract sentence 3,risk;renal,"toxicity candidate; matched derived terms: risk, renal; source title: Perioperative Management of Patients Receiving Factor XI Inhibitors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Perioperative Management of Patients Receiving Factor XI Inhibitors.
12925,42094,41489768,10.1186/s11671-025-04411-7,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Harnessing albumin's natural tumor-targeting properties: nanoplatform strategies for triple-negative breast cancer therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Harnessing albumin's natural tumor-targeting properties: nanoplatform strategies for triple-negative breast cancer therapy.
12932,42101,41483378,10.1007/s13577-025-01344-2,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A p53-responsive microRNA-100 released from cardiomyoblasts serves as an early biomarker for acute coronary syndrome.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A p53-responsive microRNA-100 released from cardiomyoblasts serves as an early biomarker for acute coronary syndrome.
12934,42103,41482385,10.21873/invivo.14174,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: N-myristoyltransferase 1-mediated Src Myristoylation Promotes Non-receptor Tyrosine Kinase Pathways in Oral Squamous Cell Carcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,N-myristoyltransferase 1-mediated Src Myristoylation Promotes Non-receptor Tyrosine Kinase Pathways in Oral Squamous Cell Carcinoma.
12940,42109,41473775,10.1002/hsr2.71702,toxicity,siRNA,PubMed abstract sentence 13,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Rebalancing Hemostasis: Fitusiran as a First-in-Class RNAi Therapy in Hemophilia A and B.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rebalancing Hemostasis: Fitusiran as a First-in-Class RNAi Therapy in Hemophilia A and B.
12942,42111,41470012,10.1002/smll.202506474,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Molecular Materials as Fluorescent Nano Gene Silencers: Peptide Gold Cluster as Promising Cancer Theranostics.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Molecular Materials as Fluorescent Nano Gene Silencers: Peptide Gold Cluster as Promising Cancer Theranostics.
12949,42118,41461421,10.1016/j.pestbp.2025.106897,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cockroach cold preference: A behavioral strategy to defend fungal infection.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cockroach cold preference: A behavioral strategy to defend fungal infection.
12950,42119,41461321,10.1016/j.tox.2025.154388,toxicity,siRNA,PubMed abstract sentence 1,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Macrophage-epithelial cells crosstalk and the role of CCL2-CCR2 axis in single-walled carbon nanotubes-induced lung inflammation and fibrosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Macrophage-epithelial cells crosstalk and the role of CCL2-CCR2 axis in single-walled carbon nanotubes-induced lung inflammation and fibrosis.
12960,42129,41453580,10.1016/j.bbadis.2025.168148,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Repair of amyloid-β-induced plasma membrane damage via coordinated P21-activated kinase activation and Rab3a-directed vesicle fusion.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Repair of amyloid-β-induced plasma membrane damage via coordinated P21-activated kinase activation and Rab3a-directed vesicle fusion.
12968,42137,41422893,10.1016/j.labinv.2025.104273,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Roles for the Nerve Growth Factor-Farnesoid X Receptor-Retinol Dehydrogenase 16 Axis in Hepatocellular Carcinoma Prognosis and Chemosensitivity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Roles for the Nerve Growth Factor-Farnesoid X Receptor-Retinol Dehydrogenase 16 Axis in Hepatocellular Carcinoma Prognosis and Chemosensitivity.
12969,42138,41422812,10.1016/S2213-8587(25)00290-6,toxicity,siRNA,PubMed abstract sentence 3,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Zodasiran, an RNAi therapeutic targeting ANGPTL3, for treating patients with homozygous familial hypercholesterolaemia (GATEWAY): an open-label, randomised, phase 2 trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Zodasiran, an RNAi therapeutic targeting ANGPTL3, for treating patients with homozygous familial hypercholesterolaemia (GATEWAY): an open-label, randomised, phase 2 trial."
12971,42140,41422761,10.1016/j.jcis.2025.139717,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Promoting endogenous iron mediated ferroptosis for cancer therapy through gene interference and reactive oxygen species amplification.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Promoting endogenous iron mediated ferroptosis for cancer therapy through gene interference and reactive oxygen species amplification.
12972,42141,41418634,10.1016/j.phymed.2025.157649,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ginsenoside F3 alleviates T cell exhaustion via RIPOR2-mediated immunometabolic reprogramming to potentiate anti-PD-1 therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Ginsenoside F3 alleviates T cell exhaustion via RIPOR2-mediated immunometabolic reprogramming to potentiate anti-PD-1 therapy.
12978,42147,41380709,10.1016/S2665-9913(25)00226-7,toxicity,ASO,PubMed abstract sentence 6,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Transcutaneous auricular vagus nerve stimulation versus sham stimulation in patients with erosive hand osteoarthritis (ESTIVAL): a randomised, multicentre, double-blind, sham-controlled trial.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Transcutaneous auricular vagus nerve stimulation versus sham stimulation in patients with erosive hand osteoarthritis (ESTIVAL): a randomised, multicentre, double-blind, sham-controlled trial."
12980,42149,41380410,10.1016/j.phymed.2025.157648,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cucurbitacin I induces immunogenic cell death and synergistically potentiates cisplatin efficacy in epithelial ovarian cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cucurbitacin I induces immunogenic cell death and synergistically potentiates cisplatin efficacy in epithelial ovarian cancer.
12984,42153,41371037,10.1016/j.scitotenv.2025.181162,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Heat shock protein and Cathepsin B genes play important roles in cadmium stress response in whitefly Bemisia tabaci.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Heat shock protein and Cathepsin B genes play important roles in cadmium stress response in whitefly Bemisia tabaci.
12990,42159,41360995,10.1038/s41591-025-04119-2,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic;adverse;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, adverse, hepatotoxicity; source title: Intrathecal onasemnogene abeparvovec for treatment-experienced patients with spinal muscular atrophy: a phase 3b, open-label trial.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Intrathecal onasemnogene abeparvovec for treatment-experienced patients with spinal muscular atrophy: a phase 3b, open-label trial."
12991,42160,41360238,10.1016/j.ijbiomac.2025.149478,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cancer cell membrane-biomimetic and antioxidant-powered nanoplatform for overcoming multidrug resistance in triple-negative breast cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cancer cell membrane-biomimetic and antioxidant-powered nanoplatform for overcoming multidrug resistance in triple-negative breast cancer.
12994,42163,41352705,10.1016/j.ejphar.2025.178446,toxicity,siRNA,PubMed abstract sentence 3,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: Shifting tides from non-targeted chemotherapy to targeted therapies and small RNA-based bio drugs: A changing paradigm in cancer therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Shifting tides from non-targeted chemotherapy to targeted therapies and small RNA-based bio drugs: A changing paradigm in cancer therapy.
12997,42166,41351883,10.1093/jee/toaf269,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNAi-targeted silencing of OdfoCYP301A1 and OdfoGSTo1 increased the susceptibility of Odontotermes formosanus (Blattodea: Termitidae) to the nonsteroidal ecdysone agonist RH-5849.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RNAi-targeted silencing of OdfoCYP301A1 and OdfoGSTo1 increased the susceptibility of Odontotermes formosanus (Blattodea: Termitidae) to the nonsteroidal ecdysone agonist RH-5849.
12998,42167,41350085,10.1016/j.pestbp.2025.106831,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Overexpression of UDP-glycosyltransferase UGT344B29 and UGT344B30 involved in lambda-cyhalothrin resistance in Aphis spiraecola.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Overexpression of UDP-glycosyltransferase UGT344B29 and UGT344B30 involved in lambda-cyhalothrin resistance in Aphis spiraecola.
13003,42172,41349897,10.1016/j.arr.2025.102984,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Huntingtin protein in health and Huntington's disease: Molecular mechanisms, pathology and therapeutic strategies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Huntingtin protein in health and Huntington's disease: Molecular mechanisms, pathology and therapeutic strategies."
13006,42175,41344487,10.1016/j.jconrel.2025.114493,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Immunological conversion of triple-negative breast cancer by engineered extracellular vesicle-mediated pyroptosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Immunological conversion of triple-negative breast cancer by engineered extracellular vesicle-mediated pyroptosis.
13008,42177,41344272,10.1016/j.phymed.2025.157640,toxicity,siRNA,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Harmine inhibits non-small cell lung cancer growth by targeting phosphodiesterase4D and inducing ferroptosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Harmine inhibits non-small cell lung cancer growth by targeting phosphodiesterase4D and inducing ferroptosis.
13011,42180,41334811,10.1021/acs.biomac.5c01202,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hydrolytically Stable Cationic Bis-MPA Dendrimers as Efficient Transfectants for Glioblastoma Cells and Primary Astrocytes.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hydrolytically Stable Cationic Bis-MPA Dendrimers as Efficient Transfectants for Glioblastoma Cells and Primary Astrocytes.
13019,42188,41326080,10.1016/j.pestbp.2025.106791,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Genome-wide identification of ABC transporters and their contribution to triflumezopyrim susceptibility regulated by microRNAs in Laodelphax striatellus.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Genome-wide identification of ABC transporters and their contribution to triflumezopyrim susceptibility regulated by microRNAs in Laodelphax striatellus.
13024,42193,41317784,10.1016/j.fct.2025.115869,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: NCOA4-mediated ferritinophagy regulates AgNP-induced ferroptosis in lung cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,NCOA4-mediated ferritinophagy regulates AgNP-induced ferroptosis in lung cells.
13025,42194,41314588,10.1016/j.tox.2025.154357,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Notch1-dependent hippocampal apoptosis is associated with monocrotaline-induced anxiety-like behavior.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Notch1-dependent hippocampal apoptosis is associated with monocrotaline-induced anxiety-like behavior.
13033,42202,41270206,10.1002/advs.202515052,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Spatiotemporally Controlled Tumor Photodynamic/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Spatiotemporally Controlled Tumor Photodynamic/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem.
13043,42212,41212113,10.1161/CIRCGEN.125.005492,toxicity,ASO,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aberrant Splicing of DNM1L Impairs Cardiac Bioenergetics and Mitochondrial Dynamics in Myotonic Dystrophy Type I (DM1).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aberrant Splicing of DNM1L Impairs Cardiac Bioenergetics and Mitochondrial Dynamics in Myotonic Dystrophy Type I (DM1).
13055,42224,41168126,10.4070/kcj.2025.0035,toxicity,ASO,PubMed abstract sentence 5,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Long-term Outcomes of Standardized Strategy in Arterial Switch Operation: An 18-Year Review in a Single Center.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Long-term Outcomes of Standardized Strategy in Arterial Switch Operation: An 18-Year Review in a Single Center.
13057,42226,41161393,10.1016/j.freeradbiomed.2025.10.287,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cadmium induces ferroptosis in B cells via ATP6V0A1-upregulated lysosomal ferritinophagy: insights from murine transcriptomics and human cellular models.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cadmium induces ferroptosis in B cells via ATP6V0A1-upregulated lysosomal ferritinophagy: insights from murine transcriptomics and human cellular models.
13072,42241,41101550,10.1016/j.jep.2025.120751,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Huanglian-ejiao decoction ameliorates doxorubicin-induced cardiomyocyte apoptosis and autophagic flux dysregulation by up-regulating ubiquilin1.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Huanglian-ejiao decoction ameliorates doxorubicin-induced cardiomyocyte apoptosis and autophagic flux dysregulation by up-regulating ubiquilin1.
13073,42242,41097846,10.1002/adhm.202503721,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs.
13086,42255,40964941,10.1002/ps.70228,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of an eco-friendly RNAi yeast attractive targeted sugar bait that silences the shaker gene in spotted-wing drosophila, Drosophila suzukii.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Development of an eco-friendly RNAi yeast attractive targeted sugar bait that silences the shaker gene in spotted-wing drosophila, Drosophila suzukii."
13093,42262,40902370,10.1016/j.bioadv.2025.214477,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Acid-triggered nucleic acid release from gold nanoparticles via Schiff base linkages: In vitro validation of endosomal escape and gene silencing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Acid-triggered nucleic acid release from gold nanoparticles via Schiff base linkages: In vitro validation of endosomal escape and gene silencing.
13099,42268,40762902,10.1007/s13346-025-01920-x,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Genetically bio-engineered PD-L1 targeted exosomes for immunotherapy of resistant triple negative breast cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Genetically bio-engineered PD-L1 targeted exosomes for immunotherapy of resistant triple negative breast cancer.
13103,42272,40635224,10.2174/0118715273381241250620114740,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Insights into the Diagnosis, Treatment, and Management of Prion Diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Insights into the Diagnosis, Treatment, and Management of Prion Diseases."
13105,42274,40464188,10.2174/0115701638379447250526075127,toxicity,ASO,PubMed abstract sentence 1,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Pharmacological Insights on USFDA-approved Novel Drug Therapies in the Year 2023.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pharmacological Insights on USFDA-approved Novel Drug Therapies in the Year 2023.
13111,42280,41675514,10.3389/fonc.2025.1704436,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of colorectal cancer progression through conformation-specific targeting of ADAM10 metalloprotease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Inhibition of colorectal cancer progression through conformation-specific targeting of ADAM10 metalloprotease.
13125,42294,41586107,10.3389/fneur.2025.1582765,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ATH-1105 mitigates multiple pathologies in ALS models both alone and in combination with riluzole.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ATH-1105 mitigates multiple pathologies in ALS models both alone and in combination with riluzole.
13147,42316,41471099,10.3390/pharmaceutics17121584,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Intraluminal Vesicles as Transfection Intermediaries.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Intraluminal Vesicles as Transfection Intermediaries.
13150,42319,41465311,10.3390/ijms262411884,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Luteinizing Hormone-Releasing Hormone (LHRH)-Targeted Treatment in Ovarian Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Luteinizing Hormone-Releasing Hormone (LHRH)-Targeted Treatment in Ovarian Cancer.
13163,42332,41450180,10.1177/10600280251403512,toxicity,siRNA,PubMed abstract sentence 12,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Fitusiran: A Novel Antithrombin-Targeting Therapy for Hemophilia A and B, With or Without Inhibitors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Fitusiran: A Novel Antithrombin-Targeting Therapy for Hemophilia A and B, With or Without Inhibitors."
13179,42348,41409587,10.34172/bi.31475,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Allosteric ligand-driven smart nanoconjugates for mutation-selective EGFR targeting: A precision approach to overcoming tyrosine kinase inhibitor resistance.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Allosteric ligand-driven smart nanoconjugates for mutation-selective EGFR targeting: A precision approach to overcoming tyrosine kinase inhibitor resistance.
13184,42353,41394638,10.1101/2025.11.25.690484,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The molecular mechanism of uptake and cell-to-cell transmission of arginine-containing dipeptide repeat proteins.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The molecular mechanism of uptake and cell-to-cell transmission of arginine-containing dipeptide repeat proteins.
13185,42354,41393308,10.1016/j.omtn.2025.102697,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rational design and applications of piperazine and cyclohexane ionizable lipids for PKU and SSADH deficiency.
13186,42355,41392621,10.1021/acsami.5c15253,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Modular Design of Mesoporous Silica Nanoparticles Enables Bioimaging, Dual Chemotherapy, and Combinatorial Gene Silencing in Triple-Negative Breast Cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Modular Design of Mesoporous Silica Nanoparticles Enables Bioimaging, Dual Chemotherapy, and Combinatorial Gene Silencing in Triple-Negative Breast Cancer."
13188,42357,41392397,10.1002/cnr2.70425,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Toward Precision Medicine: Gene Therapy Applications in the Management of Uveal Melanoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Toward Precision Medicine: Gene Therapy Applications in the Management of Uveal Melanoma.
13208,42377,41351868,10.1021/acs.jafc.5c09429,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Fucoidan Alleviates Chemotherapy-Induced Peripheral Neuropathy via Activating the Gas6/MerTK Signaling Pathway to Reduce Neuroinflammation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Fucoidan Alleviates Chemotherapy-Induced Peripheral Neuropathy via Activating the Gas6/MerTK Signaling Pathway to Reduce Neuroinflammation.
13214,42383,41347876,10.1167/iovs.66.15.22,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sphingomyelin Synthase 2 Deletion Mitigates Oxidative Stress-Induced NF-κB Activation via Lipid Metabolic Reprogramming in Dry Eye Disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Sphingomyelin Synthase 2 Deletion Mitigates Oxidative Stress-Induced NF-κB Activation via Lipid Metabolic Reprogramming in Dry Eye Disease.
13217,42386,41339338,10.1038/s41419-025-08240-5,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Proteasome inhibition as a potential therapeutic target in thymic cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Proteasome inhibition as a potential therapeutic target in thymic cancer.
13222,42391,41326769,10.1038/s41746-025-02185-x,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia.
13226,42395,41317148,10.1080/13543784.2025.2598458,toxicity,siRNA,PubMed abstract sentence 7,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Assessing the clinical development of zerlasiran, a small-interfering RNA for elevated lipoprotein(a).",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Assessing the clinical development of zerlasiran, a small-interfering RNA for elevated lipoprotein(a)."
13229,42398,41312016,10.1016/j.omtn.2025.102748,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Multivalent aptamer engineered and functionalized NK cells for enhanced adoptive immunotherapy in CD30-positive malignant lymphoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Multivalent aptamer engineered and functionalized NK cells for enhanced adoptive immunotherapy in CD30-positive malignant lymphoma.
13239,42408,41304847,10.3390/ph18111600,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: VDAC1 Intervention Alleviates Bisphenol AF-Induced Succinate Metabolism Dysregulation and Inflammatory Responses.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,VDAC1 Intervention Alleviates Bisphenol AF-Induced Succinate Metabolism Dysregulation and Inflammatory Responses.
13242,42411,41303475,10.3390/ijms262210992,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cardiac Involvement in Myotonic Dystrophy Type 1: Mechanisms, Clinical Perspectives, and Emerging Therapeutic Strategies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Cardiac Involvement in Myotonic Dystrophy Type 1: Mechanisms, Clinical Perspectives, and Emerging Therapeutic Strategies."
13243,42412,41302918,10.3390/insects16111173,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transforming Tuta absoluta Management: A Synergistic Approach Integrating Sustainability, Biological Control, and Biotechnological Innovations.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Transforming Tuta absoluta Management: A Synergistic Approach Integrating Sustainability, Biological Control, and Biotechnological Innovations."
13246,42415,41301860,10.3390/biomedicines13112767,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic;hematological,"toxicity candidate; matched derived terms: toxicity, toxic, hematological; source title: Synergistic Inhibition of Triple-Negative Breast Cancer by Acetylsalicylic Acid and Recombinant Human APE1/Ref-1 in a Mouse Xenograft Model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Synergistic Inhibition of Triple-Negative Breast Cancer by Acetylsalicylic Acid and Recombinant Human APE1/Ref-1 in a Mouse Xenograft Model.
13247,42416,41301615,10.3390/antibiotics14111120,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of New Antimicrobial Peptides by Directional Selection.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of New Antimicrobial Peptides by Directional Selection.
13256,42425,41290746,10.1038/s41467-025-66630-x,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Silencing PCSK9 reshapes the spatiotemporal activation of STING for safe and effective cancer immunotherapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Silencing PCSK9 reshapes the spatiotemporal activation of STING for safe and effective cancer immunotherapy.
13258,42427,41290726,10.1038/s41538-025-00574-w,toxicity,siRNA,PubMed abstract sentence 1,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: AMP-activated protein kinase-Caspase 6 axis regulation alleviates the combined apoptotic damage caused by deoxynivalenol and fumonisin B1 in mammary glands.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,AMP-activated protein kinase-Caspase 6 axis regulation alleviates the combined apoptotic damage caused by deoxynivalenol and fumonisin B1 in mammary glands.
13273,42442,41277253,10.1021/acs.analchem.5c04366,toxicity,ASO/siRNA,PubMed abstract sentence 1,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Allosteric Regulation of Spherical Nucleic Acid for Facile Discrimination of Patients with Different Heart Failure Severity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Allosteric Regulation of Spherical Nucleic Acid for Facile Discrimination of Patients with Different Heart Failure Severity.
13275,42444,41276866,10.1186/s13287-025-04781-w,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cutting-edge treatments in amyotrophic lateral sclerosis: the role of molecular pathogenesis in targeted therapies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cutting-edge treatments in amyotrophic lateral sclerosis: the role of molecular pathogenesis in targeted therapies.
13279,42448,41262162,10.1002/ece3.72527,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bulk Segregant Analysis Reveals Genomic Regions Associated With Imidacloprid Resistance in the Colorado Potato Beetle.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bulk Segregant Analysis Reveals Genomic Regions Associated With Imidacloprid Resistance in the Colorado Potato Beetle.
13282,42451,41259544,10.1021/acs.jafc.5c09357,toxicity,siRNA,PubMed abstract sentence 1,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: MdWRKY17 Enhances Cadmium Tolerance in Malus domestica via the Transcriptional Activation of the Gene MdHIPP1 Encoding Heavy-Metal-Associated Isoprenylated Plant Protein.",B,high_candidate,curator_rejected,reject,derived_annotations_only,MdWRKY17 Enhances Cadmium Tolerance in Malus domestica via the Transcriptional Activation of the Gene MdHIPP1 Encoding Heavy-Metal-Associated Isoprenylated Plant Protein.
13285,42454,41256290,10.1093/narmme/ugaf023,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Characterization of DMPK and MBNL1 expression in cell models of myotonic dystrophy: a platform for drug screening.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Characterization of DMPK and MBNL1 expression in cell models of myotonic dystrophy: a platform for drug screening.
13291,42460,41251525,10.1167/iovs.66.14.44,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Scutellarin Protects Retinal Ganglion Cells in Glaucoma by Targeting the Hsp90aa1-MAPK Pathway to Inhibit Apoptosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Scutellarin Protects Retinal Ganglion Cells in Glaucoma by Targeting the Hsp90aa1-MAPK Pathway to Inhibit Apoptosis.
13295,42464,41249096,10.1021/acsinfecdis.5c00721,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: In Vivo MicroRNA-Based Inhibition of Experimental Cestode Infection.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In Vivo MicroRNA-Based Inhibition of Experimental Cestode Infection.
13299,42468,41236780,10.1021/acsabm.5c01852,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Mineral Oil Encapsulation Enhances dsRNA-Based Acaricidal Activity against Amphitetranychus viennensis .",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mineral Oil Encapsulation Enhances dsRNA-Based Acaricidal Activity against Amphitetranychus viennensis.
13305,42474,41233563,10.1038/s41598-025-23587-7,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Overexpressed MET drives aggressive thyroid cancer phenotypes and serves as a precision therapeutic target.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Overexpressed MET drives aggressive thyroid cancer phenotypes and serves as a precision therapeutic target.
13308,42477,41230834,10.1111/jcmm.70946,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Uncovering the Critical Role of Cuproptosis in Wilson Disease: Insights Into Potential Therapeutic Targets.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Uncovering the Critical Role of Cuproptosis in Wilson Disease: Insights Into Potential Therapeutic Targets.
13315,42484,41226635,10.3390/ijms262110582,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Anti-Angiogenic RNAi-Based Treatment of Endometriosis in a Rat Model Using CXCR4-Targeted Peptide Nanoparticles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Anti-Angiogenic RNAi-Based Treatment of Endometriosis in a Rat Model Using CXCR4-Targeted Peptide Nanoparticles.
13338,42507,41199672,10.1002/chem.202502995,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Development of Synthetic Routes to 2'-O,4'-C-Spirocyclopentylene-Bridged Nucleic Acids: Thymidine, Guanosine, and Adenosine.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Development of Synthetic Routes to 2'-O,4'-C-Spirocyclopentylene-Bridged Nucleic Acids: Thymidine, Guanosine, and Adenosine."
13340,42509,41197701,10.1016/j.ijbiomac.2025.148785,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Rhamno-oligosaccharide-based glycoconjugates as promising vaccine candidates against Group A Streptococcus.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Rhamno-oligosaccharide-based glycoconjugates as promising vaccine candidates against Group A Streptococcus.
13341,42510,41197639,10.1002/wnan.70040,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Harnessing the Power of D-Alpha-Tocopheryl Polyethylene Glycol Succinate-Based Nanoparticles for Targeted Breast Cancer Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Harnessing the Power of D-Alpha-Tocopheryl Polyethylene Glycol Succinate-Based Nanoparticles for Targeted Breast Cancer Therapy.
13344,42513,41196659,10.1002/cpz1.70249,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Programmable Aptamer-Drug Conjugates: Expanding Automated and Modular Platforms for Targeted Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Programmable Aptamer-Drug Conjugates: Expanding Automated and Modular Platforms for Targeted Therapeutics.
13348,42517,41194772,10.1021/acschembio.5c00614,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Circular Aptamer-ASO Chimera for Activating DLX5-Regulated Osteogenesis through Targeted Inhibition of STAT5A Expression.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Circular Aptamer-ASO Chimera for Activating DLX5-Regulated Osteogenesis through Targeted Inhibition of STAT5A Expression.
13352,42521,41189671,10.1016/j.ijpx.2025.100419,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advancing cancer radiotherapy: Harnessing radiosensitizers and nanotechnology for enhanced tumor control.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advancing cancer radiotherapy: Harnessing radiosensitizers and nanotechnology for enhanced tumor control.
13360,42529,41172144,10.1093/mutage/geaf025,toxicity,ASO,PubMed abstract sentence 2,toxic;dna damage,"toxicity candidate; matched derived terms: toxic, dna damage; source title: The use of DNA repair inhibitors and the comet assay-an overview.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The use of DNA repair inhibitors and the comet assay-an overview.
13362,42531,41168832,10.1186/s12967-025-07252-1,toxicity,ASO,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting lncRNA MALAT1 attenuates lenalidomide resistance via CD38 epigenetic modulation, oxidative stress-mediated cell death, and remodeling of the pro-tumor microenvironment in multiple myeloma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Targeting lncRNA MALAT1 attenuates lenalidomide resistance via CD38 epigenetic modulation, oxidative stress-mediated cell death, and remodeling of the pro-tumor microenvironment in multiple myeloma."
13368,42537,41163839,10.1039/d5ra04610f,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: An injectable hydrogel containing N -acetylglycine for the treatment of Gaucher disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An injectable hydrogel containing N-acetylglycine for the treatment of Gaucher disease.
13384,42553,41154195,10.3390/brainsci15101101,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Therapeutic Advances in Targeting the Amyloid-β Pathway for Alzheimer's Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Therapeutic Advances in Targeting the Amyloid-β Pathway for Alzheimer's Disease.
13386,42555,41151066,10.1042/BSR20253356,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transgenic mouse models of sodium and potassium channelopathies in epilepsy: insights into disease mechanisms and therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transgenic mouse models of sodium and potassium channelopathies in epilepsy: insights into disease mechanisms and therapeutics.
13387,42556,41149852,10.3390/jpm15100490,toxicity,ASO,PubMed abstract sentence 7,risk;renal,"toxicity candidate; matched derived terms: risk, renal; source title: Next-Generation Anticoagulants: Precision Strategies for Patient-Centered Thromboprophylaxis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Next-Generation Anticoagulants: Precision Strategies for Patient-Centered Thromboprophylaxis.
13399,42568,41124733,10.1016/j.jhazmat.2025.140193,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoplastic-induced NAT10/ac4C axis drives both oxidative stress and chemoresistance.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Nanoplastic-induced NAT10/ac4C axis drives both oxidative stress and chemoresistance.
13403,42572,41115949,10.1038/s41531-025-01142-5,toxicity,ASO,PubMed abstract sentence 2,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model.
13407,42576,41112250,10.3389/fimmu.2025.1657040,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gene expression silencing therapy in tumors, focus on gastrointestinal and genitourinary tumors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Gene expression silencing therapy in tumors, focus on gastrointestinal and genitourinary tumors."
13409,42578,41110302,10.1016/j.ecoenv.2025.119239,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nitrite and microcystins co-exposure triggers PINK1-mediated mitophagy in spermatogonia.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nitrite and microcystins co-exposure triggers PINK1-mediated mitophagy in spermatogonia.
13410,42579,41109439,10.1016/j.actbio.2025.10.030,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Design and evaluation of cationic bottlebrush polymers for advanced messenger RNA therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Design and evaluation of cationic bottlebrush polymers for advanced messenger RNA therapeutics.
13427,42596,41088826,10.1021/jacs.5c15945,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In Situ PROTAC Synthesis Enabled by Pathologically Activated Bioorthogonal Catalysis for Precision Cancer Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In Situ PROTAC Synthesis Enabled by Pathologically Activated Bioorthogonal Catalysis for Precision Cancer Therapy.
13432,42601,41086675,10.1016/j.phymed.2025.157283,toxicity,siRNA,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ailanthone targets mitophagy-loaded SIRT4 to facilitate the deacetylation of HIF1α, triggering oxidative stress for gastric carcinoma treatment.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Ailanthone targets mitophagy-loaded SIRT4 to facilitate the deacetylation of HIF1α, triggering oxidative stress for gastric carcinoma treatment."
13434,42603,41084272,10.1111/1744-7917.70185,offtarget,siRNA,PubMed abstract sentence 8,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Integrated transcriptomic and RNAi approaches uncover a key role for ApApoD1 in the desiccation tolerance of Acyrthosiphon pisum.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Integrated transcriptomic and RNAi approaches uncover a key role for ApApoD1 in the desiccation tolerance of Acyrthosiphon pisum.
13442,42611,41080511,10.1007/s12298-025-01564-8,toxicity,siRNA,PubMed abstract sentence 7,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Harnessing double-stranded RNA (dsRNA): a sustainable approach to pest management.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Harnessing double-stranded RNA (dsRNA): a sustainable approach to pest management.
13443,42612,41080447,10.21769/BioProtoc.5464,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Image-Based Profiling in Live Cells Using Live Cell Painting.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Image-Based Profiling in Live Cells Using Live Cell Painting.
13450,42619,41075454,10.1016/j.ejca.2025.116040,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Specific targeting of the pseudogene RPSAP52 reduces ovarian tumor growth in patient-derived orthoxenograft models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Specific targeting of the pseudogene RPSAP52 reduces ovarian tumor growth in patient-derived orthoxenograft models.
13451,42620,41075357,10.1016/j.retram.2025.103545,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Revolutionizing pediatric gene and cell therapy: The hope for lipid-based nanoparticles in blood disorders.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Revolutionizing pediatric gene and cell therapy: The hope for lipid-based nanoparticles in blood disorders.
13458,42627,41067564,10.1016/j.antiviral.2025.106288,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Small molecule HBV RNA destabilizing drugs: Drugs of the future or compounds from the past?",B,high_candidate,curator_rejected,reject,derived_annotations_only,Small molecule HBV RNA destabilizing drugs: Drugs of the future or compounds from the past?
13461,42630,41058938,10.2147/IJN.S542725,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting Multiple Pathophysiological Axes in COPD: Nanomaterial Advances.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting Multiple Pathophysiological Axes in COPD: Nanomaterial Advances.
13465,42634,41056858,10.1016/j.phymed.2025.157302,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Xin-Ji-Er-Kang modulates NRF2 to inhibit ferroptosis and attenuate doxorubicin-induced myocardial injury.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Xin-Ji-Er-Kang modulates NRF2 to inhibit ferroptosis and attenuate doxorubicin-induced myocardial injury.
13467,42636,41055316,10.1177/15230864251380269,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Circular RNA-Directed Therapeutic Strategy for Cold-Induced Diabetic Macrovascular Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Circular RNA-Directed Therapeutic Strategy for Cold-Induced Diabetic Macrovascular Disease.
13474,42643,41049425,10.7150/ijms.116656,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting LC3B/MCL-1 expression by Protodioscin induces autophagy and apoptosis in human glioblastoma cells in vitro and in vivo .",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting LC3B/MCL-1 expression by Protodioscin induces autophagy and apoptosis in human glioblastoma cells in vitro and in vivo.
13479,42648,41046827,10.1016/j.intimp.2025.115633,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting TBXAS1: a novel target of daidzein in alleviating APAP-induced hepatic injury.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting TBXAS1: a novel target of daidzein in alleviating APAP-induced hepatic injury.
13485,42654,41038334,10.1016/j.dci.2025.105482,offtarget,siRNA,PubMed abstract sentence 4,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: A review of host and pathogen gene targets for RNAi therapeutics in shrimp disease mitigation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A review of host and pathogen gene targets for RNAi therapeutics in shrimp disease mitigation.
13490,42659,41034579,10.1038/s41586-025-09557-z,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Panoptes system uses decoy cyclic nucleotides to defend against phage.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Panoptes system uses decoy cyclic nucleotides to defend against phage.
13510,42679,41012445,10.3390/pharmaceutics17091106,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Aptamer-Nanoconjugates as Potential Theranostics in Major Neuro-Oncological and Neurodegenerative Disorders.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamer-Nanoconjugates as Potential Theranostics in Major Neuro-Oncological and Neurodegenerative Disorders.
13523,42692,41004055,10.1007/978-3-031-97055-9_5,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Therapeutic Trajectories in Human Prion Diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Therapeutic Trajectories in Human Prion Diseases.
13539,42708,40981348,10.3390/jox15050137,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Silica Nanoparticles Induced Epithelial-Mesenchymal Transition in BEAS-2B Cells via ER Stress and SIRT1/HSF1/HSPs Signaling Pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silica Nanoparticles Induced Epithelial-Mesenchymal Transition in BEAS-2B Cells via ER Stress and SIRT1/HSF1/HSPs Signaling Pathway.
13549,42718,40970667,10.1167/iovs.66.12.46,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exon Skipping Therapy Restores Ciliary Function in USH2A-Related Retinal Degeneration.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Exon Skipping Therapy Restores Ciliary Function in USH2A-Related Retinal Degeneration.
13553,42722,40968429,10.2174/011871529X390148250908045359,toxicity,siRNA,PubMed abstract sentence 4,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Lepodisiran: Effects on Lipoprotein(a) and Cardiovascular Outcomes in Adults with Elevated Lp(a).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lepodisiran: Effects on Lipoprotein(a) and Cardiovascular Outcomes in Adults with Elevated Lp(a).
13565,42734,40949934,10.4330/wjc.v17.i8.109657,toxicity,ASO/siRNA,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Lepodisiran: From genetic targeting to cardiovascular promise: A detailed narrative review of the literature.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lepodisiran: From genetic targeting to cardiovascular promise: A detailed narrative review of the literature.
13582,42751,40936959,10.1039/d5ra05615b,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Golden eyes on pollutants: colorimetric detection of emerging contaminants with AuNPs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Golden eyes on pollutants: colorimetric detection of emerging contaminants with AuNPs.
13584,42753,40934975,10.1016/j.arr.2025.102895,toxicity,ASO,PubMed abstract sentence 5,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Use of factor XI/XIa inhibitors in patients with atrial fibrillation: Current progress and future prospects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Use of factor XI/XIa inhibitors in patients with atrial fibrillation: Current progress and future prospects.
13598,42767,40915839,10.1016/j.pestbp.2025.106583,toxicity,siRNA,PubMed abstract sentence 11,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: RNAi bioassays targeting bursicon reveal potential targets for pest control of Henosepilachna vigintioctopunctata.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi bioassays targeting bursicon reveal potential targets for pest control of Henosepilachna vigintioctopunctata.
13606,42775,40912099,10.1016/j.ecoenv.2025.118998,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: The role of REST in regulating the BDNF/TrkB signalling pathway in nano-alumina induced cognitive dysfunction in zebrafish.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The role of REST in regulating the BDNF/TrkB signalling pathway in nano-alumina induced cognitive dysfunction in zebrafish.
13624,42793,40885724,10.1038/s41467-025-63415-0,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA.
13634,42803,40879257,10.1002/ps.70171,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: New insights into the insecticidal mode of action of diatomite nanoparticles.",B,high_candidate,curator_rejected,reject,derived_annotations_only,New insights into the insecticidal mode of action of diatomite nanoparticles.
13640,42809,40876559,10.1016/j.autrev.2025.103918,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hedgehog signaling pathway: A research review on a new therapeutic target for rheumatoid arthritis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hedgehog signaling pathway: A research review on a new therapeutic target for rheumatoid arthritis.
13642,42811,40874819,10.1093/bib/bbaf443,offtarget,siRNA,PubMed abstract sentence 2,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: BBANsh: a deep learning architecture based on BERT and bilinear attention networks to identify potent shRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,BBANsh: a deep learning architecture based on BERT and bilinear attention networks to identify potent shRNA.
13650,42819,40869421,10.3390/ijms26168101,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Retinoic Acid-Induced Transglutaminase 2 Expression Reduces Sensitivity to Cisplatin in the Hormone-Positive MCF-7 Breast Cancer Cell Model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Retinoic Acid-Induced Transglutaminase 2 Expression Reduces Sensitivity to Cisplatin in the Hormone-Positive MCF-7 Breast Cancer Cell Model.
13652,42821,40867903,10.3390/antiox14081007,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cyclodextrin-Based Nanotransporters as a Versatile Tool to Manage Oxidative Stress-Induced Lung Diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cyclodextrin-Based Nanotransporters as a Versatile Tool to Manage Oxidative Stress-Induced Lung Diseases.
13656,42825,40860155,10.7150/thno.114534,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PTEN restoration and CXCR2 depletion synergistically enhance the effect of enzalutamide and inhibit bone metastatic CRPC.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PTEN restoration and CXCR2 depletion synergistically enhance the effect of enzalutamide and inhibit bone metastatic CRPC.
13666,42835,40848064,10.1007/s00262-025-04148-3,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermia.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermia."
13669,42838,40846040,10.1016/j.jep.2025.120449,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: YinxingGujin decoction suppresses lung adenocarcinoma metastasis by modulating the TGF-β/STAT3/PD-L1 Axis: Network pharmacology and experimental validation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,YinxingGujin decoction suppresses lung adenocarcinoma metastasis by modulating the TGF-β/STAT3/PD-L1 Axis: Network pharmacology and experimental validation.
13670,42839,40845764,10.1016/j.jri.2025.104633,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: SQSTM1/p62 drives radiosensitivity in cervical cancer via autophagy-independent mechanisms.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,SQSTM1/p62 drives radiosensitivity in cervical cancer via autophagy-independent mechanisms.
13673,42842,40843899,10.1002/bit.70043,toxicity,ASO/siRNA,PubMed abstract sentence 1,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Endogenous Retrovirus-Like Particle-Deficient CHO Cells Can be Generated by CRISPR or shRNA and Enriched Based on Cell-Surface Expression of Retroviral Envelope Protein.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Endogenous Retrovirus-Like Particle-Deficient CHO Cells Can be Generated by CRISPR or shRNA and Enriched Based on Cell-Surface Expression of Retroviral Envelope Protein.
13674,42843,40843354,10.20517/cdr.2025.119,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: IRE1α modulates M1 oncolytic virus sensitivity via ER stress regulation in bladder cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,IRE1α modulates M1 oncolytic virus sensitivity via ER stress regulation in bladder cancer.
13687,42856,40829058,10.1002/cbdv.202500289,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aptamers: A Promising Tool to Combat Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamers: A Promising Tool to Combat Cancer.
13691,42860,40824336,10.1007/s41061-025-00516-w,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Recent Advances in Functionally Engineered Aptamers: Strategies and Applications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Recent Advances in Functionally Engineered Aptamers: Strategies and Applications.
13697,42866,40816462,10.1016/j.fct.2025.115699,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The effect and mechanism of NCOA4-mediated ferritinophagy in aluminum-induced ferroptosis of PC12 cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The effect and mechanism of NCOA4-mediated ferritinophagy in aluminum-induced ferroptosis of PC12 cells.
13715,42884,40787447,10.3389/fimmu.2025.1610717,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Programmed cell death signatures-driven microglial transformation in Alzheimer's disease: single-cell transcriptomics and functional validation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Programmed cell death signatures-driven microglial transformation in Alzheimer's disease: single-cell transcriptomics and functional validation.
13722,42891,40779824,10.1016/j.phymed.2025.157124,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Rational combination of homoharringtonine to selectively target FLT3-ITD acute myeloid leukemia through synthetic lethality.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rational combination of homoharringtonine to selectively target FLT3-ITD acute myeloid leukemia through synthetic lethality.
13731,42900,40769675,10.1016/j.jacc.2025.04.055,toxicity,ASO/siRNA,PubMed abstract sentence 12,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Impact of Vutrisiran on Cardiac Biomarkers in Patients With Transthyretin Amyloidosis With Cardiomyopathy From HELIOS-B.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Impact of Vutrisiran on Cardiac Biomarkers in Patients With Transthyretin Amyloidosis With Cardiomyopathy From HELIOS-B.
13734,42903,40755363,10.1002/advs.202507975,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Decoy Extracellular Vesicles Overcome Triple-Negative Breast Cancer Heterogeneity via Membrane-Cytoplasm-Mitochondria Cascade Targeting.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Decoy Extracellular Vesicles Overcome Triple-Negative Breast Cancer Heterogeneity via Membrane-Cytoplasm-Mitochondria Cascade Targeting.
13738,42907,40752498,10.1016/S2213-2600(25)00206-1,toxicity,ASO,PubMed abstract sentence 5,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Maximising opportunity for therapeutic success: sequential participation in cystic fibrosis nucleic acid-based therapy trials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Maximising opportunity for therapeutic success: sequential participation in cystic fibrosis nucleic acid-based therapy trials.
13740,42909,40751315,10.1016/j.ymthe.2025.07.039,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The chimeric aptamer axl-miR-214sponge inhibits breast cancer and melanoma dissemination.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The chimeric aptamer axl-miR-214sponge inhibits breast cancer and melanoma dissemination.
13743,42912,40745699,10.1021/jacs.5c08345,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Overlooked Stereoisomers of the Ionizable Lipid ALC315.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Overlooked Stereoisomers of the Ionizable Lipid ALC315.
13752,42921,40728866,10.1021/acs.analchem.5c03832,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Mitochondria-Targeted Polymeric Liposomes for Pre-miRNA Imaging and Gene Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mitochondria-Targeted Polymeric Liposomes for Pre-miRNA Imaging and Gene Therapy.
13757,42926,40720029,10.1007/978-1-0716-4730-1_22,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In Vivo Evaluation of Multiple Exon Skipping with Peptide-PMOs in Cardiac and Skeletal Muscles in Dystrophic Dogs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In Vivo Evaluation of Multiple Exon Skipping with Peptide-PMOs in Cardiac and Skeletal Muscles in Dystrophic Dogs.
13758,42927,40719980,10.1007/s12032-025-02725-1,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advancements in lung cancer: molecular insights, innovative therapies, and future prospects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Advancements in lung cancer: molecular insights, innovative therapies, and future prospects."
13760,42929,40717121,10.1186/s12915-025-02342-4,offtarget,siRNA,PubMed abstract sentence 5,transcriptome;hybridization,"offtarget candidate; matched derived terms: transcriptome, hybridization; source title: An ovarian insulin-like peptide specifically regulates energy allocation and oocyte development in nutrition-restricted cockroaches.",B,high_candidate,curator_rejected,reject,derived_annotations_only,An ovarian insulin-like peptide specifically regulates energy allocation and oocyte development in nutrition-restricted cockroaches.
13762,42931,40712497,10.1016/j.heares.2025.109372,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Prevention of aminoglycoside-induced outer hair cell loss by silencing CaMKKβ in an acute mouse model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Prevention of aminoglycoside-induced outer hair cell loss by silencing CaMKKβ in an acute mouse model.
13763,42932,40712413,10.1016/j.drup.2025.101277,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineering nanoplatforms of bacterial outer membrane vesicles to overcome cancer therapy resistance.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineering nanoplatforms of bacterial outer membrane vesicles to overcome cancer therapy resistance.
13764,42933,40710983,10.3390/toxics13070538,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: NOX2/NLRP3-Inflammasome-Dependent Microglia Activation Promotes As(III)-Induced Learning and Memory Impairments in Developmental Rats.",B,high_candidate,curator_rejected,reject,derived_annotations_only,NOX2/NLRP3-Inflammasome-Dependent Microglia Activation Promotes As(III)-Induced Learning and Memory Impairments in Developmental Rats.
13785,42954,40694678,10.1021/acs.jafc.4c11912,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Key Flavor Substance in Zanthoxylum Preventing Alzheimer's Disease through Insulin Signaling.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The Key Flavor Substance in Zanthoxylum Preventing Alzheimer's Disease through Insulin Signaling.
13789,42958,40685728,10.2174/0118715206377167250709062942,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Innovative Nanocarriers: Magnetosomes in the Fight against Cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Innovative Nanocarriers: Magnetosomes in the Fight against Cancer.
13790,42959,40685636,10.1021/acs.jmedchem.5c00492,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Novel Aptamer-Drug Conjugate for Targeted Therapy in Triple-Negative Breast Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Novel Aptamer-Drug Conjugate for Targeted Therapy in Triple-Negative Breast Cancer.
13793,42962,40682728,10.1007/s40618-025-02656-8,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: 1α,25(OH) 2 D 3 alleviates perfluorooctane sulfonic acid-induced oxidative injury through the Nrf2-ARE pathway via VDR in Sertoli cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"1α,25(OH)(2)D(3) alleviates perfluorooctane sulfonic acid-induced oxidative injury through the Nrf2-ARE pathway via VDR in Sertoli cells."
13795,42964,40680668,10.1016/j.bbrc.2025.152361,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Anti-nucleolin aptamer-guided anticancer activity of AS1411-Chalcone conjugate in breast cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Anti-nucleolin aptamer-guided anticancer activity of AS1411-Chalcone conjugate in breast cancer.
13806,42975,40671119,10.1186/s13062-025-00664-5,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Extracellular vesicle-enriched secretome of adipose-derived stem cells upregulates clusterin to alleviate doxorubicin-induced apoptosis in cardiomyocytes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Extracellular vesicle-enriched secretome of adipose-derived stem cells upregulates clusterin to alleviate doxorubicin-induced apoptosis in cardiomyocytes.
13814,42983,40663327,10.1007/978-1-0716-4578-9_9,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Parallel and Automated PNA Synthesis in μSPOT Format.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Parallel and Automated PNA Synthesis in μSPOT Format.
13822,42991,40654672,10.1101/2025.05.01.651783,toxicity,ASO,PubMed abstract sentence 12,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Endothelial AGO1 Drives Vascular Inflammation and Atherosclerosis via a Non-Canonical Nuclear Mechanism.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Endothelial AGO1 Drives Vascular Inflammation and Atherosclerosis via a Non-Canonical Nuclear Mechanism.
13825,42994,40648030,10.3390/plants14132021,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Molecular Mechanisms of Plant Stress Memory: Roles of Non-Coding RNAs and Alternative Splicing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Molecular Mechanisms of Plant Stress Memory: Roles of Non-Coding RNAs and Alternative Splicing.
13827,42996,40645721,10.1016/j.jaccas.2025.103897,toxicity,ASO/siRNA,PubMed abstract sentence 2,safety;renal,"toxicity candidate; matched derived terms: safety, renal; source title: Treatment With Inclisiran During Peritoneal Dialysis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Treatment With Inclisiran During Peritoneal Dialysis.
13829,42998,40643531,10.3390/cells14131010,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ciprofloxacin Exerts Anti-Tumor Effects In Vivo Through cGAS-STING Activation and Modulates Tumor Microenvironment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ciprofloxacin Exerts Anti-Tumor Effects In Vivo Through cGAS-STING Activation and Modulates Tumor Microenvironment.
13832,43001,40641024,10.2174/0115680266373170250624095758,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exosome-Mediated Strategies for Melanoma Eradication: A Comprehensive Review.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exosome-Mediated Strategies for Melanoma Eradication: A Comprehensive Review.
13833,43002,40641021,10.2174/0122117385373434250705125526,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanocarriers in Atopic Dermatitis Therapy: A Comprehensive Exploration.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Nanocarriers in Atopic Dermatitis Therapy: A Comprehensive Exploration.
13834,43003,40640528,10.1007/s40263-025-01204-5,toxicity,ASO,PubMed abstract sentence 6,risk;tolerability,"toxicity candidate; matched derived terms: risk, tolerability; source title: Tofersen: A Review in Amyotrophic Lateral Sclerosis Associated with SOD1 Mutations.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tofersen: A Review in Amyotrophic Lateral Sclerosis Associated with SOD1 Mutations.
13846,43015,40625690,10.1093/toxres/tfaf084,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hsp90 inhibition attenuates the 1, 2-Dichloroethane-induced cognitive impairment by blocking NLRP3 inflammasome activation in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Hsp90 inhibition attenuates the 1, 2-Dichloroethane-induced cognitive impairment by blocking NLRP3 inflammasome activation in mice."
13850,43019,40624770,10.1111/pcmr.70036,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: YAP Upregulation Contributes to Acquired Resistance to BET Inhibitors in Uveal Melanoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,YAP Upregulation Contributes to Acquired Resistance to BET Inhibitors in Uveal Melanoma.
13851,43020,40623538,10.1016/j.freeradbiomed.2025.07.007,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aerobic exercise ameliorates skeletal muscle atrophy in atic knockout zebrafish through the oxidative phosphorylation pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aerobic exercise ameliorates skeletal muscle atrophy in atic knockout zebrafish through the oxidative phosphorylation pathway.
13863,43032,40608957,10.1093/brain/awaf249,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exon skipping peptide-conjugated morpholinos downregulate dynamin 2 to rescue centronuclear myopathy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Exon skipping peptide-conjugated morpholinos downregulate dynamin 2 to rescue centronuclear myopathy.
13864,43033,40608189,10.1007/s12017-025-08870-0,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Dysbiosis and Neurodegeneration in ALS: Unraveling the Gut-Brain Axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dysbiosis and Neurodegeneration in ALS: Unraveling the Gut-Brain Axis.
13866,43035,40607388,10.3389/fimmu.2025.1537876,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.
13878,43047,40590508,10.1002/jobm.70070,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Emerging Therapeutic Strategies to Combat Antimicrobial Resistance in the Post-Antibiotic Era.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Emerging Therapeutic Strategies to Combat Antimicrobial Resistance in the Post-Antibiotic Era.
13881,43050,40588821,10.1002/bcp.70152,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ABCC4 polymorphism indirectly reduces systemic exposure to a capecitabine metabolite 5'-deoxy-5-fluorouridine in Japanese subjects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ABCC4 polymorphism indirectly reduces systemic exposure to a capecitabine metabolite 5'-deoxy-5-fluorouridine in Japanese subjects.
13889,43058,40575763,10.1093/rb/rbaf043,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Y-shaped DNA as a dynamic self-assembly nanomaterial for phenotype-specific regulation of stem cell differentiation on the gene level.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Y-shaped DNA as a dynamic self-assembly nanomaterial for phenotype-specific regulation of stem cell differentiation on the gene level.
13890,43059,40574101,10.3390/pharmaceutics17060789,toxicity,ASO,PubMed abstract sentence 13,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Intravenous Administration of sRNA Nanoparticles for Treatment of Osteoporosis in Mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Intravenous Administration of sRNA Nanoparticles for Treatment of Osteoporosis in Mice.
13899,43068,40562864,10.1038/s41380-025-03089-8,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The mechanisms underlying TDP-43-associated neurodegeneration in Alzheimer's disease and related dementias.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The mechanisms underlying TDP-43-associated neurodegeneration in Alzheimer's disease and related dementias.
13911,43080,40553247,10.1007/s43440-025-00757-y,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes.
13913,43082,40551403,10.1080/13880209.2025.2514021,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Mechanisms of action and therapeutic potential of PCSK9-regulating drugs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mechanisms of action and therapeutic potential of PCSK9-regulating drugs.
13918,43087,40544907,10.1016/j.cbi.2025.111611,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Regulation of ferroptosis ameliorates silica nanoparticle-induced lung injury by inhibiting NCOA4-mediated ferritinophagy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Regulation of ferroptosis ameliorates silica nanoparticle-induced lung injury by inhibiting NCOA4-mediated ferritinophagy.
13928,43097,40538534,10.3389/fphar.2025.1544666,toxicity,siRNA,PubMed abstract sentence 18,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Anticancer activity of RM-3-22: a TAZQ-based hydroxamic acid derivative targeting NSCLC in vitro and in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Anticancer activity of RM-3-22: a TAZQ-based hydroxamic acid derivative targeting NSCLC in vitro and in vivo.
13933,43102,40532648,10.1016/j.plaphy.2025.110158,offtarget,ASO,PubMed abstract sentence 9,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: The CsUGT87A1 gene enhances drought stress tolerance in tea plants by modulating IAA homeostasis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The CsUGT87A1 gene enhances drought stress tolerance in tea plants by modulating IAA homeostasis.
13936,43105,40531599,10.1002/adhm.202501009,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Enhanced Xanthium-Inspired ZnO for Precision Antibacterial Therapy and Regeneration of Infected Wounds.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhanced Xanthium-Inspired ZnO for Precision Antibacterial Therapy and Regeneration of Infected Wounds.
