{
  "version": "20260604_core_validation_v45",
  "case_workflows": [
    {
      "id": "galnac_liver_safety",
      "title": "GalNAc-siRNA liver safety profile",
      "result_title": "Example result: GalNAc liver safety profile",
      "audience": "oligonucleotide drug discovery teams",
      "query": "galnac",
      "question": "Which verified safety records mention GalNAc delivery and hepatic/liver toxicity signals?",
      "primary_endpoint": "/api/modification_profile?term=galnac",
      "release_endpoint": "/api/evidence_records?domain=toxicity&q=galnac",
      "benchmark_endpoint": "/api/benchmark",
      "next_action": "Start from GalNAc profile counts, open toxicity evidence, then export A/B benchmark rows for model reuse.",
      "why_useful": "Connects delivery chemistry, liver safety evidence, provenance, and benchmark-eligible rows in one reusable path.",
      "workflow_steps": [
        "Open the GalNAc modification profile.",
        "Filter verified toxicity records by liver/hepatic endpoints.",
        "Download evidence_release.csv and benchmark_reference_splits.csv."
      ],
      "release_records": 22,
      "benchmark_task": "toxicity_safety_v0_1",
      "dashboard_cards": [
        {
          "label": "domain",
          "value": "toxicity"
        },
        {
          "label": "primary filter",
          "value": "GalNAc"
        },
        {
          "label": "evidence use",
          "value": "safety profile"
        }
      ]
    },
    {
      "id": "aso_gapmer_hepatotoxicity",
      "title": "ASO/gapmer hepatotoxicity review",
      "result_title": "Example result: ASO/gapmer hepatotoxicity review",
      "audience": "ASO chemistry and safety groups",
      "query": "hepatotoxicity",
      "question": "Which ASO/gapmer records have verified hepatotoxicity source locations and evidence grades?",
      "primary_endpoint": "/api/evidence_records?domain=toxicity&q=hepatotoxicity",
      "release_endpoint": "/api/evidence_records?domain=toxicity&q=hepatotoxicity",
      "benchmark_endpoint": "/api/benchmark",
      "next_action": "Compare Grade A/B/C hepatotoxicity evidence, inspect exact source locations, and cite record pages.",
      "why_useful": "Turns a broad safety concern into a citable, source-located evidence packet.",
      "workflow_steps": [
        "Search hepatotoxicity release records.",
        "Open record-level provenance and audit trail.",
        "Separate A/B benchmark records from C-grade contextual evidence."
      ],
      "release_records": 341,
      "benchmark_task": "toxicity_safety_v0_1",
      "dashboard_cards": [
        {
          "label": "domain",
          "value": "toxicity"
        },
        {
          "label": "primary filter",
          "value": "hepatotoxicity"
        },
        {
          "label": "evidence use",
          "value": "record citation"
        }
      ]
    },
    {
      "id": "renal_platelet_scan",
      "title": "Renal and thrombocytopenia safety scan",
      "result_title": "Example result: renal and platelet safety scan",
      "audience": "preclinical safety reviewers",
      "query": "renal",
      "question": "What verified and candidate safety evidence exists for renal or platelet-related endpoints?",
      "primary_endpoint": "/api/search?q=renal",
      "release_endpoint": "/api/evidence_records?domain=toxicity&q=renal",
      "benchmark_endpoint": "/api/benchmark",
      "next_action": "Use endpoint filters to build a renal or platelet-focused safety evidence packet.",
      "why_useful": "Shows how users can move between release evidence and candidate gaps before a review meeting.",
      "workflow_steps": [
        "Search renal or platelet endpoint terms.",
        "Inspect molecule/cohort and source-level evidence.",
        "Download filtered candidates for missing high-value records."
      ],
      "release_records": 51,
      "benchmark_task": "toxicity_safety_v0_1",
      "dashboard_cards": [
        {
          "label": "domain",
          "value": "toxicity"
        },
        {
          "label": "primary filter",
          "value": "renal"
        },
        {
          "label": "evidence use",
          "value": "gap scan"
        }
      ]
    },
    {
      "id": "sirna_seed_offtarget",
      "title": "siRNA seed/off-target transcriptome evidence",
      "result_title": "Example result: siRNA seed off-target evidence",
      "audience": "RNAi design and transcriptomics groups",
      "query": "seed",
      "question": "Which verified records support seed-mediated, mismatch, or transcriptome-level off-target evidence?",
      "primary_endpoint": "/api/evidence_records?domain=offtarget&q=seed",
      "release_endpoint": "/api/evidence_records?domain=offtarget&q=seed",
      "benchmark_endpoint": "/api/benchmark",
      "next_action": "Check observed off-target evidence, then use the sequence workbench for seed-window triage.",
      "why_useful": "Connects design triage with evidence records that computational RNAi users naturally reuse.",
      "workflow_steps": [
        "Filter off-target records by seed or mismatch evidence.",
        "Enter candidate guide sequence in the sequence workbench.",
        "Reuse offtarget_safety_v0_1 splits for baseline comparison."
      ],
      "release_records": 44,
      "benchmark_task": "offtarget_safety_v0_1",
      "dashboard_cards": [
        {
          "label": "domain",
          "value": "off-target"
        },
        {
          "label": "primary filter",
          "value": "seed"
        },
        {
          "label": "evidence use",
          "value": "design triage"
        }
      ]
    },
    {
      "id": "benchmark_reuse",
      "title": "Benchmark reuse with fixed reference splits",
      "result_title": "Example result: reproducible benchmark reuse",
      "audience": "ML and computational biology groups",
      "query": "toxicity_safety_v0_1",
      "question": "How should users cite and reuse fixed A/B-grade safety benchmark splits?",
      "primary_endpoint": "/api/benchmark",
      "release_endpoint": "/api/download/evidence_release.csv",
      "benchmark_endpoint": "/api/download/benchmark_reference_splits.csv",
      "next_action": "Download benchmark splits, task cards, and the release evidence; report the version and checksum.",
      "why_useful": "Makes the database citable by model developers without turning the paper into an algorithm paper.",
      "workflow_steps": [
        "Open benchmark metadata and task cards.",
        "Download fixed train/validation/test reference splits.",
        "Report task name, version, leakage policy, metrics, and checksum."
      ],
      "release_records": 737,
      "benchmark_task": "toxicity_safety_v0_1 / offtarget_safety_v0_1",
      "dashboard_cards": [
        {
          "label": "domain",
          "value": "benchmark"
        },
        {
          "label": "primary file",
          "value": "reference splits"
        },
        {
          "label": "evidence use",
          "value": "model reuse"
        }
      ]
    }
  ]
}