13940,43109,40528841,10.1016/j.mtbio.2025.101917,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Thermosensitive hydrogel composite with si-Cx43 nanoparticles and anti-VEGF agent for synergistic treatment of diabetic retinopathy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Thermosensitive hydrogel composite with si-Cx43 nanoparticles and anti-VEGF agent for synergistic treatment of diabetic retinopathy.
13947,43116,40521219,10.1007/s13205-025-04378-3,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Breaking barriers: exploring blood-brain barrier crossing mechanisms with nanomedicine for effective glioma treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Breaking barriers: exploring blood-brain barrier crossing mechanisms with nanomedicine for effective glioma treatment.
13959,43128,40503175,10.1016/j.omtn.2025.102567,offtarget,siRNA,PubMed abstract sentence 4,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Targeting CIDEB alleviates liver steatosis and fibrosis in mouse MASH models.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting CIDEB alleviates liver steatosis and fibrosis in mouse MASH models.
13962,43131,40500390,10.1038/s43587-025-00895-1,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Using RNA therapeutics to promote healthy aging.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Using RNA therapeutics to promote healthy aging.
13965,43134,40498020,10.3390/cells14110843,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Soluble β-Amyloid Oligomers Selectively Upregulate TRPC3 in Excitatory Neurons via Calcineurin-Coupled NFAT.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Soluble β-Amyloid Oligomers Selectively Upregulate TRPC3 in Excitatory Neurons via Calcineurin-Coupled NFAT.
13979,43148,40485513,10.1039/d5em00224a,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: An environmentally relevant concentration of 6-PPD quinone inhibits two types of mitophagy to cause mitochondrial dysfunction and lifespan reduction in Caenorhabditis elegans .",B,high_candidate,curator_rejected,reject,derived_annotations_only,An environmentally relevant concentration of 6-PPD quinone inhibits two types of mitophagy to cause mitochondrial dysfunction and lifespan reduction in Caenorhabditis elegans.
13980,43149,40484286,10.1016/j.jneumeth.2025.110500,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of high-content screening assay for gene silencing in adult sensory neurons.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of high-content screening assay for gene silencing in adult sensory neurons.
13994,43163,40456202,10.1016/j.phymed.2025.156925,toxicity,siRNA,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Ponicidin triggered ferroptosis in esophageal squamous cell carcinoma by suppressing the SLC7A11/Glutathione/GPX4 signalling axis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Ponicidin triggered ferroptosis in esophageal squamous cell carcinoma by suppressing the SLC7A11/Glutathione/GPX4 signalling axis.
14000,43169,40450984,10.1016/j.phymed.2025.156908,toxicity,siRNA,PubMed abstract sentence 16,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Jianpi Huayu decoction enhances the antitumor effect of doxorubicin via piezo1-mediated autophagy in hepatocellular carcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Jianpi Huayu decoction enhances the antitumor effect of doxorubicin via piezo1-mediated autophagy in hepatocellular carcinoma.
14013,43182,40436348,10.1016/j.jconrel.2025.113881,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gene therapy and nanomedicine for meningioma treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gene therapy and nanomedicine for meningioma treatment.
14016,43185,40434251,10.1111/jcmm.70624,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Efficacy of Hellebrigenin Against Nasopharyngeal Carcinoma Cells: The Molecular and Bioinformatic Analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Efficacy of Hellebrigenin Against Nasopharyngeal Carcinoma Cells: The Molecular and Bioinformatic Analysis.
14023,43192,40424832,10.1016/j.biomaterials.2025.123420,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Precision nanomedicine for pneumonocyte-targeting: Emerging strategies and clinical prospects in refractory pulmonary disease therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Precision nanomedicine for pneumonocyte-targeting: Emerging strategies and clinical prospects in refractory pulmonary disease therapy.
14036,43205,40396399,10.1097/MOL.0000000000000998,toxicity,ASO,PubMed abstract sentence 3,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Lipoprotein(a) and peripheral artery disease: contemporary evidence and therapeutic advances.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lipoprotein(a) and peripheral artery disease: contemporary evidence and therapeutic advances.
14037,43206,40391085,10.1093/nargab/lqaf064,offtarget,siRNA,PubMed abstract sentence 6,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: dsRNAmax: a multi-target chimeric dsRNA designer for safe and effective crop protection.",B,high_candidate,curator_rejected,reject,derived_annotations_only,dsRNAmax: a multi-target chimeric dsRNA designer for safe and effective crop protection.
14044,43213,40383468,10.1016/j.cbi.2025.111564,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Stereoisomeric mitomycins interstrand crosslinks differently impact gene expression in MCF-7 and K562 cancer cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Stereoisomeric mitomycins interstrand crosslinks differently impact gene expression in MCF-7 and K562 cancer cells.
14048,43217,40377895,10.1007/s12035-025-05054-6,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Berberine can be a Potential Therapeutic Agent in Treatment of Huntington's Disease: A Proposed Mechanistic Insight.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Berberine can be a Potential Therapeutic Agent in Treatment of Huntington's Disease: A Proposed Mechanistic Insight.
14056,43225,40368879,10.1038/s41467-025-59494-8,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function.
14058,43227,40366533,10.1007/s10637-025-01534-7,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MicroRNA nanoformulation: a promising approach to anti-tumour activity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,MicroRNA nanoformulation: a promising approach to anti-tumour activity.
14059,43228,40365296,10.7150/thno.111400,toxicity,ASO,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Dual prophylactic and therapeutic potential of iPSC-based vaccines and neoantigen discovery in colorectal cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Dual prophylactic and therapeutic potential of iPSC-based vaccines and neoantigen discovery in colorectal cancer.
14063,43232,40352593,10.3389/fonc.2025.1489701,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Recent advances in therapeutic use of transforming growth factor-beta inhibitors in cancer and fibrosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Recent advances in therapeutic use of transforming growth factor-beta inhibitors in cancer and fibrosis.
14068,43237,40349468,10.1016/j.ecoenv.2025.118298,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Arsenic-induced circASXL1 regulates 16HBE cell proliferation through the P65 signaling axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Arsenic-induced circASXL1 regulates 16HBE cell proliferation through the P65 signaling axis.
14077,43246,40327939,10.1016/j.jhazmat.2025.138438,toxicity,siRNA,PubMed abstract sentence 2,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: Methotrexate-induced disruption of the serum-glucocorticoid inducible protein kinase 3 signaling pathway and its effects on brain development.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Methotrexate-induced disruption of the serum-glucocorticoid inducible protein kinase 3 signaling pathway and its effects on brain development.
14084,43253,40314119,10.1097/MNH.0000000000001082,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: APOL1 testing in clinical practice and opportunities for new therapies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,APOL1 testing in clinical practice and opportunities for new therapies.
14085,43254,40311681,10.1016/j.jbc.2025.108559,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Microbial metabolite ammonia disrupts TGF-β signaling to promote colon cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Microbial metabolite ammonia disrupts TGF-β signaling to promote colon cancer.
14096,43265,40297405,10.2147/IJN.S514375,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ROS-Responsive Biomimetic Nanocomplexes of Liposomes and Macrophage-Derived Exosomes for Combination Breast Cancer Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,ROS-Responsive Biomimetic Nanocomplexes of Liposomes and Macrophage-Derived Exosomes for Combination Breast Cancer Therapy.
14100,43269,40286451,10.1016/j.ejmech.2025.117641,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: N-(5-(2-morpholino-4-oxo-3,4-dihydroquinazolin-8-yl)pyridin-2-yl)acylamides as novel multi-PI3K/DNA-PK/P-gp inhibitors for efficient chemosensitization and MDR alleviation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"N-(5-(2-morpholino-4-oxo-3,4-dihydroquinazolin-8-yl)pyridin-2-yl)acylamides as novel multi-PI3K/DNA-PK/P-gp inhibitors for efficient chemosensitization and MDR alleviation."
14120,43289,40264356,10.1021/acsnano.4c18731,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gestational Exposure to Black Phosphorus Nanoparticles Induces Placental Trophoblast Dysfunction by Triggering Reactive Oxygen Species-Regulated Mitophagy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Gestational Exposure to Black Phosphorus Nanoparticles Induces Placental Trophoblast Dysfunction by Triggering Reactive Oxygen Species-Regulated Mitophagy.
14121,43290,40263592,10.1038/s41598-025-98418-w,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A novel approach in using insect-based spinach-food waste for gene targeting to cancer tissues.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A novel approach in using insect-based spinach-food waste for gene targeting to cancer tissues.
14125,43294,40246001,10.1016/j.cpcardiol.2025.103057,toxicity,siRNA,PubMed abstract sentence 6,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: RNA-targeting therapies for amyloid transthyretin cardiomyopathy: A systematic review and meta-analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA-targeting therapies for amyloid transthyretin cardiomyopathy: A systematic review and meta-analysis.
14133,43302,40236812,10.1016/j.mtbio.2025.101718,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bundling gold nanorods with RCA-produced DNA tape into an intelligently reconfigurable nanocluster bomb for multimodal precision cancer therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Bundling gold nanorods with RCA-produced DNA tape into an intelligently reconfigurable nanocluster bomb for multimodal precision cancer therapy.
14135,43304,40235854,10.1016/j.omtn.2025.102523,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Single-guide RNA Cas9 and enhanced-deletion Cas9 rescue a recurrent USH2A -related splicing defect.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Single-guide RNA Cas9 and enhanced-deletion Cas9 rescue a recurrent USH2A-related splicing defect.
14139,43308,40231656,10.1177/10600280251332500,toxicity,ASO,PubMed abstract sentence 8,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Olezarsen for the Treatment of Familial Chylomicronemia Syndrome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Olezarsen for the Treatment of Familial Chylomicronemia Syndrome.
14140,43309,40229422,10.1038/s41434-025-00532-x,offtarget,siRNA,PubMed abstract sentence 8,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: Development of an AAV-RNAi strategy to silence the dominant variant GNAO1 c.607G>A linked to encephalopathy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of an AAV-RNAi strategy to silence the dominant variant GNAO1 c.607G>A linked to encephalopathy.
14141,43310,40227445,10.3390/antiox14030344,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Novel Gastrodin Derivative with Neuroprotection Promotes NGF-Mimic Activity by Targeting INSR and ACTN4 to Activate PI3K/Akt Signaling Pathway in PC12 Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Novel Gastrodin Derivative with Neuroprotection Promotes NGF-Mimic Activity by Targeting INSR and ACTN4 to Activate PI3K/Akt Signaling Pathway in PC12 Cells.
14143,43312,40222106,10.1016/j.molpha.2025.100032,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Doxorubicin-induced apoptosis is exacerbated by MG53 and associated with altered Akt signaling in H9c2 cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Doxorubicin-induced apoptosis is exacerbated by MG53 and associated with altered Akt signaling in H9c2 cells.
14147,43316,40221009,10.1016/j.expneurol.2025.115253,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nicotinamide N-methyltransferase as a potential therapeutic target for neurodegenerative disorders: Mechanisms, challenges, and future directions.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Nicotinamide N-methyltransferase as a potential therapeutic target for neurodegenerative disorders: Mechanisms, challenges, and future directions."
14149,43318,40220706,10.1016/j.dmd.2025.100062,toxicity,siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluation of small interfering RNA-dependent knockdowns of drug-metabolizing enzymes in multiwell array culture of primary human hepatocyte spheroids for estimation of fraction metabolized.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Evaluation of small interfering RNA-dependent knockdowns of drug-metabolizing enzymes in multiwell array culture of primary human hepatocyte spheroids for estimation of fraction metabolized.
14151,43320,40220669,10.1016/j.plaphy.2025.109882,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Abscisic acid, stress and ripening (ASR) proteins play a role in iron homeostasis in rice (Oryza sativa L.).",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Abscisic acid, stress and ripening (ASR) proteins play a role in iron homeostasis in rice (Oryza sativa L.)."
14152,43321,40207978,10.1002/path.6422,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Utilizing aptamers in targeted protein degradation strategies for disease therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Utilizing aptamers in targeted protein degradation strategies for disease therapy.
14155,43324,40207309,10.2147/IJN.S501561,toxicity,siRNA,PubMed abstract sentence 16,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Si-ITGA6-Loaded Liposomes Inhibit Capsule Fibrosis via the FAK/PI3K/Akt Signaling Pathway in Adhesive Capsulitis of Shoulder.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Si-ITGA6-Loaded Liposomes Inhibit Capsule Fibrosis via the FAK/PI3K/Akt Signaling Pathway in Adhesive Capsulitis of Shoulder.
14159,43328,40202160,10.1039/d4mo00205a,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Human circulatory proteome interaction, oxidative stress-associated signalling and cardiovascular implications during titanium dioxide nanoparticle (TiO 2 -NP) exposure.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Human circulatory proteome interaction, oxidative stress-associated signalling and cardiovascular implications during titanium dioxide nanoparticle (TiO(2)-NP) exposure."
14169,43338,40190139,10.1002/ptr.8468,toxicity,siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Xanthohumol Regulates Mitophagy in Osteosarcoma Cells via AMPK-ULK1-FUNDC1 Signaling Pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Xanthohumol Regulates Mitophagy in Osteosarcoma Cells via AMPK-ULK1-FUNDC1 Signaling Pathway.
14170,43339,40187872,10.1016/j.aca.2025.343880,toxicity,ASO,PubMed abstract sentence 1,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: A portable and efficient strategy for ofloxacin detection using Ce-based MOF-loaded glucose oxidase and a personal glucose meter.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A portable and efficient strategy for ofloxacin detection using Ce-based MOF-loaded glucose oxidase and a personal glucose meter.
14173,43342,40184263,10.1021/acs.est.5c02110,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Contribution of Nilaparvata lugens Nicotinic Acetylcholine Receptor Subunits Toward Triflumezopyrim and Neonicotinoid Susceptibility.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Contribution of Nilaparvata lugens Nicotinic Acetylcholine Receptor Subunits Toward Triflumezopyrim and Neonicotinoid Susceptibility.
14179,43348,40177867,10.1158/1535-7163.MCT-24-1059,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer.
14183,43352,40166646,10.1002/mco2.70152,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: STAT3 Signaling Pathway in Health and Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,STAT3 Signaling Pathway in Health and Disease.
14191,43360,40149927,10.3390/biom15030391,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluation of Lipid-Based Transfection in Primary Monocytes Within an Ex Vivo Whole-Blood Model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluation of Lipid-Based Transfection in Primary Monocytes Within an Ex Vivo Whole-Blood Model.
14196,43365,40139601,10.1016/j.ijbiomac.2025.142486,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hyaluronic acid-functionalized nanomedicines for CD44-receptors-mediated targeted cancer therapy: A review of selective targetability and biodistribution to tumor microenvironment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hyaluronic acid-functionalized nanomedicines for CD44-receptors-mediated targeted cancer therapy: A review of selective targetability and biodistribution to tumor microenvironment.
14199,43368,40133195,10.3724/SP.J.1123.2024.04012,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: [Research advances in non-immobilized aptamer screening techniques for small-molecule targets].",B,high_candidate,curator_rejected,reject,derived_annotations_only,[Research advances in non-immobilized aptamer screening techniques for small-molecule targets].
14211,43380,40112899,10.1016/j.jconrel.2025.113644,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhalable pH-responsive charge-reversal polymer-small interfering RNA polyplexes for directed gene therapy of anaplastic lymphoma kinase fusion-positive lung cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Inhalable pH-responsive charge-reversal polymer-small interfering RNA polyplexes for directed gene therapy of anaplastic lymphoma kinase fusion-positive lung cancer.
14214,43383,40101890,10.1016/j.tox.2025.154121,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Thallium induces metallothionein gene expression in Huh-7 human hepatoma cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Thallium induces metallothionein gene expression in Huh-7 human hepatoma cells.
14222,43391,40078065,10.1039/d4nh00652f,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Framework nucleic acid-programmed aptamer-paclitaxel conjugates as targeted therapeutics for triple-negative breast cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Framework nucleic acid-programmed aptamer-paclitaxel conjugates as targeted therapeutics for triple-negative breast cancer.
14223,43392,40074987,10.1007/s40265-025-02166-0,toxicity,ASO,PubMed abstract sentence 4,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Olezarsen: First Approval.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Olezarsen: First Approval.
14224,43393,40074023,10.1016/j.neulet.2025.138193,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Intracellular metabotropic glutamate receptor 5 in spinal dorsal horn neurons contributes to pain in a mouse model of vincristine-induced neuropathic pain.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Intracellular metabotropic glutamate receptor 5 in spinal dorsal horn neurons contributes to pain in a mouse model of vincristine-induced neuropathic pain.
14232,43401,40060931,10.1016/j.omtn.2025.102479,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Potential ASO-based personalized treatment for Charcot-Marie-Tooth disease type 2S.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Potential ASO-based personalized treatment for Charcot-Marie-Tooth disease type 2S.
14237,43406,40057375,10.1093/nar/gkaf137,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A novel L-RNA aptamer to regulate the pUG fold RNA-induced gene expression in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A novel L-RNA aptamer to regulate the pUG fold RNA-induced gene expression in vivo.
14242,43411,40049439,10.1016/j.cbi.2025.111452,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chlorpyrifos-oxon results in autophagic flux dysfunction contributing to neuronal apoptosis via a ROS/AMPK/CHOP activation pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chlorpyrifos-oxon results in autophagic flux dysfunction contributing to neuronal apoptosis via a ROS/AMPK/CHOP activation pathway.
14243,43412,40046252,10.1039/d5na00044k,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advances in RNAi-based nanoformulations: revolutionizing crop protection and stress tolerance in agriculture.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in RNAi-based nanoformulations: revolutionizing crop protection and stress tolerance in agriculture.
14262,43431,40015874,10.1016/j.pestbp.2024.106282,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification of an α-galactosidase with high affinity and synergistic activity against Bacillus thuringiensis App6Aa2 toxin in Bursaphelenchus xylophilus.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identification of an α-galactosidase with high affinity and synergistic activity against Bacillus thuringiensis App6Aa2 toxin in Bursaphelenchus xylophilus.
14290,43459,39970724,10.1016/j.bios.2025.117273,offtarget,siRNA,PubMed abstract sentence 8,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Lighting up three-dimensional nanolantern for circular RNA imaging and precise gene therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lighting up three-dimensional nanolantern for circular RNA imaging and precise gene therapy.
14291,43460,39970724,10.1016/j.bios.2025.117273,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Lighting up three-dimensional nanolantern for circular RNA imaging and precise gene therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lighting up three-dimensional nanolantern for circular RNA imaging and precise gene therapy.
14297,43466,39964965,10.1093/cvr/cvaf022,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Thousand and one amino acid protein kinase 1 suppression improves doxorubicin-induced cardiomyopathy by preventing cardiomyocyte death and dysfunction.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Thousand and one amino acid protein kinase 1 suppression improves doxorubicin-induced cardiomyopathy by preventing cardiomyocyte death and dysfunction.
14310,43479,39946362,10.1371/journal.pone.0317559,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Multifunctional molecular hybrid for targeted colorectal cancer cells: Integrating doxorubicin, AS1411 aptamer, and T9/U4 ASO.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Multifunctional molecular hybrid for targeted colorectal cancer cells: Integrating doxorubicin, AS1411 aptamer, and T9/U4 ASO."
14315,43484,39930790,10.1002/adhm.202404781,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy.
14325,43494,39904427,10.1016/j.ijbiomac.2025.140634,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transcription factor CREB/ATF regulates overexpression of CYP6CY14 conferring resistance to cycloxaprid in Aphis gossypii.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Transcription factor CREB/ATF regulates overexpression of CYP6CY14 conferring resistance to cycloxaprid in Aphis gossypii.
14328,43497,39900327,10.1016/j.ejphar.2025.177346,offtarget,ASO/siRNA,PubMed abstract sentence 9,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Therapeutic inhibition of PHF21B attenuates pathological cardiac hypertrophy by inhibiting the BMP4/GSK3β/β-catenin axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Therapeutic inhibition of PHF21B attenuates pathological cardiac hypertrophy by inhibiting the BMP4/GSK3β/β-catenin axis.
14331,43500,39890761,10.1007/s44211-025-00722-y,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Analytical techniques for arsenic speciation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Analytical techniques for arsenic speciation.
14334,43503,39884591,10.1016/j.ijpharm.2025.125294,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Nucleolin-targeted silicon-based nanoparticles for enhanced chemo-sonodynamic therapy of diffuse large B-cell lymphoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nucleolin-targeted silicon-based nanoparticles for enhanced chemo-sonodynamic therapy of diffuse large B-cell lymphoma.
14341,43510,39851793,10.3390/clinpract15010010,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Distribution of Major HLA-A, -B, -DR, and -DQ Loci Potentially Associated with Multiple Sclerosis in a Healthy Population from Southern Morocco.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Distribution of Major HLA-A, -B, -DR, and -DQ Loci Potentially Associated with Multiple Sclerosis in a Healthy Population from Southern Morocco."
14347,43516,39838063,10.1038/s43856-024-00712-7,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Preclinical assessment of splicing modulation therapy for ABCA4 variant c.768G>T in Stargardt disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preclinical assessment of splicing modulation therapy for ABCA4 variant c.768G>T in Stargardt disease.
14350,43519,39827759,10.1016/j.jcis.2025.01.107,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoparticles (NPs)-mediated silencing of GSTP1 expression to reverse chemoresistance for effective breast cancer therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Nanoparticles (NPs)-mediated silencing of GSTP1 expression to reverse chemoresistance for effective breast cancer therapy.
14352,43521,39820813,10.1038/s41587-024-02535-2,offtarget,ASO/siRNA,PubMed abstract sentence 4,off-target;transcriptome,"offtarget candidate; matched derived terms: off-target, transcriptome; source title: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy.
14353,43522,39820813,10.1038/s41587-024-02535-2,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy.
14355,43524,39815031,10.1038/s42003-024-07351-7,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication.",B,high_candidate,curator_rejected,reject,derived_annotations_only,G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication.
14357,43526,39809473,10.1021/acs.molpharmaceut.4c00917,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MRI-Based Multifunctional Nanoliposomes for Enhanced HCC Therapy and Diagnosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,MRI-Based Multifunctional Nanoliposomes for Enhanced HCC Therapy and Diagnosis.
14365,43534,39790038,10.1002/adhm.202404159,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Smart mRNA-Initiated Theranostic Multi-shRNA Nanofactory for Precise and Efficient Cancer Gene Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Smart mRNA-Initiated Theranostic Multi-shRNA Nanofactory for Precise and Efficient Cancer Gene Therapy.
14368,43537,39779500,10.1007/s10735-024-10342-x,offtarget,ASO/siRNA,PubMed abstract sentence 5,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Activation of the WNT4/ β-catenin/FOXO1 pathway by PDK1 promotes cervical cancer metastasis and EMT process.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Activation of the WNT4/ β-catenin/FOXO1 pathway by PDK1 promotes cervical cancer metastasis and EMT process.
14372,43541,39772484,10.1021/acs.accounts.4c00580,toxicity,ASO,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sequence-Defined DNA Polymers: New Tools for DNA Nanotechnology and Nucleic Acid Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sequence-Defined DNA Polymers: New Tools for DNA Nanotechnology and Nucleic Acid Therapy.
14386,43555,39701373,10.1016/j.drudis.2024.104275,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: How can MSI enhance our understanding of ASO distribution?",B,high_candidate,curator_rejected,reject,derived_annotations_only,How can MSI enhance our understanding of ASO distribution?
14387,43556,39698891,10.1111/acel.14422,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A subset of human dermal fibroblasts overexpressing Cockayne syndrome group B protein resist UVB radiation-mediated premature senescence.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A subset of human dermal fibroblasts overexpressing Cockayne syndrome group B protein resist UVB radiation-mediated premature senescence.
14389,43558,39667456,10.1016/j.ijbiomac.2024.138621,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Graphene/carbohydrate polymer composites as emerging hybrid materials in tumor therapy and diagnosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Graphene/carbohydrate polymer composites as emerging hybrid materials in tumor therapy and diagnosis.
14390,43559,39661279,10.1007/s10620-024-08734-w,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cell Type-Preferential Expression of Peptidylarginine Deiminase 4 and p53-Dependent Therapeutic Vulnerabilities in Gastric Cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cell Type-Preferential Expression of Peptidylarginine Deiminase 4 and p53-Dependent Therapeutic Vulnerabilities in Gastric Cancer.
14393,43562,39654412,10.47936/encephalitis.2024.00122,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tandem repeat disorders: from diagnosis to emerging therapeutic strategies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tandem repeat disorders: from diagnosis to emerging therapeutic strategies.
14397,43566,39586487,10.1016/j.tox.2024.154014,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tetrabromobisphenol A induced p38-MAPK/AMPKα activation downstream-triggered CHOP signal contributing to neuronal apoptosis and death.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Tetrabromobisphenol A induced p38-MAPK/AMPKα activation downstream-triggered CHOP signal contributing to neuronal apoptosis and death.
14398,43567,39580141,10.1016/j.lfs.2024.123258,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cardiac-specific Suv39h1 knockout ameliorates high-fat diet induced diabetic cardiomyopathy via regulating Hmox1 transcription.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cardiac-specific Suv39h1 knockout ameliorates high-fat diet induced diabetic cardiomyopathy via regulating Hmox1 transcription.
14399,43568,39576590,10.1007/978-1-0716-4196-5_19,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Glimpse of Noncoding RNAs: Secondary Structure, Emerging Trends, and Potential Applications in Human Diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"A Glimpse of Noncoding RNAs: Secondary Structure, Emerging Trends, and Potential Applications in Human Diseases."
14407,43576,39504794,10.1016/j.ejmech.2024.117027,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of hybrid aptamers-engineered PROTACs for degrading VEGF165 in both tumor- and vascular endothelial cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of hybrid aptamers-engineered PROTACs for degrading VEGF165 in both tumor- and vascular endothelial cells.
14410,43579,39475588,10.1094/PDIS-07-24-1367-RE,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Postharvest Chitosan Sprays Reduce Bitter Rot and Blue Mold on Apple Fruit.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Postharvest Chitosan Sprays Reduce Bitter Rot and Blue Mold on Apple Fruit.
14421,43590,39304616,10.1007/s40256-024-00682-0,toxicity,ASO/siRNA,PubMed abstract sentence 1,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Efficacy of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Patients with Heterozygous Familial Hypercholesterolemia: A Meta-analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficacy of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Patients with Heterozygous Familial Hypercholesterolemia: A Meta-analysis.
14425,43594,39257305,10.1111/pce.15152,offtarget,siRNA,PubMed abstract sentence 3,seed;silencing,"offtarget candidate; matched derived terms: seed, silencing; source title: OsRHS Negatively Regulates Rice Heat Tolerance at the Flowering Stage by Interacting With the HSP Protein cHSP70-4.",B,high_candidate,curator_rejected,reject,derived_annotations_only,OsRHS Negatively Regulates Rice Heat Tolerance at the Flowering Stage by Interacting With the HSP Protein cHSP70-4.
14437,43606,38385680,10.1097/CRD.0000000000000645,toxicity,siRNA,PubMed abstract sentence 8,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Zilebesiran: A Promising Antihypertensive Therapy Inhibiting Angiotensinogen Synthesis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Zilebesiran: A Promising Antihypertensive Therapy Inhibiting Angiotensinogen Synthesis.
14451,43620,39735543,10.3389/fimmu.2024.1501365,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In vivo programmed myeloid cells expressing novel chimeric antigen receptors show potent anti-tumor activity in preclinical solid tumor models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In vivo programmed myeloid cells expressing novel chimeric antigen receptors show potent anti-tumor activity in preclinical solid tumor models.
14456,43625,39713235,10.1016/j.ijcchd.2024.100550,toxicity,ASO,PubMed abstract sentence 8,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries.
14460,43629,39676860,10.3389/fimmu.2024.1491230,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Effective inhibition of dengue virus replication using 3'UTR-targeted Vivo-Morpholinos.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Effective inhibition of dengue virus replication using 3'UTR-targeted Vivo-Morpholinos.
14461,43630,39676736,10.1002/jev2.70025,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CD7-targeting pro-apoptotic extracellular vesicles: A novel approach for T-cell haematological malignancy therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CD7-targeting pro-apoptotic extracellular vesicles: A novel approach for T-cell haematological malignancy therapy.
14464,43633,39638605,10.1080/22221751.2024.2429624,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification of cepharanthine as an effective inhibitor of African swine fever virus replication.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Identification of cepharanthine as an effective inhibitor of African swine fever virus replication.
14467,43636,39619006,10.1016/j.cjcpc.2024.08.004,toxicity,ASO,PubMed abstract sentence 9,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: The Need for Preoperative Prostaglandin E1 for d-Transposition After Balloon Atrial Septostomy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Need for Preoperative Prostaglandin E1 for d-Transposition After Balloon Atrial Septostomy.
14474,43643,39596149,10.3390/ijms252212081,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Adeno-Associated Viral Vectors in the Treatment of Epilepsy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Adeno-Associated Viral Vectors in the Treatment of Epilepsy.
14477,43646,39588258,10.2147/IJN.S476546,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: SFRP1-Silencing GapmeR-Loaded Lipid-Polymer Hybrid Nanoparticles for Bone Regeneration in Osteoporosis: Effect of Dosing and Targeting Strategy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,SFRP1-Silencing GapmeR-Loaded Lipid-Polymer Hybrid Nanoparticles for Bone Regeneration in Osteoporosis: Effect of Dosing and Targeting Strategy.
14479,43648,39579127,10.1021/acs.est.4c06892,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Genetic Evidence for Estrogenic Effects of Benzophenone-2 on Zebrafish Neurodevelopment and Its Signaling Mechanism.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Genetic Evidence for Estrogenic Effects of Benzophenone-2 on Zebrafish Neurodevelopment and Its Signaling Mechanism.
14481,43650,39574582,10.1101/2024.11.04.619693,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.
14486,43655,39555853,10.1111/cts.70076,toxicity,ASO,PubMed abstract sentence 3,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Imetelstat, a novel, first-in-class telomerase inhibitor: Mechanism of action, clinical, and translational science.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Imetelstat, a novel, first-in-class telomerase inhibitor: Mechanism of action, clinical, and translational science."
14500,43669,39484778,10.1039/d4ay01540a,toxicity,ASO,PubMed abstract sentence 10,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Digoxin detection for therapeutic drug monitoring using target-triggered aptamer hairpin switch and nicking enzyme-assisted signal amplification.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Digoxin detection for therapeutic drug monitoring using target-triggered aptamer hairpin switch and nicking enzyme-assisted signal amplification.
14503,43672,39477575,10.1016/j.pestbp.2024.106114,offtarget,siRNA,PubMed abstract sentence 7,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Design the fusion double-strand RNAs to control two global sap-sucking pests.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Design the fusion double-strand RNAs to control two global sap-sucking pests.
14510,43679,39458966,10.3390/ph17101325,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: In Vivo HOXB7 Gene Silencing and Cotreatment with Tamoxifen for Luminal A Breast Cancer Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In Vivo HOXB7 Gene Silencing and Cotreatment with Tamoxifen for Luminal A Breast Cancer Therapy.
14514,43683,39437434,10.1021/acs.jmedchem.4c01228,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Design of Murine Double Minute 2 Proteolysis Targeting Chimera Degraders with a Built-In Tumor-Targeting Ability.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Design of Murine Double Minute 2 Proteolysis Targeting Chimera Degraders with a Built-In Tumor-Targeting Ability.
14527,43696,39376088,10.1021/acs.bioconjchem.4c00376,toxicity,ASO,PubMed abstract sentence 2,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Inhibitory Effects on RNA Binding and RNase H Induction Activity of Prodrug-Type Oligodeoxynucleotides Modified with a Galactosylated Self-Immolative Linker Cleavable by β-Galactosidase.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibitory Effects on RNA Binding and RNase H Induction Activity of Prodrug-Type Oligodeoxynucleotides Modified with a Galactosylated Self-Immolative Linker Cleavable by β-Galactosidase.
14543,43712,39321527,10.1016/j.ecoenv.2024.117104,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Di-(2-ethylhexyl) phthalate exposure induces ferroptosis by regulating the Nrf2-mediated signaling pathway in mouse ovaries.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Di-(2-ethylhexyl) phthalate exposure induces ferroptosis by regulating the Nrf2-mediated signaling pathway in mouse ovaries.
14555,43724,39263430,10.1039/d4ra03823a,toxicity,siRNA,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Therapeutic applications of RNA nanostructures.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Therapeutic applications of RNA nanostructures.
14559,43728,39245217,10.1016/j.chemosphere.2024.143293,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Prevalence of perturbed gut microbiota in pathophysiology of arsenic-induced anxiety- and depression-like behaviour in mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Prevalence of perturbed gut microbiota in pathophysiology of arsenic-induced anxiety- and depression-like behaviour in mice.
14574,43743,39199337,10.3390/biom14080949,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Novel Therapeutic Horizons: SNCA Targeting in Parkinson's Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Novel Therapeutic Horizons: SNCA Targeting in Parkinson's Disease.
14579,43748,39179327,10.1016/j.jgeb.2024.100400,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Current developments of SELEX technologies and prospects in the aptamer selection with clinical applications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Current developments of SELEX technologies and prospects in the aptamer selection with clinical applications.
14582,43751,39170125,10.1016/j.heliyon.2024.e34963,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The prion-like effect and prion-like protein targeting strategy in amyotrophic lateral sclerosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The prion-like effect and prion-like protein targeting strategy in amyotrophic lateral sclerosis.
14587,43756,39141942,10.1016/j.jhazmat.2024.135375,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: 1,2-bis(2,4,6-tribromophenoxy) ethane induces necroptosis via the co-competition of GAS5 and NUAK1 for miR-743a-5p in rat hepatocytes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"1,2-bis(2,4,6-tribromophenoxy) ethane induces necroptosis via the co-competition of GAS5 and NUAK1 for miR-743a-5p in rat hepatocytes."
14590,43759,39136161,10.1039/d4dt01075b,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Unravelling the mechanism of apoptosis induced by copper(II) complexes of NN 2 -pincer ligands in lung cancer cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Unravelling the mechanism of apoptosis induced by copper(II) complexes of NN(2)-pincer ligands in lung cancer cells.
14593,43762,39128820,10.1016/j.lfs.2024.122954,toxicity,siRNA,PubMed abstract sentence 9,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Current insights and therapeutic strategies for targeting TRPV1 in neuropathic pain management.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Current insights and therapeutic strategies for targeting TRPV1 in neuropathic pain management.
14604,43773,39101472,10.1093/eurjpc/zwae254,toxicity,siRNA,PubMed abstract sentence 2,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme.
14615,43784,39052063,10.1007/s00011-024-01921-5,toxicity,ASO,PubMed abstract sentence 10,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Pharmacological targeting of adaptor proteins in chronic inflammation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pharmacological targeting of adaptor proteins in chronic inflammation.
14619,43788,39045516,10.1016/j.omtn.2024.102258,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Circular RNA-based therapy provides sustained and robust neuroprotection for retinal ganglion cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Circular RNA-based therapy provides sustained and robust neuroprotection for retinal ganglion cells.
14631,43800,39008248,10.1007/978-1-0716-4043-2_4,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Proximity Ligation Assay for the Analysis of Iron-Mediated Protein-Protein Interactions in the Nucleus.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Proximity Ligation Assay for the Analysis of Iron-Mediated Protein-Protein Interactions in the Nucleus.
14634,43803,39004389,10.1016/j.cbi.2024.111143,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Isoxazolyl-urea derivative evokes apoptosis and paraptosis by abrogating the Wnt/β-catenin axis in colon cancer cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Isoxazolyl-urea derivative evokes apoptosis and paraptosis by abrogating the Wnt/β-catenin axis in colon cancer cells.
14640,43809,38992100,10.1038/s41389-024-00525-2,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients.
14641,43810,38984712,10.20452/pamw.16799,toxicity,ASO,PubMed abstract sentence 8,safety;risk;tolerability,"toxicity candidate; matched derived terms: safety, risk, tolerability; source title: Factor XI inhibition in cardiovascular disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Factor XI inhibition in cardiovascular disease.
14643,43812,38976714,10.1371/journal.ppat.1012344,toxicity,siRNA,PubMed abstract sentence 1,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction.
14645,43814,38974616,10.1002/jmd2.12435,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Two successful pregnancies -in patients taking Volanesorsen for familial chylomicronemia syndrome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Two successful pregnancies -in patients taking Volanesorsen for familial chylomicronemia syndrome.
14647,43816,38968904,10.1016/j.bioorg.2024.107595,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNase H-sensitive multifunctional ASO-based constructs as promising tools for the treatment of multifactorial complex pathologies.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RNase H-sensitive multifunctional ASO-based constructs as promising tools for the treatment of multifactorial complex pathologies.
14660,43829,38921951,10.3390/neurolint16030047,toxicity,ASO,PubMed abstract sentence 5,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Nusinersen Treatment for Spinal Muscular Atrophy: Retrospective Multicenter Study of Pediatric and Adult Patients in Kuwait.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Nusinersen Treatment for Spinal Muscular Atrophy: Retrospective Multicenter Study of Pediatric and Adult Patients in Kuwait.
14668,43837,38894941,10.3389/fnins.2024.1422442,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Spinocerebellar ataxias: from pathogenesis to recent therapeutic advances.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Spinocerebellar ataxias: from pathogenesis to recent therapeutic advances.
14674,43843,38879342,10.1016/j.pestbp.2024.105960,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification and transcriptional response of ATP-binding cassette transporters to beta-cypermethrin in the poultry red mite, Dermanyssus gallinae.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Identification and transcriptional response of ATP-binding cassette transporters to beta-cypermethrin in the poultry red mite, Dermanyssus gallinae."
14681,43850,38863261,10.1002/cpt.3341,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advances in Clinical Therapies for Huntington's Disease and the Promise of Multi-Targeted/Functional Drugs Based on Clinicaltrials.gov.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in Clinical Therapies for Huntington's Disease and the Promise of Multi-Targeted/Functional Drugs Based on Clinicaltrials.gov.
14682,43851,38861215,10.1007/s11910-024-01345-y,toxicity,ASO,PubMed abstract sentence 7,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Huntington's Disease: Latest Frontiers in Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Huntington's Disease: Latest Frontiers in Therapeutics.
14684,43853,38859589,10.1016/j.ymthe.2024.06.006,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting PD-L1 in cholangiocarcinoma using nanovesicle-based immunotherapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting PD-L1 in cholangiocarcinoma using nanovesicle-based immunotherapy.
14691,43860,38819691,10.1021/acs.accounts.4c00190,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoinjection: A Platform for Innovation in Ex Vivo Cell Engineering.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Nanoinjection: A Platform for Innovation in Ex Vivo Cell Engineering.
14692,43861,38819301,10.1042/CS20220530,toxicity,ASO,PubMed abstract sentence 4,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Precision diagnostics in transplanted organs using microarray-assessed gene expression: concepts and technical methods of the Molecular Microscope® Diagnostic System (MMDx).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Precision diagnostics in transplanted organs using microarray-assessed gene expression: concepts and technical methods of the Molecular Microscope® Diagnostic System (MMDx).
14698,43867,38811338,10.1016/j.scib.2024.05.017,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer.
14708,43877,38795878,10.1016/j.ijbiomac.2024.132455,toxicity,siRNA,PubMed abstract sentence 4,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Spraying double-stranded RNA targets UDP-N-acetylglucosamine pyrophosphorylase in the control of Nilaparvata lugens.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Spraying double-stranded RNA targets UDP-N-acetylglucosamine pyrophosphorylase in the control of Nilaparvata lugens.
14711,43880,38785527,10.3390/cimb46050259,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Membrane Association of the Short Transglutaminase Type 2 Splice Variant (TG2-S) Modulates Cisplatin Resistance in a Human Hepatocellular Carcinoma (HepG2) Cell Line.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Membrane Association of the Short Transglutaminase Type 2 Splice Variant (TG2-S) Modulates Cisplatin Resistance in a Human Hepatocellular Carcinoma (HepG2) Cell Line.
14714,43883,38778431,10.1111/eci.14254,toxicity,siRNA,PubMed abstract sentence 7,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: New insights into the therapeutic options to lower lipoprotein(a).",B,high_candidate,curator_rejected,reject,derived_annotations_only,New insights into the therapeutic options to lower lipoprotein(a).
14716,43885,38776818,10.1016/j.jhazmat.2024.134627,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Eliminating the stabilizer antagonistic effects for efficiently stabilizing Pb and As co-contaminated soil by innovative stepwise steam flash heating.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Eliminating the stabilizer antagonistic effects for efficiently stabilizing Pb and As co-contaminated soil by innovative stepwise steam flash heating.
14717,43886,38775471,10.1002/ps.8181,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: UGT201H1 overexpression confers cyflumetofen resistance in Tetranychus cinnabarinus (Boisduval).",B,high_candidate,curator_rejected,reject,derived_annotations_only,UGT201H1 overexpression confers cyflumetofen resistance in Tetranychus cinnabarinus (Boisduval).
14719,43888,38768701,10.1016/j.tox.2024.153831,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: NCOA4-mediated ferritinophagy participates in cadmium-triggered ferroptosis in spermatogonia.",B,high_candidate,curator_rejected,reject,derived_annotations_only,NCOA4-mediated ferritinophagy participates in cadmium-triggered ferroptosis in spermatogonia.
14739,43908,38710382,10.1016/j.tox.2024.153825,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ROS-mediated NRF2/p-ERK1/2 signaling-involved mitophagy contributes to macrophages activation induced by CdTe quantum dots.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ROS-mediated NRF2/p-ERK1/2 signaling-involved mitophagy contributes to macrophages activation induced by CdTe quantum dots.
14760,43929,38658865,10.1186/s12885-024-12286-7,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Homoharringtonine enhances cytarabine-induced apoptosis in acute myeloid leukaemia by regulating the p38 MAPK/H2AX/Mcl-1 axis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Homoharringtonine enhances cytarabine-induced apoptosis in acute myeloid leukaemia by regulating the p38 MAPK/H2AX/Mcl-1 axis.
14761,43930,38657608,10.1016/j.chembiol.2024.03.011,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Repurposing AS1411 for constructing ANM-PROTACs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Repurposing AS1411 for constructing ANM-PROTACs.
14766,43935,38638435,10.3389/fimmu.2024.1357072,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Arginine alleviates Clostridium perfringens α toxin-induced intestinal injury in vivo and in vitro via the SLC38A9/mTORC1 pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Arginine alleviates Clostridium perfringens α toxin-induced intestinal injury in vivo and in vitro via the SLC38A9/mTORC1 pathway.
14767,43936,38626492,10.1016/j.bioorg.2024.107367,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: 13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1.
14781,43950,38577537,10.4254/wjh.v16.i3.331,toxicity,siRNA,PubMed abstract sentence 4,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents.
14785,43954,38568291,10.1007/s12017-024-08775-4,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin-Proteasome System Activation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin-Proteasome System Activation.
14787,43956,38558246,10.1111/cas.16150,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta.
14795,43964,38548160,10.1016/j.envpol.2024.123846,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Dibutyl phthalate exposure induced mitochondria-dependent ferroptosis by enhancing VDAC2 in zebrafish ZF4 cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dibutyl phthalate exposure induced mitochondria-dependent ferroptosis by enhancing VDAC2 in zebrafish ZF4 cells.
14797,43966,38545650,10.1152/ajprenal.00014.2024,toxicity,ASO/siRNA,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MFSD12 depletion reduces cystine accumulation without improvement in proximal tubular function in experimental models for cystinosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,MFSD12 depletion reduces cystine accumulation without improvement in proximal tubular function in experimental models for cystinosis.
14800,43969,38532802,10.1177/17562864241239755,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Patisiran exposure in early pregnancy: a case report.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Patisiran exposure in early pregnancy: a case report.
14809,43978,38465810,10.17116/jnevro202412402145,toxicity,ASO,PubMed abstract sentence 15,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: [Risdiplam for the treatment of spinal muscular atrophy].",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,[Risdiplam for the treatment of spinal muscular atrophy].
14817,43986,38452197,10.1182/blood.2023021864,toxicity,ASO/siRNA,PubMed abstract sentence 6,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Fitusiran prophylaxis in people with hemophilia A or B who switched from prior BPA/CFC prophylaxis: the ATLAS-PPX trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Fitusiran prophylaxis in people with hemophilia A or B who switched from prior BPA/CFC prophylaxis: the ATLAS-PPX trial.
14822,43991,38442139,10.1080/09553002.2024.2324475,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway.
14826,43995,38429789,10.1186/s13058-024-01799-5,toxicity,ASO/siRNA,PubMed abstract sentence 16,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Overcoming doxorubicin resistance in triple-negative breast cancer using the class I-targeting HDAC inhibitor bocodepsin/OKI-179 to promote apoptosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Overcoming doxorubicin resistance in triple-negative breast cancer using the class I-targeting HDAC inhibitor bocodepsin/OKI-179 to promote apoptosis.
14830,43999,38407513,10.1002/anie.202402405,toxicity,ASO,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Catechol-Siderophore Mimics Convey Nucleic Acid Therapeutics into Bacteria.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Catechol-Siderophore Mimics Convey Nucleic Acid Therapeutics into Bacteria.
14842,44011,38383439,10.1186/s12943-024-01955-7,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.
14861,44030,38351187,10.1038/s41591-024-02808-y,toxicity,ASO,PubMed abstract sentence 9,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial.
14865,44034,38332115,10.1093/mutage/geae002,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Next-generation therapeutics for rare genetic disorders.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Next-generation therapeutics for rare genetic disorders.
14867,44036,38331433,10.1021/acs.jmedchem.3c01874,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Probing the Mechanism of Action of Bis(phenolato) Amine (ONO Donor Set) Titanium(IV) Anticancer Agents.
14874,44043,38310055,10.1016/j.ijbiomac.2024.129876,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Suppression of SOCS3 expression in macrophage cells: Potential application in diabetic wound healing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Suppression of SOCS3 expression in macrophage cells: Potential application in diabetic wound healing.
14890,44059,38267192,10.1016/S1474-4422(23)00419-2,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Challenges and opportunities in spinal muscular atrophy therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Challenges and opportunities in spinal muscular atrophy therapeutics.
14892,44061,38254683,10.3390/biom14010083,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Harnessing Nanotechnology: Emerging Strategies for Multiple Myeloma Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Harnessing Nanotechnology: Emerging Strategies for Multiple Myeloma Therapy.
14894,44063,38252335,10.1007/s40265-023-01987-1,toxicity,ASO/siRNA,PubMed abstract sentence 7,adverse;tolerability,"toxicity candidate; matched derived terms: adverse, tolerability; source title: Lumasiran: A Review in Primary Hyperoxaluria Type 1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lumasiran: A Review in Primary Hyperoxaluria Type 1.
14896,44065,38239495,10.2903/j.efsa.2024.8483,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Assessment of genetically modified maize DP23211 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2019-163).",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Assessment of genetically modified maize DP23211 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2019-163)."
14899,44068,38220483,10.1016/j.clinthera.2023.12.003,toxicity,ASO/siRNA,PubMed abstract sentence 12,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: First Report of Inclisiran Utilization for Hypercholesterolemia Treatment in Real-world Clinical Settings in a Middle East Population.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,First Report of Inclisiran Utilization for Hypercholesterolemia Treatment in Real-world Clinical Settings in a Middle East Population.
14918,44087,38110839,10.1002/ana.26860,toxicity,ASO,PubMed abstract sentence 3,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Biomarker Qualification for Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: Theory and Practice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Biomarker Qualification for Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: Theory and Practice.
14922,44091,38070266,10.1016/j.jhazmat.2023.133169,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A novel ratiometric electrochemical aptasensor based on M-shaped functional DNA complexes for simultaneous detection of trace lead and mercury ions in series aquatic edible vegetables.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A novel ratiometric electrochemical aptasensor based on M-shaped functional DNA complexes for simultaneous detection of trace lead and mercury ions in series aquatic edible vegetables.
14926,44095,38040199,10.1016/j.antiviral.2023.105767,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: Blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: Blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope.
14927,44096,38039754,10.1016/j.biopha.2023.115960,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Novel ASO therapeutic target designed against hyperlipidemia via PCSK9 knockdown.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Novel ASO therapeutic target designed against hyperlipidemia via PCSK9 knockdown.
14932,44101,37979722,10.1016/j.ihj.2023.11.003,toxicity,siRNA,PubMed abstract sentence 12,toxicity;toxic;risk;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, risk, hepatotoxicity; source title: Traditional and novel non-statin lipid-lowering drugs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Traditional and novel non-statin lipid-lowering drugs.
14935,44104,37951450,10.1016/j.ijbiomac.2023.127909,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Design, synthesis and anticancer evaluation of novel arylhydrazones of active methylene compounds.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Design, synthesis and anticancer evaluation of novel arylhydrazones of active methylene compounds."
14943,44112,37839227,10.1016/j.phymed.2023.155128,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transcriptomics and molecular docking reveal the potential mechanism of lycorine against pancreatic cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transcriptomics and molecular docking reveal the potential mechanism of lycorine against pancreatic cancer.
14946,44115,37757694,10.1016/j.talanta.2023.125244,toxicity,ASO,PubMed abstract sentence 2,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: Aptamer-thrombin loaded magnetic microspheres for bio-specific extraction and precise detection of hirudin.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamer-thrombin loaded magnetic microspheres for bio-specific extraction and precise detection of hirudin.
14951,44120,37518857,10.1002/smll.202301776,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development and Perspectives: Multifunctional Nucleic Acid Nanomedicines for Treatment of Gynecological Cancers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development and Perspectives: Multifunctional Nucleic Acid Nanomedicines for Treatment of Gynecological Cancers.
14958,44127,38203499,10.3390/ijms25010328,toxicity,siRNA,PubMed abstract sentence 7,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Molecular Therapies in Cardiovascular Diseases: Small Interfering RNA in Atherosclerosis, Heart Failure, and Hypertension.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Molecular Therapies in Cardiovascular Diseases: Small Interfering RNA in Atherosclerosis, Heart Failure, and Hypertension."
14960,44129,38136622,10.3390/biom13121751,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Method for Using Cell-Penetrating Peptides for Loading Plasmid DNA into Secreted Extracellular Vesicles.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Method for Using Cell-Penetrating Peptides for Loading Plasmid DNA into Secreted Extracellular Vesicles.
14965,44134,38095348,10.1080/10717544.2023.2180112,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Application of mPEG-CS-cRGD/ Bmi-1RNAi -PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Application of mPEG-CS-cRGD/Bmi-1RNAi-PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells.
14967,44136,38077055,10.21203/rs.3.rs-1297358/v3,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The therapeutically actionable long non-coding RNA ' T-RECS ' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The therapeutically actionable long non-coding RNA 'T-RECS' is essential to cancer cells' survival in NRAS/MAPK-driven melanoma.
14975,44144,38015828,10.1371/journal.pone.0294731,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice.
14977,44146,38001861,10.3390/antiox12112008,toxicity,ASO/siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pectolinarigenin Improves Oxidative Stress and Apoptosis in Mouse NSC-34 Motor Neuron Cell Lines Induced by C9-ALS-Associated Proline-Arginine Dipeptide Repeat Proteins by Enhancing Mitochondrial Fusion Mediated via the SIRT3/OPA1 Axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pectolinarigenin Improves Oxidative Stress and Apoptosis in Mouse NSC-34 Motor Neuron Cell Lines Induced by C9-ALS-Associated Proline-Arginine Dipeptide Repeat Proteins by Enhancing Mitochondrial Fusion Mediated via the SIRT3/OPA1 Axis.
14981,44150,37977258,10.1016/j.fct.2023.114177,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: ZnO nanoparticles impair autophagic flux and cell viability through the TRIM16-NRF2-p62 pathway in inflammatory keratinocytes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ZnO nanoparticles impair autophagic flux and cell viability through the TRIM16-NRF2-p62 pathway in inflammatory keratinocytes.
14985,44154,37962485,10.1002/cpz1.923,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Convenient Method for the Synthesis of 2'-O-Cyanoethylated Nucleotides and Their Application in the Solid-Phase Synthesis of Related RNA Analogs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A Convenient Method for the Synthesis of 2'-O-Cyanoethylated Nucleotides and Their Application in the Solid-Phase Synthesis of Related RNA Analogs.
14987,44156,37958473,10.3390/cancers15215300,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aptamers as Potential Therapeutic Tools for Ovarian Cancer: Advancements and Challenges.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamers as Potential Therapeutic Tools for Ovarian Cancer: Advancements and Challenges.
15001,44170,37892241,10.3390/biom13101559,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Designing Nanomedicines for Breast Cancer Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Designing Nanomedicines for Breast Cancer Therapy.
15003,44172,37860278,10.1080/2162402X.2023.2255041,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Preclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody.
15007,44176,37836816,10.3390/molecules28196973,toxicity,ASO,PubMed abstract sentence 1,toxic;risk,"toxicity candidate; matched derived terms: toxic, risk; source title: Sensitive Silver-Enhanced Microplate Apta-Enzyme Assay of Sb 3+ Ions in Drinking and Natural Waters.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Sensitive Silver-Enhanced Microplate Apta-Enzyme Assay of Sb(3+) Ions in Drinking and Natural Waters.
15013,44182,37808518,10.3389/fmolb.2023.1217769,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Anti-nucleolin aptamer AS1411: an advancing therapeutic.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Anti-nucleolin aptamer AS1411: an advancing therapeutic.
15019,44188,37769581,10.1016/j.ecoenv.2023.115526,toxicity,siRNA,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification of the Kupffer cell-derived circulating IGFBP-3 as a universal radiation biomarker for heavy ion, proton, and X-ray exposure.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Identification of the Kupffer cell-derived circulating IGFBP-3 as a universal radiation biomarker for heavy ion, proton, and X-ray exposure."
15025,44194,37744174,10.1016/j.omtn.2023.09.001,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression.
15053,44222,37611852,10.1016/j.tiv.2023.105666,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Gossypol synergises antiproliferative effect of sorafenib in metastatic lung cancer cells following Chou-Talalay algorithm.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gossypol synergises antiproliferative effect of sorafenib in metastatic lung cancer cells following Chou-Talalay algorithm.
15058,44227,37572211,10.1007/s11033-023-08672-2,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aflatoxin B1 affects porcine alveolar macrophage growth through the calcium signaling pathway mediated by the ceRNA regulatory network.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aflatoxin B1 affects porcine alveolar macrophage growth through the calcium signaling pathway mediated by the ceRNA regulatory network.
15068,44237,37524230,10.1016/j.jhep.2023.07.026,toxicity,siRNA,PubMed abstract sentence 2,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: First-in-human randomized study of RNAi therapeutic RG6346 for chronic hepatitis B virus infection.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,First-in-human randomized study of RNAi therapeutic RG6346 for chronic hepatitis B virus infection.
15071,44240,37507429,10.1038/s41598-023-39541-4,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues.
15073,44242,37486464,10.1007/s40256-023-00594-5,toxicity,ASO,PubMed abstract sentence 1,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Established and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Established and Emerging Lipid-Lowering Drugs for Primary and Secondary Cardiovascular Prevention.
15079,44248,37464094,10.1038/s12276-023-01044-7,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model.
15080,44249,37463538,10.1016/j.foodchem.2023.136857,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A novel electrochemical aptasensor based on core-shell nanomaterial labeling for simultaneous detection of acetamiprid and malathion.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A novel electrochemical aptasensor based on core-shell nanomaterial labeling for simultaneous detection of acetamiprid and malathion.
15082,44251,37458103,10.1039/d3dt01836a,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cobalt bis(dicarbollide) is a DNA-neutral pharmacophore.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cobalt bis(dicarbollide) is a DNA-neutral pharmacophore.
15105,44274,38019311,10.1007/s00401-023-02652-3,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: G 2 C 4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,G(2)C(4) targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons.
15106,44275,37998809,10.3390/antibiotics12111607,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting FMN, TPP, SAM-I, and glmS Riboswitches with Chimeric Antisense Oligonucleotides for Completely Rational Antibacterial Drug Development.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Targeting FMN, TPP, SAM-I, and glmS Riboswitches with Chimeric Antisense Oligonucleotides for Completely Rational Antibacterial Drug Development."
15107,44276,37704069,10.1016/j.bone.2023.116898,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antisense oligonucleotides targeting a NOTCH3 mutation in male mice ameliorate the cortical osteopenia of lateral meningocele syndrome.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense oligonucleotides targeting a NOTCH3 mutation in male mice ameliorate the cortical osteopenia of lateral meningocele syndrome.
15108,44277,37376093,10.3390/pharmaceutics15061645,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synthesis, Biophysical Properties, and Antitumor Activity of Antisense Oligonucleotides Conjugated with Anisamide.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Synthesis, Biophysical Properties, and Antitumor Activity of Antisense Oligonucleotides Conjugated with Anisamide."
15111,44280,36859811,10.4062/biomolther.2023.001,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Drug Discovery Perspectives of Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Drug Discovery Perspectives of Antisense Oligonucleotides.
15112,44281,36817728,10.1016/j.omtn.2023.01.006,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.
15113,44282,36814640,10.3389/fmolb.2023.1096286,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide.
15123,44292,29620999,10.1089/nat.2018.0720,toxicity,ASO,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Dose-Dependent Lowering of Mutant Huntingtin Using Antisense Oligonucleotides in Huntington Disease Patients.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dose-Dependent Lowering of Mutant Huntingtin Using Antisense Oligonucleotides in Huntington Disease Patients.
15137,44306,33519276,10.1016/j.sjbs.2020.11.066,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In silico prediction and experimental validation of siRNAs targeting ORF1ab of MERS-CoV in Vero cell line.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In silico prediction and experimental validation of siRNAs targeting ORF1ab of MERS-CoV in Vero cell line.
15140,44309,32143590,10.1186/s12886-020-01348-6,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism.
15150,44319,40886138,10.1021/acs.jmedchem.5c00704,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A Novel PROTAC G9a/GLP Degrader that Inhibits, Similar to G9a siRNA, the Migration of MCF-7 Breast-Cancer Cells without Affecting Proliferation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"A Novel PROTAC G9a/GLP Degrader that Inhibits, Similar to G9a siRNA, the Migration of MCF-7 Breast-Cancer Cells without Affecting Proliferation."
15151,44320,40467928,10.1007/s12672-025-02844-1,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Reduced Cish expression by siRNA knockdown in Natural Killer cells promotes anti-tumor effects against gastric cancer cell lines.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Reduced Cish expression by siRNA knockdown in Natural Killer cells promotes anti-tumor effects against gastric cancer cell lines.
15152,44321,40407123,10.1111/eci.70079,toxicity,siRNA,PubMed abstract sentence 7,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: siRNA-based therapeutics for lipoprotein (a) lowering: A path toward precision cardiovascular medicine.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA-based therapeutics for lipoprotein (a) lowering: A path toward precision cardiovascular medicine.
15160,44329,40110301,10.1097/MS9.0000000000002696,toxicity,siRNA,PubMed abstract sentence 9,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Advancing hypertension management: the role of zilebesiran as an siRNA therapeutic agent.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advancing hypertension management: the role of zilebesiran as an siRNA therapeutic agent.
15171,44340,39835559,10.2174/0115665232337735250101121115,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: siRNA Knocking Down in HepG2 Cells Identifies PFKFB4 and HNF4α as Key Genes Important for Cancer Cell Survival.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,siRNA Knocking Down in HepG2 Cells Identifies PFKFB4 and HNF4α as Key Genes Important for Cancer Cell Survival.
15178,44347,39630486,10.1039/d4tb01547a,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Topical siRNA therapy of diabetic-like wound healing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Topical siRNA therapy of diabetic-like wound healing.
15190,44359,39553720,10.7717/peerj.18214,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Investigation of the efficacy of siRNA-mediated KRAS gene silencing in pancreatic cancer therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Investigation of the efficacy of siRNA-mediated KRAS gene silencing in pancreatic cancer therapy.
15192,44361,39539970,10.2147/IJN.S483252,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Stimuli-Responsive Peptide/siRNA Nanoparticles as a Radiation Sensitizer for Glioblastoma Treatment by Co-Inhibiting RELA/P65 and EGFR.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Stimuli-Responsive Peptide/siRNA Nanoparticles as a Radiation Sensitizer for Glioblastoma Treatment by Co-Inhibiting RELA/P65 and EGFR.
15193,44362,39490472,10.1016/j.ijbiomac.2024.136964,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chitosan/siRNA nanoparticles targeting PARP-1 attenuate Neuroinflammation and apoptosis in hyperglycemia-induced oxidative stress in Neuro2a cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chitosan/siRNA nanoparticles targeting PARP-1 attenuate Neuroinflammation and apoptosis in hyperglycemia-induced oxidative stress in Neuro2a cells.
15197,44366,39431993,10.1021/acs.bioconjchem.4c00255,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: A pH-Sensitive cRGD-PEG-siRNA Conjugated Compound Targeting Glioblastoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A pH-Sensitive cRGD-PEG-siRNA Conjugated Compound Targeting Glioblastoma.
15211,44380,39141571,10.1080/17425247.2024.2393244,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: An investigation of nano- and micron-sized carriers based on calcium carbonate and polylactic acid for oral administration of siRNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An investigation of nano- and micron-sized carriers based on calcium carbonate and polylactic acid for oral administration of siRNA.
15212,44381,39127751,10.1038/s41467-024-50600-w,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Conditional RNA interference in mammalian cells via RNA transactivation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Conditional RNA interference in mammalian cells via RNA transactivation.
15219,44388,39057271,10.3390/insects15070539,toxicity,siRNA,PubMed abstract sentence 1,toxic;adverse,"toxicity candidate; matched derived terms: toxic, adverse; source title: Beekeepers Support the Use of RNA Interference (RNAi) to Control Varroa destructor .",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Beekeepers Support the Use of RNA Interference (RNAi) to Control Varroa destructor.
15220,44389,39006767,10.1039/d4ra01965b,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Carboxymethylcellulose encapsulated fingolimod, siRNA@ZnO hybrid nanocomposite as a new anti-Alzheimer's material.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Carboxymethylcellulose encapsulated fingolimod, siRNA@ZnO hybrid nanocomposite as a new anti-Alzheimer's material."
15237,44406,34089909,10.1016/j.meegid.2021.104951,offtarget,siRNA,PubMed abstract sentence 7,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2.
15238,44407,33786418,10.1002/acg2.107,offtarget,siRNA,PubMed abstract sentence 5,off-target;seed;mismatch,"offtarget candidate; matched derived terms: off-target, seed, mismatch; source title: An in silico analysis of effective siRNAs against COVID-19 by targeting the leader sequence of SARS-CoV-2.",B,high_candidate,curator_rejected,reject,derived_annotations_only,An in silico analysis of effective siRNAs against COVID-19 by targeting the leader sequence of SARS-CoV-2.
15239,44408,33664996,10.1016/j.omtn.2021.01.018,offtarget,siRNA,PubMed abstract sentence 1,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity.
15242,44411,32749923,10.1089/nat.2020.0857,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Modulating Polymer-siRNA Binding Does Not Promote Polyplex-Mediated Silencing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Modulating Polymer-siRNA Binding Does Not Promote Polyplex-Mediated Silencing.
15246,44415,32857010,10.1089/nat.2020.0878,toxicity,ASO,PubMed abstract sentence 5,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: Strategies for Identity Testing of Therapeutic Oligonucleotide Drug Substances and Drug Products.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Strategies for Identity Testing of Therapeutic Oligonucleotide Drug Substances and Drug Products.
15255,44424,32175808,10.1089/nat.2020.0848,offtarget,siRNA,PubMed abstract sentence 6,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells.
15265,44434,30817230,10.1089/nat.2018.0754,toxicity,ASO,PubMed abstract sentence 5,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: IONIS-PKK Rx a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,IONIS-PKK(Rx) a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production.
15284,44453,28727419,10.1021/acsnano.7b04734,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Next-Generation Lipids in RNA Interference Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Next-Generation Lipids in RNA Interference Therapeutics.
15286,44455,28694238,10.1016/j.actbio.2017.07.014,toxicity,siRNA,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Functionalized bioengineered spider silk spheres improve nuclease resistance and activity of oligonucleotide therapeutics providing a strategy for cancer treatment.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Functionalized bioengineered spider silk spheres improve nuclease resistance and activity of oligonucleotide therapeutics providing a strategy for cancer treatment.
15288,44457,28610721,10.1016/j.bbamem.2017.06.006,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cationic liposomal vectors incorporating a bolaamphiphile for oligonucleotide antimicrobials.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cationic liposomal vectors incorporating a bolaamphiphile for oligonucleotide antimicrobials.
15296,44465,27570789,10.14304/surya.jpr.v4n7.5,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNA therapeutics: RNAi and antisense mechanisms and clinical applications.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RNA therapeutics: RNAi and antisense mechanisms and clinical applications.
15297,44466,27483025,10.1038/mtna.2016.55,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.
15299,44468,27420413,10.1021/jacs.6b05787,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Effective Antisense Gene Regulation via Noncationic, Polyethylene Glycol Brushes.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Effective Antisense Gene Regulation via Noncationic, Polyethylene Glycol Brushes."
15302,44471,26623938,10.1038/mtna.2015.38,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain.
15325,44494,41780910,10.1093/eurheartj/ehag147,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Breast tumour-secreted ADAM10 mediates atrial fibrogenesis and fibrillation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Breast tumour-secreted ADAM10 mediates atrial fibrogenesis and fibrillation.
15337,44506,41752118,10.3390/ijms27041978,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review.
15357,44526,41724477,10.3168/jds.2025-27574,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The E3 ubiquitin ligase NEDD4 protects against nonesterified fatty acid-induced hepatic inflammatory injury in ketotic cows.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The E3 ubiquitin ligase NEDD4 protects against nonesterified fatty acid-induced hepatic inflammatory injury in ketotic cows.
15373,44542,41419139,10.1016/j.ejps.2025.107417,toxicity,ASO/siRNA,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ASIC3-PLCG1 axis-driven macropinocytosis promotes osimertinib drug-tolerant persistence in malignant pleural effusion-associated NSCLC.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,ASIC3-PLCG1 axis-driven macropinocytosis promotes osimertinib drug-tolerant persistence in malignant pleural effusion-associated NSCLC.
15376,44545,41398390,10.1038/s41416-025-03292-y,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Targeting Bcl-xL to eliminate chemotherapy-induced tumor dormancy and prevent breast cancer metastasis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting Bcl-xL to eliminate chemotherapy-induced tumor dormancy and prevent breast cancer metastasis.
15384,44553,41275931,10.1016/j.freeradbiomed.2025.11.047,toxicity,siRNA,PubMed abstract sentence 1,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Activation of RXRα mitigates maternal separation-induced hippocampal neurodevelopmental impairment in mice by inhibiting oxidative stress and restoring mitochondrial homeostasis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Activation of RXRα mitigates maternal separation-induced hippocampal neurodevelopmental impairment in mice by inhibiting oxidative stress and restoring mitochondrial homeostasis.
15387,44556,40865887,10.1016/j.tiv.2025.106133,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hyperuricemia impairs endothelial function through SMS2-dependent activation of the endoplasmic reticulum stress response.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hyperuricemia impairs endothelial function through SMS2-dependent activation of the endoplasmic reticulum stress response.
15396,44565,41378010,10.21037/tcr-2025-1284,toxicity,ASO/siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ING5-mediated regulation of lung cancer progression via the OIP5-AS1/miR-381-3p/SEC24A axis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,ING5-mediated regulation of lung cancer progression via the OIP5-AS1/miR-381-3p/SEC24A axis.
15408,44577,41258063,10.20892/j.issn.2095-3941.2025.0275,toxicity,ASO/siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nintedanib enhances tumor cell radiosensitivity by promoting ferroptosis and modulating the ATF4/SLC7A11/GSH axis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nintedanib enhances tumor cell radiosensitivity by promoting ferroptosis and modulating the ATF4/SLC7A11/GSH axis.
15412,44581,41234867,10.21037/tcr-2025-938,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: shRNA-based PD-1 suppression preserves memory phenotype and function of CD19-targeted CAR-T cell.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,shRNA-based PD-1 suppression preserves memory phenotype and function of CD19-targeted CAR-T cell.
15414,44583,41233896,10.1186/s13045-025-01730-1,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Directly reprogrammed NK cells driven by BCL11B depletion enhance targeted immunotherapy against pancreatic ductal adenocarcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Directly reprogrammed NK cells driven by BCL11B depletion enhance targeted immunotherapy against pancreatic ductal adenocarcinoma.
15415,44584,41220403,10.2147/JIR.S532042,toxicity,ASO,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells.
15419,44588,41072709,10.1016/j.envpol.2025.127231,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Increased S-adenosyl methionine strengthens the suppression in mitochondrial unfolded protein response induced by 6-PPD quinone at environmentally relevant concentrations in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Increased S-adenosyl methionine strengthens the suppression in mitochondrial unfolded protein response induced by 6-PPD quinone at environmentally relevant concentrations in Caenorhabditis elegans.
15444,44613,40403679,10.1016/j.bbrc.2025.152046,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Senkyunolide A mitigates lipid deposition in hyperlipidemic hepatocytes through SIRT6-mediated suppression of oxidative stress and fetuin-A.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Senkyunolide A mitigates lipid deposition in hyperlipidemic hepatocytes through SIRT6-mediated suppression of oxidative stress and fetuin-A.
15449,44618,40394046,10.1038/s41467-025-60039-2,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases.
15453,44622,40361284,10.1080/13510002.2025.2503130,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Kaempferol protects against doxorubicin-induced myocardial damage by inhibiting mitochondrial ROS-dependent ferroptosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Kaempferol protects against doxorubicin-induced myocardial damage by inhibiting mitochondrial ROS-dependent ferroptosis.
15459,44628,40337514,10.3389/fphar.2025.1557681,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
15465,44634,40331953,10.3390/ijms26083491,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: High Mobility Group Box 1 Is Potential Target Therapy for Inhibiting Metastasis and Enhancing Drug Sensitivity of Hepatocellular Carcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,High Mobility Group Box 1 Is Potential Target Therapy for Inhibiting Metastasis and Enhancing Drug Sensitivity of Hepatocellular Carcinoma.
15475,44644,40256236,10.34172/bi.30424,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting hypoxia-inducible factor 1 alpha augments synergistic effects of chemo/immunotherapy via modulating tumor microenvironment in a breast cancer mouse model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting hypoxia-inducible factor 1 alpha augments synergistic effects of chemo/immunotherapy via modulating tumor microenvironment in a breast cancer mouse model.
15476,44645,40254195,10.1016/j.ijbiomac.2025.143282,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanostructured aptasensors for ricin detection and tumor therapy: exploring aptamer-protein interactions and conformational stability in biological complexities.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanostructured aptasensors for ricin detection and tumor therapy: exploring aptamer-protein interactions and conformational stability in biological complexities.
15492,44661,40189060,10.1016/j.neuro.2025.04.003,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PRDX1 affects acrylamide-induced neural damage through the PTEN/AKT signaling pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PRDX1 affects acrylamide-induced neural damage through the PTEN/AKT signaling pathway.
15497,44666,40171277,10.1016/j.omtn.2025.102496,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,CAG-targeted brain-permeable therapy tested in biallelic humanized polyQ mouse models.
15504,44673,40146901,10.1021/acs.inorgchem.4c05359,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Luminescent Iridium-Peptide Nucleic Acid Bioconjugate as Photosensitizer for Singlet Oxygen Production toward a Potential Dual Therapeutic Agent.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Luminescent Iridium-Peptide Nucleic Acid Bioconjugate as Photosensitizer for Singlet Oxygen Production toward a Potential Dual Therapeutic Agent.
15518,44687,40096771,10.1016/j.neo.2025.101152,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma.
15528,44697,40060290,10.1007/s13205-025-04249-x,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Triple regulation of oxidative-acetylation cycling pathways in COPD glucocorticoid resistance by HuaTanJiangQi capsules.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Triple regulation of oxidative-acetylation cycling pathways in COPD glucocorticoid resistance by HuaTanJiangQi capsules.
15531,44700,40043964,10.1016/j.ijpharm.2025.125424,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exploring the promise of lipoplexes: From concept to clinical applications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exploring the promise of lipoplexes: From concept to clinical applications.
15538,44707,40015535,10.1016/j.jep.2025.119550,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Effect of Sceptridium ternatum extract (STE) on radiation-induced pulmonary fibrosis by inhibiting cell adhesion factor CEACAM1.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Effect of Sceptridium ternatum extract (STE) on radiation-induced pulmonary fibrosis by inhibiting cell adhesion factor CEACAM1.
15539,44708,40012358,10.1021/acs.jmedchem.4c02819,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Discovery of Novel Oxazolo[4,3- f ]purine Derivatives as Antitumor Agents through PPIA Interaction.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction."
15557,44726,39958321,10.2147/IJN.S495399,toxicity,ASO/siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells.
15562,44731,39947390,10.1016/j.neuropharm.2025.110362,toxicity,siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Esketamine mitigates endotoxin-induced hippocampal injury by regulating calcium transient and synaptic plasticity via the NF-α1/CREB pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Esketamine mitigates endotoxin-induced hippocampal injury by regulating calcium transient and synaptic plasticity via the NF-α1/CREB pathway.
15569,44738,39914624,10.1016/j.taap.2025.117261,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Inhibition of GRK2 reduced doxorubicin-induced oxidative stress and apoptosis through upregulating ADH1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of GRK2 reduced doxorubicin-induced oxidative stress and apoptosis through upregulating ADH1.
15575,44744,39880501,10.1016/j.aca.2025.343662,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Multiple gRNAs-assisted CRISPR/Cas12a-based portable aptasensor enabling glucometer readout for amplification-free and quantitative detection of malathion.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Multiple gRNAs-assisted CRISPR/Cas12a-based portable aptasensor enabling glucometer readout for amplification-free and quantitative detection of malathion.
15580,44749,39863313,10.1016/j.aca.2025.343665,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Ratiometric fluorescent aptasensor based on DNA-gated Fe 3 O 4 @Uio-66-NH 2 and Exo I-assisted signal amplification.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ratiometric fluorescent aptasensor based on DNA-gated Fe(3)O(4)@Uio-66-NH(2) and Exo I-assisted signal amplification.
15585,44754,39844419,10.2174/0113862073354456241219065512,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Resveratrol Reduces Cisplatin-induced Cochlear Hair Cell Pyroptosis by Inhibiting the mtROS/TXNIP/NLRP3 Pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Resveratrol Reduces Cisplatin-induced Cochlear Hair Cell Pyroptosis by Inhibiting the mtROS/TXNIP/NLRP3 Pathway.
15591,44760,39820726,10.1007/s10555-025-10243-9,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advancements in gene therapies targeting mutant KRAS in cancers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advancements in gene therapies targeting mutant KRAS in cancers.
15594,44763,39814318,10.1016/j.neuint.2025.105936,toxicity,ASO/siRNA,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of Kv1.1 channels ameliorates Cu(II)-induced microglial activation and cognitive impairment in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of Kv1.1 channels ameliorates Cu(II)-induced microglial activation and cognitive impairment in mice.
15599,44768,39783918,10.1021/acs.analchem.4c03437,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Folding an RCA Scaffold into an Intelligent Coiled Nanosnake for Precise/Synergistic RNAi-/Chemotherapy of Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Folding an RCA Scaffold into an Intelligent Coiled Nanosnake for Precise/Synergistic RNAi-/Chemotherapy of Cancer.
15603,44772,39746602,10.1016/j.lfs.2024.123358,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MCP-enhanced SOD3 activity inhibits gastric cancer and potentiate chemotherapy via modulating EGFR signaling.",B,high_candidate,curator_rejected,reject,derived_annotations_only,MCP-enhanced SOD3 activity inhibits gastric cancer and potentiate chemotherapy via modulating EGFR signaling.
15605,44774,39744222,10.7150/thno.99588,toxicity,ASO/siRNA,PubMed abstract sentence 12,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma.
15611,44780,39700772,10.1016/j.ecoenv.2024.117546,toxicity,siRNA,PubMed abstract sentence 1,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway.
15612,44781,39688855,10.1093/g3journal/jkae297,toxicity,ASO,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Automated plasmid design for marker-free genome editing in budding yeast.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Automated plasmid design for marker-free genome editing in budding yeast.
15613,44782,39671784,10.1016/j.phymed.2024.156312,toxicity,ASO/siRNA,PubMed abstract sentence 20,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Sesquiterpene lactone from Artemisia argyi inhibited cancer proliferation by inducing apoptosis and ferroptosis via key cell metabolism enzyme NDUFA4.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sesquiterpene lactone from Artemisia argyi inhibited cancer proliferation by inducing apoptosis and ferroptosis via key cell metabolism enzyme NDUFA4.
15616,44785,39638470,10.1016/j.aca.2024.343426,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Construction of label-free electrochemical aptasensor and logic circuit based on triple-stranded DNA molecular switch.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Construction of label-free electrochemical aptasensor and logic circuit based on triple-stranded DNA molecular switch.
15620,44789,39575476,10.1002/smll.202408095,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineering Nano-Pills to Inhibit Ovarian Cancer Proliferation and Migration through a Combination of Chemical/Nucleic Acid Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineering Nano-Pills to Inhibit Ovarian Cancer Proliferation and Migration through a Combination of Chemical/Nucleic Acid Therapy.
15623,44792,39514961,10.1016/j.neo.2024.101078,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context.
15624,44793,39460406,10.1002/adhm.202403539,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aptamer-Encapsulated Cellular Nanoparticles for Neurotoxin Neutralization.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aptamer-Encapsulated Cellular Nanoparticles for Neurotoxin Neutralization.
15625,44794,39446217,10.1007/s12035-024-04543-4,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer's Pathogenesis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer's Pathogenesis.
15626,44795,39401270,10.1002/mabi.202400327,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cationic Carbosilane Dendrimers for Apmnkq2 Aptamer Transfection in Breast Cancer: An Alternative to Traditional Transfectants.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cationic Carbosilane Dendrimers for Apmnkq2 Aptamer Transfection in Breast Cancer: An Alternative to Traditional Transfectants.
15641,44810,39776903,10.3389/fimmu.2024.1519415,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Soluble factors released by peripheral blood-derived CAR-NK cells cause bystander myeloid cell activation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Soluble factors released by peripheral blood-derived CAR-NK cells cause bystander myeloid cell activation.
15642,44811,39769049,10.3390/ijms252413283,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cadmium-Induced Oxidative Damage and the Expression and Function of Mitochondrial Thioredoxin in Phascolosoma esculenta .",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cadmium-Induced Oxidative Damage and the Expression and Function of Mitochondrial Thioredoxin in Phascolosoma esculenta.
15643,44812,39741316,10.1186/s13020-024-01034-5,toxicity,siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis.
15649,44818,39632972,10.1038/s41598-024-81800-5,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of a controlled-release mosquito RNAi yeast larvicide suitable for the sustained control of large water storage containers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of a controlled-release mosquito RNAi yeast larvicide suitable for the sustained control of large water storage containers.
15650,44819,39629104,10.2147/IJN.S487598,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene Silencing.
15654,44823,39588262,10.2147/IJN.S481368,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Artificially Modified NK Cell-Based Synergistic Immuno-Gene-Photodynamic Therapy for Cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Artificially Modified NK Cell-Based Synergistic Immuno-Gene-Photodynamic Therapy for Cancer.
15658,44827,39547060,10.1016/j.ecoenv.2024.117331,toxicity,siRNA,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MANF inhibits NLRP3 inflammasome activation by competitively binding to DDX3X in paraquat-stimulated alveolar macrophages.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,MANF inhibits NLRP3 inflammasome activation by competitively binding to DDX3X in paraquat-stimulated alveolar macrophages.
15662,44831,39477601,10.1016/j.pestbp.2024.106148,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Molecular characterization and functional analysis of genes mediating emamectin benzoate action to the pinewood nematode (Bursaphelenchus xylophilus).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Molecular characterization and functional analysis of genes mediating emamectin benzoate action to the pinewood nematode (Bursaphelenchus xylophilus).
15664,44833,39452993,10.3390/nano14201657,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted PHA Microsphere-Loaded Triple-Drug System with Sustained Drug Release for Synergistic Chemotherapy and Gene Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeted PHA Microsphere-Loaded Triple-Drug System with Sustained Drug Release for Synergistic Chemotherapy and Gene Therapy.
15673,44842,39369270,10.1016/j.ymthe.2024.09.034,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineered extracellular vesicles for combinatorial TNBC therapy: SR-SIM-guided design achieves substantial drug dosage reduction.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Engineered extracellular vesicles for combinatorial TNBC therapy: SR-SIM-guided design achieves substantial drug dosage reduction.
15677,44846,39339274,10.3390/pharmaceutics16091238,toxicity,siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cyclin-Dependent Kinase 8 Represents a Positive Regulator of Cytomegalovirus Replication and a Novel Host Target for Antiviral Strategies.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cyclin-Dependent Kinase 8 Represents a Positive Regulator of Cytomegalovirus Replication and a Novel Host Target for Antiviral Strategies.
15679,44848,39332459,10.1016/j.ijpharm.2024.124757,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Temperature switchable linkers suitable for triggered drug release in cancer thermo-chemotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Temperature switchable linkers suitable for triggered drug release in cancer thermo-chemotherapy.
15681,44850,39313182,10.1016/j.cbpa.2024.111749,toxicity,ASO/siRNA,PubMed abstract sentence 14,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Characterization and functional analysis of Litopenaeus vannamei Na + /K + /2Cl - cotransporter 1 under nitrite stress.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Characterization and functional analysis of Litopenaeus vannamei Na(+)/K(+)/2Cl(-) cotransporter 1 under nitrite stress.
15687,44856,39269209,10.1002/chem.202402787,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Selective Interaction of Chiral Carbon Dots with Nucleic Acids: A Promising Nanosensing Platform.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Selective Interaction of Chiral Carbon Dots with Nucleic Acids: A Promising Nanosensing Platform.
15691,44860,39241994,10.1016/j.ijbiomac.2024.135323,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Chitosan nanoparticles encapsulated Piper betle essential oil alleviates Alzheimer's disease associated pathology in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Chitosan nanoparticles encapsulated Piper betle essential oil alleviates Alzheimer's disease associated pathology in Caenorhabditis elegans.
15693,44862,39218082,10.1016/j.scitotenv.2024.175903,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: Transgenerational response of germline histone acetyltransferases and deacetylases to nanoplastics at predicted environmental doses in Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transgenerational response of germline histone acetyltransferases and deacetylases to nanoplastics at predicted environmental doses in Caenorhabditis elegans.
15698,44867,39180089,10.1186/s13104-024-06900-x,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhibition of GPR68 kills glioblastoma in zebrafish xenograft models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of GPR68 kills glioblastoma in zebrafish xenograft models.
15712,44881,39048201,10.1016/j.carbpol.2024.122407,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The application of marine polysaccharides to antitumor nanocarriers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The application of marine polysaccharides to antitumor nanocarriers.
15714,44883,38994035,10.7150/thno.95423,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Osteoblast-specific down-regulation of NLRP3 inflammasome by aptamer-functionalized liposome nanoparticles improves bone quality in postmenopausal osteoporosis rats.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Osteoblast-specific down-regulation of NLRP3 inflammasome by aptamer-functionalized liposome nanoparticles improves bone quality in postmenopausal osteoporosis rats.
15718,44887,38961849,10.1002/jgm.3716,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Biocompatible hydroxyapatite-based nano vehicle bypasses viral transduction and enables sustained silencing of a pluripotency marker gene, demonstrating desired differentiation in mouse embryonic stem cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Biocompatible hydroxyapatite-based nano vehicle bypasses viral transduction and enables sustained silencing of a pluripotency marker gene, demonstrating desired differentiation in mouse embryonic stem cells."
15719,44888,38922100,10.3390/toxics12060420,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans .",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans.
15724,44893,37804762,10.1016/j.jhazmat.2023.132597,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: 1,2-bis(2,4,6-tribromophenoxy) ethane, a novel brominated flame retardant, disrupts intestinal barrier function via the IRX3/NOS2 axis in rat small intestine.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"1,2-bis(2,4,6-tribromophenoxy) ethane, a novel brominated flame retardant, disrupts intestinal barrier function via the IRX3/NOS2 axis in rat small intestine."
15725,44894,37797755,10.1016/j.scitotenv.2023.167538,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Investigation into the electrochemical advanced oxidation of p-arsanilic acid: Peculiar role of electrolytes and unexpected formation of coupling byproducts.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Investigation into the electrochemical advanced oxidation of p-arsanilic acid: Peculiar role of electrolytes and unexpected formation of coupling byproducts.
15731,44900,37883094,10.1167/iovs.64.13.41,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Proteopathy Linked to Exon-Skipping Isoform of RGR-Opsin Contributes to the Pathogenesis of Age-Related Macular Degeneration.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Proteopathy Linked to Exon-Skipping Isoform of RGR-Opsin Contributes to the Pathogenesis of Age-Related Macular Degeneration.
15740,44909,37719367,10.1016/j.apsb.2023.03.020,toxicity,siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antitumor synergism between PAK4 silencing and immunogenic phototherapy of engineered extracellular vesicles.
15743,44912,37692001,10.4103/JAPTR.JAPTR_117_23,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Preventive treatment of coronavirus disease-2019 virus using coronavirus disease-2019-receptor-binding domain 1C aptamer by suppress the expression of angiotensin-converting enzyme 2 receptor.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preventive treatment of coronavirus disease-2019 virus using coronavirus disease-2019-receptor-binding domain 1C aptamer by suppress the expression of angiotensin-converting enzyme 2 receptor.
15746,44915,37668953,10.1007/s11883-023-01141-y,toxicity,siRNA,PubMed abstract sentence 10,safety;risk;tolerability,"toxicity candidate; matched derived terms: safety, risk, tolerability; source title: Treatment of Lp(a): Is It the Future or Are We Ready Today?",B,high_candidate,curator_rejected,reject,derived_annotations_only,Treatment of Lp(a): Is It the Future or Are We Ready Today?
15749,44918,37635089,10.1002/chem.202301928,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Post-Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex-Forming Ability.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Post-Synthetic Nucleobase Modification of Oligodeoxynucleotides by Sonogashira Coupling and Influence of Alkynyl Modifications on the Duplex-Forming Ability.
15751,44920,37624247,10.3390/toxins15080490,toxicity,ASO,PubMed abstract sentence 13,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In Silico-Ex Vitro Iteration Strategy for Affinity Maturation of Anti-Ricin Peptides and the SPR Biosensing Application.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In Silico-Ex Vitro Iteration Strategy for Affinity Maturation of Anti-Ricin Peptides and the SPR Biosensing Application.
15752,44921,37562474,10.1016/j.ijbiomac.2023.126245,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Thermodynamic and cellular studies of doxorubicin/daunorubicin loaded by a DNA tetrahedron for diagnostic imaging, chemotherapy, and gene therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Thermodynamic and cellular studies of doxorubicin/daunorubicin loaded by a DNA tetrahedron for diagnostic imaging, chemotherapy, and gene therapy."
15753,44922,37557998,10.1016/j.chemosphere.2023.139751,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Immobilizing arsenic-enriched wastewater from utilization of crude antimony oxides as scorodite using a novel multivalent iron source.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Immobilizing arsenic-enriched wastewater from utilization of crude antimony oxides as scorodite using a novel multivalent iron source.
15754,44923,37515225,10.3390/v15071539,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Analogs of the Catechol Derivative Dynasore Inhibit HIV-1 Ribonuclease H, SARS-CoV-2 nsp14 Exoribonuclease, and Virus Replication."
15761,44930,37424909,10.3389/fcvm.2023.1181720,toxicity,ASO/siRNA,PubMed abstract sentence 7,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Painful and recurring injection site reaction to alirocumab and evolocumab in a young woman with familial hypercholesterolemia and effective therapeutic alternative based on inclisiran: a case report.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Painful and recurring injection site reaction to alirocumab and evolocumab in a young woman with familial hypercholesterolemia and effective therapeutic alternative based on inclisiran: a case report.
15763,44932,37421887,10.1016/j.ejmech.2023.115611,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: 2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1."
15777,44946,42225274,10.1080/0886022X.2026.2670055,toxicity,ASO,PubMed abstract sentence 9,risk;renal,"toxicity candidate; matched derived terms: risk, renal; source title: tRF-1-ArgTCG-1-1 promotes renal fibrosis by regulating β-catenin.",B,high_candidate,curator_rejected,reject,derived_annotations_only,tRF-1-ArgTCG-1-1 promotes renal fibrosis by regulating β-catenin.
15781,44950,42226100,10.1186/s11658-026-00952-6,toxicity,siRNA,PubMed abstract sentence 15,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Exendin-4 averts all-trans-retinal-driven damage to photoreceptors and the retina via the GLP-1R/PKA/CREB1 signaling axis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Exendin-4 averts all-trans-retinal-driven damage to photoreceptors and the retina via the GLP-1R/PKA/CREB1 signaling axis.
15788,44957,37373287,10.3390/ijms241210139,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Less Severe Lipopolysaccharide-Induced Inflammation in Conditional mgmt -Deleted Mice with LysM-Cre System: The Loss of DNA Repair in Macrophages.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Less Severe Lipopolysaccharide-Induced Inflammation in Conditional mgmt-Deleted Mice with LysM-Cre System: The Loss of DNA Repair in Macrophages.
15792,44961,37365539,10.1186/s12864-023-09470-7,offtarget,siRNA,PubMed abstract sentence 15,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Long-wave opsin involved in body color plastic development in Nilaparvata lugens.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Long-wave opsin involved in body color plastic development in Nilaparvata lugens.
15795,44964,37349699,10.1186/s12864-023-09459-2,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: PagMYB151 facilitates proline accumulation to enhance salt tolerance of poplar.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PagMYB151 facilitates proline accumulation to enhance salt tolerance of poplar.
15798,44967,37341540,10.1021/acsami.3c05443,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Mesoporous Polydopamine-Encapsulated Fluorescent Nanodiamonds: A Versatile Platform for Biomedical Applications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mesoporous Polydopamine-Encapsulated Fluorescent Nanodiamonds: A Versatile Platform for Biomedical Applications.
15801,44970,37294468,10.1007/s11033-023-08539-6,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Epigenomics in stress tolerance of plants under the climate change.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Epigenomics in stress tolerance of plants under the climate change.
15802,44971,37284446,10.7150/thno.81406,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure.
15812,44981,37242702,10.3390/pharmaceutics15051451,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Evaluation of Poly( N -Ethyl Pyrrolidine Methacrylamide) (EPA) and Derivatives as Polymeric Vehicles for miRNA Delivery to Neural Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluation of Poly(N-Ethyl Pyrrolidine Methacrylamide) (EPA) and Derivatives as Polymeric Vehicles for miRNA Delivery to Neural Cells.
15821,44990,37203277,10.1002/advs.202207118,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Remodeling Serine Synthesis and Metabolism via Nanoparticles (NPs)-Mediated CFL1 Silencing to Enhance the Sensitivity of Hepatocellular Carcinoma to Sorafenib.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Remodeling Serine Synthesis and Metabolism via Nanoparticles (NPs)-Mediated CFL1 Silencing to Enhance the Sensitivity of Hepatocellular Carcinoma to Sorafenib.
15822,44991,37201874,10.1016/j.bcp.2023.115608,toxicity,siRNA,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeted and functional genomics approaches to the mechanism of action of lagunamide D, a mitochondrial cytotoxin from marine cyanobacteria.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Targeted and functional genomics approaches to the mechanism of action of lagunamide D, a mitochondrial cytotoxin from marine cyanobacteria."
15829,44998,37147890,10.1111/cts.13531,toxicity,ASO/siRNA,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: A single ascending dose study of single-stranded oligodeoxyribonucleotide RO7062931 in Chinese healthy volunteers.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A single ascending dose study of single-stranded oligodeoxyribonucleotide RO7062931 in Chinese healthy volunteers.
15837,45006,37096555,10.1080/14728214.2023.2205639,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Emerging drugs for hepatitis D.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Emerging drugs for hepatitis D.
15841,45010,37078062,10.1016/j.omtn.2023.03.011,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Self-transfecting GMO-PMO chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Self-transfecting GMO-PMO chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse.
15843,45012,37066790,10.1161/CIRCULATIONAHA.122.061940,offtarget,siRNA,PubMed abstract sentence 14,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.
15846,45015,37059380,10.1016/j.fct.2023.113782,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway.
15847,45016,37050317,10.3390/polym15071703,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synthesis of Novel 2,9-Disubstituted-6-morpholino Purine Derivatives Assisted by Virtual Screening and Modelling of Class I PI3K Isoforms.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Synthesis of Novel 2,9-Disubstituted-6-morpholino Purine Derivatives Assisted by Virtual Screening and Modelling of Class I PI3K Isoforms."
15848,45017,37031257,10.1038/s41467-023-37774-5,offtarget,siRNA,PubMed abstract sentence 5,off-target;unintended,"offtarget candidate; matched derived terms: off-target, unintended; source title: RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes.
15849,45018,37030566,10.1016/j.bmcl.2023.129275,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Discovery of novel PROTACs based on multi-targeted angiogenesis inhibitors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Discovery of novel PROTACs based on multi-targeted angiogenesis inhibitors.
15851,45020,37028002,10.1016/j.bios.2023.115282,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Functional DNA sensors integrated with nucleic acid signal amplification strategies for non-nucleic acid targets detection.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Functional DNA sensors integrated with nucleic acid signal amplification strategies for non-nucleic acid targets detection.
15852,45021,37021909,10.1002/prp2.1080,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: The N-Acetylgalactosamine-conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low-density lipoprotein cholesterol reductions.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The N-Acetylgalactosamine-conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low-density lipoprotein cholesterol reductions.
15855,45024,37002654,10.1111/cts.13498,toxicity,ASO,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: A multi-purpose Japanese phase I study in the global development of vupanorsen: Randomized, placebo-controlled, single-ascending dose study in adults.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"A multi-purpose Japanese phase I study in the global development of vupanorsen: Randomized, placebo-controlled, single-ascending dose study in adults."
15861,45030,36963943,10.1016/j.pestbp.2023.105374,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Functional characterization of cytochrome P450s associated with pyrethroid resistance in the olive fruit fly Bactrocera oleae.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Functional characterization of cytochrome P450s associated with pyrethroid resistance in the olive fruit fly Bactrocera oleae.
15862,45031,36963929,10.1016/j.pestbp.2023.105347,offtarget,siRNA,PubMed abstract sentence 10,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: SfDicer1 participates in the regulation of molting development and reproduction in the white-backed planthopper, Sogatella furcifera.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"SfDicer1 participates in the regulation of molting development and reproduction in the white-backed planthopper, Sogatella furcifera."
15864,45033,36963459,10.1016/j.canlet.2023.216141,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Milk/colostrum exosomes: A nanoplatform advancing delivery of cancer therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Milk/colostrum exosomes: A nanoplatform advancing delivery of cancer therapeutics.
15871,45040,36910716,10.1016/j.omtn.2023.02.021,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inhalation of an RNA aptamer that selectively binds extracellular histones protects from acute lung injury.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhalation of an RNA aptamer that selectively binds extracellular histones protects from acute lung injury.
15872,45041,36893927,10.1016/j.fsi.2023.108672,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4/ NF-κB/ p53 pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4/ NF-κB/ p53 pathway.
15878,45047,36834935,10.3390/ijms24043525,toxicity,ASO/siRNA,PubMed abstract sentence 7,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: bioTCIs: Middle-to-Macro Biomolecular Targeted Covalent Inhibitors Possessing Both Semi-Permanent Drug Action and Stringent Target Specificity as Potential Antibody Replacements.",B,high_candidate,curator_rejected,reject,derived_annotations_only,bioTCIs: Middle-to-Macro Biomolecular Targeted Covalent Inhibitors Possessing Both Semi-Permanent Drug Action and Stringent Target Specificity as Potential Antibody Replacements.
15880,45049,36831000,10.3390/biomedicines11020465,toxicity,ASO,PubMed abstract sentence 7,toxic;renal,"toxicity candidate; matched derived terms: toxic, renal; source title: Micro Ribonucleic Acid-29a (miR-29a) Antagonist Normalizes Bone Metabolism in Osteogenesis Imperfecta (OI) Mice Model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Micro Ribonucleic Acid-29a (miR-29a) Antagonist Normalizes Bone Metabolism in Osteogenesis Imperfecta (OI) Mice Model.
15881,45050,36813076,10.1016/j.neulet.2023.137141,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Effect of sevoflurane anesthesia to neonatal rat hippocampus by RNA-seq.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Effect of sevoflurane anesthesia to neonatal rat hippocampus by RNA-seq.
15890,45059,36775865,10.1002/advs.202206893,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Metabolic Modulation of Intracellular Ammonia via Intravesical Instillation of Nanoporter-Encased Hydrogel Eradicates Bladder Carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Metabolic Modulation of Intracellular Ammonia via Intravesical Instillation of Nanoporter-Encased Hydrogel Eradicates Bladder Carcinoma.
15892,45061,36762732,10.1021/acs.jafc.2c08473,toxicity,siRNA,PubMed abstract sentence 4,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: RNAi-Based Biopesticides Against 28-Spotted Ladybeetle Henosepilachna vigintioctopunctata Does Not Harm the Insect Predator Propylea japonica .",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi-Based Biopesticides Against 28-Spotted Ladybeetle Henosepilachna vigintioctopunctata Does Not Harm the Insect Predator Propylea japonica.
15896,45065,36719755,10.1172/jci.insight.160516,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration.
15897,45066,36715900,10.1007/978-1-0716-2970-3_4,offtarget,siRNA,PubMed abstract sentence 2,off-target;unintended,"offtarget candidate; matched derived terms: off-target, unintended; source title: Utilizing the FLP-Out System for Clonal RNAi Analysis in the Adult Drosophila Ovary.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Utilizing the FLP-Out System for Clonal RNAi Analysis in the Adult Drosophila Ovary.
15899,45068,36709649,10.1016/j.ejmech.2023.115148,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance.
15900,45069,36704052,10.1016/j.jhepr.2022.100652,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries.
15904,45073,36678889,10.3390/pharmaceutics15010260,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, adverse; source title: What Can RNA-Based Therapy Do for Monogenic Diseases?",B,high_candidate,curator_rejected,reject,derived_annotations_only,What Can RNA-Based Therapy Do for Monogenic Diseases?
15912,45081,36614194,10.3390/ijms24010752,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Target-Specific Nanoparticle Polyplex Down-Regulates Mutant Kras to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Target-Specific Nanoparticle Polyplex Down-Regulates Mutant Kras to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression.
15913,45082,36608275,10.1021/acs.jmedchem.2c01557,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Inducible Degradation of Oncogenic Nucleolin Using an Aptamer-Based PROTAC.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Inducible Degradation of Oncogenic Nucleolin Using an Aptamer-Based PROTAC.
15918,45087,36576645,10.1007/s10072-022-06568-w,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A case of severe increase of liver enzymes in a ATTRv patient after one year of inotersen treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A case of severe increase of liver enzymes in a ATTRv patient after one year of inotersen treatment.
15921,45090,36527705,10.1002/ps.7326,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bacteria-mediated RNAi for managing fall webworm, Hyphantria cunea: screening target genes and analyzing lethal effect.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Bacteria-mediated RNAi for managing fall webworm, Hyphantria cunea: screening target genes and analyzing lethal effect."
15923,45092,36524395,10.1039/d2tb01179d,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nucleic acid-based artificial nanocarriers for gene therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nucleic acid-based artificial nanocarriers for gene therapy.
15926,45095,36446522,10.26508/lsa.202201801,offtarget,siRNA,PubMed abstract sentence 5,off-target;unintended;silencing,"offtarget candidate; matched derived terms: off-target, unintended, silencing; source title: Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes.
15927,45096,36436570,10.1016/j.exer.2022.109333,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Use of vivo-morpholinos for gene knockdown in the postnatal shark retina.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Use of vivo-morpholinos for gene knockdown in the postnatal shark retina.
15931,45100,36401033,10.1007/978-1-0716-2772-3_13,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Peptide-Conjugated PMOs for the Treatment of Myotonic Dystrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Peptide-Conjugated PMOs for the Treatment of Myotonic Dystrophy.
15932,45101,36401026,10.1007/978-1-0716-2772-3_6,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Restoring Dystrophin Expression by Skipping Exons 6 and 8 in Neonatal Dystrophic Dogs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Restoring Dystrophin Expression by Skipping Exons 6 and 8 in Neonatal Dystrophic Dogs.
15936,45105,36306888,10.1016/j.envpol.2022.120510,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Non-additive mixture effects of benzo[a]pyrene and pesticides in vitro and in vivo: Role of AhR signaling.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Non-additive mixture effects of benzo[a]pyrene and pesticides in vitro and in vivo: Role of AhR signaling.
15949,45118,39439817,10.1080/03036758.2020.1811355,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: The roadmap towards cure of chronic hepatitis B virus infection.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The roadmap towards cure of chronic hepatitis B virus infection.
15951,45120,38069738,10.2533/chimia.2022.236,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Tailoring Design of Nanomaterials and Systems to Individualize Patient Treatments.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tailoring Design of Nanomaterials and Systems to Individualize Patient Treatments.
15962,45131,36421975,10.3390/insects13111072,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic;safety,"toxicity candidate; matched derived terms: toxicity, toxic, safety; source title: Silencing of dre4 Contributes to Mortality of Phyllotreta striolata .",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Silencing of dre4 Contributes to Mortality of Phyllotreta striolata.
15964,45133,36411621,10.1016/j.biopha.2022.113932,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Engineered nanoparticles as emerging gene/drug delivery systems targeting the nuclear factor-κB protein and related signaling pathways in cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineered nanoparticles as emerging gene/drug delivery systems targeting the nuclear factor-κB protein and related signaling pathways in cancer.
15972,45141,36333801,10.1186/s12935-022-02740-6,offtarget,siRNA,PubMed abstract sentence 6,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: Combinatorial targeting of menin and the histone methyltransferase DOT1L as a novel therapeutic strategy for treatment of chemotherapy-resistant ovarian cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Combinatorial targeting of menin and the histone methyltransferase DOT1L as a novel therapeutic strategy for treatment of chemotherapy-resistant ovarian cancer.
15976,45145,36296424,10.3390/molecules27206831,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Assembly of Biologically Functional Structures by Nucleic Acid Templating: Implementation of a Strategy to Overcome Inhibition by Template Excess.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Assembly of Biologically Functional Structures by Nucleic Acid Templating: Implementation of a Strategy to Overcome Inhibition by Template Excess.
15981,45150,36205565,10.18632/aging.204325,offtarget,ASO/siRNA,PubMed abstract sentence 7,transcriptome;silencing,"offtarget candidate; matched derived terms: transcriptome, silencing; source title: APEX1 promotes the oncogenicity of hepatocellular carcinoma via regulation of MAP2K6 .",B,high_candidate,curator_rejected,reject,derived_annotations_only,APEX1 promotes the oncogenicity of hepatocellular carcinoma via regulation of MAP2K6.
15985,45154,36194468,10.1021/acs.jafc.2c04263,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Functional Inquiry into ATP-Binding Cassette Transporter Genes Contributing to Spirotetramat Resistance in Aphis gossypii Glover.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Functional Inquiry into ATP-Binding Cassette Transporter Genes Contributing to Spirotetramat Resistance in Aphis gossypii Glover.
15996,45165,36085230,10.1007/s10565-022-09757-7,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Mechanistic insights into HuR inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and STORM.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Mechanistic insights into HuR inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and STORM.
16007,45176,35834343,10.18087/cardio.2022.6.n2115,toxicity,ASO/siRNA,PubMed abstract sentence 5,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: [Inclisiran - a new era in lipid-lowering therapy].",B,high_candidate,curator_rejected,reject,derived_annotations_only,[Inclisiran - a new era in lipid-lowering therapy].
16008,45177,35819021,10.1039/d2sm00355d,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hollow spherical nucleic acid structures based on polymer-coated phospholipid vesicles.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hollow spherical nucleic acid structures based on polymer-coated phospholipid vesicles.
16011,45180,35804932,10.3390/cancers14133162,offtarget,siRNA,PubMed abstract sentence 10,off-target;seed,"offtarget candidate; matched derived terms: off-target, seed; source title: Knockdown of 15-bp Deletion-Type v-raf Murine Sarcoma Viral Oncogene Homolog B1 mRNA in Pancreatic Ductal Adenocarcinoma Cells Repressed Cell Growth In Vitro and Tumor Volume In Vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Knockdown of 15-bp Deletion-Type v-raf Murine Sarcoma Viral Oncogene Homolog B1 mRNA in Pancreatic Ductal Adenocarcinoma Cells Repressed Cell Growth In Vitro and Tumor Volume In Vivo.
16018,45187,35716694,10.1016/S1474-4422(22)00121-1,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities.
16028,45197,35463672,10.1155/2022/3528786,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead.
16029,45198,35459248,10.1186/s12944-022-01649-3,toxicity,ASO,PubMed abstract sentence 7,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: RNA-based therapy in the management of lipid disorders: a review.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA-based therapy in the management of lipid disorders: a review.
16030,45199,35436511,10.1016/j.ijpharm.2022.121751,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Recent development of aptamer conjugated chitosan nanoparticles as cancer therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Recent development of aptamer conjugated chitosan nanoparticles as cancer therapeutics.
16041,45210,35269876,10.3390/ijms23052736,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Current Advances in RNA Therapeutics for Human Diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Current Advances in RNA Therapeutics for Human Diseases.
16042,45211,35261724,10.1007/s13206-022-00052-5,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Advances in Nanoparticles for Effective Delivery of RNA Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Advances in Nanoparticles for Effective Delivery of RNA Therapeutics.
16043,45212,35222234,10.3389/fneur.2022.664710,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Modified Sensory Testing in Non-verbal Patients Receiving Novel Intrathecal Therapies for Neurological Disorders.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Modified Sensory Testing in Non-verbal Patients Receiving Novel Intrathecal Therapies for Neurological Disorders.
16047,45216,35204815,10.3390/biom12020315,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Insulin-Degrading Enzyme Is a Non Proteasomal Target of Carfilzomib and Affects the 20S Proteasome Inhibition by the Drug.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Insulin-Degrading Enzyme Is a Non Proteasomal Target of Carfilzomib and Affects the 20S Proteasome Inhibition by the Drug.
16048,45217,35189260,10.1016/j.jconrel.2022.02.022,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Dual-RNA controlled delivery system inhibited tumor growth by apoptosis induction and TME activation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Dual-RNA controlled delivery system inhibited tumor growth by apoptosis induction and TME activation.
16049,45218,35168151,10.1016/j.ejmech.2022.114183,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity.
16051,45220,35133835,10.1021/acs.jmedchem.1c01831,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: γ Peptide Nucleic Acid-Based miR-122 Inhibition Rescues Vascular Endothelial Dysfunction in Mice Fed a High-Fat Diet.",B,high_candidate,curator_rejected,reject,derived_annotations_only,γ Peptide Nucleic Acid-Based miR-122 Inhibition Rescues Vascular Endothelial Dysfunction in Mice Fed a High-Fat Diet.
16059,45228,34921016,10.1158/0008-5472.CAN-20-0948,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth.
16060,45229,34915704,10.1021/acs.bioconjchem.1c00456,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Structural Modifications to the Internal Oligoguanidinium Transporter Uncover Two Potent Analogues that Effectively Deliver the Proapoptotic Peptide in Multiple Cancer Cell Lines.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Structural Modifications to the Internal Oligoguanidinium Transporter Uncover Two Potent Analogues that Effectively Deliver the Proapoptotic Peptide in Multiple Cancer Cell Lines.
16064,45233,34799047,10.1016/j.jcis.2021.11.019,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hybridized double-shell periodic mesoporous organosilica nanotheranostics for ultrasound imaging guided photothermal therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hybridized double-shell periodic mesoporous organosilica nanotheranostics for ultrasound imaging guided photothermal therapy.
16068,45237,34711617,10.2967/jnumed.121.262123,toxicity,ASO/siRNA,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Affibody-Mediated PNA-Based Pretargeted Cotreatment Improves Survival of Trastuzumab-Treated Mice Bearing HER2-Expressing Xenografts.
16077,45246,34948105,10.3390/ijms222413314,toxicity,siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Cell Penetrating Peptide-Based Self-Assembly for PD-L1 Targeted Tumor Regression.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cell Penetrating Peptide-Based Self-Assembly for PD-L1 Targeted Tumor Regression.
16084,45253,34681893,10.3390/ijms222011233,toxicity,siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The Role of Nrf2 Transcription Factor and Sp1-Nrf2 Protein Complex in Glutamine Transporter SN1 Regulation in Mouse Cortical Astrocytes Exposed to Ammonia.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The Role of Nrf2 Transcription Factor and Sp1-Nrf2 Protein Complex in Glutamine Transporter SN1 Regulation in Mouse Cortical Astrocytes Exposed to Ammonia.
16086,45255,34677938,10.1021/acsnano.1c04456,toxicity,siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nanoparticle-Mediated In Situ Molecular Reprogramming of Immune Checkpoint Interactions for Cancer Immunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanoparticle-Mediated In Situ Molecular Reprogramming of Immune Checkpoint Interactions for Cancer Immunotherapy.
16089,45258,34566407,10.2147/DDDT.S325790,toxicity,ASO/siRNA,PubMed abstract sentence 10,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: CpG Oligodeoxynucleotide Developed to Activate Primate Immune Responses Promotes Antitumoral Effects in Combination with a Neoantigen-Based mRNA Cancer Vaccine.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,CpG Oligodeoxynucleotide Developed to Activate Primate Immune Responses Promotes Antitumoral Effects in Combination with a Neoantigen-Based mRNA Cancer Vaccine.
16093,45262,34474856,10.1016/j.msec.2021.112305,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic;hematological,"toxicity candidate; matched derived terms: toxicity, toxic, hematological; source title: Folate targeted hybrid lipo-polymeric nanoplexes containing docetaxel and miRNA-34a for breast cancer treatment.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Folate targeted hybrid lipo-polymeric nanoplexes containing docetaxel and miRNA-34a for breast cancer treatment.
16094,45263,34440222,10.3390/biomedicines9081018,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Vivo-Morpholino-Based Antiviral for SARS-CoV-2: Implications for Novel Therapies in the Treatment of Acute COVID-19 Disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Vivo-Morpholino-Based Antiviral for SARS-CoV-2: Implications for Novel Therapies in the Treatment of Acute COVID-19 Disease.
16096,45265,34378168,10.1007/s13311-021-01095-6,toxicity,ASO,PubMed abstract sentence 8,risk;adverse,"toxicity candidate; matched derived terms: risk, adverse; source title: Dravet Syndrome: Novel Approaches for the Most Common Genetic Epilepsy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dravet Syndrome: Novel Approaches for the Most Common Genetic Epilepsy.
16098,45267,34331779,10.1002/hep.32083,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis."
16099,45268,34331650,10.1007/s11356-021-15695-4,toxicity,ASO,PubMed abstract sentence 1,toxic;renal,"toxicity candidate; matched derived terms: toxic, renal; source title: Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats."
16101,45270,34288499,10.1002/cmdc.202100409,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synthesis and Antimicrobial Evaluation of Bis-morpholine Triazine Quaternary Ammonium Salts.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Synthesis and Antimicrobial Evaluation of Bis-morpholine Triazine Quaternary Ammonium Salts.
16105,45274,34258818,10.1002/jmr.2926,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A molecular hybrid comprising AS1411 and PDGF-BB aptamer, cholesterol, and doxorubicin for inhibiting proliferation of SW480 cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"A molecular hybrid comprising AS1411 and PDGF-BB aptamer, cholesterol, and doxorubicin for inhibiting proliferation of SW480 cells."
16106,45275,34251414,10.1182/bloodadvances.2021004233,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Phase 3 randomized trial of chemotherapy with or without oblimersen in older AML patients: CALGB 10201 (Alliance).",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Phase 3 randomized trial of chemotherapy with or without oblimersen in older AML patients: CALGB 10201 (Alliance).
16110,45279,34214617,10.1016/j.biochi.2021.06.013,offtarget,siRNA,PubMed abstract sentence 5,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line.
16111,45280,34214617,10.1016/j.biochi.2021.06.013,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The knockdown efficiency of telomere associated genes with specific methodology in a zebrafish cell line.
16112,45281,34186297,10.1016/j.saa.2021.120100,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A morpholino hydrazone-based lysosome-targeting fluorescent probe with fast response and high sensitivity for imaging peroxynitrite in living cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A morpholino hydrazone-based lysosome-targeting fluorescent probe with fast response and high sensitivity for imaging peroxynitrite in living cells.
16117,45286,34147573,10.1016/j.jconrel.2021.06.022,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Down-regulation of TNF-α via macrophage-targeted RNAi system for the treatment of acute inflammatory sepsis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Down-regulation of TNF-α via macrophage-targeted RNAi system for the treatment of acute inflammatory sepsis.
16119,45288,34145432,10.1038/s41573-021-00219-z,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Noncoding RNA therapeutics - challenges and potential solutions.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Noncoding RNA therapeutics - challenges and potential solutions.
16126,45295,34062235,10.1016/j.bbagen.2021.129938,toxicity,siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Short interfering RNA delivered by a hybrid nanoparticle targeting VEGF: Biodistribution and anti-tumor effect.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Short interfering RNA delivered by a hybrid nanoparticle targeting VEGF: Biodistribution and anti-tumor effect.
16127,45296,34055230,10.1021/acsmedchemlett.1c00079,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Design and Catalyzed Activation of Mycophenolic Acid Prodrugs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Design and Catalyzed Activation of Mycophenolic Acid Prodrugs.
16130,45299,34027284,10.1002/rth2.12509,toxicity,ASO,PubMed abstract sentence 2,safety;renal,"toxicity candidate; matched derived terms: safety, renal; source title: Antithrombotics and new interventions for venous thromboembolism: Exploring possibilities beyond factor IIa and factor Xa inhibition.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antithrombotics and new interventions for venous thromboembolism: Exploring possibilities beyond factor IIa and factor Xa inhibition.
16135,45304,33954091,10.3390/pr9020356,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Overview and Update on Methods for Cargo Loading into Extracellular Vesicles.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Overview and Update on Methods for Cargo Loading into Extracellular Vesicles.
16137,45306,33953843,10.18632/oncotarget.27933,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore.
16138,45307,33937351,10.3389/fcvm.2021.571076,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Unresolved Issues in RNA Therapeutics in Vascular Diseases With a Focus on Aneurysm Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Unresolved Issues in RNA Therapeutics in Vascular Diseases With a Focus on Aneurysm Disease.
16139,45308,33887477,10.1016/j.cbpc.2021.109053,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Anisomycin induces hair cell death and blocks supporting cell proliferation in zebrafish lateral line neuromast.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Anisomycin induces hair cell death and blocks supporting cell proliferation in zebrafish lateral line neuromast.
16152,45321,33742144,10.1038/s41416-021-01297-x,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer.
16159,45328,33544849,10.1093/nar/gkab047,toxicity,ASO,PubMed abstract sentence 1,toxic;safety,"toxicity candidate; matched derived terms: toxic, safety; source title: Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.
16161,45330,33472516,10.1080/15476286.2021.1874161,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: Molecular correction of Duchenne muscular dystrophy by splice modulation and gene editing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Molecular correction of Duchenne muscular dystrophy by splice modulation and gene editing.
16163,45332,33337582,10.15252/emmm.202012993,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MOTS-c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,MOTS-c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice.
16166,45335,33188937,10.1016/j.ymthe.2020.11.008,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Pharmacokinetics and Proceedings in Clinical Application of Nucleic Acid Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pharmacokinetics and Proceedings in Clinical Application of Nucleic Acid Therapeutics.
16168,45337,33085127,10.1002/jat.4059,toxicity,ASO/siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aconitine disrupts serotonin neurotransmission via 5-hydroxytryptamine receptor in zebrafish embryo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aconitine disrupts serotonin neurotransmission via 5-hydroxytryptamine receptor in zebrafish embryo.
16169,45338,32935160,10.1007/s00415-020-10223-9,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic;safety;adverse,"toxicity candidate; matched derived terms: toxicity, toxic, safety, adverse; source title: Nusinersen treatment significantly improves hand grip strength, hand motor function and MRC sum scores in adult patients with spinal muscular atrophy types 3 and 4.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Nusinersen treatment significantly improves hand grip strength, hand motor function and MRC sum scores in adult patients with spinal muscular atrophy types 3 and 4."
16172,45341,32599652,10.1002/cpt.1974,toxicity,ASO/siRNA,PubMed abstract sentence 6,safety;adverse,"toxicity candidate; matched derived terms: safety, adverse; source title: Single-Dose Pharmacokinetics and Pharmacodynamics of Transthyretin Targeting N-acetylgalactosamine-Small Interfering Ribonucleic Acid Conjugate, Vutrisiran, in Healthy Subjects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Single-Dose Pharmacokinetics and Pharmacodynamics of Transthyretin Targeting N-acetylgalactosamine-Small Interfering Ribonucleic Acid Conjugate, Vutrisiran, in Healthy Subjects."
16175,45344,35515636,10.1039/d0ra01435d,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A highly sensitive, selective and renewable carbon paste electrode based on a unique acyclic diamide ionophore for the potentiometric determination of lead ions in polluted water samples.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"A highly sensitive, selective and renewable carbon paste electrode based on a unique acyclic diamide ionophore for the potentiometric determination of lead ions in polluted water samples."
16180,45349,33091667,10.1016/j.bioorg.2020.104344,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic;risk,"toxicity candidate; matched derived terms: toxicity, toxic, risk; source title: Identification of a potent and selective phosphatidylinositol 3-kinase δ inhibitor for the treatment of non-Hodgkin's lymphoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identification of a potent and selective phosphatidylinositol 3-kinase δ inhibitor for the treatment of non-Hodgkin's lymphoma.
16188,45357,32958829,10.1038/s41598-020-71708-1,toxicity,ASO/siRNA,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Deletion of morpholino binding sites (DeMOBS) to assess specificity of morphant phenotypes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Deletion of morpholino binding sites (DeMOBS) to assess specificity of morphant phenotypes.
16197,45366,32805488,10.1016/j.omtn.2020.07.008,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC.
16198,45367,32799680,10.1089/hum.2020.137,toxicity,siRNA,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Treating Cystic Fibrosis with mRNA and CRISPR.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Treating Cystic Fibrosis with mRNA and CRISPR.
16204,45373,32437399,10.1371/journal.pone.0233466,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Delivery of thymoquinone to cancer cells with as1411-conjugated nanodroplets.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery of thymoquinone to cancer cells with as1411-conjugated nanodroplets.
16205,45374,32415122,10.1038/s41467-020-16248-y,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver.
16207,45376,32384158,10.1093/toxsci/kfaa063,toxicity,ASO/siRNA,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Aryl Hydrocarbon Receptor Mediates Larval Zebrafish Fin Duplication Following Exposure to Benzofluoranthenes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Aryl Hydrocarbon Receptor Mediates Larval Zebrafish Fin Duplication Following Exposure to Benzofluoranthenes.
16214,45383,32005803,10.1038/s41467-020-14349-2,toxicity,ASO,PubMed abstract sentence 8,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Preclinical development of a miR-132 inhibitor for heart failure treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Preclinical development of a miR-132 inhibitor for heart failure treatment.
16216,45385,31883987,10.1016/j.fct.2019.111081,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Detection of zearalenone in an aptamer assay using attenuated internal reflection ellipsometry and it's cereal sample applications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Detection of zearalenone in an aptamer assay using attenuated internal reflection ellipsometry and it's cereal sample applications.
16220,45389,31812480,10.1016/j.jhazmat.2019.121720,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Selenomethionine exposure affects chondrogenic differentiation and bone formation in Japanese medaka (Oryzias latipes).",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Selenomethionine exposure affects chondrogenic differentiation and bone formation in Japanese medaka (Oryzias latipes).
16221,45390,31809673,10.1080/07391102.2019.1701554,toxicity,ASO/siRNA,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Molecular dynamics and computational study of Mannich-based coumarin derivatives: potent tyrosine kinase inhibitor.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Molecular dynamics and computational study of Mannich-based coumarin derivatives: potent tyrosine kinase inhibitor.
16223,45392,31787235,10.1016/j.bbrc.2019.11.096,toxicity,ASO/siRNA,PubMed abstract sentence 6,toxicity;toxic;renal,"toxicity candidate; matched derived terms: toxicity, toxic, renal; source title: miR-150 inhibitor ameliorates adriamycin-induced focal segmental glomerulosclerosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,miR-150 inhibitor ameliorates adriamycin-induced focal segmental glomerulosclerosis.
16224,45393,31698196,10.1016/j.ecoenv.2019.109673,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Seasonal variations in the dose-response relationship of acetylcholinesterase activity in freshwater fish exposed to chlorpyrifos and glyphosate.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Seasonal variations in the dose-response relationship of acetylcholinesterase activity in freshwater fish exposed to chlorpyrifos and glyphosate.
16227,45396,30753594,10.1093/ndt/gfz013,toxicity,siRNA,PubMed abstract sentence 9,safety;risk,"toxicity candidate; matched derived terms: safety, risk; source title: New agents to reduce cholesterol levels: implications for nephrologists.",B,high_candidate,curator_rejected,reject,derived_annotations_only,New agents to reduce cholesterol levels: implications for nephrologists.
16228,45397,32038525,10.3389/fmicb.2019.03031,toxicity,ASO/siRNA,PubMed abstract sentence 18,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Development of a Sensitive Escherichia coli Bioreporter Without Antibiotic Markers for Detecting Bioavailable Copper in Water Environments.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of a Sensitive Escherichia coli Bioreporter Without Antibiotic Markers for Detecting Bioavailable Copper in Water Environments.
16230,45399,31683630,10.3390/ijms20215434,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing.
16231,45400,31629961,10.1016/j.omtn.2019.09.012,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Hexose Potentiates Peptide-Conjugated Morpholino Oligomer Efficacy in Cardiac Muscles of Dystrophic Mice in an Age-Dependent Manner.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hexose Potentiates Peptide-Conjugated Morpholino Oligomer Efficacy in Cardiac Muscles of Dystrophic Mice in an Age-Dependent Manner.
16234,45403,31556592,10.1021/acsami.9b14324,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Synthetic α-l-Threose Nucleic Acids Targeting BcL-2 Show Gene Silencing and in Vivo Antitumor Activity for Cancer Therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Synthetic α-l-Threose Nucleic Acids Targeting BcL-2 Show Gene Silencing and in Vivo Antitumor Activity for Cancer Therapy.
16235,45404,31495875,10.1093/nar/gkz771,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.
16239,45408,31234313,10.3390/molecules24122297,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Bridged Nucleic Acids Reloaded.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bridged Nucleic Acids Reloaded.
16241,45410,31036929,10.1038/s41587-019-0106-2,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic;hepatotoxicity,"toxicity candidate; matched derived terms: toxicity, toxic, hepatotoxicity; source title: Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.
16243,45412,30552932,10.1016/j.taap.2018.12.009,toxicity,ASO,PubMed abstract sentence 10,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions.
16246,45415,30465822,10.1016/j.jconrel.2018.11.015,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Drug-free albumin-triggered sensitization of cancer cells to anticancer drugs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Drug-free albumin-triggered sensitization of cancer cells to anticancer drugs.
16247,45416,30462579,10.1091/mbc.E18-07-0460,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ErbB4 tyrosine kinase inhibition impairs neuromuscular development in zebrafish embryos.
16248,45417,30448197,10.1016/j.ymthe.2018.10.011,toxicity,ASO,PubMed abstract sentence 9,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Efficacy of Multi-exon Skipping Treatment in Duchenne Muscular Dystrophy Dog Model Neonates.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Efficacy of Multi-exon Skipping Treatment in Duchenne Muscular Dystrophy Dog Model Neonates.
16252,45421,30195785,10.1016/j.omtn.2018.06.005,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Long-Term Morpholino Oligomers in Hexose Elicits Long-Lasting Therapeutic Improvements in mdx Mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Long-Term Morpholino Oligomers in Hexose Elicits Long-Lasting Therapeutic Improvements in mdx Mice.
16254,45423,30171554,10.1007/978-1-4939-8651-4_23,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: In Vivo Evaluation of Multiple Exon Skipping with Peptide-PMOs in Cardiac and Skeletal Muscles in Dystrophic Dogs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In Vivo Evaluation of Multiple Exon Skipping with Peptide-PMOs in Cardiac and Skeletal Muscles in Dystrophic Dogs.
16256,45425,30171535,10.1007/978-1-4939-8651-4_4,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Nusinersen in the Treatment of Spinal Muscular Atrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nusinersen in the Treatment of Spinal Muscular Atrophy.
16258,45427,29997223,10.1182/blood-2018-03-836601,toxicity,ASO,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92."
16260,45429,29875202,10.1126/scitranslmed.aat0195,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy."
16263,45432,29800498,10.1002/jgm.3025,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity.
16268,45437,29696141,10.3389/fcell.2018.00037,offtarget,ASO,PubMed abstract sentence 16,off-target;silencing,"offtarget candidate; matched derived terms: off-target, silencing; source title: Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish.
16277,45446,29282321,10.1073/pnas.1715124115,toxicity,ASO,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.
16279,45448,29214789,10.3349/ymj.2018.59.1.141,toxicity,ASO,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish.",B,high_candidate,curator_rejected,reject,derived_annotations_only,microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish.
16281,45450,28918018,10.1016/j.omtn.2017.06.012,toxicity,siRNA,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA."
16288,45457,28571947,10.1016/j.bbagen.2017.05.026,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Boron nitride nanotubes for gene silencing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Boron nitride nanotubes for gene silencing.
16291,45460,28373570,10.1073/pnas.1613203114,toxicity,ASO/siRNA,PubMed abstract sentence 11,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy.
16292,45461,28364245,10.1007/978-1-4939-6817-6_17,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy.
16297,45466,28119399,10.1523/JNEUROSCI.3102-16.2017,toxicity,siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na + -Activated K + Channels in Aplysia Neurons.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na(+)-Activated K(+) Channels in Aplysia Neurons.
16303,45472,27890659,10.1016/j.nano.2016.11.015,toxicity,ASO/siRNA,PubMed abstract sentence 7,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: RNA nanoparticles harboring annexin A2 aptamer can target ovarian cancer for tumor-specific doxorubicin delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNA nanoparticles harboring annexin A2 aptamer can target ovarian cancer for tumor-specific doxorubicin delivery.
16306,45475,27939059,10.1016/S0140-6736(16)31408-8,toxicity,ASO,PubMed abstract sentence 3,safety;tolerability,"toxicity candidate; matched derived terms: safety, tolerability; source title: Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study."
16307,45476,27721240,10.1172/JCI83185,toxicity,ASO,PubMed abstract sentence 6,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
16308,45477,27655663,10.18632/oncotarget.12043,toxicity,ASO/siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Locked nucleic acid-inhibitor of miR-205 decreases endometrial cancer cells proliferation in vitro and in vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Locked nucleic acid-inhibitor of miR-205 decreases endometrial cancer cells proliferation in vitro and in vivo.
16310,45479,27378237,10.1038/mt.2016.111,toxicity,ASO,PubMed abstract sentence 4,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics.
16312,45481,27123752,10.1089/nat.2015.0557,toxicity,siRNA,PubMed abstract sentence 5,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Single-Stranded Silencing RNAs: Hit Rate and Chemical Modification.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Single-Stranded Silencing RNAs: Hit Rate and Chemical Modification.
16313,45482,27112072,10.1016/j.bcp.2016.04.012,toxicity,ASO,PubMed abstract sentence 8,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner."
16316,45485,26878886,10.1038/srep21301,toxicity,ASO,PubMed abstract sentence 1,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Morpholino-mediated SOD1 reduction ameliorates an amyotrophic lateral sclerosis disease phenotype.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Morpholino-mediated SOD1 reduction ameliorates an amyotrophic lateral sclerosis disease phenotype.
16317,45486,26810703,10.1039/c5cc07124k,toxicity,ASO/siRNA,PubMed abstract sentence 2,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: The morpholino molecular beacon for specific RNA visualization in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The morpholino molecular beacon for specific RNA visualization in vivo.
16319,45488,26632489,10.1016/j.ydbio.2015.11.018,toxicity,ASO,PubMed abstract sentence 3,toxicity;toxic,"toxicity candidate; matched derived terms: toxicity, toxic; source title: Genome editing in sea urchin embryos by using a CRISPR/Cas9 system.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Genome editing in sea urchin embryos by using a CRISPR/Cas9 system.
38322,67491,24934636,10.1186/1471-2105-15-192,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;mirna-like;mirna;rnai,"full-text off-target candidate; title/source terms=off-target, seed, mirna-like, mirna, rnai; source title: Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis.
38323,67492,38192001,10.1093/bioinformatics/btae011,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;rna-seq;sirna,"full-text off-target candidate; title/source terms=off-target, seed, rna-seq, sirna; source title: SeedMatchR: identify off-target effects mediated by siRNA seed regions in RNA-seq experiments.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SeedMatchR: identify off-target effects mediated by siRNA seed regions in RNA-seq experiments.
38324,67493,29164215,10.1039/c7ob02654d,offtarget,siRNA,PMC full text high-precision preselection,off-target;mirna-like;mirna;sirna,"full-text off-target candidate; title/source terms=off-target, mirna-like, mirna, sirna; source title: Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications.
38325,67494,26839153,10.5483/bmbrep.2016.49.3.019,offtarget,siRNA,PMC full text high-precision preselection,off-target;mirna-like;mirna;sirna,"full-text off-target candidate; title/source terms=off-target, mirna-like, mirna, sirna; source title: Rationally designed siRNAs without miRNA-like off-target repression.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rationally designed siRNAs without miRNA-like off-target repression.
38326,67495,22258146,10.4161/rna.9.1.18121,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;mismatch;sirna,"full-text off-target candidate; title/source terms=off-target, seed, mismatch, sirna; source title: Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7.
38327,67496,22807929,10.3389/fgene.2012.00127,offtarget,siRNA,PMC full text high-precision preselection,specificity;mirna-like;mirna;rnai,"full-text off-target candidate; title/source terms=specificity, mirna-like, mirna, rnai; source title: miRNA-like duplexes as RNAi triggers with improved specificity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,miRNA-like duplexes as RNAi triggers with improved specificity.
38328,67497,18267968,10.1093/nar/gkn042,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;silencing;sirna,"full-text off-target candidate; title/source terms=off-target, seed, silencing, sirna; source title: Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
38329,67498,16682560,10.1261/rna.25706,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;silencing;sirna,"full-text off-target candidate; title/source terms=off-target, seed, silencing, sirna; source title: Widespread siRNA ""off-target"" transcript silencing mediated by seed region sequence complementarity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Widespread siRNA ""off-target"" transcript silencing mediated by seed region sequence complementarity."
38330,67499,15656792,10.1042/BJ20041956,offtarget,siRNA,PMC full text high-precision preselection,specificity;silencing;rnai;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=specificity, silencing, rnai, antisense, oligonucleotide, oligonucleotides; source title: Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi.
38331,67500,41066632,10.1093/hmg/ddaf153,offtarget,ASO,PMC full text high-precision preselection,off-target;rnaseq;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=off-target, rnaseq, antisense, oligonucleotide, oligonucleotides; source title: Determining off-target effects of splice-switching antisense oligonucleotides using short read RNAseq in neuronally differentiated human induced pluripotent stem cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Determining off-target effects of splice-switching antisense oligonucleotides using short read RNAseq in neuronally differentiated human induced pluripotent stem cells.
38332,67501,31802121,10.1093/nar/gkz1132,offtarget,ASO,PMC full text high-precision preselection,off-target;hybridization;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=off-target, hybridization, antisense, oligonucleotide, oligonucleotides; source title: Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides.
38333,67502,34388351,10.1089/nat.2020.0921,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,off-target;transcriptome;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=off-target, transcriptome, oligonucleotide, oligonucleotides; source title: Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides.
38334,67503,33584737,10.3389/fpls.2020.526455,offtarget,siRNA,PMC full text high-precision preselection,off-target;specificity;sirna;rnai,"full-text off-target candidate; title/source terms=off-target, specificity, sirna, rnai; source title: siRNA Specificity: RNAi Mechanisms and Strategies to Reduce Off-Target Effects.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA Specificity: RNAi Mechanisms and Strategies to Reduce Off-Target Effects.
38335,67504,29622040,10.1186/s12951-018-0361-2,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;mismatch;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, mismatch, oligonucleotide, oligonucleotides; source title: Measuring DNA hybridization using fluorescent DNA-stabilized silver clusters to investigate mismatch effects on therapeutic oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Measuring DNA hybridization using fluorescent DNA-stabilized silver clusters to investigate mismatch effects on therapeutic oligonucleotides.
38336,67505,25489607,10.1039/c4an01352b,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, hybridization, oligonucleotide, oligonucleotides; source title: Structured oligonucleotides for target indexing to allow single-vessel PCR amplification and solid support microarray hybridization.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structured oligonucleotides for target indexing to allow single-vessel PCR amplification and solid support microarray hybridization.
38337,67506,25270879,10.1093/nar/gku854,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;rnai;shrna,"full-text off-target candidate; title/source terms=off-target, seed, rnai, shrna; source title: Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs.
38338,67507,18493311,10.1371/journal.pone.0002248,offtarget,siRNA,PMC full text high-precision preselection,mismatch;silencing;sirna;rnai,"full-text off-target candidate; title/source terms=mismatch, silencing, sirna, rnai; source title: Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi.
38339,67508,19117516,10.1186/1471-2164-9-635,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;mismatch;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, mismatch, oligonucleotide, oligonucleotides; source title: Mismatch oligonucleotides in human and yeast: guidelines for probe design on tiling microarrays.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mismatch oligonucleotides in human and yeast: guidelines for probe design on tiling microarrays.
38340,67509,14757833,10.1093/nar/gkh196,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, hybridization, oligonucleotide, oligonucleotides; source title: Guidelines for incorporating non-perfectly matched oligonucleotides into target-specific hybridization probes for a DNA microarray.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Guidelines for incorporating non-perfectly matched oligonucleotides into target-specific hybridization probes for a DNA microarray.
38341,67510,11410672,10.1093/nar/29.12.2626,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;specificity;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, specificity, oligonucleotide, oligonucleotides; source title: Binding specificity and stability of duplexes formed by modified oligonucleotides with a 4096-hexanucleotide microarray.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Binding specificity and stability of duplexes formed by modified oligonucleotides with a 4096-hexanucleotide microarray.
38342,67511,10572170,10.1093/nar/27.24.4710,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, hybridization, oligonucleotide, oligonucleotides; source title: Inversion of in situ synthesized oligonucleotides: improved reagents for hybridization and primer extension in DNA microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inversion of in situ synthesized oligonucleotides: improved reagents for hybridization and primer extension in DNA microarrays.
38343,67512,41994868,10.1093/nar/gkag345,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;sirna,"full-text off-target candidate; title/source terms=off-target, seed, sirna; source title: Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.
38344,67513,40737088,10.1093/nar/gkaf692,offtarget,siRNA,PMC full text high-precision preselection,seed;specificity;sirna,"full-text off-target candidate; title/source terms=seed, specificity, sirna; source title: Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile.
38345,67514,40725189,10.3390/ijms26146943,offtarget,siRNA,PMC full text high-precision preselection,seed;silencing;rnai,"full-text off-target candidate; title/source terms=seed, silencing, rnai; source title: Seed-Specific Silencing of Abundantly Expressed Soybean Bowman-Birk Protease Inhibitor Genes by RNAi Lowers Trypsin and Chymotrypsin Inhibitor Activities and Enhances Protein Digestibility.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Seed-Specific Silencing of Abundantly Expressed Soybean Bowman-Birk Protease Inhibitor Genes by RNAi Lowers Trypsin and Chymotrypsin Inhibitor Activities and Enhances Protein Digestibility.
38346,67515,39231537,10.1093/nar/gkae741,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;sirna,"full-text off-target candidate; title/source terms=off-target, seed, sirna; source title: Synthesis of 2'-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs.",B,high_candidate,curator_verified,accept,derived_annotations_only,Synthesis of 2'-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs.
38347,67516,36003813,10.3389/fpls.2022.935851,offtarget,siRNA,PMC full text high-precision preselection,seed;silencing;rnai,"full-text off-target candidate; title/source terms=seed, silencing, rnai; source title: RNAi silencing of wheat gliadins alters the network of transcription factors that regulate the synthesis of seed storage proteins toward maintaining grain protein levels.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi silencing of wheat gliadins alters the network of transcription factors that regulate the synthesis of seed storage proteins toward maintaining grain protein levels.
38348,67517,34580386,10.1038/s41598-021-98708-z,offtarget,siRNA,PMC full text high-precision preselection,mirna-like;mirna;sirna,"full-text off-target candidate; title/source terms=mirna-like, mirna, sirna; source title: AGO CLIP-based imputation of potent siRNA sequences targeting SARS-CoV-2 with antifibrotic miRNA-like activity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,AGO CLIP-based imputation of potent siRNA sequences targeting SARS-CoV-2 with antifibrotic miRNA-like activity.
38349,67518,33664996,10.1016/j.omtn.2021.01.018,offtarget,siRNA,PMC full text high-precision preselection,mirna-like;mirna;sirna,"full-text off-target candidate; title/source terms=mirna-like, mirna, sirna; source title: AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity.
38350,67519,33397184,10.1080/15476286.2020.1868680,offtarget,siRNA,PMC full text high-precision preselection,off-target;mismatch;rnai,"full-text off-target candidate; title/source terms=off-target, mismatch, rnai; source title: Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA.
38351,67520,31123331,10.1038/s41598-019-44255-7,offtarget,siRNA,PMC full text high-precision preselection,seed;silencing;rnai,"full-text off-target candidate; title/source terms=seed, silencing, rnai; source title: Seed targeted RNAi-mediated silencing of GmMIPS1 limits phytate accumulation and improves mineral bioavailability in soybean.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Seed targeted RNAi-mediated silencing of GmMIPS1 limits phytate accumulation and improves mineral bioavailability in soybean.
38352,67521,29718312,10.1093/nar/gky287,offtarget,siRNA,PMC full text high-precision preselection,mismatch;silencing;sirna,"full-text off-target candidate; title/source terms=mismatch, silencing, sirna; source title: Differences in silencing of mismatched targets by sliced versus diced siRNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Differences in silencing of mismatched targets by sliced versus diced siRNAs.
38353,67522,29413418,10.1016/j.trecan.2017.11.007,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;rnai,"full-text off-target candidate; title/source terms=off-target, seed, rnai; source title: DISE: A Seed-Dependent RNAi Off-Target Effect That Kills Cancer Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,DISE: A Seed-Dependent RNAi Off-Target Effect That Kills Cancer Cells.
38354,67523,30215772,10.1093/nar/gky798,offtarget,siRNA,PMC full text high-precision preselection,off-target;hybridization;sirna,"full-text off-target candidate; title/source terms=off-target, hybridization, sirna; source title: Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition.
38355,67524,29963066,10.3389/fpls.2018.00804,offtarget,siRNA,PMC full text high-precision preselection,seed;silencing;sirna,"full-text off-target candidate; title/source terms=seed, silencing, sirna; source title: Development and Evaluation of Low Phytic Acid Soybean by siRNA Triggered Seed Specific Silencing of Inositol Polyphosphate 6-/3-/5-Kinase Gene.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development and Evaluation of Low Phytic Acid Soybean by siRNA Triggered Seed Specific Silencing of Inositol Polyphosphate 6-/3-/5-Kinase Gene.
38356,67525,29450406,10.1021/acsomega.7b00291,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;sirna,"full-text off-target candidate; title/source terms=off-target, seed, sirna; source title: Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets.
38357,67526,26361354,10.1371/journal.pone.0137640,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;rnai,"full-text off-target candidate; title/source terms=off-target, seed, rnai; source title: Deciphering Seed Sequence Based Off-Target Effects in a Large-Scale RNAi Reporter Screen for E-Cadherin Expression.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Deciphering Seed Sequence Based Off-Target Effects in a Large-Scale RNAi Reporter Screen for E-Cadherin Expression.
38358,67527,25628353,10.1093/nar/gkv050,offtarget,siRNA,PMC full text high-precision preselection,off-target;transcriptome;small interfering,"full-text off-target candidate; title/source terms=off-target, transcriptome, small interfering; source title: Accurate transcriptome-wide prediction of microRNA targets and small interfering RNA off-targets with MIRZA-G.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Accurate transcriptome-wide prediction of microRNA targets and small interfering RNA off-targets with MIRZA-G.
38359,67528,26657993,10.1371/journal.pcbi.1004656,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;sirna,"full-text off-target candidate; title/source terms=off-target, seed, sirna; source title: The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects.
38360,67529,26061033,10.1371/journal.pone.0129010,offtarget,siRNA,PMC full text high-precision preselection,seed;silencing;sirna,"full-text off-target candidate; title/source terms=seed, silencing, sirna; source title: Analysis of the siRNA-Mediated Gene Silencing Process Targeting Three Homologous Genes Controlling Soybean Seed Oil Quality.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Analysis of the siRNA-Mediated Gene Silencing Process Targeting Three Homologous Genes Controlling Soybean Seed Oil Quality.
38361,67530,26450182,10.1186/s12870-015-0625-z,offtarget,siRNA,PMC full text high-precision preselection,seed;silencing;rnai,"full-text off-target candidate; title/source terms=seed, silencing, rnai; source title: Development of marker-free transgenic Jatropha curcas producing curcin-deficient seeds through endosperm-specific RNAi-mediated gene silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of marker-free transgenic Jatropha curcas producing curcin-deficient seeds through endosperm-specific RNAi-mediated gene silencing.
38362,67531,25679211,10.1371/journal.pone.0115328,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;specificity;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, specificity, oligonucleotide; source title: Stereospecificity of oligonucleotide interactions revisited: no evidence for heterochiral hybridization and ribozyme/DNAzyme activity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Stereospecificity of oligonucleotide interactions revisited: no evidence for heterochiral hybridization and ribozyme/DNAzyme activity.
38363,67532,24532782,10.1534/genetics.113.159780,offtarget,siRNA,PMC full text high-precision preselection,off-target;silencing;rnai,"full-text off-target candidate; title/source terms=off-target, silencing, rnai; source title: Nuclear RNAi contributes to the silencing of off-target genes and repetitive sequences in Caenorhabditis elegans.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nuclear RNAi contributes to the silencing of off-target genes and repetitive sequences in Caenorhabditis elegans.
38364,67533,23844166,10.1371/journal.pone.0068161,offtarget,siRNA,PMC full text high-precision preselection,seed;silencing;rnai,"full-text off-target candidate; title/source terms=seed, silencing, rnai; source title: Development of low phytate rice by RNAi mediated seed-specific silencing of inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene (IPK1).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Development of low phytate rice by RNAi mediated seed-specific silencing of inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene (IPK1)."
38365,67534,22229698,10.1089/hum.2011.145,offtarget,siRNA,PMC full text high-precision preselection,off-target;specificity;sirna,"full-text off-target candidate; title/source terms=off-target, specificity, sirna; source title: Asymmetric siRNA: new strategy to improve specificity and reduce off-target gene expression.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Asymmetric siRNA: new strategy to improve specificity and reduce off-target gene expression.
38366,67535,21047800,10.1093/nar/gkq961,offtarget,siRNA,PMC full text high-precision preselection,specificity;silencing;sirna,"full-text off-target candidate; title/source terms=specificity, silencing, sirna; source title: Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs.
38367,67536,21673662,10.1038/mt.2011.109,offtarget,siRNA,PMC full text high-precision preselection,off-target;silencing;sirna,"full-text off-target candidate; title/source terms=off-target, silencing, sirna; source title: Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing.
38368,67537,21853133,10.1371/journal.pone.0023443,offtarget,siRNA,PMC full text high-precision preselection,mismatch;silencing;sirna,"full-text off-target candidate; title/source terms=mismatch, silencing, sirna; source title: Designing of highly effective complementary and mismatch siRNAs for silencing a gene.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Designing of highly effective complementary and mismatch siRNAs for silencing a gene.
38369,67538,20026621,10.1261/rna.1808510,offtarget,siRNA,PMC full text high-precision preselection,off-target;silencing;sirna,"full-text off-target candidate; title/source terms=off-target, silencing, sirna; source title: Intended transcriptional silencing with siRNA results in gene repression through sequence-specific off-targeting.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intended transcriptional silencing with siRNA results in gene repression through sequence-specific off-targeting.
38370,67539,21095568,10.1016/j.chembiol.2010.10.013,offtarget,siRNA,PMC full text high-precision preselection,mirna-like;mirna;rnai,"full-text off-target candidate; title/source terms=mirna-like, mirna, rnai; source title: Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism.
38371,67540,21152036,10.1371/journal.pone.0014178,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, hybridization, oligonucleotide; source title: High-resolution genotyping via whole genome hybridizations to microarrays containing long oligonucleotide probes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,High-resolution genotyping via whole genome hybridizations to microarrays containing long oligonucleotide probes.
38372,67541,20557101,10.1021/bi100286n,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;specificity;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, specificity, oligonucleotide; source title: Comparisons between chemical mapping and binding to isoenergetic oligonucleotide microarrays reveal unexpected patterns of binding to the Bacillus subtilis RNase P RNA specificity domain.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comparisons between chemical mapping and binding to isoenergetic oligonucleotide microarrays reveal unexpected patterns of binding to the Bacillus subtilis RNase P RNA specificity domain.
38373,67542,19948054,10.1186/1471-2105-10-392,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;sirna,"full-text off-target candidate; title/source terms=off-target, seed, sirna; source title: siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect.
38374,67543,19811537,10.1111/j.1742-4658.2009.07364.x,offtarget,siRNA,PMC full text high-precision preselection,mismatch;silencing;sirna,"full-text off-target candidate; title/source terms=mismatch, silencing, sirna; source title: Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efficacy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efficacy.
38375,67544,18420656,10.1093/nar/gkn190,offtarget,siRNA,PMC full text high-precision preselection,mismatch;specificity;sirna,"full-text off-target candidate; title/source terms=mismatch, specificity, sirna; source title: Analysis of siRNA specificity on targets with double-nucleotide mismatches.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Analysis of siRNA specificity on targets with double-nucleotide mismatches.
38376,67545,18367722,10.1261/rna.704708,offtarget,siRNA,PMC full text high-precision preselection,seed;specificity;sirna,"full-text off-target candidate; title/source terms=seed, specificity, sirna; source title: Experimental validation of the importance of seed complement frequency to siRNA specificity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Experimental validation of the importance of seed complement frequency to siRNA specificity.
38377,67546,18988625,10.1093/nar/gkn902,offtarget,siRNA,PMC full text high-precision preselection,off-target;seed;sirna,"full-text off-target candidate; title/source terms=off-target, seed, sirna; source title: Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect.
38378,67547,18385155,10.1093/nar/gkn133,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, hybridization, oligonucleotide; source title: A study of the relationships between oligonucleotide properties and hybridization signal intensities from NimbleGen microarray datasets.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A study of the relationships between oligonucleotide properties and hybridization signal intensities from NimbleGen microarray datasets.
38379,67548,17407579,10.1186/1471-2164-8-89,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, hybridization, oligonucleotide; source title: Cross-species analysis of gene expression in non-model mammals: reproducibility of hybridization on high density oligonucleotide microarrays.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cross-species analysis of gene expression in non-model mammals: reproducibility of hybridization on high density oligonucleotide microarrays.
38380,67549,16682562,10.1261/rna.30706,offtarget,siRNA,PMC full text high-precision preselection,off-target;silencing;sirna,"full-text off-target candidate; title/source terms=off-target, silencing, sirna; source title: Position-specific chemical modification of siRNAs reduces ""off-target"" transcript silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Position-specific chemical modification of siRNAs reduces ""off-target"" transcript silencing."
38381,67550,15781493,10.1093/nar/gki312,offtarget,siRNA,PMC full text high-precision preselection,mismatch;silencing;sirna,"full-text off-target candidate; title/source terms=mismatch, silencing, sirna; source title: A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites.
38382,67551,16091630,10.1093/nar/gki762,offtarget,siRNA,PMC full text high-precision preselection,off-target;silencing;sirna,"full-text off-target candidate; title/source terms=off-target, silencing, sirna; source title: siRNA-mediated off-target gene silencing triggered by a 7 nt complementation.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,siRNA-mediated off-target gene silencing triggered by a 7 nt complementation.
38383,67552,15834006,10.1529/biophysj.104.055343,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, hybridization, oligonucleotide; source title: Specific and nonspecific hybridization of oligonucleotide probes on microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Specific and nonspecific hybridization of oligonucleotide probes on microarrays.
38384,67553,15718295,10.1093/nar/gni029,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,transcriptome;microarray;oligonucleotide,"full-text off-target candidate; title/source terms=transcriptome, microarray, oligonucleotide; source title: Effective transcriptome amplification for expression profiling on sense-oriented oligonucleotide microarrays.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Effective transcriptome amplification for expression profiling on sense-oriented oligonucleotide microarrays.
38385,67554,11071945,10.1093/nar/28.22.4552,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;specificity;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, specificity, oligonucleotide; source title: Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarrays.
38386,67555,34994962,10.1007/s40291-021-00573-z,offtarget,ASO,PMC full text high-precision preselection,off-target;antisense;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=off-target, antisense, gapmer, oligonucleotide, oligonucleotides; source title: Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension.
38387,67556,32125928,10.1089/nat.2020.0847,offtarget,ASO,PMC full text high-precision preselection,hybridization;antisense;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, antisense, gapmer, oligonucleotide, oligonucleotides; source title: Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy.
38388,67557,31637814,10.1111/gtc.12730,offtarget,ASO,PMC full text high-precision preselection,off-target;antisense;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=off-target, antisense, gapmer, oligonucleotide, oligonucleotides; source title: Evaluation of off-target effects of gapmer antisense oligonucleotides using human cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluation of off-target effects of gapmer antisense oligonucleotides using human cells.
38389,67558,41541269,10.1016/j.omtn.2025.102801,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna;rnai;galnac,"full-text off-target candidate; title/source terms=silencing, sirna, rnai, galnac; source title: Ribofuranose-based GalNAc-conjugated siRNA enhances the liver-targeted delivery and elicits robust RNAi-mediated gene silencing.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Ribofuranose-based GalNAc-conjugated siRNA enhances the liver-targeted delivery and elicits robust RNAi-mediated gene silencing.
38390,67559,41127529,10.1039/d5cb00186b,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=silencing, antisense, oligonucleotide, oligonucleotides; source title: Chemically inducible antisense oligonucleotides for cell-specific gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemically inducible antisense oligonucleotides for cell-specific gene silencing.
38391,67560,38993932,10.1016/j.omtn.2024.102237,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense;gapmer;oligonucleotide,"full-text off-target candidate; title/source terms=silencing, antisense, gapmer, oligonucleotide; source title: Strategies to improve the design of gapmer antisense oligonucleotide on allele-specific silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Strategies to improve the design of gapmer antisense oligonucleotide on allele-specific silencing.
38392,67561,38042877,10.1038/s41467-023-43714-0,offtarget,ASO,PMC full text high-precision preselection,off-target;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=off-target, antisense, oligonucleotide, oligonucleotides; source title: Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry.
38393,67562,35667416,10.1016/j.jlr.2022.100237,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=silencing, antisense, oligonucleotide, oligonucleotides; source title: ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy.
38394,67563,36140196,10.3390/biomedicines10092096,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=silencing, antisense, oligonucleotide, oligonucleotides; source title: Multi-Functionalized Heteroduplex Antisense Oligonucleotides for Targeted Intracellular Delivery and Gene Silencing in HeLa Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Multi-Functionalized Heteroduplex Antisense Oligonucleotides for Targeted Intracellular Delivery and Gene Silencing in HeLa Cells.
38395,67564,31936122,10.3390/cells9010137,offtarget,ASO,PMC full text high-precision preselection,mirna;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=mirna, antisense, oligonucleotide, oligonucleotides; source title: RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs.
38396,67565,30772256,10.1016/j.molmet.2019.01.013,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=silencing, antisense, oligonucleotide, oligonucleotides; source title: Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice.
38397,67566,29499955,10.1016/j.omtn.2017.11.004,offtarget,ASO,PMC full text high-precision preselection,hybridization;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, gapmer, oligonucleotide, oligonucleotides; source title: A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides.
38398,67567,29790953,10.1093/nar/gky397,offtarget,ASO,PMC full text high-precision preselection,off-target;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=off-target, antisense, oligonucleotide, oligonucleotides; source title: Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.
38399,67568,28426096,10.1093/nar/gkx056,offtarget,ASO,PMC full text high-precision preselection,specificity;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=specificity, antisense, oligonucleotide, oligonucleotides; source title: Managing the sequence-specificity of antisense oligonucleotides in drug discovery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Managing the sequence-specificity of antisense oligonucleotides in drug discovery.
38400,67569,26433227,10.1093/nar/gkv964,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense;gapmer;oligonucleotide,"full-text off-target candidate; title/source terms=silencing, antisense, gapmer, oligonucleotide; source title: A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells.
38401,67570,25072142,10.1371/journal.pone.0101752,offtarget,ASO,PMC full text high-precision preselection,specificity;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=specificity, antisense, oligonucleotide, oligonucleotides; source title: Defining the factors that contribute to on-target specificity of antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Defining the factors that contribute to on-target specificity of antisense oligonucleotides.
38402,67571,22862291,10.1021/nn301135w,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna;antisense;oligonucleotide,"full-text off-target candidate; title/source terms=silencing, sirna, antisense, oligonucleotide; source title: Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA.
38403,67572,19854938,10.1093/nar/gkp841,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=silencing, antisense, oligonucleotide, oligonucleotides; source title: Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents."
38404,67573,41949334,10.1111/cts.70536,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna;galnac,"full-text off-target candidate; title/source terms=silencing, sirna, galnac; source title: A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Long-Term Human Liver Spheroid Model for Assessing Silencing and Durability of GalNAc-Conjugated siRNAs.
38405,67574,41551726,10.1093/narmme/ugag002,offtarget,ASO,PMC full text high-precision preselection,transcriptome;antisense;oligonucleotide,"full-text off-target candidate; title/source terms=transcriptome, antisense, oligonucleotide; source title: A therapeutic antisense oligonucleotide encompassing 2'-O-methoxyethyl modification triggers unique perturbation of the transcriptome.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A therapeutic antisense oligonucleotide encompassing 2'-O-methoxyethyl modification triggers unique perturbation of the transcriptome.
38406,67575,41041909,10.1002/adhm.202502186,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna;aso,"full-text off-target candidate; title/source terms=silencing, sirna, aso; source title: Silencing Myostatin Using In Vivo Self-Assembled siRNA Protects Against Cancer- and Dexamethasone-Induced Muscle Atrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing Myostatin Using In Vivo Self-Assembled siRNA Protects Against Cancer- and Dexamethasone-Induced Muscle Atrophy.
38407,67576,41732207,10.1016/j.omtn.2026.102848,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,silencing;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=silencing, oligonucleotide, oligonucleotides; source title: Design, validation, and functional impact of oligonucleotides for multigene silencing in Alzheimer's disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Design, validation, and functional impact of oligonucleotides for multigene silencing in Alzheimer's disease."
38408,67577,41048186,10.1002/ps.70265,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai;aso,"full-text off-target candidate; title/source terms=silencing, rnai, aso; source title: RNAi-mediated gene silencing of a 26S proteasome subunit increases mortality of the Japanese beetle Popillia japonica.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi-mediated gene silencing of a 26S proteasome subunit increases mortality of the Japanese beetle Popillia japonica.
38409,67578,40464260,10.1021/acs.analchem.5c00644,offtarget,ASO,PMC full text high-precision preselection,hybridization;antisense;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, antisense, oligonucleotide; source title: Quantitative Determination of Click-Reactive Antisense Oligonucleotide and Its Reactivity in Rat Brains by Hybridization LC-MS/MS to Support Pretargeted PET Imaging.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Quantitative Determination of Click-Reactive Antisense Oligonucleotide and Its Reactivity in Rat Brains by Hybridization LC-MS/MS to Support Pretargeted PET Imaging.
38410,67579,41463125,10.3390/biomedicines13123118,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mirna;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=mirna, oligonucleotide, oligonucleotides; source title: Reversing the Irreversible: miRNA-Targeting Mesyl Phosphoramidate Oligonucleotides Restore Sensitivity to Cisplatin and Doxorubicin of KB-8-5 Epidermoid Carcinoma Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Reversing the Irreversible: miRNA-Targeting Mesyl Phosphoramidate Oligonucleotides Restore Sensitivity to Cisplatin and Doxorubicin of KB-8-5 Epidermoid Carcinoma Cells.
38411,67580,40337520,10.3389/fphar.2025.1576151,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,off-target;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=off-target, oligonucleotide, oligonucleotides; source title: An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells.",B,high_candidate,curator_verified,accept,derived_annotations_only,An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells.
38412,67581,41241774,10.1080/17435889.2025.2584581,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,silencing;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=silencing, oligonucleotide, oligonucleotides; source title: COX-2 gene silencing by laser-assisted oligonucleotides release from remote optical Nano-switches (LORONS) in hepatocellular carcinoma cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,COX-2 gene silencing by laser-assisted oligonucleotides release from remote optical Nano-switches (LORONS) in hepatocellular carcinoma cells.
38413,67582,39906612,10.22038/ijbms.2024.81998.17744,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna;aso,"full-text off-target candidate; title/source terms=silencing, sirna, aso; source title: Nanomolecular silencing of TSC22D4 mRNA via a DNAsome-siRNA for enhancing insulin sensitization in hepatocytes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanomolecular silencing of TSC22D4 mRNA via a DNAsome-siRNA for enhancing insulin sensitization in hepatocytes.
38414,67583,39886125,10.1136/bmjonc-2023-000133,offtarget,ASO,PMC full text high-precision preselection,mismatch;antisense;oligonucleotide,"full-text off-target candidate; title/source terms=mismatch, antisense, oligonucleotide; source title: Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch repair-deficient colorectal cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch repair-deficient colorectal cancer."
38415,67584,39259836,10.1093/cvr/cvae195,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense;oligonucleotide,"full-text off-target candidate; title/source terms=silencing, antisense, oligonucleotide; source title: Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice.
38416,67585,39041663,10.1080/17576180.2024.2368339,offtarget,ASO,PMC full text high-precision preselection,hybridization;antisense;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, antisense, oligonucleotide; source title: Bioanalysis of free antisense oligonucleotide payload from antibody-oligonucleotide conjugate by hybridization LC-MS/MS.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bioanalysis of free antisense oligonucleotide payload from antibody-oligonucleotide conjugate by hybridization LC-MS/MS.
38417,67586,38348869,10.1093/nar/gkae091,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mismatch;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=mismatch, oligonucleotide, oligonucleotides; source title: Transient states during the annealing of mismatched and bulged oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transient states during the annealing of mismatched and bulged oligonucleotides.
38418,67587,39248110,10.1093/nar/gkae778,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Making target sites in large structured RNAs accessible to RNA-cleaving DNAzymes through hybridization with synthetic DNA oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Making target sites in large structured RNAs accessible to RNA-cleaving DNAzymes through hybridization with synthetic DNA oligonucleotides.
38419,67588,37460153,10.1261/rna.079699.123,offtarget,ASO,PMC full text high-precision preselection,hybridization;antisense;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, antisense, oligonucleotide; source title: Localization of unlabeled bepirovirsen antisense oligonucleotide in murine tissues using in situ hybridization and CARS imaging.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Localization of unlabeled bepirovirsen antisense oligonucleotide in murine tissues using in situ hybridization and CARS imaging.
38420,67589,37310197,10.1080/15476286.2023.2223484,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna;rnai,"full-text off-target candidate; title/source terms=mirna, sirna, rnai; source title: Three alternative splicing variants of Loquacious play different roles in miRNA- and siRNA-mediated RNAi pathways in Locusta migratoria.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Three alternative splicing variants of Loquacious play different roles in miRNA- and siRNA-mediated RNAi pathways in Locusta migratoria.
38421,67590,36869666,10.1093/nar/gkad118,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Weak tension accelerates hybridization and dehybridization of short oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Weak tension accelerates hybridization and dehybridization of short oligonucleotides.
38422,67591,35736224,10.1093/nar/gkac539,offtarget,siRNA,PMC full text high-precision preselection,seed;sirna;galnac,"full-text off-target candidate; title/source terms=seed, sirna, galnac; source title: From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.
38423,67592,35464859,10.3389/fgene.2022.791416,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,transcriptome;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=transcriptome, oligonucleotide, oligonucleotides; source title: Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the Transcriptome In Vitro."
38424,67593,36099434,10.1093/nar/gkac784,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides.
38425,67594,36108095,10.1002/chem.202202530,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Oligonucleotides Featuring a Covalently Mercurated 6-Phenylcarbazole Residue as High-Affinity Hybridization Probes for Thiopyrimidine-Containing Sequences.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oligonucleotides Featuring a Covalently Mercurated 6-Phenylcarbazole Residue as High-Affinity Hybridization Probes for Thiopyrimidine-Containing Sequences.
38426,67595,35584176,10.1371/journal.pone.0268575,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Developing predictive hybridization models for phosphorothioate oligonucleotides using high-resolution melting.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Developing predictive hybridization models for phosphorothioate oligonucleotides using high-resolution melting.
38427,67596,33801683,10.3390/ijms22073470,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense;oligonucleotide,"full-text off-target candidate; title/source terms=silencing, antisense, oligonucleotide; source title: Foxp3 Silencing with Antisense Oligonucleotide Improves Immunogenicity of an Adjuvanted Recombinant Vaccine against Sporothrix schenckii.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Foxp3 Silencing with Antisense Oligonucleotide Improves Immunogenicity of an Adjuvanted Recombinant Vaccine against Sporothrix schenckii.
38428,67597,34071840,10.3390/pharmaceutics13060800,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials.
38429,67598,34448043,10.1007/s00425-021-03708-y,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna;rnai,"full-text off-target candidate; title/source terms=silencing, sirna, rnai; source title: Topically delivered 22 nt siRNAs enhance RNAi silencing of endogenous genes in two species.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Topically delivered 22 nt siRNAs enhance RNAi silencing of endogenous genes in two species.
38430,67599,34445083,10.3390/ijms22168378,offtarget,ASO,PMC full text high-precision preselection,transcriptome;antisense;oligonucleotide,"full-text off-target candidate; title/source terms=transcriptome, antisense, oligonucleotide; source title: High Concentration of an ISS-N1-Targeting Antisense Oligonucleotide Causes Massive Perturbation of the Transcriptome.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High Concentration of an ISS-N1-Targeting Antisense Oligonucleotide Causes Massive Perturbation of the Transcriptome.
38431,67600,31251800,10.1093/nar/gkz553,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;sirna;rnai,"full-text off-target candidate; title/source terms=transcriptome, sirna, rnai; source title: Exogenous RNAi mechanisms contribute to transcriptome adaptation by phased siRNA clusters in Paramecium.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exogenous RNAi mechanisms contribute to transcriptome adaptation by phased siRNA clusters in Paramecium.
38432,67601,31462239,10.1186/s12936-019-2925-5,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai;antisense,"full-text off-target candidate; title/source terms=silencing, rnai, antisense; source title: Gene silencing through RNAi and antisense Vivo-Morpholino increases the efficacy of pyrethroids on larvae of Anopheles stephensi.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Gene silencing through RNAi and antisense Vivo-Morpholino increases the efficacy of pyrethroids on larvae of Anopheles stephensi.
38433,67602,31475020,10.3389/fpls.2019.01023,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna;rnai,"full-text off-target candidate; title/source terms=off-target, sirna, rnai; source title: siRNA-Finder (si-Fi) Software for RNAi-Target Design and Off-Target Prediction.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA-Finder (si-Fi) Software for RNAi-Target Design and Off-Target Prediction.
38434,67603,31553600,10.1021/acs.jctc.9b00519,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Molecular Dynamics Study of the Hybridization between RNA and Modified Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Molecular Dynamics Study of the Hybridization between RNA and Modified Oligonucleotides.
38435,67604,31108932,10.3390/genes10050375,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Fluorescence In Situ Hybridization (FISH) Analysis of the Locations of the Oligonucleotides 5S rDNA, (AGGGTTT)(3), and (TTG)(6) in Three Genera of Oleaceae and Their Phylogenetic Framework.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Fluorescence In Situ Hybridization (FISH) Analysis of the Locations of the Oligonucleotides 5S rDNA, (AGGGTTT)(3), and (TTG)(6) in Three Genera of Oleaceae and Their Phylogenetic Framework."
38436,67605,29459660,10.1038/s41467-018-02989-4,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna;galnac,"full-text off-target candidate; title/source terms=off-target, sirna, galnac; source title: Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.
38437,67606,29048135,10.1002/chem.201704338,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction.
38438,67607,29843368,10.3390/ijms19061588,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides.
38439,67608,30385727,10.1172/jci.insight.123193,offtarget,ASO,PMC full text high-precision preselection,transcriptome;antisense;oligonucleotide,"full-text off-target candidate; title/source terms=transcriptome, antisense, oligonucleotide; source title: Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles.
38440,67609,29022758,10.1089/nat.2017.0690,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.
38441,67610,27862816,10.1111/pbi.12664,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna;rnai,"full-text off-target candidate; title/source terms=silencing, sirna, rnai; source title: RNAi-mediated endogene silencing in strawberry fruit: detection of primary and secondary siRNAs by deep sequencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi-mediated endogene silencing in strawberry fruit: detection of primary and secondary siRNAs by deep sequencing.
38442,67611,28032948,10.1002/anie.201610753,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Effect of PEG Architecture on the Hybridization Thermodynamics and Protein Accessibility of PEGylated Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Effect of PEG Architecture on the Hybridization Thermodynamics and Protein Accessibility of PEGylated Oligonucleotides.
38443,67612,26858106,10.1038/srep21666,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;sirna;antisense,"full-text off-target candidate; title/source terms=transcriptome, sirna, antisense; source title: NATpipe: an integrative pipeline for systematical discovery of natural antisense transcripts (NATs) and phase-distributed nat-siRNAs from de novo assembled transcriptomes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,NATpipe: an integrative pipeline for systematical discovery of natural antisense transcripts (NATs) and phase-distributed nat-siRNAs from de novo assembled transcriptomes.
38444,67613,26338776,10.1093/nar/gkv857,offtarget,ASO,PMC full text high-precision preselection,off-target;aso;gapmer,"full-text off-target candidate; title/source terms=off-target, aso, gapmer; source title: In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.
38445,67614,25790000,10.1371/journal.pone.0118549,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna;shrna,"full-text off-target candidate; title/source terms=off-target, sirna, shrna; source title: shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects.
38446,67615,25534009,10.1186/1471-2164-15-1157,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna;rnai,"full-text off-target candidate; title/source terms=silencing, sirna, rnai; source title: Complex coding of endogenous siRNA, transcriptional silencing and H3K9 methylation on native targets of germline nuclear RNAi in C. elegans.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Complex coding of endogenous siRNA, transcriptional silencing and H3K9 methylation on native targets of germline nuclear RNAi in C. elegans."
38447,67616,24338081,10.1074/jbc.M113.531467,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna;small interfering,"full-text off-target candidate; title/source terms=silencing, sirna, small interfering; source title: Hydrolysis rates of different small interfering RNAs (siRNAs) by the RNA silencing promoter complex, C3PO, determines their regulation by phospholipase Cβ.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Hydrolysis rates of different small interfering RNAs (siRNAs) by the RNA silencing promoter complex, C3PO, determines their regulation by phospholipase Cβ."
38448,67617,24440078,10.1016/j.chembiol.2013.12.007,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mirna;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=mirna, oligonucleotide, oligonucleotides; source title: Detection of miRNA expression in intact cells using activatable sensor oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Detection of miRNA expression in intact cells using activatable sensor oligonucleotides.
38449,67618,25213224,10.1039/c4cc05771f,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, oligonucleotide, oligonucleotides; source title: Base-cleavable microarrays for the characterization of DNA and RNA oligonucleotides synthesized in situ by photolithography.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Base-cleavable microarrays for the characterization of DNA and RNA oligonucleotides synthesized in situ by photolithography.
38450,67619,23982190,10.1038/mtna.2013.46,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mirna;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=mirna, oligonucleotide, oligonucleotides; source title: Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier.
38451,67620,23089734,10.1038/mt.2012.160,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna;shrna,"full-text off-target candidate; title/source terms=mirna, sirna, shrna; source title: Embedding siRNA sequences targeting apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Embedding siRNA sequences targeting apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy.
38452,67621,23568259,10.1038/mt.2013.57,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna;rnai,"full-text off-target candidate; title/source terms=silencing, sirna, rnai; source title: Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Gene silencing via RNAi and siRNA quantification in tumor tissue using MEND, a liposomal siRNA delivery system."
38453,67622,23165478,10.1182/blood-2012-01-407742,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,off-target;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=off-target, oligonucleotide, oligonucleotides; source title: Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia.
38454,67623,22700939,10.1093/database/bas027,offtarget,siRNA,PMC full text high-precision preselection,specificity;sirna;rnai,"full-text off-target candidate; title/source terms=specificity, sirna, rnai; source title: RNAiAtlas: a database for RNAi (siRNA) libraries and their specificity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAiAtlas: a database for RNAi (siRNA) libraries and their specificity.
38455,67624,22174840,10.1371/journal.pone.0028580,offtarget,siRNA,PMC full text high-precision preselection,mismatch;sirna;shrna,"full-text off-target candidate; title/source terms=mismatch, sirna, shrna; source title: Improved siRNA/shRNA functionality by mismatched duplex.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Improved siRNA/shRNA functionality by mismatched duplex.
38456,67625,21952166,10.1038/mt.2011.185,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna;rnai,"full-text off-target candidate; title/source terms=off-target, sirna, rnai; source title: Rational design of therapeutic siRNAs: minimizing off-targeting potential to improve the safety of RNAi therapy for Huntington's disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rational design of therapeutic siRNAs: minimizing off-targeting potential to improve the safety of RNAi therapy for Huntington's disease.
38457,67626,21875442,10.1186/1472-6750-11-83,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mismatch;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=mismatch, oligonucleotide, oligonucleotides; source title: Enhanced annealing of mismatched oligonucleotides using a novel melting curve assay allows efficient in vitro discrimination and restriction of a single nucleotide polymorphism.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced annealing of mismatched oligonucleotides using a novel melting curve assay allows efficient in vitro discrimination and restriction of a single nucleotide polymorphism.
38458,67627,20520764,10.1371/journal.pone.0010710,offtarget,siRNA,PMC full text high-precision preselection,microarray;sirna;antisense,"full-text off-target candidate; title/source terms=microarray, sirna, antisense; source title: Analysis of antisense expression by whole genome tiling microarrays and siRNAs suggests mis-annotation of Arabidopsis orphan protein-coding genes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Analysis of antisense expression by whole genome tiling microarrays and siRNAs suggests mis-annotation of Arabidopsis orphan protein-coding genes.
38459,67628,20426847,10.1186/1472-6750-10-34,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, oligonucleotide, oligonucleotides; source title: Detection of tmRNA molecules on microarrays at low temperatures using helper oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Detection of tmRNA molecules on microarrays at low temperatures using helper oligonucleotides.
38460,67629,20693531,10.1093/nar/gkq677,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, oligonucleotide, oligonucleotides; source title: High-quality gene assembly directly from unpurified mixtures of microarray-synthesized oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-quality gene assembly directly from unpurified mixtures of microarray-synthesized oligonucleotides.
38461,67630,19815667,10.1093/nar/gkp835,offtarget,siRNA,PMC full text high-precision preselection,mismatch;sirna;rnai,"full-text off-target candidate; title/source terms=mismatch, sirna, rnai; source title: Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs.
38462,67631,19015129,10.1093/bioinformatics/btn573,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, oligonucleotide, oligonucleotides; source title: Selection of oligonucleotides for whole-genome microarrays with semi-automatic update.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Selection of oligonucleotides for whole-genome microarrays with semi-automatic update.
38463,67632,18398004,10.1073/pnas.0801775105,offtarget,siRNA,PMC full text high-precision preselection,mirna;rnai;shrna,"full-text off-target candidate; title/source terms=mirna, rnai, shrna; source title: Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi.
38464,67633,17880708,10.1186/1471-2105-8-350,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, oligonucleotide, oligonucleotides; source title: Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy.
38465,67634,16381835,10.1093/nar/gkj051,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai;shrna,"full-text off-target candidate; title/source terms=silencing, rnai, shrna; source title: RNAi Codex: a portal/database for short-hairpin RNA (shRNA) gene-silencing constructs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi Codex: a portal/database for short-hairpin RNA (shRNA) gene-silencing constructs.
38466,67635,16373483,10.1261/rna.2235106,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering;antisense,"full-text off-target candidate; title/source terms=silencing, small interfering, antisense; source title: The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells.
38467,67636,17017805,10.1021/ja0637200,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Distance-dependent emission from dye-labeled oligonucleotides on striped Au/Ag nanowires: effect of secondary structure and hybridization efficiency.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Distance-dependent emission from dye-labeled oligonucleotides on striped Au/Ag nanowires: effect of secondary structure and hybridization efficiency.
38468,67637,15767278,10.1093/nar/gki293,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Hybridization properties and enzymatic replication of oligonucleotides containing the photocleavable 7-nitroindole base analog.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hybridization properties and enzymatic replication of oligonucleotides containing the photocleavable 7-nitroindole base analog.
38469,67638,16377780,10.1093/nar/gki1003,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Synthesis and hybridization studies of oligonucleotides containing 1-(2-deoxy-2-alpha-C-hydroxymethyl-beta-D-ribofuranosyl)thymine (2'-alpha-hm-dT).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synthesis and hybridization studies of oligonucleotides containing 1-(2-deoxy-2-alpha-C-hydroxymethyl-beta-D-ribofuranosyl)thymine (2'-alpha-hm-dT).
38470,67639,15333693,10.1093/nar/gkh790,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering;antisense,"full-text off-target candidate; title/source terms=silencing, small interfering, antisense; source title: Relative gene-silencing efficiencies of small interfering RNAs targeting sense and antisense transcripts from the same genetic locus.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Relative gene-silencing efficiencies of small interfering RNAs targeting sense and antisense transcripts from the same genetic locus.
38471,67640,15272300,10.1038/sj.embor.7400207,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna;rnai,"full-text off-target candidate; title/source terms=mirna, sirna, rnai; source title: What's new about RNAi? Meeting on siRNAs and miRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,What's new about RNAi? Meeting on siRNAs and miRNAs.
38472,67641,12366869,10.1186/1471-2105-3-27,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=microarray, oligonucleotide, oligonucleotides; source title: Oliz, a suite of Perl scripts that assist in the design of microarrays using 50mer oligonucleotides from the 3' untranslated region.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Oliz, a suite of Perl scripts that assist in the design of microarrays using 50mer oligonucleotides from the 3' untranslated region."
38473,67642,12409465,10.1093/nar/gkf601,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mismatch;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=mismatch, oligonucleotide, oligonucleotides; source title: 1H NMR determination of base-pair lifetimes in oligonucleotides containing single base mismatches.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,1H NMR determination of base-pair lifetimes in oligonucleotides containing single base mismatches.
38474,67643,11353086,10.1093/nar/29.10.2163,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: Hybridization of 2'-ribose modified mixed-sequence oligonucleotides: thermodynamic and kinetic studies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hybridization of 2'-ribose modified mixed-sequence oligonucleotides: thermodynamic and kinetic studies.
38475,67644,10334335,10.1017/s1355838299982195,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide, oligonucleotides; source title: The folding of large RNAs studied by hybridization to arrays of complementary oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The folding of large RNAs studied by hybridization to arrays of complementary oligonucleotides.
38476,67645,42052104,10.2147/DDDT.S589997,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Safety and Pharmacokinetics of SRN001, a Novel siRNA Drug Targeting Amphiregulin via the SAMiRNA Platform.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Safety and Pharmacokinetics of SRN001, a Novel siRNA Drug Targeting Amphiregulin via the SAMiRNA Platform."
38477,67646,41646886,10.1016/j.omtn.2026.102835,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,off-target;oligonucleotide,"full-text off-target candidate; title/source terms=off-target, oligonucleotide; source title: 2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs.
38478,67647,42040413,10.1021/acsomega.5c10717,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Molecular Dynamics Simulation-Assisted siRNA Design for Dual-Ubiquitinated SKP2 Silencing via Ago2 Anchoring in Breast Cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Molecular Dynamics Simulation-Assisted siRNA Design for Dual-Ubiquitinated SKP2 Silencing via Ago2 Anchoring in Breast Cancer.
38479,67648,41634015,10.1038/s41467-026-68993-1,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model.
38480,67649,41755844,10.1021/jacsau.5c01765,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Taming the Achilles' Heel: A Chemical and Structural Design to Address Off-Target Effects in siRNA Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Taming the Achilles' Heel: A Chemical and Structural Design to Address Off-Target Effects in siRNA Therapeutics.
38481,67650,41587091,10.1182/blood.2025029834,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Silencing of PAI-1 using siRNA-lipid nanoparticles reduces thrombosis and prolongs life span in murine models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing of PAI-1 using siRNA-lipid nanoparticles reduces thrombosis and prolongs life span in murine models.
38482,67651,41491413,10.1186/s12864-025-12447-3,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;rnai,"full-text off-target candidate; title/source terms=transcriptome, rnai; source title: Comparative transcriptome analysis of developmental stages and characterization of core RNAi-related genes in the spittlebug Mahanarva fimbriolata.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comparative transcriptome analysis of developmental stages and characterization of core RNAi-related genes in the spittlebug Mahanarva fimbriolata.
38483,67652,42023652,10.1093/nar/gkag388,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Cell-type-specific ablation of siRNAs by Arabidopsis RTL1 reveals a role of phloem companion cells in systemic post-transcriptional gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cell-type-specific ablation of siRNAs by Arabidopsis RTL1 reveals a role of phloem companion cells in systemic post-transcriptional gene silencing.
38484,67653,41898774,10.3390/ijms27062915,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Functional siRNA Delivery via Jet Nebulization: Proof-of-Concept IL-1ß Silencing in Macrophage-like THP-1 Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Functional siRNA Delivery via Jet Nebulization: Proof-of-Concept IL-1ß Silencing in Macrophage-like THP-1 Cells.
38485,67654,41561442,10.1093/narcan/zcag002,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Identification of siRNA silencing TGFβ1 and VEGFR2 and utility of the combination in targeting immune modulation and angiogenesis in treating melanoma in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of siRNA silencing TGFβ1 and VEGFR2 and utility of the combination in targeting immune modulation and angiogenesis in treating melanoma in vivo.
38486,67655,41511879,10.1016/j.xpro.2025.104323,offtarget,siRNA,PMC full text high-precision preselection,specificity;sirna,"full-text off-target candidate; title/source terms=specificity, sirna; source title: Protocols to evaluate mutant specificity of an oncogene-targeting siRNA using orthogonal in vitro and in vivo approaches.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Protocols to evaluate mutant specificity of an oncogene-targeting siRNA using orthogonal in vitro and in vivo approaches.
38487,67656,41346702,10.7150/thno.121775,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,silencing;oligonucleotide,"full-text off-target candidate; title/source terms=silencing, oligonucleotide; source title: The efficacy of oligonucleotide-based gene therapeutics in gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The efficacy of oligonucleotide-based gene therapeutics in gene silencing.
38488,67657,42147085,10.1021/acs.chemmater.6c00522,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Penetratin Decoration Increases RNAi Silencing Effects of Polymeric Carriers.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Penetratin Decoration Increases RNAi Silencing Effects of Polymeric Carriers.
38489,67658,42042481,10.3390/insects17040439,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-Mediated Silencing of vATPase Subunit E Impairs Larval Development in Plutella xylostella, and Virtual Screening Identifies a Potential Inhibitor.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"RNAi-Mediated Silencing of vATPase Subunit E Impairs Larval Development in Plutella xylostella, and Virtual Screening Identifies a Potential Inhibitor."
38490,67659,41841127,10.1007/s12298-025-01697-w,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-mediated silencing of Vitellogenin receptor and Ryanodine receptor, key genes, by using carbon nanotubes for management of whitefly (Bemisia tabaci).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"RNAi-mediated silencing of Vitellogenin receptor and Ryanodine receptor, key genes, by using carbon nanotubes for management of whitefly (Bemisia tabaci)."
38491,67660,41783786,10.1016/j.omtn.2026.102869,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Selective silencing of expanded CAG repeats: Chemically modified siRNA advances RNA-based therapies for polyglutamine diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Selective silencing of expanded CAG repeats: Chemically modified siRNA advances RNA-based therapies for polyglutamine diseases.
38492,67661,41467115,10.1016/j.omtn.2025.102693,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA.
38493,67662,40723836,10.3390/biom15070965,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,transcriptome;oligonucleotide,"full-text off-target candidate; title/source terms=transcriptome, oligonucleotide; source title: Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Endogenous Ribonucleases: Therapeutic Targeting of the Transcriptome Through Oligonucleotide-Triggered RNA Inactivation.
38494,67663,39645556,10.1245/s10434-024-16682-y,offtarget,ASO,PMC full text high-precision preselection,transcriptome;aso,"full-text off-target candidate; title/source terms=transcriptome, aso; source title: ASO Author Reflections: Decoding Racial Differences in Colon Cancer Transcriptomes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ASO Author Reflections: Decoding Racial Differences in Colon Cancer Transcriptomes.
38495,67664,41315228,10.1038/s41467-025-65799-5,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,off-target;oligonucleotide,"full-text off-target candidate; title/source terms=off-target, oligonucleotide; source title: The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The nucleobase guanine at the 3'-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity.
38496,67665,41446212,10.64898/2025.12.17.693452,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid.
38497,67666,40851466,10.1080/17576180.2025.2548194,offtarget,siRNA,PMC full text high-precision preselection,hybridization;sirna,"full-text off-target candidate; title/source terms=hybridization, sirna; source title: Examining hybridization-based LC-MS methodologies for the bioanalysis of siRNA analytes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Examining hybridization-based LC-MS methodologies for the bioanalysis of siRNA analytes.
38498,67667,40725043,10.3390/ijms26146795,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: siRNA Features-Automated Machine Learning of 3D Molecular Fingerprints and Structures for Therapeutic Off-Target Data.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA Features-Automated Machine Learning of 3D Molecular Fingerprints and Structures for Therapeutic Off-Target Data.
38499,67668,41020503,10.1093/nar/gkaf937,offtarget,siRNA,PMC full text high-precision preselection,off-target;small interfering,"full-text off-target candidate; title/source terms=off-target, small interfering; source title: Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs.
38500,67669,40727077,10.1016/j.mtbio.2025.102075,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: FMRP silencing via siRNA lipid nanoparticles to reprogram the tumor microenvironment and enhance anti-PD-1 efficacy in triple-negative breast cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,FMRP silencing via siRNA lipid nanoparticles to reprogram the tumor microenvironment and enhance anti-PD-1 efficacy in triple-negative breast cancer.
38501,67670,41322616,10.1021/acsomega.5c04845,offtarget,ASO,PMC full text high-precision preselection,transcriptome;aso,"full-text off-target candidate; title/source terms=transcriptome, aso; source title: Integrative Transcriptome and Machine Learning Analysis Uncovers Critical STAT3/GREM2 Signaling Mechanisms in Dexamethasone Treatment of Hashimoto's Thyroiditis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Integrative Transcriptome and Machine Learning Analysis Uncovers Critical STAT3/GREM2 Signaling Mechanisms in Dexamethasone Treatment of Hashimoto's Thyroiditis.
38502,67671,41473322,10.64898/2025.12.16.694641,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system.
38503,67672,40943628,10.3390/ijms26178703,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Knocking on Cells' Door: Strategic Approaches for miRNA and siRNA in Anticancer Therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Knocking on Cells' Door: Strategic Approaches for miRNA and siRNA in Anticancer Therapy.
38504,67673,40927452,10.3389/fmicb.2025.1641192,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNA-Silencing of swnR gene greatly reduced biosynthesis of swainsonine in Alternaria oxytropis without affecting the growth characteristics of leguminous host.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA-Silencing of swnR gene greatly reduced biosynthesis of swainsonine in Alternaria oxytropis without affecting the growth characteristics of leguminous host.
38505,67674,40913527,10.1002/advs.202510802,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Strategic Timing of Gene Silencing: Cellular Kinetics-Based Administration of siRNA for Optimized Photothermal Cancer Treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Strategic Timing of Gene Silencing: Cellular Kinetics-Based Administration of siRNA for Optimized Photothermal Cancer Treatment.
38506,67675,40598893,10.1093/nar/gkaf600,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.
38507,67676,40347142,10.1021/acs.biomac.5c00267,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Poly(2-(diethylamino)ethyl methacrylate)-Functionalized Carbon Nanodots as Theranostic Platforms for siRNA Delivery and Survivin Silencing in Triple-Negative Breast Cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Poly(2-(diethylamino)ethyl methacrylate)-Functionalized Carbon Nanodots as Theranostic Platforms for siRNA Delivery and Survivin Silencing in Triple-Negative Breast Cancer.
38508,67677,39934917,10.1186/s13287-025-04151-6,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Development and evaluation of siRNA-mediated gene silencing strategies for ADO2 therapy utilizing iPSCs model and DMPC-SPIONs delivery system.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development and evaluation of siRNA-mediated gene silencing strategies for ADO2 therapy utilizing iPSCs model and DMPC-SPIONs delivery system.
38509,67678,39648859,10.1080/22221751.2024.2438658,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing in the apicomplexan parasite Babesia microti, blood parasite of veterinary and zoonotic importance."
38510,67679,41669362,10.18699/vjgb-25-124,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Effect of RNAi-mediated silencing of the TaAOS2 gene on phytohormone accumulation, growth and productivity in bread wheat.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Effect of RNAi-mediated silencing of the TaAOS2 gene on phytohormone accumulation, growth and productivity in bread wheat."
38511,67680,41300405,10.3390/biology14111616,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Development of Triangle RNA Nanostructure for Enhancing RNAi-Mediated Control of Botrytis cinerea Through Spray-Induced Gene Silencing Without Extra Nanocarrier.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of Triangle RNA Nanostructure for Enhancing RNAi-Mediated Control of Botrytis cinerea Through Spray-Induced Gene Silencing Without Extra Nanocarrier.
38512,67681,41088451,10.1186/s13071-025-07053-x,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: Control of Aedes albopictus populations by silencing of the vesicular GABA transporter (vgat) and the vesicular monoamine transporter (vmat) genes using recombinant Chlorella shRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Control of Aedes albopictus populations by silencing of the vesicular GABA transporter (vgat) and the vesicular monoamine transporter (vmat) genes using recombinant Chlorella shRNA.
38513,67682,40820572,10.1111/mpp.70140,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi Strategies Against Downy Mildews: Insights Into dsRNA Uptake and Silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi Strategies Against Downy Mildews: Insights Into dsRNA Uptake and Silencing.
38514,67683,40820284,10.1002/adbi.202400698,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Double-Stranded DNA Reduces dsRNA Degradation in the Saliva and Significantly Enhanced RNAi-Mediated Gene Silencing in Halyomorpha halys.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Double-Stranded DNA Reduces dsRNA Degradation in the Saliva and Significantly Enhanced RNAi-Mediated Gene Silencing in Halyomorpha halys.
38515,67684,40654369,10.1016/j.apsb.2025.03.015,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Silencing PTPN2 with nanoparticle-delivered small interfering RNA remodels tumor microenvironment to sensitize immunotherapy in hepatocellular carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing PTPN2 with nanoparticle-delivered small interfering RNA remodels tumor microenvironment to sensitize immunotherapy in hepatocellular carcinoma.
38516,67685,40404656,10.1038/s41467-025-60154-0,offtarget,siRNA,PMC full text high-precision preselection,rna-seq;rnai,"full-text off-target candidate; title/source terms=rna-seq, rnai; source title: Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq.
38517,67686,40349108,10.1016/j.ymthe.2025.05.010,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice.
38518,67687,40037707,10.1093/nar/gkaf144,offtarget,ASO,PMC full text high-precision preselection,silencing;aso,"full-text off-target candidate; title/source terms=silencing, aso; source title: Chemical evolution of ASO-like DNAzymes for effective and extended gene silencing in cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Chemical evolution of ASO-like DNAzymes for effective and extended gene silencing in cells.
38519,67688,39993527,10.1016/j.jbc.2025.108345,offtarget,ASO,PMC full text high-precision preselection,specificity;aso,"full-text off-target candidate; title/source terms=specificity, aso; source title: PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma.
38520,67689,39975282,10.1101/2025.02.02.636107,offtarget,siRNA,PMC full text high-precision preselection,rna-seq;rnai,"full-text off-target candidate; title/source terms=rna-seq, rnai; source title: Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq.
38521,67690,39921320,10.1002/tpg2.20564,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;sirna,"full-text off-target candidate; title/source terms=transcriptome, sirna; source title: An organ-specific transcriptome atlas of Curcuma wenyujin: MicroRNAs, phasiRNAs, and metabolic pathways.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"An organ-specific transcriptome atlas of Curcuma wenyujin: MicroRNAs, phasiRNAs, and metabolic pathways."
38522,67691,40295482,10.1038/s41467-025-57994-1,offtarget,ASO,PMC full text high-precision preselection,transcriptome;aso,"full-text off-target candidate; title/source terms=transcriptome, aso; source title: Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases.
38523,67692,41392379,10.1002/cnr2.70434,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Exploitation of Biocomputational Approaches for siRNA-Mediated Gene Silencing of HPV: A Novel Therapeutic Strategy for Cervical Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exploitation of Biocomputational Approaches for siRNA-Mediated Gene Silencing of HPV: A Novel Therapeutic Strategy for Cervical Cancer.
38524,67693,41312019,10.1016/j.omtn.2025.102751,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Design of bifunctional RNA-binding compounds that can modulate siRNA hydrophobicity for deep penetration and gene silencing in the retina.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Design of bifunctional RNA-binding compounds that can modulate siRNA hydrophobicity for deep penetration and gene silencing in the retina.
38525,67694,41190324,10.3389/fgene.2025.1552009,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense,"full-text off-target candidate; title/source terms=silencing, antisense; source title: A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer.
38526,67695,40004122,10.3390/ijms26041658,offtarget,siRNA,PMC full text high-precision preselection,mirna;shrna,"full-text off-target candidate; title/source terms=mirna, shrna; source title: Clinical Proof-of-Concept of a Non-Gene Editing Technology Using miRNA-Based shRNA to Engineer Allogeneic CAR T-Cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clinical Proof-of-Concept of a Non-Gene Editing Technology Using miRNA-Based shRNA to Engineer Allogeneic CAR T-Cells.
38527,67696,39823241,10.1111/jcmm.70308,offtarget,siRNA,PMC full text high-precision preselection,mirna;shrna,"full-text off-target candidate; title/source terms=mirna, shrna; source title: Effective Reduction of Transgene-Specific Immune Response With rAAV Vectors Co-Expressing miRNA-UL112-5p or ERAP1 shRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effective Reduction of Transgene-Specific Immune Response With rAAV Vectors Co-Expressing miRNA-UL112-5p or ERAP1 shRNA.
38528,67697,40730278,10.1016/j.bcp.2025.117192,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Intracellular fatty acid levels differentially impact target silencing by FDA-approved siRNA drugs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Intracellular fatty acid levels differentially impact target silencing by FDA-approved siRNA drugs.
38529,67698,40808258,10.1016/j.ymthe.2025.08.017,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Optimized chemical structure extends silencing duration of therapeutic siRNAs in dividing cancer and immune cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimized chemical structure extends silencing duration of therapeutic siRNAs in dividing cancer and immune cells.
38530,67699,40179082,10.1371/journal.pone.0321182,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Identification of the co-regulatory siRNAs of ""miRNA→target"" in Oryza sativa.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Identification of the co-regulatory siRNAs of ""miRNA→target"" in Oryza sativa."
38531,67700,40836980,10.3389/fddev.2024.1416737,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Dual conjugation of magnetic nanoparticles with antibodies and siRNA for cell-specific gene silencing in vascular cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dual conjugation of magnetic nanoparticles with antibodies and siRNA for cell-specific gene silencing in vascular cells.
38532,67701,39464033,10.1101/2024.10.14.618042,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Synthesis and characterization of chloroquine-modified albumin-binding siRNA-lipid conjugates for improved intracellular delivery and gene silencing in cancer cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synthesis and characterization of chloroquine-modified albumin-binding siRNA-lipid conjugates for improved intracellular delivery and gene silencing in cancer cells.
38533,67702,39380712,10.1016/j.omtn.2024.102335,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: RAB18 regulates extrahepatic siRNA-mediated gene silencing efficacy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RAB18 regulates extrahepatic siRNA-mediated gene silencing efficacy.
38534,67703,38192611,10.1016/j.omtn.2023.102088,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors.
38535,67704,39588258,10.2147/IJN.S476546,offtarget,ASO,PMC full text high-precision preselection,silencing;gapmer,"full-text off-target candidate; title/source terms=silencing, gapmer; source title: SFRP1-Silencing GapmeR-Loaded Lipid-Polymer Hybrid Nanoparticles for Bone Regeneration in Osteoporosis: Effect of Dosing and Targeting Strategy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SFRP1-Silencing GapmeR-Loaded Lipid-Polymer Hybrid Nanoparticles for Bone Regeneration in Osteoporosis: Effect of Dosing and Targeting Strategy.
38536,67705,38979291,10.1101/2024.06.20.599943,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice.
38537,67706,38549376,10.1016/j.ymthe.2024.03.035,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors.
38538,67707,37644186,10.1007/s00702-023-02687-6,offtarget,ASO,PMC full text high-precision preselection,silencing;aso,"full-text off-target candidate; title/source terms=silencing, aso; source title: A sporadic Parkinson's disease model via silencing of the ubiquitin-proteasome/E3 ligase component, SKP1A.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"A sporadic Parkinson's disease model via silencing of the ubiquitin-proteasome/E3 ligase component, SKP1A."
38539,67708,39274180,10.3390/polym16172547,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices.
38540,67709,39221201,10.1016/j.mtbio.2024.101206,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Targeting DNA damage repair mechanism by using RAD50-silencing siRNA nanoparticles to enhance radiotherapy in triple negative breast cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting DNA damage repair mechanism by using RAD50-silencing siRNA nanoparticles to enhance radiotherapy in triple negative breast cancer.
38541,67710,39068444,10.1186/s12951-024-02700-4,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: PD-L1 siRNA hitched polyethyleneimine-elastase constituting nanovesicle induces tumor immunogenicity and PD-L1 silencing for synergistic antitumor immunotherapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PD-L1 siRNA hitched polyethyleneimine-elastase constituting nanovesicle induces tumor immunogenicity and PD-L1 silencing for synergistic antitumor immunotherapy.
38542,67711,39553720,10.7717/peerj.18214,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Investigation of the efficacy of siRNA-mediated KRAS gene silencing in pancreatic cancer therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Investigation of the efficacy of siRNA-mediated KRAS gene silencing in pancreatic cancer therapy.
38543,67712,39339965,10.3390/v16091489,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-Induced Gene Silencing against Chikungunya and COVID-19: What Have We Learned So Far, and What Is the Way Forward?",B,high_candidate,curator_rejected,reject,derived_annotations_only,"RNAi-Induced Gene Silencing against Chikungunya and COVID-19: What Have We Learned So Far, and What Is the Way Forward?"
38544,67713,38816386,10.1038/s41467-024-48950-6,offtarget,siRNA,PMC full text high-precision preselection,seed;sirna,"full-text off-target candidate; title/source terms=seed, sirna; source title: Targeted suppression of siRNA biogenesis in Arabidopsis pollen promotes triploid seed viability.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted suppression of siRNA biogenesis in Arabidopsis pollen promotes triploid seed viability.
38545,67714,39695393,10.1186/s12864-024-11141-0,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNA silencing and hypoxia challenge indicate that the function of common carp (Cyprinus carpio) hif-1αb genes are tightly linked to hif-1αa and hif-3α genes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA silencing and hypoxia challenge indicate that the function of common carp (Cyprinus carpio) hif-1αb genes are tightly linked to hif-1αa and hif-3α genes.
38546,67715,39528633,10.1038/s41477-024-01844-3,offtarget,siRNA,PMC full text high-precision preselection,hybridization;sirna,"full-text off-target candidate; title/source terms=hybridization, sirna; source title: Dosage-sensitive maternal siRNAs determine hybridization success in Capsella.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dosage-sensitive maternal siRNAs determine hybridization success in Capsella.
38547,67716,38375983,10.1002/alz.13703,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease.
38548,67717,38317592,10.1002/ctm2.1579,offtarget,siRNA,PMC full text high-precision preselection,off-target;small interfering,"full-text off-target candidate; title/source terms=off-target, small interfering; source title: Evaluation of on- and off-target effects of self-assembled epidermal growth factor receptor small interfering RNA delivery system.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluation of on- and off-target effects of self-assembled epidermal growth factor receptor small interfering RNA delivery system.
38549,67718,38310092,10.1038/s41467-024-45385-x,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Tigerfish designs oligonucleotide-based in situ hybridization probes targeting intervals of highly repetitive DNA at the scale of genomes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tigerfish designs oligonucleotide-based in situ hybridization probes targeting intervals of highly repetitive DNA at the scale of genomes.
38550,67719,38285499,10.1021/acs.analchem.3c04166,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Nonaqueous Oxidation in DNA Microarray Synthesis Improves the Oligonucleotide Quality and Preserves Surface Integrity on Gold and Indium Tin Oxide Substrates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nonaqueous Oxidation in DNA Microarray Synthesis Improves the Oligonucleotide Quality and Preserves Surface Integrity on Gold and Indium Tin Oxide Substrates.
38551,67720,37200862,10.1016/j.omtn.2023.04.010,offtarget,ASO,PMC full text high-precision preselection,off-target;antisense,"full-text off-target candidate; title/source terms=off-target, antisense; source title: Block or degrade? Balancing on- and off-target effects of antisense strategies against transcripts with expanded triplet repeats in DM1.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Block or degrade? Balancing on- and off-target effects of antisense strategies against transcripts with expanded triplet repeats in DM1.
38552,67721,37315786,10.1016/j.jbc.2023.104916,offtarget,siRNA,PMC full text high-precision preselection,off-target;shrna,"full-text off-target candidate; title/source terms=off-target, shrna; source title: Disruption of Golgi markers by two RILP-directed shRNAs in neurons: A new role for RILP or a neuron-specific off-target phenotype?",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Disruption of Golgi markers by two RILP-directed shRNAs in neurons: A new role for RILP or a neuron-specific off-target phenotype?
38553,67722,36945482,10.1101/2023.03.08.531742,offtarget,siRNA,PMC full text high-precision preselection,off-target;shrna,"full-text off-target candidate; title/source terms=off-target, shrna; source title: ""Disruption of Golgi markers by two RILP-directed shRNAs in neurons: a new role for RILP or a neuron-specific off-target phenotype?"".",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"""Disruption of Golgi markers by two RILP-directed shRNAs in neurons: a new role for RILP or a neuron-specific off-target phenotype?""."
38554,67723,37554515,10.1016/j.omtn.2023.06.021,offtarget,siRNA,PMC full text high-precision preselection,seed;rnai,"full-text off-target candidate; title/source terms=seed, rnai; source title: An unbiased seed-based RNAi selection screen identifies small RNAs that inhibit androgen signaling and prostate cancer cell growth.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An unbiased seed-based RNAi selection screen identifies small RNAs that inhibit androgen signaling and prostate cancer cell growth.
38555,67724,36838605,10.3390/molecules28041618,offtarget,siRNA,PMC full text high-precision preselection,hybridization;sirna,"full-text off-target candidate; title/source terms=hybridization, sirna; source title: A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF and Tissue Samples.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF and Tissue Samples."
38556,67725,36675165,10.3390/ijms24021641,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.
38557,67726,37799328,10.1016/j.omtn.2023.102038,offtarget,siRNA,PMC full text high-precision preselection,mirna;shrna,"full-text off-target candidate; title/source terms=mirna, shrna; source title: Efficient shRNA-based knockdown of multiple target genes for cell therapy using a chimeric miRNA cluster platform.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficient shRNA-based knockdown of multiple target genes for cell therapy using a chimeric miRNA cluster platform.
38558,67727,37561342,10.1245/s10434-023-14069-z,offtarget,ASO,PMC full text high-precision preselection,mismatch;aso,"full-text off-target candidate; title/source terms=mismatch, aso; source title: ASO Author Reflections: Clinical Outcome After Upfront Curative-Intent Local Treatment of Metastases in Patient with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ASO Author Reflections: Clinical Outcome After Upfront Curative-Intent Local Treatment of Metastases in Patient with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer.
38559,67728,36446522,10.26508/lsa.202201801,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes.
38560,67729,38037736,10.1002/cam4.6772,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Gene silencing of Helicobacter pylori through newly designed siRNA convenes the treatment of gastric cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gene silencing of Helicobacter pylori through newly designed siRNA convenes the treatment of gastric cancer.
38561,67730,37467023,10.1182/bloodadvances.2023010643,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Small interfering RNA-mediated allele-selective silencing of von Willebrand factor in vitro and in vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Small interfering RNA-mediated allele-selective silencing of von Willebrand factor in vitro and in vivo.
38562,67731,37031547,10.1016/j.biomaterials.2023.122098,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing."
38563,67732,35071927,10.1021/acsomega.1c06455,offtarget,siRNA,PMC full text high-precision preselection,seed;sirna,"full-text off-target candidate; title/source terms=seed, sirna; source title: siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2'-OMe Modifications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2'-OMe Modifications.
38564,67733,36412852,10.3390/jfb13040211,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: PEGylated Strontium Sulfite Nanoparticles with Spontaneously Formed Surface-Embedded Protein Corona Restrict Off-Target Distribution and Accelerate Breast Tumour-Selective Delivery of siRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PEGylated Strontium Sulfite Nanoparticles with Spontaneously Formed Surface-Embedded Protein Corona Restrict Off-Target Distribution and Accelerate Breast Tumour-Selective Delivery of siRNA.
38565,67734,36229039,10.1093/nar/gkac838,offtarget,ASO,PMC full text high-precision preselection,off-target;antisense,"full-text off-target candidate; title/source terms=off-target, antisense; source title: INRI-seq enables global cell-free analysis of translation initiation and off-target effects of antisense inhibitors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,INRI-seq enables global cell-free analysis of translation initiation and off-target effects of antisense inhibitors.
38566,67735,35205363,10.3390/genes13020319,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects.",B,high_candidate,curator_verified,accept,derived_annotations_only,The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects.
38567,67736,35356684,10.1016/j.omtn.2022.02.019,offtarget,siRNA,PMC full text high-precision preselection,specificity;shrna,"full-text off-target candidate; title/source terms=specificity, shrna; source title: VEGFA-targeting miR-agshRNAs combine efficacy with specificity and safety for retinal gene therapy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,VEGFA-targeting miR-agshRNAs combine efficacy with specificity and safety for retinal gene therapy.
38568,67737,36276652,10.7150/thno.77830,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,specificity;oligonucleotide,"full-text off-target candidate; title/source terms=specificity, oligonucleotide; source title: Specificity of oligonucleotide gene therapy (OGT) agents.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Specificity of oligonucleotide gene therapy (OGT) agents.
38569,67738,36192390,10.1038/s41467-022-33061-x,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models.
38570,67739,35847173,10.1016/j.omtn.2022.06.009,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.
38571,67740,35251767,10.1016/j.omtn.2022.02.004,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Engineering miRNA features into siRNAs: Guide-strand bulges are compatible with gene repression.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineering miRNA features into siRNAs: Guide-strand bulges are compatible with gene repression.
38572,67741,34879171,10.1002/chem.202103995,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Chemically Synthesized, Self-Assembling Small Interfering RNA-Prohead RNA Molecules Trigger Dicer-Independent Gene Silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Chemically Synthesized, Self-Assembling Small Interfering RNA-Prohead RNA Molecules Trigger Dicer-Independent Gene Silencing."
38573,67742,35107128,10.1242/bio.059092,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencing.
38574,67743,36445136,10.1128/mcb.00271-22,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Small Interfering RNAs Targeting a Chromatin-Associated RNA Induce Its Transcriptional Silencing in Human Cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Small Interfering RNAs Targeting a Chromatin-Associated RNA Induce Its Transcriptional Silencing in Human Cells.
38575,67744,35228265,10.1136/jitc-2021-003928,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Immune checkpoint silencing using RNAi-incorporated nanoparticles enhances antitumor immunity and therapeutic efficacy compared with antibody-based approaches.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Immune checkpoint silencing using RNAi-incorporated nanoparticles enhances antitumor immunity and therapeutic efficacy compared with antibody-based approaches.
38576,67745,35327662,10.3390/biom12030470,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: PD-L1 Silencing in Liver Using siRNAs Enhances Efficacy of Therapeutic Vaccination for Chronic Hepatitis B.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PD-L1 Silencing in Liver Using siRNAs Enhances Efficacy of Therapeutic Vaccination for Chronic Hepatitis B.
38577,67746,36234948,10.3390/molecules27196412,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Cheminformatics Modeling of Gene Silencing for Both Natural and Chemically Modified siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cheminformatics Modeling of Gene Silencing for Both Natural and Chemically Modified siRNAs.
38578,67747,35409359,10.3390/ijms23073999,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Microfluidic-Based Cationic Cholesterol Lipid siRNA Delivery Nanosystem: Highly Efficient In Vitro Gene Silencing and the Intracellular Behavior.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Microfluidic-Based Cationic Cholesterol Lipid siRNA Delivery Nanosystem: Highly Efficient In Vitro Gene Silencing and the Intracellular Behavior.
38579,67748,35241750,10.1038/s41598-022-07554-0,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Designing siRNA/chitosan-methacrylate complex nanolipogel for prolonged gene silencing effects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Designing siRNA/chitosan-methacrylate complex nanolipogel for prolonged gene silencing effects.
38580,67749,35041392,10.1021/acsami.1c22434,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Specific Silencing of Microglial Gene Expression in the Rat Brain by Nanoparticle-Based Small Interfering RNA Delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Specific Silencing of Microglial Gene Expression in the Rat Brain by Nanoparticle-Based Small Interfering RNA Delivery.
38581,67750,36253148,10.1002/advs.202203257,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium.
38582,67751,35037064,10.1093/nar/gkab1289,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Nuclear and cytoplasmic RNA exosomes and PELOTA1 prevent miRNA-induced secondary siRNA production in Arabidopsis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nuclear and cytoplasmic RNA exosomes and PELOTA1 prevent miRNA-induced secondary siRNA production in Arabidopsis.
38583,67752,35482116,10.1186/s43141-022-00346-z,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Design of siRNA molecules for silencing of membrane glycoprotein, nucleocapsid phosphoprotein, and surface glycoprotein genes of SARS-CoV2.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Design of siRNA molecules for silencing of membrane glycoprotein, nucleocapsid phosphoprotein, and surface glycoprotein genes of SARS-CoV2."
38584,67753,35885924,10.3390/genes13071141,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi Mediated Gene Silencing of Detoxification Related Genes in the Ectropis oblique.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi Mediated Gene Silencing of Detoxification Related Genes in the Ectropis oblique.
38585,67754,35404142,10.1089/nat.2021.0100,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Improvements to Hybridization-Ligation ELISA Methods to Overcome Bioanalytical Challenges Posed by Novel Oligonucleotide Therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Improvements to Hybridization-Ligation ELISA Methods to Overcome Bioanalytical Challenges Posed by Novel Oligonucleotide Therapeutics.
38586,67755,34281175,10.3390/ijms22137124,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Single Copy Oligonucleotide Fluorescence In Situ Hybridization Probe Design Platforms: Development, Application and Evaluation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Single Copy Oligonucleotide Fluorescence In Situ Hybridization Probe Design Platforms: Development, Application and Evaluation."
38587,67756,33960617,10.1111/pbi.13610,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Chorus2: design of genome-scale oligonucleotide-based probes for fluorescence in situ hybridization.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Chorus2: design of genome-scale oligonucleotide-based probes for fluorescence in situ hybridization.
38588,67757,32311310,10.1089/nat.2020.0852,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Pharmacodynamic and Pharmacokinetic Properties of Full Phosphorothioate Small Interfering RNAs for Gene Silencing In Vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pharmacodynamic and Pharmacokinetic Properties of Full Phosphorothioate Small Interfering RNAs for Gene Silencing In Vivo.
38589,67758,32749923,10.1089/nat.2020.0857,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Modulating Polymer-siRNA Binding Does Not Promote Polyplex-Mediated Silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modulating Polymer-siRNA Binding Does Not Promote Polyplex-Mediated Silencing.
38590,67759,34522211,10.7150/thno.62642,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry.
38591,67760,33321203,10.1016/j.ygeno.2020.12.021,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: A computational approach to design potential siRNA molecules as a prospective tool for silencing nucleocapsid phosphoprotein and surface glycoprotein gene of SARS-CoV-2.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A computational approach to design potential siRNA molecules as a prospective tool for silencing nucleocapsid phosphoprotein and surface glycoprotein gene of SARS-CoV-2.
38592,67761,33580817,10.1007/s00424-021-02521-6,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart.
38593,67762,33984653,10.1016/j.compbiolchem.2021.107486,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Designing potential siRNA molecule for the nucleocapsid(N) gene silencing of different SARS-CoV-2 strains of Bangladesh: Computational approach.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Designing potential siRNA molecule for the nucleocapsid(N) gene silencing of different SARS-CoV-2 strains of Bangladesh: Computational approach.
38594,67763,33818475,10.4103/ijmr.IJMR_2855_20,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Prediction of potential small interfering RNA molecules for silencing of the spike gene of SARS-CoV-2.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Prediction of potential small interfering RNA molecules for silencing of the spike gene of SARS-CoV-2.
38595,67764,33982891,10.1002/art.41794,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle-Based Small Interfering RNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle-Based Small Interfering RNA.
38596,67765,34775377,10.18632/aging.203696,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Small interfering RNA-induced silencing lncRNA PVT1 inhibits atherosclerosis via inactivating the MAPK/NF-κB pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Small interfering RNA-induced silencing lncRNA PVT1 inhibits atherosclerosis via inactivating the MAPK/NF-κB pathway.
38597,67766,34150939,10.21769/BioProtoc.4032,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: In vivo CD40 Silencing by siRNA Infusion in Rodents and Evaluation by Kidney Immunostaining.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vivo CD40 Silencing by siRNA Infusion in Rodents and Evaluation by Kidney Immunostaining.
38598,67767,33946562,10.3390/insects12050406,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-Mediated Silencing of the Chitinase 5 Gene for Fall Webworm (Hyphantria cunea) Can Inhibit Larval Molting Depending on the Timing of dsRNA Injection.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi-Mediated Silencing of the Chitinase 5 Gene for Fall Webworm (Hyphantria cunea) Can Inhibit Larval Molting Depending on the Timing of dsRNA Injection.
38599,67768,33525755,10.3390/insects12020115,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Silencing of Double-Stranded Ribonuclease Improves Oral RNAi Efficacy in Southern Green Stinkbug Nezaraviridula.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing of Double-Stranded Ribonuclease Improves Oral RNAi Efficacy in Southern Green Stinkbug Nezaraviridula.
38600,67769,34644072,10.1021/jacs.1c05219,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Determining Sequence-Dependent DNA Oligonucleotide Hybridization and Dehybridization Mechanisms Using Coarse-Grained Molecular Simulation, Markov State Models, and Infrared Spectroscopy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Determining Sequence-Dependent DNA Oligonucleotide Hybridization and Dehybridization Mechanisms Using Coarse-Grained Molecular Simulation, Markov State Models, and Infrared Spectroscopy."
38601,67770,34226720,10.1038/s41592-021-01187-3,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,transcriptome;oligonucleotide,"full-text off-target candidate; title/source terms=transcriptome, oligonucleotide; source title: PaintSHOP enables the interactive design of transcriptome- and genome-scale oligonucleotide FISH experiments.",B,high_candidate,curator_rejected,reject,derived_annotations_only,PaintSHOP enables the interactive design of transcriptome- and genome-scale oligonucleotide FISH experiments.
38602,67771,34387660,10.1042/BSR20211428,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Molecular subtyping of breast cancer intrinsic taxonomy with oligonucleotide microarray and NanoString nCounter.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Molecular subtyping of breast cancer intrinsic taxonomy with oligonucleotide microarray and NanoString nCounter.
38603,67772,32610253,10.1016/j.omtn.2020.05.010,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: 2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA.
38604,67773,32967608,10.1186/s12864-020-07070-3,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;rnai,"full-text off-target candidate; title/source terms=transcriptome, rnai; source title: Metabolic and transcriptome responses of RNAi-mediated AMPKα knockdown in Tribolium castaneum.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Metabolic and transcriptome responses of RNAi-mediated AMPKα knockdown in Tribolium castaneum.
38605,67774,32059541,10.3390/biom10020285,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth.
38606,67775,32818923,10.1016/j.omtn.2020.07.029,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy.
38607,67776,32184426,10.1038/s41598-020-60078-3,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;sirna,"full-text off-target candidate; title/source terms=transcriptome, sirna; source title: First transcriptome of the Neotropical pest Euschistus heros (Hemiptera: Pentatomidae) with dissection of its siRNA machinery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,First transcriptome of the Neotropical pest Euschistus heros (Hemiptera: Pentatomidae) with dissection of its siRNA machinery.
38608,67777,32541052,10.1073/pnas.2001332117,offtarget,siRNA,PMC full text high-precision preselection,seed;sirna,"full-text off-target candidate; title/source terms=seed, sirna; source title: Abundant expression of maternal siRNAs is a conserved feature of seed development.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Abundant expression of maternal siRNAs is a conserved feature of seed development.
38609,67778,31872227,10.1093/nar/gkz1178,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;sirna,"full-text off-target candidate; title/source terms=transcriptome, sirna; source title: Widespread roles for piRNAs and WAGO-class siRNAs in shaping the germline transcriptome of Caenorhabditis elegans.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Widespread roles for piRNAs and WAGO-class siRNAs in shaping the germline transcriptome of Caenorhabditis elegans.
38610,67779,33077493,10.1105/tpc.20.00562,offtarget,siRNA,PMC full text high-precision preselection,seed;small interfering,"full-text off-target candidate; title/source terms=seed, small interfering; source title: Soybean DICER-LIKE2 Regulates Seed Coat Color via Production of Primary 22-Nucleotide Small Interfering RNAs from Long Inverted Repeats.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Soybean DICER-LIKE2 Regulates Seed Coat Color via Production of Primary 22-Nucleotide Small Interfering RNAs from Long Inverted Repeats.
38611,67780,32945442,10.3892/mmr.2020.11419,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Effect of pre‑freezing and saccharide types in freeze‑drying of siRNA lipoplexes on gene‑silencing effects in the cells by reverse transfection.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of pre‑freezing and saccharide types in freeze‑drying of siRNA lipoplexes on gene‑silencing effects in the cells by reverse transfection.
38612,67781,32240058,10.1089/nat.2019.0831,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: MYCN Silencing by RNAi Induces Neurogenesis and Suppresses Proliferation in Models of Neuroblastoma with Resistance to Retinoic Acid.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MYCN Silencing by RNAi Induces Neurogenesis and Suppresses Proliferation in Models of Neuroblastoma with Resistance to Retinoic Acid.
38613,67782,33243730,10.12122/j.issn.1673-4254.2020.11.18,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: [Effect of small interfering RNA-mediated BIRC6 silencing on apoptosis and autophagy of renal cancer 786-O cells].",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,[Effect of small interfering RNA-mediated BIRC6 silencing on apoptosis and autophagy of renal cancer 786-O cells].
38614,67783,33000194,10.3892/mmr.2020.11525,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene‑silencing effects and siRNA biodistribution in mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene‑silencing effects and siRNA biodistribution in mice.
38615,67784,33020600,10.1038/s41551-020-00623-7,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche.
38616,67785,33304100,10.2147/IJN.S270441,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Silencing of MEF2D by siRNA Loaded Selenium Nanoparticles for Ovarian Cancer Therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing of MEF2D by siRNA Loaded Selenium Nanoparticles for Ovarian Cancer Therapy.
38617,67786,31939276,10.1021/acsami.9b21214,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy.
38618,67787,33199638,10.1073/pnas.1922187117,offtarget,ASO,PMC full text high-precision preselection,transcriptome;antisense,"full-text off-target candidate; title/source terms=transcriptome, antisense; source title: Transcriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CRE Escherichia coli.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transcriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CRE Escherichia coli.
38619,67788,31393218,10.1089/nat.2019.0782,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing.
38620,67789,30901578,10.1016/j.omtn.2019.02.013,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation.
38621,67790,31383907,10.1038/s41598-019-47799-w,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy."
38622,67791,30670041,10.1186/s12951-019-0444-8,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway.
38623,67792,31510678,10.1093/bioinformatics/btz334,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Learning signaling networks from combinatorial perturbations by exploiting siRNA off-target effects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Learning signaling networks from combinatorial perturbations by exploiting siRNA off-target effects.
38624,67793,31084536,10.1089/nat.2019.0792,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Effect of Sugar 2',4'-Modifications on Gene Silencing Activity of siRNA Duplexes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Effect of Sugar 2',4'-Modifications on Gene Silencing Activity of siRNA Duplexes."
38625,67794,31489374,10.1126/sciadv.aax0801,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Covalently tethering siRNA to hydrogels for localized, controlled release and gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Covalently tethering siRNA to hydrogels for localized, controlled release and gene silencing."
38626,67795,30896882,10.3892/mmr.2019.10055,offtarget,ASO,PMC full text high-precision preselection,silencing;aso,"full-text off-target candidate; title/source terms=silencing, aso; source title: Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Keratin 6A gene silencing suppresses cell invasion and metastasis of nasopharyngeal carcinoma via the β‑catenin cascade.
38627,67796,31548628,10.1038/s41598-019-49997-y,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;rnai,"full-text off-target candidate; title/source terms=transcriptome, rnai; source title: Using de novo transcriptome assembly and analysis to study RNAi in Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Using de novo transcriptome assembly and analysis to study RNAi in Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae).
38628,67797,29860520,10.1093/nar/gky437,offtarget,siRNA,PMC full text high-precision preselection,specificity;rnai,"full-text off-target candidate; title/source terms=specificity, rnai; source title: Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis."
38629,67798,30143435,10.1016/j.ymthe.2018.08.005,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
38630,67799,29787571,10.1371/journal.pone.0196979,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;rnai,"full-text off-target candidate; title/source terms=transcriptome, rnai; source title: RNAi screening of subtracted transcriptomes reveals tumor suppression by taurine-activated GABAA receptors involved in volume regulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi screening of subtracted transcriptomes reveals tumor suppression by taurine-activated GABAA receptors involved in volume regulation.
38631,67800,30321353,10.1093/database/bay109,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: siAbasic: a comprehensive database for potent siRNA-6Ø sequences without off-target effects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siAbasic: a comprehensive database for potent siRNA-6Ø sequences without off-target effects.
38632,67801,29662165,10.1038/s41588-018-0104-1,offtarget,siRNA,PMC full text high-precision preselection,seed;rnai,"full-text off-target candidate; title/source terms=seed, rnai; source title: Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics.
38633,67802,30161200,10.1371/journal.pone.0202798,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Silencing efficiency of dsRNA fragments targeting Fusarium graminearum TRI6 and patterns of small interfering RNA associated with reduced virulence and mycotoxin production.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing efficiency of dsRNA fragments targeting Fusarium graminearum TRI6 and patterns of small interfering RNA associated with reduced virulence and mycotoxin production.
38634,67803,30044813,10.1371/journal.pone.0200207,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Expansion of Capsicum annuum fruit is linked to dynamic tissue-specific differential expression of miRNA and siRNA profiles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Expansion of Capsicum annuum fruit is linked to dynamic tissue-specific differential expression of miRNA and siRNA profiles.
38635,67804,29944833,10.1021/acsnano.7b08777,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Rationally Designed Polycationic Carriers for Potent Polymeric siRNA-Mediated Gene Silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rationally Designed Polycationic Carriers for Potent Polymeric siRNA-Mediated Gene Silencing.
38636,67805,30027625,10.1111/mpp.12728,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Secondary amplification of siRNA machinery limits the application of spray-induced gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Secondary amplification of siRNA machinery limits the application of spray-induced gene silencing.
38637,67806,30255786,10.1186/s12864-018-5028-8,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: SiRNA silencing efficacy prediction based on a deep architecture.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SiRNA silencing efficacy prediction based on a deep architecture.
38638,67807,29986635,10.1177/1533033818784411,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: Silencing of ENO1 by shRNA Inhibits the Proliferation of Gastric Cancer Cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing of ENO1 by shRNA Inhibits the Proliferation of Gastric Cancer Cells.
38639,67808,30470739,10.1038/s41467-018-07101-4,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila.
38640,67809,28941315,10.1111/pbi.12845,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Host-induced silencing of essential genes in Puccinia triticina through transgenic expression of RNAi sequences reduces severity of leaf rust infection in wheat.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Host-induced silencing of essential genes in Puccinia triticina through transgenic expression of RNAi sequences reduces severity of leaf rust infection in wheat.
38641,67810,29773839,10.1038/s41598-018-25655-7,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Layer-by-layer siRNA/poly(L-lysine) Multilayers on Polydopamine-coated Surface for Efficient Cell Adhesion and Gene Silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Layer-by-layer siRNA/poly(L-lysine) Multilayers on Polydopamine-coated Surface for Efficient Cell Adhesion and Gene Silencing.
38642,67811,29654062,10.1158/1535-7163.MCT-17-1144,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs.
38643,67812,29461120,10.1080/10717544.2018.1440667,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: Follicle-stimulating hormone peptide-conjugated nanoparticles for targeted shRNA delivery lead to effective gro-α silencing and antitumor activity against ovarian cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Follicle-stimulating hormone peptide-conjugated nanoparticles for targeted shRNA delivery lead to effective gro-α silencing and antitumor activity against ovarian cancer.
38644,67813,29748250,10.1136/thoraxjnl-2017-210670,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung.
38645,67814,29567662,10.1105/tpc.17.00842,offtarget,siRNA,PMC full text high-precision preselection,seed;sirna,"full-text off-target candidate; title/source terms=seed, sirna; source title: Wheat miR9678 Affects Seed Germination by Generating Phased siRNAs and Modulating Abscisic Acid/Gibberellin Signaling.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Wheat miR9678 Affects Seed Germination by Generating Phased siRNAs and Modulating Abscisic Acid/Gibberellin Signaling.
38646,67815,29509999,10.1111/pbi.12915,offtarget,siRNA,PMC full text high-precision preselection,seed;rnai,"full-text off-target candidate; title/source terms=seed, rnai; source title: Seed-specific RNAi in safflower generates a superhigh oleic oil with extended oxidative stability.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Seed-specific RNAi in safflower generates a superhigh oleic oil with extended oxidative stability.
38647,67816,29387734,10.1016/j.omtm.2017.12.005,offtarget,siRNA,PMC full text high-precision preselection,off-target;rnai,"full-text off-target candidate; title/source terms=off-target, rnai; source title: Pre-clinical Safety and Off-Target Studies to Support Translation of AAV-Mediated RNAi Therapy for FSHD.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pre-clinical Safety and Off-Target Studies to Support Translation of AAV-Mediated RNAi Therapy for FSHD.
38648,67817,29246303,10.1016/j.omtn.2017.10.003,offtarget,siRNA,PMC full text high-precision preselection,specificity;sirna,"full-text off-target candidate; title/source terms=specificity, sirna; source title: Site-Specific Modification Using the 2'-Methoxyethyl Group Improves the Specificity and Activity of siRNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Site-Specific Modification Using the 2'-Methoxyethyl Group Improves the Specificity and Activity of siRNAs.
38649,67818,28966945,10.21769/BioProtoc.2501,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,silencing;oligonucleotide,"full-text off-target candidate; title/source terms=silencing, oligonucleotide; source title: A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics.
38650,67819,28108657,10.1093/nar/gkw1325,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: RIsearch2: suffix array-based large-scale prediction of RNA-RNA interactions and siRNA off-targets.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RIsearch2: suffix array-based large-scale prediction of RNA-RNA interactions and siRNA off-targets.
38651,67820,28784979,10.3791/55803,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers.
38652,67821,29138277,10.1101/gad.297796.117,offtarget,siRNA,PMC full text high-precision preselection,rna-seq;shrna,"full-text off-target candidate; title/source terms=rna-seq, shrna; source title: Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.
38653,67822,28855687,10.1038/s41598-017-10219-y,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Library siRNA-generating RNA nanosponges for gene silencing by complementary rolling circle transcription.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Library siRNA-generating RNA nanosponges for gene silencing by complementary rolling circle transcription.
38654,67823,28739942,10.1073/pnas.1621240114,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing."
38655,67824,29034317,10.1523/ENEURO.0186-17.2017,offtarget,siRNA,PMC full text high-precision preselection,off-target;shrna,"full-text off-target candidate; title/source terms=off-target, shrna; source title: Luciferase shRNA Presents off-Target Effects on Voltage-Gated Ion Channels in Mouse Hippocampal Pyramidal Neurons.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Luciferase shRNA Presents off-Target Effects on Voltage-Gated Ion Channels in Mouse Hippocampal Pyramidal Neurons.
38656,67825,28542329,10.1371/journal.pone.0177935,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: Novel AgoshRNA molecules for silencing of the CCR5 co-receptor for HIV-1 infection.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel AgoshRNA molecules for silencing of the CCR5 co-receptor for HIV-1 infection.
38657,67826,29063830,10.7554/eLife.29702,offtarget,siRNA,PMC full text high-precision preselection,off-target;shrna,"full-text off-target candidate; title/source terms=off-target, shrna; source title: Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism.
38658,67827,28148541,10.1530/ERC-16-0482,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Silencing the roadblocks to effective triple-negative breast cancer treatments by siRNA nanoparticles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing the roadblocks to effective triple-negative breast cancer treatments by siRNA nanoparticles.
38659,67828,28331096,10.1128/JVI.00247-17,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;small interfering,"full-text off-target candidate; title/source terms=transcriptome, small interfering; source title: Comprehensive Transcriptome Analyses Reveal that Potato Spindle Tuber Viroid Triggers Genome-Wide Changes in Alternative Splicing, Inducible trans-Acting Activity of Phased Secondary Small Interfering RNAs, and Immune Responses.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Comprehensive Transcriptome Analyses Reveal that Potato Spindle Tuber Viroid Triggers Genome-Wide Changes in Alternative Splicing, Inducible trans-Acting Activity of Phased Secondary Small Interfering RNAs, and Immune Responses."
38660,67829,27957800,10.1111/jcmm.13040,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9-dependent NF-κB and P38MAPKs pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9-dependent NF-κB and P38MAPKs pathway.
38661,67830,27903888,10.1093/nar/gkw1171,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
38662,67831,27697601,10.1016/j.actbio.2016.09.045,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Overcoming cisplatin resistance in non-small cell lung cancer with Mad2 silencing siRNA delivered systemically using EGFR-targeted chitosan nanoparticles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Overcoming cisplatin resistance in non-small cell lung cancer with Mad2 silencing siRNA delivered systemically using EGFR-targeted chitosan nanoparticles.
38663,67832,27381745,10.1111/pbi.12598,offtarget,siRNA,PMC full text high-precision preselection,seed;rnai,"full-text off-target candidate; title/source terms=seed, rnai; source title: Genetic enhancement of palmitic acid accumulation in cotton seed oil through RNAi down-regulation of ghKAS2 encoding β-ketoacyl-ACP synthase II (KASII).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Genetic enhancement of palmitic acid accumulation in cotton seed oil through RNAi down-regulation of ghKAS2 encoding β-ketoacyl-ACP synthase II (KASII).
38664,67833,28464849,10.1186/s12864-017-3720-8,offtarget,ASO,PMC full text high-precision preselection,transcriptome;antisense,"full-text off-target candidate; title/source terms=transcriptome, antisense; source title: Transcriptome analysis of smut fungi reveals widespread intergenic transcription and conserved antisense transcript expression.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Transcriptome analysis of smut fungi reveals widespread intergenic transcription and conserved antisense transcript expression.
38665,67834,27903889,10.1093/nar/gkw1173,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Elasticity of the transition state for oligonucleotide hybridization.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Elasticity of the transition state for oligonucleotide hybridization.
38666,67835,29052679,10.1039/c7ob02353g,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,transcriptome;oligonucleotide,"full-text off-target candidate; title/source terms=transcriptome, oligonucleotide; source title: Oligonucleotide modifications enhance probe stability for single cell transcriptome in vivo analysis (TIVA).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oligonucleotide modifications enhance probe stability for single cell transcriptome in vivo analysis (TIVA).
38667,67836,28053122,10.1093/nar/gkw1339,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mismatch;oligonucleotide,"full-text off-target candidate; title/source terms=mismatch, oligonucleotide; source title: A 'Semi-Protected Oligonucleotide Recombination' Assay for DNA Mismatch Repair in vivo Suggests Different Modes of Repair for Lagging Strand Mismatches.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A 'Semi-Protected Oligonucleotide Recombination' Assay for DNA Mismatch Repair in vivo Suggests Different Modes of Repair for Lagging Strand Mismatches.
38668,67837,27506293,10.1038/mt.2016.126,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.
38669,67838,27483025,10.1038/mtna.2016.55,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.
38670,67839,27083402,10.1016/j.ymeth.2016.04.003,offtarget,siRNA,PMC full text high-precision preselection,mirna;shrna,"full-text off-target candidate; title/source terms=mirna, shrna; source title: Guidelines for the optimal design of miRNA-based shRNAs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Guidelines for the optimal design of miRNA-based shRNAs.
38671,67840,27053374,10.1038/mt.2016.69,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: Engineering Periodic shRNA for Enhanced Silencing Efficacy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Engineering Periodic shRNA for Enhanced Silencing Efficacy.
38672,67841,27387838,10.1021/jacs.6b06137,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Structure-Guided Control of siRNA Off-Target Effects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Structure-Guided Control of siRNA Off-Target Effects.
38673,67842,27731539,10.1002/cbic.201600453,offtarget,siRNA,PMC full text high-precision preselection,specificity;sirna,"full-text off-target candidate; title/source terms=specificity, sirna; source title: Guide Strand 3'-End Modifications Regulate siRNA Specificity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Guide Strand 3'-End Modifications Regulate siRNA Specificity.
38674,67843,27977714,10.1371/journal.pone.0167867,offtarget,siRNA,PMC full text high-precision preselection,off target;shrna,"full-text off-target candidate; title/source terms=off target, shrna; source title: Off Target, but Sequence-Specific, shRNA-Associated Trans-Activation of Promoter Reporters in Transient Transfection Assays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Off Target, but Sequence-Specific, shRNA-Associated Trans-Activation of Promoter Reporters in Transient Transfection Assays."
38675,67844,26699502,10.1073/pnas.1519273113,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies.
38676,67845,28092499,10.1109/TNB.2016.2621730,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Nanoparticles for siRNA-Based Gene Silencing in Tumor Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nanoparticles for siRNA-Based Gene Silencing in Tumor Therapy.
38677,67846,26100539,10.1038/mp.2015.80,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration.
38678,67847,27853365,10.2147/IJN.S117611,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Gene-silencing effects of anti-survivin siRNA delivered by RGDV-functionalized nanodiamond carrier in the breast carcinoma cell line MCF-7.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Gene-silencing effects of anti-survivin siRNA delivered by RGDV-functionalized nanodiamond carrier in the breast carcinoma cell line MCF-7.
38679,67848,27478375,10.2147/IJN.S104090,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Silencing tumor necrosis factor-alpha in vitro from small interfering RNA-decorated titanium nanotube array can facilitate osteogenic differentiation of mesenchymal stem cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing tumor necrosis factor-alpha in vitro from small interfering RNA-decorated titanium nanotube array can facilitate osteogenic differentiation of mesenchymal stem cells.
38680,67849,27501079,10.3791/54210,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing.
38681,67850,27754828,10.17305/bjbms.2016.1568,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study.
38682,67851,27633442,10.1038/mt.2016.179,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Niemann-Pick C1 Inhibitor NP3.47 Enhances Gene Silencing Potency of Lipid Nanoparticles Containing siRNA.
38683,67852,27893850,10.1371/journal.pone.0167222,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: A Convenient In Vivo Model Using Small Interfering RNA Silencing to Rapidly Assess Skeletal Gene Function.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Convenient In Vivo Model Using Small Interfering RNA Silencing to Rapidly Assess Skeletal Gene Function.
38684,67853,27244195,10.1002/smll.201503866,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing.
38685,67854,27600599,10.3892/mmr.2016.5711,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: Histone deacetylase enzyme silencing using shRNAs enhances radiosensitivity of SW579 thyroid cancer cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Histone deacetylase enzyme silencing using shRNAs enhances radiosensitivity of SW579 thyroid cancer cells.
38686,67855,25816689,10.1111/pbi.12362,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Simple gene silencing using the trans-acting siRNA pathway.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Simple gene silencing using the trans-acting siRNA pathway.
38687,67856,27528390,10.1007/s11095-016-2016-z,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Enhanced Anti-Tumor Efficacy of Lipid-Modified Platinum Derivatives in Combination with Survivin Silencing siRNA in Resistant Non-Small Cell Lung Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhanced Anti-Tumor Efficacy of Lipid-Modified Platinum Derivatives in Combination with Survivin Silencing siRNA in Resistant Non-Small Cell Lung Cancer.
38688,67857,27673562,10.1038/mtna.2016.66,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments.
38689,67858,26625198,10.18632/oncotarget.6423,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.
38690,67859,27886062,10.3390/ijms17111956,offtarget,ASO,PMC full text high-precision preselection,microarray;aso,"full-text off-target candidate; title/source terms=microarray, aso; source title: Microarray Expression Profiling of Long Non-Coding RNAs Involved in Nasopharyngeal Carcinoma Metastasis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Microarray Expression Profiling of Long Non-Coding RNAs Involved in Nasopharyngeal Carcinoma Metastasis.
38691,67860,26170322,10.1073/pnas.1510476112,offtarget,siRNA,PMC full text high-precision preselection,off-target;shrna,"full-text off-target candidate; title/source terms=off-target, shrna; source title: Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys.
38692,67861,25919280,10.3390/molecules20057602,offtarget,siRNA,PMC full text high-precision preselection,mismatch;sirna,"full-text off-target candidate; title/source terms=mismatch, sirna; source title: Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units.
38693,67862,26197079,10.1371/journal.pone.0131370,offtarget,siRNA,PMC full text high-precision preselection,seed;rnai,"full-text off-target candidate; title/source terms=seed, rnai; source title: Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects.
38694,67863,26057633,10.18632/oncotarget.4269,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells.
38695,67864,25668122,10.1080/15476286.2015.1014759,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: HIV-1 RRE RNA acts as an RNA silencing suppressor by competing with TRBP-bound siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,HIV-1 RRE RNA acts as an RNA silencing suppressor by competing with TRBP-bound siRNAs.
38696,67865,25973065,,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-mediated silencing of praline-rich gene causes growth reduction in human lung cancer cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi-mediated silencing of praline-rich gene causes growth reduction in human lung cancer cells.
38697,67866,25856158,10.1371/journal.pone.0122581,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Enhanced gene silencing through human serum albumin-mediated delivery of polyethylenimine-siRNA polyplexes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced gene silencing through human serum albumin-mediated delivery of polyethylenimine-siRNA polyplexes.
38698,67867,25530259,10.1002/adhm.201400671,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Light-mediated activation of siRNA Release in diblock copolymer assemblies for controlled gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Light-mediated activation of siRNA Release in diblock copolymer assemblies for controlled gene silencing.
38699,67868,25848254,10.2147/IJN.S76513,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Chitosan/siRNA functionalized titanium surface via a layer-by-layer approach for in vitro sustained gene silencing and osteogenic promotion.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Chitosan/siRNA functionalized titanium surface via a layer-by-layer approach for in vitro sustained gene silencing and osteogenic promotion.
38700,67869,26080908,10.1038/mt.2015.113,offtarget,siRNA,PMC full text high-precision preselection,mirna;shrna,"full-text off-target candidate; title/source terms=mirna, shrna; source title: miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction.
38701,67870,26031528,10.3760/cma.j.issn.0253-2727.2015.05.011,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: [Effect of shRNA-mediated silencing of BDNF gene on VEGF expression of RPMI8226 cells].",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,[Effect of shRNA-mediated silencing of BDNF gene on VEGF expression of RPMI8226 cells].
38702,67871,26593819,10.1038/srep17035,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route.
38703,67872,26582366,10.1038/ncomms9899,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: SUMOylation of TARBP2 regulates miRNA/siRNA efficiency.",B,high_candidate,curator_rejected,reject,derived_annotations_only,SUMOylation of TARBP2 regulates miRNA/siRNA efficiency.
38704,67873,25724840,10.1007/s00262-015-1668-6,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8(+) T cells in NOD/SCID/IL2Rg(null) mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8(+) T cells in NOD/SCID/IL2Rg(null) mice.
38705,67874,26041815,10.1093/hmg/ddv206,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: DICER/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,DICER/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD.
38706,67875,25873251,10.3892/ijmm.2015.2177,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Silencing of uncoupling protein 2 by small interfering RNA aggravates mitochondrial dysfunction in cardiomyocytes under septic conditions.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing of uncoupling protein 2 by small interfering RNA aggravates mitochondrial dysfunction in cardiomyocytes under septic conditions.
38707,67876,26045737,,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: shRNA-mediated silencing of sorcin increases drug chemosensitivity in myeloma KM3/DDP and U266/ADM cell lines.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,shRNA-mediated silencing of sorcin increases drug chemosensitivity in myeloma KM3/DDP and U266/ADM cell lines.
38708,67877,26306628,10.1186/s12864-015-1841-5,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;rnai,"full-text off-target candidate; title/source terms=transcriptome, rnai; source title: De novo transcriptome assembly and analysis to identify potential gene targets for RNAi-mediated control of the tomato leafminer (Tuta absoluta).",B,high_candidate,curator_rejected,reject,derived_annotations_only,De novo transcriptome assembly and analysis to identify potential gene targets for RNAi-mediated control of the tomato leafminer (Tuta absoluta).
38709,67878,26607231,10.1186/s12864-015-2208-7,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Development and validation of a mixed-tissue oligonucleotide DNA microarray for Atlantic bluefin tuna, Thunnus thynnus (Linnaeus, 1758).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Development and validation of a mixed-tissue oligonucleotide DNA microarray for Atlantic bluefin tuna, Thunnus thynnus (Linnaeus, 1758)."
38710,67879,24308267,10.1021/nn4053827,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Cell surface self-assembly of hybrid nanoconjugates via oligonucleotide hybridization induces apoptosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cell surface self-assembly of hybrid nanoconjugates via oligonucleotide hybridization induces apoptosis.
38711,67880,24517546,10.1186/1476-4598-13-27,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes.
38712,67881,24743655,10.1158/1541-7786.MCR-13-0286-T,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;shrna,"full-text off-target candidate; title/source terms=transcriptome, shrna; source title: Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans.
38713,67882,24527979,10.1089/nat.2013.0466,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Target gene abundance contributes to the efficiency of siRNA-mediated gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Target gene abundance contributes to the efficiency of siRNA-mediated gene silencing.
38714,67883,24875475,10.1093/nar/gku480,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: siPools: highly complex but accurately defined siRNA pools eliminate off-target effects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,siPools: highly complex but accurately defined siRNA pools eliminate off-target effects.
38715,67884,24723138,10.1007/s11033-014-3348-6,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi silencing of the SoxE gene suppresses cell proliferation in silkworm BmN4 cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi silencing of the SoxE gene suppresses cell proliferation in silkworm BmN4 cells.
38716,67885,24637581,10.1371/journal.pone.0091996,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Gene silencing of SOCS3 by siRNA intranasal delivery inhibits asthma phenotype in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gene silencing of SOCS3 by siRNA intranasal delivery inhibits asthma phenotype in mice.
38717,67886,24561616,10.1093/nar/gku153,offtarget,siRNA,PMC full text high-precision preselection,seed;sirna,"full-text off-target candidate; title/source terms=seed, sirna; source title: Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells."
38718,67887,24382894,10.1126/scitranslmed.3007048,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice.
38719,67888,25120761,,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-mediated silencing of the Skp-2 gene causes inhibition of growth and induction of apoptosis in human renal carcinoma cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi-mediated silencing of the Skp-2 gene causes inhibition of growth and induction of apoptosis in human renal carcinoma cells.
38720,67889,24650883,10.1016/j.nano.2014.03.006,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Hybrid lipid-polymer nanoparticles for sustained siRNA delivery and gene silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Hybrid lipid-polymer nanoparticles for sustained siRNA delivery and gene silencing.
38721,67890,24987961,10.1371/journal.pone.0100676,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Discovery of a dicer-independent, cell-type dependent alternate targeting sequence generator: implications in gene silencing & pooled RNAi screens.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Discovery of a dicer-independent, cell-type dependent alternate targeting sequence generator: implications in gene silencing & pooled RNAi screens."
38722,67891,24397987,10.1016/j.biomaterials.2013.12.026,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Gene silencing in human aortic smooth muscle cells induced by PEI-siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gene silencing in human aortic smooth muscle cells induced by PEI-siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts.
38723,67892,25223783,10.1093/nar/gku831,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA.
38724,67893,25356812,10.1371/journal.pone.0110051,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Novel miRNA and phasiRNA biogenesis networks in soybean roots from two sister lines that are resistant and susceptible to SCN race 4.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Novel miRNA and phasiRNA biogenesis networks in soybean roots from two sister lines that are resistant and susceptible to SCN race 4.
38725,67894,24791003,10.1155/2014/901617,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Synthesis and gene silencing properties of siRNAs containing terminal amide linkages.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synthesis and gene silencing properties of siRNAs containing terminal amide linkages.
38726,67895,24945770,10.1016/j.neuron.2014.04.036,offtarget,siRNA,PMC full text high-precision preselection,off-target;shrna,"full-text off-target candidate; title/source terms=off-target, shrna; source title: Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous microRNA dysregulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous microRNA dysregulation.
38727,67896,24694542,10.3390/ijms15045570,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: RETRACTED: Silencing of Ether à go-go 1 by shRNA inhibits osteosarcoma growth and cell cycle progression.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RETRACTED: Silencing of Ether à go-go 1 by shRNA inhibits osteosarcoma growth and cell cycle progression.
38728,67897,24972830,10.1093/nar/gku306,offtarget,siRNA,PMC full text high-precision preselection,off-target;rnai,"full-text off-target candidate; title/source terms=off-target, rnai; source title: Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens.
38729,67898,24498319,10.1371/journal.pone.0087390,offtarget,siRNA,PMC full text high-precision preselection,mismatch;shrna,"full-text off-target candidate; title/source terms=mismatch, shrna; source title: Introduction of mismatches in a random shRNA-encoding library improves potency for phenotypic selection.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Introduction of mismatches in a random shRNA-encoding library improves potency for phenotypic selection.
38730,67899,23928214,10.1016/j.nano.2013.07.016,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Phospholipid-modified polyethylenimine-based nanopreparations for siRNA-mediated gene silencing: implications for transfection and the role of lipid components.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phospholipid-modified polyethylenimine-based nanopreparations for siRNA-mediated gene silencing: implications for transfection and the role of lipid components.
38731,67900,24692076,10.1002/adhm.201400103,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy.
38732,67901,25207650,10.1371/journal.pone.0107019,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: Silencing of the hTERT gene by shRNA inhibits colon cancer SW480 cell growth in vitro and in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing of the hTERT gene by shRNA inhibits colon cancer SW480 cell growth in vitro and in vivo.
38733,67902,24821812,10.1073/pnas.1406228111,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice.
38734,67903,25157280,10.7150/thno.7866,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Megalin-mediated specific uptake of chitosan/siRNA nanoparticles in mouse kidney proximal tubule epithelial cells enables AQP1 gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Megalin-mediated specific uptake of chitosan/siRNA nanoparticles in mouse kidney proximal tubule epithelial cells enables AQP1 gene silencing.
38735,67904,25449884,10.1016/j.jconrel.2014.10.022,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation.
38736,67905,24647477,10.1104/pp.113.234989,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: New generation of artificial MicroRNA and synthetic trans-acting small interfering RNA vectors for efficient gene silencing in Arabidopsis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,New generation of artificial MicroRNA and synthetic trans-acting small interfering RNA vectors for efficient gene silencing in Arabidopsis.
38737,67906,24634674,10.3389/fgene.2014.00043,offtarget,siRNA,PMC full text high-precision preselection,rna-seq;rnai,"full-text off-target candidate; title/source terms=rna-seq, rnai; source title: Quality assessment and control of tissue specific RNA-seq libraries of Drosophila transgenic RNAi models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Quality assessment and control of tissue specific RNA-seq libraries of Drosophila transgenic RNAi models.
38738,67907,25157472,10.1021/ac502192w,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Near-infrared silver cluster optically signaling oligonucleotide hybridization and assembling two DNA hosts.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Near-infrared silver cluster optically signaling oligonucleotide hybridization and assembling two DNA hosts.
38739,67908,24742004,10.1186/1756-0500-7-251,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mismatch;oligonucleotide,"full-text off-target candidate; title/source terms=mismatch, oligonucleotide; source title: Influence of the length of target DNA overhang proximal to the array surface on discrimination of single-base mismatches on a 25-mer oligonucleotide array.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Influence of the length of target DNA overhang proximal to the array surface on discrimination of single-base mismatches on a 25-mer oligonucleotide array.
38740,67909,24170218,10.1007/s11033-013-2817-7,offtarget,siRNA,PMC full text high-precision preselection,off-target;shrna,"full-text off-target candidate; title/source terms=off-target, shrna; source title: Off-target effects of plasmid-transcribed shRNAs on NFκB signaling pathway and cell survival of human melanoma cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Off-target effects of plasmid-transcribed shRNAs on NFκB signaling pathway and cell survival of human melanoma cells.
38741,67910,24204712,10.1371/journal.pone.0076954,offtarget,siRNA,PMC full text high-precision preselection,seed;sirna,"full-text off-target candidate; title/source terms=seed, sirna; source title: The transition from primary siRNAs to amplified secondary siRNAs that regulate chalcone synthase during development of Glycine max seed coats.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The transition from primary siRNAs to amplified secondary siRNAs that regulate chalcone synthase during development of Glycine max seed coats.
38742,67911,23665227,10.1016/j.molcel.2013.04.007,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;rnai,"full-text off-target candidate; title/source terms=transcriptome, rnai; source title: A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway.
38743,67912,23325850,10.1093/nar/gks1474,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues.
38744,67913,23620279,10.1093/nar/gkt200,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants.
38745,67914,23484018,10.1371/journal.pone.0058326,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Whole-genome thermodynamic analysis reduces siRNA off-target effects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Whole-genome thermodynamic analysis reduces siRNA off-target effects.
38746,67915,22773071,10.1007/s10493-012-9598-x,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Gene silencing in tick cell lines using small interfering or long double-stranded RNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gene silencing in tick cell lines using small interfering or long double-stranded RNA.
38747,67916,23749575,10.1007/978-1-62703-468-5_11,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Single-walled carbon nanotube-mediated small interfering RNA delivery for gastrin-releasing peptide receptor silencing in human neuroblastoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Single-walled carbon nanotube-mediated small interfering RNA delivery for gastrin-releasing peptide receptor silencing in human neuroblastoma.
38748,67917,23629666,10.3390/ijms14059305,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Off-target effect of endogenous siRNA derived from RMRP in human cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Off-target effect of endogenous siRNA derived from RMRP in human cells.
38749,67918,23542151,10.1104/pp.113.216481,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: The initiation of epigenetic silencing of active transposable elements is triggered by RDR6 and 21-22 nucleotide small interfering RNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The initiation of epigenetic silencing of active transposable elements is triggered by RDR6 and 21-22 nucleotide small interfering RNAs.
38750,67919,24278423,10.1371/journal.pone.0081326,offtarget,siRNA,PMC full text high-precision preselection,mismatch;sirna,"full-text off-target candidate; title/source terms=mismatch, sirna; source title: An attempt to detect siRNA-mediated genomic DNA modification by artificially induced mismatch siRNA in Arabidopsis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,An attempt to detect siRNA-mediated genomic DNA modification by artificially induced mismatch siRNA in Arabidopsis.
38751,67920,23569377,10.2147/IJN.S41555,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: A novel dendritic nanocarrier of polyamidoamine-polyethylene glycol-cyclic RGD for ""smart"" small interfering RNA delivery and in vitro antitumor effects by human ether-à-go-go-related gene silencing in anaplastic thyroid carcinoma cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"A novel dendritic nanocarrier of polyamidoamine-polyethylene glycol-cyclic RGD for ""smart"" small interfering RNA delivery and in vitro antitumor effects by human ether-à-go-go-related gene silencing in anaplastic thyroid carcinoma cells."
38752,67921,23935115,10.1093/nar/gkt693,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy.
38753,67922,23766646,10.2147/IJN.S42440,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Low-weight polyethylenimine cross-linked 2-hydroxypopyl-β-cyclodextrin and folic acid as an efficient and nontoxic siRNA carrier for gene silencing and tumor inhibition by VEGF siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Low-weight polyethylenimine cross-linked 2-hydroxypopyl-β-cyclodextrin and folic acid as an efficient and nontoxic siRNA carrier for gene silencing and tumor inhibition by VEGF siRNA.
38754,67923,23511973,10.1038/emboj.2013.52,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing.
38755,67924,23233254,10.1167/iovs.12-10528,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Allele-specific siRNA silencing for the common keratin 12 founder mutation in Meesmann epithelial corneal dystrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Allele-specific siRNA silencing for the common keratin 12 founder mutation in Meesmann epithelial corneal dystrophy.
38756,67925,23363624,10.1101/gr.149112.112,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes."
38757,67926,23356234,10.1186/1477-7819-11-22,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells.
38758,67927,23686579,10.1073/pnas.1219655110,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Warm temperatures induce transgenerational epigenetic release of RNA silencing by inhibiting siRNA biogenesis in Arabidopsis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Warm temperatures induce transgenerational epigenetic release of RNA silencing by inhibiting siRNA biogenesis in Arabidopsis.
38759,67928,23441235,10.1371/journal.pone.0057140,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Computational analysis of siRNA recognition by the Ago2 PAZ domain and identification of the determinants of RNA-induced gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Computational analysis of siRNA recognition by the Ago2 PAZ domain and identification of the determinants of RNA-induced gene silencing.
38760,67929,23823756,10.1371/journal.pone.0065931,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;rnai,"full-text off-target candidate; title/source terms=transcriptome, rnai; source title: Transcriptome Analysis and Screening for Potential Target Genes for RNAi-Mediated Pest Control of the Beet Armyworm, Spodoptera exigua.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Transcriptome Analysis and Screening for Potential Target Genes for RNAi-Mediated Pest Control of the Beet Armyworm, Spodoptera exigua."
38761,67930,23900224,10.1038/mtna.2013.29,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Combination of siRNA-directed Gene Silencing With Cisplatin Reverses Drug Resistance in Human Non-small Cell Lung Cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Combination of siRNA-directed Gene Silencing With Cisplatin Reverses Drug Resistance in Human Non-small Cell Lung Cancer.
38762,67931,23445545,10.1186/1756-0500-6-72,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: The illusion of specific capture: surface and solution studies of suboptimal oligonucleotide hybridization.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The illusion of specific capture: surface and solution studies of suboptimal oligonucleotide hybridization.
38763,67932,22645644,10.1038/srep00428,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: siRNA off-target effects in genome-wide screens identify signaling pathway members.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA off-target effects in genome-wide screens identify signaling pathway members.
38764,67933,23259405,10.1186/1471-2164-13-721,offtarget,ASO,PMC full text high-precision preselection,rna-seq;antisense,"full-text off-target candidate; title/source terms=rna-seq, antisense; source title: Strand-specific RNA-seq reveals widespread occurrence of novel cis-natural antisense transcripts in rice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Strand-specific RNA-seq reveals widespread occurrence of novel cis-natural antisense transcripts in rice.
38765,67934,22431617,10.1073/pnas.1203094109,offtarget,siRNA,PMC full text high-precision preselection,seed;sirna,"full-text off-target candidate; title/source terms=seed, sirna; source title: Maternal siRNAs as regulators of parental genome imbalance and gene expression in endosperm of Arabidopsis seeds.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Maternal siRNAs as regulators of parental genome imbalance and gene expression in endosperm of Arabidopsis seeds.
38766,67935,23145149,10.1371/journal.pone.0049309,offtarget,siRNA,PMC full text high-precision preselection,mismatch;sirna,"full-text off-target candidate; title/source terms=mismatch, sirna; source title: siRNA has greatly elevated mismatch tolerance at 3'-UTR sites.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,siRNA has greatly elevated mismatch tolerance at 3'-UTR sites.
38767,67936,22064859,10.1093/nar/gkr891,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Direct evidence of nuclear Argonaute distribution during transcriptional silencing links the actin cytoskeleton to nuclear RNAi machinery in human cells.
38768,67937,23251657,10.1371/journal.pone.0051942,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: C911: A bench-level control for sequence specific siRNA off-target effects.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,C911: A bench-level control for sequence specific siRNA off-target effects.
38769,67938,22983148,10.3390/molecules170911089,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Enhancement of gene silencing effect and membrane permeability by Peptide-conjugated 27-nucleotide small interfering RNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhancement of gene silencing effect and membrane permeability by Peptide-conjugated 27-nucleotide small interfering RNA.
38770,67939,22475061,10.1021/ja300174v,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Reductively responsive siRNA-conjugated hydrogel nanoparticles for gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Reductively responsive siRNA-conjugated hydrogel nanoparticles for gene silencing.
38771,67940,22827812,10.1186/1472-6750-12-42,offtarget,siRNA,PMC full text high-precision preselection,mirna;shrna,"full-text off-target candidate; title/source terms=mirna, shrna; source title: Optimization and comparison of knockdown efficacy between polymerase II expressed shRNA and artificial miRNA targeting luciferase and Apolipoprotein B100.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Optimization and comparison of knockdown efficacy between polymerase II expressed shRNA and artificial miRNA targeting luciferase and Apolipoprotein B100.
38772,67941,23030736,10.1021/ja307102g,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding.
38773,67942,23141545,10.1016/j.cell.2012.09.042,offtarget,siRNA,PMC full text high-precision preselection,mirna;shrna,"full-text off-target candidate; title/source terms=mirna, shrna; source title: The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo.
38774,67943,22888847,10.1089/hum.2012.078,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: AAV-based RNAi silencing of NADPH oxidase gp91(phox) attenuates cold-induced cardiovascular dysfunction.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,AAV-based RNAi silencing of NADPH oxidase gp91(phox) attenuates cold-induced cardiovascular dysfunction.
38775,67944,22701315,10.2147/IJN.S30500,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs.
38776,67945,22704043,10.1186/gb-2012-13-6-r47,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Apple miRNAs and tasiRNAs with novel regulatory networks.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Apple miRNAs and tasiRNAs with novel regulatory networks.
38777,67946,22895695,10.3892/or.2012.1963,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNA-mediated silencing of integrin β3 expression inhibits the metastatic potential of B16 melanoma cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA-mediated silencing of integrin β3 expression inhibits the metastatic potential of B16 melanoma cells.
38778,67947,22810205,10.1093/nar/gks662,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing.
38779,67948,23074025,10.1002/anie.201206595,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: A bioreducible polymer for efficient delivery of Fas-silencing siRNA into stem cell spheroids and enhanced therapeutic angiogenesis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A bioreducible polymer for efficient delivery of Fas-silencing siRNA into stem cell spheroids and enhanced therapeutic angiogenesis.
38780,67949,22988120,10.1073/pnas.1214094109,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNA silencing of estrogen receptor-α expression specifically in medial preoptic area neurons abolishes maternal care in female mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA silencing of estrogen receptor-α expression specifically in medial preoptic area neurons abolishes maternal care in female mice.
38781,67950,22080508,10.1093/nar/gkr1002,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group.
38782,67951,22216762,10.1186/1476-4598-11-1,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;rnai,"full-text off-target candidate; title/source terms=transcriptome, rnai; source title: Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.
38783,67952,22694849,10.1186/1471-2180-12-107,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,"In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway."
38784,67953,22343343,10.1038/nmeth.1898,offtarget,siRNA,PMC full text high-precision preselection,off-target;rnai,"full-text off-target candidate; title/source terms=off-target, rnai; source title: A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens.
38785,67954,23028290,10.1371/journal.pcbi.1002693,offtarget,siRNA,PMC full text high-precision preselection,mismatch;rnai,"full-text off-target candidate; title/source terms=mismatch, rnai; source title: Convergent transmission of RNAi guide-target mismatch information across Argonaute internal allosteric network.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Convergent transmission of RNAi guide-target mismatch information across Argonaute internal allosteric network.
38786,67955,22814456,10.1128/JCM.00976-12,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: ""Spoligoriftyping,"" a dual-priming-oligonucleotide-based direct-hybridization assay for tuberculosis control with a multianalyte microbead-based hybridization system.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"""Spoligoriftyping,"" a dual-priming-oligonucleotide-based direct-hybridization assay for tuberculosis control with a multianalyte microbead-based hybridization system."
38787,67956,22386491,10.1016/j.bios.2011.12.055,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mismatch;oligonucleotide,"full-text off-target candidate; title/source terms=mismatch, oligonucleotide; source title: Visual detection of single-base mismatches in DNA using hairpin oligonucleotide with double-target DNA binding sequences and gold nanoparticles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Visual detection of single-base mismatches in DNA using hairpin oligonucleotide with double-target DNA binding sequences and gold nanoparticles.
38788,67957,22174890,10.1371/journal.pone.0028753,offtarget,siRNA,PMC full text high-precision preselection,off-target;rnai,"full-text off-target candidate; title/source terms=off-target, rnai; source title: An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.
38789,67958,21750714,10.1371/journal.pone.0021503,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: siRNA off-target effects can be reduced at concentrations that match their individual potency.",B,high_candidate,curator_rejected,reject,derived_annotations_only,siRNA off-target effects can be reduced at concentrations that match their individual potency.
38790,67959,21749289,10.1089/nat.2011.0286,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Structural diversity repertoire of gene silencing small interfering RNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structural diversity repertoire of gene silencing small interfering RNAs.
38791,67960,21443765,10.1186/1471-2164-12-162,offtarget,siRNA,PMC full text high-precision preselection,microarray;sirna,"full-text off-target candidate; title/source terms=microarray, sirna; source title: A cell spot microarray method for production of high density siRNA transfection microarrays.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A cell spot microarray method for production of high density siRNA transfection microarrays.
38792,67961,21437668,10.1007/s12031-011-9514-6,offtarget,siRNA,PMC full text high-precision preselection,specificity;sirna,"full-text off-target candidate; title/source terms=specificity, sirna; source title: Screening target specificity of siRNAs by rapid amplification of cDNA ends (RACE) for non-sequenced species.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Screening target specificity of siRNAs by rapid amplification of cDNA ends (RACE) for non-sequenced species.
38793,67962,21367974,10.1261/rna.2348111,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects.
38794,67963,22106253,10.1073/pnas.1113310108,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans.
38795,67964,21629223,10.1038/mt.2011.104,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Anti-CD22 antibody targeting of pH-responsive micelles enhances small interfering RNA delivery and gene silencing in lymphoma cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Anti-CD22 antibody targeting of pH-responsive micelles enhances small interfering RNA delivery and gene silencing in lymphoma cells.
38796,67965,21971424,10.1038/mt.2011.190,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.
38797,67966,21936502,10.1021/nn202772p,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNA-aptamer chimeras on nanoparticles: preserving targeting functionality for effective gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA-aptamer chimeras on nanoparticles: preserving targeting functionality for effective gene silencing.
38798,67967,21818135,10.1038/cgt.2011.40,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Selective modification of HK peptides enhances siRNA silencing of tumor targets in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Selective modification of HK peptides enhances siRNA silencing of tumor targets in vivo.
38799,67968,21779345,10.1371/journal.pone.0021882,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Both piRNA and siRNA pathways are silencing transcripts of the suffix element in the Drosophila melanogaster germline and somatic cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Both piRNA and siRNA pathways are silencing transcripts of the suffix element in the Drosophila melanogaster germline and somatic cells.
38800,67969,21347381,10.1371/journal.pone.0016895,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Graft-transmitted siRNA signal from the root induces visual manifestation of endogenous post-transcriptional gene silencing in the scion.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Graft-transmitted siRNA signal from the root induces visual manifestation of endogenous post-transcriptional gene silencing in the scion.
38801,67970,21294265,10.1002/smll.201001314,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Effective gene silencing by multilayered siRNA-coated gold nanoparticles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effective gene silencing by multilayered siRNA-coated gold nanoparticles.
38802,67971,21181546,10.1007/s11095-010-0344-y,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Disulfide-based poly(amido amine)s for siRNA delivery: effects of structure on siRNA complexation, cellular uptake, gene silencing and toxicity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Disulfide-based poly(amido amine)s for siRNA delivery: effects of structure on siRNA complexation, cellular uptake, gene silencing and toxicity."
38803,67972,21813456,10.1093/nar/gkr590,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: The miRNA pathway limits AGO1 availability during siRNA-mediated PTGS defense against exogenous RNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The miRNA pathway limits AGO1 availability during siRNA-mediated PTGS defense against exogenous RNA.
38804,67973,22049083,10.1074/jbc.M111.278184,offtarget,ASO,PMC full text high-precision preselection,silencing;antisense,"full-text off-target candidate; title/source terms=silencing, antisense; source title: Nucleus-localized antisense small RNAs with 5'-polyphosphate termini regulate long term transcriptional gene silencing in Entamoeba histolytica G3 strain.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Nucleus-localized antisense small RNAs with 5'-polyphosphate termini regulate long term transcriptional gene silencing in Entamoeba histolytica G3 strain.
38805,67974,21134910,10.1093/nar/gkq1240,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Comparative analysis of non-autonomous effects of tasiRNAs and miRNAs in Arabidopsis thaliana.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comparative analysis of non-autonomous effects of tasiRNAs and miRNAs in Arabidopsis thaliana.
38806,67975,21750531,10.1038/mt.2011.141,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery.
38807,67976,21765961,10.1371/journal.pntd.0001212,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Polyethyleneimine (PEI) mediated siRNA gene silencing in the Schistosoma mansoni snail host, Biomphalaria glabrata.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Polyethyleneimine (PEI) mediated siRNA gene silencing in the Schistosoma mansoni snail host, Biomphalaria glabrata."
38808,67977,21401928,10.1186/1758-907X-2-3,offtarget,siRNA,PMC full text high-precision preselection,off-target;rnai,"full-text off-target candidate; title/source terms=off-target, rnai; source title: Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2.
38809,67978,21780311,10.1002/adma.201101401,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Multiplexed magnetic labeling amplification using oligonucleotide hybridization.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Multiplexed magnetic labeling amplification using oligonucleotide hybridization.
38810,67979,21966380,10.1371/journal.pone.0024906,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Microarray generation of thousand-member oligonucleotide libraries.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Microarray generation of thousand-member oligonucleotide libraries.
38811,67980,21127932,10.1007/s10126-010-9335-6,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Development and experimental validation of a 20K Atlantic cod (Gadus morhua) oligonucleotide microarray based on a collection of over 150,000 ESTs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Development and experimental validation of a 20K Atlantic cod (Gadus morhua) oligonucleotide microarray based on a collection of over 150,000 ESTs."
38812,67981,21687525,10.4161/adna.1.1.12204,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts.
38813,67982,20453030,10.1093/nar/gkq341,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
38814,67983,20230625,10.1186/1471-2164-11-175,offtarget,siRNA,PMC full text high-precision preselection,off-target;rnai,"full-text off-target candidate; title/source terms=off-target, rnai; source title: Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis.
38815,67984,21028803,10.1021/ja1059763,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Highly efficient gene silencing activity of siRNA embedded in a nanostructured gyroid cubic lipid matrix.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Highly efficient gene silencing activity of siRNA embedded in a nanostructured gyroid cubic lipid matrix.
38816,67985,20062003,10.1038/embor.2009.273,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast.
38817,67986,19997090,10.1038/mt.2009.271,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice.
38818,67987,20571543,10.1038/mt.2010.126,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Silencing of reporter gene expression in skin using siRNAs and expression of plasmid DNA delivered by a soluble protrusion array device (PAD).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing of reporter gene expression in skin using siRNAs and expression of plasmid DNA delivered by a soluble protrusion array device (PAD).
38819,67988,20515078,10.1021/bi1002376,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: From gene delivery to gene silencing: plasmid DNA-transfecting cationic lipid 1,3-dimyristoylamidopropane-2-[bis(2-dimethylaminoethane)] carbamate efficiently promotes small interfering RNA-induced RNA interference.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"From gene delivery to gene silencing: plasmid DNA-transfecting cationic lipid 1,3-dimyristoylamidopropane-2-[bis(2-dimethylaminoethane)] carbamate efficiently promotes small interfering RNA-induced RNA interference."
38820,67989,21070421,10.1111/j.1365-313X.2010.04358.x,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Transcriptional silencing induced by Arabidopsis T-DNA mutants is associated with 35S promoter siRNAs and requires genes involved in siRNA-mediated chromatin silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transcriptional silencing induced by Arabidopsis T-DNA mutants is associated with 35S promoter siRNAs and requires genes involved in siRNA-mediated chromatin silencing.
38821,67990,20707386,10.1021/nn101638u,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte.
38822,67991,20551436,10.1534/genetics.110.118273,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: QIP, a protein that converts duplex siRNA into single strands, is required for meiotic silencing by unpaired DNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"QIP, a protein that converts duplex siRNA into single strands, is required for meiotic silencing by unpaired DNA."
38823,67992,20801607,10.1016/j.jvs.2010.06.169,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Endothelial cells are susceptible to rapid siRNA transfection and gene silencing ex vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Endothelial cells are susceptible to rapid siRNA transfection and gene silencing ex vivo.
38824,67993,20722417,10.1021/mp100221h,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: pH-Sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,pH-Sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells.
38825,67994,20863366,10.1186/bcr2644,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Silencing of the IKKε gene by siRNA inhibits invasiveness and growth of breast cancer cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing of the IKKε gene by siRNA inhibits invasiveness and growth of breast cancer cells.
38826,67995,19930157,10.1111/j.1349-7006.2009.01417.x,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Effect of siRNA-mediated silencing of Bmi-1 gene expression on HeLa cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of siRNA-mediated silencing of Bmi-1 gene expression on HeLa cells.
38827,67996,20360048,10.1093/nar/gkq206,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing.
38828,67997,19904549,10.1007/s00412-009-0244-2,offtarget,siRNA,PMC full text high-precision preselection,specificity;sirna,"full-text off-target candidate; title/source terms=specificity, sirna; source title: Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.
38829,67998,20957038,10.1371/journal.pone.0013119,offtarget,siRNA,PMC full text high-precision preselection,off-target;rnai,"full-text off-target candidate; title/source terms=off-target, rnai; source title: RNAi experiments in D. melanogaster: solutions to the overlooked problem of off-targets shared by independent dsRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi experiments in D. melanogaster: solutions to the overlooked problem of off-targets shared by independent dsRNAs.
38830,67999,21170345,10.1371/journal.pone.0014266,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,transcriptome;oligonucleotide,"full-text off-target candidate; title/source terms=transcriptome, oligonucleotide; source title: Design, validation and annotation of transcriptome-wide oligonucleotide probes for the oligochaete annelid Eisenia fetida.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Design, validation and annotation of transcriptome-wide oligonucleotide probes for the oligochaete annelid Eisenia fetida."
38831,68000,20086052,10.1261/rna.1775610,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Whole mount in situ hybridization detection of mRNAs using short LNA containing DNA oligonucleotide probes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Whole mount in situ hybridization detection of mRNAs using short LNA containing DNA oligonucleotide probes.
38832,68001,20688976,10.1093/bioinformatics/btq431,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: A framework for oligonucleotide microarray preprocessing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A framework for oligonucleotide microarray preprocessing.
38833,68002,22163607,10.3390/s100807371,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Use of a multiplexed CMOS microarray to optimize and compare oligonucleotide binding to DNA probes synthesized or immobilized on individual electrodes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Use of a multiplexed CMOS microarray to optimize and compare oligonucleotide binding to DNA probes synthesized or immobilized on individual electrodes.
38834,68003,20360838,10.1371/journal.pone.0009762,offtarget,ASO,PMC full text high-precision preselection,transcriptome;antisense,"full-text off-target candidate; title/source terms=transcriptome, antisense; source title: In-depth transcriptome analysis reveals novel TARs and prevalent antisense transcription in human cell lines.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In-depth transcriptome analysis reveals novel TARs and prevalent antisense transcription in human cell lines.
38835,68004,19144911,10.1261/rna.1326809,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: MicroRNA-like off-target transcript regulation by siRNAs is species specific.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MicroRNA-like off-target transcript regulation by siRNAs is species specific.
38836,68005,19403062,10.1038/cmi.2009.17,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: CTLA4 silencing with siRNA promotes deviation of Th1/Th2 in chronic hepatitis B patients.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CTLA4 silencing with siRNA promotes deviation of Th1/Th2 in chronic hepatitis B patients.
38837,68006,19767612,10.1093/nar/gkp735,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.
38838,68007,19846596,10.1093/nar/gkp864,offtarget,siRNA,PMC full text high-precision preselection,specificity;sirna,"full-text off-target candidate; title/source terms=specificity, sirna; source title: Selection of hyperfunctional siRNAs with improved potency and specificity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Selection of hyperfunctional siRNAs with improved potency and specificity.
38839,68008,19156133,10.1038/mt.2008.298,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects.
38840,68009,19347041,10.1371/journal.pone.0005028,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-mediated c-Rel silencing leads to apoptosis of B cell tumor cells and suppresses antigenic immune response in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,RNAi-mediated c-Rel silencing leads to apoptosis of B cell tumor cells and suppresses antigenic immune response in vivo.
38841,68010,19889219,10.1186/gb-2009-10-11-r122,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: Genome-wide analysis reveals rapid and dynamic changes in miRNA and siRNA sequence and expression during ovule and fiber development in allotetraploid cotton (Gossypium hirsutum L.).",B,high_candidate,curator_rejected,reject,derived_annotations_only,Genome-wide analysis reveals rapid and dynamic changes in miRNA and siRNA sequence and expression during ovule and fiber development in allotetraploid cotton (Gossypium hirsutum L.).
38842,68011,19401777,10.1371/journal.pone.0005382,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells.
38843,68012,19119310,10.1371/journal.pone.0004110,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Metal A and metal B sites of nuclear RNA polymerases Pol IV and Pol V are required for siRNA-dependent DNA methylation and gene silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Metal A and metal B sites of nuclear RNA polymerases Pol IV and Pol V are required for siRNA-dependent DNA methylation and gene silencing.
38844,68013,19461583,10.1038/emboj.2009.139,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells.
38845,68014,19389425,10.1016/j.plasmid.2009.04.001,offtarget,siRNA,PMC full text high-precision preselection,silencing;shrna,"full-text off-target candidate; title/source terms=silencing, shrna; source title: A novel short hairpin RNA (shRNA) expression system promotes Sox9-dependent gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A novel short hairpin RNA (shRNA) expression system promotes Sox9-dependent gene silencing.
38846,68015,18940242,10.1016/j.ijpharm.2008.09.039,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Polymeric nanoparticles for siRNA delivery and gene silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Polymeric nanoparticles for siRNA delivery and gene silencing.
38847,68016,19815517,10.1073/pnas.0904721106,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Uncovering pathways in DNA oligonucleotide hybridization via transition state analysis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Uncovering pathways in DNA oligonucleotide hybridization via transition state analysis.
38848,68017,19758430,10.1186/1471-2164-10-436,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Heterologous oligonucleotide microarrays for transcriptomics in a non-model species; a proof-of-concept study of drought stress in Musa.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Heterologous oligonucleotide microarrays for transcriptomics in a non-model species; a proof-of-concept study of drought stress in Musa.
38849,68018,18978784,10.1038/nmeth.1267,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Detecting microRNA binding and siRNA off-target effects from expression data.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Detecting microRNA binding and siRNA off-target effects from expression data.
38850,68019,18577207,10.1186/1471-2199-9-60,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Off-target effects of siRNA specific for GFP.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Off-target effects of siRNA specific for GFP.
38851,68020,18367449,10.1074/jbc.M800834200,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression.
38852,68021,18073195,10.1093/nar/gkm920,offtarget,siRNA,PMC full text high-precision preselection,hybridization;sirna,"full-text off-target candidate; title/source terms=hybridization, sirna; source title: Efficient siRNA selection using hybridization thermodynamics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient siRNA selection using hybridization thermodynamics.
38853,68022,18490376,10.1093/nar/gkn250,offtarget,siRNA,PMC full text high-precision preselection,hybridization;sirna,"full-text off-target candidate; title/source terms=hybridization, sirna; source title: OligoWalk: an online siRNA design tool utilizing hybridization thermodynamics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,OligoWalk: an online siRNA design tool utilizing hybridization thermodynamics.
38854,68023,18367718,10.1261/rna.901908,offtarget,siRNA,PMC full text high-precision preselection,specificity;rnai,"full-text off-target candidate; title/source terms=specificity, rnai; source title: Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans.
38855,68024,18948543,10.1126/science.1164029,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Splicing factors facilitate RNAi-directed silencing in fission yeast.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Splicing factors facilitate RNAi-directed silencing in fission yeast.
38856,68025,19061642,10.1016/j.molcel.2008.11.009,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Multimegabase silencing in nucleolar dominance involves siRNA-directed DNA methylation and specific methylcytosine-binding proteins.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Multimegabase silencing in nucleolar dominance involves siRNA-directed DNA methylation and specific methylcytosine-binding proteins.
38857,68026,18096615,10.1093/nar/gkm630,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect.
38858,68027,18094121,10.1261/rna.789808,offtarget,siRNA,PMC full text high-precision preselection,specificity;sirna,"full-text off-target candidate; title/source terms=specificity, sirna; source title: Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity.
38859,68028,18306428,10.1002/bit.21798,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Impact of target mRNA structure on siRNA silencing efficiency: A large-scale study.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Impact of target mRNA structure on siRNA silencing efficiency: A large-scale study.
38860,68029,18441221,10.1104/pp.108.118307,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Artificial trans-acting siRNAs confer consistent and effective gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Artificial trans-acting siRNAs confer consistent and effective gene silencing.
38861,68030,18388916,10.1038/mt.2008.51,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA.
38862,68031,18794145,10.1158/0008-5472.CAN-08-0632,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.
38863,68032,18166484,10.1016/j.nbd.2007.11.003,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo.
38864,68033,18719398,10.4161/epi.3.4.6631,offtarget,siRNA,PMC full text high-precision preselection,transcriptome;rnai,"full-text off-target candidate; title/source terms=transcriptome, rnai; source title: Maize lines expressing RNAi to chromatin remodeling factors are similarly hypersensitive to UV-B radiation but exhibit distinct transcriptome responses.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Maize lines expressing RNAi to chromatin remodeling factors are similarly hypersensitive to UV-B radiation but exhibit distinct transcriptome responses.
38865,68034,18637729,10.1089/oli.2008.0120,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mismatch;oligonucleotide,"full-text off-target candidate; title/source terms=mismatch, oligonucleotide; source title: Oligonucleotide-mediated gene targeting in human hepatocytes: implications of mismatch repair.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oligonucleotide-mediated gene targeting in human hepatocytes: implications of mismatch repair.
38866,68035,18442196,10.3748/wjg.14.2501,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: detection by oligonucleotide microarray and real-time PCR analysis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: detection by oligonucleotide microarray and real-time PCR analysis.
38867,68036,18547420,10.1186/1471-2164-9-278,offtarget,siRNA,PMC full text high-precision preselection,microarray;rnai,"full-text off-target candidate; title/source terms=microarray, rnai; source title: Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins.
38868,68037,17445269,10.1186/1471-2164-8-106,offtarget,siRNA,PMC full text high-precision preselection,off-target;rnai,"full-text off-target candidate; title/source terms=off-target, rnai; source title: Novel insights into RNAi off-target effects using C. elegans paralogs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Novel insights into RNAi off-target effects using C. elegans paralogs.
38869,68038,17596515,10.1091/mbc.e07-01-0070,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodies.
38870,68039,17135323,10.1128/JVI.01980-06,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: A novel repeat-associated small interfering RNA-mediated silencing pathway downregulates complementary sense gypsy transcripts in somatic cells of the Drosophila ovary.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A novel repeat-associated small interfering RNA-mediated silencing pathway downregulates complementary sense gypsy transcripts in somatic cells of the Drosophila ovary.
38871,68040,17169992,10.1093/nar/gkl1065,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signature.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signature.
38872,68041,17604308,10.1093/nar/gkm491,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: GW body disassembly triggered by siRNAs independently of their silencing activity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,GW body disassembly triggered by siRNAs independently of their silencing activity.
38873,68042,17389931,10.7150/ijbs.3.242,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.
38874,68043,17237357,10.1261/rna.352507,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Comparison of siRNA-induced off-target RNA and protein effects.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Comparison of siRNA-induced off-target RNA and protein effects.
38875,68044,17913877,10.1073/pnas.0707831104,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Sticky overhangs enhance siRNA-mediated gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Sticky overhangs enhance siRNA-mediated gene silencing.
38876,68045,17940007,10.1073/pnas.0708285104,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.
38877,68046,17534426,10.1371/journal.pone.0000476,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Suffix-specific RNAi leads to silencing of F element in Drosophila melanogaster.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Suffix-specific RNAi leads to silencing of F element in Drosophila melanogaster.
38878,68047,17244361,10.1186/1471-2164-8-28,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: High-density rhesus macaque oligonucleotide microarray design using early-stage rhesus genome sequence information and human genome annotations.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-density rhesus macaque oligonucleotide microarray design using early-stage rhesus genome sequence information and human genome annotations.
38879,68048,17496028,10.1529/biophysj.106.103275,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Kinetics of oligonucleotide hybridization to DNA probe arrays on high-capacity porous silica substrates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Kinetics of oligonucleotide hybridization to DNA probe arrays on high-capacity porous silica substrates.
38880,68049,17251336,10.2353/jmoldx.2007.060072,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Development and applications of a BRAF oligonucleotide microarray.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Development and applications of a BRAF oligonucleotide microarray.
38881,68050,17389046,10.1186/1471-2164-8-81,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Spotted cotton oligonucleotide microarrays for gene expression analysis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Spotted cotton oligonucleotide microarrays for gene expression analysis.
38882,68051,16682561,10.1261/rna.28106,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Off-target effects by siRNA can induce toxic phenotype.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Off-target effects by siRNA can induce toxic phenotype.
38883,68052,17187675,10.1186/1472-6750-6-50,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencing.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencing.
38884,68053,16717282,10.1093/nar/gkl339,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: High potency silencing by single-stranded boranophosphate siRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,High potency silencing by single-stranded boranophosphate siRNA.
38885,68054,16410612,10.1093/nar/gkj439,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging.
38886,68055,16466716,10.1016/j.exer.2005.12.003,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: The effect of temperature on gene silencing by siRNAs: implications for silencing in the anterior chamber of the eye.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The effect of temperature on gene silencing by siRNAs: implications for silencing in the anterior chamber of the eye.
38887,68056,19771225,,offtarget,siRNA,PMC full text high-precision preselection,off-target;sirna,"full-text off-target candidate; title/source terms=off-target, sirna; source title: Minimizing off-target effects by using diced siRNAs for RNA interference.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Minimizing off-target effects by using diced siRNAs for RNA interference.
38888,68057,16844783,10.1073/pnas.0602984103,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens.
38889,68058,17071713,10.1093/nar/gkl719,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,mismatch;oligonucleotide,"full-text off-target candidate; title/source terms=mismatch, oligonucleotide; source title: pH-Dependent mismatch discrimination of oligonucleotide duplexes containing 2'-deoxytubercidin and 2- or 7-substituted derivatives: protonated base pairs formed between 7-deazapurines and cytosine.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,pH-Dependent mismatch discrimination of oligonucleotide duplexes containing 2'-deoxytubercidin and 2- or 7-substituted derivatives: protonated base pairs formed between 7-deazapurines and cytosine.
38890,68059,16776839,10.1186/1471-2164-7-153,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Identical probes on different high-density oligonucleotide microarrays can produce different measurements of gene expression.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identical probes on different high-density oligonucleotide microarrays can produce different measurements of gene expression.
38891,68060,16542496,10.1186/gb-2006-7-3-r22,offtarget,ASO,PMC full text high-precision preselection,transcriptome;antisense,"full-text off-target candidate; title/source terms=transcriptome, antisense; source title: Comparative profiling of the sense and antisense transcriptome of maize lines.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Comparative profiling of the sense and antisense transcriptome of maize lines.
38892,68061,16113241,10.1093/nar/gki785,offtarget,siRNA,PMC full text high-precision preselection,specificity;sirna,"full-text off-target candidate; title/source terms=specificity, sirna; source title: Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo."
38893,68062,16204182,10.1101/gad.344205,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing.
38894,68063,15831483,10.1128/MCB.25.9.3793-3801.2005,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Small interfering RNAs that trigger posttranscriptional gene silencing are not required for the histone H3 Lys9 methylation necessary for transgenic tandem repeat stabilization in Neurospora crassa.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Small interfering RNAs that trigger posttranscriptional gene silencing are not required for the histone H3 Lys9 methylation necessary for transgenic tandem repeat stabilization in Neurospora crassa.
38895,68064,16352864,10.1093/nar/gni188,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Quantum dots to monitor RNAi delivery and improve gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Quantum dots to monitor RNAi delivery and improve gene silencing.
38896,68065,16314933,10.1007/s00018-005-5182-4,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNA-mediated transcriptional gene silencing: the potential mechanism and a possible role in the histone code.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA-mediated transcriptional gene silencing: the potential mechanism and a possible role in the histone code.
38897,68066,16099798,10.1136/gut.2004.056192,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer.
38898,68067,16282589,10.1093/nar/gki952,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi.
38899,68068,15678169,10.1251/bpo99,offtarget,siRNA,PMC full text high-precision preselection,specificity;sirna,"full-text off-target candidate; title/source terms=specificity, sirna; source title: A rapid and sensitive assay for quantification of siRNA efficiency and specificity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A rapid and sensitive assay for quantification of siRNA efficiency and specificity.
38900,68069,15854232,10.1186/1471-2164-6-59,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Gene expression levels assessed by oligonucleotide microarray analysis and quantitative real-time RT-PCR -- how well do they correlate?",B,high_candidate,curator_rejected,reject,derived_annotations_only,Gene expression levels assessed by oligonucleotide microarray analysis and quantitative real-time RT-PCR -- how well do they correlate?
38901,68070,15799785,10.1186/1471-2105-6-80,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Correlation test to assess low-level processing of high-density oligonucleotide microarray data.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Correlation test to assess low-level processing of high-density oligonucleotide microarray data.
38902,68071,15718294,10.1093/nar/gni024,offtarget,ASO,PMC full text high-precision preselection,hybridization;antisense,"full-text off-target candidate; title/source terms=hybridization, antisense; source title: Identification of antisense nucleic acid hybridization sites in mRNA molecules with self-quenching fluorescent reporter molecules.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identification of antisense nucleic acid hybridization sites in mRNA molecules with self-quenching fluorescent reporter molecules.
38903,68072,15613536,10.1261/rna.7180305,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Efficient fluorescence labeling of a large RNA through oligonucleotide hybridization.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient fluorescence labeling of a large RNA through oligonucleotide hybridization.
38904,68073,16332846,10.1128/AEM.71.12.8548-8557.2005,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Waterborne pathogen detection by use of oligonucleotide-based microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Waterborne pathogen detection by use of oligonucleotide-based microarrays.
38905,68074,15272085,10.1093/nar/gkh714,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNA-mediated gene silencing: a global genome view.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNA-mediated gene silencing: a global genome view.
38906,68075,15383794,10.1097/01.sla.0000140755.97224.9a,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer.
38907,68076,14993466,10.1093/nar/gkh314,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Efficient RNA interference depends on global context of the target sequence: quantitative analysis of silencing efficiency using Eulerian graph representation of siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Efficient RNA interference depends on global context of the target sequence: quantitative analysis of silencing efficiency using Eulerian graph representation of siRNA.
38908,68077,15272050,10.1093/nar/gnh093,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo.
38909,68078,15504339,10.1016/j.bbrc.2004.09.180,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Silencing of SARS-CoV spike gene by small interfering RNA in HEK 293T cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Silencing of SARS-CoV spike gene by small interfering RNA in HEK 293T cells.
38910,68079,14966264,10.1093/nar/gkh278,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins.
38911,68080,15302921,10.1093/nar/gkh764,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: RNAi-dependent and RNAi-independent mechanisms contribute to the silencing of RIPed sequences in Neurospora crassa.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi-dependent and RNAi-independent mechanisms contribute to the silencing of RIPed sequences in Neurospora crassa.
38912,68081,14769947,10.1093/nar/gkh238,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens.
38913,68082,14970398,10.1261/rna.5235104,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.
38914,68083,15720805,10.1593/neo.04313,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Silencing of the HER2/neu gene by siRNA inhibits proliferation and induces apoptosis in HER2/neu-overexpressing breast cancer cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Silencing of the HER2/neu gene by siRNA inhibits proliferation and induces apoptosis in HER2/neu-overexpressing breast cancer cells.
38915,68084,15107483,10.1093/nar/gnh057,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Attachment of oligonucleotide probes to poly carbodiimide-coated glass for microarray applications.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Attachment of oligonucleotide probes to poly carbodiimide-coated glass for microarray applications.
38916,68085,15483344,10.3346/jkms.2004.19.5.682,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Genetic alterations in intrahepatic cholangiocarcinoma as revealed by degenerate oligonucleotide primed PCR-comparative genomic hybridization.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Genetic alterations in intrahepatic cholangiocarcinoma as revealed by degenerate oligonucleotide primed PCR-comparative genomic hybridization.
38917,68086,15287980,10.1186/gb-2004-5-8-r58,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: POSaM: a fast, flexible, open-source, inkjet oligonucleotide synthesizer and microarrayer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"POSaM: a fast, flexible, open-source, inkjet oligonucleotide synthesizer and microarrayer."
38918,68087,15155822,10.1093/nar/gnh067,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Oligonucleotide hybridization studied by a surface plasmon diffraction sensor (SPDS).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Oligonucleotide hybridization studied by a surface plasmon diffraction sensor (SPDS).
38919,68088,15131181,10.1128/JCM.42.5.2134-2143.2004,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Simultaneous analysis of multiple staphylococcal enterotoxin genes by an oligonucleotide microarray assay.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Simultaneous analysis of multiple staphylococcal enterotoxin genes by an oligonucleotide microarray assay.
38920,68089,15574827,10.1101/gr.2845604,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues.
38921,68090,14525931,10.1101/gr.1575003,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: High-throughput selection of effective RNAi probes for gene silencing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,High-throughput selection of effective RNAi probes for gene silencing.
38922,68091,14525932,10.1101/gr.1478703,offtarget,siRNA,PMC full text high-precision preselection,microarray;rnai,"full-text off-target candidate; title/source terms=microarray, rnai; source title: RNAi microarray analysis in cultured mammalian cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi microarray analysis in cultured mammalian cells.
38923,68092,12730368,10.1073/pnas.1037853100,offtarget,siRNA,PMC full text high-precision preselection,silencing;small interfering,"full-text off-target candidate; title/source terms=silencing, small interfering; source title: Genomewide view of gene silencing by small interfering RNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Genomewide view of gene silencing by small interfering RNAs.
38924,68093,12554663,10.1093/emboj/cdg74,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: Low temperature inhibits RNA silencing-mediated defence by the control of siRNA generation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Low temperature inhibits RNA silencing-mediated defence by the control of siRNA generation.
38925,68094,12600936,10.1101/gad.1064703,offtarget,siRNA,PMC full text high-precision preselection,mirna;sirna,"full-text off-target candidate; title/source terms=mirna, sirna; source title: siRNAs can function as miRNAs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNAs can function as miRNAs.
38926,68095,12560494,10.1093/nar/gkg184,offtarget,siRNA,PMC full text high-precision preselection,silencing;sirna,"full-text off-target candidate; title/source terms=silencing, sirna; source title: siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells.
38927,68096,12527779,10.1093/nar/gkg158,offtarget,siRNA,PMC full text high-precision preselection,silencing;rnai,"full-text off-target candidate; title/source terms=silencing, rnai; source title: Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells.
38928,68097,12518068,10.1073/pnas.262663799,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain: Evidence from high-density oligonucleotide arrays and in situ hybridization.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain: Evidence from high-density oligonucleotide arrays and in situ hybridization.
38929,68098,12655023,10.1093/nar/gng035,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Light-directed 5'-->3' synthesis of complex oligonucleotide microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Light-directed 5'-->3' synthesis of complex oligonucleotide microarrays.
38930,68099,12799432,10.1093/nar/gkg426,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: OligoArray 2.0: design of oligonucleotide probes for DNA microarrays using a thermodynamic approach.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,OligoArray 2.0: design of oligonucleotide probes for DNA microarrays using a thermodynamic approach.
38931,68100,12034852,10.1093/nar/30.11.e51,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Optimization of oligonucleotide-based DNA microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Optimization of oligonucleotide-based DNA microarrays.
38932,68101,11867738,10.1073/pnas.052678999,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Analysis of the ultraviolet B response in primary human keratinocytes using oligonucleotide microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Analysis of the ultraviolet B response in primary human keratinocytes using oligonucleotide microarrays.
38933,68102,12384608,10.1093/nar/gnf105,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: A computational framework for optimal masking in the synthesis of oligonucleotide microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A computational framework for optimal masking in the synthesis of oligonucleotide microarrays.
38934,68103,12136120,10.1093/nar/gnf072,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Detection of oligonucleotide hybridization at femtomolar level and sequence-specific gene analysis of the Arabidopsis thaliana leaf extract with an ultrasensitive surface plasmon resonance spectrometer.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Detection of oligonucleotide hybridization at femtomolar level and sequence-specific gene analysis of the Arabidopsis thaliana leaf extract with an ultrasensitive surface plasmon resonance spectrometer.
38935,68104,12387859,10.1016/s0014-5793(02)03309-4,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis.
38936,68105,12413464,10.1016/s0003-2697(02)00294-4,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays.
38937,68106,11948171,10.1128/JB.184.9.2546-2551.2002,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Analysis of the heat shock response of Neisseria meningitidis with cDNA- and oligonucleotide-based DNA microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Analysis of the heat shock response of Neisseria meningitidis with cDNA- and oligonucleotide-based DNA microarrays.
38938,68107,11266571,10.1093/nar/29.7.e36,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,microarray;oligonucleotide,"full-text off-target candidate; title/source terms=microarray, oligonucleotide; source title: Detection of mitochondrial single nucleotide polymorphisms using a primer elongation reaction on oligonucleotide microarrays.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Detection of mitochondrial single nucleotide polymorphisms using a primer elongation reaction on oligonucleotide microarrays.
38939,68108,11337360,10.1016/S0002-9440(10)64118-1,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Degenerate oligonucleotide primed-polymerase chain reaction-based array comparative genomic hybridization for extensive amplicon profiling of breast cancers : a new approach for the molecular analysis of paraffin-embedded cancer tissue.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Degenerate oligonucleotide primed-polymerase chain reaction-based array comparative genomic hybridization for extensive amplicon profiling of breast cancers : a new approach for the molecular analysis of paraffin-embedded cancer tissue.
38940,68109,10864048,10.1017/s1355838200000339,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Enhanced detection of tRNA isoacceptors by combinatorial oligonucleotide hybridization.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced detection of tRNA isoacceptors by combinatorial oligonucleotide hybridization.
38941,68110,10734200,10.1093/nar/28.8.1802,offtarget,ASO,PMC full text high-precision preselection,hybridization;antisense,"full-text off-target candidate; title/source terms=hybridization, antisense; source title: Identification of iron responsive genes by screening cDNA libraries from suppression subtractive hybridization with antisense probes from three iron conditions.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of iron responsive genes by screening cDNA libraries from suppression subtractive hybridization with antisense probes from three iron conditions.
38942,68111,10655385,10.1128/JCM.38.2.781-788.2000,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Rapid diagnosis of bacteremia by universal amplification of 23S ribosomal DNA followed by hybridization to an oligonucleotide array.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rapid diagnosis of bacteremia by universal amplification of 23S ribosomal DNA followed by hybridization to an oligonucleotide array.
38943,68112,10482513,10.1128/JB.181.18.5718-5724.1999,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Identification of sigma(B)-dependent genes in Bacillus subtilis using a promoter consensus-directed search and oligonucleotide hybridization.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Identification of sigma(B)-dependent genes in Bacillus subtilis using a promoter consensus-directed search and oligonucleotide hybridization.
38944,68113,9628910,10.1093/nar/26.13.3136,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Synthesis and hybridization analysis of a small library of peptide-oligonucleotide conjugates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Synthesis and hybridization analysis of a small library of peptide-oligonucleotide conjugates.
38945,68114,9685507,10.1093/nar/26.16.3865,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,hybridization;oligonucleotide,"full-text off-target candidate; title/source terms=hybridization, oligonucleotide; source title: Two color hybridization analysis using high density oligonucleotide arrays and energy transfer dyes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Two color hybridization analysis using high density oligonucleotide arrays and energy transfer dyes.
38946,68115,42112101,10.1016/j.omtn.2026.102933,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, aso, gapmer, oligonucleotide, oligonucleotides; source title: ClinASO: An open-source platform for rapid drug discovery of gapmer antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,ClinASO: An open-source platform for rapid drug discovery of gapmer antisense oligonucleotides.
38947,68116,41536811,10.1016/j.omtn.2025.102791,offtarget,ASO,PMC full text high-precision preselection,antisense;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, gapmer, oligonucleotide, oligonucleotides; source title: DUX4 reduction and muscle function improvement by subcutaneous delivery of gapmer antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,DUX4 reduction and muscle function improvement by subcutaneous delivery of gapmer antisense oligonucleotides.
38948,68117,40151235,10.1021/jacsau.5c00012,offtarget,siRNA,PMC full text high-precision preselection,sirna;oligonucleotide;oligonucleotides;galnac,"full-text off-target candidate; title/source terms=sirna, oligonucleotide, oligonucleotides, galnac; source title: General Platform for Efficient and Modular Assembly of GalNAc-siRNA Conjugates via Primary Amines and o-Nitrobenzyl Alcohol Cyclization Photoclick Chemistry Enabling Rapid Access to Therapeutic Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,General Platform for Efficient and Modular Assembly of GalNAc-siRNA Conjugates via Primary Amines and o-Nitrobenzyl Alcohol Cyclization Photoclick Chemistry Enabling Rapid Access to Therapeutic Oligonucleotides.
38949,68118,40425312,10.1261/rna.080288.124,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide, oligonucleotides; source title: OpenASO: RNA Rescue-designing splice-modulating antisense oligonucleotides through community science.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,OpenASO: RNA Rescue-designing splice-modulating antisense oligonucleotides through community science.
38950,68119,41220634,10.1039/d5ra05904f,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide, oligonucleotides; source title: Enhancing the intracellular delivery of antisense oligonucleotides (ASO) : a comparative study of aptamer, vitamin E, and cholesterol ASO conjugates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Enhancing the intracellular delivery of antisense oligonucleotides (ASO) : a comparative study of aptamer, vitamin E, and cholesterol ASO conjugates."
38951,68120,39011883,10.1093/nar/gkae624,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide, oligonucleotides; source title: mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs).",B,high_candidate,curator_rejected,reject,derived_annotations_only,mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs).
38952,68121,38706632,10.1016/j.omtn.2024.102186,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide, oligonucleotides; source title: ASOptimizer: Optimizing antisense oligonucleotides through deep learning for IDO1 gene regulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ASOptimizer: Optimizing antisense oligonucleotides through deep learning for IDO1 gene regulation.
38953,68122,38732027,10.3390/ijms25094809,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide, oligonucleotides; source title: Antisense Oligonucleotides (ASOs) in Motor Neuron Diseases: A Road to Cure in Light and Shade.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense Oligonucleotides (ASOs) in Motor Neuron Diseases: A Road to Cure in Light and Shade.
38954,68123,36454263,10.1089/nat.2022.0044,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides;galnac,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides, galnac; source title: Integrated Assessment of Phase 2 Data on GalNAc(3)-Conjugated 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Integrated Assessment of Phase 2 Data on GalNAc(3)-Conjugated 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides.
38955,68124,37111598,10.3390/pharmaceutics15041112,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide, oligonucleotides; source title: Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny."
38956,68125,35801870,10.1093/nar/gkac562,offtarget,ASO,PMC full text high-precision preselection,antisense;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, gapmer, oligonucleotide, oligonucleotides; source title: Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Identification of nucleobase chemical modifications that reduce the hepatotoxicity of gapmer antisense oligonucleotides.
38957,68126,36511872,10.1093/nar/gkac1108,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide, oligonucleotides; source title: G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects.
38958,68127,34417625,10.1093/nar/gkab718,offtarget,ASO,PMC full text high-precision preselection,antisense;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, gapmer, oligonucleotide, oligonucleotides; source title: Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
38959,68128,33734715,10.1021/acs.molpharmaceut.0c01238,offtarget,siRNA,PMC full text high-precision preselection,small interfering;antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=small interfering, antisense, oligonucleotide, oligonucleotides; source title: Advances in the Design of (Nano)Formulations for Delivery of Antisense Oligonucleotides and Small Interfering RNA: Focus on the Central Nervous System.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Advances in the Design of (Nano)Formulations for Delivery of Antisense Oligonucleotides and Small Interfering RNA: Focus on the Central Nervous System.
38960,68129,31980820,10.1093/nar/gkaa031,offtarget,ASO,PMC full text high-precision preselection,antisense;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, gapmer, oligonucleotide, oligonucleotides; source title: Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.
38961,68130,30570431,10.1089/nat.2018.0753,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides;galnac,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides, galnac; source title: Integrated Assessment of the Clinical Performance of GalNAc(3)-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Integrated Assessment of the Clinical Performance of GalNAc(3)-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.
38962,68131,31631092,10.1262/jrd.2019-070,offtarget,siRNA,PMC full text high-precision preselection,sirna;rnai;small interfering;shrna,"full-text off-target candidate; title/source terms=sirna, rnai, small interfering, shrna; source title: Improvement of developmental competence of cloned male pig embryos by short hairpin ribonucleic acid (shRNA) vector-based but not small interfering RNA (siRNA)-mediated RNA interference (RNAi) of Xist expression.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Improvement of developmental competence of cloned male pig embryos by short hairpin ribonucleic acid (shRNA) vector-based but not small interfering RNA (siRNA)-mediated RNA interference (RNAi) of Xist expression.
38963,68132,27461380,10.1038/srep30377,offtarget,ASO,PMC full text high-precision preselection,antisense;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, gapmer, oligonucleotide, oligonucleotides; source title: Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides.
38964,68133,26553810,10.1093/nar/gkv1210,offtarget,ASO,PMC full text high-precision preselection,antisense;gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, gapmer, oligonucleotide, oligonucleotides; source title: Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
38965,68134,26908652,10.1093/nar/gkw112,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide, oligonucleotides; source title: Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver.
38966,68135,41760661,10.1038/s41467-026-69980-2,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides.
38967,68136,41494985,10.1093/nar/gkaf1333,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Acute neuronal inhibition response caused by phosphorothioate antisense oligonucleotides following local delivery to the central nervous system.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Acute neuronal inhibition response caused by phosphorothioate antisense oligonucleotides following local delivery to the central nervous system.
38968,68137,41878536,10.3389/fonc.2026.1659341,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Targeting TLK2 with antisense oligonucleotides as a new strategy in acute myeloid leukemia.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting TLK2 with antisense oligonucleotides as a new strategy in acute myeloid leukemia.
38969,68138,42033225,10.1093/nar/gkag343,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Direct targeting of C9ORF72 repeat RNA with fluorinated antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Direct targeting of C9ORF72 repeat RNA with fluorinated antisense oligonucleotides.
38970,68139,41399312,10.1002/smll.202509094,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Delivery of Antisense Oligonucleotides Using the Nano-Cell Vesicle Technology System (nCVTs) for Targeted Cancer Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery of Antisense Oligonucleotides Using the Nano-Cell Vesicle Technology System (nCVTs) for Targeted Cancer Therapy.
38971,68140,41928909,10.1039/d5cb00316d,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity.
38972,68141,41856548,10.1002/jms.70049,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Characterisation of Antisense Oligonucleotides by Ion-Pair Reversed-Phase UHPLC-HRMS: Method development using Design of Experiments.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Characterisation of Antisense Oligonucleotides by Ion-Pair Reversed-Phase UHPLC-HRMS: Method development using Design of Experiments.
38973,68142,41810474,10.1016/j.ajps.2026.101128,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Freezing shock monocytes deliver antisense oligonucleotides via liposomes for the treatment of idiopathic pulmonary fibrosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Freezing shock monocytes deliver antisense oligonucleotides via liposomes for the treatment of idiopathic pulmonary fibrosis.
38974,68143,41722569,10.1016/j.ajhg.2026.01.016,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for myotonic dystrophy type 1.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for myotonic dystrophy type 1.
38975,68144,42182263,10.64898/2026.05.11.724403,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Naked antisense oligonucleotides remain endolysosomally sequestered despite induced membrane damage.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Naked antisense oligonucleotides remain endolysosomally sequestered despite induced membrane damage.
38976,68145,41992206,10.1186/s12917-026-05465-0,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Delivery and uptake of free and liposome-encapsulated cholesterol-conjugated antisense oligonucleotides in Atlantic salmon sperm: insights from high-resolution imaging.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery and uptake of free and liposome-encapsulated cholesterol-conjugated antisense oligonucleotides in Atlantic salmon sperm: insights from high-resolution imaging.
38977,68146,41050468,10.1016/j.csbj.2025.09.022,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide; source title: ASOG: AntiSense Oligonucleotide Generator.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ASOG: AntiSense Oligonucleotide Generator.
38978,68147,40534528,10.4062/biomolther.2025.022,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: RNA Therapeutics: Focus on Antisense Oligonucleotides in the Nervous System.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA Therapeutics: Focus on Antisense Oligonucleotides in the Nervous System.
38979,68148,41467114,10.1016/j.omtn.2025.102692,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Unraveling and controlling late-onset neurotoxicity of antisense oligonucleotides through strategic chemical modifications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Unraveling and controlling late-onset neurotoxicity of antisense oligonucleotides through strategic chemical modifications.
38980,68149,41021771,10.1111/cts.70344,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;galnac,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, galnac; source title: Pharmacokinetics and Safety of Pelacarsen, a GalNAc(3)-Conjugated Antisense Oligonucleotide Targeting Apo(a), in Participants With Mild Hepatic Impairment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Pharmacokinetics and Safety of Pelacarsen, a GalNAc(3)-Conjugated Antisense Oligonucleotide Targeting Apo(a), in Participants With Mild Hepatic Impairment."
38981,68150,39850319,10.1016/j.omtn.2024.102387,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney.
38982,68151,41465141,10.3390/genes16121468,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Artificial Intelligence-Driven Design of Antisense Oligonucleotides for Precision Medicine in Neuromuscular Disorders.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Artificial Intelligence-Driven Design of Antisense Oligonucleotides for Precision Medicine in Neuromuscular Disorders.
38983,68152,40119340,10.1186/s12944-024-02389-2,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Safety and efficacy of antisense oligonucleotides on triglyceride, apolipoprotein C-III, and other lipid parameters levels in hypertriglyceridemia; a network meta-analysis of randomized controlled trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Safety and efficacy of antisense oligonucleotides on triglyceride, apolipoprotein C-III, and other lipid parameters levels in hypertriglyceridemia; a network meta-analysis of randomized controlled trials."
38984,68153,40034209,10.1016/j.omtn.2025.102476,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: SNA-modified antisense oligonucleotides: A new pathway for renal targeting?",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,SNA-modified antisense oligonucleotides: A new pathway for renal targeting?
38985,68154,41451936,10.1002/cpz1.70292,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Synthesis of 4'-C-α-Aminoethoxy-2'-O-Methyl-5-Methyl- and 5-Propynyl-Uridine Phosphoramidites for Structurally Optimized Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synthesis of 4'-C-α-Aminoethoxy-2'-O-Methyl-5-Methyl- and 5-Propynyl-Uridine Phosphoramidites for Structurally Optimized Antisense Oligonucleotides.
38986,68155,41303530,10.3390/ijms262211047,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Structural Characterization of DDX23 5' UTR Regulatory Elements and Their Targeting by LNA-Modified Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Structural Characterization of DDX23 5' UTR Regulatory Elements and Their Targeting by LNA-Modified Antisense Oligonucleotides.
38987,68156,41206040,10.1093/nar/gkaf1116,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation.
38988,68157,40926414,10.1016/j.ymthe.2025.08.045,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides.
38989,68158,40727088,10.1016/j.omtn.2025.102615,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Tailored antisense oligonucleotides for ultrarare CNS diseases: An experience-based best practice framework for individual patient evaluation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tailored antisense oligonucleotides for ultrarare CNS diseases: An experience-based best practice framework for individual patient evaluation.
38990,68159,40556776,10.1021/acsbiomedchemau.5c00004,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: RNA G‑Quadruplex Reprogramming with Guanine-Rich Antisense Oligonucleotides Inhibits Monoamine Oxidase B's Translation.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNA G‑Quadruplex Reprogramming with Guanine-Rich Antisense Oligonucleotides Inhibits Monoamine Oxidase B's Translation.
38991,68160,40339155,10.1002/alz.70022,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome.
38992,68161,40303997,10.3389/fonc.2025.1563985,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Identifying antisense oligonucleotides for targeted inhibition of insulin receptor isoform A.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Identifying antisense oligonucleotides for targeted inhibition of insulin receptor isoform A.
38993,68162,40268518,10.1002/ctm2.70314,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Skeletal muscle effects of antisense oligonucleotides targeting glycogen synthase 1 in a mouse model of Pompe disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Skeletal muscle effects of antisense oligonucleotides targeting glycogen synthase 1 in a mouse model of Pompe disease.
38994,68163,40243849,10.3390/ijms26073098,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model.
38995,68164,40076889,10.3390/ijms26052270,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Expansion of Splice-Switching Therapy with Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Expansion of Splice-Switching Therapy with Antisense Oligonucleotides.
38996,68165,39974615,10.3389/fchem.2025.1548269,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management.
38997,68166,39967902,10.2147/DDDT.S507402,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Lipid Nanovesicles in Cancer Treatment: Improving Targeting and Stability of Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Lipid Nanovesicles in Cancer Treatment: Improving Targeting and Stability of Antisense Oligonucleotides.
38998,68167,39793573,10.1016/j.xcrm.2024.101901,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Phase 1/2 trial of brogidirsen: Dual-targeting antisense oligonucleotides for exon 44 skipping in Duchenne muscular dystrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phase 1/2 trial of brogidirsen: Dual-targeting antisense oligonucleotides for exon 44 skipping in Duchenne muscular dystrophy.
38999,68168,39653607,10.1080/17460441.2024.2440095,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Evolution of antisense oligonucleotides: navigating nucleic acid chemistry and delivery challenges.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evolution of antisense oligonucleotides: navigating nucleic acid chemistry and delivery challenges.
39000,68169,41169576,10.1021/jacsau.5c01005,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides."
39001,68170,40083647,10.1016/j.omtn.2025.102497,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Erratum: In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Erratum: In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney.
39002,68171,41346243,10.1080/17435889.2025.2596219,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Inhibition of calreticulin by protein nanoparticles carrying antisense oligonucleotides reduce gene expression and infection of Trypanosoma cruzi trypomastigotes on mammalian cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of calreticulin by protein nanoparticles carrying antisense oligonucleotides reduce gene expression and infection of Trypanosoma cruzi trypomastigotes on mammalian cells.
39003,68172,40308063,10.1016/j.ymthe.2025.04.038,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Clinical applications of exon-skipping antisense oligonucleotides in neuromuscular diseases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clinical applications of exon-skipping antisense oligonucleotides in neuromuscular diseases.
39004,68173,39944202,10.3389/fendo.2025.1525373,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference.
39005,68174,40977082,10.1002/anie.202511386,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA-Charge Neutral Linkages for Enhanced Splice-Switching Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA-Charge Neutral Linkages for Enhanced Splice-Switching Antisense Oligonucleotides."
39006,68175,41355735,10.1002/ctm2.70530,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense oligonucleotides targeting valosin-containing protein ameliorate muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense oligonucleotides targeting valosin-containing protein ameliorate muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy.
39007,68176,40758869,10.1021/jacs.5c09544,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Harnessing BET-Bromodomain Assisted Nuclear Import for Targeted Subcellular Localization and Enhanced Efficacy of Antisense Oligonucleotides.
39008,68177,40747042,10.1021/jacsau.5c00584,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Programmable Single-Stranded Circular Antisense Oligonucleotides for Multitarget Gene Therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Programmable Single-Stranded Circular Antisense Oligonucleotides for Multitarget Gene Therapy.
39009,68178,40698145,10.1016/j.apsb.2025.05.004,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense oligonucleotides targeting IRF4 alleviate psoriasis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense oligonucleotides targeting IRF4 alleviate psoriasis.
39010,68179,40604820,10.1186/s12951-025-03529-1,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Ultrasmall nanoparticles for co-delivery of antisense oligonucleotides targeting miR-21 and miR-210 to treat glioblastoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Ultrasmall nanoparticles for co-delivery of antisense oligonucleotides targeting miR-21 and miR-210 to treat glioblastoma.
39011,68180,40559999,10.1089/nat.2024.0067,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Exosome-Mediated Mitochondrial Delivery of Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Exosome-Mediated Mitochondrial Delivery of Antisense Oligonucleotides.
39012,68181,40547092,10.1039/d5sc03751d,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking.
39013,68182,40529507,10.3389/fphar.2025.1564682,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: SNORA13 antisense oligonucleotides enhances the therapeutical effects of 5-fluorouracil in colon adenocarcinoma.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,SNORA13 antisense oligonucleotides enhances the therapeutical effects of 5-fluorouracil in colon adenocarcinoma.
39014,68183,40473123,10.1016/j.nbd.2025.106986,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.
39015,68184,39845577,10.1177/17562864251313915,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Tofersen and other antisense oligonucleotides in ALS.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tofersen and other antisense oligonucleotides in ALS.
39016,68185,39282364,10.1101/2024.09.06.611206,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation.
39017,68186,40181256,10.1186/s12865-025-00685-9,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Modulating immune responses in alopecia: therapeutic insights and potential targets of antisense oligonucleotides.
39018,68187,39897576,10.1016/j.omtn.2024.102432,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Personalized allele-specific antisense oligonucleotides for GNAO1-neurodevelopmental disorder.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Personalized allele-specific antisense oligonucleotides for GNAO1-neurodevelopmental disorder.
39019,68188,38660533,10.1039/d4ra01925c,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Inhibition of survivin by 2'-O-methyl phosphorothioate-modified steric-blocking antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhibition of survivin by 2'-O-methyl phosphorothioate-modified steric-blocking antisense oligonucleotides.
39020,68189,39911828,10.3389/fphar.2024.1481937,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Characterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method.
39021,68190,39062597,10.3390/biom14070883,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Rational Design of Chimeric Antisense Oligonucleotides on a Mixed PO-PS Backbone for Splice-Switching Applications.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Rational Design of Chimeric Antisense Oligonucleotides on a Mixed PO-PS Backbone for Splice-Switching Applications.
39022,68191,39027419,10.1016/j.omtn.2024.102246,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Preclinical evaluation of stereopure antisense oligonucleotides for allele-selective lowering of mutant HTT.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Preclinical evaluation of stereopure antisense oligonucleotides for allele-selective lowering of mutant HTT.
39023,68192,38773176,10.1038/s41598-024-61666-3,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation.
39024,68193,38501046,10.3389/fchem.2024.1342178,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Structure-activity relationship study of mesyl and busyl phosphoramidate antisense oligonucleotides for unaided and PSMA-mediated uptake into prostate cancer cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Structure-activity relationship study of mesyl and busyl phosphoramidate antisense oligonucleotides for unaided and PSMA-mediated uptake into prostate cancer cells.
39025,68194,38978695,10.1016/j.omtn.2024.102161,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2',4'-BNA/LNA with 9-(aminoethoxy)phenoxazine."
39026,68195,39119918,10.1093/nar/gkae686,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Efficacy, biodistribution and safety comparison of chemically modified antisense oligonucleotides in the retina.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Efficacy, biodistribution and safety comparison of chemically modified antisense oligonucleotides in the retina."
39027,68196,39494149,10.1016/j.omtn.2024.102351,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide; source title: Mechanistic insights into ASO-RNA complexation: Advancing antisense oligonucleotide design strategies.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mechanistic insights into ASO-RNA complexation: Advancing antisense oligonucleotide design strategies.
39028,68197,39460376,10.1016/j.ymthe.2024.10.024,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system.
39029,68198,39335447,10.3390/biomedicines12091933,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Calcium-Enhanced Medium-Based Delivery of Splice Modulating Antisense Oligonucleotides in 2D and 3D hiPSC-Derived Neuronal Models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Calcium-Enhanced Medium-Based Delivery of Splice Modulating Antisense Oligonucleotides in 2D and 3D hiPSC-Derived Neuronal Models.
39030,68199,39126066,10.3390/ijms25158495,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Allele-Selective Thiomorpholino Antisense Oligonucleotides as a Therapeutic Approach for Fused-in-Sarcoma Amyotrophic Lateral Sclerosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Allele-Selective Thiomorpholino Antisense Oligonucleotides as a Therapeutic Approach for Fused-in-Sarcoma Amyotrophic Lateral Sclerosis.
39031,68200,39304746,10.1038/s41416-024-02859-5,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer.
39032,68201,38893532,10.3390/molecules29112658,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Potential of Cell-Penetrating Peptide-Conjugated Antisense Oligonucleotides for the Treatment of SMA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Potential of Cell-Penetrating Peptide-Conjugated Antisense Oligonucleotides for the Treatment of SMA.
39033,68202,38654375,10.1186/s13024-024-00725-9,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.
39034,68203,38464319,10.1101/2024.02.22.580414,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Skeletal muscle effects of antisense oligonucleotides targeting glycogen synthase 1 in a mouse model of Pompe disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Skeletal muscle effects of antisense oligonucleotides targeting glycogen synthase 1 in a mouse model of Pompe disease.
39035,68204,38419941,10.1016/j.omtn.2024.102133,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Tissue pharmacokinetics of antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tissue pharmacokinetics of antisense oligonucleotides.
39036,68205,39594617,10.3390/cells13221869,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Clinical Applications of Antisense Oligonucleotides in Cancer: A Focus on Glioblastoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Clinical Applications of Antisense Oligonucleotides in Cancer: A Focus on Glioblastoma.
39037,68206,39526481,10.1111/cns.70050,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense oligonucleotides as a precision therapy for developmental and epileptic encephalopathies.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense oligonucleotides as a precision therapy for developmental and epileptic encephalopathies.
39038,68207,39379106,10.1261/rna.080220.124,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Site-blocking antisense oligonucleotides as a mechanism to fine-tune MeCP2 expression.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Site-blocking antisense oligonucleotides as a mechanism to fine-tune MeCP2 expression.
39039,68208,39309360,10.1039/d4md00394b,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: The bench to bedside journey of tricyclo-DNA antisense oligonucleotides for the treatment of Duchenne muscular dystrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The bench to bedside journey of tricyclo-DNA antisense oligonucleotides for the treatment of Duchenne muscular dystrophy.
39040,68209,39303667,10.1016/j.ebiom.2024.105356,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer.
39041,68210,39272802,10.3390/cancers16172940,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Therapeutic Antisense Oligonucleotides in Oncology: From Bench to Bedside.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic Antisense Oligonucleotides in Oncology: From Bench to Bedside.
39042,68211,38792022,10.3390/cancers16101944,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense Oligonucleotides for Rapid Translation of Gene Therapy in Glioblastoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense Oligonucleotides for Rapid Translation of Gene Therapy in Glioblastoma.
39043,68212,38716830,10.1089/nat.2023.0070,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Screening Splice-Switching Antisense Oligonucleotides in Pancreas-Cancer Organoids.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Screening Splice-Switching Antisense Oligonucleotides in Pancreas-Cancer Organoids.
39044,68213,38607040,10.3390/cells13070601,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Preclinical Development of Antisense Oligonucleotides to Rescue Aberrant Splicing Caused by an Ultrarare ABCA4 Variant in a Child with Early-Onset Stargardt Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Preclinical Development of Antisense Oligonucleotides to Rescue Aberrant Splicing Caused by an Ultrarare ABCA4 Variant in a Child with Early-Onset Stargardt Disease.
39045,68214,38511173,10.1016/j.omtn.2024.102154,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: STAT6-targeting antisense oligonucleotides against solitary fibrous tumor.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,STAT6-targeting antisense oligonucleotides against solitary fibrous tumor.
39046,68215,38499569,10.1038/s41598-024-56704-z,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration.
39047,68216,38357922,10.1172/JCI169562,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy.
39048,68217,39376536,10.3389/fnins.2024.1414658,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense oligonucleotides and their applications in rare neurological diseases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense oligonucleotides and their applications in rare neurological diseases.
39049,68218,37036788,10.1089/nat.2022.0063,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Next Generation Exon 51 Skipping Antisense Oligonucleotides for Duchenne Muscular Dystrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Next Generation Exon 51 Skipping Antisense Oligonucleotides for Duchenne Muscular Dystrophy.
39050,68219,36579950,10.1089/nat.2022.0061,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides.
39051,68220,38010230,10.1089/nat.2023.0038,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy.
39052,68221,38192302,10.3389/fnmol.2023.1320182,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Evaluating the efficacy of purchased antisense oligonucleotides to reduce mouse and human tau in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluating the efficacy of purchased antisense oligonucleotides to reduce mouse and human tau in vivo.
39053,68222,37588686,10.1016/j.omtn.2023.07.022,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Cathepsin B-activatable cyclic antisense oligonucleotides for cell-specific target gene knockdown in vitro and in vivo.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Cathepsin B-activatable cyclic antisense oligonucleotides for cell-specific target gene knockdown in vitro and in vivo.
39054,68223,37034721,10.1101/2023.03.31.535160,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Rescue of blood coagulation Factor VIII exon-16 mis-splicing by antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rescue of blood coagulation Factor VIII exon-16 mis-splicing by antisense oligonucleotides.
39055,68224,36791388,10.1002/cbic.202300009,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Investigation of Sequence-Penetration Relationships of Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Investigation of Sequence-Penetration Relationships of Antisense Oligonucleotides.
39056,68225,36700864,10.1158/2326-6066.CIR-22-0547,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Inhibition of STAT6 with Antisense Oligonucleotides Enhances the Systemic Antitumor Effects of Radiotherapy and Anti-PD-1 in Metastatic Non-Small Cell Lung Cancer.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Inhibition of STAT6 with Antisense Oligonucleotides Enhances the Systemic Antitumor Effects of Radiotherapy and Anti-PD-1 in Metastatic Non-Small Cell Lung Cancer.
39057,68226,36700050,10.1016/j.omtn.2022.12.010,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route.
39058,68227,38019311,10.1007/s00401-023-02652-3,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: G(2)C(4) targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,G(2)C(4) targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons.
39059,68228,37704069,10.1016/j.bone.2023.116898,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense oligonucleotides targeting a NOTCH3 mutation in male mice ameliorate the cortical osteopenia of lateral meningocele syndrome.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense oligonucleotides targeting a NOTCH3 mutation in male mice ameliorate the cortical osteopenia of lateral meningocele syndrome.
39060,68229,37376093,10.3390/pharmaceutics15061645,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Synthesis, Biophysical Properties, and Antitumor Activity of Antisense Oligonucleotides Conjugated with Anisamide.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Synthesis, Biophysical Properties, and Antitumor Activity of Antisense Oligonucleotides Conjugated with Anisamide."
39061,68230,37066201,10.1101/2023.03.31.535161,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Preclinical Screening of Splice-Switching Antisense Oligonucleotides in PDAC Organoids.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical Screening of Splice-Switching Antisense Oligonucleotides in PDAC Organoids.
39062,68231,36817728,10.1016/j.omtn.2023.01.006,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.
39063,68232,36577600,10.1016/j.atherosclerosis.2022.12.003,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Targeting and delivery of microRNA-targeting antisense oligonucleotides in cardiovascular diseases.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeting and delivery of microRNA-targeting antisense oligonucleotides in cardiovascular diseases.
39064,68233,36516128,10.1089/nat.2022.0060,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Consensus Guidelines for the Design and In Vitro Preclinical Efficacy Testing N-of-1 Exon Skipping Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Consensus Guidelines for the Design and In Vitro Preclinical Efficacy Testing N-of-1 Exon Skipping Antisense Oligonucleotides.
39065,68234,35861704,10.1089/nat.2022.0005,offtarget,ASO,PMC full text high-precision preselection,antisense;aso;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, aso, oligonucleotide; source title: The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs.
39066,68235,35057094,10.3390/pharmaceutics14010200,offtarget,ASO,PMC full text high-precision preselection,antisense;gapmer;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, gapmer, oligonucleotide; source title: Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders.
39067,68236,35860385,10.1016/j.omtn.2022.06.015,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models."
39068,68237,35080855,10.1021/acs.bioconjchem.1c00505,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Gene Regulation Using Nanodiscs Modified with HIF-1-α Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Gene Regulation Using Nanodiscs Modified with HIF-1-α Antisense Oligonucleotides.
39069,68238,34928745,10.1089/nat.2021.0040,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Quantification of Antisense Oligonucleotides by Splint Ligation and Quantitative Polymerase Chain Reaction.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Quantification of Antisense Oligonucleotides by Splint Ligation and Quantitative Polymerase Chain Reaction.
39070,68239,35166597,10.1089/nat.2021.0071,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features.
39071,68240,36036621,10.3791/63324,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development.
39072,68241,35056851,10.3390/molecules27020536,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Small Drugs, Huge Impact: The Extraordinary Impact of Antisense Oligonucleotides in Research and Drug Development.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Small Drugs, Huge Impact: The Extraordinary Impact of Antisense Oligonucleotides in Research and Drug Development."
39073,68242,35036069,10.1016/j.omtn.2021.12.029,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Glioma-targeted delivery of exosome-encapsulated antisense oligonucleotides using neural stem cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Glioma-targeted delivery of exosome-encapsulated antisense oligonucleotides using neural stem cells.
39074,68243,34797690,10.1089/nat.2021.0059,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Differential Uptake of Antisense Oligonucleotides in Mouse Hepatocytes and Macrophages Revealed by Simultaneous Two-Photon Excited Fluorescence and Coherent Raman Imaging.
39075,68244,33567808,10.3324/haematol.2020.260059,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates."
39076,68245,35858356,10.1073/pnas.2113180119,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides.
39077,68246,36012138,10.3390/ijms23168875,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Transcript-Targeted Therapy Based on RNA Interference and Antisense Oligonucleotides: Current Applications and Novel Molecular Targets.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transcript-Targeted Therapy Based on RNA Interference and Antisense Oligonucleotides: Current Applications and Novel Molecular Targets.
39078,68247,35423918,10.1039/d1ra00878a,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Evaluation of DNA segments in 2'-modified RNA sequences in designing efficient splice switching antisense oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluation of DNA segments in 2'-modified RNA sequences in designing efficient splice switching antisense oligonucleotides.
39079,68248,34832896,10.3390/ph14111113,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Intramuscular Evaluation of Chimeric Locked Nucleic Acid/2'OMethyl-Modified Antisense Oligonucleotides for Targeted Exon 23 Skipping in Mdx Mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Intramuscular Evaluation of Chimeric Locked Nucleic Acid/2'OMethyl-Modified Antisense Oligonucleotides for Targeted Exon 23 Skipping in Mdx Mice.
39080,68249,34760338,10.1016/j.omtn.2021.10.008,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides.
39081,68250,34141070,10.1021/acsmedchemlett.1c00072,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides."
39082,68251,34085768,10.1002/psp4.12663,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: PK/PD modeling of FXI antisense oligonucleotides to bridge the dose-FXI activity relation from healthy volunteers to end-stage renal disease patients.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,PK/PD modeling of FXI antisense oligonucleotides to bridge the dose-FXI activity relation from healthy volunteers to end-stage renal disease patients.
39083,68252,34242101,10.1089/nat.2020.0917,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Improvements in the Tolerability Profile of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"Improvements in the Tolerability Profile of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods."
39084,68253,34059711,10.1038/s41598-021-90629-1,offtarget,ASO,PMC full text high-precision preselection,antisense;gapmer;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, gapmer, oligonucleotide; source title: Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics.
39085,68254,33540294,10.1016/j.thromres.2021.01.006,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense oligonucleotides and nucleic acids generate hypersensitive platelets.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense oligonucleotides and nucleic acids generate hypersensitive platelets.
39086,68255,34521352,10.1186/s12863-021-00992-1,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: The choice of negative control antisense oligonucleotides dramatically impacts downstream analysis depending on the cellular background.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,The choice of negative control antisense oligonucleotides dramatically impacts downstream analysis depending on the cellular background.
39087,68256,33676028,10.1016/j.molmet.2021.101204,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1.
39088,68257,32914209,10.1007/s00018-020-03632-6,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma.
39089,68258,33203730,10.1158/1535-7163.MCT-20-0599,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Targeting STAT3 with Proteolysis Targeting Chimeras and Next-Generation Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Targeting STAT3 with Proteolysis Targeting Chimeras and Next-Generation Antisense Oligonucleotides.
39090,68259,32592692,10.1016/j.ymthe.2020.06.015,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides;galnac,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides, galnac; source title: Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug.
39091,68260,32178467,10.3390/ijms21061952,offtarget,ASO,PMC full text high-precision preselection,antisense;gapmer;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, gapmer, oligonucleotide; source title: Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.
39092,68261,32160706,10.1016/j.omtn.2020.01.018,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo.
39093,68262,33288723,10.1073/pnas.2016158117,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency.
39094,68263,32269522,10.3389/fphar.2020.00220,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Pharmacokinetic Studies of Antisense Oligonucleotides Using MALDI-TOF Mass Spectrometry.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Pharmacokinetic Studies of Antisense Oligonucleotides Using MALDI-TOF Mass Spectrometry.
39095,68264,32260534,10.3390/biom10040553,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Chitosan Nanocomplexes for the Delivery of ENaC Antisense Oligonucleotides to Airway Epithelial Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Chitosan Nanocomplexes for the Delivery of ENaC Antisense Oligonucleotides to Airway Epithelial Cells.
39096,68265,32202944,10.1089/nat.2019.0838,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Delivery of Antisense Oligonucleotides to the Cornea.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Delivery of Antisense Oligonucleotides to the Cornea.
39097,68266,32170309,10.1093/nar/gkaa125,offtarget,siRNA,PMC full text high-precision preselection,sirna;rnai;galnac,"full-text off-target candidate; title/source terms=sirna, rnai, galnac; source title: Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.
39098,68267,32906697,10.3390/molecules25184083,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense Oligonucleotides Used to Identify Telomeric G-Quadruplexes in Metaphase Chromosomes and Fixed Cells by Fluorescence Lifetime Imaging Microscopy of o-BMVC Foci.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense Oligonucleotides Used to Identify Telomeric G-Quadruplexes in Metaphase Chromosomes and Fixed Cells by Fluorescence Lifetime Imaging Microscopy of o-BMVC Foci.
39099,68268,32544249,10.1093/nar/gkaa523,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Rational design of antisense oligonucleotides modulating the activity of TLR7/8 agonists.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rational design of antisense oligonucleotides modulating the activity of TLR7/8 agonists.
39100,68269,30583097,10.1016/j.omtn.2018.11.005,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;galnac,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, galnac; source title: GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.
39101,68270,30622178,10.1073/pnas.1813376116,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties.
39102,68271,30576769,10.1016/j.jcmgh.2018.12.004,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.
39103,68272,31070517,10.1089/nat.2019.0779,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations.
39104,68273,30837588,10.1038/s41598-019-40187-4,offtarget,siRNA,PMC full text high-precision preselection,sirna;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=sirna, oligonucleotide, oligonucleotides; source title: Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics.
39105,68274,29390093,10.1093/nar/gky060,offtarget,ASO,PMC full text high-precision preselection,gapmer;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=gapmer, oligonucleotide, oligonucleotides; source title: Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.
39106,68275,29425080,10.1089/nat.2017.0709,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver.
39107,68276,30020852,10.1089/nat.2018.0738,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Application of 2'-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Application of 2'-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides.
39108,68277,29858054,10.1016/j.omtn.2018.02.004,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice.
39109,68278,29806836,10.3791/57530,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Evaluation of Exon Inclusion Induced by Splice Switching Antisense Oligonucleotides in SMA Patient Fibroblasts.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of Exon Inclusion Induced by Splice Switching Antisense Oligonucleotides in SMA Patient Fibroblasts.
39110,68279,29437530,10.1089/nat.2017.0694,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation.
39111,68280,29792572,10.1089/nat.2018.0736,offtarget,siRNA,PMC full text high-precision preselection,sirna;rnai;galnac,"full-text off-target candidate; title/source terms=sirna, rnai, galnac; source title: GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics.
39112,68281,29246294,10.1016/j.omtn.2017.09.002,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Rational Design of Short Locked Nucleic Acid-Modified 2'-O-Methyl Antisense Oligonucleotides for Efficient Exon-Skipping In Vitro.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rational Design of Short Locked Nucleic Acid-Modified 2'-O-Methyl Antisense Oligonucleotides for Efficient Exon-Skipping In Vitro.
39113,68282,28145801,10.1089/nat.2016.0650,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: The Effects of 2'-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The Effects of 2'-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials.
39114,68283,30970855,10.3390/polym9050177,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice.
39115,68284,29246296,10.1016/j.omtn.2017.09.004,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes.
39116,68285,28799823,10.1089/nat.2017.0676,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Lack of QT Prolongation for 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Lack of QT Prolongation for 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects.
39117,68286,28375679,10.1089/nat.2016.0654,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Dual-Phase Iontophoresis for the Delivery of Antisense Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Dual-Phase Iontophoresis for the Delivery of Antisense Oligonucleotides.
39118,68287,28375678,10.1089/nat.2016.0641,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Intracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Intracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro.
39119,68288,28080221,10.1089/nat.2016.0656,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Molecular Mechanisms of Antisense Oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Molecular Mechanisms of Antisense Oligonucleotides.
39120,68289,29209494,10.1186/s40035-017-0101-9,offtarget,siRNA,PMC full text high-precision preselection,sirna;rnai;shrna,"full-text off-target candidate; title/source terms=sirna, rnai, shrna; source title: RNAi mechanisms in Huntington's disease therapy: siRNA versus shRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,RNAi mechanisms in Huntington's disease therapy: siRNA versus shRNA.
39121,68290,29242583,10.1038/s41598-017-17816-x,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Hybrid splicing minigene and antisense oligonucleotides as efficient tools to determine functional protein/RNA interactions.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Hybrid splicing minigene and antisense oligonucleotides as efficient tools to determine functional protein/RNA interactions.
39122,68291,27357629,10.1038/mt.2016.136,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Integrated Safety Assessment of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Integrated Safety Assessment of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers.
39123,68292,27285612,10.3791/53776,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy.
39124,68293,27854216,10.3233/JND-160146,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides.
39125,68294,26647160,10.18632/aging.100854,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).
39126,68295,26623937,10.1038/mtna.2015.39,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Evaluation of 2'-Deoxy-2'-fluoro Antisense Oligonucleotides for Exon Skipping in Duchenne Muscular Dystrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluation of 2'-Deoxy-2'-fluoro Antisense Oligonucleotides for Exon Skipping in Duchenne Muscular Dystrophy.
39127,68296,26366082,10.2147/IJN.S89910,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Cationic polyelectrolyte-mediated delivery of antisense morpholino oligonucleotides for exon-skipping in vitro and in mdx mice.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Cationic polyelectrolyte-mediated delivery of antisense morpholino oligonucleotides for exon-skipping in vitro and in mdx mice.
39128,68297,26042553,10.1021/acs.nanolett.5b00490,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.
39129,68298,24550163,10.1093/nar/gku142,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides.
39130,68299,25453815,10.1016/j.bmcl.2014.10.045,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Oligonucleotides conjugated with short chemically defined polyethylene glycol chains are efficient antisense agents.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Oligonucleotides conjugated with short chemically defined polyethylene glycol chains are efficient antisense agents.
39131,68300,24758560,10.1089/nat.2013.0470,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice.
39132,68301,24616511,10.1073/pnas.1402353111,offtarget,siRNA,PMC full text high-precision preselection,rnai;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=rnai, oligonucleotide, oligonucleotides; source title: Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens.
39133,68302,23344236,10.1038/mtna.2012.38,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Long-term Exon Skipping Studies With 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in Dystrophic Mouse Models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Long-term Exon Skipping Studies With 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in Dystrophic Mouse Models.
39134,68303,22108858,10.1038/mt.2011.260,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.
39135,68304,20615897,10.1093/nar/gkq457,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.
39136,68305,15576677,10.1093/nar/gnh168,offtarget,siRNA,PMC full text high-precision preselection,sirna;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=sirna, oligonucleotide, oligonucleotides; source title: Quantitative detection of siRNA and single-stranded oligonucleotides: relationship between uptake and biological activity of siRNA.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Quantitative detection of siRNA and single-stranded oligonucleotides: relationship between uptake and biological activity of siRNA.
39137,68306,15316104,10.1093/nar/gkh775,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides.
39138,68307,12853649,10.1093/nar/gng072,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: mRNA accessible site tagging (MAST): a novel high throughput method for selecting effective antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,mRNA accessible site tagging (MAST): a novel high throughput method for selecting effective antisense oligonucleotides.
39139,68308,12520089,,offtarget,siRNA,PMC full text high-precision preselection,small interfering;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=small interfering, oligonucleotide, oligonucleotides; source title: Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis.
39140,68309,12466540,10.1093/nar/gkf651,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design.
39141,68310,11353073,10.1093/nar/29.10.2041,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo.
39142,68311,10097067,10.1073/pnas.96.7.3513,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=antisense, oligonucleotide, oligonucleotides; source title: A cytosine analog that confers enhanced potency to antisense oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A cytosine analog that confers enhanced potency to antisense oligonucleotides.
39143,68312,42169802,10.1093/narmme/ugag025,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Correction to 'Integrating transcriptomics and proteomics to assess antisense oligonucleotide safety and efficacy: a time-resolved approach'.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Correction to 'Integrating transcriptomics and proteomics to assess antisense oligonucleotide safety and efficacy: a time-resolved approach'.
39144,68313,41918821,10.1093/narmme/ugag016,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Integrating transcriptomics and proteomics to assess antisense oligonucleotide safety and efficacy: a time-resolved approach.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Integrating transcriptomics and proteomics to assess antisense oligonucleotide safety and efficacy: a time-resolved approach.
39145,68314,41978261,10.1093/nar/gkag311,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Phosphorothioate antisense oligonucleotide induced innate immune activation is attenuated by tryptophan oxidation products.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Phosphorothioate antisense oligonucleotide induced innate immune activation is attenuated by tryptophan oxidation products.
39146,68315,42112102,10.1016/j.omtn.2026.102936,offtarget,siRNA,PMC full text high-precision preselection,sirna;galnac,"full-text off-target candidate; title/source terms=sirna, galnac; source title: A computational model-powered platform to inform the development of GalNAc-conjugated siRNA therapeutics.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A computational model-powered platform to inform the development of GalNAc-conjugated siRNA therapeutics.
39147,68316,42095135,10.1016/j.omtn.2026.102930,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Development of an exon 27-skipping antisense oligonucleotide as a targeted therapy for refractory skin ulcers in Werner syndrome.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Development of an exon 27-skipping antisense oligonucleotide as a targeted therapy for refractory skin ulcers in Werner syndrome.
39148,68317,41981306,10.1038/s41591-026-04314-9,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy.
39149,68318,41754970,10.3390/pharmaceutics18020228,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Unconventional Lysine-Type Lipid Assemblies Enable Efficient Antisense Oligonucleotide Delivery with Distinct Structural Features.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Unconventional Lysine-Type Lipid Assemblies Enable Efficient Antisense Oligonucleotide Delivery with Distinct Structural Features.
39150,68319,41624332,10.1016/j.omtn.2025.102815,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model.
39151,68320,41484831,10.1007/s40259-025-00761-x,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense Oligonucleotide Therapeutics Targeting Age-Related Diseases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense Oligonucleotide Therapeutics Targeting Age-Related Diseases.
39152,68321,41388232,10.1007/s40262-025-01606-0,offtarget,siRNA,PMC full text high-precision preselection,sirna;galnac,"full-text off-target candidate; title/source terms=sirna, galnac; source title: Platform Assessment of Concentration-QTc Relationship Across GalNAc-siRNA Molecules.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Platform Assessment of Concentration-QTc Relationship Across GalNAc-siRNA Molecules.
39153,68322,42042810,10.3390/vaccines14040334,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: CTLA-4 Antisense Oligonucleotide Contributes to Enhanced Immunogenicity of an Adjuvanted Recombinant Sporothrix spp. Enolase Antigen.",B,high_candidate,curator_rejected,reject,derived_annotations_only,CTLA-4 Antisense Oligonucleotide Contributes to Enhanced Immunogenicity of an Adjuvanted Recombinant Sporothrix spp. Enolase Antigen.
39154,68323,42149739,10.1080/15476286.2026.2675858,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Nusinersen: the antisense oligonucleotide at the forefront of spinal muscular atrophy treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Nusinersen: the antisense oligonucleotide at the forefront of spinal muscular atrophy treatment.
39155,68324,41898852,10.3390/genes17030318,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: From Genomic Diagnosis to Personalized RNA Medicine: Advances in Next-Generation Sequencing and N-of-1 Antisense Oligonucleotide Therapies for Rare Genetic Diseases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,From Genomic Diagnosis to Personalized RNA Medicine: Advances in Next-Generation Sequencing and N-of-1 Antisense Oligonucleotide Therapies for Rare Genetic Diseases.
39156,68325,41869866,10.1002/advs.202501909,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Inhaled Angiopoietin-Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Inhaled Angiopoietin-Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis.
39157,68326,41704705,10.3389/fmed.2026.1719202,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Investigation of the activity of phosphothioate and phosphothioate-LNA-modified oligonucleotides against HIV-1.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Investigation of the activity of phosphothioate and phosphothioate-LNA-modified oligonucleotides against HIV-1.
39158,68327,41583579,10.1093/narmme/ugag001,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Systemic distribution of tricyclo-DNA antisense oligonucleotide following intratracheal instillation in the mouse.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Systemic distribution of tricyclo-DNA antisense oligonucleotide following intratracheal instillation in the mouse.
39159,68328,41736386,10.1002/jssc.70372,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Enabling Large-Volume Injections in Hydrophilic Interaction Chromatography of Oligonucleotides Through In-Line Mixing.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enabling Large-Volume Injections in Hydrophilic Interaction Chromatography of Oligonucleotides Through In-Line Mixing.
39160,68329,41783787,10.1016/j.omtn.2026.102865,offtarget,siRNA,PMC full text high-precision preselection,sirna;galnac,"full-text off-target candidate; title/source terms=sirna, galnac; source title: GalNAc-conjugated siRNA targeting C/EBPβ reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model.",B,high_candidate,curator_rejected,reject,derived_annotations_only,GalNAc-conjugated siRNA targeting C/EBPβ reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model.
39161,68330,41683454,10.3390/molecules31030476,offtarget,siRNA,PMC full text high-precision preselection,sirna;galnac,"full-text off-target candidate; title/source terms=sirna, galnac; source title: Refined Design and Liquid-Phase Assembly of GalNAc-siRNA Conjugates: Comparative Efficiency Validation in PCSK9 Targeting.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Refined Design and Liquid-Phase Assembly of GalNAc-siRNA Conjugates: Comparative Efficiency Validation in PCSK9 Targeting.
39162,68331,41630988,10.1016/j.omtn.2026.102832,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Identification and functional validation of intracellular protein partners of phosphorothioate splice-switching oligonucleotides using AP-MS.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Identification and functional validation of intracellular protein partners of phosphorothioate splice-switching oligonucleotides using AP-MS.
39163,68332,42121345,10.1111/jcmm.71178,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: AP-1-Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,AP-1-Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways.
39164,68333,41754785,10.3390/ph19020244,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: 2025 FDA TIDES (Peptides and Oligonucleotides) Harvest.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,2025 FDA TIDES (Peptides and Oligonucleotides) Harvest.
39165,68334,41633500,10.1093/nar/gkag057,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Transient acute neuronal activation response caused by high concentrations of oligonucleotides in the cerebral spinal fluid.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Transient acute neuronal activation response caused by high concentrations of oligonucleotides in the cerebral spinal fluid.
39166,68335,41596367,10.3390/ijms27020717,offtarget,siRNA,PMC full text high-precision preselection,sirna;small interfering,"full-text off-target candidate; title/source terms=sirna, small interfering; source title: Small Interfering RNA (siRNA) as a Targeted Therapy for Acute Respiratory Distress Syndrome: Evidence from Experimental Models.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Small Interfering RNA (siRNA) as a Targeted Therapy for Acute Respiratory Distress Syndrome: Evidence from Experimental Models.
39167,68336,41512823,10.1016/j.molcel.2025.12.009,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains.
39168,68337,41380578,10.1016/j.chroma.2025.466600,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: The use of multiple liquid chromatography methods augmented by phosphorus-31 nuclear magnetic resonance to characterize the diastereomer composition in synthetic oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,The use of multiple liquid chromatography methods augmented by phosphorus-31 nuclear magnetic resonance to characterize the diastereomer composition in synthetic oligonucleotides.
39169,68338,41868107,10.1039/d6cb00038j,offtarget,siRNA,PMC full text high-precision preselection,sirna;rnai,"full-text off-target candidate; title/source terms=sirna, rnai; source title: Synthesis of siRNAs containing carbocyclic nucleotides and the role of cyclopentane conformation in RNAi activity.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synthesis of siRNAs containing carbocyclic nucleotides and the role of cyclopentane conformation in RNAi activity.
39170,68339,41852626,10.1021/acsptsci.5c00787,offtarget,siRNA,PMC full text high-precision preselection,sirna;small interfering,"full-text off-target candidate; title/source terms=sirna, small interfering; source title: Small Interfering Ribonucleic Acid (siRNA)-Based Therapeutics in Inflammatory Bowel Disease: Crosstalk between Immune Modulation and Epithelial Barrier Restoration.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Small Interfering Ribonucleic Acid (siRNA)-Based Therapeutics in Inflammatory Bowel Disease: Crosstalk between Immune Modulation and Epithelial Barrier Restoration.
39171,68340,41767047,10.3389/fmolb.2026.1767656,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: ATP-sensitive peptide-based coacervates for intracellular delivery of therapeutic oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,ATP-sensitive peptide-based coacervates for intracellular delivery of therapeutic oligonucleotides.
39172,68341,41725298,10.1111/pbi.70548,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Enhancing CRISPR/Cas-Mediated Gene Knockout With Short Non-Homologous Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Enhancing CRISPR/Cas-Mediated Gene Knockout With Short Non-Homologous Oligonucleotides.
39173,68342,41717657,10.1039/d5cb00302d,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Tuning potency for precision: the role of the G4-ligand in G4-ligand conjugated oligonucleotides targeting individual G-quadruplex DNA structures.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Tuning potency for precision: the role of the G4-ligand in G4-ligand conjugated oligonucleotides targeting individual G-quadruplex DNA structures.
39174,68343,41709035,10.1007/s12672-026-04583-3,offtarget,siRNA,PMC full text high-precision preselection,sirna;aso,"full-text off-target candidate; title/source terms=sirna, aso; source title: Ultrasound targeted microbubble delivery of JMJD2A siRNA induces ferroptosis remodels the tumor immune microenvironment and inhibits esophageal squamous cell carcinoma progression.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Ultrasound targeted microbubble delivery of JMJD2A siRNA induces ferroptosis remodels the tumor immune microenvironment and inhibits esophageal squamous cell carcinoma progression.
39175,68344,41596918,10.3390/foods15020318,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Yeast Efficiently Utilizes Ribosomal RNA-Derived Oligonucleotides as Bioavailable Nutrient Sources.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Yeast Efficiently Utilizes Ribosomal RNA-Derived Oligonucleotides as Bioavailable Nutrient Sources.
39176,68345,41529066,10.1371/journal.ppat.1013868,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: HIV-1 derived oligonucleotides induce a type I IFN/STING dependent immune suppression reversible by targeting IFNARI.",B,high_candidate,curator_rejected,reject,derived_annotations_only,HIV-1 derived oligonucleotides induce a type I IFN/STING dependent immune suppression reversible by targeting IFNARI.
39177,68346,41383013,10.1016/j.ymthe.2025.12.026,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: BLOC1S1 depletion via splice-switching oligonucleotides improves mitochondrial respiration and rescues ALS phenotypes.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,BLOC1S1 depletion via splice-switching oligonucleotides improves mitochondrial respiration and rescues ALS phenotypes.
39178,68347,41520082,10.1038/s42004-025-01882-8,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Versatile introduction of multifunctional Michael-acceptor moieties on amino-oligonucleotides for bioconjugation purposes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Versatile introduction of multifunctional Michael-acceptor moieties on amino-oligonucleotides for bioconjugation purposes.
39179,68348,40263630,10.1038/s41591-025-03656-0,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide treatment in a preterm infant with early-onset SCN2A developmental and epileptic encephalopathy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense oligonucleotide treatment in a preterm infant with early-onset SCN2A developmental and epileptic encephalopathy.
39180,68349,40098305,10.1111/cas.70024,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds.",B,high_candidate,curator_rejected,reject,derived_annotations_only,AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds.
39181,68350,41186228,10.1128/aac.00679-25,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Safety, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide RO7239958 in healthy volunteers and adults with chronic hepatitis B infection.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Safety, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide RO7239958 in healthy volunteers and adults with chronic hepatitis B infection."
39182,68351,41323696,10.1039/d5ra06597f,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Glycogen for Smyd3-antisense oligonucleotide delivery and enhanced liver cancer gene therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Glycogen for Smyd3-antisense oligonucleotide delivery and enhanced liver cancer gene therapy.
39183,68352,41280074,10.1101/2025.11.04.686541,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Preclinical evaluation of antisense oligonucleotide therapy in a mouse model of HNRNPH2-related neurodevelopmental disorder.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Preclinical evaluation of antisense oligonucleotide therapy in a mouse model of HNRNPH2-related neurodevelopmental disorder.
39184,68353,41166443,10.1093/nar/gkaf487,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Improved targeted delivery of antisense oligonucleotide with an antibody mask.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Improved targeted delivery of antisense oligonucleotide with an antibody mask.
39185,68354,41031595,10.1021/acschemneuro.5c00524,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Mass Spectrometry Imaging Reveals the Distribution of a GABRG2 Targeting Antisense Oligonucleotide and Its Functional Effect in Rat Brain.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Mass Spectrometry Imaging Reveals the Distribution of a GABRG2 Targeting Antisense Oligonucleotide and Its Functional Effect in Rat Brain.
39186,68355,41012491,10.3390/pharmaceutics17091154,offtarget,siRNA,PMC full text high-precision preselection,sirna;galnac,"full-text off-target candidate; title/source terms=sirna, galnac; source title: Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Whole-Body Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling for Interspecies Translation and Mechanistic Characterization of Plasma and Tissue Disposition of GalNAc-siRNAs.
39187,68356,40418024,10.1021/acs.analchem.5c01587,offtarget,siRNA,PMC full text high-precision preselection,sirna;galnac,"full-text off-target candidate; title/source terms=sirna, galnac; source title: Differential Protein Precipitation-Based GalNAc-siRNA Sample Preparation with LC/MS Method Development Workflow in Plasma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Differential Protein Precipitation-Based GalNAc-siRNA Sample Preparation with LC/MS Method Development Workflow in Plasma.
39188,68357,39974630,10.1021/acsptsci.4c00698,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: A Bioanalytical Liquid Chromatography Tandem Mass Spectrometry Approach for the Quantification of a Novel Antisense Oligonucleotide Designed for Parkinson's Disease: A Rat Brain Biodistribution Study.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A Bioanalytical Liquid Chromatography Tandem Mass Spectrometry Approach for the Quantification of a Novel Antisense Oligonucleotide Designed for Parkinson's Disease: A Rat Brain Biodistribution Study.
39189,68358,39861717,10.3390/pharmaceutics17010069,offtarget,siRNA,PMC full text high-precision preselection,sirna;galnac,"full-text off-target candidate; title/source terms=sirna, galnac; source title: Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs.
39190,68359,40101742,10.1093/jimmun/vkae055,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Cellular immune changes during severe antisense oligonucleotide-associated thrombocytopenia in a nonhuman primate model.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cellular immune changes during severe antisense oligonucleotide-associated thrombocytopenia in a nonhuman primate model.
39191,68360,41801895,10.1016/j.atherosclerosis.2025.120527,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide inhibition of HMGB1 attenuates angiotensin II-induced abdominal aortic aneurysms.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense oligonucleotide inhibition of HMGB1 attenuates angiotensin II-induced abdominal aortic aneurysms.
39192,68361,41423447,10.1038/s41467-025-67725-1,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Targeted antisense oligonucleotide treatment rescues developmental alterations in spinal muscular atrophy organoids.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Targeted antisense oligonucleotide treatment rescues developmental alterations in spinal muscular atrophy organoids.
39193,68362,41335008,10.18632/aging.206343,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: CD47 antisense oligonucleotide treatment improves glucose homeostasis and alleviates dyslipidemia in aged male mice.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,CD47 antisense oligonucleotide treatment improves glucose homeostasis and alleviates dyslipidemia in aged male mice.
39194,68363,41277693,10.1093/nar/gkaf1263,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages.
39195,68364,41210590,10.1016/j.omtn.2025.102729,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide-based switches for conditional translation of synthetic mRNA.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense oligonucleotide-based switches for conditional translation of synthetic mRNA.
39196,68365,40898620,10.1016/j.ymthe.2025.08.044,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide therapy mitigates autosomal dominant progressive hearing loss in a murine model of human DFNA2.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense oligonucleotide therapy mitigates autosomal dominant progressive hearing loss in a murine model of human DFNA2.
39197,68366,40865525,10.1016/j.cell.2025.07.045,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Molecular impact of antisense oligonucleotide therapy in C9orf72-associated ALS.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Molecular impact of antisense oligonucleotide therapy in C9orf72-associated ALS.
39198,68367,40763041,10.1002/psp4.70076,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: A Case Study of Model-Informed Drug Development of a Novel PCSK9 Antisense Oligonucleotide. Part 2: Phase 2 to Phase 3.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,A Case Study of Model-Informed Drug Development of a Novel PCSK9 Antisense Oligonucleotide. Part 2: Phase 2 to Phase 3.
39199,68368,40687881,10.1515/medgen-2025-2025,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide therapies for monogenic disorders.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense oligonucleotide therapies for monogenic disorders.
39200,68369,40501380,10.1161/ATVBAHA.124.321999,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense Oligonucleotide Targeting Sortilin Reduces Vascular Calcification in Mice in a Sex-Dependent Manner.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense Oligonucleotide Targeting Sortilin Reduces Vascular Calcification in Mice in a Sex-Dependent Manner.
39201,68370,40473796,10.1038/s43856-025-00932-5,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Suppression of NRAS-mutant melanoma growth with NRAS-targeting Antisense Oligonucleotide treatment reveals therapeutically relevant kinase co-dependencies.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Suppression of NRAS-mutant melanoma growth with NRAS-targeting Antisense Oligonucleotide treatment reveals therapeutically relevant kinase co-dependencies.
39202,68371,40414239,10.1016/S0140-6736(25)00513-6,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series."
39203,68372,40367190,10.1126/scitranslmed.adv4656,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Intra-amniotic antisense oligonucleotide treatment improves phenotypes in preclinical models of spinal muscular atrophy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Intra-amniotic antisense oligonucleotide treatment improves phenotypes in preclinical models of spinal muscular atrophy.
39204,68373,40237398,10.1002/prp2.70096,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: In Vitro Structure-Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Vitro Structure-Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases.
39205,68374,40235985,10.1101/2025.03.28.645811,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal-Organic Framework Nanoparticles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal-Organic Framework Nanoparticles.
39206,68375,39955311,10.1038/s41467-025-56913-8,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects.
39207,68376,39937271,10.1158/1078-0432.CCR-24-1818,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: AZD8701, an Antisense Oligonucleotide Targeting FOXP3 mRNA, as Monotherapy and in Combination with Durvalumab: A Phase I Trial in Patients with Advanced Solid Tumors.",B,high_candidate,curator_rejected,reject,derived_annotations_only,"AZD8701, an Antisense Oligonucleotide Targeting FOXP3 mRNA, as Monotherapy and in Combination with Durvalumab: A Phase I Trial in Patients with Advanced Solid Tumors."
39208,68377,41189054,10.1093/nar/gkaf1141,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten disease.
39209,68378,40501755,10.1101/2025.05.30.656864,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten disease.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten disease.
39210,68379,40206658,10.1016/j.omtn.2025.102503,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Correcting tau isoform ratios with a long-acting antisense oligonucleotide alleviates 4R-tauopathy phenotypes.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Correcting tau isoform ratios with a long-acting antisense oligonucleotide alleviates 4R-tauopathy phenotypes.
39211,68380,40091434,10.1002/adma.202419538,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Formulation and Characterization of Novel Ionizable and Cationic Lipid Nanoparticles for the Delivery of Splice-Switching Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Formulation and Characterization of Novel Ionizable and Cationic Lipid Nanoparticles for the Delivery of Splice-Switching Oligonucleotides.
39212,68381,39967852,10.1016/j.omtn.2024.102443,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells.
39213,68382,41599628,10.3390/ph19010026,offtarget,siRNA,PMC full text high-precision preselection,sirna;rnai,"full-text off-target candidate; title/source terms=sirna, rnai; source title: C16-siRNAs in Focus: Development of ALN-APP, a Promising RNAi-Based Therapeutic for Alzheimer's Disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"C16-siRNAs in Focus: Development of ALN-APP, a Promising RNAi-Based Therapeutic for Alzheimer's Disease."
39214,68383,41373892,10.3390/ijms262311747,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Biological Performance and Molecular Mechanisms of Mesyl MicroRNA-Targeted Oligonucleotides in Colorectal Cancer Cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Biological Performance and Molecular Mechanisms of Mesyl MicroRNA-Targeted Oligonucleotides in Colorectal Cancer Cells.
39215,68384,41044092,10.1038/s41467-025-64434-7,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Stereo-random oligonucleotides enable efficient recruitment of ADAR in vitro and in vivo.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Stereo-random oligonucleotides enable efficient recruitment of ADAR in vitro and in vivo.
39216,68385,40506605,10.1007/s10928-025-09980-9,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics.
39217,68386,40207629,10.1093/nar/gkaf270,offtarget,siRNA,PMC full text high-precision preselection,sirna;aso,"full-text off-target candidate; title/source terms=sirna, aso; source title: Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles.
39218,68387,40143070,10.3390/ph18030291,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: 2024 FDA TIDES (Peptides and Oligonucleotides) Harvest.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,2024 FDA TIDES (Peptides and Oligonucleotides) Harvest.
39219,68388,40045578,10.1016/j.ymthe.2025.02.045,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Clinical applications of oligonucleotides for cancer therapy.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Clinical applications of oligonucleotides for cancer therapy.
39220,68389,40034207,10.1016/j.omtn.2025.102468,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Effect of chemical modification on the exon-skipping activity of heteroduplex oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Effect of chemical modification on the exon-skipping activity of heteroduplex oligonucleotides.
39221,68390,39926316,10.1016/j.omtn.2024.102422,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform.
39222,68391,40800004,10.1016/j.omton.2025.201020,offtarget,siRNA,PMC full text high-precision preselection,sirna;shrna,"full-text off-target candidate; title/source terms=sirna, shrna; source title: Allele-specific depletion of GNAQ (Q209L) via siRNA or an rAAV2-shRNA vector induces selective toxicity in GNAQ (Q209L) uveal melanoma cells.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Allele-specific depletion of GNAQ (Q209L) via siRNA or an rAAV2-shRNA vector induces selective toxicity in GNAQ (Q209L) uveal melanoma cells.
39223,68392,40166479,10.3762/bjnano.16.34,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment.
39224,68393,39886752,10.1080/17576180.2025.2457894,offtarget,siRNA,PMC full text high-precision preselection,sirna;antisense,"full-text off-target candidate; title/source terms=sirna, antisense; source title: Simultaneous quantification of siRNA antisense and sense strands by hybrid liquid chromatography-mass spectrometry.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Simultaneous quantification of siRNA antisense and sense strands by hybrid liquid chromatography-mass spectrometry.
39225,68394,38633814,10.1101/2024.03.30.24305115,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide depletion of CCDC146 is a broad-spectrum therapeutic strategy for ALS.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Antisense oligonucleotide depletion of CCDC146 is a broad-spectrum therapeutic strategy for ALS.
39226,68395,41446468,10.7759/cureus.97562,offtarget,siRNA,PMC full text high-precision preselection,sirna;small interfering,"full-text off-target candidate; title/source terms=sirna, small interfering; source title: In Silico Development of a Targeted Small Interfering RNA (siRNA) Sequence to Silence Goblet Cell Mucin-5AC Overexpression in Cystic Fibrosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,In Silico Development of a Targeted Small Interfering RNA (siRNA) Sequence to Silence Goblet Cell Mucin-5AC Overexpression in Cystic Fibrosis.
39227,68396,41077722,10.1021/jacs.5c15110,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Cleavable Hydrophobic Anchors Optimize Immunomodulatory Effects of Oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Cleavable Hydrophobic Anchors Optimize Immunomodulatory Effects of Oligonucleotides.
39228,68397,41053953,10.1002/tcr.202500126,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Therapeutic Oligonucleotides for Neurodegenerative Diseases: Aptamer Strategies and Clay Nanoparticle-Based Delivery.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Therapeutic Oligonucleotides for Neurodegenerative Diseases: Aptamer Strategies and Clay Nanoparticle-Based Delivery.
39229,68398,40917895,10.1016/j.omtn.2025.102685,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Molecular properties and intramolecular interactions of peptide-conjugated phosphorodiamidate morpholino oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Molecular properties and intramolecular interactions of peptide-conjugated phosphorodiamidate morpholino oligonucleotides.
39230,68399,40877400,10.1038/s41598-025-16936-z,offtarget,siRNA,PMC full text high-precision preselection,sirna;rnai,"full-text off-target candidate; title/source terms=sirna, rnai; source title: Molecular dynamics simulations based siRNA design against GPR10 reveals stable RNAi therapeutics for hormone-dependent uterine fibroids.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Molecular dynamics simulations based siRNA design against GPR10 reveals stable RNAi therapeutics for hormone-dependent uterine fibroids.
39231,68400,40821543,10.1021/acsomega.5c02207,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Enhanced Accumulation of Heteroduplex Oligonucleotides in Dystrophin-Deficient Skeletal Muscles by Single Oligonucleotide-Loaded Unit Polyion Complexes.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Enhanced Accumulation of Heteroduplex Oligonucleotides in Dystrophin-Deficient Skeletal Muscles by Single Oligonucleotide-Loaded Unit Polyion Complexes.
39232,68401,40716251,10.1016/j.tranon.2025.102485,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Aptamer-mediated delivery of therapeutic oligonucleotides in glioblastoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Aptamer-mediated delivery of therapeutic oligonucleotides in glioblastoma.
39233,68402,40582054,10.1016/j.ultsonch.2025.107446,offtarget,siRNA,PMC full text high-precision preselection,sirna;aso,"full-text off-target candidate; title/source terms=sirna, aso; source title: A novel ultrasound-responsive cluster bomb system for efficient siRNA delivery in brain.",B,high_candidate,curator_rejected,reject,derived_annotations_only,A novel ultrasound-responsive cluster bomb system for efficient siRNA delivery in brain.
39234,68403,40363763,10.3390/molecules30091956,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Conditional Control of CRISPR/Cas9 Function by Chemically Modified Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Conditional Control of CRISPR/Cas9 Function by Chemically Modified Oligonucleotides.
39235,68404,40256168,10.1016/j.csbj.2025.03.034,offtarget,siRNA,PMC full text high-precision preselection,sirna;small interfering,"full-text off-target candidate; title/source terms=sirna, small interfering; source title: In Silico and In Vitro development of novel small interfering RNAs (siRNAs) to inhibit SARS-CoV-2.",B,high_candidate,curator_rejected,reject,derived_annotations_only,In Silico and In Vitro development of novel small interfering RNAs (siRNAs) to inhibit SARS-CoV-2.
39236,68405,40235852,10.1016/j.omtn.2025.102522,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro.
39237,68406,39970222,10.1126/sciadv.adr9266,offtarget,siRNA,PMC full text high-precision preselection,sirna;rnai,"full-text off-target candidate; title/source terms=sirna, rnai; source title: Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma.
39238,68407,39772535,10.1021/acs.jmedchem.4c02528,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Metabolic Stability and Targeted Delivery of Oligonucleotides: Advancing RNA Therapeutics Beyond The Liver.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Metabolic Stability and Targeted Delivery of Oligonucleotides: Advancing RNA Therapeutics Beyond The Liver.
39239,68408,39967271,10.1080/10717544.2025.2464921,offtarget,ASO,PMC full text high-precision preselection,aso;gapmer,"full-text off-target candidate; title/source terms=aso, gapmer; source title: ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound.",B,high_candidate,curator_rejected,reject,derived_annotations_only,ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound.
39240,68409,38742636,10.1093/nar/gkae350,offtarget,siRNA,PMC full text high-precision preselection,sirna;galnac,"full-text off-target candidate; title/source terms=sirna, galnac; source title: Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.
39241,68410,37980543,10.1016/j.ymthe.2023.11.012,offtarget,siRNA,PMC full text high-precision preselection,sirna;galnac,"full-text off-target candidate; title/source terms=sirna, galnac; source title: GalNAc-conjugated siRNA targeting the DNAJB1-PRKACA fusion junction in fibrolamellar hepatocellular carcinoma.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,GalNAc-conjugated siRNA targeting the DNAJB1-PRKACA fusion junction in fibrolamellar hepatocellular carcinoma.
39242,68411,39554992,10.1016/j.omtn.2024.102359,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca(2+) and Mg(2+) in the formulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca(2+) and Mg(2+) in the formulation.
39243,68412,38895198,10.1101/2024.06.06.597639,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca(2+) and Mg(2+) in the formulation.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca(2+) and Mg(2+) in the formulation.
39244,68413,40225946,10.1155/2024/9933129,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Treatability of the KMT2-Associated Neurodevelopmental Disorders Using Antisense Oligonucleotide-Based Treatments.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Treatability of the KMT2-Associated Neurodevelopmental Disorders Using Antisense Oligonucleotide-Based Treatments.
39245,68414,39595574,10.3390/biom14111397,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment.
39246,68415,39473221,10.1002/acn3.52234,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Rethinking antisense oligonucleotide therapeutics for amyotrophic lateral sclerosis.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Rethinking antisense oligonucleotide therapeutics for amyotrophic lateral sclerosis.
39247,68416,39457466,10.3390/genes15101342,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Recent Progress of Antisense Oligonucleotide Therapy for Superoxide-Dismutase-1-Mutated Amyotrophic Lateral Sclerosis: Focus on Tofersen.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Recent Progress of Antisense Oligonucleotide Therapy for Superoxide-Dismutase-1-Mutated Amyotrophic Lateral Sclerosis: Focus on Tofersen.
39248,68417,39416965,10.1021/acsptsci.4c00384,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Light-Promoted Lysosomal Escape of a Phthalocyanine and Antisense Oligonucleotide-Complexed G-Quadruplex for Dual Photodynamic and Antisense Therapy.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Light-Promoted Lysosomal Escape of a Phthalocyanine and Antisense Oligonucleotide-Complexed G-Quadruplex for Dual Photodynamic and Antisense Therapy.
39249,68418,39377066,10.1016/j.omtn.2024.102250,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Splice-switching antisense oligonucleotide controlling tumor suppressor REST is a novel therapeutic medicine for neuroendocrine cancer.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Splice-switching antisense oligonucleotide controlling tumor suppressor REST is a novel therapeutic medicine for neuroendocrine cancer.
39250,68419,38949758,10.1007/s40268-024-00467-5,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: A Randomized, Open-Label, Phase I, Single-Dose Study of Antisense Oligonucleotide, Vupanorsen, in Chinese Adults with Elevated Triglycerides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"A Randomized, Open-Label, Phase I, Single-Dose Study of Antisense Oligonucleotide, Vupanorsen, in Chinese Adults with Elevated Triglycerides."
39251,68420,39190037,10.1007/s00253-024-13283-3,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: Harnessing sulfur-binding domains to separate Sp and Rp isomers of phosphorothioate oligonucleotides.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Harnessing sulfur-binding domains to separate Sp and Rp isomers of phosphorothioate oligonucleotides.
39252,68421,39768315,10.3390/life14121607,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Evaluation of an Antisense Oligonucleotide Targeting CAG Repeats: A Patient-Customized Therapy Study for Huntington's Disease.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Evaluation of an Antisense Oligonucleotide Targeting CAG Repeats: A Patient-Customized Therapy Study for Huntington's Disease.
39253,68422,39292801,10.1126/scitranslmed.adk0845,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: A deep intronic splice-altering AIRE variant causes APECED syndrome through antisense oligonucleotide-targetable pseudoexon inclusion.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,A deep intronic splice-altering AIRE variant causes APECED syndrome through antisense oligonucleotide-targetable pseudoexon inclusion.
39254,68423,39286058,10.1183/23120541.00986-2023,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Randomised, phase 1/2a trial of ION-827359, an antisense oligonucleotide inhibitor of ENaC.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,"Randomised, phase 1/2a trial of ION-827359, an antisense oligonucleotide inhibitor of ENaC."
39255,68424,39277796,10.1093/hmg/ddae135,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels.
39256,68425,39155863,10.1161/CIRCULATIONAHA.123.068111,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense Oligonucleotide Therapy for Calmodulinopathy.",B,high_candidate,machine_precurated_v1,accept,derived_annotations_only,Antisense Oligonucleotide Therapy for Calmodulinopathy.
39257,68426,39122967,10.1038/s41591-024-03197-y,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Antisense oligonucleotide therapy in an individual with KIF1A-associated neurological disorder.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,Antisense oligonucleotide therapy in an individual with KIF1A-associated neurological disorder.
39258,68427,38379891,10.1177/26331055241233596,offtarget,ASO,PMC full text high-precision preselection,antisense;oligonucleotide,"full-text off-target candidate; title/source terms=antisense, oligonucleotide; source title: Synergistic Effect of an Antisense Oligonucleotide and Small Molecule on Splicing Correction of the Spinal Muscular Atrophy Gene.",B,high_candidate,curator_rejected,reject,derived_annotations_only,Synergistic Effect of an Antisense Oligonucleotide and Small Molecule on Splicing Correction of the Spinal Muscular Atrophy Gene.
39259,68428,39311689,10.1089/nat.2024.0036,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: An Evaluation of First-in-Human Studies for RNA Oligonucleotides.",B,high_candidate,curator_rejected,reject,derived_annotations_only,An Evaluation of First-in-Human Studies for RNA Oligonucleotides.
39260,68429,38804718,10.1021/acs.analchem.3c04351,offtarget,ASO/siRNA mixed context,PMC full text high-precision preselection,oligonucleotide;oligonucleotides,"full-text off-target candidate; title/source terms=oligonucleotide, oligonucleotides; source title: MIND4OLIGOS: Determining the Monoisotopic Mass of Oligonucleotides Observed in High-Resolution Mass Spectrometry.",B,high_candidate,candidate_needs_curator_review,pending,derived_annotations_only,MIND4OLIGOS: Determining the Monoisotopic Mass of Oligonucleotides Observed in High-Resolution Mass Spectrometry.